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studies regarding transcutaneous spinal cord stimulation indicate that non-invasive transcutaneous electrical stimulation of the spinal networks is very effective in restoring movement and function of the hands and arm for people with both complete paralysis and long-term spinal cord injury. This work lead directly to a multi-site clinical trial with ONWARD medical, for which Moritz serves as one of two co-PIs for the study. Parallel work is also exploring optogenetic stimulation of the spinal cord with collaborators
31:
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secondary appointments as assistant professor in the
Department of Physiology and Biophysics. He was promoted to Associate Professor in 2014, and later joined the Department of Electrical & Computer Engineering in 2018. Since 2010, he has been a member of the Graduate Faculty, and a mentor for the Neuroscience Graduate Program.
241:
Following his
Postdoctoral fellowship, Moritz joined the faculty at the University of Washington as a Research Assistant Professor in the Department of Physiology & Biophysics in 2009, and was promoted to Assistant Professor of Rehabilitation Medicine in 2010. Along with this appointment, he held
301:
Moritz and colleagues demonstrated that surface electromyography (sEMG) can be used to control a therapy video game using activation of weak or spastic muscles. Termed NeuroGame
Therapy (NGT), the team showed improve wrist control in children with cerebral palsy (CP) and tested the approach in older
363:
Inanici, F., Samejima, S., Gad, P., Edgerton, V. R., Hofstetter, C. P., & Moritz, C. T. (2018). Transcutaneous electrical spinal stimulation promotes long-term recovery of upper extremity function in chronic tetraplegia. IEEE Transactions on Neural
Systems and Rehabilitation Engineering, 26(6),
275:
Moritz's team demonstrated that stimulation of the spinal cord could lead to lasting improvements in hand and arm function that persisted beyond stimulation. This demonstration of ‘engineered neuroplasticity’ paved the way for human trials of spinal cord stimulation. He and Fatma
Inanici's recent
292:
In his studies of motor unit physiology, Moritz focused on experimentally measured force variability across a wide range of forces to improve the ability of a motor unit model to predict steadiness in the hand. He also published a paper in 2004 demonstrating the contributions of feed-forward
375:
Samejima, S., Khorasani, A., Ranganathan, V., Nakahara, J., Tolley, N. M., Boissenin, A., ... & Moritz, C. T. (2021). Brain-Computer-Spinal
Interface Restores Upper Limb Function After Spinal Cord Injury. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29,
293:
anticipation and neuro-mechanical reaction when humans encounter surprise, expected, and random changes from a soft elastic surface to a hard surface underfoot. Furthermore, he studied implications regarding muscle pre-stretch and elastic energy storage in locomotion.
258:
Moritz conducted a study in 2008 demonstrating that a brain-computer interface can be used to control stimulation of paralyzed muscles and restore movement. This has spawned several successful human trials of this concept in people with spinal cord injury. With
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Inanici, F., Brighton, L. N., Samejima, S., Hofstetter, C. P., & Moritz, C. T. (2021). Transcutaneous spinal cord stimulation restores hand and arm function after spinal cord injury. IEEE Transactions on Neural
Systems and Rehabilitation Engineering, 29,
149:, physiologist, and academic researcher. He is a Professor of Electrical and Computer Engineering, and holds joint appointments in the School of Medicine departments of Rehabilitation Medicine, and Physiology & Biophysics at the
349:
Moritz, C. T., Barry, B. K., Pascoe, M. A., & Enoka, R. M. (2005). Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscle. Journal of
Neurophysiology, 93(5),
367:
Bjånes, D. A., & Moritz, C. T. (2019). A robust encoding scheme for delivering artificial sensory information via direct brain stimulation. IEEE Transactions on Neural
Systems and Rehabilitation Engineering, 27(10),
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Kasten, M. R., Sunshine, M. D., & Moritz, C. T. (2012). Cervical intraspinal microstimulation improves forelimb motor recovery after spinal contusion injury. International
Functional Electrical Stimulation
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including stimulation to restore function after brain and spinal cord injury. His work also includes brain-computer interfaces to control muscle and spinal stimulation. His discoveries have been featured in
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Widge, A. S., & Moritz, C. T. (2014). Pre-frontal control of closed-loop limbic neurostimulation by rodents using a brain–computer interface. Journal of neural engineering, 11(2), 024001.
263:, Moritz also demonstrated that cognitive areas of the pre-frontal cortex could be used to limbic stimulation paving the way for psychiatric neuroprostheses and an allowed patent. With
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Lu, Chi; Park, Seongjun; Richner, Thomas J.; Derry, Alexander; Brown, Imogen; Hou, Chong; Rao, Siyuan; Kang, Jeewoo; Moritz, Chet T.; Fink, Yoel; Anikeeva, Polina (2017).
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Moritz, C. T., Perlmutter, S. I., & Fetz, E. E. (2008). Direct control of paralysed muscles by cortical neurons. Nature, 456(7222), 639–642.
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1194:"Preliminary Investigation of an Electromyography-Controlled Video Game as a Home Program for Persons in the Chronic Phase of Stroke Recovery"
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Moritz has worked in the area of neurotechnology, neuromodulation, brain-computer interfaces, and home rehabilitation physical therapy.
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Donoso Brown, Elena V.; McCoy, Sarah Westcott; Fechko, Amber S.; Price, Robert; Gilbertson, Torey; Moritz, Chet T. (2014).
1145:"Human hopping on very soft elastic surfaces: implications for muscle pre-stretch and elastic energy storage in locomotion"
318:
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Rios, D. C.; Gilbertson, T.; McCoy, S. W.; Price, R.; Gutman, K.; Miller, K. E. F.; Fechko, A.; Moritz, C. T. (2013).
1059:"Discharge Rate Variability Influences the Variation in Force Fluctuations Across the Working Range of a Hand Muscle"
818:"1. WO2015164477 - HYBRID SYSTEM FOR TREATING MENTAL AND EMOTIONAL DISORDERS WITH RESPONSIVE BRAIN STIMULATION"
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762:"Pre-frontal control of closed-loop limbic neurostimulation by rodents using a brain-computer interface"
1290:"Understanding upper extremity home programs and the use of gaming technology for persons after stroke"
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882:"Therapeutic intraspinal microstimulation improves forelimb function after cervical contusion injury"
833:"A Robust Encoding Scheme for Delivering Artificial Sensory Information via Direct Brain Stimulation"
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1002:"Flexible and stretchable nanowire-coated fibers for optoelectronic probing of spinal cord circuits"
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713:"Affective brain-computer interfaces as enabling technology for responsive psychiatric stimulation"
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in 2003. From 2003 till 2004, he served as a Postdoctoral Fellow of Integrative Physiology at the
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939:"Transcutaneous Spinal Cord Stimulation Restores Hand and Arm Function After Spinal Cord Injury"
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698:"Hybrid system for treating mental and emotional disorders with responsive brain stimulation"
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1243:"NeuroGame Therapy to improve wrist control in children with cerebral palsy: A case series"
528:"New treatment allows some people with spinal cord injury to regain hand and arm function"
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1353:"Therapeutic intraspinal stimulation to generate activity and promote long-term recovery"
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Cherng Jia and Elizabeth Yun Hwang Endowed Professorship of Spinal Cord Injury Research
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1098:"Passive dynamics change leg mechanics for an unexpected surface during human hopping"
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2020 - Weill Neurohub Investigator, Weill Neurohub at UCSF, Berkeley and U. Washington
1402:
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Donoso Brown, E. V.; Dudgeon, B. J.; Gutman, K.; Moritz, C. T.; McCoy, S. W. (2015).
972:
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Inanici, F.; Brighton, L. N.; Samejima, S.; Hofstetter, C. P.; Moritz, C. T. (2021).
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Kasten, M. R.; Sunshine, M. D.; Secrist, E. S.; Horner, P. J.; Moritz, C. T. (2013).
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267:, Moritz demonstrated a new way to provide sensory feedback directly to the brain.
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Moritz, Chet T.; Barry, Benjamin K.; Pascoe, Michael A.; Enoka, Roger M. (2005).
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and local TV news and community outreach videos. He has also been quoted in the
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2013 -2018 - Allen Distinguished Investigator, Paul G. Allen Family Foundation
108:
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233:, and subsequently rejoined the University of Washington as a Senior Fellow.
543:"Three people with spinal-cord injuries regain control of their leg muscles"
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Jackson, A.; Moritz, C. T.; Mavoori, J.; Lucas, T. H.; Fetz, E. E. (2006).
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652:"The neurochip BCI: towards a neural prosthesis for upper limb function"
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2012 - Young Faculty Award, Defense Advanced Research Projects Agency (
1161:
479:"University of Washington seeing success with nerve stimulation trial"
333:
2015 -2018 - International Research Consortium on Spinal Cord Injury,
1351:
Mondello, S. E.; Kasten, M. R.; Horner, P. J.; Moritz, C. T. (2014).
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943:
IEEE Transactions on Neural Systems and Rehabilitation Engineering
837:
IEEE Transactions on Neural Systems and Rehabilitation Engineering
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IEEE Transactions on Neural Systems and Rehabilitation Engineering
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75:
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Moritz, Chet T.; Perlmutter, Steve I.; Fetz, Eberhard E. (2008).
79:
Allen Distinguished Investigator, Paul G. Allen Family Foundation
508:"Once Paralyzed, Three Men Take Steps Again With Spinal Implant"
465:"Researchers develop a new treatment for spinal cord injuries"
447:"A New Way to Restore Hand Mobility—With an Electrified Patch"
217:
Moritz graduated with a bachelor's degree in Zoology from the
711:
Widge, Alik S.; Dougherty, Darin D.; Moritz, Chet T. (2014).
595:"Direct control of paralysed muscles by cortical neurons"
81:
International Research Consortium on Spinal Cord Injury,
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76:Defense Advanced Research Projects Agency (DARPA)
1198:Archives of Physical Medicine and Rehabilitation
426:"Device revives paralyzed muscles in monkeys"
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1143:Moritz, Chet T.; Farley, Claire T. (2005).
1096:Moritz, Chet T.; Farley, Claire T. (2004).
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83:Christopher & Dana Reeve Foundation
53:, physiologist, academic and researcher
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288:Motor unit physiology and biomechanics
831:Bjanes, D. A.; Moritz, C. T. (2019).
392:
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335:Christopher and Dana Reeve Foundation
7:
760:Widge, A. S.; Moritz, C. T. (2014).
225:, and earned his Doctoral Degree in
1424:Electrical and computer engineering
506:Carey, Benedict (31 October 2018).
223:University of California, Berkeley
118:University of California, Berkeley
14:
1247:Developmental Neurorehabilitation
221:in 1998. He then enrolled at the
1434:University of Washington faculty
313:American Society of Biomechanics
156:Moritz's research is focused on
145:is an American neural engineer,
1149:Journal of Experimental Biology
1114:10.1152/japplphysiol.00393.2004
72:, National Institutes of Health
1:
1294:Disability and Health Journal
1102:Journal of Applied Physiology
906:10.1088/1741-2560/10/4/044001
886:Journal of Neural Engineering
786:10.1088/1741-2560/11/2/024001
766:Journal of Neural Engineering
319:National Institutes of Health
1259:10.3109/17518423.2013.766818
729:10.1080/2326263X.2014.912885
1450:
1306:10.1016/j.dhjo.2015.03.007
1210:10.1016/j.apmr.2014.02.025
1063:Journal of Neurophysiology
956:10.1109/TNSRE.2021.3049133
850:10.1109/TNSRE.2019.2936739
555:10.1038/d41586-018-07251-x
493:"Dr. Chet Moritz W2W 2017"
311:2003 - President's Award,
103:Ph.D., Integrative Biology
1357:Frontiers in Neuroscience
717:Brain-Computer Interfaces
668:10.1109/TNSRE.2006.875547
302:adults following stroke.
254:Brain computer interfaces
205:, and in a news story by
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1414:American neuroscientists
1370:10.3389/fnins.2014.00021
541:Warren, Matthew (2018).
219:University of Washington
151:University of Washington
132:University of Washington
114:University of Washington
16:American neural engineer
167:, MSNBC national news,
1026:10.1126/sciadv.1600955
231:University of Colorado
1075:10.1152/jn.01122.2004
317:2009 - EUREKA Award,
74:Young Faculty Award,
1338:"President's Awards"
1018:2017SciA....3E0955L
898:2013JNEng..10d4001K
778:2014JNEng..11b4001W
619:10.1038/nature07418
611:2008Natur.456..639M
481:. 14 November 2018.
297:Home rehabilitation
227:Integrative Biology
192:Scientific American
93:Academic background
1409:Neural engineering
577:"Chet Moritz, PhD"
513:The New York Times
495:. 17 January 2018.
467:. 13 January 2021.
434:. 15 October 2008.
1162:10.1242/jeb.01472
843:(10): 1994–2004.
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306:Awards and honors
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129:Institutions
70:EUREKA Award
949:: 310–319.
38:Nationality
1403:Categories
987:"DISCOVER"
381:References
376:1233–1242.
368:1994–2004.
364:1272–1278.
350:2449–2459.
261:Alik Widge
109:Alma mater
973:230784607
867:201631170
213:Education
98:Education
1389:24578680
1324:25953349
1275:17152199
1267:23617243
1228:24657112
1179:18423169
1171:15755892
1122:15169748
1083:15615827
1044:28435858
965:33400652
924:23715242
859:31443035
804:24608127
747:25580443
684:16332802
676:16792290
637:18923392
563:80955607
431:NBC News
372:310–319.
357:Society.
246:Research
186:Newsweek
41:American
1380:3936503
1315:4570873
1219:4337946
1130:6551948
1035:5371423
1014:Bibcode
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1263:PMID
1224:PMID
1167:PMID
1118:PMID
1079:PMID
1040:PMID
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920:PMID
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