351:
328:
225:
250:
609:
602:
357:
256:
1548:
42:
1526:
Glucose breakdown produces ROS, which leads to Daxx production and relocalization, activating JNK pathway in turn. Another inducer of Daxx production is the exposure to UV-radiation. ASK1 will be transported to the nucleus when UV-irradiation is used to treat the cell. It is still unknown as to
1479:) pathway. This pathway normally regulates stress-induced cell death. It is also essential for development of nerval system by programmed cell death. The real apoptotic process starts after activating this pathway. Daxx does not activate JNK itself but rather the upstream JNK kinase kinase
1434:, a centromeric heterochromatin component co-localizes with Daxx. This partnership is found mainly in the S-phase of the cell cycle. No expression of Daxx leads to malfunction of S phase and cells with two nuclei are formed. Another centromeric component, CENP-C, associates with Daxx during
68:
1539:
A rather surprising property of Daxx is its anti-apoptotic function. When Daxx was not expressed or disrupted during embryonic development, it resulted in an early stage lethality. Other studies showed that lack of Daxx gene caused a higher apoptotic rate in
1385:). In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or
1610:
ENSG00000206206, ENSG00000227046, ENSG00000206279, ENSG00000204209, ENSG00000229396 GRCh38: Ensembl release 89: ENSG00000231617, ENSG00000206206, ENSG00000227046, ENSG00000206279, ENSG00000204209, ENSG00000229396
1421:, where it interacts with some subnuclear structures. Several additional interacting proteins are known, but not always is there an understanding of the specific function and relevance of this interaction.
1429:
When the PML-NB is absent or disrupted, Daxx is delocalized and apoptosis does not occur. This interaction was demonstrated when PML-NB disrupted cells were treated and Daxx relocalized with the PML-NB.
1527:
whether ASK1 binds Daxx, due to UV-irradiation. Another important cell death-property of Daxx is the association with PML-NB. It was shown that Daxx associates with Pml only when exposed to high
1397:. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including
1462:. This transport mechanism is phosphorylation dependent. Nevertheless, it is not known whether the Fas-receptor stimuli or the ASK1 overexpression are caused by ROS or CRM1 mediated export.
1683:
Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF (1997). "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region".
2300:
2159:
Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA (2001). "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation".
1921:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
364:
263:
2637:
2544:
2365:
1498:
regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and cell death. Daxx interacts with the
2265:
1438:. While at first Daxx was said to be a "death protein", it is suggested that associating with centromeric components leads to another function of Daxx.
992:
1544:. Only when Daxx was bound to Pml were apoptosis rates higher, suggesting that associated cytoplasmic Daxx has the role of an anti-apoptotic molecule.
973:
186:
2293:
1585:
1370:. Daxx serves as an H3.3 specific histone chaperone, interacting with an H3.3/H4 dimer. It interacts with a wide variety of proteins, such as
1665:
1647:
2702:
2574:
2406:
2286:
350:
65:
2079:
Li R, Pei H, Watson DK, Papas TS (2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes".
2454:
1265:
1258:
327:
1952:"PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1"
1355:
and PML-NBs (Promyelocytic
Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and
2534:
2529:
2377:
1830:
1773:"Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres"
1475:
After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (
2459:
1634:
1613:
1630:
249:
224:
1609:
166:
2511:
2259:
provides an overview of all the structure information available in the PDB for Human Death domain-associated protein 6
363:
262:
2448:
1581:
2677:
356:
255:
1347:-associated protein, was first discovered through its cytoplasmic interaction with the classical death receptor
2611:
2250:
2198:"Dualistic function of Daxx at centromeric and pericentromeric heterochromatin in normal and stress conditions"
1515:
1059:
174:
1531:
or UV-irradiation. Another study showed loss of Daxx pro-apoptotic function in case of a mutant without Pml.
2521:
2347:
1451:
1040:
1030:
1026:
1022:
1018:
1014:
2645:
1950:
Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF, Maul GG (1999).
2503:
2329:
1450:
out of the nucleus and into the cytoplasm. The breakdown of glucose produces reactive oxygen species (
1413:, which have especially high expression of the protein. At the level of the cell, Daxx is found in the
1487:, which stands for the translocation of nuclear Daxx to the cytoplasm. In turn, Daxx activates ASK1.
1784:
1561:
1541:
1454:). These induce extracellular Daxx to translocalize into the cytoplasm following an association with
238:
2038:"Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis"
153:
2312:
1499:
1241:
1233:
1208:
1204:
1200:
1174:
1166:
1141:
1137:
1133:
2246:
2184:
2104:
1565:
198:
1580:. Proteins other than transcription factors are also blocked or inhibited by Daxx, such as the
1237:
1212:
1170:
1145:
2227:
2176:
2147:
2096:
2067:
2024:
1981:
1938:
1909:
1866:
1812:
1753:
1700:
1560:
The omnipresence of Daxx in the cell nucleus suggests that the protein may also function as a
1447:
146:
58:
157:, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40
2217:
2209:
2168:
2137:
2129:
2088:
2057:
2049:
2014:
2006:
1971:
1963:
1930:
1899:
1891:
1858:
1802:
1792:
1743:
1735:
1692:
1528:
1458:(Apoptosis signal-regulating kinase1). Another mechanism for exogenous Daxx import involves
608:
601:
443:
374:
318:
273:
1719:
1511:
1352:
418:
194:
1788:
2222:
2197:
2062:
2037:
1976:
1951:
1904:
1879:
1807:
1772:
1748:
1723:
1934:
1895:
1739:
1362:
This gene encodes a multifunctional protein that resides in multiple locations in the
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
786:
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771:
766:
761:
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751:
746:
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690:
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680:
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655:
650:
2696:
2596:
2269:
2256:
2142:
2133:
2117:
2019:
1994:
637:
2188:
2108:
2010:
178:
2434:
2413:
2355:
1418:
1398:
1363:
1344:
436:
215:
1417:, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the
1995:"Sequestration and inhibition of Daxx-mediated transcriptional repression by PML"
202:
2655:
1670:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1652:
National Center for
Biotechnology Information, U.S. National Library of Medicine
519:
2337:
2278:
1862:
1503:
1435:
1390:
1356:
1348:
335:
232:
182:
2601:
1696:
2569:
2564:
2494:
2423:
2418:
2401:
2320:
2309:
1797:
1414:
1386:
1371:
1367:
937:
579:
457:
402:
389:
301:
288:
190:
2231:
2180:
2151:
2100:
2092:
2071:
2028:
1985:
1870:
1816:
1483:. Some kind of positive feedback system was also discovered; JNK activates
2053:
1967:
1942:
1913:
1757:
1704:
1547:
1409:
Daxx is uniformly expressed throughout the body, except in the testes and
1381:, and transcription factor erythroblastosis virus E26 oncogene homolog 1 (
1305:
1300:
2660:
2616:
1577:
1495:
1394:
1289:
1108:
1089:
1085:
2036:
Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP (2000).
1568:, Daxx can interact and suppress several transcription factors, such as
2213:
1374:
1325:
1071:
1004:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
41:
2606:
2591:
2476:
2172:
1410:
1378:
1273:
959:
1880:"Daxx, a novel Fas-binding protein that activates JNK and apoptosis"
1724:"Daxx, a novel Fas-binding protein that activates JNK and apoptosis"
17:
1849:
Salomoni P, Khelifi AF (2006). "Daxx: death or survival protein?".
2670:
2665:
2581:
2552:
2471:
1546:
1507:
1484:
922:
918:
2650:
2586:
2559:
2396:
2389:
2384:
2118:"Inhibition of Daxx-mediated apoptosis by heat shock protein 27"
1480:
1459:
1455:
1431:
1382:
1332:
853:
extrinsic apoptotic signaling pathway via death domain receptors
170:
2282:
617:
1573:
1569:
1476:
1993:
Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD (2000).
1771:
Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD (2010).
1506:
domain of the protein. When the cell is treated with TGF-β,
903:
positive regulation of nucleic acid-templated transcription
1588:, conferring upon Daxx a major role in TGF-β signaling.
426:
2196:
Morozov VM, Gavrilova EV, Ogryzko VV, Ishov AM (2012).
1878:
Yang X, Khosravi-Far R, Chang HY, Baltimore D (1997).
591:
2116:
Charette SJ, Lavoie JN, Lambert H, Landry J (2000).
2636:
2629:
2543:
2520:
2502:
2493:
2432:
2364:
2346:
2328:
2319:
1226:
1193:
1159:
1126:
848:
negative regulation of transcription, DNA-templated
1626:
1624:
1622:
1605:
1603:
1601:
1514:Daxx and the activated Daxx in turn activates the
373:
272:
1631:GRCm38: Ensembl release 89: ENSMUSG00000002307
858:positive regulation of protein kinase activity
818:positive regulation of protein phosphorylation
2294:
8:
2633:
2499:
2370:
2325:
2301:
2287:
2279:
2266:United States National Library of Medicine
1401:, phosphorylation and polyubiquitination.
1009:
933:
823:regulation of transcription, DNA-templated
633:
414:
313:
210:
76:
2249:at the U.S. National Library of Medicine
2221:
2141:
2061:
2018:
1975:
1903:
1806:
1796:
1747:
1518:pathway (see "The Daxx Pathway" figure).
2264:This article incorporates text from the
1446:Fas-receptor stimulation causes Daxx to
1597:
31:
378:
339:
334:
277:
236:
231:
7:
1389:. This protein also associates with
893:cellular response to sodium arsenite
828:regulation of protein ubiquitination
833:positive regulation of neuron death
803:androgen receptor signaling pathway
726:protein heterodimerization activity
2455:Bcl-2 homologous antagonist killer
1223:
1190:
1156:
1123:
1099:
1076:
1050:
983:
964:
716:transcription corepressor activity
711:transcription coactivator activity
596:
514:
452:
431:
25:
1328:that in humans is encoded by the
676:protein kinase activator activity
656:protein homodimerization activity
2535:Tumor necrosis factor receptor 2
2530:Tumor necrosis factor receptor 1
2378:Death-inducing signaling complex
2134:10.1128/MCB.20.20.7602-7612.2000
1564:. Although it contains no known
878:cellular response to cadmium ion
752:SWI/SNF superfamily-type complex
691:ubiquitin protein ligase binding
607:
600:
362:
355:
349:
326:
261:
254:
248:
223:
40:
2460:Bcl-2-associated death promoter
2011:10.1128/MCB.20.5.1784-1796.2000
908:regulation of apoptotic process
883:cellular response to copper ion
1351:. It has been associated with
767:chromosome, centromeric region
618:More reference expression data
580:More reference expression data
1:
1935:10.1016/S0378-1119(97)00411-3
1896:10.1016/S0092-8674(00)80294-9
1740:10.1016/S0092-8674(00)80294-9
347:
246:
1777:Proc. Natl. Acad. Sci. U.S.A
888:cellular response to diamide
838:transcription, DNA-templated
696:transcription factor binding
2703:Genes on human chromosome 6
2512:Tumor necrosis factor alpha
488:stromal cell of endometrium
2719:
1405:Structure and localization
1318:Death-associated protein 6
661:protein N-terminus binding
651:heat shock protein binding
2678:Apoptosis-inducing factor
2373:
1863:10.1016/j.tcb.2005.12.002
1666:"Mouse PubMed Reference:"
1648:"Human PubMed Reference:"
1304:
1299:
1295:
1288:
1272:
1253:
1230:
1197:
1186:
1163:
1130:
1119:
1106:
1102:
1083:
1079:
1070:
1057:
1053:
1038:
1012:
1003:
990:
986:
971:
967:
958:
943:
936:
932:
916:
873:Unfolded Protein Response
868:cellular response to heat
701:androgen receptor binding
636:
632:
615:
599:
590:
577:
526:
517:
464:
455:
425:
417:
413:
396:
383:
346:
325:
316:
312:
295:
282:
245:
222:
213:
209:
164:
161:
151:
144:
139:
84:
79:
62:
57:
52:
48:
39:
34:
2251:Medical Subject Headings
1718:Yang X, Khosravi-Far R,
1697:10.1089/dna.1997.16.1289
1522:Miscellaneous mechanisms
1442:Cytoplasmic and membrane
1266:Chr 17: 34.13 – 34.13 Mb
1798:10.1073/pnas.1008850107
1535:Anti-apoptotic function
1259:Chr 6: 33.32 – 33.32 Mb
558:internal carotid artery
29:Protein found in humans
2093:10.1038/sj.onc.1203385
1722:, Baltimore D (1997).
1552:
1500:TGF-β type II receptor
898:chromatin organization
706:protein kinase binding
380:17 B1|17 17.98 cM
2054:10.1084/jem.191.4.631
1968:10.1083/jcb.147.2.221
1550:
341:Chromosome 17 (mouse)
1783:(32): 140765–14080.
1562:transcription factor
1542:embryonic stem cells
1510:, a nuclear kinase,
1379:centromere protein C
808:chromatin remodeling
239:Chromosome 6 (human)
80:List of PDB id codes
53:Available structures
2247:DAXX+protein,+human
1831:"Entrez Gene: DAXX"
1789:2010PNAS..10714075L
1566:DNA-binding domains
813:nucleosome assembly
542:seminiferous tubule
2268:, which is in the
2214:10.4161/nucl.20180
1553:
1060:ENSMUSG00000002307
796:Biological process
735:Cellular component
644:Molecular function
500:left adrenal gland
2690:
2689:
2686:
2685:
2625:
2624:
2489:
2488:
2485:
2484:
2313:signaling pathway
1466:Role in apoptosis
1315:
1314:
1311:
1310:
1284:
1283:
1249:
1248:
1220:
1219:
1182:
1181:
1153:
1152:
1115:
1114:
1096:
1095:
1066:
1065:
1047:
1046:
999:
998:
980:
979:
928:
927:
863:apoptotic process
628:
627:
624:
623:
586:
585:
573:
572:
511:
510:
504:left uterine tube
409:
408:
308:
307:
135:
134:
131:
130:
63:Ortholog search:
16:(Redirected from
2710:
2634:
2500:
2371:
2326:
2303:
2296:
2289:
2280:
2235:
2225:
2192:
2173:10.1038/35087019
2155:
2145:
2112:
2075:
2065:
2032:
2022:
1989:
1979:
1946:
1917:
1907:
1874:
1851:Trends Cell Biol
1835:
1834:
1827:
1821:
1820:
1810:
1800:
1768:
1762:
1761:
1751:
1715:
1709:
1708:
1680:
1674:
1673:
1662:
1656:
1655:
1644:
1638:
1628:
1617:
1607:
1551:The DAXX Pathway
1529:oxidative stress
1297:
1296:
1268:
1261:
1244:
1224:
1215:
1191:
1187:RefSeq (protein)
1177:
1157:
1148:
1124:
1100:
1077:
1051:
1034:
1010:
984:
965:
934:
634:
620:
611:
604:
597:
582:
562:secondary oocyte
538:genital tubercle
522:
520:Top expressed in
515:
484:ventricular zone
460:
458:Top expressed in
453:
432:
415:
405:
392:
381:
366:
359:
353:
342:
330:
314:
304:
291:
280:
265:
258:
252:
241:
227:
211:
205:
203:DAXX - orthologs
156:
149:
126:
77:
71:
50:
49:
44:
32:
21:
2718:
2717:
2713:
2712:
2711:
2709:
2708:
2707:
2693:
2692:
2691:
2682:
2621:
2539:
2516:
2481:
2467:Anti-apoptotic:
2428:
2360:
2342:
2315:
2307:
2276:
2243:
2238:
2195:
2158:
2128:(20): 7602–12.
2122:Mol. Cell. Biol
2115:
2078:
2035:
1999:Mol. Cell. Biol
1992:
1949:
1929:(1–2): 149–56.
1920:
1877:
1848:
1844:
1842:Further reading
1839:
1838:
1829:
1828:
1824:
1770:
1769:
1765:
1717:
1716:
1712:
1691:(11): 1289–98.
1682:
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1663:
1659:
1646:
1645:
1641:
1629:
1620:
1608:
1599:
1594:
1558:
1556:Other functions
1537:
1524:
1493:
1491:TGF-β regulated
1473:
1468:
1444:
1427:
1407:
1353:heterochromatin
1341:
1306:View/Edit Mouse
1301:View/Edit Human
1264:
1257:
1254:Location (UCSC)
1240:
1236:
1232:
1211:
1207:
1203:
1199:
1173:
1169:
1165:
1144:
1140:
1136:
1132:
1088:
1041:ENSG00000229396
1033:
1031:ENSG00000204209
1029:
1027:ENSG00000206279
1025:
1023:ENSG00000227046
1021:
1019:ENSG00000206206
1017:
1015:ENSG00000231617
1013:
912:
791:
730:
681:protein binding
666:histone binding
616:
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317:Gene location (
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214:Gene location (
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86:
64:
30:
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22:
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2483:
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2479:
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2451:
2446:
2444:Pro-apoptotic:
2440:
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2241:External links
2239:
2237:
2236:
2193:
2161:Nat. Cell Biol
2156:
2113:
2076:
2033:
2005:(5): 1784–96.
1990:
1947:
1918:
1890:(7): 1067–76.
1875:
1845:
1843:
1840:
1837:
1836:
1822:
1763:
1734:(7): 1067–76.
1710:
1675:
1657:
1639:
1618:
1596:
1595:
1593:
1590:
1557:
1554:
1536:
1533:
1523:
1520:
1512:phosphorylates
1502:by binding of
1492:
1489:
1472:
1469:
1467:
1464:
1443:
1440:
1426:
1423:
1406:
1403:
1340:
1337:
1320:also known as
1313:
1312:
1309:
1308:
1303:
1293:
1292:
1286:
1285:
1282:
1281:
1279:
1277:
1270:
1269:
1262:
1255:
1251:
1250:
1247:
1246:
1228:
1227:
1221:
1218:
1217:
1195:
1194:
1188:
1184:
1183:
1180:
1179:
1161:
1160:
1154:
1151:
1150:
1128:
1127:
1121:
1117:
1116:
1113:
1112:
1104:
1103:
1097:
1094:
1093:
1081:
1080:
1074:
1068:
1067:
1064:
1063:
1055:
1054:
1048:
1045:
1044:
1036:
1035:
1007:
1001:
1000:
997:
996:
988:
987:
981:
978:
977:
969:
968:
962:
956:
955:
950:
945:
941:
940:
930:
929:
926:
925:
914:
913:
911:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
799:
797:
793:
792:
790:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
738:
736:
732:
731:
729:
728:
723:
718:
713:
708:
703:
698:
693:
688:
686:enzyme binding
683:
678:
673:
668:
663:
658:
653:
647:
645:
641:
640:
630:
629:
626:
625:
622:
621:
613:
612:
594:
588:
587:
584:
583:
575:
574:
571:
570:
568:
567:
563:
559:
555:
554:tail of embryo
551:
547:
543:
539:
535:
531:
527:
524:
523:
512:
509:
508:
506:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
462:
461:
449:
448:
440:
429:
423:
422:
419:RNA expression
411:
410:
407:
406:
398:
394:
393:
385:
382:
377:
371:
370:
361:
354:
348:
344:
343:
338:
332:
331:
323:
322:
310:
309:
306:
305:
297:
293:
292:
284:
281:
276:
270:
269:
260:
253:
247:
243:
242:
235:
229:
228:
220:
219:
207:
206:
163:
159:
158:
150:
142:
141:
137:
136:
133:
132:
129:
128:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2715:
2704:
2701:
2700:
2698:
2679:
2676:
2675:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2643:
2641:
2639:
2638:Intracellular
2635:
2632:
2628:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2579:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2557:
2554:
2551:
2550:
2548:
2546:
2545:Intracellular
2542:
2536:
2533:
2531:
2528:
2527:
2525:
2523:
2519:
2513:
2510:
2509:
2507:
2505:
2501:
2498:
2496:
2492:
2478:
2475:
2473:
2470:
2468:
2465:
2464:
2461:
2458:
2456:
2452:
2450:
2447:
2445:
2442:
2441:
2439:
2437:
2436:
2431:
2425:
2422:
2420:
2417:
2415:
2412:
2411:
2408:
2405:
2403:
2400:
2398:
2395:
2394:
2391:
2388:
2386:
2383:
2382:
2379:
2376:
2375:
2372:
2369:
2367:
2366:Intracellular
2363:
2357:
2354:
2353:
2351:
2349:
2345:
2339:
2336:
2335:
2333:
2331:
2327:
2324:
2322:
2318:
2314:
2311:
2304:
2299:
2297:
2292:
2290:
2285:
2284:
2281:
2277:
2274:
2273:
2271:
2270:public domain
2267:
2258:
2255:
2252:
2248:
2245:
2244:
2240:
2233:
2229:
2224:
2219:
2215:
2211:
2208:(3): 276–85.
2207:
2203:
2199:
2194:
2190:
2186:
2182:
2178:
2174:
2170:
2167:(8): 708–14.
2166:
2162:
2157:
2153:
2149:
2144:
2139:
2135:
2131:
2127:
2123:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2090:
2087:(6): 745–53.
2086:
2082:
2077:
2073:
2069:
2064:
2059:
2055:
2051:
2048:(4): 631–40.
2047:
2043:
2039:
2034:
2030:
2026:
2021:
2016:
2012:
2008:
2004:
2000:
1996:
1991:
1987:
1983:
1978:
1973:
1969:
1965:
1962:(2): 221–34.
1961:
1957:
1953:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1919:
1915:
1911:
1906:
1901:
1897:
1893:
1889:
1885:
1881:
1876:
1872:
1868:
1864:
1860:
1857:(2): 97–104.
1856:
1852:
1847:
1846:
1841:
1832:
1826:
1823:
1818:
1814:
1809:
1804:
1799:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1759:
1755:
1750:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1714:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1685:DNA Cell Biol
1679:
1676:
1671:
1667:
1661:
1658:
1653:
1649:
1643:
1640:
1636:
1632:
1627:
1625:
1623:
1619:
1615:
1611:
1606:
1604:
1602:
1598:
1591:
1589:
1587:
1583:
1582:TGF-β pathway
1579:
1575:
1571:
1567:
1563:
1555:
1549:
1545:
1543:
1534:
1532:
1530:
1521:
1519:
1517:
1513:
1509:
1505:
1501:
1497:
1490:
1488:
1486:
1482:
1478:
1470:
1465:
1463:
1461:
1457:
1453:
1449:
1441:
1439:
1437:
1433:
1424:
1422:
1420:
1416:
1412:
1404:
1402:
1400:
1396:
1392:
1388:
1384:
1380:
1376:
1373:
1369:
1365:
1360:
1358:
1354:
1350:
1346:
1338:
1336:
1334:
1331:
1327:
1323:
1319:
1307:
1302:
1298:
1294:
1291:
1287:
1280:
1278:
1275:
1271:
1267:
1263:
1260:
1256:
1252:
1245:
1243:
1239:
1235:
1229:
1225:
1222:
1216:
1214:
1210:
1206:
1202:
1196:
1192:
1189:
1185:
1178:
1176:
1172:
1168:
1162:
1158:
1155:
1149:
1147:
1143:
1139:
1135:
1129:
1125:
1122:
1120:RefSeq (mRNA)
1118:
1111:
1110:
1105:
1101:
1098:
1092:
1091:
1087:
1082:
1078:
1075:
1073:
1069:
1062:
1061:
1056:
1052:
1049:
1043:
1042:
1037:
1032:
1028:
1024:
1020:
1016:
1011:
1008:
1006:
1002:
995:
994:
989:
985:
982:
976:
975:
970:
966:
963:
961:
957:
954:
951:
949:
946:
942:
939:
935:
931:
924:
920:
915:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
843:viral process
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
800:
798:
795:
794:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
739:
737:
734:
733:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
639:
638:Gene ontology
635:
631:
619:
614:
610:
603:
598:
595:
593:
589:
581:
576:
565:
561:
557:
553:
549:
545:
541:
537:
533:
529:
528:
525:
521:
516:
513:
503:
499:
495:
491:
487:
483:
479:
475:
471:
467:
466:
463:
459:
454:
451:
450:
447:
445:
441:
439:
438:
434:
433:
430:
428:
424:
420:
416:
412:
404:
399:
395:
391:
386:
376:
372:
365:
358:
352:
345:
337:
333:
329:
324:
320:
315:
311:
303:
298:
294:
290:
285:
275:
271:
264:
257:
251:
244:
240:
234:
230:
226:
221:
217:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
160:
155:
148:
143:
138:
127:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
27:
19:
2466:
2443:
2435:Bcl-2 family
2433:
2414:Cytochrome c
2356:Fas receptor
2275:
2263:
2262:
2205:
2201:
2164:
2160:
2125:
2121:
2084:
2080:
2045:
2041:
2002:
1998:
1959:
1956:J. Cell Biol
1955:
1926:
1922:
1887:
1883:
1854:
1850:
1825:
1780:
1776:
1766:
1731:
1727:
1713:
1688:
1684:
1678:
1669:
1660:
1651:
1642:
1559:
1538:
1525:
1494:
1474:
1445:
1428:
1408:
1395:the G2 phase
1361:
1359:regulation.
1345:Death domain
1342:
1329:
1321:
1317:
1316:
1242:NP_001342633
1234:NP_001186662
1231:
1209:NP_001241646
1205:NP_001135442
1201:NP_001135441
1198:
1175:NM_001355704
1167:NM_001199733
1164:
1142:NM_001254717
1138:NM_001141970
1134:NM_001141969
1131:
1107:
1084:
1058:
1039:
991:
972:
952:
947:
787:nuclear body
721:SUMO binding
530:spermatocyte
442:
435:
162:External IDs
85:
26:
2042:J. Exp. Med
1584:regulator,
1471:Fas-induced
1448:translocate
1399:sumoylation
1391:centromeres
772:nucleoplasm
671:p53 binding
546:granulocyte
496:left testis
468:granulocyte
401:34,134,564
388:34,128,388
300:33,323,016
287:33,318,558
140:Identifiers
2338:Fas ligand
1637:, May 2017
1616:, May 2017
1592:References
1504:C-terminal
1436:interphase
1357:cell cycle
757:chromosome
472:lymph node
446:(ortholog)
183:HomoloGene
2570:Caspase 3
2565:Caspase 8
2424:Caspase 3
2419:Caspase 9
2402:Caspase 8
2310:Apoptosis
1415:cytoplasm
1372:apoptosis
1368:cytoplasm
1238:NP_031855
1213:NP_001341
1171:NM_007829
1146:NM_001350
938:Orthologs
782:cytoplasm
762:nucleolus
534:spermatid
191:GeneCards
2697:Category
2661:Survivin
2522:Receptor
2495:TNF path
2348:Receptor
2321:Fas path
2232:22572957
2189:20435808
2181:11483955
2152:11003656
2109:22299529
2101:10698492
2081:Oncogene
2072:10684855
2029:10669754
1986:10525530
1871:16406523
1817:20651253
1720:Chang HY
1633:–
1612:–
1387:nucleoli
1366:and the
1343:Daxx, a
1339:Function
1290:Wikidata
917:Sources:
747:PML body
476:appendix
2671:c-IAP-2
2666:c-IAP-1
2257:PDBe-KB
2223:3414404
2202:Nucleus
2063:2195846
1977:2174231
1943:9373149
1914:9215629
1905:2989411
1808:2922592
1785:Bibcode
1758:9215629
1749:2989411
1705:9407001
1635:Ensembl
1614:Ensembl
1425:Nuclear
1419:nucleus
1375:antigen
1364:nucleus
1326:protein
1072:UniProt
1005:Ensembl
944:Species
923:QuickGO
777:nucleus
742:cytosol
421:pattern
279:6p21.32
179:1197015
147:Aliases
2504:Ligand
2477:Bcl-xL
2330:Ligand
2253:(MeSH)
2230:
2220:
2187:
2179:
2150:
2140:
2107:
2099:
2070:
2060:
2027:
2017:
1984:
1974:
1941:
1912:
1902:
1869:
1815:
1805:
1756:
1746:
1703:
1576:, and
1411:thymus
1276:search
1274:PubMed
1109:O35613
1090:Q4VX54
1086:Q9UER7
960:Entrez
592:BioGPS
566:thymus
550:zygote
480:spleen
171:603186
2630:Other
2617:NF-κB
2592:MEKK1
2587:ASK-1
2582:TRAF2
2553:TRADD
2472:Bcl-2
2453:BAK1/
2185:S2CID
2143:86317
2105:S2CID
2020:85360
1586:Smad4
1578:NF-κB
1508:HIPK2
1496:TGF-β
1485:HIPK2
1377:Fas,
1324:is a
993:13163
953:Mouse
948:Human
919:Amigo
492:blood
444:Mouse
437:Human
384:Start
319:Mouse
283:Start
216:Human
2656:NAIP
2651:XIAP
2646:IAPs
2607:MKK7
2602:IκBα
2560:FADD
2397:FADD
2390:ASK1
2385:DAXX
2228:PMID
2177:PMID
2148:PMID
2097:PMID
2068:PMID
2025:PMID
1982:PMID
1939:PMID
1923:Gene
1910:PMID
1884:Cell
1867:PMID
1813:PMID
1754:PMID
1728:Cell
1701:PMID
1481:ASK1
1460:CRM1
1456:ASK1
1432:ATRX
1383:ETS1
1333:gene
1330:DAXX
1322:Daxx
974:1616
427:Bgee
375:Band
336:Chr.
274:Band
233:Chr.
195:DAXX
187:1033
167:OMIM
154:DAXX
124:4H9S
120:4H9R
116:4H9Q
112:4H9P
108:4H9O
104:4H9N
100:2KZU
96:2KZS
92:2KQS
88:4HGA
69:RCSB
66:PDBe
35:DAXX
18:DAXX
2612:JNK
2597:IKK
2575:BID
2449:BAX
2407:BID
2218:PMC
2210:doi
2169:doi
2138:PMC
2130:doi
2089:doi
2058:PMC
2050:doi
2046:191
2015:PMC
2007:doi
1972:PMC
1964:doi
1960:147
1931:doi
1927:200
1900:PMC
1892:doi
1859:doi
1803:PMC
1793:doi
1781:107
1744:PMC
1736:doi
1693:doi
1574:p73
1570:p53
1516:JNK
1477:JNK
1452:ROS
1393:in
1349:Fas
397:End
296:End
199:OMA
175:MGI
59:PDB
2699::
2226:.
2216:.
2204:.
2200:.
2183:.
2175:.
2163:.
2146:.
2136:.
2126:20
2124:.
2120:.
2103:.
2095:.
2085:19
2083:.
2066:.
2056:.
2044:.
2040:.
2023:.
2013:.
2003:20
2001:.
1997:.
1980:.
1970:.
1958:.
1954:.
1937:.
1925:.
1908:.
1898:.
1888:89
1886:.
1882:.
1865:.
1855:16
1853:.
1811:.
1801:.
1791:.
1779:.
1775:.
1752:.
1742:.
1732:89
1730:.
1726:.
1699:.
1689:16
1687:.
1668:.
1650:.
1621:^
1600:^
1572:,
1335:.
921:/
403:bp
390:bp
302:bp
289:bp
197:;
193::
189:;
185::
181:;
177::
173:;
169::
122:,
118:,
114:,
110:,
106:,
102:,
98:,
94:,
90:,
2302:e
2295:t
2288:v
2272:.
2234:.
2212::
2206:3
2191:.
2171::
2165:3
2154:.
2132::
2111:.
2091::
2074:.
2052::
2031:.
2009::
1988:.
1966::
1945:.
1933::
1916:.
1894::
1873:.
1861::
1833:.
1819:.
1795::
1787::
1760:.
1738::
1707:.
1695::
1672:.
1654:.
321:)
218:)
201::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
