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Optimal experimental design

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5912: 3601: 42: 5898: 5936: 5924: 1470:). Working with positive real-numbers brings several advantages: If the estimator of a single parameter has a positive variance, then the variance and the Fisher information are both positive real numbers; hence they are members of the convex cone of nonnegative real numbers (whose nonzero members have reciprocals in this same cone). 1147:
proposed an economic theory of scientific experimentation in 1876, which sought to maximize the precision of the estimates. Peirce's optimal allocation immediately improved the accuracy of gravitational experiments and was used for decades by Peirce and his colleagues. In his 1882 published lecture
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High-quality statistical software provide a combination of libraries of optimal designs or iterative methods for constructing approximately optimal designs, depending on the model specified and the optimality criterion. Users may use a standard optimality-criterion or may program a custom-made
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on an infinite set of observation-locations. Such optimal probability-measure designs solve a mathematical problem that neglected to specify the cost of observations and experimental runs. Nonetheless, such optimal probability-measure designs can be
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to analyze the data, however. Indeed, the "Bayesian" label for probability-based experimental-designs is disliked by some researchers. Alternative terminology for "Bayesian" optimality includes "on-average" optimality or "population" optimality.
1483:(LĂśwner) order. This cone is closed under matrix-matrix addition, under matrix-inversion, and under the multiplication of positive real-numbers and matrices. An exposition of matrix theory and the Loewner-order appears in Pukelsheim. 143:
and is assessed with respect to a statistical criterion, which is related to the variance-matrix of the estimator. Specifying an appropriate model and specifying a suitable criterion function both require understanding of
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Unfortunately practice generally precedes theory, and it is the usual fate of mankind to get things done in some boggling way first, and find out afterward how they could have been done much more easily and perfectly.
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Logic will not undertake to inform you what kind of experiments you ought to make in order best to determine the acceleration of gravity, or the value of the Ohm; but it will tell you how to proceed to form a plan of
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for quadratic models. The Kôno–Kiefer analysis explains why optimal designs for response-surfaces can have discrete supports, which are very similar as do the less efficient designs that have been traditional in
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since the criteria . . . are variance-minimizing criteria, . . . a design that is optimal for a given model using one of the . . . criteria is usually near-optimal for the same model with respect to the other
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When scientists wish to test several theories, then a statistician can design an experiment that allows optimal tests between specified models. Such "discrimination experiments" are especially important in the
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are discussed in Chapter 18 of the textbook by Atkinson, Donev, and Tobias. More advanced discussions occur in the monograph by Fedorov and Hackl, and the articles by Chaloner and Verdinelli and by DasGupta.
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Iterative methods and approximation algorithms are surveyed in the textbook by Atkinson, Donev and Tobias and in the monographs of Fedorov (historical) and Pukelsheim, and in the survey article by Gaffke and
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Designs can be optimized when the design-space is constrained, for example, when the mathematical process-space contains factor-settings that are practically infeasible (e.g. due to safety concerns).
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The choice of an appropriate optimality criterion requires some thought, and it is useful to benchmark the performance of designs with respect to several optimality criteria. Cornell writes that
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of the variance-matrix is called the "information matrix". Because the variance of the estimator of a parameter vector is a matrix, the problem of "minimizing the variance" is complicated. Using
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An introduction to "universal optimality" appears in the textbook of Atkinson, Donev, and Tobias. More detailed expositions occur in the advanced textbook of Pukelsheim and the papers of Kiefer.
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traditional, optimality-criterion, but can specify a custom criterion. In particular, the practitioner can specify a convex criterion using the maxima of convex optimality-criteria and
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acknowledges Wald's influence and results on many pages – 273 (page 55 in the reprinted volume), 280 (62), 289-291 (71-73), 294 (76), 297 (79), 315 (97) 319 (101) – in this article:
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The adjective "optimum" (and not "optimal") "is the slightly older form in English and avoids the construction 'optim(um) + al´—there is no 'optimalis' in Latin" (page x in
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restriction on the number of experimental runs or replications. Some of these methods are discussed by Atkinson, Donev and Tobias and in the paper by Hardin and
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Indeed, there are several classes of designs for which all the traditional optimality-criteria agree, according to the theory of "universal optimality" of
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For several parameters, the covariance-matrices and information-matrices are elements of the convex cone of nonnegative-definite symmetric matrices in a
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Scientific experimentation is an iterative process, and statisticians have developed several approaches to the optimal design of sequential experiments.
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are discussed in the textbook by Atkinson, Donev and Tobias, and in the survey of Gaffke and Heiligers and in the mathematical text of Pukelsheim. The
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Since the optimality criterion of most optimal designs is based on some function of the information matrix, the 'optimality' of a given design is
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The textbook by Atkinson, Donev and Tobias has been used for short courses for industrial practitioners as well as university courses.
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The earliest optimal designs were developed to estimate the parameters of regression models with continuous variables, for example, by
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of the information matrix. This criterion results in minimizing the average variance of the estimates of the regression coefficients.
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would be impractical. Prudent statisticians examine the other optimal designs, whose number of experimental runs differ.
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Shin, Yeonjong; Xiu, Dongbin (2016). "Nonadaptive quasi-optimal points selection for least squares linear regression".
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were surveyed later by S. Zacks. Of course, much work on the optimal design of experiments is related to the theory of
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wrote, "the modern theory of optimum design has its roots in the decision theory school of U.S. statistics founded by
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proposed optimal designs for polynomial models in 1918. (Kirstine Smith had been a student of the Danish statistician
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is explained in an on-line textbook for practitioners, which has many illustrations and statistical applications:
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of optimal designs is discussed in the textbook of Atkinson, Donev and Tobias and also in the monograph by Goos.
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are discussed in the advanced monograph by Shah and Sinha and in the survey-articles by Cheng and by Majumdar.
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have procedures for optimizing a design according to a user's specification. The experimenter must specify a
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Peirce, C. S. (1882), "Introductory Lecture on the Study of Logic" delivered September 1882, published in
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These three advantages (of optimal designs) are documented in the textbook by Atkinson, Donev, and Tobias.
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Optimal designs can accommodate multiple types of factors, such as process, mixture, and discrete factors.
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Quality through design: Experimental design, off-line quality control, and Taguchi's contributions
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Zacks, S. (1996) "Adaptive Designs for Parametric Models". In: Ghosh, S. and Rao, C. R., (Eds) (1996).
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as an optimal design. In practical terms, optimal experiments can reduce the costs of experimentation.
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optimal designs is discussed by Atkinson, Donev, and Tobias and by Pukelsheim (especially Chapter 12).
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are discussed by according to Atkinson, Donev, and Tobias (page 165). These authors also discuss the
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Quality through design: Experimental design, off-line quality control, and Taguchi's contributions
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are discussed in Atkinson, Donev, and Tobias. Mathematically, such results are associated with
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Such benchmarking is discussed in the textbook by Atkinson et al. and in the papers of Kiefer.
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design can be either better or worse than a non-optimal design. Therefore, it is important to
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This criterion maximizes the discrepancy between two proposed models at the design locations.
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In system identification, the following books have chapters on optimal experimental design:
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Guttorp, P.; Lindgren, G. (2009). "Karl Pearson and the Scandinavian school of statistics".
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for the design and an optimality-criterion before the method can compute an optimal design.
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This criterion maximizes a quantity measuring the mutual column orthogonality of X and the
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The Theory of canonical moments with applications in statistics, probability, and analysis
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X(X'X)X'. This has the effect of minimizing the maximum variance of the predicted values.
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See Kiefer ("Optimum Designs for Fitting Biased Multiresponse Surfaces" pages 289–299).
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Traditionally, statisticians have evaluated estimators and designs by considering some
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requires excessive experimental runs when the number of variables exceeds three. Box's
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of parameters, which are estimated via linear combinations of treatment-means in the
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are discussed by Bailey and by Bapat. The first chapter of Bapat's book reviews the
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Peirce, C. S. (July–August 1967). "Note on the Theory of the Economy of Research".
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used by Bailey (or the advanced books below). Bailey's exercises and discussion of
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developed the optimal design of experiments, and so minimized surveyors' need for
3009:"The application of the method of least squares to the interpolation of sequences" 2371:. Springer-Verlag and the Institute of Mathematical Statistics. pp. 718+xxv. 2342: 2760: 2484:. Lecture Notes in Statistics. Vol. 54. Springer-Verlag. pp. 171+viii. 831:
of such an experiment. Such probability-based optimal-designs are called optimal
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allows the practitioner to verify that a given design is globally optimal. The
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Computational methods are discussed by Pukelsheim and by Gaffke and Heiligers.
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In the mathematical theory on optimal experiments, an optimal design can be a
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Experimental design that is optimal with respect to some statistical criterion
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Republication with errata-list and new preface of Wiley (0-471-61971-X) 1993
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and other aspects of "model-robust" designs are discussed by Chang and Notz.
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Boyd and Vandenberghe discuss optimal experimental designs on pages 384–396.
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Experiments with Mixtures: Designs, Models, and the Analysis of Mixture Data
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Boyd and Vandenberghe discuss optimal experimental designs on pages 384–396.
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Memoirs of the Faculty of Science. Kyushu University. Series A. Mathematics
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Optimal designs for "follow-up" experiments are discussed by Wu and Hamada.
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both emphasize statistical concepts (rather than algebraic computations).
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Jack Carl Kiefer: Collected papers III—Design of experiments
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designs (including "Bayesian" designs) are surveyed by Chang and Notz.
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Catalogs of optimal designs occur in books and in software libraries.
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in 1815 (Stigler). In English, two early contributions were made by
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require more experimental runs than do the optimal designs of KĂ´no.
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Stochastic Approximation and Recursive Algorithms and Applications
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Dynamic System Identification: Experiment Design and Data Analysis
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Experiments: Planning, Analysis, and Parameter Design Optimization
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The optimization of sequential experimentation is studied also in
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is much greater than is robustness with respect to changes in the
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Textbooks emphasizing regression and response-surface methodology
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Tchebycheff systems: With applications in analysis and statistics
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The above optimality-criteria are convex functions on domains of
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In some cases, a finite set of observation-locations suffices to
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There are several methods of finding an optimal design, given an
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Majumdar, D. "Optimal and Efficient Treatment-Control Designs".
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In many applications, the statistician is most concerned with a
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Optimal designs reduce the costs of experimentation by allowing
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Draft available on-line. (Especially Chapter 11.8 "Optimality")
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matrix; algebraically, the traditional optimality-criteria are
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Experimental designs are evaluated using statistical criteria.
2336:. Lecture Notes in Statistics. Vol. 125. Springer-Verlag. 3626: 446:
Other optimality-criteria are concerned with the variance of
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X'X of the design. This criterion results in maximizing the
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Jack Carl Kiefer Collected Papers III Design of Experiments
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Some step-size rules for of Judin & Nemirovskii and of
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Jack Carl Kiefer Collected Papers III Design of Experiments
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Identification of Parametric Models from Experimental Data
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of a predetermined linear combination of model parameters.
3071:(1876). "Note on the Theory of the Economy of Research". 1724:
is discussed in Chapter 9 of Atkinson, Donev, and Tobias.
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Gaffke, N. & Heiligers, B. "Approximate Designs for
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The Optimal Design of Blocked and Split-plot Experiments
2631:(Chapter 5 "Block designs and optimality", pages 99–111) 2344:
The Optimal Design of Blocked and Split-plot Experiments
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an optimal design. Such a result was proved by KĂ´no and
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has described methods that are more efficient than the (
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on the models and then select any design maximizing the
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of optimality criteria (since these operations preserve
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Optimal designs offer three advantages over sub-optimal
2856:. Handbook of Statistics. Vol. 13. North-Holland. 2347:. Lecture Notes in Statistics. Vol. 164. Springer. 895:
wrote an overview of optimal sequential designs, while
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Chaloner, Kathryn & Verdinelli, Isabella (1995).
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Atkinson, A. C.; Donev, A. N.; Tobias, R. D. (2007).
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Atkinson, A. C.; Donev, A. N.; Tobias, R. D. (2007).
1937:; Olkin, Ingram; Jerome Sacks; Wynn, Henry P (eds.). 701:
and their computation can use specialized methods of
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Autoregressive conditional heteroskedasticity (ARCH)
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Zacks, S. "Adaptive Designs for Parametric Models".
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Optimal design of experiments: a case study approach
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Books for professional statisticians and researchers
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v. 1, pp. 210–14, see 210–1, also lower down on 211.
2241:, v. 2, n. 19, pp. 11–12, November 1882, see p. 11, 1072:. Of course, fixing the number of experimental runs 604:
Some advanced topics in optimal design require more
120:. A non-optimal design requires a greater number of 5846: 5783: 5736: 5699: 5654: 5636: 5603: 5594: 5552: 5499: 5460: 5409: 5400: 5321: 5278: 5208: 5174: 5128: 5095: 5057: 5024: 4936: 4845: 4764: 4719: 4687: 4640: 4585: 4511: 4502: 4312: 4254: 4228: 4180: 4135: 4082: 3969: 3924: 3898: 3880: 3836: 3788: 3708: 3699: 3453: 3348: 3281: 3191: 464:, which seeks to minimize the maximum entry in the 240:" for that estimator. Because of this reciprocity, 2308:. Society for Industrial and Applied Mathematics. 2156:of optimal probability-measure designs to provide 2117:are explained in the textbook by Kushner and Yin: 2067:Goodwin, Graham C. & Payne, Robert L. (1977). 1973:Journal of the Royal Statistical Society, Series B 1902:Handbook of Statistics, Volume 13. North-Holland. 971:System identification and stochastic approximation 769:and verifying its optimality often are difficult. 608:and practical knowledge in designing experiments. 2219:Dette, Holger & Studden, William J. (1997). 685:Flexible optimality criteria and convex analysis 5087:Multivariate adaptive regression splines (MARS) 1798:See Chapter 20 in Atkinison, Donev, and Tobias. 1574:Boyd, Stephen P.; Vandenberghe, Lieven (2004). 1462:), usually with positive real values (like the 693:All of the traditional optimality-criteria are 657: 651:Choosing an optimality criterion and robustness 2767:Society for Industrial and Applied Mathematics 2463:Society for Industrial and Applied Mathematics 1832:optimality" is advocated in Fedorov and Hackl. 3642: 3169: 2965:"Optimum designs for quadratic regression on 2934:. Handbook of Statistics. pp. 1007–1054. 2925:. Handbook of Statistics. pp. 1149–1199. 2904:. Handbook of Statistics. pp. 1099–1148. 2887:Cheng, C.-S. "Optimal Design: Exact Theory". 2882:. Handbook of Statistics. pp. 1055–1099. 2785:Shah, Kirti R. & Sinha, Bikas K. (1989). 2528:. Oxford University Press. pp. 511+xvi. 2480:Shah, Kirti R. & Sinha, Bikas K. (1989). 2181:, "Markov systems", and "moment spaces": See 2007:Wu, C. F. Jeff & Hamada, Michael (2002). 819:When practitioners need to consider multiple 643:the performance of designs under alternative 487:A second criterion on prediction variance is 172:to be estimated with fewer experimental runs. 8: 2891:. Handbook of Statistics. pp. 977–1006. 1847:"Sequential Tests of Statistical Hypotheses" 1622:are discussed by Atkinson, Donev and Tobias. 510:A third criterion on prediction variance is 55:, while trapped in his tent in storm-ridden 34:. For optimal design in control theory, see 2956:. Handbook of Statistics. pp. 151–180. 1129:In 1815, an article on optimal designs for 627:, its performance may deteriorate on other 623:: While an optimal design is best for that 356:This criterion minimizes the variance of a 5696: 5683: 5600: 5406: 5275: 5250: 5021: 4997: 4725: 4508: 4309: 4296: 4079: 4066: 3705: 3696: 3683: 3649: 3635: 3627: 3176: 3162: 3154: 3085:Collected Papers of Charles Sanders Peirce 2686:Fedorov, Valerii V.; Hackl, Peter (1997). 2332:Fedorov, Valerii V.; Hackl, Peter (1997). 1055:Specifying the number of experimental runs 139:The optimality of a design depends on the 3058: 3028: 3023:from the 1815 French ed.): 439–447. 2987: 2947:. Handbook of Statistics. pp. 63–90. 2830: 2704:Goos, Peter & Jones, Bradley (2011). 2426: 2088:Walter, Éric & Pronzato, Luc (1997). 1862: 1329: 1290: 773:Model uncertainty and Bayesian approaches 545:. More generally, statisticians consider 2813:"Bayesian Experimental Design: A Review" 2505:Textbooks for practitioners and students 1971:(1959). "Optimum Experimental Designs". 1773:symmetric positive-semidefinite matrices 1568:symmetric positive-semidefinite matrices 1528:Atkinson, A. C.; Fedorov, V. V. (1975). 1080:Discretizing probability-measure designs 1887:Sequential Analysis and Optimal Design, 1283: 5613:Kaplan–Meier estimator (product limit) 3019:(4) (Translated by Ralph St. John and 2734:; Jerome Sacks; Wynn, Henry P (eds.). 2655:Sequential Analysis and Optimal Design 2306:Sequential analysis and optimal design 2003:is noted by Wu and Hamada (page 422). 1304:Optimum Experimental Designs, with SAS 1237:Hadamard's maximal determinant problem 1060:Using a computer to find a good design 557:; such linear combinations are called 2411:"The life and work of Gustav Elfving" 2394:. Oxford U. P. pp. 464+xi. 2192:(1953). "Geometry of moment spaces". 1851:The Annals of Mathematical Statistics 183:Minimizing the variance of estimators 7: 5923: 5623:Accelerated failure time (AFT) model 2742:Institute of Mathematical Statistics 2688:Model-Oriented Design of Experiments 2334:Model-Oriented Design of Experiments 2256:v. 4, pp. 378–82, see 378, 379, and 2252:v. 7, paragraphs 59–76, see 59, 63, 1945:Institute of Mathematical Statistics 1495:SIAM Journal on Scientific Computing 1013:, D. Judin & A. Nemirovskii and 951:Pioneering designs for multivariate 857:does not force statisticians to use 5935: 5218:Analysis of variance (ANOVA, anova) 3525:Generalized randomized block design 2567:Textbooks emphasizing block designs 2522:Optimum experimental designs, with 2276:Optimum experimental designs, with 2050:of KĂ´no-type designs for quadratic 1900:Design and Analysis of Experiments, 1784:. Cambridge University Press. 2004. 705:. The practitioner need not select 391:content of the parameter estimates. 5313:Cochran–Mantel–Haenszel statistics 3939:Pearson product-moment correlation 2954:Design and Analysis of Experiments 2945:Design and Analysis of Experiments 2932:Design and Analysis of Experiments 2923:Design and Analysis of Experiments 2902:Design and Analysis of Experiments 2889:Design and Analysis of Experiments 2880:Design and Analysis of Experiments 2854:Design and Analysis of Experiments 2239:Johns Hopkins University Circulars 1306:, by Atkinson, Donev, and Tobias). 25: 3576:Sequential probability ratio test 2789:. Vol. 54. Springer-Verlag. 2708:. Chichester Wiley. p. 304. 2690:. Vol. 125. Springer-Verlag. 2594:Design of Comparative Experiments 761:If an optimality-criterion lacks 5934: 5922: 5910: 5897: 5896: 3599: 3501:Polynomial and rational modeling 2896:DasGupta, A. "Review of Optimal 2616:Linear Algebra and Linear Models 2551:. Oxford U. P. pp. 464+xi. 2169:Regarding designs for quadratic 1340:10.1111/j.1751-5823.2009.00069.x 1318:International Statistical Review 1049:Handbook of Experimental Designs 389:differential Shannon information 275:of the parameter-estimator is a 5572:Least-squares spectral analysis 2409:NordstrĂśm, Kenneth (May 1999). 1454:of the covariance matrix (of a 1232:Glossary of experimental design 846:(where the response follows an 612:Model dependence and robustness 4553:Mean-unbiased minimum-variance 3268:Replication versus subsampling 2759:Pukelsheim, Friedrich (2006). 2208:; Studden, William J. (1966). 1583:. Cambridge University Press. 410:, which maximizes the minimum 358:best linear unbiased estimator 337:, which seeks to minimize the 30:This article is about optimal 1: 5866:Geographic information system 5082:Simultaneous equations models 2762:Optimal Design of Experiments 2679:Theory of Optimal Experiments 2619:(Second ed.). Springer. 2458:Optimal design of experiments 2325:Theory of Optimal Experiments 2254:Writings of Charles S. Peirce 2130:(Second ed.). Springer. 1051:chapter by Shelemyahu Zacks. 695:convex (or concave) functions 209:(under the conditions of the 148:and practical knowledge with 5049:Coefficient of determination 4660:Uniformly most powerful test 3495:Response surface methodology 3403:Analysis of variance (Anova) 3060:10.1016/0315-0860(74)90033-0 3030:10.1016/0315-0860(74)90034-2 2225:. John Wiley & Sons Inc. 1993:response surface methodology 1437:are fundamental concepts in 1257:Response surface methodology 1222:Entropy (information theory) 1187:Bayesian experimental design 1119:response surface methodology 1031:response-surface methodology 921:Response surface methodology 915:Response-surface methodology 815:Bayesian experimental design 809:Bayesian experimental design 69:optimal experimental designs 5998:Statistical process control 5618:Proportional hazards models 5562:Spectral density estimation 5544:Vector autoregression (VAR) 4978:Maximum posterior estimator 4210:Randomized controlled trial 3565:Randomized controlled trial 3090:paragraphs 139–157, and in 2044:"central-composite" designs 965:"central-composite" designs 905:statistical decision theory 315:of the information matrix. 236:) estimator is called the " 6019: 5378:Multivariate distributions 3798:Average absolute deviation 2740:. Springer-Verlag and the 2699:. Vol. 164. Springer. 2173:, the results of KĂ´no and 1943:. Springer-Verlag and the 997:. Popular methods include 974: 918: 877: 812: 781: 530: 524: 429:of the information matrix. 414:of the information matrix. 29: 5983:Mathematical optimization 5892: 5695: 5682: 5366:Structural equation model 5274: 5249: 5020: 4996: 4728: 4702:Score/Lagrange multiplier 4308: 4295: 4117:Sample size determination 4078: 4065: 3695: 3682: 3664: 3584: 2787:Theory of Optimal Designs 2482:Theory of Optimal Designs 2124:; Yin, G. George (2003). 1674:(third ed.). Wiley. 1408:Such criteria are called 866:Iterative experimentation 844:generalized linear models 721:optimality criteria, the 5861:Environmental statistics 5383:Elliptical distributions 5176:Generalized linear model 5105:Simple linear regression 4875:Hodges–Lehmann estimator 4332:Probability distribution 4241:Stochastic approximation 3803:Coefficient of variation 3551:Repeated measures design 3263:Restricted randomization 3121:Smith, Kirstine (1918). 2989:10.2206/kyushumfs.16.114 1616:"parameters of interest" 1614:Optimality criteria for 1361:Smith, Kirstine (1918). 1252:Replication (statistics) 1150:Johns Hopkins University 1114:response-surface designs 999:stochastic approximation 981:Stochastic approximation 842:are used especially for 801:, following the work of 711:nonnegative combinations 600:Practical considerations 194:estimator minimizes the 5521:Cross-correlation (XCF) 5129:Non-standard predictors 4563:Lehmann–ScheffĂŠ theorem 4236:Adaptive clinical trial 2963:KĂ´no, Kazumasa (1962). 2677:Fedorov, V. V. (1972). 2323:Fedorov, V. V. (1972). 2284:Oxford University Press 1864:10.1214/aoms/1177731118 1217:Efficiency (statistics) 1003:stochastic optimization 927:response-surface models 539:"parameter of interest" 460:A popular criterion is 375:A popular criterion is 232:of the variance of an ( 112:allow parameters to be 50:theodolite measurements 6003:Management cybernetics 5988:Industrial engineering 5917:Mathematics portal 5738:Engineering statistics 5646:Nelson–Aalen estimator 5223:Analysis of covariance 5110:Ordinary least squares 5034:Pearson product-moment 4438:Statistical functional 4349:Empirical distribution 4182:Controlled experiments 3911:Frequency distribution 3689:Descriptive statistics 3606:Mathematics portal 3368:Ordinary least squares 2465:. pp. 454+xxxii. 2367:; et al. (eds.). 2353:Kiefer, Jack Carl 1824:As an alternative to " 1670:Cornell, John (2002). 1546:10.1093/biomet/62.1.57 1163: 987:stochastic programming 667: 563:parameters of interest 114:estimated without bias 60: 5963:Design of experiments 5833:Population statistics 5775:System identification 5509:Autocorrelation (ACF) 5437:Exponential smoothing 5351:Discriminant analysis 5346:Canonical correlation 5210:Partition of variance 5072:Regression validation 4916:(Jonckheere–Terpstra) 4815:Likelihood-ratio test 4504:Frequentist inference 4416:Location–scale family 4337:Sampling distribution 4302:Statistical inference 4269:Cross-sectional study 4256:Observational studies 4215:Randomized experiment 4044:Stem-and-leaf display 3846:Central limit theorem 3203:Scientific experiment 3185:Design of experiments 3106:10.1287/opre.15.4.643 2939:Stufken, J. "Optimal 2911:Polynomial Regression 2841:10.1214/ss/1177009939 2805:Articles and chapters 2613:Bapat, R. B. (2000). 2453:Pukelsheim, Friedrich 2428:10.1214/ss/1009212244 2214:. Wiley-Interscience. 2179:Chebyshev polynomials 1212:Design of experiments 1192:Blocking (statistics) 1172:and was working with 1154: 1131:polynomial regression 1007:system identification 1001:and other methods of 977:System identification 823:, they can specify a 551:design of experiments 543:"nuisance parameters" 527:Contrast (statistics) 493:over the design space 190:It is known that the 150:designing experiments 99:design of experiments 83:with respect to some 65:design of experiments 44: 32:design of experiments 5756:Probabilistic design 5341:Principal components 5184:Exponential families 5136:Nonlinear regression 5115:General linear model 5077:Mixed effects models 5067:Errors and residuals 5044:Confounding variable 4946:Bayesian probability 4924:Van der Waerden test 4914:Ordered alternative 4679:Multiple comparisons 4558:Rao–Blackwellization 4521:Estimating equations 4477:Statistical distance 4195:Factorial experiment 3728:Arithmetic-Geometric 3477:Fractional factorial 3088:. Vol. 7. 1958. 3047:Historia Mathematica 3013:Historia Mathematica 2695:Goos, Peter (2002). 2341:Goos, Peter (2002). 2286:. pp. 511+xvi. 2258:The Essential Peirce 2194:Mem. Amer. Math. Soc 1947:. pp. 718+xxv. 1885:Chernoff, H. (1972) 1477:ordered vector space 1135:Joseph Diaz Gergonne 1047:are surveyed in the 925:Optimal designs for 743:is related with the 675:optimality-criterion 555:analysis of variance 211:Gauss–Markov theorem 162:experimental designs 77:experimental designs 5993:Systems engineering 5968:Regression analysis 5828:Official statistics 5751:Methods engineering 5432:Seasonal adjustment 5200:Poisson regressions 5120:Bayesian regression 5059:Regression analysis 5039:Partial correlation 5011:Regression analysis 4610:Prediction interval 4605:Likelihood interval 4595:Confidence interval 4587:Interval estimation 4548:Unbiased estimators 4366:Model specification 4246:Up-and-down designs 3934:Partial correlation 3890:Index of dispersion 3808:Interquartile range 3611:Statistical outline 3571:Sequential analysis 3536:Graeco-Latin square 3445:Multiple comparison 3392:Hierarchical model: 3094:Operations Research 3077:(Appendix No. 14). 3073:Coast Survey Report 3039:Stigler, Stephen M. 2921:, and Optimality". 2818:Statistical Science 2415:Statistical Science 1781:Convex Optimization 1748:in relation to the 1746:equivalence theorem 1722:equivalence theorem 1577:Convex Optimization 1507:2016SJSC...38A.385S 1414:optimization theory 1410:objective functions 1207:Convex minimization 1197:Computer experiment 1086:probability measure 1009:. In computational 885:Sequential analysis 880:Sequential analysis 874:Sequential analysis 825:probability-measure 741:equivalence theorem 730:equivalence theorem 703:convex minimization 582:statistical systems 580:In addition, major 547:linear combinations 5973:Statistical theory 5848:Spatial statistics 5728:Medical statistics 5628:First hitting time 5582:Whittle likelihood 5233:Degrees of freedom 5228:Multivariate ANOVA 5161:Heteroscedasticity 4973:Bayesian estimator 4938:Bayesian inference 4787:Kolmogorov–Smirnov 4672:Randomization test 4642:Testing hypotheses 4615:Tolerance interval 4526:Maximum likelihood 4421:Exponential family 4354:Density estimation 4314:Statistical theory 4274:Natural experiment 4220:Scientific control 4137:Survey methodology 3823:Standard deviation 3616:Statistical topics 3208:Statistical design 3007:(November 1974) . 2728:Brown, Lawrence D. 2597:. Cambridge U. P. 2122:Kushner, Harold J. 2113:2007-10-31 at the 2073:. Academic Press. 2001:Box–Behnken design 1935:Brown, Lawrence D. 1910:. (pages 151–180) 1515:10.1137/15M1015868 1460:unbiased estimator 1439:statistical theory 1427:Fisher information 1242:Information theory 1227:Fisher information 1170:Thorvald N. Thiele 1112:in their works on 961:Box–Behnken design 848:exponential-family 606:statistical theory 533:Nuisance parameter 406:Another design is 385:information matrix 297:summary statistics 293:statistical theory 238:Fisher information 219:statistical models 170:statistical models 146:statistical theory 106:statistical models 61: 36:shape optimization 5978:Optimal decisions 5950: 5949: 5888: 5887: 5884: 5883: 5823:National accounts 5793:Actuarial science 5785:Social statistics 5678: 5677: 5674: 5673: 5670: 5669: 5605:Survival function 5590: 5589: 5452:Granger causality 5293:Contingency table 5268:Survival analysis 5245: 5244: 5241: 5240: 5097:Linear regression 4992: 4991: 4988: 4987: 4963:Credible interval 4932: 4931: 4715: 4714: 4531:Method of moments 4400:Parametric family 4361:Statistical model 4291: 4290: 4287: 4286: 4205:Random assignment 4127:Statistical power 4061: 4060: 4057: 4056: 3906:Contingency table 3876: 3875: 3743:Generalized/power 3624: 3623: 3511:Central composite 3409:Cochran's theorem 3363:Linear regression 3340:Nuisance variable 3253:Random assignment 3230:Experimental unit 3041:(November 1974). 2941:Crossover Designs 2863:978-0-444-82061-7 2796:978-0-387-96991-6 2776:978-0-89871-604-7 2751:978-0-387-96004-3 2724:Kiefer, Jack Carl 2715:978-0-470-74461-1 2681:. Academic Press. 2669:978-0-89871-006-9 2626:978-0-387-98871-9 2604:978-0-521-68357-9 2558:978-0-19-851993-5 2535:978-0-19-929660-6 2491:978-0-387-96991-6 2472:978-0-89871-604-7 2401:978-0-19-851993-5 2378:978-0-387-96004-3 2327:. Academic Press. 2315:978-0-89871-006-9 2293:978-0-19-929660-6 2171:response-surfaces 2137:978-0-387-00894-3 2080:978-0-12-289750-4 2052:response-surfaces 2018:978-0-471-25511-6 1954:978-0-387-96004-3 1931:Kiefer, Jack Carl 1681:978-0-471-07916-3 1590:978-0-521-83378-3 1452:summary statistic 1262:Statistical model 1145:Charles S. Peirce 1133:was published by 1101:optimal designs. 955:were proposed by 953:response-surfaces 942:Charles S. Peirce 903:, especially the 901:optimal decisions 887:was pioneered by 765:, then finding a 541:rather than with 333:One criterion is 265:statistical model 141:statistical model 122:experimental runs 75:) are a class of 16:(Redirected from 6010: 5938: 5937: 5926: 5925: 5915: 5914: 5900: 5899: 5803:Crime statistics 5697: 5684: 5601: 5567:Fourier analysis 5554:Frequency domain 5534: 5481: 5447:Structural break 5407: 5356:Cluster analysis 5303:Log-linear model 5276: 5251: 5192: 5166:Homoscedasticity 5022: 4998: 4917: 4909: 4901: 4900:(Kruskal–Wallis) 4885: 4870: 4825:Cross validation 4810: 4792:Anderson–Darling 4739: 4726: 4697:Likelihood-ratio 4689:Parametric tests 4667:Permutation test 4650:1- & 2-tails 4541:Minimum distance 4513:Point estimation 4509: 4460:Optimal decision 4411: 4310: 4297: 4279:Quasi-experiment 4229:Adaptive designs 4080: 4067: 3944:Rank correlation 3706: 3697: 3684: 3651: 3644: 3637: 3628: 3604: 3603: 3541:Orthogonal array 3178: 3171: 3164: 3155: 3150: 3117: 3089: 3076: 3064: 3062: 3034: 3032: 2993: 2991: 2973: 2957: 2948: 2935: 2926: 2905: 2898:Bayesian Designs 2892: 2883: 2867: 2844: 2834: 2800: 2780: 2765:. 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5517: 5516: 5514:partial (PACF) 5505: 5503: 5497: 5496: 5494: 5493: 5488: 5483: 5475: 5470: 5464: 5462: 5461:Specific tests 5458: 5457: 5455: 5454: 5449: 5444: 5439: 5434: 5429: 5424: 5419: 5413: 5411: 5404: 5398: 5397: 5395: 5394: 5393: 5392: 5391: 5390: 5375: 5374: 5373: 5363: 5361:Classification 5358: 5353: 5348: 5343: 5338: 5333: 5327: 5325: 5319: 5318: 5316: 5315: 5310: 5308:McNemar's test 5305: 5300: 5295: 5290: 5284: 5282: 5272: 5271: 5254: 5247: 5246: 5243: 5242: 5239: 5238: 5236: 5235: 5230: 5225: 5220: 5214: 5212: 5206: 5205: 5203: 5202: 5186: 5180: 5178: 5172: 5171: 5169: 5168: 5163: 5158: 5153: 5148: 5146:Semiparametric 5143: 5138: 5132: 5130: 5126: 5125: 5123: 5122: 5117: 5112: 5107: 5101: 5099: 5093: 5092: 5090: 5089: 5084: 5079: 5074: 5069: 5063: 5061: 5055: 5054: 5052: 5051: 5046: 5041: 5036: 5030: 5028: 5018: 5017: 5014: 5013: 5008: 5002: 5001: 4994: 4993: 4990: 4989: 4986: 4985: 4983: 4982: 4981: 4980: 4970: 4965: 4960: 4959: 4958: 4953: 4942: 4940: 4934: 4933: 4930: 4929: 4927: 4926: 4921: 4920: 4919: 4911: 4903: 4887: 4884:(Mann–Whitney) 4879: 4878: 4877: 4864: 4863: 4862: 4851: 4849: 4843: 4842: 4840: 4839: 4838: 4837: 4832: 4827: 4817: 4812: 4809:(Shapiro–Wilk) 4804: 4799: 4794: 4789: 4784: 4776: 4770: 4768: 4762: 4761: 4759: 4758: 4750: 4741: 4729: 4723: 4721:Specific tests 4717: 4716: 4713: 4712: 4710: 4709: 4704: 4699: 4693: 4691: 4685: 4684: 4682: 4681: 4676: 4675: 4674: 4664: 4663: 4662: 4652: 4646: 4644: 4638: 4637: 4635: 4634: 4633: 4632: 4627: 4617: 4612: 4607: 4602: 4597: 4591: 4589: 4583: 4582: 4580: 4579: 4574: 4573: 4572: 4567: 4566: 4565: 4560: 4545: 4544: 4543: 4538: 4533: 4528: 4517: 4515: 4506: 4500: 4499: 4497: 4496: 4491: 4486: 4485: 4484: 4474: 4469: 4468: 4467: 4457: 4456: 4455: 4450: 4445: 4435: 4430: 4425: 4424: 4423: 4418: 4413: 4397: 4396: 4395: 4390: 4385: 4375: 4374: 4373: 4368: 4358: 4357: 4356: 4346: 4345: 4344: 4334: 4329: 4324: 4318: 4316: 4306: 4305: 4300: 4293: 4292: 4289: 4288: 4285: 4284: 4282: 4281: 4276: 4271: 4266: 4260: 4258: 4252: 4251: 4249: 4248: 4243: 4238: 4232: 4230: 4226: 4225: 4223: 4222: 4217: 4212: 4207: 4202: 4197: 4192: 4186: 4184: 4178: 4177: 4175: 4174: 4172:Standard error 4169: 4164: 4159: 4158: 4157: 4152: 4141: 4139: 4133: 4132: 4130: 4129: 4124: 4119: 4114: 4109: 4104: 4102:Optimal design 4099: 4094: 4088: 4086: 4076: 4075: 4070: 4063: 4062: 4059: 4058: 4055: 4054: 4052: 4051: 4046: 4041: 4036: 4031: 4026: 4021: 4016: 4011: 4006: 4001: 3996: 3991: 3986: 3981: 3975: 3973: 3967: 3966: 3964: 3963: 3958: 3957: 3956: 3951: 3941: 3936: 3930: 3928: 3922: 3921: 3919: 3918: 3913: 3908: 3902: 3900: 3899:Summary tables 3896: 3895: 3893: 3892: 3886: 3884: 3878: 3877: 3874: 3873: 3871: 3870: 3869: 3868: 3863: 3858: 3848: 3842: 3840: 3834: 3833: 3831: 3830: 3825: 3820: 3815: 3810: 3805: 3800: 3794: 3792: 3786: 3785: 3783: 3782: 3777: 3772: 3771: 3770: 3765: 3760: 3755: 3750: 3745: 3740: 3735: 3733:Contraharmonic 3730: 3725: 3714: 3712: 3703: 3693: 3692: 3687: 3680: 3679: 3677: 3676: 3671: 3665: 3662: 3661: 3656: 3654: 3653: 3646: 3639: 3631: 3622: 3621: 3619: 3618: 3613: 3608: 3596: 3591: 3585: 3582: 3581: 3579: 3578: 3573: 3568: 3560: 3559: 3554: 3543: 3538: 3533: 3528: 3522: 3514: 3513: 3508: 3503: 3498: 3490: 3489: 3484: 3479: 3474: 3466: 3464: 3451: 3450: 3448: 3447: 3442: 3436: 3435: 3423: 3411: 3406: 3398: 3397: 3389: 3384: 3376: 3375: 3370: 3365: 3359: 3357: 3346: 3345: 3343: 3342: 3337: 3332: 3325: 3320: 3315: 3310: 3305: 3300: 3292: 3290: 3279: 3278: 3276: 3275: 3270: 3265: 3260: 3255: 3250: 3243:Optimal design 3238: 3237: 3232: 3227: 3215: 3210: 3205: 3199: 3197: 3189: 3188: 3183: 3181: 3180: 3173: 3166: 3158: 3152: 3151: 3118: 3100:(4): 643–648. 3065: 3053:(4): 431–439. 3035: 2999: 2996: 2995: 2994: 2982:(2): 114–122. 2960: 2959: 2958: 2949: 2936: 2927: 2906: 2893: 2884: 2862: 2845: 2832:10.1.1.29.5355 2825:(3): 273–304. 2806: 2803: 2802: 2801: 2795: 2782: 2775: 2756: 2750: 2720: 2714: 2701: 2692: 2683: 2674: 2668: 2644: 2641: 2633: 2632: 2625: 2610: 2603: 2577:linear algebra 2568: 2565: 2564: 2563: 2557: 2540: 2534: 2511: 2508: 2506: 2503: 2501: 2498: 2497: 2496: 2490: 2477: 2471: 2449: 2421:(2): 174–196. 2406: 2400: 2383: 2377: 2349: 2338: 2329: 2320: 2314: 2298: 2292: 2268: 2265: 2263: 2262: 2230: 2228: 2227: 2216: 2206:Karlin, Samuel 2202: 2190:Shapley, Lloyd 2186:Karlin, Samuel 2162: 2154:discretization 2145: 2143: 2142: 2136: 2099: 2097: 2096: 2085: 2079: 2056: 2027: 2024: 2023: 2017: 1984: 1982: 1981: 1960: 1959: 1953: 1912: 1891: 1878: 1857:(2): 117–186. 1834: 1828:optimality", " 1817: 1800: 1791: 1788: 1787: 1771:on domains of 1726: 1706: 1697: 1688: 1680: 1662: 1643: 1634: 1624: 1607: 1604: 1603: 1589: 1559: 1520: 1485: 1443: 1418: 1401: 1392: 1353: 1308: 1295: 1293:, p. 176) 1282: 1280: 1277: 1275: 1274: 1269: 1264: 1259: 1254: 1249: 1244: 1239: 1234: 1229: 1224: 1219: 1214: 1209: 1204: 1199: 1194: 1189: 1183: 1181: 1178: 1166:Kirstine Smith 1126: 1123: 1081: 1078: 1061: 1058: 1056: 1053: 1043:, and optimal 1025:introduced by 972: 969: 946:Kirstine Smith 938:J. D. Gergonne 919:Main article: 916: 913: 878:Main article: 875: 872: 867: 864: 829:expected value 813:Main article: 810: 807: 805:and Atkinson. 779: 776: 774: 771: 767:global optimum 686: 683: 662: 652: 649: 613: 610: 601: 598: 574: 573:Implementation 571: 525:Main article: 522: 519: 518: 517: 516: 515: 498: 497: 496: 475: 474: 473: 444: 443: 442: 441: 432: 431: 430: 417: 416: 415: 394: 393: 392: 363: 362: 361: 348: 347: 346: 322:-optimality (" 289:inverse matrix 184: 181: 180: 179: 176: 173: 157: 154: 132:with the same 92:Kirstine Smith 46:Gustav Elfving 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 6015: 6004: 6001: 5999: 5996: 5994: 5991: 5989: 5986: 5984: 5981: 5979: 5976: 5974: 5971: 5969: 5966: 5964: 5961: 5960: 5958: 5943: 5942: 5933: 5931: 5930: 5921: 5919: 5918: 5913: 5907: 5905: 5904: 5895: 5894: 5891: 5877: 5874: 5872: 5871:Geostatistics 5869: 5867: 5864: 5862: 5859: 5857: 5854: 5853: 5851: 5849: 5845: 5839: 5838:Psychometrics 5836: 5834: 5831: 5829: 5826: 5824: 5821: 5819: 5816: 5814: 5811: 5809: 5806: 5804: 5801: 5799: 5796: 5794: 5791: 5790: 5788: 5786: 5782: 5776: 5773: 5771: 5768: 5766: 5762: 5759: 5757: 5754: 5752: 5749: 5747: 5744: 5743: 5741: 5739: 5735: 5729: 5726: 5724: 5721: 5719: 5715: 5712: 5710: 5707: 5706: 5704: 5702: 5701:Biostatistics 5698: 5694: 5690: 5685: 5681: 5663: 5662:Log-rank test 5660: 5659: 5657: 5653: 5647: 5644: 5643: 5641: 5639: 5635: 5629: 5626: 5624: 5621: 5619: 5616: 5614: 5611: 5610: 5608: 5606: 5602: 5599: 5597: 5593: 5583: 5580: 5578: 5575: 5573: 5570: 5568: 5565: 5563: 5560: 5559: 5557: 5555: 5551: 5545: 5542: 5540: 5537: 5535: 5533:(Box–Jenkins) 5529: 5527: 5524: 5522: 5519: 5515: 5512: 5511: 5510: 5507: 5506: 5504: 5502: 5498: 5492: 5489: 5487: 5486:Durbin–Watson 5484: 5482: 5476: 5474: 5471: 5469: 5468:Dickey–Fuller 5466: 5465: 5463: 5459: 5453: 5450: 5448: 5445: 5443: 5442:Cointegration 5440: 5438: 5435: 5433: 5430: 5428: 5425: 5423: 5420: 5418: 5417:Decomposition 5415: 5414: 5412: 5408: 5405: 5403: 5399: 5389: 5386: 5385: 5384: 5381: 5380: 5379: 5376: 5372: 5369: 5368: 5367: 5364: 5362: 5359: 5357: 5354: 5352: 5349: 5347: 5344: 5342: 5339: 5337: 5334: 5332: 5329: 5328: 5326: 5324: 5320: 5314: 5311: 5309: 5306: 5304: 5301: 5299: 5296: 5294: 5291: 5289: 5288:Cohen's kappa 5286: 5285: 5283: 5281: 5277: 5273: 5269: 5265: 5261: 5257: 5252: 5248: 5234: 5231: 5229: 5226: 5224: 5221: 5219: 5216: 5215: 5213: 5211: 5207: 5201: 5197: 5193: 5187: 5185: 5182: 5181: 5179: 5177: 5173: 5167: 5164: 5162: 5159: 5157: 5154: 5152: 5149: 5147: 5144: 5142: 5141:Nonparametric 5139: 5137: 5134: 5133: 5131: 5127: 5121: 5118: 5116: 5113: 5111: 5108: 5106: 5103: 5102: 5100: 5098: 5094: 5088: 5085: 5083: 5080: 5078: 5075: 5073: 5070: 5068: 5065: 5064: 5062: 5060: 5056: 5050: 5047: 5045: 5042: 5040: 5037: 5035: 5032: 5031: 5029: 5027: 5023: 5019: 5012: 5009: 5007: 5004: 5003: 4999: 4995: 4979: 4976: 4975: 4974: 4971: 4969: 4966: 4964: 4961: 4957: 4954: 4952: 4949: 4948: 4947: 4944: 4943: 4941: 4939: 4935: 4925: 4922: 4918: 4912: 4910: 4904: 4902: 4896: 4895: 4894: 4891: 4890:Nonparametric 4888: 4886: 4880: 4876: 4873: 4872: 4871: 4865: 4861: 4860:Sample median 4858: 4857: 4856: 4853: 4852: 4850: 4848: 4844: 4836: 4833: 4831: 4828: 4826: 4823: 4822: 4821: 4818: 4816: 4813: 4811: 4805: 4803: 4800: 4798: 4795: 4793: 4790: 4788: 4785: 4783: 4781: 4777: 4775: 4772: 4771: 4769: 4767: 4763: 4757: 4755: 4751: 4749: 4747: 4742: 4740: 4735: 4731: 4730: 4727: 4724: 4722: 4718: 4708: 4705: 4703: 4700: 4698: 4695: 4694: 4692: 4690: 4686: 4680: 4677: 4673: 4670: 4669: 4668: 4665: 4661: 4658: 4657: 4656: 4653: 4651: 4648: 4647: 4645: 4643: 4639: 4631: 4628: 4626: 4623: 4622: 4621: 4618: 4616: 4613: 4611: 4608: 4606: 4603: 4601: 4598: 4596: 4593: 4592: 4590: 4588: 4584: 4578: 4575: 4571: 4568: 4564: 4561: 4559: 4556: 4555: 4554: 4551: 4550: 4549: 4546: 4542: 4539: 4537: 4534: 4532: 4529: 4527: 4524: 4523: 4522: 4519: 4518: 4516: 4514: 4510: 4507: 4505: 4501: 4495: 4492: 4490: 4487: 4483: 4480: 4479: 4478: 4475: 4473: 4470: 4466: 4465:loss function 4463: 4462: 4461: 4458: 4454: 4451: 4449: 4446: 4444: 4441: 4440: 4439: 4436: 4434: 4431: 4429: 4426: 4422: 4419: 4417: 4414: 4412: 4406: 4403: 4402: 4401: 4398: 4394: 4391: 4389: 4386: 4384: 4381: 4380: 4379: 4376: 4372: 4369: 4367: 4364: 4363: 4362: 4359: 4355: 4352: 4351: 4350: 4347: 4343: 4340: 4339: 4338: 4335: 4333: 4330: 4328: 4325: 4323: 4320: 4319: 4317: 4315: 4311: 4307: 4303: 4298: 4294: 4280: 4277: 4275: 4272: 4270: 4267: 4265: 4262: 4261: 4259: 4257: 4253: 4247: 4244: 4242: 4239: 4237: 4234: 4233: 4231: 4227: 4221: 4218: 4216: 4213: 4211: 4208: 4206: 4203: 4201: 4198: 4196: 4193: 4191: 4188: 4187: 4185: 4183: 4179: 4173: 4170: 4168: 4167:Questionnaire 4165: 4163: 4160: 4156: 4153: 4151: 4148: 4147: 4146: 4143: 4142: 4140: 4138: 4134: 4128: 4125: 4123: 4120: 4118: 4115: 4113: 4110: 4108: 4105: 4103: 4100: 4098: 4095: 4093: 4090: 4089: 4087: 4085: 4081: 4077: 4073: 4068: 4064: 4050: 4047: 4045: 4042: 4040: 4037: 4035: 4032: 4030: 4027: 4025: 4022: 4020: 4017: 4015: 4012: 4010: 4007: 4005: 4002: 4000: 3997: 3995: 3994:Control chart 3992: 3990: 3987: 3985: 3982: 3980: 3977: 3976: 3974: 3972: 3968: 3962: 3959: 3955: 3952: 3950: 3947: 3946: 3945: 3942: 3940: 3937: 3935: 3932: 3931: 3929: 3927: 3923: 3917: 3914: 3912: 3909: 3907: 3904: 3903: 3901: 3897: 3891: 3888: 3887: 3885: 3883: 3879: 3867: 3864: 3862: 3859: 3857: 3854: 3853: 3852: 3849: 3847: 3844: 3843: 3841: 3839: 3835: 3829: 3826: 3824: 3821: 3819: 3816: 3814: 3811: 3809: 3806: 3804: 3801: 3799: 3796: 3795: 3793: 3791: 3787: 3781: 3778: 3776: 3773: 3769: 3766: 3764: 3761: 3759: 3756: 3754: 3751: 3749: 3746: 3744: 3741: 3739: 3736: 3734: 3731: 3729: 3726: 3724: 3721: 3720: 3719: 3716: 3715: 3713: 3711: 3707: 3704: 3702: 3698: 3694: 3690: 3685: 3681: 3675: 3672: 3670: 3667: 3666: 3663: 3659: 3652: 3647: 3645: 3640: 3638: 3633: 3632: 3629: 3617: 3614: 3612: 3609: 3607: 3602: 3597: 3595: 3592: 3590: 3587: 3586: 3583: 3577: 3574: 3572: 3569: 3567: 3566: 3562: 3561: 3558: 3555: 3553: 3552: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3526: 3523: 3521: 3520: 3516: 3515: 3512: 3509: 3507: 3504: 3502: 3499: 3497: 3496: 3492: 3491: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3472: 3468: 3467: 3465: 3463: 3456: 3452: 3446: 3443: 3441: 3440:Compare means 3438: 3437: 3434: 3432: 3428: 3424: 3422: 3420: 3416: 3412: 3410: 3407: 3405: 3404: 3400: 3399: 3396: 3393: 3390: 3388: 3385: 3383: 3382: 3381:Random effect 3378: 3377: 3374: 3371: 3369: 3366: 3364: 3361: 3360: 3358: 3356: 3351: 3347: 3341: 3338: 3336: 3333: 3331: 3330: 3326: 3324: 3323:Orthogonality 3321: 3319: 3316: 3314: 3311: 3309: 3306: 3304: 3301: 3299: 3298: 3294: 3293: 3291: 3289: 3284: 3280: 3274: 3271: 3269: 3266: 3264: 3261: 3259: 3258:Randomization 3256: 3254: 3251: 3249: 3245: 3244: 3240: 3239: 3236: 3233: 3231: 3228: 3226: 3223: 3219: 3216: 3214: 3211: 3209: 3206: 3204: 3201: 3200: 3198: 3196: 3190: 3186: 3179: 3174: 3172: 3167: 3165: 3160: 3159: 3156: 3148: 3144: 3140: 3136: 3133:(1/2): 1–85. 3132: 3128: 3124: 3119: 3115: 3111: 3107: 3103: 3099: 3095: 3087: 3086: 3080: 3074: 3070: 3066: 3061: 3056: 3052: 3048: 3044: 3040: 3036: 3031: 3026: 3022: 3021:S. M. Stigler 3018: 3014: 3010: 3006: 3002: 3001: 2997: 2990: 2985: 2981: 2977: 2970: 2968: 2961: 2955: 2950: 2946: 2942: 2937: 2933: 2928: 2924: 2920: 2919:Admissibility 2916: 2912: 2907: 2903: 2899: 2894: 2890: 2885: 2881: 2877: 2874: 2869: 2868: 2865: 2859: 2855: 2851: 2846: 2842: 2838: 2833: 2828: 2824: 2820: 2819: 2814: 2809: 2808: 2804: 2798: 2792: 2788: 2783: 2778: 2772: 2768: 2764: 2763: 2757: 2753: 2747: 2743: 2739: 2738: 2733: 2732:Olkin, Ingram 2729: 2725: 2721: 2717: 2711: 2707: 2702: 2698: 2693: 2689: 2684: 2680: 2675: 2671: 2665: 2661: 2657: 2656: 2651: 2647: 2646: 2642: 2640: 2638: 2637:block designs 2628: 2622: 2618: 2617: 2611: 2606: 2600: 2596: 2595: 2590: 2589:Bailey, R. A. 2586: 2585: 2584: 2582: 2581:randomization 2578: 2574: 2573:block designs 2566: 2560: 2554: 2550: 2546: 2541: 2537: 2531: 2527: 2526: 2525: 2517: 2516: 2515: 2509: 2504: 2499: 2493: 2487: 2483: 2478: 2474: 2468: 2464: 2460: 2459: 2454: 2450: 2446: 2442: 2438: 2434: 2429: 2424: 2420: 2416: 2412: 2407: 2403: 2397: 2393: 2389: 2384: 2380: 2374: 2370: 2366: 2365:Sacks, Jerome 2362: 2361:Olkin, Ingram 2358: 2354: 2350: 2346: 2345: 2339: 2335: 2330: 2326: 2321: 2317: 2311: 2307: 2303: 2299: 2295: 2289: 2285: 2281: 2280: 2279: 2271: 2270: 2266: 2259: 2255: 2251: 2247: 2244: 2240: 2234: 2231: 2224: 2223: 2217: 2213: 2212: 2207: 2203: 2199: 2195: 2191: 2187: 2183: 2182: 2180: 2176: 2172: 2166: 2163: 2159: 2158:approximately 2155: 2149: 2146: 2139: 2133: 2129: 2128: 2123: 2119: 2118: 2116: 2112: 2109: 2103: 2100: 2093: 2092: 2086: 2082: 2076: 2072: 2071: 2065: 2064: 2060: 2057: 2053: 2049: 2045: 2041: 2037: 2031: 2028: 2020: 2014: 2010: 2005: 2004: 2002: 1998: 1994: 1988: 1985: 1978: 1974: 1970: 1966: 1965: 1963: 1956: 1950: 1946: 1942: 1941: 1936: 1932: 1928: 1927: 1925: 1921: 1920:Henry P. Wynn 1916: 1913: 1909: 1908:0-444-82061-2 1905: 1901: 1895: 1892: 1888: 1882: 1879: 1874: 1870: 1865: 1860: 1856: 1852: 1848: 1845:(June 1945). 1844: 1843:Wald, Abraham 1838: 1835: 1831: 1827: 1821: 1818: 1814: 1809: 1804: 1801: 1795: 1792: 1786:(book in pdf) 1783: 1782: 1777: 1776: 1774: 1770: 1766: 1762: 1758: 1755: 1751: 1747: 1744: 1740: 1736: 1730: 1727: 1723: 1720: 1716: 1710: 1707: 1701: 1698: 1692: 1689: 1683: 1677: 1673: 1666: 1663: 1659: 1658: 1654: 1647: 1644: 1638: 1635: 1628: 1625: 1621: 1617: 1611: 1608: 1602:(book in pdf) 1592: 1586: 1579: 1578: 1572: 1571: 1569: 1563: 1560: 1555: 1551: 1547: 1543: 1539: 1535: 1531: 1524: 1521: 1516: 1512: 1508: 1504: 1500: 1496: 1489: 1486: 1482: 1478: 1475: 1469: 1465: 1461: 1457: 1453: 1447: 1444: 1440: 1436: 1432: 1428: 1422: 1419: 1415: 1411: 1405: 1402: 1396: 1393: 1388: 1384: 1380: 1376: 1373:(1/2): 1–85. 1372: 1368: 1364: 1357: 1354: 1349: 1345: 1341: 1337: 1332: 1327: 1323: 1319: 1312: 1309: 1305: 1299: 1296: 1292: 1287: 1284: 1278: 1273: 1270: 1268: 1267:Wald, Abraham 1265: 1263: 1260: 1258: 1255: 1253: 1250: 1248: 1245: 1243: 1240: 1238: 1235: 1233: 1230: 1228: 1225: 1223: 1220: 1218: 1215: 1213: 1210: 1208: 1205: 1203: 1200: 1198: 1195: 1193: 1190: 1188: 1185: 1184: 1179: 1177: 1175: 1171: 1167: 1162: 1153: 1151: 1146: 1142: 1140: 1136: 1132: 1124: 1122: 1120: 1115: 1111: 1107: 1102: 1100: 1099:approximately 1096: 1091: 1087: 1079: 1077: 1075: 1071: 1067: 1059: 1054: 1052: 1050: 1046: 1042: 1038: 1034: 1032: 1028: 1024: 1020: 1016: 1012: 1008: 1004: 1000: 996: 992: 988: 982: 978: 970: 968: 966: 962: 958: 954: 949: 947: 943: 939: 934: 932: 928: 922: 914: 912: 910: 906: 902: 898: 894: 890: 886: 881: 873: 871: 865: 863: 860: 856: 853:The use of a 851: 849: 845: 841: 837: 834: 830: 826: 822: 816: 808: 806: 804: 800: 796: 792: 791:biostatistics 785: 777: 772: 770: 768: 764: 759: 757: 753: 750: 746: 742: 739: 735: 731: 728: 724: 720: 716: 712: 708: 704: 700: 696: 691: 684: 682: 680: 676: 672: 661: 656: 650: 648: 646: 642: 638: 634: 630: 626: 622: 620: 611: 609: 607: 599: 597: 595: 591: 587: 583: 578: 572: 570: 568: 564: 560: 556: 552: 548: 544: 540: 534: 528: 520: 513: 509: 508: 506: 503:-optimality ( 502: 499: 494: 490: 486: 485: 483: 480:-optimality ( 479: 476: 471: 467: 463: 459: 458: 456: 453: 452: 451: 449: 439: 438: 436: 433: 428: 424: 423: 421: 418: 413: 409: 405: 404: 402: 399:-optimality ( 398: 395: 390: 386: 382: 378: 374: 373: 371: 368:-optimality ( 367: 364: 359: 355: 354: 352: 349: 344: 340: 336: 332: 331: 329: 325: 321: 318: 317: 316: 314: 310: 306: 302: 298: 294: 290: 286: 282: 278: 274: 270: 266: 261: 259: 258: 254: 249: 248: 244: 239: 235: 231: 227: 224: 220: 216: 212: 208: 205: 201: 197: 193: 192:least squares 188: 182: 177: 174: 171: 167: 166: 165: 163: 155: 153: 151: 147: 142: 137: 135: 131: 127: 123: 119: 115: 111: 107: 104: 100: 95: 93: 89: 86: 82: 78: 74: 70: 66: 58: 54: 51: 47: 43: 37: 33: 19: 5939: 5927: 5908: 5901: 5813:Econometrics 5763: / 5746:Chemometrics 5723:Epidemiology 5716: / 5689:Applications 5531:ARIMA model 5478:Q-statistic 5427:Stationarity 5323:Multivariate 5266: / 5262: / 5260:Multivariate 5258: / 5198: / 5194: / 4968:Bayes factor 4867:Signed rank 4779: 4753: 4745: 4733: 4428:Completeness 4264:Cohort study 4162:Opinion poll 4097:Missing data 4084:Study design 4039:Scatter plot 3961:Scatter plot 3954:Spearman's ρ 3916:Grouped data 3563: 3549: 3531:Latin square 3517: 3493: 3469: 3430: 3426: 3419:multivariate 3418: 3414: 3401: 3379: 3327: 3295: 3241: 3130: 3126: 3097: 3093: 3084: 3072: 3069:Peirce, C. S 3050: 3046: 3016: 3012: 2979: 2975: 2966: 2953: 2944: 2931: 2922: 2901: 2888: 2879: 2853: 2822: 2816: 2786: 2761: 2736: 2705: 2696: 2687: 2678: 2654: 2634: 2615: 2593: 2570: 2548: 2523: 2521: 2513: 2481: 2457: 2418: 2414: 2391: 2368: 2343: 2333: 2324: 2305: 2277: 2275: 2257: 2253: 2249: 2243:Google Books 2242: 2238: 2233: 2221: 2210: 2197: 2193: 2165: 2148: 2126: 2102: 2090: 2069: 2059: 2036:inefficiency 2030: 2008: 1997:inefficiency 1987: 1976: 1972: 1939: 1924:Abraham Wald 1915: 1899: 1894: 1886: 1881: 1854: 1850: 1837: 1829: 1825: 1820: 1803: 1794: 1780: 1765:minimization 1729: 1709: 1700: 1691: 1671: 1665: 1651: 1646: 1637: 1627: 1610: 1594:. Retrieved 1576: 1562: 1540:(1): 57–70. 1537: 1533: 1523: 1498: 1494: 1488: 1479:, under the 1468:matrix trace 1446: 1421: 1404: 1395: 1370: 1366: 1356: 1321: 1317: 1311: 1303: 1298: 1286: 1247:Kiefer, Jack 1176:in London.) 1174:Karl Pearson 1164: 1155: 1143: 1128: 1103: 1083: 1073: 1065: 1063: 1048: 1039:are used in 1035: 1027:G. E. P. Box 1019:Armijo-style 1015:Boris Polyak 984: 950: 935: 924: 909:Abraham Wald 889:Abraham Wald 883: 869: 852: 818: 793:supporting 787: 760: 718: 706: 692: 688: 678: 674: 668: 658: 654: 636: 617: 615: 603: 579: 576: 536: 512:V-optimality 511: 504: 500: 492: 489:I-optimality 488: 481: 477: 462:G-optimality 461: 457:-optimality 454: 445: 437:-optimality 434: 422:-optimality 419: 408:E-optimality 407: 400: 396: 377:D-optimality 376: 369: 365: 353:-optimality 350: 335:A-optimality 334: 327: 323: 319: 267:has several 262: 256: 252: 251: 246: 242: 241: 189: 186: 159: 138: 109: 96: 72: 68: 62: 52: 5941:WikiProject 5856:Cartography 5818:Jurimetrics 5770:Reliability 5501:Time domain 5480:(Ljung–Box) 5402:Time-series 5280:Categorical 5264:Time-series 5256:Categorical 5191:(Bernoulli) 5026:Correlation 5006:Correlation 4802:Jarque–Bera 4774:Chi-squared 4536:M-estimator 4489:Asymptotics 4433:Sufficiency 4200:Interaction 4112:Replication 4092:Effect size 4049:Violin plot 4029:Radar chart 4009:Forest plot 3999:Correlogram 3949:Kendall's τ 3506:Box–Behnken 3387:Mixed model 3318:Confounding 3313:Interaction 3303:Effect size 3273:Sample size 2848:Ghosh, S.; 2545:Wynn, H. P. 2094:. Springer. 1596:October 15, 1464:determinant 1435:functionals 1431:information 1429:and other " 1097:to furnish 1095:discretized 891:. In 1972, 707:exactly one 690:criterion. 631:. On other 553:and in the 448:predictions 427:determinant 381:determinant 370:determinant 313:eigenvalues 309:functionals 305:information 257:information 234:"efficient" 217:theory for 85:statistical 5957:Categories 5808:Demography 5526:ARMA model 5331:Regression 4908:(Friedman) 4869:(Wilcoxon) 4807:Normality 4797:Lilliefors 4744:Student's 4620:Resampling 4494:Robustness 4482:divergence 4472:Efficiency 4410:(monotone) 4405:Likelihood 4322:Population 4155:Stratified 4107:Population 3926:Dependence 3882:Count data 3813:Percentile 3790:Dispersion 3723:Arithmetic 3658:Statistics 3462:randomized 3460:Completely 3431:covariance 3193:Scientific 3127:Biometrika 3075:: 197–201. 2998:Historical 2915:Invariance 2878:Designs". 2850:Rao, C. R. 2726:. (1985). 2267:References 1979:: 272–319. 1969:Kiefer, J. 1830:on-average 1632:Heiligers. 1534:Biometrika 1367:Biometrika 975:See also: 782:See also: 531:See also: 482:integrated 470:hat matrix 412:eigenvalue 401:eigenvalue 301:invariants 269:parameters 253:maximizing 243:minimizing 230:reciprocal 215:estimation 213:). In the 207:estimators 156:Advantages 130:parameters 103:estimating 53:(pictured) 5189:Logistic 4956:posterior 4882:Rank sum 4630:Jackknife 4625:Bootstrap 4443:Bootstrap 4378:Parameter 4327:Statistic 4122:Statistic 4034:Run chart 4019:Pie chart 4014:Histogram 4004:Fan chart 3979:Bar chart 3861:L-moments 3748:Geometric 3471:Factorial 3355:inference 3335:Covariate 3297:Treatment 3283:Treatment 2827:CiteSeerX 2011:. Wiley. 1757:conjugacy 1743:Wolfowitz 1737:to study 1719:Wolfowitz 1620:contrasts 1554:0006-3444 1474:partially 1348:121294724 1326:CiteSeerX 1090:supported 763:convexity 752:conjugacy 738:Wolfowitz 727:Wolfowitz 660:criteria. 641:benchmark 621:dependent 567:contrasts 559:contrasts 521:Contrasts 263:When the 226:parameter 221:with one 134:precision 116:and with 88:criterion 79:that are 57:Greenland 5903:Category 5596:Survival 5473:Johansen 5196:Binomial 5151:Isotonic 4738:(normal) 4383:location 4190:Blocking 4145:Sampling 4024:Q–Q plot 3989:Box plot 3971:Graphics 3866:Skewness 3856:Kurtosis 3828:Variance 3758:Heronian 3753:Harmonic 3594:Category 3589:Glossary 3395:Bayesian 3373:Bayesian 3329:Blocking 3308:Contrast 3288:blocking 3248:Bayesian 3235:Blinding 3225:validity 3222:external 3218:Internal 2652:(1972). 2635:Optimal 2591:(2008). 2571:Optimal 2547:(1989). 2455:(2006). 2390:(1989). 2355:(1985). 2304:(1972). 2111:Archived 2048:blocking 1933:(1985). 1826:Bayesian 1750:Legendre 1618:and for 1180:See also 1088:that is 1074:a priori 1066:a priori 931:blocking 833:Bayesian 745:Legendre 663:—  565:and for 505:variance 466:diagonal 281:variance 279:and its 247:variance 204:unbiased 196:variance 126:estimate 5929:Commons 5876:Kriging 5761:Process 5718:studies 5577:Wavelet 5410:General 4577:Plug-in 4371:L space 4150:Cluster 3851:Moments 3669:Outline 3487:Taguchi 3455:Designs 3213:Control 3147:2331929 2445:1722074 2437:2676737 1999:of the 1873:2235829 1754:Fenchel 1503:Bibcode 1481:Loewner 1387:2331929 1139:Stigler 1125:History 1106:support 995:control 991:systems 989:and in 838:. Such 836:designs 749:Fenchel 717:). For 637:optimal 468:of the 383:of the 343:inverse 341:of the 324:average 311:of the 303:of the 97:In the 81:optimal 63:In the 5798:Census 5388:Normal 5336:Manova 5156:Robust 4906:2-way 4898:1-way 4736:-test 4407:  3984:Biplot 3775:Median 3768:Lehmer 3710:Center 3527:(GRBD) 3427:Ancova 3415:Manova 3350:Models 3195:method 3145:  3114:168276 3112:  2969:-cube" 2876:Robust 2860:  2829:  2793:  2773:  2748:  2712:  2666:  2623:  2601:  2555:  2532:  2488:  2469:  2443:  2435:  2398:  2375:  2312:  2290:  2246:Eprint 2175:Kiefer 2134:  2108:Polyak 2077:  2015:  1995:, the 1962:Kiefer 1951:  1906:  1871:  1739:Kiefer 1715:Kiefer 1678:  1657:robust 1587:  1552:  1385:  1346:  1328:  1324:: 64. 1110:Kiefer 1070:Sloane 821:models 734:Kiefer 723:Kiefer 719:convex 671:Kiefer 645:models 633:models 629:models 287:. The 285:matrix 277:vector 228:, the 5422:Trend 4951:prior 4893:anova 4782:-test 4756:-test 4748:-test 4655:Power 4600:Pivot 4393:shape 4388:scale 3838:Shape 3818:Range 3763:Heinz 3738:Cubic 3674:Index 3519:Block 3143:JSTOR 3110:JSTOR 2972:(PDF) 2873:Model 2433:JSTOR 2357:Brown 1869:JSTOR 1653:Model 1581:(PDF) 1383:JSTOR 1344:S2CID 1279:Notes 679:model 635:, an 625:model 619:model 594:model 584:like 339:trace 328:trace 326:" or 283:is a 5655:Test 4855:Sign 4707:Wald 3780:Mode 3718:Mean 3353:and 3286:and 3220:and 2858:ISBN 2791:ISBN 2771:ISBN 2746:ISBN 2710:ISBN 2664:ISBN 2660:SIAM 2621:ISBN 2599:ISBN 2553:ISBN 2530:ISBN 2486:ISBN 2467:ISBN 2396:ISBN 2373:ISBN 2310:ISBN 2288:ISBN 2152:The 2132:ISBN 2075:ISBN 2034:The 2013:ISBN 1949:ISBN 1904:ISBN 1763:The 1759:for 1713:The 1676:ISBN 1598:2011 1585:ISBN 1550:ISSN 1456:mean 1425:The 993:and 979:and 944:and 797:and 754:for 588:and 273:mean 255:the 245:the 223:real 200:mean 128:the 101:for 71:(or 4835:BIC 4830:AIC 3135:doi 3102:doi 3055:doi 3025:doi 2984:doi 2943:". 2900:". 2837:doi 2524:SAS 2423:doi 2278:SAS 2042:'s 2040:Box 2038:of 1859:doi 1767:of 1542:doi 1511:doi 1466:or 1412:in 1375:doi 1336:doi 1148:at 1029:in 907:of 803:Cox 586:SAS 198:of 124:to 5959:: 3246:: 3141:. 3131:12 3129:. 3125:. 3108:. 3098:15 3096:. 3049:. 3045:. 3015:. 3011:. 2980:16 2978:. 2974:. 2917:, 2913:: 2835:. 2823:10 2821:. 2815:. 2769:. 2744:. 2730:; 2662:. 2658:. 2441:MR 2439:. 2431:. 2419:14 2417:. 2413:. 2363:; 2359:; 2282:. 2198:12 2196:. 2188:; 1977:21 1975:. 1867:. 1855:16 1853:. 1849:. 1548:. 1538:62 1536:. 1532:. 1509:. 1499:38 1497:. 1433:" 1381:. 1371:12 1369:. 1365:. 1342:. 1334:. 1322:77 1320:. 1141:. 1121:. 1033:. 1021:) 948:. 911:. 758:. 681:. 647:. 569:. 507:) 484:) 450:: 403:) 372:) 330:) 260:. 164:: 152:. 108:, 94:. 67:, 4780:G 4754:F 4746:t 4734:Z 4453:V 4448:U 3650:e 3643:t 3636:v 3433:) 3429:( 3421:) 3417:( 3177:e 3170:t 3163:v 3149:. 3137:: 3116:. 3104:: 3063:. 3057:: 3051:1 3033:. 3027:: 3017:1 2992:. 2986:: 2967:k 2871:" 2866:. 2843:. 2839:: 2799:. 2779:. 2754:. 2718:. 2672:. 2629:. 2607:. 2561:. 2538:. 2494:. 2475:. 2447:. 2425:: 2404:. 2381:. 2318:. 2296:. 2200:. 2140:. 2083:. 2054:. 2021:. 1957:. 1875:. 1861:: 1752:- 1741:- 1717:- 1684:. 1655:- 1600:. 1556:. 1544:: 1517:. 1513:: 1505:: 1458:- 1441:. 1416:. 1389:. 1377:: 1350:. 1338:: 747:- 736:- 725:- 590:R 501:V 495:. 478:I 455:G 435:T 420:S 397:E 366:D 351:C 320:A 202:- 59:. 38:. 20:)

Index

D-optimal design
design of experiments
shape optimization
Picture of a man taking measurements with a theodolite in a frozen environment.
Gustav Elfving
theodolite measurements
Greenland
design of experiments
experimental designs
optimal
statistical
criterion
Kirstine Smith
design of experiments
estimating
statistical models
estimated without bias
minimum variance
experimental runs
estimate
parameters
precision
statistical model
statistical theory
designing experiments
experimental designs
statistical models
least squares
variance
mean

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