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Ampicillin/flucloxacillin

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The usual dose by mouth is one capsule of 250 mg 4 times a day in adults and half the adult dose as a syrup for children under the age of 10 years but over 2. For children below the age of 2 years, the oral dose is a quarter of the adult oral dose. Ampicillin/flucloxacillin is taken orally about
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family of antibiotics, so should not be taken by people allergic to penicillin. The combination is contraindicated in people with a history of flucloxacillin-associated jaundice/hepatic dysfunction and in people with
430:. Taking the contraceptive pill with ampicillin/flucloxacillin is safe unless vomiting or diarrhoea occurs and persists for more than one day, when extra contraceptive precautions would then be required. 297:
It is used to treat infections before the laboratory results confirm the causative organism. Side effects include stomach or bowel upsets. It should not be taken by people allergic to penicillin.
717: 1731: 111: 562: 710: 294:, both in equal amounts, available in a capsule and as a liquid, both taken by mouth, and as a formulation which can be given by injection into muscle or vein. 342: 703: 305:
The combination of ampicillin/flucloxacillin is typically given before laboratory results are known. Conditions for which it may be used include
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It is available in a capsule and a liquid, both taken by mouth, and as a formulation which can be given by injection into muscle or vein.
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Ampicillin/flucloxacillin is one of at least 63 β-lactam antibiotics developed in the forty years following the discovery of penicillin.
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Side effects are the same as per the individual components, with stomach or bowel upset from the flucloxacillin being the most common.
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It is generally safe in pregnancy. A trace amount in breast milk does not mean in cannot be used in breastfeeding mothers.
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Capsules contain 250 mg of each component, the syrup 125/125 mg per spoon, and the powder for reconstruction for
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and in people receiving immunosuppressive treatments, and to prevent infection after surgery.
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Insert into bacterial cell wall causing perforation and depolarization:
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Beta-Lactams: Novel Synthetic Pathways and Applications
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Benzathine benzylpenicillin/procaine benzylpenicillin
1903: 1853: 1832: 1808: 1799: 1699: 1639: 1606: 1574: 1556: 1528: 1495: 1360: 1267: 1179: 1158: 1092: 1058: 1029: 996: 937: 926: 877: 817: 806: 792: 750: 313:, throat, skin and soft tissue. It can be given in 214: 187: 167: 140: 135: 110: 91: 86: 74: 62: 57: 156: 149: 414:; who may have an increased chance of rashes. 711: 8: 661:Gray A, Wright J, Goodey V, Bruce L (2010). 32: 1805: 1176: 934: 814: 803: 789: 718: 704: 696: 596: 594: 592: 590: 488:. Edinburg, Texas: Springer. p. 106. 234: 176: 49: 40: 1839:Inhibits PG elongation and crosslinking: 475: 473: 471: 348:Co-fluampicil capsules and container (UK) 203: 196: 523: 521: 519: 517: 515: 513: 511: 509: 507: 505: 467: 338: 230: 557: 555: 553: 551: 398:It is given cautiously to people with 31: 626: 624: 622: 7: 642:from the original on 15 January 2021 123: 282:, is a combination drug of the two 375:Side effects and contraindications 25: 1864:subunit synthesis and transport: 531:British National Formulary (BNF) 353: 341: 81:β-lactam antibiotic (penicillin) 69:β-lactam antibiotic (penicillin) 681:from the original on 2023-01-12 1762:Imipenem/cilastatin/relebactam 386:Both parts are members of the 1: 412:chronic lymphocytic leukaemia 422:Interactions may occur with 1787:Ticarcillin/clavulanic acid 1707:Amoxicillin/clavulanic acid 844:Phenoxymethylpenicillin (V) 834:Benzathine benzylpenicillin 434:Pregnancy and breastfeeding 408:acute lymphocytic leukaemia 360:Co-fluampicil capsules (UK) 336:injection 250/250 mg. 2022: 424:blood thinning medications 383:or blood count may occur. 371:half an hour before food. 1951: 1712:Ampicillin/flucloxacillin 839:Procaine benzylpenicillin 404:cytomegalovirus infection 261:Ampicillin/flucloxacillin 246: 48: 39: 34:Ampicillin/flucloxacillin 667:. Pharmaceutical Press. 602:"Co-fluampicil capsules" 2001:Combination antibiotics 1777:Piperacillin/tazobactam 1737:Cefepime/enmetazobactam 307:infections in the chest 1868:synthesis inhibition ( 1752:Ceftolozane/tazobactam 1742:Cefoperazone/sulbactam 1641:β-lactamase inhibitors 664:Injectable Drugs Guide 275:), and sold under the 1782:Sulbactam/durlobactam 1767:Meropenem/vaborbactam 1747:Ceftazidime/avibactam 879:β-lactamase resistant 819:β-lactamase sensitive 484:. In Banik BK (ed.). 381:Effects on the kidney 1772:Panipenem/betamipron 1717:Ampicillin/sulbactam 829:Benzylpenicillin (G) 763:cell wall by binding 284:β-lactam antibiotics 1757:Imipenem/cilastatin 1727:Aztreonam/avibactam 1538:Ceftaroline fosamil 480:Tidwell TT (2017). 36: 1978:Never to phase III 1910:Hydrolyze NAM-NAG 998:Carboxypenicillins 761:layer of bacterial 757:(inhibit synthesis 575:on 16 January 2021 1988: 1987: 1849: 1848: 1795: 1794: 1602: 1601: 1384:Antipseudomonal ( 1292:Cefuroxime axetil 1088: 1087: 1084: 1083: 1031:Ureidopenicillins 922: 921: 786: 779: 775: 765:to and inhibiting 674:978-0-85369-787-9 541:978-0-85711-369-6 495:978-3-319-55621-5 258: 257: 216:CompTox Dashboard 16:(Redirected from 2013: 1806: 1177: 1033:(4th generation) 1000:(4th generation) 941:(3rd generation) 939:Aminopenicillins 935: 882:(2nd generation) 822:(1st generation) 815: 804: 790: 785: 777: 773: 759:of peptidoglycan 755: 720: 713: 706: 697: 690: 689: 687: 686: 658: 652: 651: 649: 647: 628: 617: 616: 614: 612: 598: 585: 584: 582: 580: 571:. Archived from 559: 546: 545: 528:"5. Infection". 525: 500: 499: 477: 357: 345: 267:) also known as 254: 253: 239: 238: 224: 222: 207: 200: 180: 160: 153: 127: 53: 44: 37: 35: 27:Combination drug 21: 2021: 2020: 2016: 2015: 2014: 2012: 2011: 2010: 1991: 1990: 1989: 1984: 1983: 1968:Clinical trials 1947: 1899: 1845: 1828: 1791: 1695: 1668:Clavulanic acid 1635: 1598: 1570: 1552: 1524: 1491: 1356: 1263: 1170: 1166: 1162: 1154: 1112:Antipseudomonal 1080: 1054: 1025: 992: 929: 918: 881: 873: 821: 809: 782:transpeptidases 781: 771: 766: 764: 762: 760: 758: 756: 754: 746: 724: 694: 693: 684: 682: 675: 660: 659: 655: 645: 643: 630: 629: 620: 610: 608: 600: 599: 588: 578: 576: 561: 560: 549: 542: 527: 526: 503: 496: 479: 478: 469: 464: 452: 444: 436: 420: 400:glandular fever 377: 368: 361: 358: 349: 346: 327: 319:puerperal fever 315:septic abortion 303: 249: 247: 242: 218: 210: 183: 163: 131: 94: 28: 23: 22: 15: 12: 11: 5: 2019: 2017: 2009: 2008: 2003: 1993: 1992: 1986: 1985: 1982: 1981: 1980: 1979: 1976: 1965: 1959: 1953: 1952: 1949: 1948: 1946: 1945: 1940: 1935: 1934: 1933: 1928: 1918: 1917: 1916: 1907: 1905: 1901: 1900: 1898: 1897: 1887: 1873: 1857: 1855: 1851: 1850: 1847: 1846: 1844: 1843: 1836: 1834: 1830: 1829: 1827: 1826: 1821: 1814: 1812: 1803: 1797: 1796: 1793: 1792: 1790: 1789: 1784: 1779: 1774: 1769: 1764: 1759: 1754: 1749: 1744: 1739: 1734: 1729: 1724: 1714: 1709: 1703: 1701: 1697: 1696: 1694: 1693: 1687: 1682: 1677: 1673:non-β-lactam ( 1671: 1661: 1655: 1645: 1643: 1637: 1636: 1634: 1633: 1628: 1623: 1618: 1612: 1610: 1604: 1603: 1600: 1599: 1597: 1596: 1591: 1586: 1580: 1578: 1572: 1571: 1569: 1568: 1562: 1560: 1554: 1553: 1551: 1550: 1545: 1540: 1534: 1532: 1530:5th generation 1526: 1525: 1523: 1522: 1517: 1512: 1507: 1501: 1499: 1497:4th generation 1493: 1492: 1490: 1489: 1483: 1474: 1469: 1464: 1459: 1454: 1449: 1444: 1439: 1434: 1429: 1424: 1419: 1414: 1409: 1404: 1399: 1394: 1388: 1382: 1377: 1372: 1366: 1364: 1362:3rd generation 1358: 1357: 1355: 1354: 1344: 1338: 1333: 1328: 1323: 1314: 1309: 1304: 1299: 1294: 1289: 1284: 1279: 1273: 1271: 1269:2nd generation 1265: 1264: 1262: 1261: 1256: 1251: 1246: 1241: 1236: 1231: 1226: 1221: 1216: 1211: 1206: 1201: 1196: 1191: 1185: 1183: 1181:1st generation 1174: 1164:Cephalosporins 1156: 1155: 1153: 1152: 1146: 1140: 1134: 1129: 1123: 1118: 1109: 1102: 1100: 1090: 1089: 1086: 1085: 1082: 1081: 1079: 1078: 1073: 1062: 1060: 1056: 1055: 1053: 1052: 1047: 1042: 1036: 1034: 1027: 1026: 1024: 1023: 1018: 1009: 1003: 1001: 994: 993: 991: 990: 985: 979: 974: 969: 964: 959: 950: 944: 942: 932: 924: 923: 920: 919: 917: 916: 911: 906: 901: 898:Flucloxacillin 895: 885: 883: 875: 874: 872: 871: 866: 861: 856: 851: 846: 841: 836: 831: 825: 823: 812: 801: 787: 748: 747: 729:active on the 727:Antibacterials 725: 723: 722: 715: 708: 700: 692: 691: 673: 653: 618: 586: 568:www.mims.co.uk 547: 540: 501: 494: 466: 465: 463: 460: 459: 458: 451: 448: 443: 440: 435: 432: 419: 416: 376: 373: 367: 364: 363: 362: 359: 352: 350: 347: 340: 326: 323: 302: 299: 292:flucloxacillin 256: 255: 244: 243: 241: 240: 232:DTXSID90894834 227: 225: 212: 211: 209: 208: 201: 193: 191: 185: 184: 182: 181: 173: 171: 165: 164: 162: 161: 154: 146: 144: 138: 137: 133: 132: 130: 129: 116: 114: 108: 107: 97: 95:administration 89: 88: 84: 83: 78: 76:Flucloxacillin 72: 71: 66: 60: 59: 58:Combination of 55: 54: 46: 45: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2018: 2007: 2004: 2002: 1999: 1998: 1996: 1977: 1975: 1972: 1971: 1969: 1966: 1963: 1960: 1958: 1955: 1954: 1950: 1944: 1941: 1939: 1936: 1932: 1929: 1927: 1924: 1923: 1922: 1919: 1915: 1912: 1911: 1909: 1908: 1906: 1902: 1895: 1891: 1888: 1885: 1881: 1877: 1874: 1871: 1867: 1863: 1859: 1858: 1856: 1854:Intracellular 1852: 1842: 1838: 1837: 1835: 1831: 1825: 1822: 1820: 1816: 1815: 1813: 1811: 1807: 1804: 1802: 1798: 1788: 1785: 1783: 1780: 1778: 1775: 1773: 1770: 1768: 1765: 1763: 1760: 1758: 1755: 1753: 1750: 1748: 1745: 1743: 1740: 1738: 1735: 1733: 1730: 1728: 1725: 1722: 1721:Sultamicillin 1718: 1715: 1713: 1710: 1708: 1705: 1704: 1702: 1698: 1691: 1688: 1686: 1683: 1681: 1678: 1676: 1672: 1669: 1665: 1662: 1659: 1656: 1654: 1650: 1647: 1646: 1644: 1642: 1638: 1632: 1629: 1627: 1624: 1622: 1619: 1617: 1614: 1613: 1611: 1609: 1605: 1595: 1592: 1590: 1587: 1585: 1582: 1581: 1579: 1577: 1573: 1567: 1564: 1563: 1561: 1559: 1555: 1549: 1546: 1544: 1541: 1539: 1536: 1535: 1533: 1531: 1527: 1521: 1518: 1516: 1513: 1511: 1508: 1506: 1503: 1502: 1500: 1498: 1494: 1487: 1484: 1482: 1478: 1475: 1473: 1470: 1468: 1465: 1463: 1460: 1458: 1455: 1453: 1450: 1448: 1445: 1443: 1440: 1438: 1435: 1433: 1430: 1428: 1425: 1423: 1420: 1418: 1415: 1413: 1410: 1408: 1405: 1403: 1400: 1398: 1395: 1392: 1389: 1387: 1383: 1381: 1378: 1376: 1373: 1371: 1368: 1367: 1365: 1363: 1359: 1352: 1348: 1345: 1342: 1339: 1337: 1336:Cefbuperazone 1334: 1332: 1329: 1327: 1324: 1322: 1318: 1315: 1313: 1310: 1308: 1305: 1303: 1300: 1298: 1295: 1293: 1290: 1288: 1285: 1283: 1280: 1278: 1275: 1274: 1272: 1270: 1266: 1260: 1257: 1255: 1252: 1250: 1247: 1245: 1242: 1240: 1237: 1235: 1232: 1230: 1227: 1225: 1222: 1220: 1217: 1215: 1212: 1210: 1207: 1205: 1202: 1200: 1197: 1195: 1192: 1190: 1187: 1186: 1184: 1182: 1178: 1175: 1173: 1169: 1165: 1161: 1157: 1150: 1147: 1145: 1141: 1138: 1135: 1133: 1130: 1127: 1124: 1122: 1119: 1117: 1113: 1110: 1108: 1105:Carbapenems ( 1104: 1103: 1101: 1099: 1095: 1091: 1077: 1076:Sulbenicillin 1074: 1071: 1070:Pivmecillinam 1067: 1064: 1063: 1061: 1057: 1051: 1048: 1046: 1043: 1041: 1038: 1037: 1035: 1032: 1028: 1022: 1019: 1017: 1016:Carindacillin 1013: 1012:Carbenicillin 1010: 1008: 1005: 1004: 1002: 999: 995: 989: 986: 983: 982:Talampicillin 980: 978: 977:Metampicillin 975: 973: 972:Lenampicillin 970: 968: 967:Bacampicillin 965: 963: 960: 958: 957:Pivampicillin 954: 951: 949: 946: 945: 943: 940: 936: 933: 931: 925: 915: 912: 910: 907: 905: 902: 899: 896: 894: 893:Dicloxacillin 890: 887: 886: 884: 880: 876: 870: 867: 865: 864:Clometocillin 862: 860: 857: 855: 854:Pheneticillin 852: 850: 847: 845: 842: 840: 837: 835: 832: 830: 827: 826: 824: 820: 816: 813: 811: 805: 802: 799: 795: 791: 788: 783: 769: 753: 749: 744: 740: 736: 732: 728: 721: 716: 714: 709: 707: 702: 701: 698: 680: 676: 670: 666: 665: 657: 654: 641: 637: 633: 627: 625: 623: 619: 607: 603: 597: 595: 593: 591: 587: 574: 570: 569: 564: 558: 556: 554: 552: 548: 543: 537: 533: 532: 524: 522: 520: 518: 516: 514: 512: 510: 508: 506: 502: 497: 491: 487: 483: 476: 474: 472: 468: 461: 457: 454: 453: 449: 447: 441: 439: 433: 431: 429: 425: 417: 415: 413: 409: 405: 401: 396: 394: 389: 384: 382: 374: 372: 365: 356: 351: 344: 339: 337: 335: 330: 324: 322: 320: 316: 312: 308: 300: 298: 295: 293: 289: 285: 281: 278: 274: 270: 269:co-fluampicil 266: 262: 252: 245: 237: 233: 229: 228: 226: 217: 213: 206: 202: 199: 195: 194: 192: 190: 186: 179: 175: 174: 172: 170: 166: 159: 155: 152: 148: 147: 145: 143: 139: 134: 126: 121: 118: 117: 115: 113: 109: 106: 105:intramuscular 102: 98: 96: 90: 87:Clinical data 85: 82: 79: 77: 73: 70: 67: 65: 61: 56: 52: 47: 43: 38: 30: 19: 18:Co-fluampicil 1892:inhibitors ( 1882:inhibitors ( 1810:Lipopeptides 1801:Polypeptides 1711: 1700:Combinations 1631:Nocardicin A 1548:Ceftobiprole 1391:Cefoperazone 1249:Cefaloridine 1234:Cefaloglycin 1172:Carbacephems 1040:Piperacillin 869:Penamecillin 770:, a group of 683:. Retrieved 663: 656: 644:. Retrieved 636:patient.info 635: 609:. Retrieved 605: 577:. Retrieved 573:the original 566: 529: 485: 456:Co-amoxiclav 445: 437: 421: 418:Interactions 397: 385: 378: 369: 331: 328: 325:Formulations 304: 296: 279: 268: 260: 259: 248:   29: 2006:Penicillins 1964:from market 1943:Teixobactin 1921:Tyrothricin 1890:bactoprenol 1884:Cycloserine 1690:Vaborbactam 1680:Durlobactam 1608:Monobactams 1566:Cefiderocol 1558:Siderophore 1543:Ceftolozane 1457:Cefpimizole 1427:Cefpodoxime 1422:Cefpiramide 1417:Cefmenoxime 1412:Ceftizoxime 1407:Cefdaloxime 1386:Ceftazidime 1375:Ceftriaxone 1347:Carbacephem 1341:Cefmetazole 1297:Cefamandole 1259:Cefatrizine 1239:Cefacetrile 1224:Cefroxadine 1168:Cephamycins 1094:Carbapenems 1050:Mezlocillin 1007:Ticarcillin 948:Amoxicillin 914:Methicillin 889:Cloxacillin 859:Azidocillin 849:Propicillin 794:Penicillins 646:18 December 611:18 December 579:18 December 428:allopurinol 334:intravenous 136:Identifiers 101:intravenous 1995:Categories 1931:Tyrocidine 1926:Gramicidin 1894:Bacitracin 1870:Fosfomycin 1841:Ramoplanin 1819:Daptomycin 1685:Relebactam 1658:Tazobactam 1589:Cefquinome 1576:Veterinary 1520:Cefquinome 1510:Cefozopran 1472:Ceftiolene 1462:Cefsulodin 1452:Cefodizime 1437:Cefditoren 1432:Ceftibuten 1380:Cefotaxime 1351:Loracarbef 1317:Cephamycin 1307:Ceforanide 1287:Cefuroxime 1244:Cefalonium 1214:Cefazaflur 1209:Cefazedone 1199:Cefadroxil 1066:Mecillinam 1045:Azlocillin 1021:Temocillin 962:Hetacillin 953:Ampicillin 685:2020-12-18 563:"Magnapen" 462:References 388:penicillin 301:Indication 288:ampicillin 205:43B2M34G2V 198:7C782967RD 169:ChemSpider 142:CAS Number 64:Ampicillin 1974:Phase III 1962:Withdrawn 1938:Isoniazid 1824:Surfactin 1675:Avibactam 1653:Sulbactam 1626:Carumonam 1621:Tigemonam 1616:Aztreonam 1594:Cefovecin 1584:Ceftiofur 1515:Cefpirome 1486:Latamoxef 1477:Oxacephem 1447:Cefetamet 1402:Cefcapene 1326:Cefotetan 1321:Cefoxitin 1312:Cefuzonam 1302:Cefonicid 1282:Cefprozil 1254:Cefalotin 1229:Ceftezole 1219:Cefradine 1204:Cefapirin 1194:Cefalexin 1189:Cefazolin 1149:Ritipenem 1144:Faropenem 1137:Panipenem 1126:Meropenem 1116:Doripenem 1107:Ertapenem 988:Epicillin 909:Nafcillin 904:Oxacillin 752:β-lactams 731:cell wall 606:Drugs.com 393:porphyria 277:tradename 158:5250-39-5 93:Routes of 1914:lysozyme 1860:Inhibit 1505:Cefepime 1481:Flomoxef 1467:Cefteram 1442:Cefotiam 1397:Cefdinir 1370:Cefixime 1331:Cefminox 1277:Cefaclor 1142:Penems ( 1132:Biapenem 1121:Imipenem 930:spectrum 928:Extended 810:spectrum 780:-alanine 776:-alanyl- 735:envelope 679:Archived 640:Archived 450:See also 280:Magnapen 251:(verify) 178:21106281 112:ATC code 1160:Cephems 442:History 151:69-53-4 128:) 122: ( 120:J01CR50 1957:WHO-EM 1664:Clavam 1098:Penems 808:Narrow 798:Penams 671:  538:  492:  366:Dosage 99:Oral, 1904:Other 1876:DADAL 1833:Other 1649:Penam 1059:Other 768:PBPs 743:J01D 739:J01C 733:and 669:ISBN 648:2020 613:2020 581:2020 536:ISBN 490:ISBN 290:and 265:INNs 189:UNII 1866:NAM 426:or 410:or 311:ear 273:BAN 221:EPA 125:WHO 1997:: 1970:: 1880:AR 1862:PG 1096:/ 1014:/ 677:. 638:. 634:. 621:^ 604:. 589:^ 565:. 550:^ 504:^ 470:^ 406:, 402:, 395:. 317:, 309:, 286:, 103:, 1896:) 1886:) 1878:/ 1872:) 1723:) 1719:( 1692:) 1670:) 1666:( 1660:) 1651:( 1488:) 1479:( 1393:) 1353:) 1349:( 1343:) 1319:( 1151:) 1139:) 1128:) 1114:( 1072:) 1068:( 984:) 955:( 900:) 891:( 800:) 796:( 784:) 778:D 774:D 745:) 741:- 737:( 719:e 712:t 705:v 688:. 650:. 615:. 583:. 544:. 498:. 271:( 263:( 223:) 219:( 20:)

Index

Co-fluampicil


Ampicillin
β-lactam antibiotic (penicillin)
Flucloxacillin
β-lactam antibiotic (penicillin)
Routes of
administration

intravenous
intramuscular
ATC code
J01CR50
WHO
CAS Number
69-53-4
5250-39-5
ChemSpider
21106281
UNII
7C782967RD
43B2M34G2V
CompTox Dashboard
DTXSID90894834
Edit this at Wikidata
(verify)
INNs
BAN
tradename
β-lactam antibiotics
ampicillin

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