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and oversaw a USD 1 million research budget that gave grants to hundreds of scientists. In 1959, he refuted his earlier assertion, made as
Director of the ACS, that inhaling fine particles is unhealthy, and stated that smoking does not cause lung cancer and is at most a minor contributing factor. A
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in 1938. Little energetically developed both the lab and the ACS, and by 1944 they were shipping 9000 mice a week to other laboratories. The laboratory and all of the livestock were destroyed in the Great Bar Harbor Fire in the Fall of 1947. The lab was quickly rebuilt and most mouse strains were
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to change the building's name because of Little's previous support of eugenics. The C. C. Little
Science Building sign was replaced without Little's name on March 29, 2018. On April 26, 2021, the University of Maine announced that C. C. Little Hall would be renamed after
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decade later he stated, "there is no demonstrated causal relationship between smoking or any disease." In keeping with his earlier research, he believed that the main cause of cancer was genetic, not environmental.
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362:. He left Michigan in 1929 in order to devote himself to his research at Bar Harbor. With funding from Detroit car manufacturers, he was able to improve the facility for year-round use. He renamed it the "
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explanation for the inheritance of a trait that has apparently non-Mendelian characteristics". His observations on transplant rejection became codified into the "five laws of transplant immunology" by
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307:, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. In 1921, he inbred the mouse strain
450:. In 2022 the name change was complete. The building is now formally called Beryl Warner Williams Hall, and has a new cultural exhibit in the lobby.
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Corporation. Also in 1929, he took on a part-time job as managing director of the
American Society for the Control of Cancer (later became the
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by Hugh
Auchincloss Jr* and Henry J. Winn, "American Journal of Transplantation", Volume 4 Issue 2 Page 155 - February 2004
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in 1922, becoming at age 33 the youngest university president in the country. While there he started a summer laboratory in
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recovered from other labs around the world. By 1950, the lab was maintaining 60 inbred strains, and had developed the F
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in 1910, an M.S. in 1912, and D.Sc. in 1914 in zoology, with special focus in the new science of genetics. During
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His last major post, from 1954 to 1969, was as the
Scientific Director of the Scientific Advisory Board of the
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to date. His most important research occurred at
Harvard, including what some call his most brilliant work, "A
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of mice while at
Harvard. For his research, he received posthumously the 1978 Cancer Research Institute
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495:"Abbie Lathrop, the "Mouse Woman of Granby": Rodent Fancier and Accidental Genetics Pioneer"
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hybrid that became widely used for chemical testing. Little resigned in 1954.
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Clarence Cook Little (1888-1971): The
Genetic Basis of Transplant Immunology
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Steensma, David P.; Kyle, Robert A.; Shampo, Marc A. (November 2010).
577:"Newsletter of the Beer, .W, ne, Main Office: 115 W. Sunrise Highway"
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555:
480:"Why the C.C. Little Building Should be Renamed – Learn Speak Act"
304:
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in 1964). In that role, he was a leading scientific voice of the
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596:"Group Submits Request to Rename C. C. Little Building"
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Italics denote acting or interim president (or term)
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32:
366:" in honor of one donor, Roscoe B. Jackson of the
346:. In 1925, he left to become the President of the
693:National Academy of Sciences Biographical Memoir
663:Tobacco-related documents that mention Little.
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338:Little accepted the post of President of the
220:(October 6, 1888 – December 22, 1971) was an
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548:"Astuces pour en finir avec le tabac !"
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433:The C. C. Little Science Building at the
1217:Presidents of the University of Michigan
800:Presidents of the University of Michigan
311:or "black 6", which is the most popular
1257:Academics from Brookline, Massachusetts
750:President of the University of Michigan
620:Flaherty, Colleen (September 7, 2017).
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55:President of the University of Michigan
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374:(ACS)) and served as President to the
1267:Presidents of the University of Maine
1045:Presidents of the University of Maine
259:after his secondary education at the
7:
651:", Vol. 161, 1357–1361, August 2002.
645:C. C. Little, Cancer and Inbred Mice
683:"The strange career of C.C. Little"
403:Tobacco Industry Research Committee
594:Basha, Riyah (September 2, 2017).
207:academic administrator, researcher
25:
1277:Noble and Greenough School alumni
840:(1869–1871, 1880–1882, 1887–1888)
385:was extremely limited during the
1232:American birth control activists
1287:20th-century American academics
579:. 20 March 2007. Archived from
437:, and C. C. Little Hall at the
279:. In 1921, he helped found the
263:. Little received an A.B. from
622:"Honors for Racist Scientists"
1:
460:Eugenics in the United States
323:. Little developed the "DBA (
303:, Little began his work with
281:American Birth Control League
277:Cold Spring Harbor Laboratory
1272:Smoking in the United States
1262:Tobacco in the United States
407:Council for Tobacco Research
325:Dilute, Brown and non-Agouti
239:, as well as a proponent of
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678:, 32, 1354-1356, June 1972
261:Noble and Greenough School
129:Board of Trustees (acting)
1252:Harvard University alumni
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807:
756:
746:
733:
727:Harold Sherburne Boardman
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713:
705:
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391:National Cancer Institute
376:American Eugenics Society
251:C. C. Little was born in
211:
145:
112:
60:
48:
39:
1247:American segregationists
939:James Johnson Duderstadt
661:Tobacco Documents Online
552:www.tobaccodocuments.org
253:Brookline, Massachusetts
168:Brookline, Massachusetts
893:Alexander Grant Ruthven
760:Alexander Grant Ruthven
499:Mayo Clinic Proceedings
372:American Cancer Society
271:, Little served in the
95:Alexander Grant Ruthven
435:University of Michigan
348:University of Michigan
333:William B. Coley Award
273:U.S. Army Signal Corps
237:academic administrator
931:Harold Tafler Shapiro
909:Robben Wright Fleming
685:Christopher Zbrozek,
512:10.4065/mcp.2010.0647
299:While studying under
1242:American geneticists
1237:American eugenicists
1162:Hutchinson (1992–97)
859:1897–1898, 1909–1910
855:Harry Burns Hutchins
847:James Burrill Angell
838:Henry Simmons Frieze
482:. 22 September 2017.
218:Clarence Cook Little
34:Clarence Cook Little
18:Clarence Cook Little
1282:Tobacco researchers
1144:Silverman (1973–79)
867:Marion LeRoy Burton
821:Henry Philip Tappan
742:Marion LeRoy Burton
717:University of Maine
647:by James F. Crow, "
439:University of Maine
340:University of Maine
107:University of Maine
83:Marion LeRoy Burton
27:American geneticist
876:Alfred Henry Lloyd
829:Erastus Otis Haven
737:Alfred Henry Lloyd
709:Robert Judson Aley
689:September 26, 2006
687:The Michigan Daily
600:The Michigan Daily
430:at the age of 83.
383:Jackson Laboratory
364:Jackson Laboratory
265:Harvard University
257:Harvard University
198:Harvard University
141:Harold S. Boardman
78:Alfred Henry Lloyd
1204:
1203:
1172:Kennedy (2005–11)
1149:Johnson (1984–86)
1081:Fellows (1902–10)
1010:
1009:
766:
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757:Succeeded by
724:Succeeded by
715:President of the
701:Academic offices
583:on 20 March 2007.
422:Little died of a
215:
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178:December 22, 1971
16:(Redirected from
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1167:Hoff (1997–2004)
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428:Ellsworth, Maine
418:Death and legacy
411:tobacco industry
387:Great Depression
381:Funding for the
368:Hudson Motor Car
313:laboratory mouse
289:Lothrop Stoddard
185:Ellsworth, Maine
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150:Personal details
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977:(2002–2014,
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911:(1968–1979,
885:C. C. Little
884:
874:
861:, 1910–1920)
858:
836:
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631:September 7,
629:. Retrieved
625:
615:
603:. Retrieved
599:
589:
581:the original
571:
560:. Retrieved
556:the original
551:
502:
498:
488:
474:
432:
424:heart attack
421:
400:
380:
337:
321:George Snell
301:W. E. Castle
298:
250:
217:
216:
180:(1971-12-22)
137:Succeeded by
114:
90:Succeeded by
62:
1227:1971 deaths
1222:1888 births
1076:(1893–1901)
989:(2014–2022)
959:(1996–2002)
941:(1988–1996)
933:(1980–1988)
903:(1951–1968)
895:(1929–1951)
887:(1925–1929)
869:(1920–1925)
849:(1871–1909)
831:(1863–1869)
823:(1852–1863)
815:(1817–1821)
605:December 8,
505:(11): e83.
426:in 1971 in
269:World War I
125:Preceded by
73:Preceded by
1211:Categories
1188:(2014–18 )
674:Obituary,
562:2019-03-21
466:References
360:euthanasia
344:Bar Harbor
247:Early life
204:Profession
193:Alma mater
161:1888-10-06
1180:(2011–14)
1157:(1986–91)
1129:(1965–68)
1121:(1958–65)
1113:(1934–58)
1105:(1925–34)
1097:(1922–25)
1089:(1911–21)
1068:(1879–93)
1060:(1871–78)
995:Santa Ono
739:(interim)
405:(renamed
317:Mendelian
119:1922–1925
115:In office
103:President
67:1925–1929
63:In office
1178:Ferguson
1103:Boardman
997:(2022– )
649:Genetics
531:21061734
454:See also
352:eugenics
241:eugenics
225:genetics
222:American
80:(acting)
1119:Elliott
1066:Fernald
522:2966381
309:C57BL/6
233:tobacco
105:of the
1186:Hunter
1095:Little
1074:Harris
968:(2002)
950:(1996)
924:(1979)
878:(1925)
529:
519:
358:, and
329:strain
295:Career
231:, and
229:cancer
187:, U.S.
170:, U.S.
1127:Young
1111:Hauck
1058:Allen
283:with
1155:Lick
1087:Aley
979:2022
913:1988
748:6th
633:2017
607:2017
527:PMID
305:mice
287:and
175:Died
155:Born
101:6th
53:6th
517:PMC
507:doi
327:)"
1213::
624:.
598:.
550:.
539:^
525:.
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503:85
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497:.
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857:(
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609:.
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509::
396:1
163:)
159:(
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
