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Cerebral cortex

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1924: 2343: 1261: 2331: 2355: 604: 1755: 73: 53: 1148: 1406: 1474: 650: 1095: 612: 1137:. The anterior cerebral artery supplies the anterior portions of the brain, including most of the frontal lobe. The middle cerebral artery supplies the parietal lobes, temporal lobes, and parts of the occipital lobes. The middle cerebral artery splits into two branches to supply the left and right hemisphere, where they branch further. The posterior cerebral artery supplies the occipital lobes. 2013: 1632:, for example, which serves critical functions such as regulation of heart and respiration rates, many areas of the cerebral cortex are not strictly necessary for survival. Thus, the evolution of the cerebral cortex has seen the advent and modification of new functional areas—particularly association areas that do not directly receive input from outside the cortex. 411: 1672: 673: 1449:. These cells will form the deep layers of the mature cortex, layers five and six. Later born neurons migrate radially into the cortical plate past the deep layer neurons, and become the upper layers (two to four). Thus, the layers of the cortex are created in an inside-out order. The only exception to this inside-out sequence of 2315:. Mushroom bodies are structures in the brains of many types of worms and arthropods that are known to play important roles in learning and memory; the genetic evidence indicates a common evolutionary origin, and therefore indicates that the origins of the earliest precursors of the cerebral cortex date back to the 574:(MRI) makes it possible to get a measure for the thickness of the human cerebral cortex and relate it to other measures. The thickness of different cortical areas varies but in general, sensory cortex is thinner than motor cortex. One study has found some positive association between the cortical thickness and 1883:(or nuclei). The basal ganglia receive input from the substantia nigra of the midbrain and motor areas of the cerebral cortex, and send signals back to both of these locations. They are involved in motor control. They are found lateral to the thalamus. The main components of the basal ganglia are the 586:
patients, though it is not known if this is the result of migraine attacks, the cause of them or if both are the result of a shared cause. A later study using a larger patient population reports no change in the cortical thickness in patients with migraine. A genetic disorder of the cerebral cortex,
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over the brain cortex. Pictures are dynamically subtracted to a reference picture 40 s before. First we see the initial area of change at the exact moment where the middle cerebral artery group (left) is occluded. The area is highlighted with a white line. Later we appreciate the signal produced by
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showed that the functional properties of the cortex change abruptly between laterally adjacent points; however, they are continuous in the direction perpendicular to the surface. Later works have provided evidence of the presence of functionally distinct cortical columns in the visual cortex (Hubel
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to the thalamus, establishing a very precise reciprocal interconnection between the cortex and the thalamus. That is, layer VI neurons from one cortical column connect with thalamus neurons that provide input to the same cortical column. These connections are both excitatory and inhibitory. Neurons
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Bhagwandin, Adhil; Molnár, Zoltán; Bertelsen, Mads F.; Karlsson, Karl Æ.; Alagaili, Abdulaziz N.; Bennett, Nigel C.; Hof, Patrick R.; Kaswera‐Kyamakya, Consolate; Gilissen, Emmanuel; Jayakumar, Jaikishan; Manger, Paul R. (2024). "Where Do Core Thalamocortical Axons Terminate in Mammalian Neocortex
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or prefrontal association complex is involved in planning actions and movement, as well as abstract thought. Globally, the association areas are organized as distributed networks. Each network connects areas distributed across widely spaced regions of the cortex. Distinct networks are positioned
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The motor areas are located in both hemispheres of the cortex. The motor areas are very closely related to the control of voluntary movements, especially fine fragmented movements performed by the hand. The right half of the motor area controls the left side of the body, and vice versa.
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Smigiel, R; Cabala, M; Jakubiak, A; Kodera, H; Sasiadek, MJ; Matsumoto, N; Sasiadek, MM; Saitsu, H (April 2016). "Novel COL4A1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection".
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Kentar, Modar; Mann, Martina; Sahm, Felix; Olivares-Rivera, Arturo; Sanchez-Porras, Renan; Zerelles, Roland; Sakowitz, Oliver W.; Unterberg, Andreas W.; Santos, Edgar (15 January 2020). "Detection of spreading depolarizations in a middle cerebral artery occlusion model in swine".
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shift in the cortical region occurs. This ultimately causes an expansion of the rostral regions. Therefore, Fgf8 and other FGFs play a role in the regulation of expression of Emx2 and Pax6 and represent how the cerebral cortex can become specialized for different functions.
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from thalamus type C neurons (core-type) as well as intra-hemispheric corticocortical afferents. The layers above layer IV are also referred to as supragranular layers (layers I-III), whereas the layers below are referred to as infragranular layers (layers V and VI).
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interactions in the cerebral cortex involved in associative learning and attention. While it was once thought that the input to layer I came from the cortex itself, it is now realized that layer I across the cerebral cortex mantle receives substantial input from
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and SchĂŒz (1998) claim that in primary sensory areas, at the cortical level where the input fibers terminate, up to 20% of the synapses are supplied by extracortical afferents but that in other areas and other layers the percentage is likely to be much lower.
699:. Each cortical layer has a characteristic distribution of different neurons and their connections with other cortical and subcortical regions. There are direct connections between different cortical areas and indirect connections via the thalamus. 2260:. The basic form of the pallium is a cylindrical layer enclosing fluid-filled ventricles. Around the circumference of the cylinder are four zones, the dorsal pallium, medial pallium, ventral pallium, and lateral pallium, which are thought to be 1293:
in order to give a fine distinction between the different cortical layers. Laminar differentiation is not fully complete until after birth since during development laminar neurons are still sensitive to extrinsic signals and environmental cues.
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Depicted in blue, Emx2 is highly expressed at the caudomedial pole and dissipates outward. Pax6 expression is represented in purple and is highly expressed at the rostral lateral pole. (Adapted from Sanes, D., Reh, T., & Harris, W. (2012).
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Functional columns were first defined in the cortex by Mountcastle (1957), who proposed the columnar hypothesis, which states that the cortex is composed of discrete, modular columns of neurons, characterized by a consistent connectivity
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The cortical layers are not simply stacked one over the other; there exist characteristic connections between different layers and neuronal types, which span all the thickness of the cortex. These cortical microcircuits are grouped into
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adjacent to one another yielding a complex series of interwoven networks. The specific organization of the association networks is debated with evidence for interactions, hierarchical relationships, and competition between networks.
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of superficial layers. This differential cell fate creates an inside-out topography in the cortex with younger neurons in superficial layers and older neurons in deeper layers. In addition, laminar neurons are stopped in
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are excitatory during development. This excitation is primarily driven by the flux of chloride ions through the GABA receptor, however in adults chloride concentrations shift causing an inward flux of chloride that
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present on the cortical neuron's cell body, and the axon is undeveloped. During the first year of life the dendrites become dramatically increased in number, such that they can accommodate up to a hundred thousand
982:. Cortical areas that have only a rudimentary layer IV are called dysgranular. Information processing within each layer is determined by different temporal dynamics with that in layers II/III having a slow 2  487:
cortex has a total surface area of about 0.12 square metres (1.3 sq ft). The folding is inward away from the surface of the brain, and is also present on the medial surface of each hemisphere within the
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in Pax6 can cause expression levels of Emx2 to expand out of its normal expression domain, which would ultimately lead to an expansion of the areas normally derived from the caudal medial cortex, such as the
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Meyer, Gundela; Goffinet, AndrĂ© M.; FairĂ©n, Alfonso (1999). "Feature Article: What is a Cajal–Retzius cell? A Reassessment of a Classical Cell Type Based on Recent Observations in the Developing Neocortex".
1276:. Similarly, the process of neurogenesis regulates lamination to form the different layers of the cortex. During this process there is an increase in the restriction of cell fate that begins with earlier 736:
cross-sections of the cortex to reveal the position of neuronal cell bodies and the intracortical axon tracts allowed neuroanatomists in the early 20th century to produce a detailed description of the
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Stahl, Ronny; Walcher, Tessa; De Juan Romero, Camino; Pilz, Gregor Alexander; Cappello, Silvia; Irmler, Martin; Sanz-Aquela, José Miguel; Beckers, Johannes; Blum, Robert (25 April 2013).
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directly onto the exposed brain in order to localise the functions of specific areas of the cortex. It is used in clinical and therapeutic applications including pre-surgical mapping.
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The neocortex is also known as the isocortex or neopallium and is the part of the mature cerebral cortex with six distinct layers. Examples of neocortical areas include the granular
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Of all the different brain regions, the cerebral cortex shows the largest evolutionary variation and has evolved most recently. In contrast to the highly conserved circuitry of the
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early in embryonic development. These signals regulate the size, shape, and position of cortical areas on the surface of the cortical primordium, in part by regulating gradients of
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is elongated, in what is seen as selective cell-cycle lengthening, the newly born neurons migrate to more superficial layers of the cortex. The migrating daughter cells become the
1923: 566:, have a neocortical thickness of about 0.5 mm; the ones with the largest brains, such as humans and fin whales, have thicknesses of 2–4 mm. There is an approximately 492:. Most mammals have a cerebral cortex that is convoluted with the peaks known as gyri and the troughs or grooves known as sulci. Some small mammals including some small 1782:. For example, the right primary somatosensory cortex receives information from the left limbs, and the right visual cortex receives information from the left visual 5565:"Preoperative multimodal motor mapping: a comparison of magnetoencephalography imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation" 2330: 343:, the majority of the cerebral cortex is not visible from the outside, but buried in the sulci. The major sulci and gyri mark the divisions of the cerebrum into the 1978:, for language reception. However, the processes of language expression and reception have been shown to occur in areas other than just those structures around the 5741: 308:. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the 3083:
Katherine L. Narr; Roger P. Woods; Paul M. Thompson; Philip Szeszko; Dilbert Robinson; Teodora Dimtcheva; Mala Gurbani; Arthur W. Toga; Robert M. Bilder (2007).
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next to the cortex could contribute to the regional expression of these transcription factors. Two very well studied patterning signals for the cortex include
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level. The protomap hypothesis states that the cellular and molecular identity and characteristics of neurons in each cortical area are specified by cortical
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Kostović, Ivica (1990). "Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain".
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hypothesis, first proposed by Rakic. This theory states that new cortical areas are formed by the addition of new radial units, which is accomplished at the
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Hemodynamic changes observed on gyrencephalic brain cortex after an arterial vessel occlusion in IOS. The video has a speed of 50x to better appreciate the
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The cerebral cortex is composed of a heterogenous population of cells that give rise to different cell types. The majority of these cells are derived from
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Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL (2011).
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For species of mammals, larger brains (in absolute terms, not just in relation to body size) tend to have thicker cortices. The smallest mammals, such as
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Braitenberg, V and SchĂŒz, A 1998. "Cortex: Statistics and Geometry of Neuronal Connectivity. Second thoroughly revised edition" New York: Springer-Verlag
2291:'s neuroarchitecture to be reminiscent of the mammalian cerebral cortex. The avian pallium has also been suggested to be an equivalent neural basis for 1955:
In humans, association networks are particularly important to language function. In the past it was theorized that language abilities are localized in
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Rakic, P (November 1972). "Extrinsic cytological determinants of basket and stellate cell dendritic pattern in the cerebellar molecular layer".
1333:. The glial fibers produced in the first divisions of the progenitor cells are radially oriented, spanning the thickness of the cortex from the 7295: 6147: 2012: 542:
is a rim of cortex on the medial side of each hemisphere and is also often included. There are also three lobules of the brain described: the
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Although the majority of the cells that compose the cortex are derived locally from radial glia there is a subset population of neurons that
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The association areas are the parts of the cerebral cortex that do not belong to the primary regions. They function to produce a meaningful
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Rakic, P (1 February 1974). "Neurons in rhesus monkey visual cortex: systematic relation between time of origin and eventual disposition".
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Garel, S; Huffman, KJ; Rubenstein, JL (May 2003). "Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants".
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Rajagopalan, V; Scott, J; Habas, PA; Kim, K; Corbett-Detig, J; Rousseau, F; Barkovich, AJ; Glenn, OA; Studholme, C (23 February 2011).
4029:; Ryan S. Dammerman & Arnold R. Kriegstein (2001). "Neurons derived from radial glial cells establish radial units in neocortex". 3671:"Neocortical neurogenesis is not really "neo": a new evolutionary model derived from a comparative study of chick pallial development" 2875: 2710: 2411: 1161: 2298:
Until recently no counterpart to the cerebral cortex had been recognized in invertebrates. However, a study published in the journal
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Stacho, Martin; Herold, Christina; Rook, Noemi; Wagner, Hermann; Axer, Markus; Amunts, Katrin; GĂŒntĂŒrkĂŒn, Onur (25 September 2020).
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Walsh, Christopher A.; Mochida, Ganeshwaran H. (1 May 2004). "Genetic Basis of Developmental Malformations of the Cerebral Cortex".
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Saladin, Kenneth. Anatomy and Physiology: The Unity of Form and Function, 5th Ed. New York: McGraw-Hill Companies Inc., 2010. Print.
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Bishop, KM; Goudreau, G; O'Leary, DD (14 April 2000). "Regulation of area identity in the mammalian neocortex by Emx2 and Pax6".
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Bishop, KM; Goudreau, G; O'Leary, DD (14 April 2000). "Regulation of area identity in the mammalian neocortex by Emx2 and Pax6".
1700:. Most sensory information is routed to the cerebral cortex via the thalamus. Olfactory information, however, passes through the 196: 3188: 7046: 2085: 1579: 827: 2891:
Toro, Roberto; Perron, Michel; Pike, Bruce; Richer, Louis; Veillette, Suzanne; Pausova, Zdenka; Paus, TomĂĄĆĄ (1 October 2008).
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are called primary sensory areas. The senses of vision, hearing, and touch are served by the primary visual cortex, primary
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In more general terms the cortex is typically described as comprising three parts: sensory, motor, and association areas.
184: 5652: 2376: 1606:, which generates the characteristic folds of the cerebral cortex. Gyrification is regulated by a DNA-associated protein 1365:
The first divisions of the progenitor cells are symmetric, which duplicates the total number of progenitor cells at each
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Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T (March 2022).
2120: 1947:– all located in the posterior part of the cortex – integrate sensory information and information stored in memory. The 1775: 1575: 1530: 1522: 1437:. Next, a cohort of neurons migrating into the middle of the preplate divides this transient layer into the superficial 1302: 5467:"Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study" 1789:
The organization of sensory maps in the cortex reflects that of the corresponding sensing organ, in what is known as a
6714: 4515: 2234:, identified more than 40 different types of cortical neurons based on the distribution of their dendrites and axons. 2156: 1327: 967: 418:
The cerebral cortex is the outer covering of the surfaces of the cerebral hemispheres and is folded into peaks called
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of the mature cerebral cortex is formed during development. The first pyramidal neurons generated migrate out of the
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these same thalamus neurons or ones adjacent to them. One theory is that because the inhibitory output is reduced by
2811:"Gene-environment interactions in cortical interneuron development and dysfunction: A review of preclinical studies" 7288: 7126: 6682: 5745: 2190: 1542:. On the contrary, if mutations in Emx2 occur, it can cause the Pax6-expressing domain to expand and result in the 1314: 930: 920:, contains few large pyramidal neurons and many small spindle-like pyramidal and multiform neurons; layer VI sends 856: 1911:, because together they form a lens-shaped body. The putamen and caudate nucleus are also collectively called the 7085: 6783: 6646: 6627: 3089: 2025: 1866: 1373:, and one progenitor cell, which continues to divide until the end of development, when it differentiates into a 1134: 31: 1778:
respectively. In general, the two hemispheres receive information from the opposite (contralateral) side of the
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migration that form the different cell types of the neocortex and it is a period associated with an increase in
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distinguished 52 different regions of the cerebral cortex based on their cytoarchitecture. These are known as
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do not have a layer IV with axons which would terminate there going instead to the inner part of layer III.
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is completely hidden. The cortex is thickest over the top of a gyrus and thinnest at the bottom of a sulcus.
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The neocortex is separable into different regions of cortex known in the plural as cortices, and include the
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and its functional organisation. In mammals with small brains, there is no folding and the cortex is smooth.
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in 2010, based on gene expression profiles, reported strong affinities between the cerebral cortex and the
1602:. During the period of cortical neurogenesis and layer formation, many higher mammals begin the process of 1430: 776: 7170: 6236: 6134: 6088: 3825:
11: 975–988. "...they either lack (agranular) or have only a rudimentary granular layer IV (dysgranular)."
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Tomer, R; Denes, AS; Tessmar-Raible, K; Arendt, D; Tomer R; Denes AS; Tessmar-Raible K; Arendt D (2010).
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Sur, Mriganka; Leamey, Catherine A. (2001). "Development and Plasticity of Cortical Areas and Networks".
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Frithjof Kruggel; Martina K. BrĂŒckner; Thomas Arendt; Christopher J. Wiggins; D. Yves von Cramon (2003).
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Spreading Depolarizations. We see markedly the front of waves. https://doi.org/10.1007/s00701-019-04132-8
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The allocortex is the part of the cerebral cortex with three or four layers, and has three subtypes, the
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The map of functional cortical areas, which include primary motor and visual cortex, originates from a '
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of the cerebral cortex. The development process is time ordered and regulated by hundreds of genes and
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in the human cerebral cortex. These are organised into horizontal cortical layers, and radially into
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Cauller L (1995). "Layer I of primary sensory neocortex: where top-down converges upon bottom-up".
3132: 2386: 1904: 1818: 1567: 1502: 1422: 1330: 1318: 966:. It has been proposed that the minicolumns are the basic functional units of the cortex. In 1957, 963: 901: 484: 443: 301: 132: 5017:
Rash, Brian G.; Tomasi, Simone; Lim, H. David; Suh, Carol Y.; Vaccarino, Flora M. (26 June 2013).
4748:"FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis" 7165: 6988: 6962: 6563: 6533: 6455: 6387: 6375: 6276: 6272: 6006:, Webvision: Comprehensive article about the structure and function of the primary visual cortex. 5965: 5914: 5851: 5735: 5447: 5242: 5156: 4685: 4642: 4491: 4440: 4229: 4107: 4064: 3703: 3550: 3463: 3369: 3183: 2381: 2261: 2217: 2160: 1935:
of the world, enable us to interact effectively, and support abstract thinking and language. The
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The whole of the cerebral cortex was divided into 52 different areas in an early presentation by
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as their main neurotransmitter. These GABAergic neurons are generated by progenitor cells in the
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Just underneath the cerebral cortex are interconnected subcortical masses of grey matter called
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drain the deoxygenated blood, and metabolic wastes including carbon dioxide, back to the heart.
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the cerebrum. This arterial blood carries oxygen, glucose, and other nutrients to the cortex.
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month-old infant. The Nissl stain shows the cell bodies of neurons; the Golgi stain shows the
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Warren N, Caric D, Pratt T, Clausen JA, Asavaritikrai P, Mason JO, Hill RE, Price DJ (1999).
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Neurogenesis is shown in red and lamination is shown in blue. Adapted from (Sur et al. 2001)
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Rapid expansion of the cortical surface area is regulated by the amount of self-renewal of
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pole. The establishment of this gradient is important for proper development. For example,
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of the nervous system. The most anterior (front, or cranial) part of the neural plate, the
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is the main blood system that deals with blood supply in the cerebrum and cerebral cortex.
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which is a transitional region between the isocortex and the regions of the periallocortex.
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that serves to protect the brain from infection can become compromised allowing entry to
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from other regions. Radial glia give rise to neurons that are pyramidal in shape and use
744:(1909) established that the mammalian neocortex is consistently divided into six layers. 591:, where there are four layers instead of six, is in some instances seen to be related to 5886: 5823: 5381: 5187: 5134: 5087: 4716: 4620: 4573: 4471: 4336: 4044: 3852: 3812:
Quantitative Architecture Distinguishes Prefrontal Cortical Systems in the Rhesus Monkey
3622:"Functional Organization of the Somatosensory Cortical Layer 6 Feedback to the Thalamus" 3085:"Relationships between IQ and Regional Cortical Grey Matter Thickness in Healthy Adults" 2826: 2553: 649: 7396: 7228: 7220: 6952: 6947: 6858: 6687: 6667: 6357: 6288: 5938: 5589: 5564: 5540: 5515: 5491: 5466: 5390: 5365: 5341: 5316: 5051: 5018: 4994: 4961: 4878: 4845: 4821: 4796: 4772: 4747: 4537: 4528: 4510: 4392: 4367: 4298: 4273: 4181: 4156: 3920: 3895: 3871: 3836: 3788: 3646: 3621: 3228: 3203: 3154: 3145: 3127: 2949: 2843: 2810: 2782: 2757: 2675: 2650: 2619: 2594: 2570: 2537: 2500:
Strominger, Norman L.; Demarest, Robert J.; Laemle, Lois B. (2012). "Cerebral Cortex".
2416: 2253: 2205: 2144: 1979: 1944: 1762:
The sensory areas are the cortical areas that receive and process information from the
1701: 1611: 1551: 1462: 1390: 1298: 1211: 1182:
The cerebral cortex develops from the most anterior part, the forebrain region, of the
1119: 1094: 1077: 1041: 972: 811: 780: 768: 760: 535: 531: 476: 458: 368: 356: 317: 5870: 5807: 5760: 3538: 3253:"The neurological basis of developmental dyslexia: an overview and working hypothesis" 3051: 2084:
and problems in later development. Maternal alcohol consumption for example can cause
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Grove, EA; Fukuchi-Shimogori, T (2003). "Generating the cerebral cortical area map".
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Alexandre F.M. DaSilva; Cristina Granziera; Josh Snyder; Nouchine Hadjikhani (2007).
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giving rise to any cell type in the cortex and later progenitors giving rise only to
1073: 1069: 885: 852: 727: 711: 657: 527: 523: 454: 395: 360: 352: 274: 222: 5246: 5160: 4646: 4495: 4444: 4233: 3707: 3554: 2436: 1309:, however these migrating cells contribute neurons that are stellate-shaped and use 1098:
Arterial supply showing the regions supplied by the posterior, middle, and anterior
691:
is formed of six layers, numbered I to VI, from the outermost layer I – near to the
514:
The larger sulci and gyri mark the divisions of the cortex of the cerebrum into the
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but also relate to various functions. An example is Brodmann area 17, which is the
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with other neurons. The axon can develop to extend a long way from the cell body.
410: 17: 5195: 4724: 4479: 3911: 3405: 3388: 2699: 2509: 1056:
There is a transitional area between the neocortex and the allocortex called the
714:. This is a band of whiter tissue that can be observed with the naked eye in the 145: 120: 7345: 7340: 7007: 6056: 5019:"Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain" 3269: 3252: 2834: 2316: 2284: 2269: 2208:, a condition marked by the absence of large parts of the cerebral hemispheres. 2178: 1341:
surface, and provide scaffolding for the migration of neurons outwards from the
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which has four or five, and a transitional area adjacent to the allocortex, the
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can be found here. Inputs to the apical tufts are thought to be crucial for the
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making up the remainder. The cortex is divided into left and right parts by the
5952: 5933: 5531: 5427: 4919: 4902: 4861: 1684:
The cerebral cortex is connected to various subcortical structures such as the
7335: 5989: 5653:"EMX2 empty spiracles homeobox 2 [Homo sapiens (human)] – Gene – NCBI" 5630: 4383: 3739: 3722: 3364: 3347: 2561: 2307: 2257: 1987: 1932: 1813:
in the primary sensory cortex. This last topographic map of the body onto the
1810: 1802: 1779: 1286: 1006: 897: 653: 588: 435: 387: 293: 254: 127: 35: 5902: 5839: 5784: 5727: 5580: 5482: 5435: 5042: 4985: 4938: 4869: 3986: 3969: 3590: 3324: 3219: 2918: 1550:
regions enlarging. Therefore, researchers believe that similar gradients and
779:
and subpial granular layer cells are present in this layer. Also, some spiny
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Jones EG (1998). "Viewpoint: the core and matrix of thalamic organization".
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has been illustrated as a deformed human representation, the somatosensory
475:
The cerebral cortex is folded in a way that allows a large surface area of
5332: 5103: 4589: 4487: 4436: 4428: 4352: 4225: 4217: 3748: 3546: 3481:
Rubio-Garrido P, PĂ©rez-de-Manzo F, Porrero C, Galazo MJ, ClascĂĄ F (2009).
3459: 3348:"The discovery of the subpial granular layer in the human cerebral cortex" 2705:(4th ed.). McGraw-Hill, Health Professions Division. 5 January 2000. 2032:, show as a marker, an atrophy of the grey matter of the cerebral cortex. 457:. About two thirds of the cortical surface is buried in the sulci and the 7206: 6012:, Webvision: Image of the basic cell types of the monkey cerebral cortex. 2273: 2070: 2061:
from disease or trauma, can involve damage to a specific lobe such as in
2044: 1806: 1767: 1685: 1534: 1442: 1382: 1378: 1349: 1290: 764: 733: 723: 642: 607:
Diagram of layers pattern. Cells grouped on left, axonal layers on right.
592: 583: 270: 226: 139: 91: 4929: 1671: 1001:
the cerebral cortex can be classified into two types, the large area of
672: 5684: 3415: 2361: 2135:
There are a number of genetic mutations that can cause a wide range of
2052: 1888: 1656: 1454: 1386: 1366: 1354: 865: 680: 262: 4673: 4157:"Evolution of the neocortex: a perspective from developmental biology" 3690: 3582: 2651:"Evolution of the neocortex: a perspective from developmental biology" 1321:. This migration of GABAergic neurons is particularly important since 6742: 5806:
Nieder, Andreas; Wagener, Lysann; Rinnert, Paul (25 September 2020).
5366:"The anatomy of language: contributions from functional neuroimaging" 4095: 4052: 2201: 2186: 1907:. The putamen and globus pallidus are also collectively known as the 1798: 1763: 1458: 1426: 1281: 1203: 493: 379: 266: 242: 238: 234: 5712:. Kandel, Eric R. (5th ed.). New York. 2013. pp. 347–348. 5074:
Rakic, P (8 July 1988). "Specification of cerebral cortical areas".
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Lui, Jan H.; Hansen, David V.; Kriegstein, Arnold R. (8 July 2011).
4560:
Rakic, P (8 July 1988). "Specification of cerebral cortical areas".
4172: 3204:"Absence of changes in cortical thickness in patients with migraine" 2666: 1655:, in a primordial map. This map is controlled by secreted signaling 1252:–progenitor cells, which divide to produce glial cells and neurons. 1170:
of the cerebral cortex is a complex and finely tuned process called
202: 3894:
Pletikos, Mihovil; Sousa, Andre MM; et al. (22 January 2014).
929:
fibers to neurons in the thalamus and also send collaterals to the
7201: 3128:"Thickening in the somatosensory cortex of patients with migraine" 2170: 2101: 2080:
is susceptible to a range of environmental factors that can cause
1922: 1753: 1670: 1607: 1472: 1404: 1259: 1146: 1093: 983: 671: 648: 610: 602: 563: 419: 409: 324: 230: 103: 62: 5673:
Birth Defects Research. Part A, Clinical and Molecular Teratology
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Rash, BG; Lim, HD; Breunig, JJ; Vaccarino, FM (26 October 2011).
4251:(8th ed.). Sinauer Associates Publishers. pp. 394–395. 3764:"Receptive fields of single neurones in the cat's striate cortex" 1409:
Human cortical development between 26 and 39 week gestational age
1218:
begins, gives rise to the cerebral hemispheres and later cortex.
1174:, influenced by the interplay between genes and the environment. 390:. Cortical areas have specific functions such as movement in the 2758:"Generating Neuronal Diversity in the Mammalian Cerebral Cortex" 2396: 2197: 2182: 2093: 1991: 1571: 1526: 1518: 1510: 1506: 1494: 719: 7277: 6024: 4511:"Development of layer I neurons in the primate cerebral cortex" 277:. The cerebral cortex is the part of the brain responsible for 5995:
Stained brain slice images which include the "cerebral cortex"
5808:"A neural correlate of sensory consciousness in a corvid bird" 5119:"Neocortex patterning by the secreted signaling molecule FGF8" 4605:"Neocortex patterning by the secreted signaling molecule FGF8" 2944:. Progress in Brain Research. Vol. 195. pp. 123–63. 2595:"Cerebral cortex expansion and folding: what have we learned?" 2593:
FernĂĄndez, V; Llinares-Benadero, C; Borrell, V (17 May 2016).
2088:. Other factors that can cause neurodevelopment disorders are 4368:"Epigenetic control on cell fate choice in neural stem cells" 4321:
P. Rakic (1988). "Specification of cerebral cortical areas".
1441:, which will become layer I of the mature neocortex, and the 3947:(Fifth ed.). UK: Oxford University Press. p. 533. 3035: 989:
while that in layer V has a fast 10–15 Hz oscillation.
4008:
Larsen, W J. Human Embryology 3rd edition 2001. pp 421-422
1833:
Two areas of the cortex are commonly referred to as motor:
1766:. Parts of the cortex that receive sensory inputs from the 1505:. Examples of such transcription factors include the genes 833:, and layer III is the principal source of corticocortical 4130:
Sanes, Dan H.; Reh, Thomas A.; Harris, William A. (2012).
2870:(3rd ed.). Williams & Wilkins. pp. 348–358. 718:
of the occipital lobe. The line of Gennari is composed of
570:
relationship between brain weight and cortical thickness.
402:, and the visual cortex is located in the occipital lobe. 335:
and continue to mature after birth through the process of
4272:
Calegari, F; Haubensack W; Haffner C; Huttner WB (2005).
3569:
When There Is No Cytoarchitecturally Distinct Layer 4?".
3389:"Brain states: top-down influences in sensory processing" 1461:, neurogenesis continues throughout the entire period of 904:, which is the main pathway for voluntary motor control. 664:(predominantly blue) is seen at the bottom of the image. 331:(plural sulci). These surface convolutions appear during 5761:"A cortex-like canonical circuit in the avian forebrain" 5305:
Dorland's Medical Dictionary for Health Consumers, 2008.
2364:
monkey. The cerebral cortex is depicted in dark violet.
2181:
are associated with microcephaly. Mutations in the gene
1005:
which has six cell layers, and the much smaller area of
587:
whereby decreased folding in certain areas results in a
1797:, for example, correspond to neighboring points in the 4960:
Wang, Lei; Hou, Shirui; Han, Young-Goo (23 May 2016).
2055:(difficulties in speech expression or comprehension). 1862:
In addition, motor functions have been described for:
1635:
A key theory of cortical evolution is embodied in the
1317:(MGE) that migrate tangentially to the cortex via the 1194:. From the cavity inside the neural tube develops the 446:, in the horizontally organized layers of the cortex. 2893:"Brain Size and Folding of the Human Cerebral Cortex" 695:, to the innermost layer VI – near to the underlying 3293:"Scientists identify a new kind of human brain cell" 7384: 7363: 7312: 7237: 7219: 7189: 7156: 7060: 7015: 7006: 6971: 6940: 6929: 6846: 6776: 6767: 6723: 6675: 6666: 6611: 6556: 6484: 6475: 6400: 6366: 6227: 6220: 6193: 6079: 6072: 6063: 5117:Fukuchi-Shimogori, T; Grove, EA (2 November 2001). 4603:Fukuchi-Shimogori, T; Grove, EA (2 November 2001). 3011:
The central nervous system of vertebrates, Volume 1
2756:Lodato, Simona; Arlotta, Paola (13 November 2015). 1490:', which is regulated by molecular signals such as 1106:Blood supply to the cerebral cortex is part of the 763:. Layer I consists largely of extensions of apical 434:whilst the other 10% made up of three/four-layered 183: 167: 151: 138: 126: 114: 102: 97: 87: 82: 45: 7261:Some categorizations are approximations, and some 4846:"Development and evolution of the human neocortex" 2698: 975:, 1959), auditory cortex, and associative cortex. 754:molecular layer of cerebral cortex|molecular layer 312:. Apart from minimising brain and cranial volume, 27:Outer layer of the cerebrum of the mammalian brain 3009:Nieuwenhuys R, Donkelaar HJ, Nicholson C (1998). 2735:(3rd ed.). Springer-Verlag. pp. 86–92. 2065:, and associated functions will be affected. The 1080:, named from their overlying bones of the skull. 414:Lateral view of cerebrum showing several cortices 1758:Motor and sensory regions of the cerebral cortex 941:input to the cerebral cortex, this provides the 756:, and contains few scattered neurons, including 3810:S.M. Dombrowski, C.C. Hilgetag, and H. Barbas. 3202:Datte R, Detre JA, et al. (October 2011). 2809:Ansen-Wilson, LJ; Lipinski, RJ (January 2017). 2762:Annual Review of Cell and Developmental Biology 2538:"Structure and function of the cerebral cortex" 2476:(3rd ed.). McGraw-Hill. pp. 416–422. 2123:is an invasive procedure that involves placing 1125:The main arteries supplying the cortex are the 978:Cortical areas that lack a layer IV are called 945:with adjustable "gain control for the relay of 855:and pyramidal cells, and is the main target of 398:. The motor cortex is primarily located in the 5869:Herculano-Houzel, Suzana (25 September 2020). 5516:"Fetal Alcohol Spectrum Disorder: An Overview" 5514:Mukherjee, Raja A.S.; Hollins, Sheila (2006). 3179:"Migraine Sufferers Have Thicker Brain Cortex" 2502:Noback's Human Nervous System, Seventh Edition 77:Motor and sensory areas of the cerebral cortex 7289: 6036: 2940:Nieuwenhuys, R (2012). "The insular cortex". 1927:Cortical areas involved in speech processing. 1566:in different areas of the developing cortex, 8: 3723:"The columnar organization of the neocortex" 2644: 2642: 2640: 2638: 2531: 2529: 2495: 2493: 2336:Lateral surface of the human cerebral cortex 771:and horizontally oriented axons, as well as 2348:Medial surface of the human cerebral cortex 2108:, which results in a smooth cortex without 1869:, which guides voluntary movements in space 538:is often included as the insular lobe. The 7296: 7282: 7274: 7012: 6937: 6773: 6672: 6481: 6224: 6076: 6069: 6043: 6029: 6021: 5740:: CS1 maint: location missing publisher ( 3036:"Analyzing the neocortical fine-structure" 3004: 3002: 1236:Cortical neurons are generated within the 323:A fold or ridge in the cortex is termed a 304:that are joined beneath the cortex by the 71: 51: 5951: 5588: 5563:Tarapore, PE; et al. (August 2012). 5539: 5490: 5389: 5340: 5142: 5050: 4993: 4928: 4918: 4877: 4820: 4771: 4628: 4536: 4391: 4297: 4180: 3985: 3919: 3870: 3860: 3787: 3738: 3689: 3678:Development, Growth & Differentiation 3645: 3498: 3414: 3404: 3363: 3268: 3227: 3153: 3102: 3059: 2908: 2842: 2781: 2726: 2724: 2722: 2674: 2618: 2569: 2467: 2465: 2463: 2461: 2459: 2457: 1517:form an opposing gradient of expression. 792:or M-type thalamus cells (in contrast to 615:Three drawings of cortical lamination by 6016:Cerebral Cortex – Cell Centered Database 5871:"Birds do have a brain cortex—and think" 5612: 5610: 5608: 5520:Journal of the Royal Society of Medicine 3520: 3518: 3346:JudaĆĄ, MiloĆĄ; Pletikos, Mihovil (2010). 2360:Tissue slice from the brain of an adult 2248:The cerebral cortex is derived from the 2131:Genes associated with cortical disorders 2011: 1696:and receiving information from them via 1482:(3rd ed.). Burlington: Elsevier Science) 645:and axons of a random subset of neurons. 4025:Stephen C. Noctor; Alexander C. Flint; 2428: 2326: 1624:Pallium (neuroanatomy) § Evolution 572:Magnetic resonance imaging of the brain 327:(plural gyri) and a groove is termed a 5733: 5231:10.1146/annurev.neuro.26.041002.131137 3669:Suzuki, IK; Hirata, T (January 2013). 3615: 3613: 3177:Catharine Paddock (20 November 2007). 2985:(13th. ed.). Wiley. p. 549. 2983:Principles of anatomy & physiology 2037:diseases of the central nervous system 1021:. The neocortex has two subtypes, the 496:have smooth cerebral surfaces without 200: 42: 5704: 5702: 4366:Hu, X.L.; Wang, Y.; Shen, Q. (2012). 4125: 4123: 4121: 2774:10.1146/annurev-cellbio-100814-125353 1809:in the primary auditory cortex and a 1501:expression, through a process called 722:bringing visual information from the 7: 4206:The Journal of Comparative Neurology 3762:Hubel DH, Wiesel TN (October 1959). 2155:can also result causing a number of 1793:. Neighboring points in the primary 1692:, sending information to them along 1445:, forming a middle layer called the 378:There are between 14 and 16 billion 6953:Lateral (frontal+parietal+temporal) 5382:10.1046/j.1469-7580.2000.19730335.x 2252:, a layered structure found in the 1801:. This topographic map is called a 578:. Another study has found that the 483:. When unfolded in the human, each 4529:10.1523/JNEUROSCI.21-15-05607.2001 3146:10.1212/01.wnl.0000291618.32247.2d 2981:Tortora, G; Derrickson, B (2011). 2950:10.1016/B978-0-444-53860-4.00007-6 2504:. Humana Press. pp. 429–451. 2412:List of regions in the human brain 2139:of the cerebral cortex, including 1805:. In the same way, there exists a 1162:Development of the cerebral cortex 900:, and the spinal cord forming the 740:in different species. The work of 660:(predominantly pink). Subcortical 479:to fit within the confines of the 288:makes up approximately 90% of the 25: 5270:"Cerebral cortex - ScienceDirect" 4132:Development of the Nervous System 3191:from the original on 11 May 2008. 2193:, characterised by microcephaly. 1971:, for language expression and in 1570:is disrupted. Specifically, when 1480:Development of the Nervous System 1044:. Examples of allocortex are the 1036:with three cortical laminae, the 892:, whose axons travel through the 518:. There are four main lobes: the 34:. For the cerebellar cortex, see 4417:Journal of Comparative Neurology 3571:Journal of Comparative Neurology 3013:. Springer. pp. 2011–2012. 2353: 2341: 2329: 1915:after their striped appearance. 1395:epigenetic regulatory mechanisms 828:interhemispheric corticocortical 796:or C-type that go to layer IV). 702:One of the clearest examples of 197:Anatomical terms of neuroanatomy 65:(folds and ridges) of the cortex 30:For the scientific journal, see 7047:Posterior parahippocampal gyrus 6989:Collateral (temporal+occipital) 2536:Shipp, Stewart (17 June 2007). 2177:, and disorders in this and in 2086:fetal alcohol spectrum disorder 1675:Some functional areas of cortex 1244:. At first, this zone contains 1009:that has three or four layers: 814:and numerous stellate neurons. 738:laminar structure of the cortex 347:. The four major lobes are the 36:Cerebellum § Gross anatomy 6635:Secondary somatosensory cortex 6327:Ventromedial prefrontal cortex 5035:10.1523/JNEUROSCI.3621-12.2013 4813:10.1523/jneurosci.5458-10.2011 4764:10.1523/jneurosci.4439-11.2011 4290:10.1523/jneurosci.0778-05.2005 3780:10.1113/jphysiol.1959.sp006308 3061:11858/00-001M-0000-0010-9C60-3 2942:Evolution of the Primate Brain 2004:Central nervous system disease 1982:, including the frontal lobe, 1873:Dorsolateral prefrontal cortex 851:, contains different types of 1: 7250:Poles of cerebral hemispheres 6984:Cingulate (frontal+cingulate) 5471:J Neurol Neurosurg Psychiatry 5219:Annual Review of Neuroscience 3539:10.1016/S0306-4522(97)00581-2 3387:Gilbert CD, Sigman M (2007). 3052:10.1016/S1361-8415(03)00006-9 1190:folds and closes to form the 6623:Primary somatosensory cortex 5710:Principles of neural science 5196:10.1126/science.288.5464.344 4725:10.1126/science.288.5464.344 4480:10.1126/science.183.4123.425 3912:10.1016/j.neuron.2013.11.018 3452:10.1016/0166-4328(95)00032-1 3406:10.1016/j.neuron.2007.05.019 2701:Principles of neural science 2510:10.1007/978-1-61779-779-8_25 2157:neurodevelopmental disorders 2121:cortical stimulation mapping 1776:primary somatosensory cortex 1348:At birth there are very few 997:Based on the differences in 241:. It is the largest site of 6715:Transverse occipital sulcus 6004:"The primary visual cortex" 5023:The Journal of Neuroscience 4801:The Journal of Neuroscience 4752:The Journal of Neuroscience 4516:The Journal of Neuroscience 4509:Zecevic N, Rakic P (2001). 4278:The Journal of Neuroscience 4161:Nature Reviews Neuroscience 4084:Nature Reviews Neuroscience 3620:Lam YW, Sherman SM (2010). 2835:10.1016/j.neuro.2016.12.002 2655:Nature Reviews Neuroscience 1594:and is partly regulated by 1529:is highly expressed in the 1521:is highly expressed at the 1457:, in which, in contrast to 1222:Cortical neuron development 363:lobes. Other lobes are the 7439: 7127:Isthmus of cingulate gyrus 6948:Central (frontal+parietal) 6683:Occipital pole of cerebrum 5953:10.1016/j.cell.2010.07.043 5532:10.1177/014107680609900616 5428:10.1007/s00701-019-04132-8 5321:Journal of Neurophysiology 4920:10.1016/j.cell.2013.03.027 4862:10.1016/j.cell.2011.06.030 3352:Translational Neuroscience 2241: 2191:Nijmegen breakage syndrome 2053:different types of aphasia 2026:Neurodegenerative diseases 2001: 1720: 1621: 1315:medial ganglionic eminence 1225: 1214:, which is evident before 1159: 1087: 931:thalamic reticular nucleus 507: 468: 300:, which separates the two 249:, and plays a key role in 29: 7258: 6784:Transverse temporal gyrus 6647:Posterior parietal cortex 5631:10.1001/archneur.61.5.637 4384:10.1007/s13238-012-2916-6 4155:Rakic, P (October 2009). 3945:Principles of development 3768:The Journal of Physiology 3365:10.2478/v10134-010-0037-4 3270:10.1093/brain/123.12.2373 2868:Core text of neuroanatomy 2649:Rakic, P (October 2009). 2562:10.1016/j.cub.2007.03.044 2472:Saladin, Kenneth (2011). 1867:Posterior parietal cortex 1848:Supplementary motor areas 1704:to the olfactory cortex ( 1453:occurs in the layer I of 1135:posterior cerebral artery 1084:Blood supply and drainage 857:thalamocortical afferents 371:often referred to as the 195: 70: 50: 32:Cerebral Cortex (journal) 6905:Inferior temporal sulcus 6826:Superior temporal sulcus 6509:Inferior parietal lobule 6492:Superior parietal lobule 6432:Supplementary motor area 5581:10.3171/2012.5.JNS112124 5483:10.1136/jnnp-2021-326611 3841:Proc Natl Acad Sci U S A 3220:10.1177/0333102411421025 2377:Brain–computer interface 2287:, evidence suggests the 2153:Chromosome abnormalities 2018:spreading depolarization 1731:. These areas, known as 1492:fibroblast growth factor 1127:anterior cerebral artery 882:internal pyramidal layer 824:external pyramidal layer 552:inferior parietal lobule 548:superior parietal lobule 221:, is the outer layer of 7376:External granular layer 7371:Internal granular layer 6910:Inferior temporal gyrus 6854:Occipitotemporal sulcus 6800:Superior temporal gyrus 6693:Lateral occipital gyrus 6444:Supplementary eye field 6185:Inferior frontal sulcus 6180:Superior frontal sulcus 5895:10.1126/science.abe0536 5832:10.1126/science.abb1447 5777:10.1126/science.abc5534 5569:Journal of Neurosurgery 5364:Cathy J. Price (2000). 5144:10.1126/science.1064252 5096:10.1126/science.3291116 4630:10.1126/science.1064252 4582:10.1126/science.3291116 4345:10.1126/science.3291116 4247:Gilbert, Scott (2006). 3943:Wolpert, Lewis (2015). 3862:10.1073/pnas.0903962106 3740:10.1093/brain/120.4.701 2611:10.15252/embj.201593701 2402:Gray matter heterotopia 1815:posterior central gyrus 848:internal granular layer 807:external granular layer 679:neurons in the cortex ( 7171:Fimbria of hippocampus 6237:Superior frontal gyrus 6135:Inferior frontal gyrus 6089:Superior frontal gyrus 3987:10.1093/cercor/9.6.627 3721:Mountcastle V (1997). 3603:Creutzfeldt, O. 1995. 3325:10.1093/cercor/9.8.765 3040:Medical Image Analysis 2232:Santiago Ramon y Cajal 2041:neurological disorders 2022: 2008:Developmental toxicity 1961:inferior frontal gyrus 1928: 1759: 1676: 1637:radial unit hypothesis 1483: 1410: 1265: 1152: 1131:middle cerebral artery 1114:supply the blood that 1103: 775:. During development, 684: 669: 646: 617:Santiago Ramon y Cajal 608: 415: 247:central nervous system 7158:Hippocampal formation 7017:Parahippocampal gyrus 6831:Middle temporal gyrus 5744:) CS1 maint: others ( 5619:Archives of Neurology 5333:10.1152/jn.00338.2011 4429:10.1002/cne.902970309 4249:Developmental biology 4218:10.1002/cne.901460304 3835:Sun W, Dan Y (2009). 3638:10.1093/cercor/bhp077 3500:10.1093/cercor/bhn259 3104:10.1093/cercor/bhl125 2910:10.1093/cercor/bhm261 2441:TheFreeDictionary.com 2312:Platynereis dumerilii 2063:frontal lobe disorder 2015: 2002:Further information: 1998:Clinical significance 1959:in areas of the left 1933:perceptual experience 1926: 1757: 1741:primary visual cortex 1735:, are based on their 1674: 1661:transcription factors 1515:transcription factors 1476: 1431:Cajal–Retzius neurons 1408: 1263: 1248:, that transition to 1226:Further information: 1200:neuroepithelial cells 1151:Cortical blood supply 1150: 1097: 1019:primary visual cortex 726:into layer IV of the 712:primary visual cortex 675: 652: 627:-stained cortex of a 614: 606: 469:Further information: 422:, and grooves called 413: 7131:Retrosplenial cortex 6979:Longitudinal fissure 6871:Medial temporal lobe 6548:Intraparietal sulcus 6408:Primary motor cortex 6305:Orbitofrontal cortex 6254:Medial frontal gyrus 6111:Middle frontal gyrus 5657:www.ncbi.nlm.nih.gov 5416:Acta Neurochirurgica 2228:Rafael Lorente de NĂł 2204:are associated with 2117:electrocorticography 1858:voluntary movements. 1844:voluntary movements 1838:Primary motor cortex 1698:afferent connections 1694:efferent connections 1574:is increased in the 1499:transcription factor 1355:synaptic connections 1331:postsynaptic neurons 1232:Neuroepithelial cell 1168:prenatal development 1108:cerebral circulation 1090:Cerebral circulation 1015:primary motor cortex 999:laminar organization 580:somatosensory cortex 490:longitudinal fissure 302:cerebral hemispheres 298:longitudinal fissure 217:, also known as the 7108:Posterior cingulate 6518:Supramarginal gyrus 5887:2020Sci...369.1567H 5881:(6511): 1567–1568. 5824:2020Sci...369.1626N 5818:(6511): 1626–1629. 5188:2000Sci...288..344B 5135:2001Sci...294.1071F 5088:1988Sci...241..170R 5029:(26): 10802–10814. 4966:Nature Neuroscience 4717:2000Sci...288..344B 4621:2001Sci...294.1071F 4574:1988Sci...241..170R 4472:1974Sci...183..425R 4337:1988Sci...241..170R 4045:2001Natur.409..714N 3853:2009PNAS..10617986S 3847:(42): 17986–17991. 2827:2017NeuTx..58..120A 2731:Roberts, P (1992). 2554:2007CBio...17.R443S 2387:Cortical homunculus 2067:blood–brain barrier 2030:Alzheimer's disease 1905:subthalamic nucleus 1568:cortical patterning 1503:cortical patterning 1469:Cortical patterning 1423:subventricular zone 1361:Asymmetric division 1319:subventricular zone 902:corticospinal tract 777:Cajal–Retzius cells 599:Layers of neocortex 394:, and sight in the 316:is crucial for the 7322:True isocortex or 7166:Hippocampal sulcus 7086:Anterior cingulate 6963:Preoccipital notch 6564:Paracentral lobule 6534:Parietal operculum 6456:Frontal eye fields 6388:Paracentral sulcus 6376:Paracentral lobule 6277:Paraolfactory area 6273:Paraterminal gyrus 6010:"Basic cell types" 5685:10.1002/bdra.23488 5370:Journal of Anatomy 4372:Protein & Cell 4027:Tamily A. Weissman 3817:2008-08-29 at the 3607:. Springer-Verlag. 3184:Medical News Today 2866:Carpenter (1985). 2382:Cortical dysplasia 2218:Korbinian Brodmann 2161:fragile X syndrome 2096:, and exposure to 2049:movement disorders 2023: 1929: 1760: 1729:Korbinian Brodmann 1677: 1653:radial glial cells 1592:radial glial cells 1484: 1411: 1401:Layer organization 1266: 1250:radial glial cells 1202:of its walls, the 1196:ventricular system 1153: 1104: 1017:, and the striate 968:Vernon Mountcastle 742:Korbinian Brodmann 685: 670: 647: 609: 544:paracentral lobule 516:lobes of the brain 510:Lobes of the brain 416: 345:lobes of the brain 243:neural integration 18:Cortical thickness 7410: 7409: 7271: 7270: 7215: 7214: 7040:Postrhinal cortex 7035:Perirhinal cortex 7030:Entorhinal cortex 7002: 7001: 6958:Parieto-occipital 6925: 6924: 6763: 6762: 6662: 6661: 6619:Postcentral gyrus 6471: 6470: 6396: 6395: 6216: 6215: 6208:Precentral sulcus 6171:Pars triangularis 5999:BrainMaps project 4674:10.1242/dev.00416 4331:(4862): 170–176. 4141:978-0-12-374539-2 4039:(6821): 714–720. 3691:10.1111/dgd.12020 3583:10.1002/cne.25652 3299:. 27 August 2018. 3140:(21): 1990–1995. 3020:978-3-540-56013-5 2959:978-0-444-53860-4 2903:(10): 2352–2357. 2519:978-1-61779-778-1 2437:"cerebral mantle" 2323:Additional images 2137:genetic disorders 1919:Association areas 1909:lentiform nucleus 1901:nucleus accumbens 1630:medulla oblongata 1552:signaling centers 1513:. Together, both 1415:layered structure 1246:neural stem cells 1112:Cerebral arteries 1100:cerebral arteries 1058:paralimbic cortex 914:polymorphic layer 862:African elephants 812:pyramidal neurons 810:, contains small 769:pyramidal neurons 704:cortical layering 333:fetal development 211: 210: 206: 16:(Redirected from 7430: 7298: 7291: 7284: 7275: 7197:Indusium griseum 7062:Cingulate cortex 7052:Prepyriform area 7013: 6938: 6818:Planum temporale 6774: 6755:Calcarine sulcus 6673: 6482: 6353:Olfactory sulcus 6339:Subcallosal area 6225: 6203:Precentral gyrus 6162:Pars opercularis 6077: 6070: 6045: 6038: 6031: 6022: 5974: 5973: 5955: 5929: 5923: 5922: 5866: 5860: 5859: 5803: 5797: 5796: 5756: 5750: 5749: 5739: 5731: 5706: 5697: 5696: 5667: 5661: 5660: 5649: 5643: 5642: 5614: 5603: 5602: 5592: 5560: 5554: 5553: 5543: 5511: 5505: 5504: 5494: 5462: 5456: 5455: 5410: 5404: 5403: 5393: 5361: 5355: 5354: 5344: 5327:(3): 1125–1165. 5312: 5306: 5303: 5297: 5294: 5288: 5287: 5280: 5274: 5273: 5266: 5260: 5257: 5251: 5250: 5214: 5208: 5207: 5171: 5165: 5164: 5146: 5129:(5544): 1071–4. 5114: 5108: 5107: 5071: 5065: 5064: 5054: 5014: 5008: 5007: 4997: 4957: 4951: 4950: 4932: 4922: 4898: 4892: 4891: 4881: 4841: 4835: 4834: 4824: 4792: 4786: 4785: 4775: 4758:(43): 15604–17. 4743: 4737: 4736: 4700: 4694: 4693: 4657: 4651: 4650: 4632: 4615:(5544): 1071–4. 4600: 4594: 4593: 4557: 4551: 4550: 4540: 4506: 4500: 4499: 4455: 4449: 4448: 4412: 4406: 4405: 4395: 4363: 4357: 4356: 4318: 4312: 4311: 4301: 4269: 4263: 4262: 4244: 4238: 4237: 4201: 4195: 4194: 4184: 4152: 4146: 4145: 4134:. Elsevier Inc. 4127: 4116: 4115: 4096:10.1038/35067562 4079: 4073: 4072: 4053:10.1038/35055553 4022: 4016: 4006: 4000: 3999: 3989: 3965: 3959: 3958: 3940: 3934: 3933: 3923: 3891: 3885: 3884: 3874: 3864: 3832: 3826: 3808: 3802: 3801: 3791: 3759: 3753: 3752: 3742: 3718: 3712: 3711: 3693: 3675: 3666: 3660: 3659: 3649: 3617: 3608: 3601: 3595: 3594: 3565: 3559: 3558: 3522: 3513: 3512: 3502: 3478: 3472: 3471: 3435: 3429: 3428: 3418: 3408: 3384: 3378: 3377: 3367: 3343: 3337: 3336: 3307: 3301: 3300: 3289: 3283: 3282: 3272: 3251:Habib M (2000). 3248: 3242: 3241: 3231: 3199: 3193: 3192: 3174: 3168: 3167: 3157: 3123: 3117: 3116: 3106: 3097:(9): 2163–2171. 3080: 3074: 3073: 3063: 3031: 3025: 3024: 3006: 2997: 2996: 2978: 2972: 2971: 2937: 2931: 2930: 2912: 2888: 2882: 2881: 2863: 2857: 2856: 2846: 2806: 2800: 2799: 2785: 2753: 2747: 2746: 2728: 2717: 2716: 2704: 2695: 2689: 2688: 2678: 2646: 2633: 2632: 2622: 2599:The EMBO Journal 2590: 2584: 2583: 2573: 2533: 2524: 2523: 2497: 2488: 2487: 2469: 2452: 2451: 2449: 2447: 2433: 2357: 2345: 2333: 2280:, respectively. 2278:olfactory cortex 2078:developing fetus 1897:substantia nigra 1737:cytoarchitecture 1425:, together with 1419:ventricular zone 1371:ventricular zone 1343:ventricular zone 1335:ventricular zone 1307:neurotransmitter 1238:ventricular zone 1198:, and, from the 1142:circle of Willis 1046:olfactory cortex 960:cortical columns 894:internal capsule 716:calcarine sulcus 640: 639: 635: 632: 440:cortical columns 400:precentral gyrus 384:cortical columns 314:cortical folding 284:The six-layered 203:edit on Wikidata 75: 55: 43: 21: 7438: 7437: 7433: 7432: 7431: 7429: 7428: 7427: 7423:Cerebral cortex 7413: 7412: 7411: 7406: 7380: 7359: 7355:Line of Gennari 7313:Structure types 7308: 7306:cerebral cortex 7302: 7272: 7267: 7254: 7233: 7211: 7185: 7152: 7056: 6998: 6994:Callosal sulcus 6972:Medial/inferior 6967: 6932: 6921: 6847:Medial/inferior 6842: 6814:Wernicke's area 6788:Auditory cortex 6759: 6724:Medial/inferior 6719: 6658: 6607: 6603:Marginal sulcus 6557:Medial/inferior 6552: 6467: 6420:Premotor cortex 6392: 6362: 6221:Medial/inferior 6212: 6189: 6059: 6053:cerebral cortex 6051:Anatomy of the 6049: 5982: 5977: 5931: 5930: 5926: 5868: 5867: 5863: 5805: 5804: 5800: 5758: 5757: 5753: 5732: 5720: 5708: 5707: 5700: 5669: 5668: 5664: 5651: 5650: 5646: 5616: 5615: 5606: 5562: 5561: 5557: 5513: 5512: 5508: 5464: 5463: 5459: 5412: 5411: 5407: 5363: 5362: 5358: 5314: 5313: 5309: 5304: 5300: 5295: 5291: 5282: 5281: 5277: 5268: 5267: 5263: 5258: 5254: 5216: 5215: 5211: 5182:(5464): 344–9. 5173: 5172: 5168: 5116: 5115: 5111: 5082:(4862): 170–6. 5073: 5072: 5068: 5016: 5015: 5011: 4978:10.1038/nn.4307 4959: 4958: 4954: 4900: 4899: 4895: 4843: 4842: 4838: 4794: 4793: 4789: 4745: 4744: 4740: 4711:(5464): 344–9. 4702: 4701: 4697: 4659: 4658: 4654: 4602: 4601: 4597: 4568:(4862): 170–6. 4559: 4558: 4554: 4523:(15): 5607–19. 4508: 4507: 4503: 4466:(4123): 425–7. 4457: 4456: 4452: 4414: 4413: 4409: 4365: 4364: 4360: 4320: 4319: 4315: 4271: 4270: 4266: 4259: 4246: 4245: 4241: 4203: 4202: 4198: 4173:10.1038/nrn2719 4154: 4153: 4149: 4142: 4129: 4128: 4119: 4081: 4080: 4076: 4024: 4023: 4019: 4007: 4003: 3974:Cerebral Cortex 3967: 3966: 3962: 3955: 3942: 3941: 3937: 3893: 3892: 3888: 3834: 3833: 3829: 3819:Wayback Machine 3809: 3805: 3761: 3760: 3756: 3720: 3719: 3715: 3673: 3668: 3667: 3663: 3619: 3618: 3611: 3602: 3598: 3567: 3566: 3562: 3524: 3523: 3516: 3493:(10): 2380–95. 3480: 3479: 3475: 3446:(1–2): 163–70. 3440:Behav Brain Res 3437: 3436: 3432: 3386: 3385: 3381: 3345: 3344: 3340: 3313:Cerebral Cortex 3309: 3308: 3304: 3297:Allen Institute 3291: 3290: 3286: 3263:(12): 2373–99. 3250: 3249: 3245: 3201: 3200: 3196: 3176: 3175: 3171: 3125: 3124: 3120: 3090:Cerebral Cortex 3082: 3081: 3077: 3033: 3032: 3028: 3021: 3008: 3007: 3000: 2993: 2980: 2979: 2975: 2960: 2939: 2938: 2934: 2897:Cerebral Cortex 2890: 2889: 2885: 2878: 2865: 2864: 2860: 2815:Neurotoxicology 2808: 2807: 2803: 2755: 2754: 2750: 2743: 2730: 2729: 2720: 2713: 2697: 2696: 2692: 2667:10.1038/nrn2719 2648: 2647: 2636: 2605:(10): 1021–44. 2592: 2591: 2587: 2542:Current Biology 2535: 2534: 2527: 2520: 2499: 2498: 2491: 2484: 2471: 2470: 2455: 2445: 2443: 2435: 2434: 2430: 2426: 2421: 2392:Eloquent cortex 2372: 2365: 2358: 2349: 2346: 2337: 2334: 2325: 2304:mushroom bodies 2246: 2240: 2230:, a student of 2214: 2185:that codes for 2133: 2010: 2000: 1973:Wernicke's area 1945:occipital lobes 1921: 1913:corpus striatum 1893:globus pallidus 1885:caudate nucleus 1852:premotor cortex 1827: 1811:somatotopic map 1803:retinotopic map 1791:topographic map 1772:auditory cortex 1752: 1725: 1719: 1706:piriform cortex 1682: 1669: 1659:and downstream 1626: 1620: 1610:and by FGF and 1523:rostral lateral 1471: 1403: 1391:pyramidal cells 1363: 1258: 1234: 1224: 1180: 1164: 1158: 1092: 1086: 995: 993:Types of cortex 955: 922:efferent fibers 918:multiform layer 910: 878: 843: 822:Layer III, the 820: 802: 761:rosehip neurons 752:Layer I is the 750: 708:line of Gennari 637: 633: 630: 628: 601: 560: 512: 506: 473: 467: 408: 318:brain circuitry 306:corpus callosum 219:cerebral mantle 215:cerebral cortex 207: 160: 78: 66: 46:Cerebral cortex 39: 28: 23: 22: 15: 12: 11: 5: 7436: 7434: 7426: 7425: 7415: 7414: 7408: 7407: 7405: 7404: 7399: 7397:Pyramidal cell 7394: 7388: 7386: 7382: 7381: 7379: 7378: 7373: 7367: 7365: 7361: 7360: 7358: 7357: 7351: 7350: 7349: 7348: 7343: 7333: 7332: 7331: 7326: 7316: 7314: 7310: 7309: 7303: 7301: 7300: 7293: 7286: 7278: 7269: 7268: 7263:Brodmann areas 7259: 7256: 7255: 7253: 7252: 7247: 7241: 7239: 7235: 7234: 7232: 7231: 7229:Insular cortex 7225: 7223: 7221:Insular cortex 7217: 7216: 7213: 7212: 7210: 7209: 7204: 7199: 7193: 7191: 7187: 7186: 7184: 7183: 7178: 7173: 7168: 7162: 7160: 7154: 7153: 7151: 7150: 7149: 7148: 7143: 7138: 7123: 7122: 7121: 7120: 7115: 7105: 7104: 7103: 7098: 7093: 7083: 7082: 7081: 7074:Subgenual area 7070: 7068: 7058: 7057: 7055: 7054: 7049: 7044: 7043: 7042: 7037: 7032: 7021: 7019: 7010: 7004: 7003: 7000: 6999: 6997: 6996: 6991: 6986: 6981: 6975: 6973: 6969: 6968: 6966: 6965: 6960: 6955: 6950: 6944: 6942: 6935: 6933:sulci/fissures 6927: 6926: 6923: 6922: 6920: 6919: 6918: 6917: 6907: 6901: 6900: 6899: 6898: 6893: 6888: 6883: 6878: 6868: 6867: 6866: 6859:Fusiform gyrus 6856: 6850: 6848: 6844: 6843: 6841: 6840: 6839: 6838: 6828: 6823: 6822: 6821: 6807: 6797: 6796: 6795: 6780: 6778: 6771: 6765: 6764: 6761: 6760: 6758: 6757: 6751: 6750: 6745: 6740: 6739: 6738: 6727: 6725: 6721: 6720: 6718: 6717: 6712: 6707: 6706: 6705: 6700: 6690: 6688:Occipital gyri 6685: 6679: 6677: 6670: 6668:Occipital lobe 6664: 6663: 6660: 6659: 6657: 6656: 6655: 6654: 6644: 6643: 6642: 6632: 6631: 6630: 6615: 6613: 6609: 6608: 6606: 6605: 6600: 6599: 6598: 6588: 6587: 6586: 6581: 6576: 6571: 6560: 6558: 6554: 6553: 6551: 6550: 6544: 6543: 6542: 6541: 6531: 6530: 6529: 6520: 6506: 6505: 6504: 6499: 6488: 6486: 6479: 6473: 6472: 6469: 6468: 6466: 6465: 6464: 6463: 6453: 6452: 6451: 6441: 6440: 6439: 6429: 6428: 6427: 6417: 6416: 6415: 6404: 6402: 6398: 6397: 6394: 6393: 6391: 6390: 6385: 6384: 6383: 6372: 6370: 6364: 6363: 6361: 6360: 6358:Orbital sulcus 6355: 6349: 6348: 6347: 6346: 6336: 6335: 6334: 6324: 6323: 6322: 6317: 6312: 6298: 6297: 6296: 6289:Straight gyrus 6286: 6285: 6284: 6269: 6268: 6267: 6266: 6261: 6251: 6250: 6249: 6244: 6233: 6231: 6222: 6218: 6217: 6214: 6213: 6211: 6210: 6205: 6199: 6197: 6191: 6190: 6188: 6187: 6182: 6176: 6175: 6174: 6173: 6164: 6150: 6148:Pars orbitalis 6141: 6131: 6130: 6129: 6128: 6123: 6118: 6108: 6107: 6106: 6101: 6096: 6085: 6083: 6074: 6067: 6061: 6060: 6050: 6048: 6047: 6040: 6033: 6025: 6019: 6018: 6013: 6007: 6001: 5992: 5981: 5980:External links 5978: 5976: 5975: 5946:(5): 800–809. 5924: 5861: 5798: 5751: 5718: 5698: 5662: 5644: 5625:(5): 637–640. 5604: 5555: 5526:(6): 298–302. 5506: 5477:(3): 263–271. 5457: 5422:(3): 581–592. 5405: 5376:(3): 335–359. 5356: 5307: 5298: 5289: 5275: 5261: 5252: 5209: 5166: 5109: 5066: 5009: 4952: 4913:(3): 535–549. 4893: 4836: 4807:(8): 2878–87. 4787: 4738: 4695: 4668:(9): 1903–14. 4652: 4595: 4552: 4501: 4450: 4423:(3): 441–470. 4407: 4378:(4): 278–290. 4358: 4313: 4284:(28): 6533–8. 4264: 4257: 4239: 4196: 4167:(10): 724–35. 4147: 4140: 4117: 4090:(4): 251–262. 4074: 4017: 4001: 3960: 3953: 3935: 3906:(2): 321–332. 3886: 3827: 3803: 3754: 3733:(4): 701–722. 3713: 3661: 3609: 3605:Cortex Cerebri 3596: 3560: 3514: 3473: 3430: 3379: 3358:(3): 255–260. 3338: 3319:(8): 765–775. 3302: 3284: 3243: 3214:(14): 1452–8. 3194: 3169: 3118: 3075: 3046:(3): 251–264. 3026: 3019: 2998: 2991: 2973: 2958: 2932: 2883: 2877:978-0683014556 2876: 2858: 2801: 2768:(1): 699–720. 2748: 2741: 2718: 2712:978-0838577011 2711: 2690: 2661:(10): 724–35. 2634: 2585: 2548:(12): R443–9. 2525: 2518: 2489: 2482: 2453: 2427: 2425: 2422: 2420: 2419: 2417:Insular cortex 2414: 2409: 2404: 2399: 2394: 2389: 2384: 2379: 2373: 2371: 2368: 2367: 2366: 2359: 2352: 2350: 2347: 2340: 2338: 2335: 2328: 2324: 2321: 2239: 2236: 2222:Brodmann areas 2213: 2210: 2206:schizencephaly 2145:schizencephaly 2132: 2129: 1999: 1996: 1980:lateral sulcus 1920: 1917: 1877: 1876: 1870: 1860: 1859: 1845: 1826: 1823: 1751: 1748: 1733:Brodmann areas 1718: 1717:Cortical areas 1715: 1702:olfactory bulb 1681: 1678: 1668: 1665: 1619: 1616: 1578:pole, Emx2 is 1562:. If FGFs are 1548:motor cortical 1470: 1467: 1463:corticogenesis 1447:cortical plate 1402: 1399: 1379:ependymal cell 1362: 1359: 1337:to the outer, 1328:hyperpolarizes 1323:GABA receptors 1257: 1254: 1240:, next to the 1223: 1220: 1212:prosencephalon 1179: 1176: 1172:corticogenesis 1157: 1154: 1120:Cerebral veins 1088:Main article: 1085: 1082: 1078:occipital lobe 1054: 1053: 1042:periallocortex 1030: 1023:true isocortex 994: 991: 954: 951: 912:Layer VI, the 909: 906: 877: 874: 845:Layer IV, the 842: 839: 819: 816: 804:Layer II, the 801: 798: 781:stellate cells 749: 746: 600: 597: 582:is thicker in 559: 556: 536:insular cortex 532:occipital lobe 505: 502: 466: 463: 459:insular cortex 407: 404: 369:insular cortex 209: 208: 199: 193: 192: 187: 181: 180: 171: 165: 164: 155: 149: 148: 143: 136: 135: 130: 124: 123: 118: 112: 111: 109:cortex cerebri 106: 100: 99: 95: 94: 89: 85: 84: 80: 79: 76: 68: 67: 56: 48: 47: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 7435: 7424: 7421: 7420: 7418: 7403: 7402:Stellate cell 7400: 7398: 7395: 7393: 7390: 7389: 7387: 7383: 7377: 7374: 7372: 7369: 7368: 7366: 7362: 7356: 7353: 7352: 7347: 7344: 7342: 7339: 7338: 7337: 7334: 7330: 7327: 7325: 7321: 7320: 7318: 7317: 7315: 7311: 7307: 7299: 7294: 7292: 7287: 7285: 7280: 7279: 7276: 7266: 7264: 7257: 7251: 7248: 7246: 7243: 7242: 7240: 7236: 7230: 7227: 7226: 7224: 7222: 7218: 7208: 7205: 7203: 7200: 7198: 7195: 7194: 7192: 7188: 7182: 7181:Rhinal sulcus 7179: 7177: 7176:Dentate gyrus 7174: 7172: 7169: 7167: 7164: 7163: 7161: 7159: 7155: 7147: 7144: 7142: 7139: 7137: 7134: 7133: 7132: 7128: 7125: 7124: 7119: 7116: 7114: 7111: 7110: 7109: 7106: 7102: 7099: 7097: 7094: 7092: 7089: 7088: 7087: 7084: 7080: 7077: 7076: 7075: 7072: 7071: 7069: 7067: 7063: 7059: 7053: 7050: 7048: 7045: 7041: 7038: 7036: 7033: 7031: 7028: 7027: 7026: 7023: 7022: 7020: 7018: 7014: 7011: 7009: 7005: 6995: 6992: 6990: 6987: 6985: 6982: 6980: 6977: 6976: 6974: 6970: 6964: 6961: 6959: 6956: 6954: 6951: 6949: 6946: 6945: 6943: 6941:Superolateral 6939: 6936: 6934: 6928: 6916: 6913: 6912: 6911: 6908: 6906: 6903: 6902: 6897: 6894: 6892: 6889: 6887: 6884: 6882: 6879: 6877: 6874: 6873: 6872: 6869: 6865: 6862: 6861: 6860: 6857: 6855: 6852: 6851: 6849: 6845: 6837: 6834: 6833: 6832: 6829: 6827: 6824: 6819: 6815: 6811: 6808: 6806: 6803: 6802: 6801: 6798: 6794: 6791: 6790: 6789: 6785: 6782: 6781: 6779: 6777:Superolateral 6775: 6772: 6770: 6769:Temporal lobe 6766: 6756: 6753: 6752: 6749: 6748:Lingual gyrus 6746: 6744: 6741: 6737: 6734: 6733: 6732: 6731:Visual cortex 6729: 6728: 6726: 6722: 6716: 6713: 6711: 6710:Lunate sulcus 6708: 6704: 6701: 6699: 6696: 6695: 6694: 6691: 6689: 6686: 6684: 6681: 6680: 6678: 6676:Superolateral 6674: 6671: 6669: 6665: 6653: 6650: 6649: 6648: 6645: 6641: 6638: 6637: 6636: 6633: 6629: 6626: 6625: 6624: 6620: 6617: 6616: 6614: 6610: 6604: 6601: 6597: 6594: 6593: 6592: 6589: 6585: 6582: 6580: 6577: 6575: 6572: 6570: 6567: 6566: 6565: 6562: 6561: 6559: 6555: 6549: 6546: 6545: 6540: 6537: 6536: 6535: 6532: 6528: 6527:Angular gyrus 6524: 6521: 6519: 6515: 6512: 6511: 6510: 6507: 6503: 6500: 6498: 6495: 6494: 6493: 6490: 6489: 6487: 6485:Superolateral 6483: 6480: 6478: 6477:Parietal lobe 6474: 6462: 6459: 6458: 6457: 6454: 6450: 6447: 6446: 6445: 6442: 6438: 6435: 6434: 6433: 6430: 6426: 6423: 6422: 6421: 6418: 6414: 6411: 6410: 6409: 6406: 6405: 6403: 6399: 6389: 6386: 6382: 6379: 6378: 6377: 6374: 6373: 6371: 6369: 6365: 6359: 6356: 6354: 6351: 6350: 6345: 6342: 6341: 6340: 6337: 6333: 6330: 6329: 6328: 6325: 6321: 6318: 6316: 6313: 6311: 6308: 6307: 6306: 6302: 6299: 6295: 6292: 6291: 6290: 6287: 6283: 6280: 6279: 6278: 6274: 6271: 6270: 6265: 6262: 6260: 6257: 6256: 6255: 6252: 6248: 6245: 6243: 6240: 6239: 6238: 6235: 6234: 6232: 6230: 6226: 6223: 6219: 6209: 6206: 6204: 6201: 6200: 6198: 6196: 6192: 6186: 6183: 6181: 6178: 6177: 6172: 6168: 6165: 6163: 6159: 6156: 6155: 6154: 6151: 6149: 6145: 6142: 6140: 6136: 6133: 6132: 6127: 6124: 6122: 6119: 6117: 6114: 6113: 6112: 6109: 6105: 6102: 6100: 6097: 6095: 6092: 6091: 6090: 6087: 6086: 6084: 6082: 6078: 6075: 6073:Superolateral 6071: 6068: 6066: 6062: 6058: 6054: 6046: 6041: 6039: 6034: 6032: 6027: 6026: 6023: 6017: 6014: 6011: 6008: 6005: 6002: 6000: 5996: 5993: 5991: 5987: 5984: 5983: 5979: 5971: 5967: 5963: 5959: 5954: 5949: 5945: 5941: 5940: 5935: 5928: 5925: 5920: 5916: 5912: 5908: 5904: 5900: 5896: 5892: 5888: 5884: 5880: 5876: 5872: 5865: 5862: 5857: 5853: 5849: 5845: 5841: 5837: 5833: 5829: 5825: 5821: 5817: 5813: 5809: 5802: 5799: 5794: 5790: 5786: 5782: 5778: 5774: 5770: 5766: 5762: 5755: 5752: 5747: 5743: 5737: 5729: 5725: 5721: 5719:9780071390118 5715: 5711: 5705: 5703: 5699: 5694: 5690: 5686: 5682: 5678: 5674: 5666: 5663: 5658: 5654: 5648: 5645: 5640: 5636: 5632: 5628: 5624: 5620: 5613: 5611: 5609: 5605: 5600: 5596: 5591: 5586: 5582: 5578: 5575:(2): 354–62. 5574: 5570: 5566: 5559: 5556: 5551: 5547: 5542: 5537: 5533: 5529: 5525: 5521: 5517: 5510: 5507: 5502: 5498: 5493: 5488: 5484: 5480: 5476: 5472: 5468: 5461: 5458: 5453: 5449: 5445: 5441: 5437: 5433: 5429: 5425: 5421: 5417: 5409: 5406: 5401: 5397: 5392: 5387: 5383: 5379: 5375: 5371: 5367: 5360: 5357: 5352: 5348: 5343: 5338: 5334: 5330: 5326: 5322: 5318: 5311: 5308: 5302: 5299: 5293: 5290: 5285: 5279: 5276: 5271: 5265: 5262: 5256: 5253: 5248: 5244: 5240: 5236: 5232: 5228: 5224: 5220: 5213: 5210: 5205: 5201: 5197: 5193: 5189: 5185: 5181: 5177: 5170: 5167: 5162: 5158: 5154: 5150: 5145: 5140: 5136: 5132: 5128: 5124: 5120: 5113: 5110: 5105: 5101: 5097: 5093: 5089: 5085: 5081: 5077: 5070: 5067: 5062: 5058: 5053: 5048: 5044: 5040: 5036: 5032: 5028: 5024: 5020: 5013: 5010: 5005: 5001: 4996: 4991: 4987: 4983: 4979: 4975: 4972:(7): 888–96. 4971: 4967: 4963: 4956: 4953: 4948: 4944: 4940: 4936: 4931: 4926: 4921: 4916: 4912: 4908: 4904: 4897: 4894: 4889: 4885: 4880: 4875: 4871: 4867: 4863: 4859: 4855: 4851: 4847: 4840: 4837: 4832: 4828: 4823: 4818: 4814: 4810: 4806: 4802: 4798: 4791: 4788: 4783: 4779: 4774: 4769: 4765: 4761: 4757: 4753: 4749: 4742: 4739: 4734: 4730: 4726: 4722: 4718: 4714: 4710: 4706: 4699: 4696: 4691: 4687: 4683: 4679: 4675: 4671: 4667: 4663: 4656: 4653: 4648: 4644: 4640: 4636: 4631: 4626: 4622: 4618: 4614: 4610: 4606: 4599: 4596: 4591: 4587: 4583: 4579: 4575: 4571: 4567: 4563: 4556: 4553: 4548: 4544: 4539: 4534: 4530: 4526: 4522: 4518: 4517: 4512: 4505: 4502: 4497: 4493: 4489: 4485: 4481: 4477: 4473: 4469: 4465: 4461: 4454: 4451: 4446: 4442: 4438: 4434: 4430: 4426: 4422: 4418: 4411: 4408: 4403: 4399: 4394: 4389: 4385: 4381: 4377: 4373: 4369: 4362: 4359: 4354: 4350: 4346: 4342: 4338: 4334: 4330: 4326: 4325: 4317: 4314: 4309: 4305: 4300: 4295: 4291: 4287: 4283: 4279: 4275: 4268: 4265: 4260: 4258:9780878932504 4254: 4250: 4243: 4240: 4235: 4231: 4227: 4223: 4219: 4215: 4212:(3): 335–54. 4211: 4207: 4200: 4197: 4192: 4188: 4183: 4178: 4174: 4170: 4166: 4162: 4158: 4151: 4148: 4143: 4137: 4133: 4126: 4124: 4122: 4118: 4113: 4109: 4105: 4101: 4097: 4093: 4089: 4085: 4078: 4075: 4070: 4066: 4062: 4058: 4054: 4050: 4046: 4042: 4038: 4034: 4033: 4028: 4021: 4018: 4015: 4014:0-443-06583-7 4011: 4005: 4002: 3997: 3993: 3988: 3983: 3980:(6): 627–35. 3979: 3975: 3971: 3964: 3961: 3956: 3954:9780199678143 3950: 3946: 3939: 3936: 3931: 3927: 3922: 3917: 3913: 3909: 3905: 3901: 3897: 3890: 3887: 3882: 3878: 3873: 3868: 3863: 3858: 3854: 3850: 3846: 3842: 3838: 3831: 3828: 3824: 3820: 3816: 3813: 3807: 3804: 3799: 3795: 3790: 3785: 3781: 3777: 3774:(3): 574–91. 3773: 3769: 3765: 3758: 3755: 3750: 3746: 3741: 3736: 3732: 3728: 3724: 3717: 3714: 3709: 3705: 3701: 3697: 3692: 3687: 3684:(1): 173–87. 3683: 3679: 3672: 3665: 3662: 3657: 3653: 3648: 3643: 3639: 3635: 3631: 3627: 3623: 3616: 3614: 3610: 3606: 3600: 3597: 3592: 3588: 3584: 3580: 3576: 3572: 3564: 3561: 3556: 3552: 3548: 3544: 3540: 3536: 3533:(2): 331–45. 3532: 3528: 3521: 3519: 3515: 3510: 3506: 3501: 3496: 3492: 3488: 3484: 3477: 3474: 3469: 3465: 3461: 3457: 3453: 3449: 3445: 3441: 3434: 3431: 3426: 3422: 3417: 3412: 3407: 3402: 3399:(5): 677–96. 3398: 3394: 3390: 3383: 3380: 3375: 3371: 3366: 3361: 3357: 3353: 3349: 3342: 3339: 3334: 3330: 3326: 3322: 3318: 3314: 3306: 3303: 3298: 3294: 3288: 3285: 3280: 3276: 3271: 3266: 3262: 3258: 3254: 3247: 3244: 3239: 3235: 3230: 3225: 3221: 3217: 3213: 3209: 3205: 3198: 3195: 3190: 3186: 3185: 3180: 3173: 3170: 3165: 3161: 3156: 3151: 3147: 3143: 3139: 3135: 3134: 3129: 3122: 3119: 3114: 3110: 3105: 3100: 3096: 3092: 3091: 3086: 3079: 3076: 3071: 3067: 3062: 3057: 3053: 3049: 3045: 3041: 3037: 3030: 3027: 3022: 3016: 3012: 3005: 3003: 2999: 2994: 2992:9780470646083 2988: 2984: 2977: 2974: 2969: 2965: 2961: 2955: 2951: 2947: 2943: 2936: 2933: 2928: 2924: 2920: 2916: 2911: 2906: 2902: 2898: 2894: 2887: 2884: 2879: 2873: 2869: 2862: 2859: 2854: 2850: 2845: 2840: 2836: 2832: 2828: 2824: 2820: 2816: 2812: 2805: 2802: 2798: 2793: 2789: 2784: 2779: 2775: 2771: 2767: 2763: 2759: 2752: 2749: 2744: 2742:9780387977775 2738: 2734: 2727: 2725: 2723: 2719: 2714: 2708: 2703: 2702: 2694: 2691: 2686: 2682: 2677: 2672: 2668: 2664: 2660: 2656: 2652: 2645: 2643: 2641: 2639: 2635: 2630: 2626: 2621: 2616: 2612: 2608: 2604: 2600: 2596: 2589: 2586: 2581: 2577: 2572: 2567: 2563: 2559: 2555: 2551: 2547: 2543: 2539: 2532: 2530: 2526: 2521: 2515: 2511: 2507: 2503: 2496: 2494: 2490: 2485: 2483:9780071222075 2479: 2475: 2474:Human anatomy 2468: 2466: 2464: 2462: 2460: 2458: 2454: 2442: 2438: 2432: 2429: 2423: 2418: 2415: 2413: 2410: 2408: 2407:Limbic system 2405: 2403: 2400: 2398: 2395: 2393: 2390: 2388: 2385: 2383: 2380: 2378: 2375: 2374: 2369: 2363: 2356: 2351: 2344: 2339: 2332: 2327: 2322: 2320: 2318: 2314: 2313: 2309: 2305: 2301: 2296: 2294: 2293:consciousness 2290: 2289:avian pallium 2286: 2281: 2279: 2275: 2271: 2267: 2263: 2259: 2255: 2251: 2245: 2244:Barrel cortex 2238:Other animals 2237: 2235: 2233: 2229: 2225: 2223: 2219: 2211: 2209: 2207: 2203: 2199: 2196:Mutations in 2194: 2192: 2188: 2184: 2180: 2176: 2175:microcephalin 2172: 2168: 2166: 2165:Rett syndrome 2162: 2158: 2154: 2150: 2149:lissencephaly 2147:and types of 2146: 2142: 2138: 2130: 2128: 2126: 2122: 2118: 2113: 2111: 2107: 2106:lissencephaly 2103: 2099: 2095: 2091: 2087: 2083: 2082:birth defects 2079: 2074: 2072: 2068: 2064: 2060: 2056: 2054: 2050: 2046: 2042: 2038: 2033: 2031: 2027: 2019: 2014: 2009: 2005: 1997: 1995: 1993: 1989: 1985: 1984:basal ganglia 1981: 1977: 1974: 1970: 1966: 1962: 1958: 1953: 1950: 1946: 1942: 1938: 1934: 1925: 1918: 1916: 1914: 1910: 1906: 1902: 1898: 1894: 1890: 1886: 1882: 1881:basal ganglia 1874: 1871: 1868: 1865: 1864: 1863: 1857: 1853: 1849: 1846: 1843: 1839: 1836: 1835: 1834: 1831: 1824: 1822: 1820: 1816: 1812: 1808: 1807:tonotopic map 1804: 1800: 1796: 1795:visual cortex 1792: 1787: 1785: 1781: 1777: 1773: 1769: 1765: 1756: 1750:Sensory areas 1749: 1747: 1744: 1742: 1738: 1734: 1730: 1724: 1716: 1714: 1711: 1707: 1703: 1699: 1695: 1691: 1690:basal ganglia 1687: 1679: 1673: 1666: 1664: 1662: 1658: 1654: 1650: 1646: 1642: 1638: 1633: 1631: 1625: 1617: 1615: 1613: 1609: 1605: 1601: 1597: 1593: 1588: 1585: 1581: 1580:downregulated 1577: 1573: 1569: 1565: 1561: 1560:retinoic acid 1557: 1553: 1549: 1545: 1541: 1540:visual cortex 1536: 1532: 1528: 1524: 1520: 1516: 1512: 1508: 1504: 1500: 1496: 1493: 1489: 1481: 1475: 1468: 1466: 1464: 1460: 1456: 1452: 1448: 1444: 1440: 1439:marginal zone 1436: 1432: 1428: 1424: 1420: 1416: 1407: 1400: 1398: 1396: 1392: 1388: 1384: 1380: 1376: 1372: 1368: 1367:mitotic cycle 1360: 1358: 1356: 1351: 1346: 1344: 1340: 1336: 1332: 1329: 1324: 1320: 1316: 1312: 1308: 1304: 1300: 1295: 1292: 1288: 1283: 1279: 1275: 1271: 1262: 1255: 1253: 1251: 1247: 1243: 1239: 1233: 1229: 1221: 1219: 1217: 1213: 1209: 1205: 1201: 1197: 1193: 1189: 1185: 1177: 1175: 1173: 1169: 1163: 1155: 1149: 1145: 1143: 1138: 1136: 1132: 1128: 1123: 1121: 1117: 1113: 1109: 1101: 1096: 1091: 1083: 1081: 1079: 1075: 1074:parietal lobe 1071: 1070:temporal lobe 1067: 1063: 1059: 1051: 1047: 1043: 1039: 1035: 1031: 1028: 1024: 1020: 1016: 1012: 1011: 1010: 1008: 1004: 1000: 992: 990: 988: 985: 981: 976: 974: 969: 965: 961: 952: 950: 948: 944: 940: 936: 932: 928: 923: 919: 915: 907: 905: 903: 899: 895: 891: 887: 886:basal ganglia 883: 880:Layer V, the 875: 873: 871: 867: 863: 858: 854: 850: 849: 840: 838: 836: 832: 829: 825: 817: 815: 813: 809: 808: 799: 797: 795: 791: 786: 782: 778: 774: 770: 766: 762: 759: 755: 747: 745: 743: 739: 735: 731: 729: 728:visual cortex 725: 721: 717: 713: 709: 705: 700: 698: 694: 690: 682: 678: 677:Golgi-stained 674: 667: 663: 659: 658:visual cortex 655: 651: 644: 626: 622: 618: 613: 605: 598: 596: 594: 590: 585: 581: 577: 573: 569: 565: 557: 555: 553: 549: 545: 541: 537: 533: 529: 528:temporal lobe 525: 524:parietal lobe 521: 517: 511: 503: 501: 499: 495: 491: 486: 482: 478: 477:neural tissue 472: 464: 462: 460: 456: 455:visual cortex 452: 447: 445: 441: 437: 433: 429: 425: 421: 412: 405: 403: 401: 397: 396:visual cortex 393: 389: 385: 381: 376: 374: 370: 366: 362: 358: 354: 350: 346: 342: 338: 334: 330: 326: 321: 319: 315: 311: 307: 303: 299: 295: 291: 287: 282: 280: 276: 275:consciousness 272: 268: 264: 260: 256: 252: 248: 244: 240: 236: 232: 228: 224: 223:neural tissue 220: 216: 204: 198: 194: 191: 188: 186: 182: 179: 175: 172: 170: 166: 163: 159: 156: 154: 150: 147: 144: 141: 137: 134: 131: 129: 125: 122: 119: 117: 113: 110: 107: 105: 101: 96: 93: 90: 86: 81: 74: 69: 64: 60: 54: 49: 44: 41: 37: 33: 19: 7329:Proisocortex 7305: 7260: 7024: 6301:Orbital gyri 6153:Broca's area 6065:Frontal lobe 6052: 5943: 5937: 5927: 5878: 5874: 5864: 5815: 5811: 5801: 5768: 5764: 5754: 5709: 5679:(4): 304–7. 5676: 5672: 5665: 5656: 5647: 5622: 5618: 5572: 5568: 5558: 5523: 5519: 5509: 5474: 5470: 5460: 5419: 5415: 5408: 5373: 5369: 5359: 5324: 5320: 5310: 5301: 5292: 5278: 5264: 5255: 5222: 5218: 5212: 5179: 5175: 5169: 5126: 5122: 5112: 5079: 5075: 5069: 5026: 5022: 5012: 4969: 4965: 4955: 4930:10261/338716 4910: 4906: 4896: 4856:(1): 18–36. 4853: 4849: 4839: 4804: 4800: 4790: 4755: 4751: 4741: 4708: 4704: 4698: 4665: 4661: 4655: 4612: 4608: 4598: 4565: 4561: 4555: 4520: 4514: 4504: 4463: 4459: 4453: 4420: 4416: 4410: 4375: 4371: 4361: 4328: 4322: 4316: 4281: 4277: 4267: 4248: 4242: 4209: 4205: 4199: 4164: 4160: 4150: 4131: 4087: 4083: 4077: 4036: 4030: 4020: 4004: 3977: 3973: 3963: 3944: 3938: 3903: 3899: 3889: 3844: 3840: 3830: 3822: 3806: 3771: 3767: 3757: 3730: 3726: 3716: 3681: 3677: 3664: 3632:(1): 13–24. 3629: 3626:Cereb Cortex 3625: 3604: 3599: 3574: 3570: 3563: 3530: 3527:Neuroscience 3526: 3490: 3487:Cereb Cortex 3486: 3476: 3443: 3439: 3433: 3396: 3392: 3382: 3355: 3351: 3341: 3316: 3312: 3305: 3296: 3287: 3260: 3256: 3246: 3211: 3207: 3197: 3182: 3172: 3137: 3131: 3121: 3094: 3088: 3078: 3043: 3039: 3029: 3010: 2982: 2976: 2941: 2935: 2900: 2896: 2886: 2867: 2861: 2818: 2814: 2804: 2795: 2765: 2761: 2751: 2733:Neuroanatomy 2732: 2700: 2693: 2658: 2654: 2602: 2598: 2588: 2545: 2541: 2501: 2473: 2444:. 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Index

Cortical thickness
Cerebral Cortex (journal)
Cerebellum § Gross anatomy

sulci
gyri

Cerebrum
Latin
MeSH
D002540
NeuroNames
39
NeuroLex
birnlex_1494
TA98
A14.1.09.003
A14.1.09.301
TA2
5527
5528
FMA
61830
Anatomical terms of neuroanatomy
edit on Wikidata
neural tissue
cerebrum
brain
humans
mammals

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