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The signs and symptoms of CDA type III tend to be milder than those of the other types. Most affected individuals do not have hepatosplenomegaly, and iron does not build up in tissues and organs. In adulthood, abnormalities of a specialized tissue at the back of the eye (the retina) can cause vision
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CDA type III is transmitted autosomal dominantly. The genetic cause of CDA type III is known to be a problem with the KIF23 gene, located on the long arm of chromosome 15 at a position designated 15q22.
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impairment. Some people with CDA type III also have a blood disorder known as monoclonal gammopathy, which can lead to a cancer of white blood cells (multiple myeloma).
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Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21-q25
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70:. New evidence suggests that this may be passed on recessively as well.
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49:Congenital dyserythropoietic anemia type III
22:Congenital dyserythropoietic anemia type III
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262:Congenital dyserythropoietic anemia
246:congenital dyserythropoietic anemia
201:Congenital dyserythropoietic anemia
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175:Treatment consists of frequent
216:List of hematologic conditions
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266:National Institutes of Health
185:bone marrow transplantation
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183:. Potential cures include
248:- Genetic Home References
59:, bone marrow erythroid
268:Home Genetic Reference
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177:blood transfusions
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181:chelation therapy
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16:Medical condition
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211:Hemoglobinopathy
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206:Thalassemia
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264:at the US
222:References
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171:Treatment
132:Diagnosis
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343:Category
195:See also
83:Genetics
349:Anemias
302:: D64.4
53:CDA III
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125:15q21
114:105600
110:CDAN3
105:Locus
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120:KIF23
102:Gene
94:Type
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311:9-CM
187:and
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307:ICD
295:ICD
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