336:
313:
210:
235:
2858:
587:
2843:
342:
241:
1438:(NHEJ) and results in accumulation of DNA double-strand breaks and enhanced apoptosis. Lig4 deficiency in the mouse causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during aging. The sensitivity of haematopoietic stem cells to lig4 deficiency suggests that lig4-mediated NHEJ is a key determinant of the ability of stem cells to maintain themselves against physiological stress over time.
31:
1470:
LIG4 is an ATP-dependent DNA ligase. LIG4 uses ATP to adenylate itself and then transfers the AMP group to the 5' phosphate of one DNA end. Nucleophilic attack by the 3' hydroxyl group of a second DNA end and release of AMP yield the ligation product. Adenylation of LIG4 is stimulated by
57:
1845:
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ (June 2007). "DNA repair is limiting for haematopoietic stem cells during ageing".
1633:
Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT (February 2010).
1426:. This syndrome is characterized by cellular radiation sensitivity, growth retardation, developmental delay, microcephaly, facial dysmorphisms, increased disposition to leukemia, variable degrees of immunodeficiency and reduced number of blood cells.
1700:"A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors"
1698:
Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M (August 2013).
2539:
O'Driscoll M, Cerosaletti KM, Girard PM, Dai Y, Stumm M, Kysela B, Hirsch B, Gennery A, Palmer SE, Seidel J, Gatti RA, Varon R, Oettinger MA, Neitzel H, Jeggo PA, Concannon P (December 2001).
1747:
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL (June 2007). "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age".
349:
248:
2276:
Riballo E, Critchlow SE, Teo SH, Doherty AJ, Priestley A, Broughton B, Kysela B, Beamish H, Plowman N, Arlett CF, Lehmann AR, Jackson SP, Jeggo PA (July 1999).
1434:
Accumulation of DNA damage leading to stem cell exhaustion is regarded as an important aspect of aging. Deficiency of lig4 in pluripotent stem cells impairs
2857:
2759:"Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination"
2502:
Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L (December 2001). "Crystal structure of an Xrcc4-DNA ligase IV complex".
1590:
Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L (December 2001). "Crystal structure of an Xrcc4-DNA ligase IV complex".
1005:
2692:
1799:
986:
171:
2036:"Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination"
2434:"DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system"
1983:"XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair"
1555:
1410:, which are also required for NHEJ. The crystal structure of the Lig4/XRCC4 complex has been resolved. Defects in this gene are the cause of
2886:
2822:
1815:
1537:
2842:
1946:
Bryans M, Valenzano MC, Stamato TD (January 1999). "Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4".
1476:
1301:
335:
2574:
Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM, Day NE, Easton DF, Ponder BA, Pharoah PD, Dunning A (June 2002).
1308:
312:
1573:
1524:
1503:
234:
209:
2611:"Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair"
1520:
54:
1807:
1499:
151:
2243:"DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes"
1447:
1636:"Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome"
348:
247:
1435:
1395:
2815:
341:
240:
1050:
159:
2739:
2034:
Wei YF, Robins P, Carter K, Caldecott K, Pappin DJ, Yu GL, Wang RP, Shell BK, Nash RA, Schär P (June 1995).
1821:
1031:
1899:"Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4"
1387:
223:
2808:
2707:
2469:"Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity"
2289:
2211:
2168:
1855:
1756:
1647:
2541:"DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency"
2399:"Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase"
138:
2891:
1399:
1284:
1259:
1255:
1251:
1247:
1243:
1239:
1235:
1225:
1213:
1209:
1189:
1164:
1160:
1156:
1152:
1148:
1144:
1140:
1130:
1126:
1114:
2731:
2527:
2143:
2114:"Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells"
1879:
1780:
1615:
183:
2321:"Substrate specificities and identification of putative substrates of ATM kinase family members"
1280:
1221:
1217:
1185:
1122:
1118:
2788:
2723:
2675:
2640:
2597:
2562:
2519:
2490:
2455:
2420:
2385:
2342:
2307:
2264:
2229:
2200:"DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains"
2186:
2135:
2100:
2065:
2012:
1963:
1928:
1871:
1811:
1772:
1729:
1675:
1607:
131:
47:
2778:
2770:
2715:
2665:
2630:
2622:
2587:
2552:
2511:
2480:
2445:
2410:
2375:
2367:
2332:
2297:
2254:
2219:
2176:
2125:
2090:
2055:
2047:
2002:
1994:
1955:
1918:
1910:
1863:
1764:
1719:
1711:
1665:
1655:
1599:
428:
359:
303:
258:
586:
403:
179:
2711:
2293:
2215:
2172:
1859:
1760:
1651:
2783:
2758:
2467:
Riballo E, Doherty AJ, Dai Y, Stiff T, Oettinger MA, Jeggo PA, Kysela B (August 2001).
2007:
1982:
1923:
1898:
1724:
1699:
1670:
1635:
2719:
2670:
2653:
2635:
2610:
2557:
2540:
2302:
2277:
2259:
2242:
2224:
2199:
2181:
2156:
2060:
2035:
1959:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
719:
714:
709:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
30:
2880:
2688:
2626:
2380:
2355:
2157:"Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV"
1423:
1411:
615:
2735:
2531:
2371:
1619:
163:
2757:
Roddam PL, Rollinson S, O'Driscoll M, Jeggo PA, Jack A, Morgan GJ (December 2002).
2576:"Variants in DNA double-strand break repair genes and breast cancer susceptibility"
2278:"Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient"
2147:
1883:
1784:
421:
200:
1458:. This interaction stabilizes LIG4 protein in cells; cells that are deficient for
1914:
187:
2112:
Grawunder U, Wilm M, Wu X, Kulesza P, Wilson TE, Mann M, Lieber MR (July 1997).
1560:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1542:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1455:
1640:
Proceedings of the
National Academy of Sciences of the United States of America
1422:
In humans, deficiency of DNA ligase 4 results in a clinical condition known as
504:
2693:"DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2"
1391:
320:
217:
167:
2592:
2575:
2337:
2320:
2095:
2078:
1660:
950:
564:
442:
387:
374:
286:
273:
175:
2792:
2727:
2679:
2644:
2601:
2566:
2523:
2494:
2485:
2468:
2459:
2450:
2433:
2424:
2415:
2398:
2389:
2346:
2311:
2016:
1967:
1932:
1875:
1776:
1733:
1679:
1611:
1406:, and further interacts with the DNA-dependent protein kinase (DNA-PK) and
2774:
2268:
2233:
2190:
2139:
2104:
2069:
2051:
1998:
1348:
1343:
1981:
Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP (February 2013).
1332:
1095:
1076:
1867:
1768:
1715:
2241:
Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR (October 1998).
1800:"Chapter 1: Cancer and aging as consequences of un-repaired DNA damage"
1062:
1017:
108:
104:
100:
96:
92:
88:
84:
80:
76:
1368:
1316:
972:
2866:: Solution structure of the first BRCT domain of human DNA ligase IV
2609:
Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (July 2002).
2354:
Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA (May 2000).
2515:
1603:
2130:
2113:
1472:
1459:
1451:
1407:
1403:
741:
double-strand break repair via classical nonhomologous end joining
1398:
pathway of double-strand break repair. It is also essential for
935:
931:
1798:
Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008).
1375:
155:
2804:
595:
2800:
2691:, Holtgreve-Grez H, Jauch A, de Lange T (October 2002).
2397:
Chen L, Trujillo K, Sung P, Tomkinson AE (August 2000).
871:
double-strand break repair via nonhomologous end joining
411:
2319:
Kim ST, Lim DS, Canman CE, Kastan MB (December 1999).
2432:
Lee KJ, Huang J, Takeda Y, Dynan WS (November 2000).
2356:"Ku recruits the XRCC4-ligase IV complex to DNA ends"
576:
2851:: CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
2155:
Critchlow SE, Bowater RP, Jackson SP (August 1997).
1462:, such as XR-1 cells, have reduced levels of LIG4.
1273:
1208:
1178:
1113:
1516:
1514:
1512:
1495:
1493:
1491:
1574:"Entrez Gene: LIG4 ligase IV, DNA, ATP-dependent"
710:DNA-dependent protein kinase-DNA ligase 4 complex
358:
257:
916:negative regulation of neuron apoptotic process
876:positive regulation of fibroblast proliferation
2198:Grawunder U, Zimmer D, Lieber MR (July 1998).
1585:
1583:
1521:GRCm38: Ensembl release 89: ENSMUSG00000049717
791:positive regulation of chromosome organization
2816:
8:
796:establishment of integrated proviral latency
1500:GRCh38: Ensembl release 89: ENSG00000174405
1394:that joins double-strand breaks during the
736:nucleotide-excision repair, DNA gap filling
2823:
2809:
2801:
2654:"Amplifying mechanisms of lymphomagenesis"
1205:
1110:
946:
816:DNA ligation involved in DNA recombination
611:
399:
298:
195:
65:
2782:
2669:
2634:
2591:
2556:
2484:
2449:
2414:
2379:
2336:
2301:
2258:
2223:
2180:
2129:
2094:
2059:
2006:
1922:
1840:
1838:
1723:
1693:
1691:
1689:
1669:
1659:
1897:Deshpande RA, Wilson TE (October 2007).
831:somatic stem cell population maintenance
776:cellular response to DNA damage stimulus
2838:
1487:
921:cellular response to ionizing radiation
2077:Robins P, Lindahl T (September 1996).
1414:. The yeast homolog of Lig4 is Dnl4.
20:
2079:"DNA ligase IV from HeLa cell nuclei"
720:cytoplasmic ribonucleoprotein granule
363:
324:
319:
262:
221:
216:
7:
2473:The Journal of Biological Chemistry
2438:The Journal of Biological Chemistry
2403:The Journal of Biological Chemistry
2325:The Journal of Biological Chemistry
2083:The Journal of Biological Chemistry
841:T cell receptor V(D)J recombination
826:DNA ligation involved in DNA repair
811:positive regulation of neurogenesis
1270:
1175:
1086:
1067:
1041:
1022:
996:
977:
866:immunoglobulin V(D)J recombination
861:central nervous system development
581:
499:
437:
416:
14:
1371:that in humans is encoded by the
695:nonhomologous end joining complex
2856:
2841:
2627:10.1128/MCB.22.14.5194-5202.2002
1802:. In Kimura H, Suzuki A (eds.).
856:T cell differentiation in thymus
766:cellular response to lithium ion
585:
347:
340:
334:
311:
246:
239:
233:
208:
29:
2372:10.1128/MCB.20.9.2996-3003.2000
2615:Molecular and Cellular Biology
2360:Molecular and Cellular Biology
2040:Molecular and Cellular Biology
1704:Cell Death and Differentiation
1430:Haematopoietic stem cell aging
881:in utero embryonic development
746:response to ionizing radiation
596:More reference expression data
565:More reference expression data
1:
2720:10.1016/S0960-9822(02)01179-X
2671:10.1016/S1097-2765(02)00573-7
2558:10.1016/S1097-2765(01)00408-7
2303:10.1016/S0960-9822(99)80311-X
2260:10.1016/S1097-2765(00)80147-1
2225:10.1016/S0960-9822(07)00349-1
2182:10.1016/S0960-9822(06)00258-2
1987:Biochemistry and Cell Biology
1960:10.1016/s0921-8777(98)00063-9
1808:Nova Science Publishers, Inc.
1402:. Lig4 forms a complex with
886:cell population proliferation
332:
231:
2887:Genes on human chromosome 13
1915:10.1016/j.dnarep.2007.04.014
2763:Journal of Medical Genetics
1804:New Research on DNA Damages
906:response to gamma radiation
2908:
1436:Non-homologous end joining
1396:non-homologous end joining
1302:Chr 13: 108.21 – 108.22 Mb
911:double-strand break repair
896:pro-B cell differentiation
771:single strand break repair
639:protein C-terminus binding
469:retinal pigment epithelium
2836:
2504:Nature Structural Biology
1592:Nature Structural Biology
1556:"Mouse PubMed Reference:"
1538:"Human PubMed Reference:"
1347:
1342:
1338:
1331:
1315:
1296:
1277:
1232:
1201:
1182:
1137:
1106:
1093:
1089:
1074:
1070:
1061:
1048:
1044:
1029:
1025:
1016:
1003:
999:
984:
980:
971:
956:
949:
945:
929:
756:lagging strand elongation
654:DNA ligase (ATP) activity
614:
610:
593:
584:
575:
562:
511:
502:
465:mucosa of paranasal sinus
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
73:
68:
51:
46:
41:
37:
28:
23:
2580:Human Molecular Genetics
2338:10.1074/jbc.274.53.37538
2096:10.1074/jbc.271.39.24257
846:neuron apoptotic process
761:DNA biosynthetic process
1661:10.1073/pnas.0914865107
1446:LIG4 has been shown to
1309:Chr 8: 10.02 – 10.03 Mb
836:chromosome organization
2593:10.1093/hmg/11.12.1399
2486:10.1074/jbc.M103866200
2451:10.1074/jbc.M004011200
2416:10.1074/jbc.M000491200
16:Enzyme found in humans
2775:10.1136/jmg.39.12.900
2652:Roth DB (July 2002).
2052:10.1128/mcb.15.6.3206
1999:10.1139/bcb-2012-0058
690:DNA ligase IV complex
485:primary visual cortex
224:Chromosome 13 (human)
142:, LIG4S, DNA ligase 4
700:condensed chromosome
326:Chromosome 8 (mouse)
69:List of PDB id codes
42:Available structures
2712:2002CBio...12.1635S
2294:1999CBio....9..699R
2216:1998CBio....8..873G
2173:1997CBio....7..588C
1868:10.1038/nature05875
1860:2007Natur.447..686N
1769:10.1038/nature05862
1761:2007Natur.447..725R
1716:10.1038/cdd.2013.44
1652:2010PNAS..107.3024R
1400:V(D)J recombination
1386:DNA ligase 4 is an
891:V(D)J recombination
669:DNA ligase activity
535:trigeminal ganglion
477:islet of Langerhans
1051:ENSMUSG00000049717
729:Biological process
678:Cellular component
629:nucleotide binding
622:Molecular function
543:epithelium of lens
489:lower lobe of lung
2874:
2873:
2409:(34): 26196–205.
1948:Mutation Research
1817:978-1-60456-581-2
1358:
1357:
1354:
1353:
1327:
1326:
1292:
1291:
1267:
1266:
1197:
1196:
1172:
1171:
1102:
1101:
1083:
1082:
1057:
1056:
1038:
1037:
1012:
1011:
993:
992:
941:
940:
851:isotype switching
806:response to X-ray
751:DNA recombination
634:metal ion binding
606:
605:
602:
601:
571:
570:
558:
557:
496:
495:
394:
393:
293:
292:
120:
119:
116:
115:
52:Ortholog search:
2899:
2860:
2845:
2825:
2818:
2811:
2802:
2796:
2786:
2753:
2751:
2750:
2744:
2738:. Archived from
2697:
2687:Smogorzewska A,
2683:
2673:
2648:
2638:
2621:(14): 5194–202.
2605:
2595:
2586:(12): 1399–407.
2570:
2560:
2535:
2498:
2488:
2479:(33): 31124–32.
2463:
2453:
2444:(44): 34787–96.
2428:
2418:
2393:
2383:
2366:(9): 2996–3003.
2350:
2340:
2331:(53): 37538–43.
2315:
2305:
2272:
2262:
2237:
2227:
2194:
2184:
2151:
2133:
2108:
2098:
2089:(39): 24257–61.
2073:
2063:
2021:
2020:
2010:
1978:
1972:
1971:
1943:
1937:
1936:
1926:
1894:
1888:
1887:
1854:(7145): 686–90.
1842:
1833:
1832:
1830:
1829:
1820:. Archived from
1795:
1789:
1788:
1744:
1738:
1737:
1727:
1695:
1684:
1683:
1673:
1663:
1630:
1624:
1623:
1587:
1578:
1577:
1570:
1564:
1563:
1552:
1546:
1545:
1534:
1528:
1518:
1507:
1497:
1340:
1339:
1311:
1304:
1287:
1271:
1262:
1206:
1202:RefSeq (protein)
1192:
1176:
1167:
1111:
1087:
1068:
1042:
1023:
997:
978:
947:
612:
598:
589:
582:
567:
551:substantia nigra
519:secondary oocyte
507:
505:Top expressed in
500:
473:Brodmann area 23
461:secondary oocyte
453:endothelial cell
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
188:LIG4 - orthologs
141:
134:
111:
66:
60:
39:
38:
33:
21:
2907:
2906:
2902:
2901:
2900:
2898:
2897:
2896:
2877:
2876:
2875:
2870:
2867:
2861:
2852:
2846:
2832:
2829:
2799:
2756:
2748:
2746:
2742:
2706:(19): 1635–44.
2700:Current Biology
2695:
2686:
2651:
2608:
2573:
2538:
2501:
2466:
2431:
2396:
2353:
2318:
2288:(13): 699–702.
2282:Current Biology
2275:
2240:
2204:Current Biology
2197:
2161:Current Biology
2154:
2124:(6641): 492–5.
2111:
2076:
2033:
2029:
2027:Further reading
2024:
1980:
1979:
1975:
1945:
1944:
1940:
1909:(10): 1507–16.
1896:
1895:
1891:
1844:
1843:
1836:
1827:
1825:
1818:
1810:pp. 1–47.
1797:
1796:
1792:
1755:(7145): 725–9.
1746:
1745:
1741:
1710:(8): 1089–100.
1697:
1696:
1687:
1632:
1631:
1627:
1589:
1588:
1581:
1572:
1571:
1567:
1554:
1553:
1549:
1536:
1535:
1531:
1519:
1510:
1498:
1489:
1485:
1468:
1444:
1432:
1420:
1384:
1349:View/Edit Mouse
1344:View/Edit Human
1307:
1300:
1297:Location (UCSC)
1283:
1279:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1228:
1224:
1220:
1216:
1212:
1188:
1184:
1163:
1159:
1155:
1151:
1147:
1143:
1139:
1133:
1129:
1125:
1121:
1117:
1032:ENSG00000174405
925:
786:DNA replication
724:
673:
659:ligase activity
644:protein binding
594:
563:
554:
549:
545:
541:
537:
533:
529:
525:
521:
517:
503:
492:
487:
483:
479:
475:
471:
467:
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
75:
53:
17:
12:
11:
5:
2905:
2903:
2895:
2894:
2889:
2879:
2878:
2872:
2871:
2869:
2868:
2862:
2855:
2853:
2847:
2840:
2837:
2834:
2833:
2830:
2828:
2827:
2820:
2813:
2805:
2798:
2797:
2754:
2684:
2658:Molecular Cell
2649:
2606:
2571:
2551:(6): 1175–85.
2545:Molecular Cell
2536:
2516:10.1038/nsb725
2510:(12): 1015–9.
2499:
2464:
2429:
2394:
2351:
2316:
2273:
2247:Molecular Cell
2238:
2195:
2152:
2109:
2074:
2046:(6): 3206–16.
2030:
2028:
2025:
2023:
2022:
1973:
1938:
1889:
1834:
1816:
1790:
1739:
1685:
1625:
1604:10.1038/nsb725
1598:(12): 1015–9.
1579:
1565:
1547:
1529:
1508:
1486:
1484:
1481:
1467:
1464:
1443:
1440:
1431:
1428:
1419:
1416:
1383:
1380:
1356:
1355:
1352:
1351:
1346:
1336:
1335:
1329:
1328:
1325:
1324:
1322:
1320:
1313:
1312:
1305:
1298:
1294:
1293:
1290:
1289:
1275:
1274:
1268:
1265:
1264:
1230:
1229:
1203:
1199:
1198:
1195:
1194:
1180:
1179:
1173:
1170:
1169:
1135:
1134:
1108:
1104:
1103:
1100:
1099:
1091:
1090:
1084:
1081:
1080:
1072:
1071:
1065:
1059:
1058:
1055:
1054:
1046:
1045:
1039:
1036:
1035:
1027:
1026:
1020:
1014:
1013:
1010:
1009:
1001:
1000:
994:
991:
990:
982:
981:
975:
969:
968:
963:
958:
954:
953:
943:
942:
939:
938:
927:
926:
924:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
732:
730:
726:
725:
723:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
631:
625:
623:
619:
618:
608:
607:
604:
603:
600:
599:
591:
590:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
515:primary oocyte
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
481:jejunal mucosa
478:
474:
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2904:
2893:
2890:
2888:
2885:
2884:
2882:
2865:
2859:
2854:
2850:
2844:
2839:
2835:
2826:
2821:
2819:
2814:
2812:
2807:
2806:
2803:
2794:
2790:
2785:
2780:
2776:
2772:
2769:(12): 900–5.
2768:
2764:
2760:
2755:
2745:on 2021-05-08
2741:
2737:
2733:
2729:
2725:
2721:
2717:
2713:
2709:
2705:
2701:
2694:
2690:
2685:
2681:
2677:
2672:
2667:
2663:
2659:
2655:
2650:
2646:
2642:
2637:
2632:
2628:
2624:
2620:
2616:
2612:
2607:
2603:
2599:
2594:
2589:
2585:
2581:
2577:
2572:
2568:
2564:
2559:
2554:
2550:
2546:
2542:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2500:
2496:
2492:
2487:
2482:
2478:
2474:
2470:
2465:
2461:
2457:
2452:
2447:
2443:
2439:
2435:
2430:
2426:
2422:
2417:
2412:
2408:
2404:
2400:
2395:
2391:
2387:
2382:
2377:
2373:
2369:
2365:
2361:
2357:
2352:
2348:
2344:
2339:
2334:
2330:
2326:
2322:
2317:
2313:
2309:
2304:
2299:
2295:
2291:
2287:
2283:
2279:
2274:
2270:
2266:
2261:
2256:
2253:(4): 477–84.
2252:
2248:
2244:
2239:
2235:
2231:
2226:
2221:
2217:
2213:
2210:(15): 873–6.
2209:
2205:
2201:
2196:
2192:
2188:
2183:
2178:
2174:
2170:
2167:(8): 588–98.
2166:
2162:
2158:
2153:
2149:
2145:
2141:
2137:
2132:
2131:10.1038/41358
2127:
2123:
2119:
2115:
2110:
2106:
2102:
2097:
2092:
2088:
2084:
2080:
2075:
2071:
2067:
2062:
2057:
2053:
2049:
2045:
2041:
2037:
2032:
2031:
2026:
2018:
2014:
2009:
2004:
2000:
1996:
1992:
1988:
1984:
1977:
1974:
1969:
1965:
1961:
1957:
1953:
1949:
1942:
1939:
1934:
1930:
1925:
1920:
1916:
1912:
1908:
1904:
1900:
1893:
1890:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1853:
1849:
1841:
1839:
1835:
1824:on 2014-10-25
1823:
1819:
1813:
1809:
1805:
1801:
1794:
1791:
1786:
1782:
1778:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
1743:
1740:
1735:
1731:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1694:
1692:
1690:
1686:
1681:
1677:
1672:
1667:
1662:
1657:
1653:
1649:
1646:(7): 3024–9.
1645:
1641:
1637:
1629:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1586:
1584:
1580:
1575:
1569:
1566:
1561:
1557:
1551:
1548:
1543:
1539:
1533:
1530:
1526:
1522:
1517:
1515:
1513:
1509:
1505:
1501:
1496:
1494:
1492:
1488:
1482:
1480:
1478:
1474:
1465:
1463:
1461:
1457:
1453:
1449:
1441:
1439:
1437:
1429:
1427:
1425:
1424:LIG4 syndrome
1418:LIG4 syndrome
1417:
1415:
1413:
1412:LIG4 syndrome
1409:
1408:XLF/Cernunnos
1405:
1401:
1397:
1393:
1389:
1381:
1379:
1377:
1374:
1370:
1366:
1365:DNA ligase IV
1362:
1350:
1345:
1341:
1337:
1334:
1330:
1323:
1321:
1318:
1314:
1310:
1306:
1303:
1299:
1295:
1288:
1286:
1282:
1276:
1272:
1269:
1263:
1261:
1257:
1253:
1249:
1245:
1241:
1237:
1231:
1227:
1223:
1219:
1215:
1211:
1207:
1204:
1200:
1193:
1191:
1187:
1181:
1177:
1174:
1168:
1166:
1162:
1158:
1154:
1150:
1146:
1142:
1136:
1132:
1128:
1124:
1120:
1116:
1112:
1109:
1107:RefSeq (mRNA)
1105:
1098:
1097:
1092:
1088:
1085:
1079:
1078:
1073:
1069:
1066:
1064:
1060:
1053:
1052:
1047:
1043:
1040:
1034:
1033:
1028:
1024:
1021:
1019:
1015:
1008:
1007:
1002:
998:
995:
989:
988:
983:
979:
976:
974:
970:
967:
964:
962:
959:
955:
952:
948:
944:
937:
933:
928:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
781:cell division
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
733:
731:
728:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
626:
624:
621:
620:
617:
616:Gene ontology
613:
609:
597:
592:
588:
583:
580:
578:
574:
566:
561:
550:
546:
542:
539:otolith organ
538:
534:
530:
526:
522:
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
365:8|8 A1.1
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
2863:
2848:
2766:
2762:
2747:. Retrieved
2740:the original
2703:
2699:
2661:
2657:
2618:
2614:
2583:
2579:
2548:
2544:
2507:
2503:
2476:
2472:
2441:
2437:
2406:
2402:
2363:
2359:
2328:
2324:
2285:
2281:
2250:
2246:
2207:
2203:
2164:
2160:
2121:
2117:
2086:
2082:
2043:
2039:
1993:(1): 31–41.
1990:
1986:
1976:
1951:
1947:
1941:
1906:
1902:
1892:
1851:
1847:
1826:. Retrieved
1822:the original
1806:. New York:
1803:
1793:
1752:
1748:
1742:
1707:
1703:
1643:
1639:
1628:
1595:
1591:
1568:
1559:
1550:
1541:
1532:
1469:
1445:
1442:Interactions
1433:
1421:
1385:
1372:
1364:
1361:DNA ligase 4
1360:
1359:
1285:NP_001363971
1278:
1260:NP_001366024
1256:NP_001339533
1252:NP_001339532
1248:NP_001339531
1244:NP_001339530
1240:NP_001339529
1236:NP_001339528
1233:
1226:NP_001339527
1214:NP_001317524
1210:NP_001091738
1190:NM_001377042
1183:
1165:NM_001379095
1161:NM_001352604
1157:NM_001352603
1153:NM_001352602
1149:NM_001352601
1145:NM_001352600
1141:NM_001352599
1138:
1131:NM_001352598
1127:NM_001330595
1115:NM_001098268
1094:
1075:
1049:
1030:
1004:
985:
965:
960:
821:DNA ligation
427:
420:
285:108,218,368
272:108,207,439
147:External IDs
74:
18:
2831:PDB gallery
2689:Karlseder J
1954:(1): 53–8.
1456:BRCT domain
1390:-dependent
685:nucleoplasm
664:DNA binding
649:ATP binding
386:10,027,686
373:10,019,049
125:Identifiers
2892:DNA repair
2881:Categories
2749:2019-08-19
2664:(1): 1–2.
1903:DNA Repair
1828:2015-05-20
1527:, May 2017
1506:, May 2017
1483:References
1392:DNA ligase
901:DNA repair
801:cell cycle
431:(ortholog)
168:HomoloGene
1466:Mechanism
1281:NP_795927
1222:NP_996820
1218:NP_002303
1186:NM_176953
1123:NM_206937
1119:NM_002312
951:Orthologs
715:cytoplasm
176:GeneCards
2793:12471202
2736:17749937
2728:12361565
2680:12150897
2645:12077346
2602:12023982
2567:11779494
2532:21218268
2524:11702069
2495:11349135
2460:10945980
2425:10854421
2390:10757784
2347:10608806
2312:10395545
2017:23442139
1968:10047779
1933:17567543
1876:17554302
1777:17554309
1734:23722522
1680:20133615
1620:21218268
1612:11702069
1523:–
1502:–
1454:via its
1448:interact
1382:Function
1367:, is an
1333:Wikidata
930:Sources:
2784:1757220
2708:Bibcode
2290:Bibcode
2269:9809069
2234:9705934
2212:Bibcode
2191:9259561
2169:Bibcode
2148:4349909
2140:9242410
2105:8798671
2070:7760816
2008:3725335
1924:2064958
1884:4332976
1856:Bibcode
1785:4416445
1757:Bibcode
1725:3705601
1671:2840307
1648:Bibcode
1525:Ensembl
1504:Ensembl
1063:UniProt
1018:Ensembl
957:Species
936:QuickGO
705:nucleus
547:utricle
406:pattern
264:13q33.3
164:1335098
132:Aliases
2791:
2781:
2734:
2726:
2678:
2643:
2636:139779
2633:
2600:
2565:
2530:
2522:
2493:
2458:
2423:
2388:
2378:
2345:
2310:
2267:
2232:
2189:
2146:
2138:
2118:Nature
2103:
2068:
2061:230553
2058:
2015:
2005:
1966:
1931:
1921:
1882:
1874:
1848:Nature
1814:
1783:
1775:
1749:Nature
1732:
1722:
1678:
1668:
1618:
1610:
1369:enzyme
1319:search
1317:PubMed
1096:Q8BTF7
1077:P49917
1006:319583
973:Entrez
577:BioGPS
527:zygote
523:thymus
457:oocyte
156:601837
2743:(PDF)
2732:S2CID
2696:(PDF)
2528:S2CID
2381:85565
2144:S2CID
1880:S2CID
1781:S2CID
1616:S2CID
1473:XRCC4
1460:XRCC4
1452:XRCC4
1450:with
1404:XRCC4
1363:also
966:Mouse
961:Human
932:Amigo
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
2864:2e2w
2849:1ik9
2789:PMID
2724:PMID
2676:PMID
2641:PMID
2598:PMID
2563:PMID
2520:PMID
2491:PMID
2456:PMID
2421:PMID
2386:PMID
2343:PMID
2308:PMID
2265:PMID
2230:PMID
2187:PMID
2136:PMID
2101:PMID
2066:PMID
2013:PMID
1964:PMID
1929:PMID
1872:PMID
1812:ISBN
1773:PMID
1730:PMID
1676:PMID
1608:PMID
1475:and
1376:gene
1373:LIG4
987:3981
531:hand
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
180:LIG4
172:1736
152:OMIM
139:LIG4
109:4HTP
105:4HTO
101:3W5O
97:3W1G
93:3W1B
89:3VNN
85:3II6
81:2E2W
77:1IK9
58:RCSB
55:PDBe
24:LIG4
2779:PMC
2771:doi
2716:doi
2666:doi
2631:PMC
2623:doi
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