336:
313:
210:
235:
5653:
601:
594:
587:
342:
241:
5633:
1395:(RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of
1413:
protein. In situ studies and
Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast,
57:
1799:
Perez JL, Shen X, Finkernagel S, Sciorra L, Jenkins NA, Gilbert DJ, Copeland NG, Wong TW (Jan 1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain".
1448:
ENSG00000137332, ENSG00000229767, ENSG00000230456, ENSG00000234078, ENSG00000204580, ENSG00000223680 GRCh38: Ensembl release 89: ENSG00000215522, ENSG00000137332, ENSG00000229767, ENSG00000230456, ENSG00000234078, ENSG00000204580,
1690:
Laval S, Butler R, Shelling AN, Hanby AM, Poulsom R, Ganesan TS (Nov 1994). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line".
3187:
2222:
Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB (Dec 2000). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors".
2326:
1653:
Weiner TM, Liu ET, Craven RJ, Cance WG (Jan 1994). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors".
1756:"Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues"
349:
248:
5694:
3177:
4778:
1409:
I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the
1624:
Shelling AN, Butler R, Jones T, Laval S, Boyle JM, Ganesan TS (Jan 1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16".
54:
5202:
4363:
3157:
2291:
1595:
Edelhoff S, Sweetser DA, Disteche CM (Jan 1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C".
984:
171:
4019:
2343:
2319:
965:
5075:
1874:
Perez JL, Jing SQ, Wong TW (Apr 1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines".
4501:
3750:
2259:
Mohan RR, Mohan RR, Wilson SE (Jan 2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea".
4816:
3738:
3516:
1410:
4458:
3802:
3797:
3743:
3523:
2304:
1504:
2109:
Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (Dec 1997).
5718:
5713:
4486:
3256:
3182:
2312:
1486:
335:
5687:
4854:
4845:
4545:
4540:
4535:
4530:
4285:
4280:
4275:
4270:
3197:
1539:
Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (Mar 2013).
1895:
Valent A, Meddeb M, Danglot G, Duverger A, Nguyen VC, Bernheim A (Jul 1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21".
5723:
4739:
4730:
2181:"Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors"
2010:
Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer".
1313:
1306:
312:
5352:
4521:
4250:
4424:
3486:
1525:
5728:
4054:
3548:
3234:
1473:
1452:
5680:
4356:
3693:
3229:
5508:
1469:
234:
209:
4569:
4190:
3662:
3657:
3602:
3336:
2785:
1447:
5623:
5000:
4932:
4923:
3884:
3607:
151:
5306:
5297:
5233:
5061:
3202:
5277:
348:
247:
4744:
3914:
2339:
1377:
5493:
5609:
5596:
5583:
5570:
5557:
5544:
5531:
4349:
2780:
341:
240:
142:, CAK, CD167, DDR, EHGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, discoidin domain receptor tyrosine kinase 1
5503:
5457:
5400:
4394:
4380:
3964:
2859:
1401:
1392:
1055:
159:
5405:
5118:
5109:
3928:
1419:
1036:
1032:
1022:
1018:
1014:
1010:
1006:
4407:
3271:
3266:
3261:
3251:
2558:
2486:
1823:"A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain"
5426:
5345:
5070:
4754:
2615:
2533:
5498:
2039:
Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M (Mar 1998).
3852:
3565:
1834:
1423:
1252:
223:
138:
5462:
4768:
3879:
3698:
1281:
1277:
1236:
1226:
1222:
1218:
1214:
1210:
1182:
1178:
1145:
1135:
1131:
1127:
1123:
1119:
2179:
Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA (May 2000).
1256:
5395:
5152:
5142:
5133:
4961:
4952:
3286:
3020:
2247:
2210:
2111:"An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors"
1998:
1967:
Sakuma S, Saya H, Tada M, Nakao M, Fujiwara T, Roth JA, Sawamura Y, Shinohe Y, Abe H (Dec 1996).
1920:
1678:
1399:. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the
183:
4341:
1289:
1285:
1248:
1244:
1240:
1190:
1186:
1157:
1153:
1149:
5186:
2276:
2239:
2202:
2167:
2132:
2097:
2062:
2027:
1990:
1955:
1912:
1883:
1862:
1809:
1787:
1742:
1699:
1670:
1641:
1612:
1572:
131:
47:
5664:
1541:"Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling"
5660:
5652:
5441:
5436:
5410:
5338:
4463:
4449:
4059:
3792:
3713:
3276:
2469:
2395:
2268:
2231:
2192:
2157:
2122:
2087:
2052:
2019:
1980:
1945:
1904:
1852:
1842:
1777:
1767:
1732:
1724:
1662:
1633:
1604:
1562:
1552:
1406:
600:
593:
428:
359:
303:
258:
4710:
5488:
5472:
5385:
5051:
4720:
4705:
4695:
4690:
4670:
4665:
4660:
4655:
4650:
4641:
4376:
4119:
2655:
2650:
2573:
586:
403:
179:
1418:, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several
2041:"Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid"
1838:
5637:
5526:
5467:
5181:
5176:
5171:
4555:
4372:
3904:
3326:
2837:
2640:
1567:
1540:
2127:
2110:
2092:
2075:
1985:
1968:
1772:
1755:
1737:
1712:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
748:
743:
738:
733:
728:
723:
718:
713:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
5707:
5431:
5390:
4617:
4478:
3874:
3331:
2422:
2295:
2235:
1857:
1822:
1637:
1608:
629:
2214:
5380:
5162:
4873:
4864:
4608:
4230:
3538:
3528:
3059:
3025:
2251:
2002:
1924:
1682:
421:
200:
163:
187:
5604:
5539:
5375:
4240:
3889:
3667:
3642:
3341:
2963:
2889:
2363:
1509:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1491:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5632:
1827:
Proceedings of the
National Academy of Sciences of the United States of America
504:
5287:
5282:
5272:
5267:
5258:
5207:
5123:
5013:
4170:
3894:
3575:
3316:
3192:
2825:
2820:
2815:
2670:
2454:
320:
217:
167:
5578:
5552:
4009:
4004:
3999:
3989:
3984:
3979:
3974:
2197:
2180:
2146:"Discoidin domain receptor 1 is activated independently of beta(1) integrin"
2144:
Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T (Feb 2000).
2057:
2040:
1932:
Playford MP, Butler RJ, Wang XC, Katso RM, Cooke IE, Ganesan TS (Jul 1996).
1847:
1713:"Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase"
1557:
1415:
929:
564:
442:
387:
374:
286:
273:
175:
20:
2280:
2272:
2243:
2206:
2171:
2162:
2145:
1576:
2136:
2101:
2076:"The discoidin domain receptor tyrosine kinases are activated by collagen"
2066:
2031:
1994:
1959:
1916:
1908:
1887:
1866:
1813:
1791:
1746:
1728:
1703:
1674:
1645:
1616:
1353:
1348:
5022:
4429:
4315:
4215:
4029:
4014:
3217:
3212:
3120:
2810:
1396:
1337:
1100:
1081:
1782:
4265:
4260:
4255:
4155:
3969:
3959:
3786:
3765:
3760:
3728:
3533:
3453:
3448:
3443:
3438:
3433:
3351:
3044:
2884:
2879:
2874:
2869:
2864:
2335:
1950:
1933:
1666:
1067:
996:
2023:
697:
108:
104:
100:
96:
92:
88:
84:
80:
76:
5591:
5361:
5311:
4574:
4510:
4505:
4205:
4165:
4150:
4134:
4129:
4109:
4104:
4039:
3847:
3817:
3781:
3772:
3585:
3553:
3417:
3412:
3382:
3361:
3321:
3281:
3147:
3125:
3084:
3008:
3003:
2998:
2993:
2988:
2983:
2852:
2847:
2842:
2790:
2775:
2645:
2635:
2598:
2593:
2511:
2506:
1969:"Receptor protein tyrosine kinase DDR is up-regulated by p53 protein"
1321:
951:
5565:
5099:
4977:
4942:
4937:
4913:
4715:
4700:
4685:
4680:
4675:
4627:
4622:
4598:
4593:
4584:
4496:
4491:
4468:
4439:
4434:
4330:
4305:
4225:
4220:
4210:
4200:
4185:
4180:
4175:
4160:
4114:
4099:
4064:
4049:
4044:
4034:
3954:
3949:
3944:
3923:
3919:
3909:
3822:
3723:
3718:
3677:
3627:
3622:
3617:
3612:
3597:
3590:
3570:
3558:
3501:
3496:
3491:
3481:
3476:
3469:
3407:
3397:
3392:
3387:
3377:
3356:
3346:
3311:
3306:
3301:
3296:
3291:
3246:
3241:
3207:
3172:
3167:
3162:
3152:
3140:
3135:
3115:
3110:
3105:
3100:
3054:
2946:
2941:
2760:
2744:
2737:
2732:
2727:
2722:
2717:
2712:
2687:
2665:
2660:
2553:
2479:
2474:
2464:
1754:
Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M (Nov 1993).
914:
910:
5217:
5147:
5094:
5085:
5046:
5037:
5027:
4908:
4899:
4889:
4835:
4826:
4792:
4787:
4763:
4564:
4416:
4325:
4320:
4310:
4300:
4295:
4290:
4245:
4235:
4195:
4124:
4094:
4089:
4084:
4079:
4074:
4069:
4024:
3994:
3899:
3867:
3862:
3842:
3832:
3827:
3812:
3807:
3708:
3703:
3672:
3652:
3647:
3637:
3632:
3464:
3424:
3079:
3074:
3069:
3064:
3049:
3040:
3035:
3030:
3015:
2973:
2968:
2958:
2953:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2832:
2805:
2800:
2795:
2770:
2765:
2702:
2697:
2692:
2682:
2677:
2630:
2625:
2620:
2610:
2605:
2588:
2583:
2578:
2568:
2563:
2548:
2543:
2538:
2528:
2523:
2518:
2501:
2496:
2491:
2442:
2410:
2405:
2400:
2383:
2378:
2373:
2368:
1381:
780:
transmembrane receptor protein tyrosine kinase signaling pathway
155:
5334:
4998:
4392:
4345:
2308:
5248:
5243:
5238:
5212:
3837:
2449:
2437:
2432:
2427:
2417:
2390:
2358:
1526:"Entrez Gene: DDR1 discoidin domain receptor family, member 1"
609:
1934:"The genomic structure of discoidin receptor tyrosine kinase"
765:
collagen-activated tyrosine kinase receptor signaling pathway
5330:
411:
5668:
678:
transmembrane receptor protein tyrosine kinase activity
1426:
of this gene results in multiple transcript variants.
770:
branching involved in mammary gland duct morphogenesis
5621:
576:
1711:
Kato JY, Matsuoka M, Strom DK, Sherr CJ (Apr 1994).
890:
positive regulation of cell population proliferation
860:
negative regulation of cell population proliferation
5517:
5481:
5450:
5419:
5368:
5296:
5257:
5226:
5195:
5161:
5132:
5108:
5084:
5060:
5036:
5012:
4970:
4951:
4922:
4898:
4882:
4863:
4844:
4825:
4801:
4777:
4753:
4729:
4640:
4607:
4583:
4554:
4520:
4477:
4448:
4415:
4406:
4143:
3937:
3686:
3370:
3093:
2753:
2351:
1270:
1209:
1171:
1118:
1465:
1463:
1461:
1443:
1441:
1439:
683:protein tyrosine kinase collagen receptor activity
358:
257:
2074:Vogel W, Gish GD, Alves F, Pawson T (Dec 1997).
900:regulation of extracellular matrix organization
16:Protein-coding gene in the species Homo sapiens
1470:GRCm38: Ensembl release 89: ENSMUSG00000003534
805:regulation of extracellular matrix disassembly
5688:
5346:
4357:
2320:
8:
1821:Johnson JD, Edman JC, Rutter WJ (Jun 1993).
5695:
5681:
5353:
5339:
5331:
5009:
4995:
4412:
4403:
4389:
4364:
4350:
4342:
2327:
2313:
2305:
2292:United States National Library of Medicine
1366:Discoidin domain receptor family, member 1
1206:
1115:
1001:
925:
625:
399:
298:
195:
65:
2344:list of human clusters of differentiation
2196:
2161:
2126:
2091:
2056:
1984:
1949:
1856:
1846:
1781:
1771:
1736:
1566:
1556:
2290:This article incorporates text from the
1520:
1518:
5628:
1435:
25:
865:peptidyl-tyrosine autophosphorylation
734:integral component of plasma membrane
363:
324:
319:
262:
221:
216:
19:For the type of computer memory, see
7:
5649:
5647:
2150:The Journal of Biological Chemistry
1760:The Journal of Biological Chemistry
1545:The Journal of Biological Chemistry
5667:. You can help Knowledge (XXG) by
1267:
1168:
1091:
1072:
1046:
975:
956:
820:regulation of cell-matrix adhesion
815:smooth muscle cell-matrix adhesion
800:mammary gland alveolus development
581:
499:
437:
416:
14:
1692:Cell Growth & Differentiation
850:wound healing, spreading of cells
840:peptidyl-tyrosine phosphorylation
790:extracellular matrix organization
5651:
5631:
2236:10.1097/00006123-200012000-00028
688:protein tyrosine kinase activity
599:
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
1717:Molecular and Cellular Biology
714:integral component of membrane
610:More reference expression data
565:More reference expression data
465:olfactory zone of nasal mucosa
1:
5001:Non-receptor tyrosine kinases
2128:10.1016/S1097-2765(00)80004-0
2093:10.1016/S1097-2765(00)80003-9
1986:10.1016/S0014-5793(96)01234-3
1773:10.1016/S0021-9258(20)80524-9
332:
231:
1638:10.1016/0888-7543(95)80065-T
1609:10.1016/0888-7543(95)80144-B
810:smooth muscle cell migration
523:Epithelium of choroid plexus
5719:Clusters of differentiation
5714:Genes on human chromosome 6
2340:clusters of differentiation
1655:Annals of Surgical Oncology
880:neuron projection extension
870:protein autophosphorylation
5745:
5646:
1378:cluster of differentiation
539:medial ganglionic eminence
527:retinal pigment epithelium
18:
5724:Tyrosine kinase receptors
5509:Michaelis–Menten kinetics
5008:
4994:
4402:
4395:Receptor tyrosine kinases
4388:
2261:Experimental Eye Research
1505:"Mouse PubMed Reference:"
1487:"Human PubMed Reference:"
1393:Receptor tyrosine kinases
1352:
1347:
1343:
1336:
1320:
1301:
1274:
1233:
1202:
1175:
1142:
1111:
1098:
1094:
1079:
1075:
1066:
1053:
1049:
1030:
1004:
995:
982:
978:
963:
959:
950:
935:
928:
924:
908:
835:regulation of cell growth
628:
624:
607:
584:
575:
562:
511:
502:
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
73:
68:
51:
46:
41:
37:
33:
28:
5401:Diffusion-limited enzyme
1402:Dictyostelium discoideum
1314:Chr 17: 35.99 – 36.02 Mb
698:receptor tyrosine kinase
535:Rostral migratory stream
4408:Growth factor receptors
2198:10.1096/fasebj.14.7.973
2058:10.1210/endo.139.3.5791
1848:10.1073/pnas.90.12.5677
1558:10.1074/jbc.R112.444158
825:protein phosphorylation
653:protein kinase activity
5729:Membrane protein stubs
5663:–related article is a
2273:10.1006/exer.2000.0932
2163:10.1074/jbc.275.8.5779
1307:Chr 6: 30.88 – 30.9 Mb
5494:Eadie–Hofstee diagram
5427:Allosteric regulation
1909:10.1007/s004390050152
1729:10.1128/MCB.14.4.2713
744:extracellular exosome
543:epithelium of stomach
473:minor salivary glands
365:17 B1|17 18.7 cM
326:Chromosome 17 (mouse)
5504:Lineweaver–Burk plot
4479:PDGF receptor family
1424:Alternative splicing
895:cell differentiation
885:cell-matrix adhesion
739:extracellular region
643:transferase activity
224:Chromosome 6 (human)
69:List of PDB id codes
42:Available structures
4883:ROS receptor family
4417:EGF receptor family
1839:1993PNAS...90.5677J
855:embryo implantation
749:extracellular space
531:conjunctival fornix
485:mucosa of esophagus
477:islet of Langerhans
461:ganglionic eminence
5463:Enzyme superfamily
5396:Enzyme promiscuity
2294:, which is in the
1951:10.1101/gr.6.7.620
1667:10.1007/BF02303537
1380:167a), is a human
1056:ENSMUSG00000003534
758:Biological process
707:Cellular component
648:nucleotide binding
636:Molecular function
457:right uterine tube
5676:
5675:
5619:
5618:
5328:
5327:
5324:
5323:
5320:
5319:
4990:
4989:
4986:
4985:
4636:
4635:
4339:
4338:
2024:10.1159/000164123
1363:
1362:
1359:
1358:
1332:
1331:
1297:
1296:
1264:
1263:
1198:
1197:
1165:
1164:
1107:
1106:
1088:
1087:
1062:
1061:
1043:
1042:
991:
990:
972:
971:
920:
919:
663:metal ion binding
620:
619:
616:
615:
571:
570:
558:
557:
496:
495:
394:
393:
293:
292:
120:
119:
116:
115:
52:Ortholog search:
5736:
5697:
5690:
5683:
5661:membrane protein
5655:
5648:
5636:
5635:
5627:
5499:Hanes–Woolf plot
5442:Enzyme activator
5437:Enzyme inhibitor
5411:Enzyme catalysis
5355:
5348:
5341:
5332:
5010:
4996:
4450:Insulin receptor
4413:
4404:
4390:
4377:tyrosine kinases
4366:
4359:
4352:
4343:
2329:
2322:
2315:
2306:
2284:
2255:
2218:
2200:
2175:
2165:
2140:
2130:
2105:
2095:
2070:
2060:
2035:
2006:
1988:
1963:
1953:
1928:
1891:
1870:
1860:
1850:
1817:
1795:
1785:
1775:
1750:
1740:
1707:
1686:
1649:
1620:
1581:
1580:
1570:
1560:
1536:
1530:
1529:
1522:
1513:
1512:
1501:
1495:
1494:
1483:
1477:
1467:
1456:
1445:
1368:, also known as
1345:
1344:
1316:
1309:
1292:
1268:
1259:
1207:
1203:RefSeq (protein)
1193:
1169:
1160:
1116:
1092:
1073:
1047:
1026:
1002:
976:
957:
926:
875:axon development
785:female pregnancy
724:receptor complex
658:collagen binding
626:
612:
603:
596:
589:
582:
567:
507:
505:Top expressed in
500:
489:substantia nigra
453:ventricular zone
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
188:DDR1 - orthologs
141:
134:
111:
66:
60:
39:
38:
26:
5744:
5743:
5739:
5738:
5737:
5735:
5734:
5733:
5704:
5703:
5702:
5701:
5644:
5642:
5630:
5622:
5620:
5615:
5527:Oxidoreductases
5513:
5489:Enzyme kinetics
5477:
5473:List of enzymes
5446:
5415:
5386:Catalytic triad
5364:
5359:
5329:
5316:
5292:
5253:
5222:
5191:
5157:
5128:
5104:
5080:
5056:
5032:
5004:
4982:
4966:
4947:
4918:
4894:
4878:
4859:
4840:
4821:
4797:
4773:
4749:
4725:
4632:
4603:
4579:
4550:
4516:
4473:
4444:
4398:
4384:
4373:Protein kinases
4370:
4340:
4335:
4139:
3933:
3682:
3366:
3089:
2749:
2347:
2333:
2302:
2287:
2258:
2221:
2178:
2143:
2108:
2073:
2038:
2009:
1966:
1938:Genome Research
1931:
1894:
1873:
1833:(12): 5677–81.
1820:
1798:
1766:(32): 24290–5.
1753:
1710:
1698:(11): 1173–83.
1689:
1652:
1623:
1594:
1590:
1588:Further reading
1585:
1584:
1538:
1537:
1533:
1524:
1523:
1516:
1503:
1502:
1498:
1485:
1484:
1480:
1468:
1459:
1449:ENSG00000223680
1446:
1437:
1432:
1390:
1354:View/Edit Mouse
1349:View/Edit Human
1312:
1305:
1302:Location (UCSC)
1288:
1284:
1280:
1276:
1255:
1251:
1247:
1243:
1239:
1235:
1229:
1225:
1221:
1217:
1213:
1189:
1185:
1181:
1177:
1156:
1152:
1148:
1144:
1138:
1134:
1130:
1126:
1122:
1037:ENSG00000223680
1035:
1033:ENSG00000204580
1025:
1023:ENSG00000234078
1021:
1019:ENSG00000230456
1017:
1015:ENSG00000229767
1013:
1011:ENSG00000137332
1009:
1007:ENSG00000215522
1005:
904:
795:ear development
775:phosphorylation
753:
729:plasma membrane
702:
673:protein binding
668:kinase activity
608:
598:
597:
591:
590:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
481:skin of abdomen
479:
475:
471:
467:
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
75:
53:
24:
17:
12:
11:
5:
5742:
5740:
5732:
5731:
5726:
5721:
5716:
5706:
5705:
5700:
5699:
5692:
5685:
5677:
5674:
5673:
5656:
5641:
5640:
5617:
5616:
5614:
5613:
5600:
5587:
5574:
5561:
5548:
5535:
5521:
5519:
5515:
5514:
5512:
5511:
5506:
5501:
5496:
5491:
5485:
5483:
5479:
5478:
5476:
5475:
5470:
5465:
5460:
5454:
5452:
5451:Classification
5448:
5447:
5445:
5444:
5439:
5434:
5429:
5423:
5421:
5417:
5416:
5414:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5378:
5372:
5370:
5366:
5365:
5360:
5358:
5357:
5350:
5343:
5335:
5326:
5325:
5322:
5321:
5318:
5317:
5315:
5314:
5309:
5303:
5301:
5294:
5293:
5291:
5290:
5285:
5280:
5275:
5270:
5264:
5262:
5255:
5254:
5252:
5251:
5246:
5241:
5236:
5230:
5228:
5224:
5223:
5221:
5220:
5215:
5210:
5205:
5199:
5197:
5193:
5192:
5190:
5189:
5184:
5179:
5174:
5168:
5166:
5159:
5158:
5156:
5155:
5150:
5145:
5139:
5137:
5130:
5129:
5127:
5126:
5121:
5115:
5113:
5106:
5105:
5103:
5102:
5097:
5091:
5089:
5082:
5081:
5079:
5078:
5073:
5067:
5065:
5058:
5057:
5055:
5054:
5049:
5043:
5041:
5034:
5033:
5031:
5030:
5025:
5019:
5017:
5006:
5005:
4999:
4992:
4991:
4988:
4987:
4984:
4983:
4981:
4980:
4974:
4972:
4968:
4967:
4965:
4964:
4958:
4956:
4949:
4948:
4946:
4945:
4940:
4935:
4929:
4927:
4920:
4919:
4917:
4916:
4911:
4905:
4903:
4900:AATYK receptor
4896:
4895:
4893:
4892:
4886:
4884:
4880:
4879:
4877:
4876:
4870:
4868:
4861:
4860:
4858:
4857:
4851:
4849:
4842:
4841:
4839:
4838:
4832:
4830:
4823:
4822:
4820:
4819:
4814:
4808:
4806:
4799:
4798:
4796:
4795:
4790:
4784:
4782:
4775:
4774:
4772:
4771:
4766:
4760:
4758:
4751:
4750:
4748:
4747:
4742:
4736:
4734:
4727:
4726:
4724:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4647:
4645:
4638:
4637:
4634:
4633:
4631:
4630:
4625:
4620:
4614:
4612:
4605:
4604:
4602:
4601:
4596:
4590:
4588:
4581:
4580:
4578:
4577:
4572:
4567:
4561:
4559:
4556:VEGF receptors
4552:
4551:
4549:
4548:
4543:
4538:
4533:
4527:
4525:
4518:
4517:
4515:
4514:
4508:
4499:
4494:
4489:
4483:
4481:
4475:
4474:
4472:
4471:
4466:
4461:
4455:
4453:
4446:
4445:
4443:
4442:
4437:
4432:
4427:
4421:
4419:
4410:
4400:
4399:
4393:
4386:
4385:
4371:
4369:
4368:
4361:
4354:
4346:
4337:
4336:
4334:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4243:
4238:
4233:
4228:
4223:
4218:
4213:
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4153:
4147:
4145:
4141:
4140:
4138:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3941:
3939:
3935:
3934:
3932:
3931:
3926:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3871:
3870:
3865:
3855:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3815:
3810:
3805:
3800:
3795:
3790:
3784:
3775:
3770:
3769:
3768:
3763:
3753:
3748:
3747:
3746:
3741:
3731:
3726:
3721:
3716:
3711:
3706:
3701:
3696:
3690:
3688:
3684:
3683:
3681:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3600:
3595:
3594:
3593:
3588:
3578:
3573:
3568:
3563:
3562:
3561:
3556:
3551:
3541:
3536:
3531:
3526:
3521:
3520:
3519:
3514:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3473:
3472:
3467:
3457:
3451:
3446:
3441:
3436:
3427:
3422:
3421:
3420:
3415:
3410:
3400:
3395:
3390:
3385:
3380:
3374:
3372:
3368:
3367:
3365:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3289:
3284:
3279:
3274:
3269:
3264:
3259:
3254:
3249:
3244:
3239:
3238:
3237:
3232:
3222:
3221:
3220:
3215:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3144:
3143:
3138:
3128:
3123:
3118:
3113:
3108:
3103:
3097:
3095:
3091:
3090:
3088:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3052:
3047:
3038:
3033:
3028:
3023:
3018:
3013:
3012:
3011:
3006:
3001:
2996:
2991:
2986:
2976:
2971:
2966:
2961:
2956:
2951:
2950:
2949:
2944:
2934:
2929:
2924:
2919:
2914:
2909:
2904:
2899:
2894:
2893:
2892:
2887:
2882:
2877:
2872:
2867:
2857:
2856:
2855:
2850:
2845:
2835:
2830:
2829:
2828:
2823:
2818:
2808:
2803:
2798:
2793:
2788:
2783:
2778:
2773:
2768:
2763:
2757:
2755:
2751:
2750:
2748:
2747:
2742:
2741:
2740:
2735:
2730:
2725:
2720:
2715:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2674:
2673:
2668:
2663:
2658:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2602:
2601:
2596:
2586:
2581:
2576:
2571:
2566:
2561:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2515:
2514:
2509:
2499:
2494:
2489:
2484:
2483:
2482:
2477:
2472:
2467:
2457:
2452:
2447:
2446:
2445:
2435:
2430:
2425:
2420:
2415:
2414:
2413:
2408:
2403:
2393:
2388:
2387:
2386:
2381:
2376:
2371:
2366:
2355:
2353:
2349:
2348:
2334:
2332:
2331:
2324:
2317:
2309:
2286:
2285:
2256:
2219:
2176:
2156:(8): 5779–84.
2141:
2115:Molecular Cell
2106:
2080:Molecular Cell
2071:
2036:
2018:(4): 195–203.
2007:
1979:(2–3): 165–9.
1964:
1929:
1897:Human Genetics
1892:
1882:(7): 1469–77.
1871:
1818:
1796:
1751:
1723:(4): 2713–21.
1708:
1687:
1650:
1621:
1591:
1589:
1586:
1583:
1582:
1551:(11): 7430–7.
1531:
1514:
1496:
1478:
1457:
1434:
1433:
1431:
1428:
1389:
1386:
1361:
1360:
1357:
1356:
1351:
1341:
1340:
1334:
1333:
1330:
1329:
1327:
1325:
1318:
1317:
1310:
1303:
1299:
1298:
1295:
1294:
1272:
1271:
1265:
1262:
1261:
1253:NP_001284583.1
1231:
1230:
1204:
1200:
1199:
1196:
1195:
1173:
1172:
1166:
1163:
1162:
1140:
1139:
1113:
1109:
1108:
1105:
1104:
1096:
1095:
1089:
1086:
1085:
1077:
1076:
1070:
1064:
1063:
1060:
1059:
1051:
1050:
1044:
1041:
1040:
1028:
1027:
999:
993:
992:
989:
988:
980:
979:
973:
970:
969:
961:
960:
954:
948:
947:
942:
937:
933:
932:
922:
921:
918:
917:
906:
905:
903:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
761:
759:
755:
754:
752:
751:
746:
741:
736:
731:
726:
721:
716:
710:
708:
704:
703:
701:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
639:
637:
633:
632:
622:
621:
618:
617:
614:
613:
605:
604:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
71:
70:
62:
61:
50:
44:
43:
35:
34:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
5741:
5730:
5727:
5725:
5722:
5720:
5717:
5715:
5712:
5711:
5709:
5698:
5693:
5691:
5686:
5684:
5679:
5678:
5672:
5670:
5666:
5662:
5657:
5654:
5650:
5645:
5639:
5634:
5629:
5625:
5611:
5607:
5606:
5601:
5598:
5594:
5593:
5588:
5585:
5581:
5580:
5575:
5572:
5568:
5567:
5562:
5559:
5555:
5554:
5549:
5546:
5542:
5541:
5536:
5533:
5529:
5528:
5523:
5522:
5520:
5516:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5486:
5484:
5480:
5474:
5471:
5469:
5468:Enzyme family
5466:
5464:
5461:
5459:
5456:
5455:
5453:
5449:
5443:
5440:
5438:
5435:
5433:
5432:Cooperativity
5430:
5428:
5425:
5424:
5422:
5418:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5391:Oxyanion hole
5389:
5387:
5384:
5382:
5379:
5377:
5374:
5373:
5371:
5367:
5363:
5356:
5351:
5349:
5344:
5342:
5337:
5336:
5333:
5313:
5310:
5308:
5305:
5304:
5302:
5299:
5295:
5289:
5286:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5265:
5263:
5260:
5256:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5231:
5229:
5225:
5219:
5216:
5214:
5211:
5209:
5206:
5204:
5201:
5200:
5198:
5194:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5169:
5167:
5164:
5160:
5154:
5151:
5149:
5146:
5144:
5141:
5140:
5138:
5135:
5131:
5125:
5122:
5120:
5117:
5116:
5114:
5111:
5107:
5101:
5098:
5096:
5093:
5092:
5090:
5087:
5083:
5077:
5074:
5072:
5069:
5068:
5066:
5063:
5059:
5053:
5050:
5048:
5045:
5044:
5042:
5039:
5035:
5029:
5026:
5024:
5021:
5020:
5018:
5015:
5011:
5007:
5003:(EC 2.7.10.2)
5002:
4997:
4993:
4979:
4976:
4975:
4973:
4971:uncategorised
4969:
4963:
4960:
4959:
4957:
4954:
4950:
4944:
4941:
4939:
4936:
4934:
4931:
4930:
4928:
4925:
4921:
4915:
4912:
4910:
4907:
4906:
4904:
4901:
4897:
4891:
4888:
4887:
4885:
4881:
4875:
4872:
4871:
4869:
4866:
4865:MuSK receptor
4862:
4856:
4853:
4852:
4850:
4847:
4843:
4837:
4834:
4833:
4831:
4828:
4827:PTK7 receptor
4824:
4818:
4815:
4813:
4810:
4809:
4807:
4804:
4800:
4794:
4791:
4789:
4786:
4785:
4783:
4780:
4776:
4770:
4767:
4765:
4762:
4761:
4759:
4756:
4752:
4746:
4743:
4741:
4738:
4737:
4735:
4732:
4728:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4648:
4646:
4643:
4639:
4629:
4626:
4624:
4621:
4619:
4616:
4615:
4613:
4610:
4606:
4600:
4597:
4595:
4592:
4591:
4589:
4586:
4582:
4576:
4573:
4571:
4568:
4566:
4563:
4562:
4560:
4557:
4553:
4547:
4544:
4542:
4539:
4537:
4534:
4532:
4529:
4528:
4526:
4523:
4519:
4512:
4509:
4507:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4484:
4482:
4480:
4476:
4470:
4467:
4465:
4462:
4460:
4457:
4456:
4454:
4451:
4447:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4422:
4420:
4418:
4414:
4411:
4409:
4405:
4401:
4397:(EC 2.7.10.1)
4396:
4391:
4387:
4382:
4378:
4374:
4367:
4362:
4360:
4355:
4353:
4348:
4347:
4344:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4232:
4229:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4148:
4146:
4142:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3940:
3936:
3930:
3927:
3925:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3869:
3866:
3864:
3861:
3860:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3804:
3801:
3799:
3796:
3794:
3791:
3788:
3785:
3783:
3779:
3776:
3774:
3771:
3767:
3764:
3762:
3759:
3758:
3757:
3754:
3752:
3749:
3745:
3742:
3740:
3737:
3736:
3735:
3732:
3730:
3727:
3725:
3722:
3720:
3717:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3691:
3689:
3685:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3592:
3589:
3587:
3584:
3583:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3560:
3557:
3555:
3552:
3550:
3547:
3546:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3518:
3515:
3513:
3510:
3509:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3471:
3468:
3466:
3463:
3462:
3461:
3458:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3431:
3428:
3426:
3423:
3419:
3416:
3414:
3411:
3409:
3406:
3405:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3375:
3373:
3369:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3236:
3233:
3231:
3228:
3227:
3226:
3223:
3219:
3216:
3214:
3211:
3210:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3142:
3139:
3137:
3134:
3133:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3098:
3096:
3092:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2981:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2948:
2945:
2943:
2940:
2939:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2862:
2861:
2858:
2854:
2851:
2849:
2846:
2844:
2841:
2840:
2839:
2836:
2834:
2831:
2827:
2824:
2822:
2819:
2817:
2814:
2813:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2758:
2756:
2752:
2746:
2743:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2710:
2709:
2706:
2704:
2701:
2699:
2696:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2653:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2600:
2597:
2595:
2592:
2591:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2513:
2510:
2508:
2505:
2504:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2462:
2461:
2458:
2456:
2453:
2451:
2448:
2444:
2441:
2440:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2412:
2409:
2407:
2404:
2402:
2399:
2398:
2397:
2394:
2392:
2389:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2361:
2360:
2357:
2356:
2354:
2350:
2345:
2341:
2337:
2330:
2325:
2323:
2318:
2316:
2311:
2310:
2307:
2303:
2300:
2299:
2297:
2296:public domain
2293:
2282:
2278:
2274:
2270:
2266:
2262:
2257:
2253:
2249:
2245:
2241:
2237:
2233:
2230:(6): 1400–9.
2229:
2225:
2220:
2216:
2212:
2208:
2204:
2199:
2194:
2191:(7): 973–81.
2190:
2186:
2185:FASEB Journal
2182:
2177:
2173:
2169:
2164:
2159:
2155:
2151:
2147:
2142:
2138:
2134:
2129:
2124:
2120:
2116:
2112:
2107:
2103:
2099:
2094:
2089:
2085:
2081:
2077:
2072:
2068:
2064:
2059:
2054:
2050:
2046:
2045:Endocrinology
2042:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2008:
2004:
2000:
1996:
1992:
1987:
1982:
1978:
1974:
1970:
1965:
1961:
1957:
1952:
1947:
1943:
1939:
1935:
1930:
1926:
1922:
1918:
1914:
1910:
1906:
1902:
1898:
1893:
1889:
1885:
1881:
1877:
1872:
1868:
1864:
1859:
1854:
1849:
1844:
1840:
1836:
1832:
1828:
1824:
1819:
1815:
1811:
1807:
1803:
1797:
1793:
1789:
1784:
1779:
1774:
1769:
1765:
1761:
1757:
1752:
1748:
1744:
1739:
1734:
1730:
1726:
1722:
1718:
1714:
1709:
1705:
1701:
1697:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1627:
1622:
1618:
1614:
1610:
1606:
1603:(1): 309–11.
1602:
1598:
1593:
1592:
1587:
1578:
1574:
1569:
1564:
1559:
1554:
1550:
1546:
1542:
1535:
1532:
1527:
1521:
1519:
1515:
1510:
1506:
1500:
1497:
1492:
1488:
1482:
1479:
1475:
1471:
1466:
1464:
1462:
1458:
1454:
1450:
1444:
1442:
1440:
1436:
1429:
1427:
1425:
1421:
1417:
1412:
1408:
1404:
1403:
1398:
1394:
1387:
1385:
1383:
1379:
1375:
1371:
1367:
1355:
1350:
1346:
1342:
1339:
1335:
1328:
1326:
1323:
1319:
1315:
1311:
1308:
1304:
1300:
1293:
1291:
1287:
1283:
1279:
1273:
1269:
1266:
1260:
1258:
1254:
1250:
1246:
1242:
1238:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1205:
1201:
1194:
1192:
1188:
1184:
1180:
1174:
1170:
1167:
1161:
1159:
1155:
1151:
1147:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1114:
1112:RefSeq (mRNA)
1110:
1103:
1102:
1097:
1093:
1090:
1084:
1083:
1078:
1074:
1071:
1069:
1065:
1058:
1057:
1052:
1048:
1045:
1039:
1038:
1034:
1029:
1024:
1020:
1016:
1012:
1008:
1003:
1000:
998:
994:
987:
986:
981:
977:
974:
968:
967:
962:
958:
955:
953:
949:
946:
943:
941:
938:
934:
931:
927:
923:
916:
912:
907:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
830:cell adhesion
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
762:
760:
757:
756:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
711:
709:
706:
705:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
631:
630:Gene ontology
627:
623:
611:
606:
602:
595:
588:
583:
580:
578:
574:
566:
561:
551:parotid gland
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
5669:expanding it
5658:
5643:
5605:Translocases
5602:
5589:
5576:
5563:
5550:
5540:Transferases
5537:
5524:
5381:Binding site
5227:SRC-B family
5196:SRC-A family
4953:RET receptor
4924:AXL receptor
4846:RYK receptor
4811:
4803:DDR receptor
4802:
4779:ROR receptor
4755:TIE receptor
4731:LTK receptor
4642:EPH receptor
4609:Trk receptor
4585:HGF receptor
4522:FGF receptor
3857:
3777:
3755:
3733:
3580:
3543:
3511:
3506:
3459:
3429:
3402:
3224:
3130:
2978:
2707:
2459:
2301:
2289:
2288:
2267:(1): 87–92.
2264:
2260:
2227:
2224:Neurosurgery
2223:
2188:
2184:
2153:
2149:
2121:(1): 25–34.
2118:
2114:
2086:(1): 13–23.
2083:
2079:
2051:(3): 852–8.
2048:
2044:
2015:
2012:Pathobiology
2011:
1976:
1973:FEBS Letters
1972:
1944:(7): 620–7.
1941:
1937:
1900:
1896:
1879:
1875:
1830:
1826:
1808:(1): 211–9.
1805:
1801:
1783:11380/607761
1763:
1759:
1720:
1716:
1695:
1691:
1661:(1): 18–27.
1658:
1654:
1632:(2): 584–7.
1629:
1625:
1600:
1596:
1548:
1544:
1534:
1508:
1499:
1490:
1481:
1400:
1391:
1373:
1369:
1365:
1364:
1282:NP_001185762
1278:NP_001185760
1275:
1237:NP_001284583
1234:
1227:NP_001284582
1223:NP_001284581
1219:NP_001189452
1215:NP_001189451
1211:NP_001189450
1183:NM_001198833
1179:NM_001198831
1176:
1146:NM_001297654
1143:
1136:NM_001297653
1132:NM_001297652
1128:NM_001202523
1124:NM_001202522
1120:NM_001202521
1099:
1080:
1054:
1031:
983:
964:
944:
939:
547:motor neuron
515:ciliary body
427:
420:
147:External IDs
74:
5376:Active site
1903:(1): 12–5.
1420:HLA class I
1257:NP_054699.2
693:ATP binding
386:36,015,513
373:35,992,459
285:30,900,156
272:30,876,421
125:Identifiers
5708:Categories
5579:Isomerases
5553:Hydrolases
5420:Regulation
2342:(see also
1476:, May 2017
1455:, May 2017
1430:References
1416:esophageal
469:C1 segment
431:(ortholog)
168:HomoloGene
5458:EC number
1414:ovarian,
1407:discoidin
1290:NP_766550
1286:NP_031610
1249:NP_054700
1245:NP_054699
1241:NP_001945
1191:NM_172962
1187:NM_007584
1158:NM_013994
1154:NM_013993
1150:NM_001954
930:Orthologs
845:lactation
176:GeneCards
21:DDR SDRAM
5482:Kinetics
5406:Cofactor
5369:Activity
2336:Proteins
2281:11133186
2244:11126911
2215:43317719
2207:10783152
2172:10681566
1876:Oncogene
1802:Oncogene
1626:Genomics
1597:Genomics
1577:23335507
1472:–
1451:–
1405:protein
1397:collagen
1388:Function
1338:Wikidata
909:Sources:
719:membrane
5638:Biology
5592:Ligases
5362:Enzymes
4383:2.7.10)
4144:301–350
3938:251–300
3890:CD240CE
3687:201–250
3371:151–200
3094:101–150
2252:2299503
2137:9659900
2102:9659899
2067:9492013
2032:9396043
2003:7573214
1995:8977099
1960:8796349
1925:9450185
1917:8682498
1888:8622863
1867:8390675
1835:Bibcode
1814:8302582
1792:8226977
1747:8139570
1704:7848919
1683:2737602
1675:7834423
1646:7789998
1617:7774938
1568:3597784
1474:Ensembl
1453:Ensembl
1422:genes.
1068:UniProt
997:Ensembl
936:Species
915:QuickGO
406:pattern
264:6p21.33
132:Aliases
5624:Portal
5566:Lyases
5300:family
5261:family
5165:family
5136:family
5112:family
5088:family
5064:family
5040:family
5016:family
4955:family
4926:family
4914:AATYK2
4902:family
4867:family
4848:family
4829:family
4805:family
4781:family
4757:family
4733:family
4644:family
4611:family
4587:family
4575:VEGFR3
4570:VEGFR2
4565:VEGFR1
4558:family
4524:family
4511:PDGFRB
4506:PDGFRA
4452:family
4151:CD300A
4110:CDw293
3895:CD240D
3756:CD213a
3734:CDw210
3699:CD202b
3673:CDw199
3668:CDw198
3322:CD140b
2754:51–100
2279:
2250:
2242:
2213:
2205:
2170:
2135:
2100:
2065:
2030:
2001:
1993:
1958:
1923:
1915:
1886:
1865:
1855:
1812:
1790:
1745:
1738:358637
1735:
1702:
1681:
1673:
1644:
1615:
1575:
1565:
1374:CD167a
1324:search
1322:PubMed
1101:Q03146
1082:Q08345
952:Entrez
577:BioGPS
156:600408
5659:This
5518:Types
5312:ZAP70
4978:STYK1
4943:TYRO3
4909:AATYK
4716:EPHB6
4711:EPHB5
4706:EPHB4
4701:EPHB3
4696:EPHB2
4691:EPHB1
4686:EPHA8
4681:EPHA7
4676:EPHA6
4671:EPHA5
4666:EPHA4
4661:EPHA3
4656:EPHA2
4651:EPHA1
4628:NTRK3
4623:NTRK2
4618:NTRK1
4546:FGFR4
4541:FGFR3
4536:FGFR2
4531:FGFR1
4502:PDGFR
4487:CSF1R
4469:INSRR
4459:IGF1R
4440:ERBB4
4435:ERBB3
4430:ERBB2
4331:CD350
4326:CD349
4321:CD344
4316:CD340
4311:CD339
4306:CD338
4301:CD337
4296:CD336
4291:CD335
4286:CD334
4281:CD333
4276:CD332
4271:CD331
4266:CD329
4261:CD328
4256:CD327
4251:CD326
4246:CD325
4241:CD324
4236:CD322
4231:CD321
4226:CD320
4221:CD318
4216:CD317
4211:CD316
4206:CD315
4201:CD314
4196:CD312
4191:CD309
4186:CD307
4181:CD306
4176:CD305
4171:CD304
4166:CD303
4161:CD302
4156:CD301
4135:CD299
4130:CD298
4125:CD297
4120:CD295
4115:CD294
4105:CD292
4100:CD290
4095:CD289
4090:CD288
4085:CD286
4080:CD284
4075:CD283
4070:CD282
4065:CD281
4060:CD280
4055:CD279
4050:CD278
4045:CD276
4040:CD275
4035:CD274
4030:CD273
4025:CD272
4020:CD271
4015:CD269
4010:CD268
4005:CD267
4000:CD266
3995:CD265
3990:CD264
3985:CD263
3980:CD262
3975:CD261
3970:CD258
3965:CD257
3960:CD256
3955:CD254
3950:CD253
3945:CD252
3929:CD249
3924:CD248
3920:CD247
3915:CD246
3910:CD244
3905:CD243
3900:CD241
3885:CD239
3880:CD238
3875:CD236
3858:CD235
3853:CD234
3848:CD233
3843:CD230
3838:CD229
3833:CD228
3828:CD227
3823:CD226
3818:CD225
3813:CD224
3808:CD223
3803:CD222
3798:CD221
3793:CD220
3778:CD218
3773:CD217
3751:CD212
3729:CD209
3724:CD208
3719:CD207
3714:CD206
3709:CD205
3704:CD204
3694:CD201
3678:CD200
3663:CD197
3658:CD196
3653:CD195
3648:CD194
3643:CD193
3638:CD192
3633:CD191
3628:CD186
3623:CD185
3618:CD184
3613:CD183
3608:CD182
3603:CD181
3598:CD180
3581:CD179
3576:CD178
3571:CD177
3566:CD174
3544:CD172
3539:CD171
3534:CD170
3529:CD169
3524:CD168
3507:CD167
3502:CD166
3497:CD164
3492:CD163
3487:CD162
3482:CD161
3477:CD160
3460:CD159
3430:CD158
3425:CD157
3403:CD156
3398:CD155
3393:CD154
3388:CD153
3383:CD152
3378:CD151
3362:CD150
3357:CD148
3352:CD147
3347:CD146
3342:CD144
3337:CD143
3332:CD142
3327:CD141
3317:CD138
3312:CD137
3307:CD136
3302:CD135
3297:CD134
3292:CD133
3287:CD132
3282:CD131
3277:CD130
3272:CD129
3267:CD127
3262:CD126
3257:CD125
3252:CD124
3247:CD123
3242:CD122
3225:CD121
3208:CD120
3203:CD119
3198:CD118
3193:CD117
3188:CD116
3183:CD115
3178:CD114
3173:CD113
3168:CD112
3163:CD111
3158:CD110
3153:CD109
3148:CD108
3131:CD107
3126:CD106
3121:CD105
3116:CD104
3111:CD103
3106:CD102
3101:CD101
3085:CD100
2248:S2CID
2211:S2CID
1999:S2CID
1921:S2CID
1858:46784
1679:S2CID
985:12305
945:Mouse
940:Human
911:Amigo
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
172:68212
164:99216
5665:stub
5610:list
5603:EC7
5597:list
5590:EC6
5584:list
5577:EC5
5571:list
5564:EC4
5558:list
5551:EC3
5545:list
5538:EC2
5532:list
5525:EC1
5218:YES1
5187:TYK2
5182:JAK3
5177:JAK2
5172:JAK1
5153:SRMS
5100:PYK2
5076:MATK
5052:TNK1
5047:ACK1
5023:ABL1
4890:ROS1
4874:MUSK
4836:PTK7
4817:DDR2
4812:DDR1
4793:ROR2
4788:ROR1
4721:EPHX
4492:FLT3
4464:INSR
4425:EGFR
3080:CD99
3075:CD98
3070:CD97
3065:CD96
3060:CD95
3055:CD94
3050:CD93
3045:CD92
3041:CD91
3036:CD90
3031:CD89
3026:CD88
3021:CD87
3016:CD86
2979:CD85
2974:CD84
2969:CD83
2964:CD82
2959:CD81
2954:CD80
2937:CD79
2932:CD78
2927:CD74
2922:CD73
2917:CD72
2912:CD71
2907:CD70
2902:CD69
2897:CD68
2860:CD66
2838:CD64
2833:CD63
2811:CD62
2806:CD61
2801:CD59
2796:CD58
2791:CD57
2786:CD56
2781:CD55
2776:CD54
2771:CD53
2766:CD52
2761:CD51
2745:CD50
2708:CD49
2703:CD48
2698:CD47
2693:CD46
2688:CD45
2683:CD44
2678:CD43
2651:CD42
2646:CD41
2641:CD40
2636:CD39
2631:CD38
2626:CD37
2621:CD36
2616:CD35
2611:CD34
2606:CD33
2589:CD32
2584:CD31
2579:CD30
2574:CD29
2569:CD28
2564:CD27
2559:CD26
2554:CD25
2549:CD24
2544:CD23
2539:CD22
2534:CD21
2529:CD20
2524:CD19
2519:CD18
2502:CD16
2497:CD15
2492:CD14
2487:CD13
2460:CD11
2455:CD10
2352:1–50
2277:PMID
2240:PMID
2203:PMID
2168:PMID
2133:PMID
2098:PMID
2063:PMID
2028:PMID
1991:PMID
1956:PMID
1913:PMID
1884:PMID
1863:PMID
1810:PMID
1788:PMID
1743:PMID
1700:PMID
1671:PMID
1642:PMID
1613:PMID
1573:PMID
1411:DDR2
1382:gene
1370:DDR1
519:iris
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
180:DDR1
152:OMIM
139:DDR1
109:5FDP
105:5BVW
101:5BVO
97:5BVN
93:5BVK
89:4CKR
85:4BKJ
81:4AG4
77:3ZOS
58:RCSB
55:PDBe
29:DDR1
5307:SYK
5298:SYK
5288:TXK
5283:ITK
5278:BTK
5273:BMX
5268:TEC
5259:TEC
5249:LYN
5244:LCK
5239:HCK
5234:BLK
5213:FYN
5208:FGR
5203:SRC
5163:JAK
5148:BRK
5143:FRK
5134:FRK
5124:FER
5119:FES
5110:FES
5095:FAK
5086:FAK
5071:CSK
5062:CSK
5038:ACK
5028:ARG
5014:ABL
4962:RET
4938:MER
4933:AXL
4855:RYK
4769:TEK
4764:TIE
4745:ALK
4740:LTK
4599:RON
4594:MET
4497:KIT
2450:CD9
2438:CD8
2433:CD7
2428:CD6
2423:CD5
2418:CD4
2396:CD3
2391:CD2
2364:a-c
2359:CD1
2269:doi
2232:doi
2193:doi
2158:doi
2154:275
2123:doi
2088:doi
2053:doi
2049:139
2020:doi
1981:doi
1977:398
1946:doi
1905:doi
1853:PMC
1843:doi
1778:hdl
1768:doi
1764:268
1733:PMC
1725:doi
1663:doi
1634:doi
1605:doi
1563:PMC
1553:doi
1549:288
1372:or
966:780
382:End
281:End
184:OMA
160:MGI
48:PDB
5710::
4381:EC
4375::
3922:-
3043:-
2384:1E
2379:1D
2374:1B
2369:1A
2338::
2275:.
2265:72
2263:.
2246:.
2238:.
2228:47
2226:.
2209:.
2201:.
2189:14
2187:.
2183:.
2166:.
2152:.
2148:.
2131:.
2117:.
2113:.
2096:.
2082:.
2078:.
2061:.
2047:.
2043:.
2026:.
2016:65
2014:.
1997:.
1989:.
1975:.
1971:.
1954:.
1940:.
1936:.
1919:.
1911:.
1901:98
1899:.
1880:12
1878:.
1861:.
1851:.
1841:.
1831:90
1829:.
1825:.
1804:.
1786:.
1776:.
1762:.
1758:.
1741:.
1731:.
1721:14
1719:.
1715:.
1694:.
1677:.
1669:.
1657:.
1640:.
1630:25
1628:.
1611:.
1601:25
1599:.
1571:.
1561:.
1547:.
1543:.
1517:^
1507:.
1489:.
1460:^
1438:^
1384:.
913:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
5696:e
5689:t
5682:v
5671:.
5626::
5612:)
5608:(
5599:)
5595:(
5586:)
5582:(
5573:)
5569:(
5560:)
5556:(
5547:)
5543:(
5534:)
5530:(
5354:e
5347:t
5340:v
4513:)
4504:(
4379:(
4365:e
4358:t
4351:v
3868:b
3863:a
3789:)
3787:b
3782:a
3780:(
3766:2
3761:1
3744:b
3739:a
3591:b
3586:a
3559:g
3554:b
3549:a
3517:b
3512:a
3470:c
3465:a
3456:)
3454:k
3449:i
3444:e
3439:d
3434:a
3432:(
3418:c
3413:b
3408:a
3235:b
3230:a
3218:b
3213:a
3141:b
3136:a
3009:k
3004:j
2999:h
2994:e
2989:d
2984:a
2947:b
2942:a
2890:f
2885:e
2880:d
2875:c
2870:b
2865:a
2853:C
2848:B
2843:A
2826:P
2821:L
2816:E
2738:f
2733:e
2728:d
2723:c
2718:b
2713:a
2671:d
2666:c
2661:b
2656:a
2599:B
2594:A
2512:B
2507:A
2480:d
2475:c
2470:b
2465:a
2443:a
2411:ε
2406:δ
2401:γ
2346:)
2328:e
2321:t
2314:v
2298:.
2283:.
2271::
2254:.
2234::
2217:.
2195::
2174:.
2160::
2139:.
2125::
2119:1
2104:.
2090::
2084:1
2069:.
2055::
2034:.
2022::
2005:.
1983::
1962:.
1948::
1942:6
1927:.
1907::
1890:.
1869:.
1845::
1837::
1816:.
1806:9
1794:.
1780::
1770::
1749:.
1727::
1706:.
1696:5
1685:.
1665::
1659:1
1648:.
1636::
1619:.
1607::
1579:.
1555::
1528:.
1511:.
1493:.
1376:(
306:)
203:)
186::
23:.
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