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285:(a drug with specific anti-aura action, but no efficacy in migraine in general) has a marked suppressive effect which correlates with its rather selective action on the migraine aura. Valproate and riboflavin were shown to have no effect on the triggering of cortical spreading depression though they are effective in migraine without aura. Taken together, these results are compatible with a causal role of cortical spreading depression in migraine with aura, but not in migraine without aura.
943:
Sánchez-Porras, Renán; Santos, Edgar; Schöll, Michael; Stock, Christian; Zheng, Zelong; Schiebel, Patrick; Orakcioglu, Berk; Unterberg, Andreas W.; Sakowitz, Oliver W. (2014-09-01). "The effect of ketamine on optical and electrical characteristics of spreading depolarizations in gyrencephalic swine
296:
is capable of irregular and complex CSD propagation patterns. The irregularities of the folded cortex and the vasculature promote the presence of re-entrance waves, such as spirals and reverberating waves. The expansion of the wave then is less predictable and it is affected by the concentration of
104:
occlusion in IOS. The video has a speed of 50x to better appreciate the SDs through human eye. Pictures are dynamically subtracted to a reference picture 40 s before. First we see the initial area of change at the exact moment where the left MCAs are occluded. The area is highlighted with a white
20:
165:
Although the terms cortical spreading depression and spreading depolarization are often used as synonyms, a study found spreading depolarizations can produce variable effects on cortical activity in humans and rats, ranging from depressed to booming activity depending on SD depth.
1046:
Kentar, Modar; Mann, Martina; Sahm, Felix; Olivares-Rivera, Arturo; Sanchez-Porras, Renan; Zerelles, Roland; Sakowitz, Oliver W.; Unterberg, Andreas W.; Santos, Edgar (2020-01-15). "Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine".
524:
Santos, Edgar; Schöll, Michael; Sánchez-Porras, Renán; Dahlem, Markus A.; Silos, Humberto; Unterberg, Andreas; Dickhaus, Hartmut; Sakowitz, Oliver W. (2014-10-01). "Radial, spiral and reverberating waves of spreading depolarization occur in the gyrencephalic brain".
131:
hyperactivity followed by a wave of inhibition. Spreading depolarization describes a phenomenon characterized by the appearance of depolarization waves of the neurons and neuroglia that propagates across the
660:
Santos, Edgar; Sánchez-Porras, Renán; Dohmen, Christian; Hertle, Daniel; Unterberg, Andreas W.; Sakowitz, Oliver W. (2012-04-01). "Spreading depolarizations in a case of migraine-related stroke".
711:
Nasretdinov, Azat; Vinokurova, Daria; Lemale, Coline L.; Burkhanova-Zakirova, Gulshat; Chernova, Ksenia; Makarova, Julia; Herreras, Oscar; Dreier, Jens P.; Khazipov, Roustem (25 November 2023).
1105:. 29 April 2007, Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M., Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York.
1112:. 21 November 2003, Netsiri C, Bradley DP, Takeda T, Smith MI, Papadakis N, Hall LD, Parsons AA, James MF, Huang CL., Physiological Laboratory, University of Cambridge, Cambridge, UK.
1108:"A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA)",
1137:
The Co-Operative
Studies on Brain Injury Depolarizations is an international research consortium focused on the role of spreading depolarizations in acute neurologic injury
995:
Sánchez-Porras, R.; Zheng, Z.; Santos, E.; Schöll, M.; Unterberg, A. W.; Sakowitz, O. W. (2013-08-01). "The role of spreading depolarization in subarachnoid hemorrhage".
1209:
300:
Its triggers and propagation mechanisms, as well as clinical manifestations of CSD, are a therapeutic target to reduce brain damage after a stroke or brain lesion.
59:
768:
Brennan KC, Beltrán-Parrazal L, López-Valdés HE, Theriot J, Toga AW, Charles AC (2007). "Distinct vascular conduction with cortical spreading depression".
87:
466:"Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group"
90:
Cortical spreading depression seen using intrinsic optical signal imaging in gyrencephalic brain. Speed 50x. From Santos E et al. Neuroimage 2014.
576:
Porooshani H, Porooshani GH, Gannon L, Kyle GM (2004). "Speed of progression of migrainous visual aura measured by sequential field assessment".
162:, a particularly severe form of childhood epilepsy that appears to carry an unusually high risk of SUDEP (sudden unexpected death in epilepsy).
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1179:
147:, where CSD is assumed to ascend in well-nourished tissue and is typically benign in most cases, although it may increase the probability in
155:
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44:
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Bogdanov; et al. (Feb 2011). "Migraine preventive drugs differentially affect cortical spreading depression in rat".
74:
69:
281:) dose-dependently suppressed frequency of CSD induced by continuous cortical application of 1 M KCl solution. However
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309:
143:
conditions and facilitates neuronal death in energy-compromised tissue. CSD has also been implicated in migraine
254:
contribute to the initiation and propagation of cortical spreading depression, which is the underlying cause of
1144:
154:
Spreading depolarization within brainstem tissues regulating functions crucial for life has been implicated in
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Ayata; et al. (Apr 2006). "Suppression of cortical spreading depression in migraine prophylaxis".
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713:"Diversity of cortical activity changes beyond depression during Spreading Depolarizations"
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1115:"Cortical spreading depression (CSD): A neurophysiological correlate of migraine aura",
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352:"High-resolution in vivo imaging of the neurovascular unit during spreading depression"
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use the term cortical spreading depression to represent at least one of the following
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409:"Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature"
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Leão AAP (1944). "Spreading depression of activity in the cerebral cortex".
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1101:"Cortical spreading depression causes and coincides with tissue hypoxia",
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Chuquet, Julien; Hollender, Liad; Nimchinsky, Esther A. (2007-04-11).
1130:
1129:
18:
261:
Chronic daily administration of migraine prophylactic drugs (
158:, by way of ion channel mutations such as those seen in
105:
line. Later we appreciate the signal produced by SDs.
1134:
185:
The spreading of a self-propagating wave of cellular
611:Dreier, Jens P.; Reiffurth, Clemens (2015-05-20).
1178:Neurosciences Critical Care Unit, Cambridge, UK.
662:Cephalalgia: An International Journal of Headache
297:different molecules and gradients on the cortex.
519:
517:
1151:Dodick, David W.; J. Jay Gargus (August 2008).
613:"The stroke-migraine depolarization continuum"
239:phenomenon termed the spreading depression of
470:Journal of Cerebral Blood Flow and Metabolism
407:Ayata, Cenk; Lauritzen, Martin (2015-07-01).
60:ICHD classification and diagnosis of migraine
8:
1208:: CS1 maint: multiple names: authors list (
1159:. Scientific American Inc. pp. 56–63.
1119:, May 17, 2008, Richter F, Lehmenkühler A.
464:Hartings, Dreier; Jed, Jens (2017-05-01).
107:https://doi.org/10.1007/s00701-019-04132-8
26:
23:Animation of cortical spreading depression
1234:
1143:at the U.S. National Library of Medicine
744:
628:
497:
440:
383:
333:Dodick DW & Gargus JJ (August 2008).
95:
85:
326:
136:at a velocity of 1.5–9.5 mm/min.
1201:
7:
1180:"Spreading Cortical Depolarisation"
156:sudden unexpected death in epilepsy
100:Hemodynamic changes observed after
200:passing through an area of cortex.
14:
1219:"Professor Leão's original note"
1217:Péricles Maranhão Filho (2015).
1186:. NCCU Education. Archived from
958:10.1016/j.neuropharm.2014.04.018
539:10.1016/j.neuroimage.2014.05.021
235:in humans may be related to the
151:patients to develop a stroke.
847:Richter and Lehmenkühler (2008)
368:10.1523/JNEUROSCI.0721-07.2007
45:Prevention of migraine attacks
1:
1141:Spreading+Cortical+Depression
997:European Journal of Neurology
250:concentration and excitatory
113:Cortical spreading depression
55:Cortical spreading depression
630:10.1016/j.neuron.2015.04.004
75:Sporadic hemiplegic migraine
70:Familial hemiplegic migraine
590:10.1076/noph.28.2.101.23739
356:The Journal of Neuroscience
203:The spreading of a wave of
196:The spreading of a wave of
1288:
1061:10.1007/s00701-019-04132-8
771:Journal of Neurophysiology
737:10.1038/s41467-023-43509-3
425:10.1152/physrev.00027.2014
1236:10.1590/0004-282X20150087
1184:cambridgecriticalcare.net
914:10.1016/j.nbd.2010.10.014
310:Transient ischemic attack
1145:Medical Subject Headings
674:10.1177/0333102412441414
482:10.1177/0271678X16654496
246:Increased extracellular
211:and prolonged sustained
121:spreading depolarization
16:Type of evoked potential
827:10.1152/jn.1944.7.6.359
335:"Why migraines strike".
1272:Neurological disorders
1262:Cognitive neuroscience
1153:"Why Migraines Strike"
139:CSD can be induced by
109:
93:
24:
784:10.1152/jn.00028.2007
717:Nature Communications
413:Physiological Reviews
229:scintillating scotoma
99:
89:
22:
1223:Arq. Neuro-Psiquiatr
1049:Acta Neurochirurgica
129:electrophysiological
1157:Scientific American
729:2023NatCo..14.7729N
578:Neuro-Ophthalmology
338:Scientific American
1190:on 20 October 2014
1110:Magn Reson Imaging
110:
94:
25:
1009:10.1111/ene.12139
946:Neuropharmacology
871:10.1002/ana.20778
362:(15): 4036–4044.
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778:(6): 4143–4151.
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290:folded structure
237:neurophysiologic
213:vasoconstriction
205:vasoconstriction
170:Uses of the term
65:Retinal migraine
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191:cerebral cortex
175:Neuroscientists
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160:Dravet syndrome
127:) is a wave of
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902:Neurobiol. Dis
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815:J Neurophysiol
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1192:. Retrieved
1188:the original
1183:
1168:. Retrieved
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1103:Nat Neurosci
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209:vasodilation
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111:
54:
723:(1): 7729.
533:: 244–255.
283:lamotrigine
271:propranolol
181:processes:
1256:Categories
1229:(8): 729.
1194:20 October
1170:2008-08-16
1135:COSBID.org
1096:References
859:Ann Neurol
527:NeuroImage
263:topiramate
221:arterioles
217:contiguous
207:following
1267:Neurology
1165:0036-8733
1085:210196036
1069:0942-0940
1017:1468-1331
966:1873-7064
952:: 52–61.
944:cortex".
930:207065722
682:1468-2982
639:1097-4199
547:1095-9572
490:1559-7016
433:1522-1210
376:1529-2401
267:valproate
252:glutamate
219:cortical
1245:26222369
1204:cite web
1077:31940093
1033:23615512
1025:23551588
982:21562145
974:24796257
922:20977938
887:31232538
879:16450381
835:14270649
800:20878873
792:17329631
755:38007508
746:10676372
698:25190650
690:22407661
647:25996134
598:72813214
555:24852458
508:27317657
451:26133935
394:17428981
304:See also
233:migraine
198:ischemia
179:cortical
149:migraine
40:Migraine
31:Migraine
1117:Schmerz
725:Bibcode
563:1347927
499:5435289
442:4491545
385:6672520
292:of the
189:in the
141:hypoxic
1243:
1163:
1147:(MeSH)
1083:
1075:
1067:
1031:
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1015:
980:
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617:Neuron
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277:, and
134:cortex
1081:S2CID
1029:S2CID
978:S2CID
926:S2CID
883:S2CID
831:S2CID
796:S2CID
694:S2CID
594:S2CID
559:S2CID
321:Notes
119:) or
1241:PMID
1210:link
1196:2014
1161:ISSN
1073:PMID
1065:ISSN
1021:PMID
1013:ISSN
970:PMID
962:ISSN
918:PMID
875:PMID
788:PMID
751:PMID
686:PMID
678:ISSN
643:PMID
635:ISSN
551:PMID
543:ISSN
504:PMID
486:ISSN
447:PMID
429:ISSN
390:PMID
372:ISSN
288:The
241:Leão
227:The
145:aura
50:Aura
1231:doi
1057:doi
1053:162
1005:doi
954:doi
910:doi
867:doi
823:doi
780:doi
741:PMC
733:doi
670:doi
625:doi
586:doi
535:doi
494:PMC
478:doi
437:PMC
421:doi
380:PMC
364:doi
231:of
215:of
117:CSD
102:MCA
1258::
1239:.
1227:73
1225:.
1221:.
1206:}}
1202:{{
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621:86
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582:28
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549:.
541:.
531:99
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516:^
502:.
492:.
484:.
474:37
472:.
468:.
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435:.
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417:95
415:.
411:.
388:.
378:.
370:.
360:27
358:.
354:.
273:,
269:,
265:,
258:.
243:.
125:SD
1247:.
1233::
1212:)
1198:.
1173:.
1087:.
1059::
1035:.
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