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level. His work in this area has involved using a combination of both computational/theoretical models coupled with biochemical experiments, which are designed to test and refine these models. Most notably, Stultz’ research group has developed methods for analyzing and modeling intrinsically disordered proteins (IDPs) that are involved in neurodegenerative disorders. In the mid 2010s, he and his coworkers developed a novel method for modeling IDPs that uses
Bayesian statistics to quantify the uncertainty in the underlying structural ensemble. Stultz and his lab have also developed a variational Bayes’ method that enables them to apply these methods to larger systems in a fraction of the CPU time that would be required using a standard Bayes’ formalism.
191:. He then joined MIT in 2003 as a Postdoctoral Fellow and became an Assistant Professor in 2004. He was subsequently, appointed the Keck Associate Professor of Biomedical Engineering in 2007. In 2014, Stultz became Full Professor. Stultz was also appointed to the Committee on Higher Degrees in Biopyshics at Harvard University in 2004 and joined the cardiology staff at the Massachusetts General Hospital in 2017.
136:. He is the Nina T. and Robert H. Rubin Professor in Medical Engineering and Science at MIT, a Professor of Electrical Engineering and Computer Science also at MIT, a faculty member in the Harvard-MIT Division of Health Sciences and Technology, and a cardiologist at the Massachusetts General Hospital. He is also co-Director of the
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Stultz's research is focused on understanding the behavior of biomolecules that are involved in common human diseases; on development of machine learning models to identify high risk patients; and on the development of optimal treatment strategies for high risk patients. His work involves the use of
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Stultz began his career in computational biophysics, modeling the structure and function of flexible proteins that play a role in a number of common human diseases. His early research focused on building and applying computational tools to improve understanding of disease processes at the molecular
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In recent years, work in Stultz’s group has shifted to the application of signal processing and machine learning tools to help identify patients at elevated risk of cardiovascular death after an acute coronary syndrome. Stultz and collaborators have developed several ECG-based metrics that help in
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that are involved in common human diseases; on development of machine learning models to identify high risk patients; and on the development of optimal treatment strategies for high risk patients. His work involves the use of computational modeling and machine learning. He is a past recipient of a
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Stultz has received several honors in recognition of his work. These include a James
Tolbert Shipley Prize from Harvard Medical School, a Burroughs Wellcome Fund Career Award (2003), the Irving London Teaching Award (2006), the W. M. Keck Career Development Professorship in Biomedical Engineering
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Syed Z., Stultz CM., Scirica BM., Guttag JV. Computationally
Generated Cardiac Biomarkers for Risk Stratification Following Acute Coronary Syndrome. Science: Translational Medicine 28 September Vol 3 Issue 102 102ra95,
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Gurry, T., Ullman, O., Fisher, C. K., Perovic, I., Pochapsky, T., & Stultz, C. M. (2013). The
Dynamic Structure of α-Synuclein Multimers. Journal of the American Chemical Society, 135(10), 3865–3872.
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Ziegler, Z.; Schmidt, M.; Gurry, T.; Burger, V.; Stultz, C. M. (2016). "Mollack: a web server for the automated creation of conformational ensembles for intrinsically disordered proteins".
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Stultz joined
Harvard Medical School as a Clinical Fellow in 1997, becoming a Research Fellow in 2000. At the same time, he also worked as an Intern, Resident and Cardiology Fellow at the
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Fisher, C. K., Huang, A., & Stultz, C. M. (2010). Modeling
Intrinsically Disordered Proteins with Bayesian Statistics. Journal of the American Chemical Society, 132(42), 14919–14927.
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Stultz, C. M., Nambudripad, R., Lathrop, R. H., & White, J. V. (1997). Predicting
Protein Structure With Probabilistic Models. Advances in Molecular and Cell Biology, 447–506.
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from MIT (2007), a Career Award from the
National Science Foundation (2008), a Renée Finn Faculty Research Innovation Fellowship (2014). He was inducted into the
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Myers PD., Huang W., Anderson F., Stultz SM. (2017) Choosing
Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome, Scientific Reports 7 , 1–12
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Fisher, C. K., & Stultz, C. M. (2011). Constructing ensembles for intrinsically disordered proteins. Current
Opinion in Structural Biology, 21(3), 426–431.
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Stultz, C. M. (2002). Localized Unfolding of Collagen Explains Collagenase Cleavage Near Imino-poor Sites. Journal of Molecular Biology, 319(5), 997–1003.
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Stultz CM. The Advent of Clinically Useful Deep Learning. Journal of the American College of Cardiology, Electrophysiology (2019), vol. 5 no. 5 587-589
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205:, highlighting the software he and co-workers developed, which uses electrocardiographic data to identify patients at high risk for a heart attack.
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In addition to his academic appointments, Stultz is a member of the Research Laboratory of Electronics (RLE), and an associate member of the
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Stultz, C. M., White, J. V., & Smith, T. F. (2008). Structural analysis based on state-space modeling. Protein Science, 2(3), 305–314.
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Stultz, C. M.; Karplus, M. (2000). "Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin".
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and a Ph.D. in Biophysics from Harvard University, both in 1997. His Ph.D. thesis work was done in the laboratory of Nobelist
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College of Fellows. for "ground-breaking contributions to the understanding of protein function in health and disease".
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survivor in the immediate aftermath of the attack are described in the 2017 book Perfect Strangers.
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identifying patients at elevated risk of cardiovascular death after an acute coronary syndrome.
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198:(CSAIL) at MIT. He currently leads the Computational Cardiovascular Research Group at MIT.
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10.1002/(SICI)1097-0134(20000801)40:2<258::AID-PROT80>3.0.CO;2-I
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Stultz received his A.B. magna cum laude in Mathematics and Philosophy from
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10.1002/(SICI)1097-0134(19991201)37:4<512::AID-PROT3>3.0.CO;2-O
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416:"HST Faculty Member Collin Stultz Discusses the Breadth of his Research"
686:"Intrinsically disordered proteins: where computation meets experiment"
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475:"The Human Face of Big Data: an unlikely subject for a great book"
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in 1988. He then went on to receive a M.D. magna cum laude from
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Burger, Virginia M.; Gurry, Thomas; Stultz, Collin M. (2014).
602:"Constructing ensembles for intrinsically disordered proteins"
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Stultz's research is focused on understanding the behavior of
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American Institute for Medical and Biological Engineering
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American Institute for Medical and Biological Engineering
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Computer Science and Artificial Intelligence Laboratory
784:"Collin Stultz AIMBE College of Fellows Class of 2020"
374:"Collin Stultz AIMBE College of Fellows Class of 2020"
360:"CAREER: The Structure of Collagen and Collagenolysis"
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Harvard–MIT Program in Health Sciences and Technology
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518:"MCSS functionality maps for a flexible protein"
728:"5 ways big data is transforming everyday life"
221:computational modeling and machine learning.
208:Shores Salter and Stultz’s efforts to help a
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346:"2009 Burroughs Wellcome Fund Annual Report"
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461:"RResearch Laboratory of Electronics"
201:Stultz was featured in the 2012 book
130:Massachusetts Institute of Technology
106:Massachusetts Institute of Technology
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447:"Research Laboratory of Electronics"
742:"Big Data Gets Its Own Photo Album"
516:Stultz, C. M.; Karplus, M. (1999).
489:"When love is stronger than a bomb"
151:in the Biomedical Sciences, and a
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803:MIT School of Engineering faculty
756:"Irving M. London Teaching Award"
503:"Collin Stultz - Google Scholar"
333:"Collin M. Stultz, M.D., Ph.D."
189:Brigham & Women's Hospital
134:Massachusetts General Hospital
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813:Harvard Medical School alumni
663:10.1093/bioinformatics/btw200
155:. He is also a member of the
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203:The Human Face of Big Data
618:10.1016/j.sbi.2011.04.001
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388:"Collin Stultz, MD, PhD"
149:Burroughs Wellcome Award
430:"Collin M. Stultz - CV"
210:Boston Marathon bombing
808:Harvard College alumni
173:Harvard Medical School
87:Harvard Medical School
246:Selected publications
122:biomolecular engineer
744:. 13 September 2012.
703:10.3390/polym6102684
233:Societies and awards
159:College of Fellows.
128:and academic at the
126:physician-scientist
64:Academic background
818:American engineers
402:"Collin M. Stultz"
83:Harvard University
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690:Polymers
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