297:
274:
171:
196:
548:
303:
202:
1710:
50:
1309:
Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1".
1667:"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1"
310:
209:
921:
902:
132:
1779:
1755:
1347:"Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation"
1291:
1774:
1273:
296:
1121:
1128:
273:
1386:
1260:
1239:
195:
170:
1256:
47:
1235:
112:
309:
208:
1748:
302:
201:
1400:
Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination".
1211:
966:
120:
1528:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
947:
1741:
184:
1625:
1582:
99:
1083:
1036:
1195:
144:
1614:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1104:
1057:
1688:
1653:
1600:
1557:
1514:
1471:
1417:
1368:
1327:
92:
40:
1678:
1643:
1633:
1590:
1547:
1539:
1504:
1496:
1461:
1453:
1409:
1358:
1319:
389:
320:
264:
219:
547:
364:
140:
1629:
1586:
1725:
1509:
1485:"Isolation of human Dna2 endonuclease and characterization of its enzymatic properties"
1484:
1466:
1441:
1648:
1613:
1552:
1527:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
720:
715:
710:
705:
700:
695:
679:
674:
669:
664:
659:
654:
649:
644:
634:
629:
624:
619:
614:
609:
604:
599:
594:
589:
1768:
1721:
1199:
576:
124:
382:
161:
148:
1296:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1278:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1413:
465:
281:
178:
128:
1683:
1666:
866:
525:
403:
348:
335:
247:
234:
136:
1657:
1638:
1604:
1561:
1518:
1475:
1421:
1372:
1363:
1346:
1323:
1692:
1331:
1168:
1163:
1500:
1457:
1207:
1203:
1152:
1011:
992:
1595:
1570:
639:
1543:
978:
933:
660:
site-specific endodeoxyribonuclease activity, specific for altered base
69:
1184:
1136:
888:
1709:
1571:"The DNA sequence and comparative analysis of human chromosome 10"
1387:"Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)"
851:
847:
1717:
1191:
116:
556:
737:
mitotic telomere maintenance via semi-conservative replication
1612:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1569:
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004).
372:
1729:
1526:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
837:
regulation of signal transduction by p53 class mediator
1210:
activity, with which it helps catalyze early steps in
822:
telomere maintenance via semi-conservative replication
537:
1665:
Nagase T, Miyajima N, Tanaka A, et al. (1995).
1345:Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006).
1097:
1076:
1050:
1029:
1252:
1250:
1248:
1231:
1229:
1227:
319:
218:
16:Protein-coding gene in the species Homo sapiens
1440:Masuda-Sasa T, Imamura O, Campbell JL (2006).
1257:GRCm38: Ensembl release 89: ENSMUSG00000036875
1749:
103:, DNA2L, hDNA replication helicase/nuclease 2
8:
1483:Kim JH, Kim HD, Ryu GH, et al. (2006).
827:DNA replication, Okazaki fragment processing
1236:GRCh38: Ensembl release 89: ENSG00000138346
747:nucleic acid phosphodiester bond hydrolysis
1756:
1742:
862:
572:
360:
259:
156:
58:
1682:
1647:
1637:
1594:
1551:
1508:
1465:
1362:
476:fetal liver hematopoietic progenitor cell
762:cellular response to DNA damage stimulus
1223:
787:DNA replication, removal of RNA primer
772:positive regulation of DNA replication
18:
675:single-stranded DNA helicase activity
324:
285:
280:
223:
182:
177:
7:
1706:
1704:
1442:"Biochemical analysis of human Dna2"
767:DNA replication checkpoint signaling
504:migratory enteric neural crest cell
1094:
1073:
1047:
1026:
1002:
983:
957:
938:
912:
893:
752:DNA double-strand break processing
542:
460:
398:
377:
14:
1187:that in humans is encoded by the
1708:
595:4 iron, 4 sulfur cluster binding
546:
308:
301:
295:
272:
207:
200:
194:
169:
1780:Human chromosome 10 gene stubs
1402:Trends in Biochemical Sciences
557:More reference expression data
526:More reference expression data
1:
757:mitochondrial DNA replication
620:5'-flap endonuclease activity
293:
192:
1775:Genes on human chromosome 10
1728:. You can help Knowledge by
1618:Proc. Natl. Acad. Sci. U.S.A
701:gamma DNA polymerase complex
438:Epithelium of choroid plexus
645:5'-3' DNA helicase activity
610:iron-sulfur cluster binding
450:stromal cell of endometrium
1796:
1703:
1414:10.1016/j.tibs.2009.01.010
812:G-quadruplex DNA unwinding
512:medial ganglionic eminence
1292:"Mouse PubMed Reference:"
1274:"Human PubMed Reference:"
1167:
1162:
1158:
1151:
1135:
1116:
1101:
1080:
1069:
1054:
1033:
1022:
1009:
1005:
990:
986:
977:
964:
960:
945:
941:
932:
919:
915:
900:
896:
887:
872:
865:
861:
845:
832:replication fork reversal
575:
571:
554:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1212:homologous recombination
1129:Chr 10: 62.78 – 62.81 Mb
1122:Chr 10: 68.41 – 68.47 Mb
742:mitochondrial DNA repair
1639:10.1073/pnas.242603899
1364:10.1074/jbc.M604925200
1324:10.1006/geno.1996.0581
706:mitochondrial nucleoid
1684:10.1093/dnares/2.1.37
1198:of DNA2KL present in
655:endonuclease activity
625:DNA helicase activity
508:mandibular prominence
287:Chromosome 10 (mouse)
185:Chromosome 10 (human)
802:DNA duplex unwinding
797:telomere maintenance
782:base-excision repair
62:List of PDB id codes
35:Available structures
1630:2002PNAS...9916899M
1596:10.1038/nature02462
1587:2004Natur.429..375D
434:right lobe of liver
430:ganglionic eminence
1716:This article on a
1544:10.1101/gr.2596504
1501:10.1093/nar/gkl102
1458:10.1093/nar/gkl070
1181:DNA2-like helicase
967:ENSMUSG00000036875
817:t-circle formation
730:Biological process
689:Cellular component
665:hydrolase activity
640:catalytic activity
600:nucleotide binding
583:Molecular function
500:tibiofemoral joint
1737:
1736:
1624:(26): 16899–903.
1489:Nucleic Acids Res
1446:Nucleic Acids Res
1202:, possesses both
1178:
1177:
1174:
1173:
1147:
1146:
1112:
1111:
1091:
1090:
1065:
1064:
1044:
1043:
1018:
1017:
999:
998:
973:
972:
954:
953:
928:
927:
909:
908:
857:
856:
650:nuclease activity
615:metal ion binding
605:helicase activity
567:
566:
563:
562:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
1787:
1758:
1751:
1744:
1712:
1705:
1696:
1686:
1661:
1651:
1641:
1608:
1598:
1581:(6990): 375–81.
1565:
1555:
1522:
1512:
1479:
1469:
1426:
1425:
1397:
1391:
1390:
1383:
1377:
1376:
1366:
1357:(50): 38555–64.
1342:
1336:
1335:
1306:
1300:
1299:
1288:
1282:
1281:
1270:
1264:
1254:
1243:
1233:
1160:
1159:
1131:
1124:
1107:
1095:
1086:
1074:
1070:RefSeq (protein)
1060:
1048:
1039:
1027:
1003:
984:
958:
939:
913:
894:
863:
573:
559:
550:
543:
528:
480:primitive streak
468:
466:Top expressed in
461:
426:ventricular zone
414:secondary oocyte
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
149:DNA2 - orthologs
102:
95:
72:
59:
53:
32:
31:
19:
1795:
1794:
1790:
1789:
1788:
1786:
1785:
1784:
1765:
1764:
1763:
1762:
1701:
1699:
1664:
1611:
1568:
1538:(10B): 2121–7.
1525:
1482:
1439:
1435:
1433:Further reading
1430:
1429:
1399:
1398:
1394:
1385:
1384:
1380:
1344:
1343:
1339:
1308:
1307:
1303:
1290:
1289:
1285:
1272:
1271:
1267:
1255:
1246:
1234:
1225:
1220:
1169:View/Edit Mouse
1164:View/Edit Human
1127:
1120:
1117:Location (UCSC)
1103:
1082:
1056:
1035:
948:ENSG00000138346
841:
792:DNA replication
725:
684:
635:protein binding
630:ATPase activity
555:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
446:trabecular bone
444:
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1793:
1791:
1783:
1782:
1777:
1767:
1766:
1761:
1760:
1753:
1746:
1738:
1735:
1734:
1713:
1698:
1697:
1662:
1609:
1566:
1523:
1495:(6): 1854–64.
1480:
1452:(6): 1865–75.
1436:
1434:
1431:
1428:
1427:
1408:(5): 264–272.
1392:
1378:
1337:
1301:
1283:
1265:
1244:
1222:
1221:
1219:
1216:
1176:
1175:
1172:
1171:
1166:
1156:
1155:
1149:
1148:
1145:
1144:
1142:
1140:
1133:
1132:
1125:
1118:
1114:
1113:
1110:
1109:
1099:
1098:
1092:
1089:
1088:
1078:
1077:
1071:
1067:
1066:
1063:
1062:
1052:
1051:
1045:
1042:
1041:
1031:
1030:
1024:
1020:
1019:
1016:
1015:
1007:
1006:
1000:
997:
996:
988:
987:
981:
975:
974:
971:
970:
962:
961:
955:
952:
951:
943:
942:
936:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
879:
874:
870:
869:
859:
858:
855:
854:
843:
842:
840:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
733:
731:
727:
726:
724:
723:
718:
713:
708:
703:
698:
692:
690:
686:
685:
683:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
484:abdominal wall
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1792:
1781:
1778:
1776:
1773:
1772:
1770:
1759:
1754:
1752:
1747:
1745:
1740:
1739:
1733:
1731:
1727:
1723:
1722:chromosome 10
1719:
1714:
1711:
1707:
1702:
1694:
1690:
1685:
1680:
1676:
1672:
1668:
1663:
1659:
1655:
1650:
1645:
1640:
1635:
1631:
1627:
1623:
1619:
1615:
1610:
1606:
1602:
1597:
1592:
1588:
1584:
1580:
1576:
1572:
1567:
1563:
1559:
1554:
1549:
1545:
1541:
1537:
1533:
1529:
1524:
1520:
1516:
1511:
1506:
1502:
1498:
1494:
1490:
1486:
1481:
1477:
1473:
1468:
1463:
1459:
1455:
1451:
1447:
1443:
1438:
1437:
1432:
1423:
1419:
1415:
1411:
1407:
1403:
1396:
1393:
1388:
1382:
1379:
1374:
1370:
1365:
1360:
1356:
1352:
1348:
1341:
1338:
1333:
1329:
1325:
1321:
1318:(3): 408–10.
1317:
1313:
1305:
1302:
1297:
1293:
1287:
1284:
1279:
1275:
1269:
1266:
1262:
1258:
1253:
1251:
1249:
1245:
1241:
1237:
1232:
1230:
1228:
1224:
1217:
1215:
1213:
1209:
1205:
1201:
1200:budding yeast
1197:
1193:
1190:
1186:
1182:
1170:
1165:
1161:
1157:
1154:
1150:
1143:
1141:
1138:
1134:
1130:
1126:
1123:
1119:
1115:
1108:
1106:
1100:
1096:
1093:
1087:
1085:
1079:
1075:
1072:
1068:
1061:
1059:
1053:
1049:
1046:
1040:
1038:
1032:
1028:
1025:
1023:RefSeq (mRNA)
1021:
1014:
1013:
1008:
1004:
1001:
995:
994:
989:
985:
982:
980:
976:
969:
968:
963:
959:
956:
950:
949:
944:
940:
937:
935:
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
883:
880:
878:
875:
871:
868:
864:
860:
853:
849:
844:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
734:
732:
729:
728:
722:
719:
717:
716:mitochondrion
714:
712:
709:
707:
704:
702:
699:
697:
694:
693:
691:
688:
687:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
326:10|10 B4
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1730:expanding it
1715:
1700:
1677:(1): 37–43.
1674:
1670:
1621:
1617:
1578:
1574:
1535:
1531:
1492:
1488:
1449:
1445:
1405:
1401:
1395:
1381:
1354:
1350:
1340:
1315:
1311:
1304:
1295:
1286:
1277:
1268:
1188:
1180:
1179:
1102:
1084:NP_001073918
1081:
1055:
1037:NM_001080449
1034:
1010:
991:
965:
946:
920:
901:
881:
876:
496:otic vesicle
488:otic placode
388:
381:
108:External IDs
67:
1351:J Biol Chem
1194:. Dna2, a
696:nucleoplasm
680:RNA binding
670:ATP binding
590:DNA binding
347:62,809,964
334:62,782,805
246:68,472,121
233:68,414,064
86:Identifiers
1769:Categories
1532:Genome Res
1263:, May 2017
1242:, May 2017
1218:References
807:DNA repair
777:metabolism
392:(ortholog)
129:HomoloGene
1720:on human
1105:NP_796346
1058:NM_177372
867:Orthologs
721:cytoplasm
137:GeneCards
1658:12477932
1605:15164054
1562:15489334
1519:16595799
1476:16595800
1422:19375328
1373:17032657
1312:Genomics
1259:–
1238:–
1208:nuclease
1204:helicase
1153:Wikidata
846:Sources:
492:epiblast
422:testicle
1693:7788527
1671:DNA Res
1626:Bibcode
1583:Bibcode
1510:1428795
1467:1428797
1332:8938459
1261:Ensembl
1240:Ensembl
1196:homolog
979:UniProt
934:Ensembl
873:Species
852:QuickGO
711:nucleus
367:pattern
225:10q21.3
125:2443732
93:Aliases
1691:
1656:
1649:139241
1646:
1603:
1575:Nature
1560:
1553:528928
1550:
1517:
1507:
1474:
1464:
1420:
1371:
1330:
1185:enzyme
1183:is an
1139:search
1137:PubMed
1012:Q6ZQJ5
993:P51530
922:327762
889:Entrez
538:BioGPS
442:rectum
117:601810
1724:is a
882:Mouse
877:Human
848:Amigo
418:gonad
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
1726:stub
1718:gene
1689:PMID
1654:PMID
1601:PMID
1558:PMID
1515:PMID
1472:PMID
1418:PMID
1369:PMID
1328:PMID
1206:and
1192:gene
1189:DNA2
903:1763
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
141:DNA2
133:6124
113:OMIM
100:DNA2
70:5EAY
51:RCSB
48:PDBe
22:DNA2
1679:doi
1644:PMC
1634:doi
1591:doi
1579:429
1548:PMC
1540:doi
1505:PMC
1497:doi
1462:PMC
1454:doi
1410:doi
1359:doi
1355:281
1320:doi
343:End
242:End
145:OMA
121:MGI
41:PDB
1771::
1687:.
1673:.
1669:.
1652:.
1642:.
1632:.
1622:99
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1599:.
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1556:.
1546:.
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1503:.
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1491:.
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1448:.
1444:.
1416:.
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1404:.
1367:.
1353:.
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1326:.
1316:37
1314:.
1294:.
1276:.
1247:^
1226:^
1214:.
850:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
1757:e
1750:t
1743:v
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1675:2
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