641:
618:
987:
51:
42:
5657:
1117:. In these people, the drug reaches threefold higher plasma concentrations at seven hours after intake, and it has a half-life of 89 hours (compared to a 27-hour half-life in normal metabolizers). Adverse effects were reported at similar rates in poor metabolizers, suggesting that it is not clinically relevant.
1683:
Kazmi F, Barbara JE, Yerino P, Parkinson A (April 2015). "A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement".
1724:"Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor"
1429:
Lee HE, Chang IK, Lee Y, Kim CD, Seo YJ, Lee JH, et al. (December 2014). "Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study".
228:
1647:
2488:
183:
1562:
979:; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide. Both desloratadine and 3-hydroxydesloratadine are eliminated via urine and feces with a
81:
1197:
loratadine is metabolized to descarboethoxyloratadine predominantly by cytochrome P450 3A4 (CYP3A4) and, to a lesser extent, by cytochrome P450 2D6 (CYP2D6).
721:
5707:
2481:
1600:"Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: a review of the evidence"
5712:
971:
Desloratadine is metabolized to 3-hydroxydesloratadine in a three-step sequence in normal metabolizers. First, N-glucuronidation of desloratadine by
4007:
1851:
1658:
845:
and the two drugs are similar in safety and effectiveness. Desloratadine is available in many dosage forms and under many brand names worldwide.
4012:
2474:
1573:
5697:
5630:
5616:
5596:
5273:
4045:
3501:
2541:
809:
It was patented in 1984 and came into medical use in 2001. It was brought to the market in the US by
Schering Corporation, later named
707:
5296:
2081:
5677:
2091:
1340:
1313:
949:
741:
5687:
1242:
1216:
5692:
1134:
Murdoch D, Goa KL, Keam SJ (7 April 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders".
391:
213:
113:
749:
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
1362:
132:
4002:
1844:
830:
517:
5579:
597:
5647:
3282:
1987:
5266:
1654:
1569:
1273:
4550:
4145:
4038:
3312:
2783:
2277:
2005:
1958:
999:
466:
1786:"Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice"
5623:
5306:
5036:
2573:
1837:
1512:
González-Núñez V, Valero A, Mullol J (May 2013). "Safety evaluation of desloratadine in allergic rhinitis".
169:
4257:
1178:
636:
5362:
4125:
3203:
1007:
302:
5682:
5519:
5413:
5367:
4252:
4120:
3918:
3895:
3712:
3694:
3463:
3366:
2508:
457:
240:
586:
4090:
5702:
5259:
4848:
4492:
4397:
980:
348:
5105:
4788:
964:
concentrations after about three hours. In the bloodstream, 83 to 87% of the substance are bound to
5341:
4873:
4813:
4743:
4387:
4085:
4031:
3168:
2713:
2526:
2209:
2087:
986:
945:
613:
412:
176:
50:
5326:
5225:
5061:
4993:
4858:
3640:
3635:
3575:
3535:
3444:
3424:
3143:
3063:
3043:
5544:
5468:
5240:
5170:
5155:
5145:
4978:
4738:
4733:
3670:
3605:
3550:
3434:
3178:
3118:
3098:
3088:
3003:
2973:
2778:
2708:
2698:
2500:
2497:
2200:
2077:
1537:
1454:
1159:
143:
5195:
5150:
5140:
4973:
4868:
4703:
4457:
4287:
3967:
3846:
3665:
3630:
3565:
3555:
3439:
3429:
3419:
3414:
3188:
3138:
2998:
2983:
2978:
2958:
5235:
5115:
4938:
4833:
4808:
4748:
3826:
3675:
3660:
3620:
3585:
3449:
3193:
3153:
3133:
3123:
3033:
566:
5603:
5311:
4177:
4095:
3913:
3796:
3409:
3264:
1815:
1745:
1701:
1629:
1529:
1489:
1446:
1374:
1336:
1330:
1309:
1151:
865:
822:
799:
265:
252:
63:
3791:
3786:
1472:
Layton AM (April 2016). "Top Ten List of
Clinical Pearls in the Treatment of Acne Vulgaris".
5357:
5316:
4953:
4918:
3390:
3257:
2873:
2733:
2653:
2420:
2122:
1964:
1944:
1805:
1797:
1735:
1693:
1619:
1611:
1521:
1481:
1438:
1301:
1143:
1114:
826:
653:
506:
421:
361:
284:
526:
5661:
5504:
5393:
5372:
5135:
5071:
5031:
4988:
4983:
4793:
4693:
4555:
4105:
2793:
2753:
2728:
2613:
2435:
2147:
2067:
1954:
1923:
1268:
1014:
930:
908:
3-hydroxydesloratadine in studies. However, no clinically relevant changes were observed.
810:
338:
312:
292:
1404:
1243:"Clarinex-D 12 HOUR- desloratadine and pseudoephedrine sulfate tablet, extended release"
640:
617:
5559:
5301:
5282:
5160:
5013:
5003:
4903:
4688:
4648:
4515:
4312:
4232:
4140:
4100:
4062:
3841:
3370:
3260:
3083:
3023:
2938:
2773:
2718:
2688:
2648:
2638:
2633:
2415:
2380:
2312:
2229:
2214:
2190:
2165:
2160:
2072:
2027:
2020:
1624:
1599:
1305:
1110:
965:
5671:
5423:
5336:
5056:
5051:
5046:
5021:
4958:
4943:
4640:
4447:
4412:
4392:
4237:
4172:
4115:
4080:
3356:
3352:
3316:
3276:
3219:
3215:
3078:
2918:
2903:
2828:
2823:
2628:
2390:
2262:
2218:
2180:
2175:
2127:
1939:
1873:
1860:
1810:
1785:
1770:
1163:
1147:
926:
787:
629:
105:
91:
1541:
5549:
5448:
5331:
5321:
5120:
4963:
4928:
4888:
4863:
4818:
4783:
4773:
4708:
4683:
4673:
4630:
4620:
4615:
4605:
4590:
4570:
4560:
4482:
4477:
4452:
4422:
4317:
4302:
4227:
4222:
4207:
4202:
4130:
4110:
3972:
3876:
3816:
3737:
3610:
3394:
3386:
3378:
3374:
3360:
3324:
3320:
3306:
3235:
3207:
3073:
3058:
2943:
2933:
2928:
2923:
2898:
2893:
2863:
2843:
2833:
2798:
2748:
2678:
2598:
2455:
2445:
2355:
2335:
2324:
2302:
2292:
2282:
2137:
2042:
1992:
1979:
1864:
1458:
961:
893:
889:
885:
853:
446:
196:
191:
1296:
Lieberman P, Hernandez-Trujillo V, Lieberman J, Frew AJ (2008). "Antihistamines".
1615:
1525:
1013:
Desloratadine does not have a strong effect on a number of tested enzymes in the
5609:
5524:
5478:
5473:
5458:
5453:
5443:
5418:
5230:
5200:
5185:
5084:
5079:
5026:
4968:
4908:
4893:
4878:
4838:
4778:
4768:
4758:
4718:
4678:
4653:
4610:
4600:
4595:
4585:
4580:
4545:
4540:
4510:
4442:
4437:
4417:
4382:
4372:
4357:
4352:
4337:
4327:
4282:
4267:
4247:
4212:
3957:
3928:
3861:
3856:
3851:
3836:
3801:
3742:
3717:
3680:
3590:
3511:
3506:
3398:
3348:
3328:
3302:
3294:
3247:
3243:
3227:
3183:
3148:
3128:
3108:
3103:
2988:
2953:
2913:
2878:
2868:
2853:
2818:
2808:
2788:
2768:
2763:
2758:
2723:
2673:
2668:
2658:
2603:
2578:
2546:
2531:
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2430:
2360:
2345:
2340:
2320:
2297:
2287:
2272:
2267:
2185:
2132:
2117:
2107:
2097:
2047:
2032:
1997:
1908:
1507:
1505:
1503:
99:
1049:. Desloratadine was found to be a potent and relatively selective inhibitor of
5539:
5534:
5529:
5488:
5483:
5438:
5398:
5377:
5220:
5210:
5125:
4948:
4933:
4913:
4853:
4828:
4803:
4763:
4753:
4723:
4698:
4668:
4625:
4575:
4535:
4525:
4520:
4472:
4467:
4432:
4407:
4402:
4367:
4307:
4292:
4262:
4197:
4192:
4187:
4167:
4075:
3977:
3866:
3831:
3811:
3806:
3750:
3655:
3650:
3645:
3625:
3615:
3595:
3580:
3570:
3560:
3545:
3540:
3340:
3268:
3239:
3231:
3158:
3093:
3053:
3048:
3013:
3008:
2968:
2963:
2888:
2813:
2738:
2703:
2693:
2663:
2643:
2623:
2583:
2450:
2425:
2330:
2254:
2249:
2234:
2170:
2155:
2015:
1969:
1949:
1903:
1893:
1888:
1801:
1485:
1382:
1003:
991:
905:
901:
897:
842:
838:
803:
683:
497:
328:
33:
5514:
5463:
5428:
5408:
5403:
5251:
5215:
5180:
5175:
5165:
5130:
5110:
5100:
5041:
4923:
4898:
4823:
4728:
4713:
4663:
4658:
4565:
4505:
4500:
4462:
4427:
4342:
4322:
4297:
4272:
4242:
4217:
4182:
4162:
4157:
4054:
3962:
3923:
3871:
3821:
3722:
3600:
3496:
3481:
3344:
3332:
3298:
3286:
3272:
3223:
3211:
3173:
3163:
3113:
3068:
3018:
2993:
2908:
2883:
2858:
2848:
2838:
2803:
2743:
2683:
2618:
2608:
2588:
2536:
2384:
2350:
2244:
2224:
2057:
2052:
2037:
2010:
1934:
1913:
1898:
1765:
869:
784:
371:
85:
1819:
1749:
1740:
1723:
1705:
1697:
1633:
1533:
1493:
1450:
1378:
1155:
41:
952:. This effect is not relevant for the drug's action at therapeutic doses.
904:
resulted in elevated blood plasma concentrations of desloratadine and its
5554:
5433:
5205:
4998:
4883:
4798:
4377:
4362:
4347:
4332:
4070:
3982:
3941:
3881:
3776:
3771:
3755:
3491:
3486:
3382:
3290:
3251:
3038:
2593:
2410:
2112:
1974:
998:
It exhibits only peripheral activity since it does not readily cross the
873:
477:
127:
486:
17:
4843:
4277:
3781:
3732:
3519:
3336:
2554:
2440:
2401:
2316:
1829:
1090:
1058:
1054:
1050:
1046:
972:
795:
432:
317:
1442:
1179:"CLARITIN brand of Loratadine - Full Prescribing Information (US FDA)"
3936:
3727:
1098:
1094:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
976:
577:
321:
546:
985:
834:
706:
697:
557:
5190:
960:
Desloratadine is well absorbed from the gut and reaches highest
934:
849:
848:
An emerging indication for desloratadine is in the treatment of
537:
271:
246:
5255:
4027:
2470:
1833:
259:
122:
1431:
Journal of the
European Academy of Dermatology and Venereology
4023:
1722:
Kazmi F, Yerino P, Barbara JE, Parkinson A (September 2015).
602:
1717:
1715:
222:
154:
975:; then, 3-hydroxylation of desloratadine N-glucuronide by
1113:
and 18% of people from
African descent are desloratadine
235:
766:
5645:
1211:
1209:
1207:
1205:
856:
and possibly as maintenance therapy or monotherapy.
5588:
5572:
5497:
5386:
5350:
5289:
5093:
5070:
5012:
4639:
4491:
4139:
4061:
3950:
3906:
3894:
3764:
3705:
3693:
3528:
3474:
3462:
2563:
2519:
2507:
2399:
2369:
2199:
2146:
1922:
1872:
1784:Mann RD, Pearce GL, Dunn N, Shakir S (April 2000).
695:
682:
652:
647:
628:
596:
576:
556:
536:
516:
496:
476:
465:
456:
431:
411:
382:
370:
360:
347:
337:
327:
311:
301:
291:
283:
212:
207:
182:
168:
142:
112:
98:
80:
72:
62:
57:
1291:
1289:
1287:
1285:
445:
420:
399:8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5
5267:
4039:
2482:
1845:
1217:"Clarinex- desloratadine tablet, film coated"
8:
1761:
1759:
131:
32:
5494:
5274:
5260:
5252:
4046:
4032:
4024:
3903:
3702:
3471:
2516:
2489:
2475:
2467:
1852:
1838:
1830:
639:
616:
505:
1809:
1739:
1623:
1356:
1354:
1352:
525:
376:40% as conjugated metabolites into urine
356:27 hours, 33.7 hours in elderly patients
5652:
1598:Canonica GW, Blaiss M (February 2011).
1557:
1555:
1553:
1551:
1126:
1017:system. It was found to weakly inhibit
746:
726:
612:
485:
396:
104:
1648:"Aerius: EPAR – Scientific Discussion"
1604:The World Allergy Organization Journal
1335:. John Wiley & Sons. p. 549.
1006:because it does not readily enter the
729:Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4
630:
31:
5597:Merck Manual of Diagnosis and Therapy
1878:
1769:
1363:"Desloratadine for allergic rhinitis"
585:
565:
90:
7:
1563:"Aerius: EPAR – Product Information"
1002:; hence, it does not normally cause
983:of 27 hours in normal metabolizers.
195:
990:3-Hydroxydesloratadine is the main
545:
436:
5713:Drugs developed by Merck & Co.
5708:Drugs developed by Schering-Plough
2754:Etybenzatropine (ethylbenztropine)
1520:(3). Informa Healthcare: 445–453.
1306:10.1016/b978-0-323-04404-2.10089-2
1053:, a weak to moderate inhibitor of
950:muscarinic acetylcholine receptors
25:
4794:Levomepromazine/Methotrimeprazine
864:The most common side-effects are
5655:
4413:Nortriptyline (noramitriptyline)
1935:Bromazine (bromodiphenhydramine)
1300:. Elsevier. pp. 1317–1329.
1148:10.2165/00003495-200363190-00010
852:, as an inexpensive adjuvant to
673:
670:
664:
49:
40:
4008:Monoamine metabolism modulators
1728:Drug Metabolism and Disposition
1686:Drug Metabolism and Disposition
1329:Fischer J, Ganellin CR (2006).
944:At very high doses, is also an
821:Desloratadine is used to treat
754:Key:JAUOIFJMECXRGI-UHFFFAOYSA-N
68:Clarinex, Aerius, Allex, others
2191:Tripelennamine (pyribenzamine)
1657:. 3 April 2006. Archived from
921:Desloratadine is a selective H
658:
1:
4013:Monoamine reuptake inhibitors
4003:Receptor/signaling modulators
1514:Expert Opinion on Drug Safety
1332:Analogue-based Drug Discovery
1177:Schering Corporation (2000).
378:Similar amount into the feces
5698:Peripherally selective drugs
2065:Phenylpyridinylpropanamines:
1616:10.1097/WOX.0b013e3182093e19
1526:10.1517/14740338.2013.788148
831:chronic idiopathic urticaria
779:. sold under the brand name
5580:Merck Headquarters Building
3636:Quisultazine (quisultidine)
3283:Tetracyclic antidepressants
1988:Diphenylmethanolpiperidines
948:at various subtypes of the
5729:
4679:Carfenazine (carphenazine)
2599:Benzatropine (benztropine)
648:Chemical and physical data
4408:Northiaden (nordosulepin)
4146:Tricyclic antidepressants
3995:
3313:Tricyclic antidepressants
3169:Sequifenadine (bicarphen)
2006:Diphenylmethylpiperazines
1932:Diarylmethoxyalkylamines:
1802:10.1136/bmj.320.7243.1184
1655:European Medicines Agency
1570:European Medicines Agency
1486:10.1016/j.det.2015.11.008
1367:American Family Physician
1274:European Medicines Agency
762:
737:
717:
387:
48:
39:
5678:Benzocycloheptapyridines
4551:Hydroxyethylpromethazine
2951:Second/third-generation:
2784:Hydroxyethylpromethazine
2278:Hydroxyethylpromethazine
403:-benzocycloheptapyridine
76:descarboethoxyloratadine
5688:H1 receptor antagonists
5037:Eslicarbazepine acetate
4243:Depramine (balipramine)
3591:Lavoltidine (loxtidine)
3204:Atypical antipsychotics
3149:Quifenadine (phencarol)
2814:Mepyramine (pyrilamine)
2574:4-Methyldiphenhydramine
2451:Mepyramine (pyrilamine)
2171:Mepyramine (pyrilamine)
1361:See S (November 2003).
884:Co-administration with
5693:Human drug metabolites
5363:Cubist Pharmaceuticals
4939:Savoxepin/Cipazoxapine
4126:Pyridinobenzodiazepine
3367:Typical antipsychotics
1741:10.1124/dmd.115.065011
1698:10.1124/dmd.114.062620
1008:central nervous system
995:
929:which functions as an
794:that is used to treat
333:3-Hydroxydesloratadine
5520:Ezetimibe/simvastatin
5414:Ezetimibe/simvastatin
5368:H. K. Mulford Company
5283:Merck & Co., Inc.
4273:Dosulepin (dothiepin)
4258:Desmethyltrimipramine
4253:Desmethylclomipramine
4248:(desmethylimipramine)
4121:Pyridazinobenzoxazine
3333:dosulepin (dothiepin)
1065:, and not to inhibit
1033:, and not to inhibit
989:
2210:Dibenzocycloheptenes
1474:Dermatologic Clinics
5290:Corporate directors
4086:Dibenzocycloheptene
2714:Dexchlorpheniramine
2527:2-Pyridylethylamine
2088:Dexchlorpheniramine
1796:(7243): 1184–1186.
1298:Clinical Immunology
1000:blood–brain barrier
837:). It is the major
783:among others, is a
255:(Prescription only)
231:(Pharmacy medicine)
36:
5545:Rocuronium bromide
5469:rVSV-ZEBOV vaccine
2779:Homochlorcyclizine
2709:Dexbrompheniramine
2498:Histamine receptor
2078:Dexbrompheniramine
1249:. 14 November 2022
1223:. 14 November 2022
996:
362:Duration of action
27:Allergy medication
5643:
5642:
5604:The Merck Manuals
5568:
5567:
5249:
5248:
4178:Amitriptylinoxide
4096:Dibenzothiazepine
4021:
4020:
3991:
3990:
3919:α-Methylhistamine
3914:4-Methylhistamine
3890:
3889:
3713:α-Methylhistamine
3689:
3688:
3458:
3457:
3407:Unknown/unsorted:
3265:hydroxynefazodone
2571:First-generation:
2464:
2463:
2377:Phenylpiperazines
1443:10.1111/jdv.12403
1437:(12): 1654–1660.
1373:(10): 2015–2016.
1142:(19): 2051–2077.
1115:poor metabolizers
823:allergic rhinitis
800:active metabolite
774:
773:
708:Interactive image
598:CompTox Dashboard
275:
263:
250:
238:
226:
158:
125:
16:(Redirected from
5720:
5660:
5659:
5658:
5651:
5495:
5358:Acceleron Pharma
5317:Rochelle Lazarus
5307:William Harrison
5276:
5269:
5262:
5253:
5072:Anticholinergics
4954:Thiethylperazine
4919:Prochlorperazine
4150:
4091:Dibenzodiazepine
4048:
4041:
4034:
4025:
3931:
3904:
3745:
3703:
3514:
3472:
3391:prochlorperazine
3258:Phenylpiperazine
2874:Phenyltoloxamine
2734:Diphenylpyraline
2654:Chlorphenoxamine
2549:
2517:
2491:
2484:
2477:
2468:
2421:Chlorphenoxamine
2148:Ethylenediamines
2123:Phenyltoloxamine
2082:+pseudoephedrine
1965:Diphenylpyraline
1945:Chlorphenoxamine
1882:
1880:
1854:
1847:
1840:
1831:
1824:
1823:
1813:
1781:
1775:
1773:
1768:: Desloratadine
1763:
1754:
1753:
1743:
1734:(9): 1294–1302.
1719:
1710:
1709:
1680:
1674:
1673:
1671:
1669:
1664:on 16 March 2018
1663:
1652:
1644:
1638:
1637:
1627:
1595:
1589:
1588:
1586:
1584:
1578:
1572:. Archived from
1567:
1559:
1546:
1545:
1509:
1498:
1497:
1469:
1463:
1462:
1426:
1420:
1419:
1417:
1415:
1401:
1395:
1394:
1392:
1390:
1381:. Archived from
1358:
1347:
1346:
1326:
1320:
1319:
1293:
1280:
1279:
1265:
1259:
1258:
1256:
1254:
1239:
1233:
1232:
1230:
1228:
1213:
1200:
1199:
1194:
1192:
1183:
1174:
1168:
1167:
1131:
1111:Caucasian people
1105:Pharmacogenomics
956:Pharmacokinetics
917:Pharmacodynamics
827:nasal congestion
770:
769:
710:
690:
675:
672:
666:
660:
643:
632:
621:
620:
606:
604:
589:
569:
549:
529:
509:
489:
469:
449:
439:
438:
424:
352:
297:Rapidly absorbed
273:
270:
261:
258:
248:
245:
237:
234:
224:
221:
199:
156:
153:
135:
124:
121:
108:
94:
53:
44:
37:
35:
21:
5728:
5727:
5723:
5722:
5721:
5719:
5718:
5717:
5668:
5667:
5666:
5656:
5654:
5646:
5644:
5639:
5584:
5564:
5505:Coppertone sign
5498:Schering-Plough
5493:
5382:
5373:Schering-Plough
5346:
5285:
5280:
5250:
5245:
5136:Cyclobenzaprine
5089:
5066:
5032:Eslicarbazepine
5014:Anticonvulsants
5008:
4989:Triflupromazine
4984:Trifluoperazine
4849:Octomethothepin
4694:Chlorprothixene
4635:
4556:Isopromethazine
4487:
4398:Norbutriptyline
4148:
4143:
4141:Antidepressants
4135:
4106:Dibenzoxazepine
4057:
4052:
4022:
4017:
3987:
3946:
3929:
3899:
3886:
3760:
3743:
3698:
3685:
3524:
3512:
3467:
3454:
3261:antidepressants
2794:Isopromethazine
2729:Diphenhydramine
2614:Brompheniramine
2559:
2547:
2512:
2503:
2495:
2465:
2460:
2436:Diphenhydramine
2395:
2381:Antidepressants
2365:
2313:Antidepressants
2215:Antidepressants
2195:
2142:
2068:Brompheniramine
1955:Diphenhydramine
1918:
1876:
1868:
1858:
1828:
1827:
1783:
1782:
1778:
1764:
1757:
1721:
1720:
1713:
1682:
1681:
1677:
1667:
1665:
1661:
1650:
1646:
1645:
1641:
1597:
1596:
1592:
1582:
1580:
1576:
1565:
1561:
1560:
1549:
1511:
1510:
1501:
1471:
1470:
1466:
1428:
1427:
1423:
1413:
1411:
1405:"Desloratadine"
1403:
1402:
1398:
1388:
1386:
1385:on 24 July 2005
1360:
1359:
1350:
1343:
1328:
1327:
1323:
1316:
1295:
1294:
1283:
1267:
1266:
1262:
1252:
1250:
1241:
1240:
1236:
1226:
1224:
1215:
1214:
1203:
1190:
1188:
1181:
1176:
1175:
1171:
1133:
1132:
1128:
1123:
1107:
1015:cytochrome P450
966:plasma proteins
958:
938:
931:inverse agonist
924:
919:
914:
882:
862:
819:
811:Schering-Plough
792:inverse agonist
791:
765:
763:
758:
755:
750:
745:
744:
733:
730:
725:
724:
713:
688:
678:
669:
663:
624:
600:
592:
572:
552:
532:
512:
492:
472:
452:
435:
427:
407:
404:
395:
394:
377:
350:
339:Onset of action
303:Protein binding
293:Bioavailability
285:Pharmacokinetic
279:
203:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
5726:
5724:
5716:
5715:
5710:
5705:
5700:
5695:
5690:
5685:
5680:
5670:
5669:
5665:
5664:
5641:
5640:
5638:
5637:
5636:
5635:
5628:
5621:
5614:
5600:
5592:
5590:
5586:
5585:
5583:
5582:
5576:
5574:
5570:
5569:
5566:
5565:
5563:
5562:
5560:Urofollitropin
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5507:
5501:
5499:
5492:
5491:
5486:
5481:
5476:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5390:
5388:
5384:
5383:
5381:
5380:
5375:
5370:
5365:
5360:
5354:
5352:
5348:
5347:
5345:
5344:
5339:
5334:
5329:
5324:
5319:
5314:
5312:William Kelley
5309:
5304:
5302:Johnnetta Cole
5299:
5293:
5291:
5287:
5286:
5281:
5279:
5278:
5271:
5264:
5256:
5247:
5246:
5244:
5243:
5238:
5233:
5228:
5223:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
5163:
5161:Methylene blue
5158:
5153:
5148:
5143:
5138:
5133:
5128:
5123:
5118:
5113:
5108:
5106:Aminopromazine
5103:
5097:
5095:
5091:
5090:
5088:
5087:
5082:
5076:
5074:
5068:
5067:
5065:
5064:
5059:
5054:
5049:
5044:
5039:
5034:
5029:
5024:
5018:
5016:
5010:
5009:
5007:
5006:
5004:Zuclopenthixol
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4904:Piperacetazine
4901:
4896:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4789:Isofloxythepin
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4716:
4711:
4706:
4701:
4696:
4691:
4689:Chlorpromazine
4686:
4681:
4676:
4671:
4666:
4661:
4656:
4651:
4649:Acetophenazine
4645:
4643:
4641:Antipsychotics
4637:
4636:
4634:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4533:
4528:
4523:
4518:
4516:Cyproheptadine
4513:
4508:
4503:
4497:
4495:
4493:Antihistamines
4489:
4488:
4486:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4425:
4420:
4415:
4410:
4405:
4400:
4395:
4390:
4385:
4380:
4375:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4313:Imipraminoxide
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4233:Cyanodothiepin
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4154:
4152:
4137:
4136:
4134:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4101:Dibenzothiepin
4098:
4093:
4088:
4083:
4078:
4073:
4067:
4065:
4059:
4058:
4053:
4051:
4050:
4043:
4036:
4028:
4019:
4018:
4016:
4015:
4010:
4005:
4000:
3996:
3993:
3992:
3989:
3988:
3986:
3985:
3980:
3975:
3970:
3965:
3960:
3954:
3952:
3948:
3947:
3945:
3944:
3939:
3934:
3926:
3921:
3916:
3910:
3908:
3901:
3897:
3892:
3891:
3888:
3887:
3885:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3842:Iodophenpropit
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3774:
3768:
3766:
3762:
3761:
3759:
3758:
3753:
3748:
3740:
3735:
3730:
3725:
3720:
3715:
3709:
3707:
3700:
3696:
3691:
3690:
3687:
3686:
3684:
3683:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3532:
3530:
3526:
3525:
3523:
3522:
3517:
3509:
3504:
3499:
3494:
3489:
3484:
3478:
3476:
3469:
3465:
3460:
3459:
3456:
3455:
3453:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3403:
3402:
3371:chlorpromazine
3364:
3310:
3280:
3255:
3197:
3196:
3191:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3084:Levocetirizine
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3026:
3024:Clobenztropine
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2956:
2947:
2946:
2941:
2939:Tripelennamine
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2774:Histapyrrodine
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2719:Dimenhydrinate
2716:
2711:
2706:
2701:
2696:
2691:
2689:Cyproheptadine
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2649:Chlorphenamine
2646:
2641:
2639:Chloropyramine
2636:
2634:Chlorcyclizine
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2567:
2565:
2561:
2560:
2558:
2557:
2552:
2544:
2539:
2534:
2529:
2523:
2521:
2514:
2510:
2505:
2504:
2496:
2494:
2493:
2486:
2479:
2471:
2462:
2461:
2459:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2416:Chloropyramine
2413:
2407:
2405:
2397:
2396:
2394:
2393:
2388:
2373:
2371:
2367:
2366:
2364:
2363:
2358:
2353:
2348:
2343:
2338:
2333:
2328:
2306:
2305:
2300:
2295:
2290:
2285:
2280:
2275:
2270:
2263:Phenothiazines
2258:
2257:
2252:
2247:
2242:
2237:
2232:
2230:Cyproheptadine
2227:
2222:
2205:
2203:
2197:
2196:
2194:
2193:
2188:
2183:
2178:
2173:
2168:
2166:Histapyrrodine
2163:
2161:Chloropyramine
2158:
2152:
2150:
2144:
2143:
2141:
2140:
2135:
2130:
2125:
2120:
2115:
2110:
2101:
2100:
2095:
2092:+betamethasone
2085:
2075:
2073:Chlorphenamine
2070:
2061:
2060:
2055:
2050:
2045:
2040:
2035:
2030:
2028:Chlorcyclizine
2025:
2024:
2023:
2021:Levocetirizine
2013:
2001:
2000:
1995:
1983:
1982:
1977:
1972:
1967:
1962:
1952:
1947:
1942:
1937:
1928:
1926:
1924:Diarylmethanes
1920:
1919:
1917:
1916:
1911:
1906:
1901:
1896:
1891:
1885:
1883:
1874:Benzimidazoles
1870:
1869:
1861:Antihistamines
1859:
1857:
1856:
1849:
1842:
1834:
1826:
1825:
1776:
1755:
1711:
1692:(4): 523–533.
1675:
1639:
1590:
1579:on 5 July 2019
1547:
1499:
1480:(2): 147–157.
1464:
1421:
1396:
1348:
1341:
1321:
1314:
1281:
1278:. 19 May 2004.
1260:
1234:
1201:
1169:
1125:
1124:
1122:
1119:
1106:
1103:
957:
954:
936:
922:
918:
915:
913:
910:
881:
878:
861:
858:
818:
815:
789:
772:
771:
760:
759:
757:
756:
753:
751:
748:
740:
739:
738:
735:
734:
732:
731:
728:
720:
719:
718:
715:
714:
712:
711:
703:
701:
693:
692:
686:
680:
679:
676:
667:
661:
656:
650:
649:
645:
644:
634:
626:
625:
623:
622:
609:
607:
594:
593:
591:
590:
582:
580:
574:
573:
571:
570:
562:
560:
554:
553:
551:
550:
542:
540:
534:
533:
531:
530:
522:
520:
514:
513:
511:
510:
502:
500:
494:
493:
491:
490:
482:
480:
474:
473:
471:
470:
462:
460:
454:
453:
451:
450:
442:
440:
429:
428:
426:
425:
417:
415:
409:
408:
406:
405:
398:
390:
389:
388:
385:
384:
380:
379:
374:
368:
367:
366:up to 24 hours
364:
358:
357:
354:
345:
344:
341:
335:
334:
331:
325:
324:
315:
309:
308:
305:
299:
298:
295:
289:
288:
281:
280:
278:
277:
268:
256:
243:
232:
218:
216:
210:
209:
205:
204:
202:
201:
188:
186:
180:
179:
174:
172:administration
166:
165:
163:
162:
160:
150:
148:
140:
139:
137:
136:
118:
116:
110:
109:
102:
96:
95:
88:
78:
77:
74:
70:
69:
66:
60:
59:
55:
54:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5725:
5714:
5711:
5709:
5706:
5704:
5701:
5699:
5696:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5675:
5673:
5663:
5653:
5649:
5634:
5633:
5629:
5627:
5626:
5622:
5620:
5619:
5615:
5613:
5612:
5608:
5607:
5606:
5605:
5601:
5599:
5598:
5594:
5593:
5591:
5587:
5581:
5578:
5577:
5575:
5571:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5511:
5510:Desloratadine
5508:
5506:
5503:
5502:
5500:
5496:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5424:Fosaprepitant
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5391:
5389:
5385:
5379:
5376:
5374:
5371:
5369:
5366:
5364:
5361:
5359:
5356:
5355:
5353:
5349:
5343:
5342:Peter Wendell
5340:
5338:
5337:Wendell Weeks
5335:
5333:
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5297:Richard Clark
5295:
5294:
5292:
5288:
5284:
5277:
5272:
5270:
5265:
5263:
5258:
5257:
5254:
5242:
5239:
5237:
5234:
5232:
5229:
5227:
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5122:
5119:
5117:
5114:
5112:
5109:
5107:
5104:
5102:
5099:
5098:
5096:
5092:
5086:
5083:
5081:
5078:
5077:
5075:
5073:
5069:
5063:
5060:
5058:
5057:Oxitriptyline
5055:
5053:
5052:Oxcarbazepine
5050:
5048:
5047:Licarbazepine
5045:
5043:
5040:
5038:
5035:
5033:
5030:
5028:
5025:
5023:
5022:Carbamazepine
5020:
5019:
5017:
5015:
5011:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4959:Thiopropazate
4957:
4955:
4952:
4950:
4947:
4945:
4944:Sulforidazine
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4874:Peradithiepin
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4814:Meperathiepin
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4744:Docloxythepin
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4646:
4644:
4642:
4638:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4531:Desloratadine
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4507:
4504:
4502:
4499:
4498:
4496:
4494:
4490:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4448:Protriptyline
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4429:
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4393:Nitroxazepine
4391:
4389:
4388:Monometacrine
4386:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4238:Demexiptiline
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4194:
4191:
4189:
4186:
4184:
4181:
4179:
4176:
4174:
4173:Amitriptyline
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4155:
4153:
4147:
4142:
4138:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4116:Phenothiazine
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4081:Dibenzazepine
4079:
4077:
4074:
4072:
4069:
4068:
4066:
4064:
4060:
4056:
4049:
4044:
4042:
4037:
4035:
4030:
4029:
4026:
4014:
4011:
4009:
4006:
4004:
4001:
3998:
3997:
3994:
3984:
3981:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3955:
3953:
3949:
3943:
3940:
3938:
3935:
3933:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3911:
3909:
3905:
3902:
3900:
3893:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3767:
3763:
3757:
3754:
3752:
3749:
3747:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3710:
3708:
3704:
3701:
3699:
3692:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3533:
3531:
3527:
3521:
3518:
3516:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3479:
3477:
3473:
3470:
3468:
3461:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3405:
3404:
3400:
3396:
3392:
3388:
3384:
3380:
3376:
3372:
3368:
3365:
3362:
3358:
3357:protriptyline
3354:
3353:nortriptyline
3350:
3346:
3342:
3338:
3334:
3330:
3326:
3322:
3318:
3317:amitriptyline
3314:
3311:
3308:
3304:
3300:
3296:
3292:
3288:
3284:
3281:
3278:
3277:triazoledione
3274:
3270:
3266:
3262:
3259:
3256:
3253:
3249:
3245:
3241:
3237:
3233:
3229:
3225:
3221:
3220:brilaroxazine
3217:
3216:brexpiprazole
3213:
3209:
3205:
3202:
3199:
3198:
3195:
3192:
3190:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3079:Levocabastine
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3029:Desloratadine
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2949:
2948:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2919:Thenyldiamine
2917:
2915:
2912:
2910:
2907:
2905:
2904:Pyrrobutamine
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2829:Methapyrilene
2827:
2825:
2824:Methafurylene
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2629:Carbinoxamine
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2569:
2568:
2566:
2562:
2556:
2553:
2551:
2545:
2543:
2540:
2538:
2535:
2533:
2530:
2528:
2525:
2524:
2522:
2518:
2515:
2513:
2506:
2502:
2499:
2492:
2487:
2485:
2480:
2478:
2473:
2472:
2469:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2408:
2406:
2403:
2398:
2392:
2391:Phenbenzamine
2389:
2386:
2382:
2378:
2375:
2374:
2372:
2368:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2326:
2322:
2318:
2314:
2311:
2308:
2307:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2265:
2264:
2260:
2259:
2256:
2253:
2251:
2248:
2246:
2243:
2241:
2240:Desloratadine
2238:
2236:
2233:
2231:
2228:
2226:
2223:
2220:
2219:amitriptyline
2216:
2212:
2211:
2207:
2206:
2204:
2202:
2198:
2192:
2189:
2187:
2184:
2182:
2181:Phenbenzamine
2179:
2177:
2176:Methapyrilene
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2153:
2151:
2149:
2145:
2139:
2136:
2134:
2131:
2129:
2128:Pyrrobutamine
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2103:
2102:
2099:
2096:
2093:
2089:
2086:
2083:
2079:
2076:
2074:
2071:
2069:
2066:
2063:
2062:
2059:
2056:
2054:
2051:
2049:
2046:
2044:
2041:
2039:
2036:
2034:
2031:
2029:
2026:
2022:
2019:
2018:
2017:
2014:
2012:
2008:
2007:
2003:
2002:
1999:
1996:
1994:
1990:
1989:
1985:
1984:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1960:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1940:Carbinoxamine
1938:
1936:
1933:
1930:
1929:
1927:
1925:
1921:
1915:
1912:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1886:
1884:
1875:
1871:
1866:
1862:
1855:
1850:
1848:
1843:
1841:
1836:
1835:
1832:
1821:
1817:
1812:
1807:
1803:
1799:
1795:
1791:
1787:
1780:
1777:
1772:
1767:
1762:
1760:
1756:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1718:
1716:
1712:
1707:
1703:
1699:
1695:
1691:
1687:
1679:
1676:
1660:
1656:
1649:
1643:
1640:
1635:
1631:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1594:
1591:
1575:
1571:
1564:
1558:
1556:
1554:
1552:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1515:
1508:
1506:
1504:
1500:
1495:
1491:
1487:
1483:
1479:
1475:
1468:
1465:
1460:
1456:
1452:
1448:
1444:
1440:
1436:
1432:
1425:
1422:
1410:
1406:
1400:
1397:
1384:
1380:
1376:
1372:
1368:
1364:
1357:
1355:
1353:
1349:
1344:
1342:9783527607495
1338:
1334:
1333:
1325:
1322:
1317:
1315:9780323044042
1311:
1307:
1303:
1299:
1292:
1290:
1288:
1286:
1282:
1277:
1275:
1270:
1264:
1261:
1248:
1244:
1238:
1235:
1222:
1218:
1212:
1210:
1208:
1206:
1202:
1198:
1187:
1180:
1173:
1170:
1165:
1161:
1157:
1153:
1149:
1145:
1141:
1137:
1130:
1127:
1120:
1118:
1116:
1112:
1104:
1102:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1011:
1009:
1005:
1001:
993:
988:
984:
982:
978:
974:
969:
967:
963:
955:
953:
951:
947:
942:
940:
932:
928:
927:antihistamine
916:
911:
909:
907:
903:
899:
895:
891:
887:
879:
877:
875:
871:
867:
859:
857:
855:
851:
846:
844:
840:
836:
832:
828:
824:
816:
814:
812:
807:
805:
801:
797:
793:
786:
782:
778:
777:Desloratadine
768:
761:
752:
747:
743:
736:
727:
723:
716:
709:
705:
704:
702:
699:
694:
687:
685:
681:
657:
655:
651:
646:
642:
638:
635:
633:
631:ECHA InfoCard
627:
619:
615:
614:DTXSID1044196
611:
610:
608:
599:
595:
588:
584:
583:
581:
579:
575:
568:
564:
563:
561:
559:
555:
548:
544:
543:
541:
539:
535:
528:
524:
523:
521:
519:
515:
508:
504:
503:
501:
499:
495:
488:
484:
483:
481:
479:
475:
468:
464:
463:
461:
459:
455:
448:
444:
443:
441:
434:
430:
423:
419:
418:
416:
414:
410:
402:
397:
393:
386:
381:
375:
373:
369:
365:
363:
359:
355:
353:
346:
343:within 1 hour
342:
340:
336:
332:
330:
326:
323:
319:
316:
314:
310:
306:
304:
300:
296:
294:
290:
286:
282:
276: Rx-only
269:
267:
257:
254:
244:
242:
233:
230:
220:
219:
217:
215:
211:
206:
198:
193:
190:
189:
187:
185:
181:
178:
175:
173:
167:
161:
152:
151:
149:
147:
141:
134:
133:Desloratadine
129:
120:
119:
117:
115:
111:
107:
103:
101:
97:
93:
89:
87:
83:
79:
75:
71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
34:Desloratadine
30:
19:
5683:Chloroarenes
5631:
5624:
5617:
5610:
5602:
5595:
5589:Publications
5550:Temozolomide
5509:
5449:Omarigliptin
5351:Subsidiaries
5332:Samuel Thier
5327:Anne Tatlock
5322:Thomas Shenk
5226:Siltenzepine
5121:Benzoctamine
5062:Rispenzepine
4994:Trifluthepin
4964:Thioridazine
4929:Prothipendyl
4889:Perphenazine
4864:Oxyprothepin
4859:Oxyclothepin
4819:Mesoridazine
4784:Homopipramol
4774:Fluphenazine
4709:Clocapramine
4684:Carpipramine
4674:Butaperazine
4631:Thiazinamium
4621:Propiomazine
4616:Promethazine
4606:Phenindamine
4591:Methdilazine
4571:Latrepirdine
4561:Isothipendyl
4530:
4483:Trimipramine
4478:Tienopramine
4453:Quinupramine
4423:Octriptyline
4318:Intriptyline
4303:Homopipramol
4228:Cotriptyline
4223:Clomipramine
4208:Cianopramine
4203:Butriptyline
4131:Thioxanthene
4111:Dibenzoxepin
3973:Thioperamide
3877:Thioperamide
3817:Clobenpropit
3738:Immethridine
3641:Ramixotidine
3611:Niperotidine
3576:Isolamtidine
3536:Bisfentidine
3445:Trelnarizine
3425:Flotrenizine
3406:
3395:thioridazine
3387:perphenazine
3379:fluphenazine
3375:flupenthixol
3361:trimipramine
3325:clomipramine
3321:butriptyline
3307:oxaprotiline
3236:paliperidone
3208:aripiprazole
3200:
3144:Piclopastine
3074:Latrepirdine
3064:Flezelastine
3059:Fexofenadine
3044:Efletirizine
3028:
2950:
2944:Triprolidine
2934:Tolpropamine
2929:Thonzylamine
2924:Thiazinamium
2899:Propiomazine
2894:Promethazine
2864:Phenindamine
2844:Orphenadrine
2834:Methdilazine
2799:Isothipendyl
2749:Etodroxizine
2679:Cloperastine
2570:
2456:Promethazine
2446:Isothipendyl
2376:
2356:Phenindamine
2336:Latrepirdine
2325:trimipramine
2309:
2303:Promethazine
2293:Methdilazine
2283:Isothipendyl
2261:
2239:
2208:
2138:Triprolidine
2104:
2064:
2043:Etodroxizine
2004:
1993:Fexofenadine
1986:
1980:Orphenadrine
1931:
1793:
1789:
1779:
1731:
1727:
1689:
1685:
1678:
1666:. Retrieved
1659:the original
1642:
1610:(2): 47–53.
1607:
1603:
1593:
1581:. Retrieved
1574:the original
1517:
1513:
1477:
1473:
1467:
1434:
1430:
1424:
1412:. Retrieved
1408:
1399:
1387:. Retrieved
1383:the original
1370:
1366:
1331:
1324:
1297:
1272:
1269:"Allex EPAR"
1263:
1251:. Retrieved
1246:
1237:
1225:. Retrieved
1220:
1196:
1189:. Retrieved
1185:
1172:
1139:
1135:
1129:
1108:
1012:
997:
970:
962:blood plasma
959:
943:
920:
912:Pharmacology
894:azithromycin
890:ketoconazole
886:erythromycin
883:
880:Interactions
863:
860:Side effects
854:isotretinoin
847:
820:
817:Medical uses
808:
780:
776:
775:
764:
567:CHEBI:291342
400:
349:Elimination
214:Legal status
208:Legal status
114:License data
29:
5703:Piperidines
5525:Famciclovir
5479:Sitagliptin
5474:Simvastatin
5459:Rizatriptan
5454:Raltegravir
5444:Montelukast
5419:Finasteride
5394:Alendronate
5241:Zolenzepine
5231:Telenzepine
5201:Pirenzepine
5186:Pipazethate
5171:Nuvenzepine
5156:Fluradoline
5146:Darenzepine
5085:Tropatepine
5080:Profenamine
5027:Dizocilpine
4979:Traboxopine
4969:Thiothixene
4909:Pipotiazine
4894:Periciazine
4879:Perathiepin
4839:Mosapramine
4779:Gevotroline
4769:Flupentixol
4759:Flumezapine
4739:Doclothepin
4734:Cyanothepin
4719:Clorotepine
4654:Alimemazine
4611:Pimethixene
4601:Oxomemazine
4596:Olopatadine
4586:Mequitazine
4581:Mebhydrolin
4546:Fenethazine
4541:Etymemazine
4511:Clobenzepam
4443:Propizepine
4438:Pirandamine
4418:Noxiptiline
4383:Mirtazapine
4373:Metapramine
4358:Mariptiline
4353:Maprotiline
4338:Lofepramine
4328:Ketipramine
4283:Enprazepine
4268:Dimetacrine
4213:Ciclazindol
3958:JNJ-7777120
3951:Antagonists
3862:PF-03654746
3857:NNC 38-1049
3852:JNJ-5207852
3837:Impentamine
3802:Betahistine
3765:Antagonists
3718:Cipralisant
3681:Zolantidine
3671:Venritidine
3606:Mifentidine
3551:Dalcotidine
3529:Antagonists
3507:Impromidine
3435:Napactadine
3399:thiothixene
3349:lofepramine
3329:desipramine
3303:mirtazapine
3295:maprotiline
3248:ziprasidone
3244:risperidone
3228:iloperidone
3184:Terfenadine
3179:Temelastine
3129:Olopatadine
3119:Noberastine
3109:Mizolastine
3104:Mebhydrolin
3099:Mapinastine
3089:Linetastine
3004:Carebastine
2989:Bepotastine
2974:Bamirastine
2954:Acrivastine
2914:Thenalidine
2879:Pimethixene
2869:Pheniramine
2854:Oxomemazine
2819:Mequitazine
2809:Medrylamine
2789:Hydroxyzine
2769:Flunarizine
2764:Fenethazine
2759:Etymemazine
2724:Dimetindene
2699:Decloxizine
2674:Clocinizine
2669:Clobenzepam
2659:Cinnarizine
2604:Bepotastine
2579:Alimemazine
2564:Antagonists
2532:Betahistine
2431:Dimetindene
2361:Pimethixene
2346:Olopatadine
2341:Mebhydrolin
2321:mirtazapine
2298:Oxomemazine
2288:Mequitazine
2273:Fenethazine
2268:Alimemazine
2186:Thenalidine
2133:Quifenadine
2118:Dimetindene
2108:Acrivastine
2098:Pheniramine
2048:Hydroxyzine
2033:Cinnarizine
1998:Terfenadine
1909:Mizolastine
935:histamine H
798:. It is an
691: g·mol
637:100.166.554
422:100643-71-8
383:Identifiers
329:Metabolites
100:MedlinePlus
73:Other names
64:Trade names
5672:Categories
5632:Geriatrics
5625:Veterinary
5573:Facilities
5540:Mometasone
5535:Loratadine
5530:Infliximab
5489:Vorinostat
5484:Vericiguat
5439:Lovastatin
5399:Aprepitant
5378:Viralytics
5221:Serazapine
5211:Pitrazepin
5196:Pinadoline
5151:Elanzepine
5141:Damotepine
5126:Carvedilol
4974:Tilozepine
4949:Tenilapine
4934:Quetiapine
4914:Piquindone
4869:Pentiapine
4854:Olanzapine
4829:Metitepine
4804:Lurasidone
4764:Fluotracen
4754:Flucindole
4724:Clotiapine
4704:Citatepine
4699:Ciclindole
4669:Butaclamol
4626:Rupatadine
4576:Loratadine
4536:Epinastine
4526:Deptropine
4521:Dacemazine
4473:Tianeptine
4468:Tampramine
4458:Spiroxepin
4433:Pipofezine
4403:Nordoxepin
4368:Melitracen
4308:Imipramine
4293:Fluotracen
4288:Fantridone
4263:Dibenzepin
4198:Batelapine
4193:Azepindole
4188:Aptazapine
4168:Amineptine
4076:Anthracene
4055:Tricyclics
3978:Toreforant
3968:Seliforant
3932:-Histidine
3867:Pitolisant
3847:Irdabisant
3832:GSK-189254
3812:Ciproxifan
3807:Burimamide
3751:Methimepip
3746:-Histidine
3666:Tuvatidine
3656:Sufotidine
3651:Roxatidine
3646:Ranitidine
3631:Pibutidine
3626:Oxmetidine
3616:Nizatidine
3596:Lupitidine
3581:Lafutidine
3571:Famotidine
3566:Etintidine
3561:Ebrotidine
3556:Donetidine
3546:Cimetidine
3541:Burimamide
3515:-Histidine
3440:Tagorizine
3430:GSK1004723
3420:Elbanizine
3415:Belarizine
3341:imipramine
3269:nefazodone
3240:quetiapine
3232:olanzapine
3189:Vapitadine
3159:Rupatadine
3139:Pibaxizine
3094:Loratadine
3054:Epinastine
3049:Emedastine
3014:Clemastine
3009:Cetirizine
2999:Cabastinen
2984:Bepiastine
2979:Barmastine
2969:Azelastine
2964:Astemizole
2959:Alinastine
2889:Pipoxizine
2739:Doxylamine
2704:Deptropine
2694:Dacemazine
2664:Clemastine
2644:Chlorothen
2624:Captodiame
2584:Antazoline
2550:-Histidine
2501:modulators
2426:Clemastine
2331:Epinastine
2255:Rupatadine
2250:Loratadine
2235:Deptropine
2201:Tricyclics
2156:Antazoline
2016:Cetirizine
1970:Doxylamine
1950:Clemastine
1904:Emedastine
1894:Azelastine
1889:Astemizole
1668:13 October
1583:21 January
1121:References
1004:drowsiness
992:metabolite
946:antagonist
906:metabolite
902:cimetidine
898:fluoxetine
872:(3%), and
843:loratadine
839:metabolite
804:loratadine
696:3D model (
684:Molar mass
587:ChEMBL1172
527:FVF865388R
498:ChemSpider
458:IUPHAR/BPS
413:CAS Number
392:IUPAC name
313:Metabolism
5515:Ezetimibe
5464:Rofecoxib
5429:Indinavir
5409:Ezetimibe
5404:Ertapenem
5236:Tipindole
5216:Pizotifen
5181:Perlapine
5176:Oxetorone
5166:Monatepil
5131:Cidoxepin
5116:Beloxepin
5111:Atiprosin
5101:Adosopine
5042:Etazepine
4924:Promazine
4899:Pinoxepin
4834:Metoxepin
4824:Metiapine
4809:Maroxepin
4749:Erizepine
4729:Clozapine
4714:Clomacran
4664:Asenapine
4659:Amoxapine
4566:Ketotifen
4506:Bisulepin
4501:Azatadine
4463:Tandamine
4428:Opipramol
4343:Losindole
4323:Iprindole
4298:Hepzidine
4218:Cidoxepin
4183:Amoxapine
4163:Amezepine
4158:Amoxapine
3963:Mianserin
3924:Histamine
3872:SCH-79687
3827:Enerisant
3822:Conessine
3723:Histamine
3676:Xaltidine
3661:Tiotidine
3621:Osutidine
3601:Metiamide
3586:Lamtidine
3497:Histamine
3482:Amthamine
3450:Trenizine
3345:iprindole
3299:mianserin
3287:amoxapine
3273:trazodone
3224:clozapine
3212:asenapine
3194:Zepastine
3174:Talastine
3164:Setastine
3154:Rocastine
3134:Perastine
3124:Octastine
3114:Moxastine
3069:Ketotifen
3034:Dorastine
3019:Clemizole
2994:Bilastine
2909:Talastine
2884:Piperoxan
2859:Perlapine
2849:Oxatomide
2839:Moxastine
2804:Meclozine
2744:Embramine
2684:Cyclizine
2619:Buclizine
2609:Bromazine
2589:Azatadine
2537:Histamine
2385:trazodone
2351:Perlapine
2245:Ketotifen
2225:Azatadine
2058:Oxatomide
2053:Meclizine
2038:Cyclizine
2011:Buclizine
1959:+naproxen
1914:Talastine
1899:Bilastine
1771:Monograph
1766:Drugs.com
1409:Drugs.com
1164:195689362
981:half-life
870:dry mouth
796:allergies
785:tricyclic
372:Excretion
351:half-life
307:83 to 87%
170:Routes of
144:Pregnancy
92:Monograph
86:Drugs.com
5662:Medicine
5555:Tibolone
5434:Losartan
5387:Products
5206:Pirolate
4999:Zotepine
4884:Perazine
4799:Loxapine
4378:Mezepine
4363:Mazindol
4348:Loxapine
4333:Litracen
4071:Acridine
3999:See also
3983:VUF-6002
3942:VUF-8430
3907:Agonists
3882:VUF-5681
3797:Bavisant
3777:A-423579
3772:A-349821
3756:Proxyfan
3706:Agonists
3492:Dimaprit
3487:Betazole
3475:Agonists
3410:Azanator
3383:loxapine
3291:loxapine
3252:zotepine
3039:Ebastine
2594:Bamipine
2520:Agonists
2411:Bamipine
2113:Bamipine
1975:Ebastine
1820:10784544
1750:26135009
1706:25595597
1634:23268457
1542:40472187
1534:23574541
1494:27015774
1451:25081735
1389:1 August
1379:14655812
1247:DailyMed
1221:DailyMed
1156:12962522
939:receptor
876:(0.6%).
874:headache
868:(1.2%),
781:Clarinex
767:(verify)
478:DrugBank
184:ATC code
177:By mouth
159: B1
146:category
128:DailyMed
18:Clarinex
4844:Naranol
4278:Doxepin
4063:Classes
3792:AZD5213
3787:ABT-652
3782:ABT-239
3733:Immepip
3520:UR-AK49
3369:(e.g.,
3337:doxepin
3315:(e.g.,
3285:(e.g.,
3263:(e.g.,
3206:(e.g.,
3201:Others:
2555:UR-AK49
2441:Doxepin
2402:topical
2383:(e.g.,
2317:doxepin
2315:(e.g.,
2310:Others:
2217:(e.g.,
2105:Others:
1625:3500039
1459:3406128
1091:UGT2B15
1059:UGT1A10
1055:UGT2B17
1051:UGT2B10
1047:CYP2C19
973:UGT2B10
933:at the
866:fatigue
654:Formula
487:DB00967
433:PubChem
318:UGT2B10
239::
200:)
194: (
192:R06AX27
130::
106:a602002
5648:Portal
5618:Manual
5094:Others
4149:(TCAs)
3937:OUP-16
3728:Imetit
2370:Others
1818:
1808:
1748:
1704:
1632:
1622:
1540:
1532:
1492:
1457:
1449:
1377:
1339:
1312:
1253:18 May
1227:18 May
1191:17 May
1186:US FDA
1162:
1154:
1109:2% of
1099:UGT1A8
1097:, and
1095:UGT1A7
1087:UGT2B7
1083:UGT1A9
1079:UGT1A6
1075:UGT1A4
1071:UGT1A3
1067:UGT1A1
1063:UGT2B4
1061:, and
1043:CYP2C9
1039:CYP2C8
1035:CYP1A2
1031:CYP3A5
1027:CYP3A4
1025:, and
1023:CYP2D6
1019:CYP2B6
977:CYP2C8
722:SMILES
689:310.83
578:ChEMBL
547:D03693
507:110575
447:124087
322:CYP2C8
266:℞-only
264:
251:
227:
126:
5611:Index
1811:27362
1662:(PDF)
1651:(PDF)
1577:(PDF)
1566:(PDF)
1538:S2CID
1455:S2CID
1414:4 May
1276:(EMA)
1182:(PDF)
1160:S2CID
1136:Drugs
1045:, or
900:, or
835:hives
742:InChI
698:JSmol
558:ChEBI
5191:P7C3
3502:HTMT
2542:HTMT
2400:For
1816:PMID
1746:PMID
1702:PMID
1670:2017
1630:PMID
1585:2022
1530:PMID
1490:PMID
1447:PMID
1416:2015
1391:2005
1375:PMID
1337:ISBN
1310:ISBN
1255:2024
1229:2024
1193:2024
1152:PMID
850:acne
829:and
538:KEGG
518:UNII
467:7157
287:data
82:AHFS
2404:use
1865:R06
1806:PMC
1798:doi
1794:320
1790:BMJ
1736:doi
1694:doi
1620:PMC
1612:doi
1522:doi
1482:doi
1439:doi
1302:doi
1144:doi
841:of
802:of
603:EPA
437:CID
253:POM
241:OTC
197:WHO
5674::
3397:,
3393:,
3389:,
3385:,
3381:,
3377:,
3373:,
3359:,
3355:,
3351:,
3347:,
3343:,
3339:,
3335:,
3331:,
3327:,
3323:,
3319:,
3305:,
3301:,
3297:,
3293:,
3289:,
3275:,
3271:,
3267:,
3250:,
3246:,
3242:,
3238:,
3234:,
3230:,
3226:,
3222:,
3218:,
3214:,
3210:,
2379::
2323:,
2319:,
2266::
2213::
2009::
1991::
1814:.
1804:.
1792:.
1788:.
1758:^
1744:.
1732:43
1730:.
1726:.
1714:^
1700:.
1690:43
1688:.
1653:.
1628:.
1618:.
1606:.
1602:.
1568:.
1550:^
1536:.
1528:.
1518:12
1516:.
1502:^
1488:.
1478:34
1476:.
1453:.
1445:.
1435:28
1433:.
1407:.
1371:68
1369:.
1365:.
1351:^
1308:.
1284:^
1271:.
1245:.
1219:.
1204:^
1195:.
1184:.
1158:.
1150:.
1140:63
1138:.
1101:.
1093:,
1089:,
1085:,
1081:,
1077:,
1073:,
1069:,
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