344:
321:
218:
243:
609:
602:
595:
3040:
350:
249:
31:
1492:
assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in
57:
1597:) that is bound and activated by DDX3X. Activation of the IRES leads to translation of the MITF mRNA. Mice injected with melanoma cells with a deleted IRES display more aggressive tumor progression including increased lung
1582:
sensitivity. While high DDX3X expressing cells are drug sensitive, more proliferative and less migratory. These phenotypes can be explained by the translational effects on the melanoma transcription factor
2531:"An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo"
2884:
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, et al. (August 2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry".
1521:
binding to exportin-1, were dispensable. DDX3X binding to, and trafficking by, exportin-1 has since been shown not to require the DDX3X helicase domain and be explicitly NES- and Ran-GTP-dependent.
2685:
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".
1578:
Melanoma survival, migration and proliferation is affected by DDX3X activity. Melanoma cells with low DDX3X expression exhibit a high migratory capacity, low proliferation rate and reduced
1493:
intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog.
1513:. It was initially reported that the DDX3X helicase domain was necessary for this interaction, while the canonical features of the trafficking pathway, namely the presence of a
357:
256:
1529:
DDX3X is involved in many different types of cancer. For example, it is abnormally expressed in breast epithelial cancer cells in which its expression is activated by
1590:
1584:
1571:
of Cyclin E1 and thereby facilitating the translation of the protein. Increased protein levels of Cyclin E1 was demonstrated to mediate the transition of
1152:
2847:
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".
1133:
179:
1657:
3039:
1824:
Park SH, Lee SG, Kim Y, Song K (Oct 1998). "Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3→p11.23".
3019:
2964:"DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control"
1763:
54:
1745:
3068:
1549:. Since the expression of DDX3X is affected by the activity of HIF1A, the co-localization of these proteins has also been demonstrated in
343:
1384:
1391:
320:
1870:
1732:
1711:
1568:
1728:
242:
217:
1542:
1707:
1594:
159:
356:
255:
349:
248:
3012:
1637:. In addition, the mRNA level of DDX3X is lower in matched post-relapse melanoma biopsies for patients receiving
1476:. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
1649:
1197:
167:
1927:"Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity"
1537:. Increased expression of DDX3X by HIF1A in hypoxia is initiated by the direct binding of HIF1A to the HIF1A
150:, DBX, DDX14, DDX3, HLP2, CAP-Rf, MRX102, DEAD-box helicase 3, X-linked, DEAD-box helicase 3 X-linked, MRXSSB
2362:
Pugh TJ, Weeraratne SD, Archer TC, Pomeranz
Krummel DA, Auclair D, Bochicchio J, et al. (August 2012).
1178:
1673:
1477:
1983:"Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells"
2652:"Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line"
1634:
1514:
3005:
2375:
2318:
2261:
2155:
1994:
1790:
1538:
231:
2199:
Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, et al. (July 2014).
1613:
during drug treatment explains the development of drug resistant cells frequently detected with low
146:
2804:"Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication"
1678:
1602:
1469:
1346:
1338:
1334:
1283:
1271:
1267:
1981:
Botlagunta M, Krishnamachary B, Vesuna F, Winnard PT, Bol GM, Patel AH, et al. (March 2011).
2950:
2909:
2872:
2710:
1849:
191:
2921:
Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, et al. (September 2005).
1367:
1342:
1308:
1304:
1279:
1275:
2103:"The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma"
2985:
2942:
2901:
2864:
2835:
2790:
2745:
2702:
2673:
2638:
2595:
2560:
2517:
2482:
2447:
2401:
2344:
2287:
2230:
2181:
2124:
2074:
2022:
1958:
1907:
1841:
1806:
608:
601:
139:
47:
2923:"Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC"
2975:
2934:
2893:
2856:
2825:
2815:
2780:
2770:
2735:
2694:
2663:
2628:
2620:
2585:
2550:
2542:
2507:
2472:
2437:
2391:
2383:
2334:
2326:
2277:
2269:
2220:
2212:
2171:
2163:
2114:
2064:
2056:
2012:
2002:
1948:
1938:
1897:
1833:
1798:
436:
367:
311:
266:
2101:
Phung B, Cieśla M, Sanna A, Guzzi N, Beneventi G, Cao Thi Ngoc P, et al. (June 2019).
594:
187:
2922:
1630:
411:
963:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
878:
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
2426:"Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions"
2379:
2322:
2265:
2159:
1998:
1794:
2555:
2530:
2396:
2363:
2339:
2306:
2282:
2249:
2225:
2200:
2176:
2143:
2069:
2044:
2017:
1982:
1953:
1926:
1645:
30:
2830:
2803:
2785:
2758:
2633:
2608:
2590:
2573:
2248:
Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, et al. (August 2012).
2142:
Müller J, Krijgsman O, Tsoi J, Robert L, Hugo W, Song C, et al. (December 2014).
1601:. Interestingly, the DDX3X in melanoma is affected by vemurafenib via an undiscovered
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
3062:
2624:
2305:
Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, et al. (August 2012).
2201:"A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors"
2144:"Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma"
1534:
1518:
637:
2913:
2714:
1853:
2876:
1781:
Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome".
1502:
1481:
429:
208:
171:
2954:
2574:"Gene structure of the human DDX3 and chromosome mapping of its related sequences"
2216:
2119:
2102:
2007:
1802:
195:
1925:
Heaton SM, Atkinson SC, Sweeney MN, Yang SN, Jans DA, Borg NA (September 2019).
1768:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1750:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1638:
1579:
1489:
1472:, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA
2740:
2723:
2668:
2651:
1902:
1885:
512:
2607:
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003).
2364:"Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations"
1598:
1550:
1546:
328:
225:
175:
2724:"Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function"
2512:
2495:
2461:"Hepatitis C virus core protein interacts with a human DEAD box protein DDX3"
1886:"Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function"
2962:
Chang PC, Chi CW, Chau GY, Li FY, Tsai YH, Wu JC, et al. (March 2006).
2546:
2529:
Yagüe J, Alvarez I, Rognan D, Ramos M, Vázquez J, de Castro JA (June 2000).
1661:
1609:
is downregulated by the presence of vemurafenib. However, reduced levels of
1564:
1553:
1506:
1097:
572:
450:
395:
382:
294:
281:
183:
2989:
2980:
2963:
2946:
2938:
2905:
2868:
2839:
2820:
2794:
2775:
2749:
2706:
2677:
2642:
2609:"Regulation of alternative splicing by SRrp86 and its interacting proteins"
2599:
2564:
2521:
2486:
2477:
2460:
2451:
2405:
2348:
2291:
2234:
2185:
2128:
2078:
2026:
1962:
1911:
2442:
2425:
1845:
1810:
1431:
1426:
2060:
1943:
1485:
1473:
1445:
1415:
1242:
1223:
2387:
2330:
2273:
2167:
2045:"DDX3 regulates cell growth through translational control of cyclin E1"
1871:"Entrez Gene: DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked"
1572:
1209:
1164:
1837:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
2897:
2722:
Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT (October 2004).
1884:
Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT (October 2004).
1653:
1451:
1399:
1119:
2860:
2698:
1683:
1530:
2496:"Hepatitis C virus core protein binds to a DEAD box RNA helicase"
1633:. In melanoma the low expression of the gene is linked to a poor
1082:
1078:
1560:
1510:
1458:
1033:
extrinsic apoptotic signaling pathway via death domain receptors
993:
positive regulation of chemokine (C-C motif) ligand 5 production
163:
3001:
1058:
positive regulation of protein serine/threonine kinase activity
617:
2997:
2307:"Dissecting the genomic complexity underlying medulloblastoma"
2250:"Novel mutations target distinct subgroups of medulloblastoma"
1567:. More specifically, DDX3X was shown to directly bind to the
1563:
DDX3X is reported to control cell cycle progression through
953:
positive regulation of G1/S transition of mitotic cell cycle
898:
negative regulation of intrinsic apoptotic signaling pathway
913:
negative regulation of protein-containing complex assembly
1038:
positive regulation of transcription by RNA polymerase II
3048:: Crystal Structure of human DEAD-box RNA helicase DDX3X
1648:, which affects predominantly females and presents with
419:
2650:
Shu H, Chen S, Bi Q, Mumby M, Brekken DL (March 2004).
1063:
positive regulation of canonical Wnt signaling pathway
2043:
Lai MC, Chang WC, Shieh SY, Tarn WY (November 2010).
584:
2424:
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006).
2759:"Within you, without you: HIV-1 Rev and RNA export"
1360:
1327:
1297:
1260:
1724:
1722:
1720:
1703:
1701:
1699:
938:protein localization to cytoplasmic stress granule
782:eukaryotic translation initiation factor 3 complex
761:protein serine/threonine kinase activator activity
1043:positive regulation of interferon-beta production
983:cellular response to arsenic-containing substance
366:
265:
2572:Kim YS, Lee SG, Park SH, Song K (October 2001).
1023:positive regulation of translational initiation
1008:positive regulation of viral genome replication
1729:GRCm38: Ensembl release 89: ENSMUSG00000000787
3013:
8:
1708:GRCh38: Ensembl release 89: ENSG00000215301
3020:
3006:
2998:
1093:
888:regulation of transcription, DNA-templated
633:
407:
306:
203:
65:
2979:
2829:
2819:
2802:Krishnan V, Zeichner SL (December 2004).
2784:
2774:
2739:
2667:
2632:
2589:
2554:
2511:
2476:
2441:
2395:
2338:
2281:
2224:
2175:
2118:
2068:
2016:
2006:
1952:
1942:
1901:
1501:DDX3X performs its functions in the cell
1865:
1863:
1003:positive regulation of apoptotic process
923:negative regulation of apoptotic process
3035:
1695:
1644:Mutations of the DDX3X gene also cause
716:eukaryotic initiation factor 4E binding
1511:exportin-1/CRM1 nuclear export pathway
973:positive regulation of gene expression
20:
2096:
2094:
2092:
2090:
2088:
2038:
2036:
1976:
1974:
1972:
1593:mRNA contains a complex RNA regulon (
958:intrinsic apoptotic signaling pathway
736:translation initiation factor binding
371:
332:
327:
270:
229:
224:
7:
2535:The Journal of Experimental Medicine
2656:Molecular & Cellular Proteomics
2500:The Journal of Biological Chemistry
948:cellular response to osmotic stress
2459:Owsianka AM, Patel AH (May 1999).
1357:
1324:
1294:
1257:
1233:
1214:
1188:
1169:
1143:
1124:
988:negative regulation of cell growth
968:positive regulation of cell growth
933:positive regulation of translation
873:negative regulation of translation
661:nucleoside-triphosphatase activity
589:
507:
445:
424:
14:
1454:that in humans is encoded by the
998:RNA secondary structure unwinding
883:intracellular signal transduction
802:cytosolic small ribosomal subunit
3038:
2625:10.1128/MCB.23.21.7437-7447.2003
2494:Mamiya N, Worman HJ (May 1999).
1635:distant metastasis free survival
607:
600:
593:
355:
348:
342:
319:
254:
247:
241:
216:
29:
681:ribosomal small subunit binding
2613:Molecular and Cellular Biology
2049:Molecular and Cellular Biology
1826:Cytogenetics and Cell Genetics
1509:, exiting the nucleus via the
618:More reference expression data
573:More reference expression data
1:
2591:10.1016/S1016-8478(23)17085-3
1543:chromatin immunoprecipitation
751:RNA strand annealing activity
340:
239:
16:Protein-coding gene in humans
2217:10.1158/2159-8290.CD-13-0424
2120:10.1016/j.celrep.2019.05.069
2008:10.1371/journal.pone.0017563
1803:10.1126/science.278.5338.675
1480:, nuclear and mitochondrial
943:transcription, DNA-templated
842:ficolin-1-rich granule lumen
797:mitochondrial outer membrane
696:transcription factor binding
461:Epithelium of choroid plexus
3069:Genes on human chromosome X
1641:and in progressing tumors.
1515:nuclear export signal (NES)
3085:
2757:Dayton AI (October 2004).
2741:10.1016/j.cell.2004.09.029
2669:10.1074/mcp.D300003-MCP200
1903:10.1016/j.cell.2004.09.029
812:cytoplasmic stress granule
3033:
1764:"Mouse PubMed Reference:"
1746:"Human PubMed Reference:"
1629:gene are associated with
1547:luciferase reporter assay
1430:
1425:
1421:
1414:
1398:
1379:
1364:
1331:
1320:
1301:
1264:
1253:
1240:
1236:
1221:
1217:
1208:
1195:
1191:
1176:
1172:
1163:
1150:
1146:
1131:
1127:
1118:
1103:
1096:
1092:
1076:
1028:regulation of translation
636:
632:
615:
592:
583:
570:
519:
510:
489:mucosa of paranasal sinus
457:
448:
418:
410:
406:
389:
376:
339:
318:
309:
305:
288:
275:
238:
215:
206:
202:
157:
154:
144:
137:
132:
73:
68:
51:
46:
41:
37:
28:
23:
2513:10.1074/jbc.274.22.15751
1497:Sub-cellular trafficking
1068:translational initiation
1053:neutrophil degranulation
978:mature ribosome assembly
2547:10.1084/jem.191.12.2083
1392:Chr X: 13.15 – 13.16 Mb
1385:Chr X: 41.33 – 41.36 Mb
863:stress granule assembly
837:secretory granule lumen
2981:10.1038/sj.onc.1209239
2939:10.1002/pmic.200401217
2821:10.1186/1742-4690-1-42
2776:10.1186/1742-4690-1-35
2478:10.1006/viro.1999.9659
1674:Eukaryotic translation
1478:translation initiation
1018:innate immune response
908:chromosome segregation
2443:10.1038/sj.cr.7290370
2148:Nature Communications
1621:Clinical significance
928:Wnt signaling pathway
903:immune system process
817:extracellular exosome
691:DNA helicase activity
686:RNA stem-loop binding
555:epithelium of stomach
539:mandibular prominence
477:palpebral conjunctiva
373:X A1.1|X 8.17 cM
2849:Nature Biotechnology
2113:(12): 3573–3586.e7.
2061:10.1128/MCB.00560-10
1944:10.3390/cells8101181
1605:. It is unknown how
1589:. The 5' UTR of the
1048:DNA duplex unwinding
827:extracellular region
726:nucleic acid binding
523:maxillary prominence
334:X chromosome (mouse)
232:X chromosome (human)
69:List of PDB id codes
42:Available structures
2687:Nature Cell Biology
2578:Molecules and Cells
2388:10.1038/nature11329
2380:2012Natur.488..106P
2331:10.1038/nature11284
2323:2012Natur.488..100J
2274:10.1038/nature11213
2266:2012Natur.488...43R
2160:2014NatCo...5.5712M
1999:2011PLoSO...617563B
1795:1997Sci...278..675L
1679:DExD/H box proteins
1650:developmental delay
1541:, as verified with
893:ribosome biogenesis
731:mRNA 5'-UTR binding
497:epithelium of colon
2168:10.1038/ncomms6712
1198:ENSMUSG00000000787
856:Biological process
770:Cellular component
741:hydrolase activity
656:nucleotide binding
644:Molecular function
3056:
3055:
2974:(14): 1991–2003.
2436:(11–12): 923–34.
1838:10.1159/000015022
1625:Mutations of the
1470:DEAD box proteins
1441:
1440:
1437:
1436:
1410:
1409:
1375:
1374:
1354:
1353:
1316:
1315:
1291:
1290:
1249:
1248:
1230:
1229:
1204:
1203:
1185:
1184:
1159:
1158:
1140:
1139:
1088:
1087:
918:response to virus
868:apoptotic process
671:helicase activity
628:
627:
624:
623:
579:
578:
566:
565:
504:
503:
402:
401:
301:
300:
196:DDX3X - orthologs
128:
127:
124:
123:
52:Ortholog search:
3076:
3042:
3022:
3015:
3008:
2999:
2993:
2983:
2958:
2917:
2898:10.1038/nmeth776
2880:
2843:
2833:
2823:
2798:
2788:
2778:
2753:
2743:
2718:
2681:
2671:
2646:
2636:
2603:
2593:
2568:
2558:
2525:
2515:
2490:
2480:
2455:
2445:
2410:
2409:
2399:
2374:(7409): 106–10.
2359:
2353:
2352:
2342:
2302:
2296:
2295:
2285:
2245:
2239:
2238:
2228:
2205:Cancer Discovery
2196:
2190:
2189:
2179:
2139:
2133:
2132:
2122:
2098:
2083:
2082:
2072:
2040:
2031:
2030:
2020:
2010:
1978:
1967:
1966:
1956:
1946:
1922:
1916:
1915:
1905:
1881:
1875:
1874:
1867:
1858:
1857:
1821:
1815:
1814:
1789:(5338): 675–80.
1778:
1772:
1771:
1760:
1754:
1753:
1742:
1736:
1726:
1715:
1705:
1539:response element
1423:
1422:
1394:
1387:
1370:
1358:
1349:
1325:
1321:RefSeq (protein)
1311:
1295:
1286:
1258:
1234:
1215:
1189:
1170:
1144:
1125:
1094:
756:cadherin binding
634:
620:
611:
604:
597:
590:
575:
551:genital tubercle
543:primitive streak
515:
513:Top expressed in
508:
481:lactiferous duct
473:secondary oocyte
453:
451:Top expressed in
446:
425:
408:
398:
385:
374:
359:
352:
346:
335:
323:
307:
297:
284:
273:
258:
251:
245:
234:
220:
204:
198:
149:
142:
119:
66:
60:
39:
38:
33:
21:
3084:
3083:
3079:
3078:
3077:
3075:
3074:
3073:
3059:
3058:
3057:
3052:
3049:
3043:
3029:
3026:
2996:
2961:
2933:(14): 3589–99.
2920:
2883:
2861:10.1038/nbt1046
2846:
2801:
2756:
2721:
2699:10.1038/ncb1086
2684:
2649:
2619:(21): 7437–47.
2606:
2571:
2541:(12): 2083–92.
2528:
2506:(22): 15751–6.
2493:
2458:
2423:
2419:
2417:Further reading
2414:
2413:
2361:
2360:
2356:
2317:(7409): 100–5.
2304:
2303:
2299:
2247:
2246:
2242:
2198:
2197:
2193:
2141:
2140:
2136:
2100:
2099:
2086:
2055:(22): 5444–53.
2042:
2041:
2034:
1980:
1979:
1970:
1924:
1923:
1919:
1883:
1882:
1878:
1869:
1868:
1861:
1823:
1822:
1818:
1780:
1779:
1775:
1762:
1761:
1757:
1744:
1743:
1739:
1727:
1718:
1706:
1697:
1692:
1670:
1662:low muscle tone
1652:or disability,
1631:medulloblastoma
1623:
1556:tumor samples.
1527:
1499:
1467:
1432:View/Edit Mouse
1427:View/Edit Human
1390:
1383:
1380:Location (UCSC)
1366:
1345:
1341:
1337:
1333:
1307:
1303:
1282:
1278:
1274:
1270:
1266:
1179:ENSG00000215301
1072:
851:
765:
711:GTPase activity
706:protein binding
701:ATPase activity
676:poly(A) binding
666:CTPase activity
616:
606:
605:
599:
598:
571:
562:
557:
553:
549:
545:
541:
537:
533:
529:
525:
511:
500:
495:
491:
487:
483:
479:
475:
471:
467:
463:
449:
393:
380:
372:
362:
361:
360:
353:
333:
310:Gene location (
292:
279:
271:
261:
260:
259:
252:
230:
207:Gene location (
158:
145:
138:
75:
53:
17:
12:
11:
5:
3082:
3080:
3072:
3071:
3061:
3060:
3054:
3053:
3051:
3050:
3044:
3037:
3034:
3031:
3030:
3027:
3025:
3024:
3017:
3010:
3002:
2995:
2994:
2959:
2918:
2886:Nature Methods
2881:
2844:
2799:
2754:
2719:
2682:
2647:
2604:
2569:
2526:
2491:
2456:
2420:
2418:
2415:
2412:
2411:
2354:
2297:
2260:(7409): 43–8.
2240:
2191:
2134:
2084:
2032:
1968:
1917:
1876:
1859:
1832:(3–4): 178–9.
1816:
1773:
1755:
1737:
1716:
1694:
1693:
1691:
1688:
1687:
1686:
1681:
1676:
1669:
1666:
1646:DDX3X syndrome
1622:
1619:
1526:
1525:Role in cancer
1523:
1498:
1495:
1466:
1463:
1444:ATP-dependent
1439:
1438:
1435:
1434:
1429:
1419:
1418:
1412:
1411:
1408:
1407:
1405:
1403:
1396:
1395:
1388:
1381:
1377:
1376:
1373:
1372:
1362:
1361:
1355:
1352:
1351:
1329:
1328:
1322:
1318:
1317:
1314:
1313:
1299:
1298:
1292:
1289:
1288:
1262:
1261:
1255:
1251:
1250:
1247:
1246:
1238:
1237:
1231:
1228:
1227:
1219:
1218:
1212:
1206:
1205:
1202:
1201:
1193:
1192:
1186:
1183:
1182:
1174:
1173:
1167:
1161:
1160:
1157:
1156:
1148:
1147:
1141:
1138:
1137:
1129:
1128:
1122:
1116:
1115:
1110:
1105:
1101:
1100:
1090:
1089:
1086:
1085:
1074:
1073:
1071:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
859:
857:
853:
852:
850:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
773:
771:
767:
766:
764:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
647:
645:
641:
640:
630:
629:
626:
625:
622:
621:
613:
612:
587:
581:
580:
577:
576:
568:
567:
564:
563:
561:
560:
556:
552:
548:
547:lacrimal gland
544:
540:
536:
535:tail of embryo
532:
528:
524:
520:
517:
516:
505:
502:
501:
499:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
455:
454:
442:
441:
433:
422:
416:
415:
412:RNA expression
404:
403:
400:
399:
391:
387:
386:
378:
375:
370:
364:
363:
354:
347:
341:
337:
336:
331:
325:
324:
316:
315:
303:
302:
299:
298:
290:
286:
285:
277:
274:
269:
263:
262:
253:
246:
240:
236:
235:
228:
222:
221:
213:
212:
200:
199:
156:
152:
151:
143:
135:
134:
130:
129:
126:
125:
122:
121:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3081:
3070:
3067:
3066:
3064:
3047:
3041:
3036:
3032:
3023:
3018:
3016:
3011:
3009:
3004:
3003:
3000:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2960:
2956:
2952:
2948:
2944:
2940:
2936:
2932:
2928:
2924:
2919:
2915:
2911:
2907:
2903:
2899:
2895:
2891:
2887:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2855:(1): 94–101.
2854:
2850:
2845:
2841:
2837:
2832:
2827:
2822:
2817:
2813:
2809:
2808:Retrovirology
2805:
2800:
2796:
2792:
2787:
2782:
2777:
2772:
2768:
2764:
2763:Retrovirology
2760:
2755:
2751:
2747:
2742:
2737:
2734:(3): 381–92.
2733:
2729:
2725:
2720:
2716:
2712:
2708:
2704:
2700:
2696:
2693:(2): 97–105.
2692:
2688:
2683:
2679:
2675:
2670:
2665:
2662:(3): 279–86.
2661:
2657:
2653:
2648:
2644:
2640:
2635:
2630:
2626:
2622:
2618:
2614:
2610:
2605:
2601:
2597:
2592:
2587:
2584:(2): 209–14.
2583:
2579:
2575:
2570:
2566:
2562:
2557:
2552:
2548:
2544:
2540:
2536:
2532:
2527:
2523:
2519:
2514:
2509:
2505:
2501:
2497:
2492:
2488:
2484:
2479:
2474:
2471:(2): 330–40.
2470:
2466:
2462:
2457:
2453:
2449:
2444:
2439:
2435:
2431:
2430:Cell Research
2427:
2422:
2421:
2416:
2407:
2403:
2398:
2393:
2389:
2385:
2381:
2377:
2373:
2369:
2365:
2358:
2355:
2350:
2346:
2341:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2308:
2301:
2298:
2293:
2289:
2284:
2279:
2275:
2271:
2267:
2263:
2259:
2255:
2251:
2244:
2241:
2236:
2232:
2227:
2222:
2218:
2214:
2211:(7): 816–27.
2210:
2206:
2202:
2195:
2192:
2187:
2183:
2178:
2173:
2169:
2165:
2161:
2157:
2153:
2149:
2145:
2138:
2135:
2130:
2126:
2121:
2116:
2112:
2108:
2104:
2097:
2095:
2093:
2091:
2089:
2085:
2080:
2076:
2071:
2066:
2062:
2058:
2054:
2050:
2046:
2039:
2037:
2033:
2028:
2024:
2019:
2014:
2009:
2004:
2000:
1996:
1993:(3): e17563.
1992:
1988:
1984:
1977:
1975:
1973:
1969:
1964:
1960:
1955:
1950:
1945:
1940:
1936:
1932:
1928:
1921:
1918:
1913:
1909:
1904:
1899:
1896:(3): 381–92.
1895:
1891:
1887:
1880:
1877:
1872:
1866:
1864:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1820:
1817:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1777:
1774:
1769:
1765:
1759:
1756:
1751:
1747:
1741:
1738:
1734:
1730:
1725:
1723:
1721:
1717:
1713:
1709:
1704:
1702:
1700:
1696:
1689:
1685:
1682:
1680:
1677:
1675:
1672:
1671:
1667:
1665:
1663:
1659:
1655:
1651:
1647:
1642:
1640:
1636:
1632:
1628:
1620:
1618:
1616:
1612:
1608:
1604:
1600:
1596:
1592:
1588:
1587:
1581:
1576:
1574:
1570:
1566:
1562:
1557:
1555:
1552:
1548:
1544:
1540:
1536:
1532:
1524:
1522:
1520:
1517:on DDX3X and
1516:
1512:
1508:
1504:
1496:
1494:
1491:
1487:
1483:
1479:
1475:
1471:
1464:
1462:
1460:
1457:
1453:
1449:
1447:
1433:
1428:
1424:
1420:
1417:
1413:
1406:
1404:
1401:
1397:
1393:
1389:
1386:
1382:
1378:
1371:
1369:
1363:
1359:
1356:
1350:
1348:
1344:
1340:
1336:
1330:
1326:
1323:
1319:
1312:
1310:
1306:
1300:
1296:
1293:
1287:
1285:
1281:
1277:
1273:
1269:
1263:
1259:
1256:
1254:RefSeq (mRNA)
1252:
1245:
1244:
1239:
1235:
1232:
1226:
1225:
1220:
1216:
1213:
1211:
1207:
1200:
1199:
1194:
1190:
1187:
1181:
1180:
1175:
1171:
1168:
1166:
1162:
1155:
1154:
1149:
1145:
1142:
1136:
1135:
1130:
1126:
1123:
1121:
1117:
1114:
1111:
1109:
1106:
1102:
1099:
1095:
1091:
1084:
1080:
1075:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1049:
1046:
1044:
1041:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1013:viral process
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
860:
858:
855:
854:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
807:mitochondrion
805:
803:
800:
798:
795:
793:
790:
788:
787:nuclear speck
785:
783:
780:
778:
775:
774:
772:
769:
768:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
639:
638:Gene ontology
635:
631:
619:
614:
610:
603:
596:
591:
588:
586:
582:
574:
569:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
521:
518:
514:
509:
506:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
459:
456:
452:
447:
444:
443:
440:
438:
434:
432:
431:
427:
426:
423:
421:
417:
413:
409:
405:
397:
392:
388:
384:
379:
369:
365:
358:
351:
345:
338:
330:
326:
322:
317:
313:
308:
304:
296:
291:
287:
283:
278:
268:
264:
257:
250:
244:
237:
233:
227:
223:
219:
214:
210:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
153:
148:
141:
136:
131:
120:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
3045:
2971:
2967:
2930:
2926:
2892:(8): 591–8.
2889:
2885:
2852:
2848:
2811:
2807:
2766:
2762:
2731:
2727:
2690:
2686:
2659:
2655:
2616:
2612:
2581:
2577:
2538:
2534:
2503:
2499:
2468:
2464:
2433:
2429:
2371:
2367:
2357:
2314:
2310:
2300:
2257:
2253:
2243:
2208:
2204:
2194:
2151:
2147:
2137:
2110:
2107:Cell Reports
2106:
2052:
2048:
1990:
1986:
1937:(10): 1181.
1934:
1930:
1920:
1893:
1889:
1879:
1829:
1825:
1819:
1786:
1782:
1776:
1767:
1758:
1749:
1740:
1643:
1626:
1624:
1617:expression.
1614:
1610:
1606:
1585:
1577:
1558:
1528:
1500:
1468:
1455:
1446:RNA helicase
1443:
1442:
1365:
1347:NP_001350748
1339:NP_001180346
1335:NP_001180345
1332:
1302:
1284:NM_001363819
1272:NM_001193417
1268:NM_001193416
1265:
1241:
1222:
1196:
1177:
1151:
1132:
1112:
1107:
527:cumulus cell
435:
428:
155:External IDs
74:
18:
3028:PDB gallery
2154:(1): 5712.
1639:vemurafenib
1580:vemurafenib
1490:spliceosome
746:ATP binding
721:RNA binding
651:DNA binding
531:human fetus
493:skin of hip
394:13,160,291
381:13,147,209
293:41,364,472
280:41,333,348
133:Identifiers
2927:Proteomics
1735:, May 2017
1714:, May 2017
1690:References
1599:metastasis
1561:HeLa cells
1551:MDA-MB-231
439:(ortholog)
176:HomoloGene
1603:mechanism
1565:Cyclin E1
1554:xenograft
1507:cytoplasm
1474:helicases
1368:NP_034158
1343:NP_001347
1309:NM_008015
1305:NM_010028
1280:NM_024005
1276:NM_001356
1098:Orthologs
847:nucleolus
777:cytoplasm
184:GeneCards
3063:Category
2990:16301996
2968:Oncogene
2947:16097034
2914:20475874
2906:16094384
2869:15592455
2840:15588285
2795:15516266
2750:15507209
2715:11683986
2707:14743216
2678:14729942
2643:14559993
2600:11710523
2565:10859333
2522:10336476
2487:10329544
2465:Virology
2452:16354571
2406:22820256
2349:22832583
2292:22722829
2235:24771846
2186:25502142
2129:31216476
2079:20837705
2027:21448281
1987:PLOS ONE
1963:31575075
1912:15507209
1854:46774908
1731:–
1710:–
1668:See also
1486:ribosome
1482:splicing
1465:Function
1416:Wikidata
1077:Sources:
792:membrane
2877:7200157
2556:2193201
2397:3413789
2376:Bibcode
2340:3662966
2319:Bibcode
2283:3412905
2262:Bibcode
2226:4154497
2177:4428333
2156:Bibcode
2070:2976371
2018:3063174
1995:Bibcode
1954:6848931
1846:9730595
1811:9381176
1791:Bibcode
1783:Science
1733:Ensembl
1712:Ensembl
1575:entry.
1573:S phase
1535:hypoxia
1533:during
1519:Ran-GTP
1503:nucleus
1210:UniProt
1165:Ensembl
1104:Species
1083:QuickGO
832:cytosol
822:nucleus
414:pattern
140:Aliases
2988:
2955:895879
2953:
2945:
2912:
2904:
2875:
2867:
2838:
2831:543576
2828:
2814:: 42.
2793:
2786:526764
2783:
2769:: 35.
2748:
2713:
2705:
2676:
2641:
2634:207616
2631:
2598:
2563:
2553:
2520:
2485:
2450:
2404:
2394:
2368:Nature
2347:
2337:
2311:Nature
2290:
2280:
2254:Nature
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