242:
219:
116:
141:
500:
493:
248:
147:
1883:
997:
This gene encodes a protein found in corneodesmosomes, which localize to the human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for
1271:
Lundström A, Serre G, Haftek M, Egelrud T (1995). "Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation".
1014:
1311:"Expression cloning of human corneodesmosin proves its identity with the product of the S gene and allows improved characterization of its processing during keratinocyte differentiation"
255:
154:
1600:
Levy-Nissenbaum E, Betz RC, Frydman M, et al. (2003). "Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin".
713:
1709:"A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups"
77:
694:
1114:"Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes"
1832:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1421:"Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation"
1952:
1094:
1928:
1076:
1947:
241:
1489:
Hui J, Oka A, Tamiya G, et al. (2003). "Corneodesmosin DNA polymorphisms in MHC haplotypes and
Japanese patients with psoriasis".
928:
921:
218:
1518:
Orrù S, Giuressi E, Casula M, et al. (2003). "Psoriasis is associated with a SNP haplotype of the corneodesmosin gene (CDSN)".
1785:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1390:
Guerrin M, Vincent C, Simon M, et al. (2001). "Identification of six novel polymorphisms in the human corneodesmosin gene".
1215:
1063:
1042:
1346:"Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris"
1234:
Toribio J, Quiñones PA (1975). "Hereditary hypotrichosis simplex of the scalp. Evidence for autosomal dominant inheritance".
1059:
1674:"Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7"
140:
115:
1345:
1038:
57:
254:
153:
1921:
247:
146:
758:
65:
739:
1456:"Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties"
1744:"Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice"
1914:
1794:
1560:
1166:
129:
1002:. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
44:
1155:"Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation"
904:
900:
853:
849:
1818:
1625:
1297:
1259:
89:
1639:"Homo-oligomerization of human corneodesmosin is mediated by its N-terminal glycine loop domain"
1549:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
879:
828:
1861:
1810:
1773:
1730:
1695:
1660:
1617:
1588:
1535:
1506:
1477:
1442:
1407:
1378:
1332:
1289:
1251:
1194:
1135:
37:
1898:
1957:
1851:
1843:
1802:
1763:
1755:
1720:
1685:
1650:
1609:
1578:
1568:
1527:
1498:
1467:
1432:
1399:
1368:
1360:
1322:
1281:
1243:
1184:
1174:
1125:
499:
334:
265:
209:
164:
492:
309:
85:
1403:
1798:
1564:
1170:
1856:
1831:
1247:
1768:
1743:
1583:
1548:
1531:
1502:
1364:
628:
623:
618:
613:
608:
603:
598:
593:
577:
572:
567:
562:
557:
541:
1941:
1690:
1673:
1655:
1638:
1189:
1154:
528:
1629:
1263:
69:
1894:
1822:
999:
327:
106:
1301:
93:
1099:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1081:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
226:
123:
73:
1327:
1310:
1130:
1113:
1179:
658:
470:
348:
293:
280:
192:
179:
81:
1865:
1814:
1777:
1734:
1699:
1664:
1621:
1592:
1573:
1539:
1510:
1481:
1472:
1455:
1446:
1437:
1420:
1411:
1382:
1336:
1293:
1255:
1198:
1139:
968:
1725:
1708:
1373:
952:
803:
784:
1806:
1759:
963:
1847:
1285:
984:
770:
725:
936:
680:
1882:
1613:
643:
639:
1890:
1112:
Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G (Jan 1998).
991:
61:
508:
1015:
List of conditions caused by problems with junctional proteins
1547:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
48:, D6S586E, HTSS, HTSS1, HYPT2, PSS, PSS1, corneodesmosin, S
317:
1902:
1454:
Jonca N, Guerrin M, Hadjiolova K, et al. (2002).
1830:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
482:
1672:
Caubet C, Jonca N, Brattsand M, et al. (2004).
1309:
Guerrin M, Simon M, Montézin M, et al. (1998).
1344:Jenisch S, Koch S, Henseler T, et al. (2000).
893:
872:
842:
821:
1055:
1053:
1051:
1034:
1032:
1030:
1419:Simon M, Jonca N, Guerrin M, et al. (2001).
264:
163:
1707:Capon F, Allen MH, Ameen M, et al. (2005).
1637:Caubet C, Jonca N, Lopez F, et al. (2004).
16:Protein-coding gene in the species Homo sapiens
1742:Yang T, Liang D, Koch PJ, et al. (2004).
1060:GRCm38: Ensembl release 89: ENSMUSG00000039518
1922:
8:
1039:GRCh38: Ensembl release 89: ENSG00000204539
1929:
1915:
654:
524:
305:
204:
101:
1855:
1767:
1724:
1689:
1654:
1582:
1572:
1471:
1436:
1372:
1326:
1188:
1178:
1129:
1210:
1208:
1026:
18:
269:
230:
225:
168:
127:
122:
7:
1879:
1877:
1404:10.1034/j.1399-0039.2001.057001032.x
624:negative regulation of cornification
1011:Hypertrichosis simplex of the scalp
1901:. You can help Knowledge (XXG) by
1248:10.1111/j.1365-2133.1974.tb12455.x
1216:"Entrez Gene: CDSN corneodesmosin"
890:
869:
839:
818:
794:
775:
749:
730:
704:
685:
487:
405:
343:
322:
14:
1532:10.1034/j.1399-0039.2002.600403.x
1503:10.1034/j.1399-0039.2002.600110.x
1365:10.1034/j.1399-0039.1999.540501.x
987:that in humans is encoded by the
542:protein homodimerization activity
1881:
1691:10.1111/j.0022-202X.2004.22512.x
1656:10.1111/j.0022-202X.2004.22331.x
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1153:Zhou Y, Chaplin DD (Nov 1993).
509:More reference expression data
471:More reference expression data
1:
1953:Human chromosome 6 gene stubs
238:
137:
1553:Proc. Natl. Acad. Sci. U.S.A
604:keratinocyte differentiation
1948:Genes on human chromosome 6
445:subcutaneous adipose tissue
1974:
1876:
437:superior surface of tongue
1095:"Mouse PubMed Reference:"
1077:"Human PubMed Reference:"
967:
962:
958:
951:
935:
916:
897:
876:
865:
846:
825:
814:
801:
797:
782:
778:
769:
756:
752:
737:
733:
724:
711:
707:
692:
688:
679:
664:
657:
653:
637:
527:
523:
506:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1328:10.1074/jbc.273.35.22640
1159:Proc Natl Acad Sci U S A
1131:10.1074/jbc.272.50.31770
929:Chr 17: 35.86 – 35.87 Mb
1180:10.1073/pnas.90.20.9470
922:Chr 6: 31.12 – 31.12 Mb
619:corneocyte desquamation
1574:10.1073/pnas.242603899
1473:10.1074/jbc.M108438200
1438:10.1074/jbc.M100201200
383:skeletal muscle tissue
609:epidermis development
232:Chromosome 17 (mouse)
558:extracellular region
449:white adipose tissue
425:skin of external ear
375:gastrocnemius muscle
130:Chromosome 6 (human)
1807:10.1038/nature04209
1799:2005Natur.437.1173R
1760:10.1101/gad.1232104
1678:J. Invest. Dermatol
1643:J. Invest. Dermatol
1565:2002PNAS...9916899M
1274:Arch. Dermatol. Res
1171:1993PNAS...90.9470Z
1889:This article on a
1848:10.1101/gr.4039406
1726:10.1093/hmg/ddh273
1286:10.1007/BF00371795
759:ENSMUSG00000039518
629:cell-cell adhesion
599:skin morphogenesis
587:Biological process
573:cornified envelope
568:cell-cell junction
551:Cellular component
535:Molecular function
1910:
1909:
1559:(26): 16899–903.
978:
977:
974:
973:
947:
946:
912:
911:
887:
886:
861:
860:
836:
835:
810:
809:
791:
790:
765:
764:
746:
745:
720:
719:
701:
700:
649:
648:
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1965:
1931:
1924:
1917:
1885:
1878:
1869:
1859:
1826:
1793:(7062): 1173–8.
1781:
1771:
1738:
1728:
1703:
1693:
1668:
1658:
1633:
1596:
1586:
1576:
1543:
1514:
1485:
1475:
1450:
1440:
1415:
1386:
1376:
1350:
1340:
1330:
1305:
1267:
1220:
1219:
1212:
1203:
1202:
1192:
1182:
1150:
1144:
1143:
1133:
1109:
1103:
1102:
1091:
1085:
1084:
1073:
1067:
1057:
1046:
1036:
960:
959:
931:
924:
907:
891:
882:
870:
866:RefSeq (protein)
856:
840:
831:
819:
795:
776:
750:
731:
705:
686:
655:
525:
511:
502:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:CDSN - orthologs
47:
40:
19:
1973:
1972:
1968:
1967:
1966:
1964:
1963:
1962:
1938:
1937:
1936:
1935:
1874:
1872:
1829:
1784:
1741:
1713:Hum. Mol. Genet
1706:
1671:
1636:
1599:
1546:
1520:Tissue Antigens
1517:
1491:Tissue Antigens
1488:
1453:
1431:(23): 20292–9.
1418:
1392:Tissue Antigens
1389:
1353:Tissue Antigens
1348:
1343:
1321:(35): 22640–7.
1308:
1270:
1236:Br. J. Dermatol
1233:
1229:
1227:Further reading
1224:
1223:
1214:
1213:
1206:
1152:
1151:
1147:
1124:(50): 31770–6.
1111:
1110:
1106:
1093:
1092:
1088:
1075:
1074:
1070:
1058:
1049:
1037:
1028:
1023:
1008:
969:View/Edit Mouse
964:View/Edit Human
927:
920:
917:Location (UCSC)
903:
899:
878:
852:
848:
827:
740:ENSG00000204539
633:
582:
578:plasma membrane
546:
507:
497:
496:
469:
460:
455:
451:
447:
443:
441:skin of abdomen
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
359:skin of abdomen
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1971:
1969:
1961:
1960:
1955:
1950:
1940:
1939:
1934:
1933:
1926:
1919:
1911:
1908:
1907:
1886:
1871:
1870:
1827:
1782:
1754:(19): 2354–8.
1739:
1719:(20): 2361–8.
1704:
1684:(5): 1235–44.
1669:
1634:
1614:10.1038/ng1163
1597:
1544:
1515:
1486:
1451:
1416:
1387:
1341:
1306:
1268:
1230:
1228:
1225:
1222:
1221:
1204:
1165:(20): 9470–4.
1145:
1104:
1086:
1068:
1047:
1025:
1024:
1022:
1019:
1018:
1017:
1012:
1007:
1004:
981:Corneodesmosin
976:
975:
972:
971:
966:
956:
955:
949:
948:
945:
944:
942:
940:
933:
932:
925:
918:
914:
913:
910:
909:
895:
894:
888:
885:
884:
874:
873:
867:
863:
862:
859:
858:
844:
843:
837:
834:
833:
823:
822:
816:
812:
811:
808:
807:
799:
798:
792:
789:
788:
780:
779:
773:
767:
766:
763:
762:
754:
753:
747:
744:
743:
735:
734:
728:
722:
721:
718:
717:
709:
708:
702:
699:
698:
690:
689:
683:
677:
676:
671:
666:
662:
661:
651:
650:
647:
646:
635:
634:
632:
631:
626:
621:
616:
611:
606:
601:
596:
590:
588:
584:
583:
581:
580:
575:
570:
565:
560:
554:
552:
548:
547:
545:
544:
538:
536:
532:
531:
521:
520:
517:
516:
513:
512:
504:
503:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1970:
1959:
1956:
1954:
1951:
1949:
1946:
1945:
1943:
1932:
1927:
1925:
1920:
1918:
1913:
1912:
1906:
1904:
1900:
1896:
1892:
1887:
1884:
1880:
1875:
1867:
1863:
1858:
1853:
1849:
1845:
1841:
1837:
1833:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1783:
1779:
1775:
1770:
1765:
1761:
1757:
1753:
1749:
1745:
1740:
1736:
1732:
1727:
1722:
1718:
1714:
1710:
1705:
1701:
1697:
1692:
1687:
1683:
1679:
1675:
1670:
1666:
1662:
1657:
1652:
1649:(3): 747–54.
1648:
1644:
1640:
1635:
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1598:
1594:
1590:
1585:
1580:
1575:
1570:
1566:
1562:
1558:
1554:
1550:
1545:
1541:
1537:
1533:
1529:
1525:
1521:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1487:
1483:
1479:
1474:
1469:
1466:(7): 5024–9.
1465:
1461:
1460:J. Biol. Chem
1457:
1452:
1448:
1444:
1439:
1434:
1430:
1426:
1425:J. Biol. Chem
1422:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1388:
1384:
1380:
1375:
1374:2027.42/66173
1370:
1366:
1362:
1359:(5): 439–49.
1358:
1354:
1347:
1342:
1338:
1334:
1329:
1324:
1320:
1316:
1315:J. Biol. Chem
1312:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1280:(7): 369–75.
1279:
1275:
1269:
1265:
1261:
1257:
1253:
1249:
1245:
1242:(6): 687–96.
1241:
1237:
1232:
1231:
1226:
1217:
1211:
1209:
1205:
1200:
1196:
1191:
1186:
1181:
1176:
1172:
1168:
1164:
1160:
1156:
1149:
1146:
1141:
1137:
1132:
1127:
1123:
1119:
1115:
1108:
1105:
1100:
1096:
1090:
1087:
1082:
1078:
1072:
1069:
1065:
1061:
1056:
1054:
1052:
1048:
1044:
1040:
1035:
1033:
1031:
1027:
1020:
1016:
1013:
1010:
1009:
1005:
1003:
1001:
995:
993:
990:
986:
982:
970:
965:
961:
957:
954:
950:
943:
941:
938:
934:
930:
926:
923:
919:
915:
908:
906:
902:
896:
892:
889:
883:
881:
875:
871:
868:
864:
857:
855:
851:
845:
841:
838:
832:
830:
824:
820:
817:
815:RefSeq (mRNA)
813:
806:
805:
800:
796:
793:
787:
786:
781:
777:
774:
772:
768:
761:
760:
755:
751:
748:
742:
741:
736:
732:
729:
727:
723:
716:
715:
710:
706:
703:
697:
696:
691:
687:
684:
682:
678:
675:
672:
670:
667:
663:
660:
656:
652:
645:
641:
636:
630:
627:
625:
622:
620:
617:
615:
614:cornification
612:
610:
607:
605:
602:
600:
597:
595:
594:cell adhesion
592:
591:
589:
586:
585:
579:
576:
574:
571:
569:
566:
564:
561:
559:
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533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
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394:
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295:
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271:17|17 B1
267:
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63:
59:
51:
46:
39:
34:
29:
25:
20:
1903:expanding it
1895:chromosome 6
1888:
1873:
1842:(1): 55–65.
1839:
1835:
1790:
1786:
1751:
1747:
1716:
1712:
1681:
1677:
1646:
1642:
1608:(2): 151–3.
1605:
1601:
1556:
1552:
1526:(4): 292–8.
1523:
1519:
1497:(1): 77–83.
1494:
1490:
1463:
1459:
1428:
1424:
1395:
1391:
1356:
1352:
1318:
1314:
1277:
1273:
1239:
1235:
1162:
1158:
1148:
1121:
1117:
1107:
1098:
1089:
1080:
1071:
1000:desquamation
996:
988:
980:
979:
905:NP_001342204
901:NP_001008424
898:
877:
854:NM_001355275
850:NM_001008424
847:
826:
802:
783:
757:
738:
712:
693:
673:
668:
433:skin of back
333:
326:
53:External IDs
1398:(1): 32–8.
1118:J Biol Chem
391:gallbladder
363:skin of leg
292:35,868,077
279:35,863,025
191:31,120,446
178:31,115,087
31:Identifiers
1942:Categories
1836:Genome Res
1602:Nat. Genet
1066:, May 2017
1045:, May 2017
1021:References
337:(ortholog)
74:HomoloGene
1893:on human
1748:Genes Dev
880:NP_001255
829:NM_001264
659:Orthologs
563:desmosome
429:esophagus
82:GeneCards
1866:16344560
1815:16189514
1778:15466487
1735:15333584
1700:15140227
1665:15086562
1630:10116539
1622:12754508
1593:12477932
1540:12472658
1511:12366786
1482:11739386
1447:11279026
1412:11169256
1383:10599883
1264:28843515
1062:–
1041:–
1006:See also
953:Wikidata
638:Sources:
457:gastrula
395:duodenum
371:placenta
367:testicle
1958:Plakins
1857:1356129
1823:4427026
1795:Bibcode
1561:Bibcode
1337:9712893
1294:7818278
1256:4141628
1199:8415725
1167:Bibcode
1140:9395522
1064:Ensembl
1043:Ensembl
985:protein
771:UniProt
726:Ensembl
665:Species
644:QuickGO
312:pattern
170:6p21.33
70:3505689
38:Aliases
1864:
1854:
1821:
1813:
1787:Nature
1776:
1769:522985
1766:
1733:
1698:
1663:
1628:
1620:
1591:
1584:139241
1581:
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1335:
1302:614870
1300:
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1197:
1187:
1138:
939:search
937:PubMed
804:Q7TPC1
785:Q15517
714:386463
681:Entrez
483:BioGPS
453:cervix
387:tonsil
379:vagina
62:602593
1897:is a
1819:S2CID
1626:S2CID
1349:(PDF)
1298:S2CID
1260:S2CID
1190:47590
983:is a
674:Mouse
669:Human
640:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:48005
1899:stub
1891:gene
1862:PMID
1811:PMID
1774:PMID
1731:PMID
1696:PMID
1661:PMID
1618:PMID
1589:PMID
1536:PMID
1507:PMID
1478:PMID
1443:PMID
1408:PMID
1379:PMID
1333:PMID
1290:PMID
1252:PMID
1195:PMID
1136:PMID
992:gene
989:CDSN
695:1041
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:CDSN
58:OMIM
45:CDSN
22:CDSN
1852:PMC
1844:doi
1803:doi
1791:437
1764:PMC
1756:doi
1721:doi
1686:doi
1682:122
1651:doi
1647:122
1610:doi
1579:PMC
1569:doi
1528:doi
1499:doi
1468:doi
1464:277
1433:doi
1429:276
1400:doi
1369:hdl
1361:doi
1323:doi
1319:273
1282:doi
1278:286
1244:doi
1185:PMC
1175:doi
1126:doi
1122:272
421:lip
288:End
187:End
90:OMA
66:MGI
1944::
1860:.
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1238:.
1207:^
1193:.
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1163:90
1161:.
1157:.
1134:.
1120:.
1116:.
1097:.
1079:.
1050:^
1029:^
994:.
642:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
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76::
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60::
1930:e
1923:t
1916:v
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92::
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