5582:
5387:
5357:
1177:
5807:
4697:
5447:
4517:
4502:
5207:
4577:
4547:
4277:
5642:
5417:
5282:
4652:
4622:
4607:
5507:
4562:
5702:
5687:
5672:
5552:
5537:
5522:
5492:
5477:
5462:
5432:
5372:
5327:
5312:
5297:
5267:
5222:
4637:
1154:
5402:
5882:
5822:
5597:
4907:
4967:
5852:
5777:
4922:
4412:
4472:
5237:
5897:
5867:
5657:
5627:
5612:
5837:
4457:
4427:
5117:
4682:
4592:
4487:
4442:
5192:
5072:
5057:
5027:
5012:
4532:
5567:
5342:
4307:
5762:
4367:
4352:
4712:
4727:
4787:
4772:
4742:
4757:
4322:
5252:
4847:
5927:
4292:
4397:
4097:
5732:
5912:
5747:
4877:
5942:
4832:
4817:
4382:
5177:
4802:
4157:
4142:
4127:
5792:
4937:
4112:
5717:
4892:
5162:
5147:
5132:
5102:
5087:
5042:
4997:
4982:
4952:
4667:
4337:
4232:
4217:
4247:
4262:
4187:
1428:
4202:
1183:
4862:
31:
4172:
2204:
2068:
2344:
levels. Numerous investigators have reported an accumulation of DNA damage with age, especially in brain and liver. Cabelof et al. suggested that the inability of the BER pathway to repair damages over time may provide a mechanistic explanation for the frequent observations of DNA accumulation of
5581:
2415:
is thought to contribute to the regulation of gene expression. Yeast three-hybrid assays have shown that this protein binds to the stem loops within the 3'UTR of the POLB mRNA, however the exact mechanism in how this protein regulates gene expression is still to be determined.
5386:
57:
5356:
5806:
4696:
5446:
4516:
4501:
5206:
4576:
4546:
4276:
5641:
5416:
5281:
4651:
4621:
4606:
5506:
4561:
5701:
5686:
5671:
5551:
5536:
5521:
5491:
5476:
5461:
5431:
5371:
5326:
5311:
5296:
5266:
5221:
4636:
5401:
5881:
5821:
5596:
4906:
4966:
2855:
Bergoglio V, Canitrot Y, Hogarth L, Minto L, Howell SB, Cazaux C, Hoffmann JS (September 2001). "Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents".
5851:
5776:
4921:
4411:
4471:
5236:
5896:
5866:
5656:
5626:
5611:
5836:
4456:
4426:
5116:
4681:
4591:
4486:
4441:
5191:
5071:
5056:
5026:
5011:
4531:
2940:
He F, Yang XP, Srivastava DK, Wilson SH (January 2003). "DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in
Chinese hamster ovary cells by DNA alkylating agent-induced stress".
2391:
structures that influence gene expression. These three-stem loop structures are known as M1, M2, and M3, where M2 and M3 have a key role in gene regulation. M3 contributes to gene expression, as it contains the
5566:
5341:
4012:
Tan XH, Zhao M, Pan KF, Dong Y, Dong B, Feng GJ, et al. (March 2005). "Frequent mutation related with overexpression of DNA polymerase beta in primary tumors and precancerous lesions of human stomach".
4306:
5761:
4366:
3717:
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J (October 1996). "Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity".
4351:
3901:
Sawaya MR, Prasad R, Wilson SH, Kraut J, Pelletier H (September 1997). "Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism".
4711:
3123:
Wang L, Bhattacharyya N, Chelsea DM, Escobar PF, Banerjee S (November 2004). "A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype".
4726:
4786:
4771:
4741:
3513:
Abbotts J, SenGupta DN, Zmudzka B, Widen SG, Notario V, Wilson SH (February 1988). "Expression of human DNA polymerase beta in
Escherichia coli and characterization of the recombinant enzyme".
4756:
4321:
2828:
Bergoglio V, Pillaire MJ, Lacroix-Triki M, Raynaud-Messina B, Canitrot Y, Bieth A, et al. (June 2002). "Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis".
5590:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF OF DATP (1 MILLIMOLAR), MNCL2 (5 MILLIMOLAR), AND LITHIUM SULFATE (75 MILLIMOLAR)
5251:
4846:
5926:
5395:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR), MNCL2 (5 MILLIMOLAR), AND AMMONIUM SULFATE (75 MILLIMOLAR)
4291:
4396:
4096:
5731:
5911:
5746:
4876:
5941:
4831:
4816:
4381:
5365:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR), MGCL2 (5 MILLIMOLAR), AND MNCL2 (5 MILLIMOLAR)
5176:
4801:
4156:
4141:
4126:
3983:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
5791:
2383:(CRE) present in the promoter of the POLB gene in response to exposure to alkylating agents. POLB gene expression is also regulated at the post transcriptional level as the 3'
2336:) the ability to repair DNA damage declined significantly with age, and the reduction in repair capability correlated with decreased levels of DNA polymerase beta at both the
2304:
has no significant effect on the fidelity of DNA synthesis by polymerase beta. This finding was considered to provide evidence against the error catastrophe theory of aging.
4936:
4111:
3747:
Pelletier H, Sawaya MR, Wolfle W, Wilson SH, Kraut J (October 1996). "A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta".
5716:
3776:
Pelletier H, Sawaya MR (October 1996). "Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis".
4891:
3651:
Chang M, Burmer GC, Sweasy J, Loeb LA, Edelhoff S, Disteche CM, et al. (May 1994). "Evidence against DNA polymerase beta as a candidate gene for Werner syndrome".
1190:
5161:
5146:
5131:
5101:
5086:
5041:
4996:
4981:
4951:
4666:
4336:
4231:
4216:
4246:
5815:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF PYROPHOSPHATE (1 MILLIMOLAR) AND MGCL2 (5 MILLIMOLAR)
4705:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (0.01 MILLIMOLAR) AND ZNCL2 (0.02 MILLIMOLAR)
2139:
2103:
5455:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (0.1 MILLIMOLAR) AND MNCL2 (0.5 MILLIMOLAR)
4525:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 7.5
4510:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF A SODIUM-FREE ARTIFICIAL MOTHER LIQUOR AT PH 6.5
5215:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (0.1 MILLIMOLAR) AND IN THE ABSENCE OF NACL
4585:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (15 MILLIMOLAR) AND MGCL2 (15 MILLIMOLAR)
4555:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CACL2 (15 MILLIMOLAR) AND MGCL2 (15 MILLIMOLAR)
4285:: FIDELITY PROPERTIES AND STRUCTURE OF M282L MUTATOR MUTANT OF DNA POLYMERASE: SUBTLE STRUCTURAL CHANGES INFLUENCE THE MECHANISM OF NUCLEOTIDE DISCRIMINATION
5650:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND CUCL2 (0.1 MILLIMOLAR)
5425:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF AZT-TP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5290:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (10 MILLIMOLAR) AND MGCL2 (50 MILLIMOLAR)
4660:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (15 MILLIMOLAR) AND NACL (15 MILLIMOLAR)
4630:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CACL2 (15 MILLIMOLAR) AND NACL (15 MILLIMOLAR)
4615:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF BACL2 (15 MILLIMOLAR) AND NACL (15 MILLIMOLAR)
2400:. M2 has been shown to be evolutionary conserved, and, through mutagenesis, it was shown that this stem loop structure acts as a RNA destabilizing element.
5515:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DDATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
4570:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF KCL (75 MILLIMOLAR) AND MGCL2 (75 MILLIMOLAR)
2986:"Activation of the human DNA polymerase beta promoter by a DNA-alkylating agent through induced phosphorylation of cAMP response element-binding protein-1"
5710:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR)
5695:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR)
5680:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND ZNCL2 (1 MILLIMOLAR)
5560:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5545:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5530:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5500:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5485:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5470:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5440:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5380:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND NICL2 (5 MILLIMOLAR)
5335:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DGTP (1 MILLIMOLAR) AND MGCL2 (5 MILLIMOLAR)
5320:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DCTP (1 MILLIMOLAR) AND MGCL2 (5 MILLIMOLAR)
5305:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MGCL2 (5 MILLIMOLAR)
5275:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND CDCL2 (1 MILLIMOLAR)
5230:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND CACL2 (5 MILLIMOLAR)
4645:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF KCL (75 MILLIMOLAR) AND NACL (75 MILLIMOLAR)
4261:
5410:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF ATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5890:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DTTP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
5830:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND MNCL2 (5 MILLIMOLAR)
1801:
1782:
1115:
4186:
4975:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CDCL2 (0.1 MILLIMOLAR) (FOUR-DAY SOAK)
3622:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
5605:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SOAKED IN THE PRESENCE OF DATP(ALPHA)S AND MNCL2
4915:: Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate
4076:
2508:
4420:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF KCL (150 MILLIMOLAR) AT PH 7.5
4201:
2490:
5975:
3027:"Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1"
4480:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CRCL3 (SATURATED SOLUTION)
3807:"Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein"
3217:"Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein"
1176:
5245:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF ARTIFICIAL MOTHER LIQUOR
2445:
4930:: Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-methylene triphosphate
4861:
4465:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CACL2 (150 MILLIMOLAR)
4435:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF BACL2 (150 MILLIMOLAR)
2753:
2006:
5125:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF ZNCL2 (0.01 MILLIMOLAR)
4690:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF TLCL (0.5 MILLIMOLAR)
4600:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (15 MILLIMOLAR)
4495:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CSCL (150 MILLIMOLAR)
4450:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CACL2 (15 MILLIMOLAR)
1153:
5860:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2',3'-DIDEOXYCYTIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DDCTP AND MNCL2
5785:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2',3'-DIDEOXYCYTIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DDCTP AND MGCL2
5200:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CDCL2 (0.1 MILLIMOLAR)
5080:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (1.0 MILLIMOLAR)
5065:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (0.1 MILLIMOLAR)
5035:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CUCL2 (0.1 MILLIMOLAR)
5020:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF CRCL3 (0.1 MILLIMOLAR)
4540:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF KCL (150 MILLIMOLAR)
2115:
3688:
Chyan YJ, Strauss PR, Wood TG, Wilson SH (August 1996). "Identification of novel mRNA isoforms for human DNA polymerase beta".
2477:
3542:
Dobashi Y, Kubota Y, Shuin T, Torigoe S, Yao M, Hosaka M (April 1995). "Polymorphisms in the human DNA polymerase beta gene".
2771:"Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs"
5905:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND ZNCL2
5875:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DGTP AND MNCL2
5665:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND ZNCL2
5635:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND CRCL3
5620:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND COCL2
3076:"XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair"
5845:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DCTP AND MNCL2
2598:
Subba Rao K, Martin GM, Loeb LA (October 1985). "Fidelity of DNA polymerase-beta in neurons from young and very aged mice".
2473:
54:
5985:
2144:
4171:
1095:
4315:: Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine Template Paired with dCTP
2697:"Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice"
4375:: HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
2425:
5575:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + THYMIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DTTP AND MNCL2
5350:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + THYMIDINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DTTP AND MGCL2
4360:: HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
3264:
Bhattacharyya N, Banerjee S (July 2001). "A novel role of XRCC1 in the functions of a DNA polymerase beta variant".
1189:
3346:
Wang L, Patel U, Ghosh L, Banerjee S (September 1992). "DNA polymerase beta mutations in human colorectal cancer".
5770:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DOUBLE STRANDED DNA (NO 5'-PHOSPHATE)
4069:
1182:
2361:
has been correlated with a number of cancer types, whereas deficiencies in POLB results in hypersensitivity to
1846:
1103:
4720:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF ARTIFICIAL MOTHER LIQUOR
3074:
Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, et al. (January 2001).
2270:
1827:
4735:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF CACL2 (150 MILLIMOLAR)
4795:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF MNCL2 (50 MILLIMOLAR)
4780:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF MGCL2 (50 MILLIMOLAR)
4750:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF CSCL (150 MILLIMOLAR)
2404:
4765:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF KCL (150 MILLIMOLAR)
4330:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF MNCL2 (5 MILLIMOLAR)
4855:: DNA Polymerase beta with a terminated gapped DNA substrate and ddCTP with sodium in the catalytic site
3850:"Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway"
2380:
2259:
5935:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA (NON GAPPED DNA ONLY)
4300:: Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP
3437:"Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells"
5970:
4405:: Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus with dGTP
4105:: NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA, MINIMIZED AVERAGE STRUCTURE
4062:
3943:
3861:
2782:
2650:
2376:
2354:
2317:
2278:
2274:
2247:
2186:
5260:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA (NO 5'-PHOSPHATE)
2120:
1082:
5980:
5740:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ARTIFICIAL MOTHER LIQUOR
3581:"The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression"
2397:
2384:
5920:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SIX BASE PAIRS OF DNA; NATIVE STRUCTURE
5755:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF PYROPHOSPHATE AND MNCL2
4885:: DNA Polymerase beta with a gapped DNA substrate and dUMPNPP with magnesium in the catalytic site
2548:"DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria"
2369:, and chromosomal breaking. Therefore, it is essential that POLB expression is tightly regulated.
3676:
3567:
3148:
3105:
3025:
Sarnowska E, Grzybowska EA, Sobczak K, Konopinski R, Wilczynska A, Szwarc M, et al. (2007).
2966:
2881:
2674:
2623:
2320:
pathway in tissues of young (4-month-old) and old (24-month-old) mice. In all tissues examined (
2190:
1127:
5950:: DNA POLYMERASE BETA (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA (NON GAPPED DNA ONLY)
1984:
1963:
1937:
1916:
4840:: STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
4825:: STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
4030:
4000:
3971:
3918:
3889:
3836:
3793:
3764:
3735:
3705:
3668:
3639:
3610:
3559:
3530:
3501:
3466:
3423:
3390:
3355:
3334:
3281:
3246:
3197:
3140:
3097:
3056:
3007:
2958:
2922:
2873:
2837:
2810:
2749:
2726:
2666:
2615:
2577:
2546:
Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, et al. (December 2017).
2362:
2266:
2198:
1075:
47:
4022:
3992:
3961:
3951:
3910:
3879:
3869:
3826:
3818:
3785:
3756:
3727:
3697:
3660:
3631:
3600:
3592:
3551:
3522:
3491:
3456:
3448:
3415:
3380:
3324:
3316:
3273:
3236:
3228:
3187:
3179:
3132:
3087:
3046:
3038:
2997:
2950:
2912:
2865:
2800:
2790:
2769:
Canitrot Y, Cazaux C, Fréchet M, Bouayadi K, Lesca C, Salles B, Hoffmann JS (October 1998).
2716:
2708:
2658:
2607:
2567:
2559:
2181:
2169:
1269:
1200:
1144:
4390:: Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus
5185:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ZNCL2 AND MGCL2
4810:: CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
4165:: CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA; EVIDENCE FOR A COMMON POLYMERASE MECHANISM
4150:: CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
4135:: CRYSTAL STRUCTURE OF RAT DNA POLYMERASE BETA: EVIDENCE FOR A COMMON POLYMERASE MECHANISM
2393:
2293:
2255:
1427:
1244:
1123:
5800:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF DTTP AND MGCL2
3579:
Chyan YJ, Ackerman S, Shepherd NS, McBride OW, Widen SG, Wilson SH, Wood TG (July 1994).
3367:
Tokui T, Inagaki M, Nishizawa K, Yatani R, Kusagawa M, Ajiro K, et al. (June 1991).
3947:
3865:
3305:"Two regions in human DNA polymerase beta mRNA suppress translation in Escherichia coli"
2786:
2654:
4945:: Human DNA Polymerase beta complexed with tetrahydrofuran (abasic site) containing DNA
4120:: NMR SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA, 55 STRUCTURES
3822:
3369:"Inactivation of DNA polymerase beta by in vitro phosphorylation with protein kinase C"
3232:
3051:
3026:
2721:
2696:
2611:
2572:
2547:
3996:
3831:
3806:
3605:
3580:
3496:
3479:
3461:
3436:
3385:
3368:
3329:
3304:
3241:
3216:
3192:
3167:
3092:
3075:
2712:
1716:
1711:
1706:
1701:
1696:
1691:
1686:
1681:
1676:
1671:
1666:
1661:
1656:
1651:
1646:
1641:
1636:
1631:
1626:
1621:
1616:
1611:
1606:
1601:
1596:
1591:
1586:
1570:
1565:
1560:
1555:
1550:
1545:
1529:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1479:
1474:
1469:
30:
5964:
3966:
3931:
3884:
3849:
3635:
3480:"Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter"
3419:
3402:
SenGupta DN, Zmudzka BZ, Kumar P, Cobianchi F, Skowronski J, Wilson SH (April 1986).
2805:
2770:
2341:
2282:
1456:
3680:
3571:
3152:
2970:
2901:"DNA polymerase beta expression differences in selected human tumors and cell lines"
2885:
2627:
3109:
2678:
2408:
1262:
5725:: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA
3136:
2396:
signal followed by the cleavage and polyadenylation site, thereby contributing to
1107:
4900:: DNA Polymerase Beta with a Benzophenanthrene diol epoxide adducted guanine base
4026:
2563:
1131:
5170:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ZNCL2
5155:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ZNCL2
5140:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ZNCL2
5110:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF ZNCL2
5095:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF NICL2
5050:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF MGCL2
5005:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF COCL2
4990:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF CDCL2
4960:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF CACL2
4675:: DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF NICL2
4345:: 2.3 ANGSTROMS CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF DNA POLYMERASE BETA
2513:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2495:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2072:
Predicted secondary structure of the stem loopII (M2) regulatory element in POLB
3936:
Proceedings of the
National Academy of Sciences of the United States of America
3854:
Proceedings of the
National Academy of Sciences of the United States of America
3805:
Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, Lindahl T (December 1996).
3215:
Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, Lindahl T (December 1996).
2917:
2900:
2775:
Proceedings of the
National Academy of Sciences of the United States of America
2695:
Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo Z, Heydari AR (March 2002).
1345:
2313:
2285:. POLB thus has a key role in maintaining the stability of the mitochondrial
2224:
1161:
1111:
3956:
3596:
3452:
3320:
3002:
2985:
2795:
4240:: REFINED SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA
4225:: REFINED SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF DNA POLYMERASE BETA
3874:
3701:
2388:
2366:
2243:
1746:
1405:
1283:
1228:
1215:
1119:
4255:: CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP
4034:
3285:
3201:
3144:
3101:
3060:
2962:
2926:
2877:
2869:
2841:
2730:
2581:
4004:
3975:
3922:
3893:
3840:
3797:
3768:
3739:
3709:
3672:
3643:
3614:
3563:
3534:
3505:
3470:
3427:
3404:"Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning"
3394:
3359:
3338:
3250:
3011:
2814:
2670:
2619:
2046:
2041:
3183:
3042:
2529:
2333:
2174:
2108:
2030:
1891:
1872:
3526:
3303:
Date T, Tanihara K, Yamamoto S, Nomura N, Matsukage A (September 1992).
2954:
3664:
3555:
2337:
2162:
1858:
1813:
3914:
3789:
3760:
3731:
3277:
1524:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
992:
988:
984:
980:
976:
972:
968:
964:
960:
956:
952:
948:
944:
940:
936:
932:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
868:
864:
860:
856:
852:
848:
844:
840:
836:
832:
828:
824:
820:
816:
812:
808:
804:
800:
796:
792:
788:
784:
780:
776:
772:
768:
764:
760:
756:
752:
748:
744:
740:
736:
732:
728:
724:
720:
716:
712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
648:
644:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
3932:"A variant of DNA polymerase beta acts as a dominant negative mutant"
2662:
2329:
2301:
2297:
2286:
2220:
2014:
1768:
3403:
2132:
4270:: CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP
2353:
DNA polymerase beta maintains genome integrity by participating in
2067:
2450:
2433:
2373:
2325:
2321:
4049:
2096:
1731:
1727:
2429:
2412:
2358:
2231:
2127:
2091:
1099:
4195:: HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA AND DDCTP
4058:
1667:
intrinsic apoptotic signaling pathway in response to DNA damage
1436:
4054:
4050:
Rfam entry for the stem loopII (M2) regulatory element in POLB
2251:
2156:
2641:
Orgel LE (June 1973). "Ageing of clones of mammalian cells".
3435:
Zmudzka BZ, Fornace A, Collins J, Wilson SH (October 1988).
3166:
Fan J, Otterlei M, Wong HK, Tomkinson AE, Wilson DM (2004).
2899:
Srivastava DK, Husain I, Arteaga CL, Wilson SH (June 1999).
1520:
DNA-(apurinic or apyrimidinic site) endonuclease activity
1717:
double-strand break repair via nonhomologous end joining
1252:
3168:"XRCC1 co-localizes and physically interacts with PCNA"
4210:: HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA
3848:
Bennett RA, Wilson DM, Wong D, Demple B (July 1997).
1417:
2277:. Mammalian cell mitochondria contain an efficient
3408:
2269:of mammalian cells is constantly under attack from
2197:
2180:
2168:
2155:
2150:
2138:
2126:
2114:
2102:
2090:
2082:
2077:
2060:
1977:
1956:
1930:
1909:
2469:
2467:
2465:
2387:of the POLB mRNA has been shown to contain three
2281:system employing POLB that removes some frequent
1199:
18:Protein-coding gene in the species Homo sapiens
4870:: Sodium in active site of DNA Polymerase Beta
3930:Bhattacharyya N, Banerjee S (September 1997).
3478:Widen SG, Kedar P, Wilson SH (November 1988).
2690:
2688:
2541:
2539:
2474:GRCm38: Ensembl release 89: ENSMUSG00000031536
1647:immunoglobulin heavy chain V-D-J recombination
4070:
2748:. San Diego: Academic Press. pp. 46–60.
2593:
2591:
2300:from young and very aged mice indicated that
1592:somatic hypermutation of immunoglobulin genes
8:
2524:
2522:
2246:cells, DNA polymerase beta (POLB) performs
1602:nucleotide-excision repair, DNA gap filling
4077:
4063:
4055:
2984:Narayan S, He F, Wilson SH (August 1996).
1742:
1657:somatic diversification of immunoglobulins
1452:
1372:transitional epithelium of urinary bladder
1240:
1139:
65:
3965:
3955:
3883:
3873:
3830:
3604:
3495:
3460:
3384:
3328:
3240:
3191:
3091:
3050:
3001:
2916:
2804:
2794:
2720:
2571:
1642:cellular response to DNA damage stimulus
4092:
2461:
2312:Cabelof et al. measured the ability to
2424:DNA polymerase beta has been shown to
2061:Stem loopII regulatory element in POLB
2057:
20:
1204:
1165:
1160:
7:
1515:DNA-directed DNA polymerase activity
3484:The Journal of Biological Chemistry
3373:The Journal of Biological Chemistry
2990:The Journal of Biological Chemistry
3823:10.1002/j.1460-2075.1996.tb01056.x
3233:10.1002/j.1460-2075.1996.tb01056.x
2612:10.1111/j.1471-4159.1985.tb05553.x
2227:. In humans, it is encoded by the
1974:
1953:
1927:
1906:
1882:
1863:
1837:
1818:
1792:
1773:
1707:base-excision repair, DNA ligation
1422:
1340:
1278:
1257:
14:
4180:: DNA POLYMERASE BETA/DNA COMPLEX
2744:Bernstein C, Bernstein H (1991).
1662:base-excision repair, gap-filling
5940:
5925:
5910:
5895:
5880:
5865:
5850:
5835:
5820:
5805:
5790:
5775:
5760:
5745:
5730:
5715:
5700:
5685:
5670:
5655:
5640:
5625:
5610:
5595:
5580:
5565:
5550:
5535:
5520:
5505:
5490:
5475:
5460:
5445:
5430:
5415:
5400:
5385:
5370:
5355:
5340:
5325:
5310:
5295:
5280:
5265:
5250:
5235:
5220:
5205:
5190:
5175:
5160:
5145:
5130:
5115:
5100:
5085:
5070:
5055:
5040:
5025:
5010:
4995:
4980:
4965:
4950:
4935:
4920:
4905:
4890:
4875:
4860:
4845:
4830:
4815:
4800:
4785:
4770:
4755:
4740:
4725:
4710:
4695:
4680:
4665:
4650:
4635:
4620:
4605:
4590:
4575:
4560:
4545:
4530:
4515:
4500:
4485:
4470:
4455:
4440:
4425:
4410:
4395:
4380:
4365:
4350:
4335:
4320:
4305:
4290:
4275:
4260:
4245:
4230:
4215:
4200:
4185:
4170:
4155:
4140:
4125:
4110:
4095:
2530:"NCBI Gene: DNA polymerase beta"
2066:
1426:
1188:
1181:
1175:
1152:
29:
2292:An analysis of the fidelity of
1480:nucleotidyltransferase activity
1617:homeostasis of number of cells
1437:More reference expression data
1406:More reference expression data
1:
3997:10.1016/S0378-1119(97)00411-3
3497:10.1016/S0021-9258(18)37488-X
3386:10.1016/S0021-9258(18)99092-7
3137:10.1158/0008-5472.CAN-04-2801
3093:10.1016/S0092-8674(01)00195-7
2713:10.1016/s0027-5107(02)00003-9
1607:DNA-dependent DNA replication
1384:vestibular sensory epithelium
1173:
4027:10.1016/j.canlet.2004.07.049
3636:10.1016/0378-1119(94)90802-8
3420:10.1016/0006-291X(86)90916-2
2564:10.1016/j.dnarep.2017.10.011
2372:POLB gene is upregulated by
1637:salivary gland morphogenesis
5976:Genes on human chromosome 8
2407:present within the 3'UTR a
1687:response to gamma radiation
6002:
2746:Aging, Sex, and DNA Repair
2296:by polymerase beta in the
1571:protein-containing complex
4090:
2600:Journal of Neurochemistry
2509:"Mouse PubMed Reference:"
2491:"Human PubMed Reference:"
2357:. Overexpression of POLB
2065:
2045:
2040:
2036:
2029:
2013:
1996:
1981:
1960:
1949:
1934:
1913:
1902:
1889:
1885:
1870:
1866:
1857:
1844:
1840:
1825:
1821:
1812:
1799:
1795:
1780:
1776:
1767:
1752:
1745:
1741:
1725:
1455:
1451:
1434:
1425:
1416:
1403:
1352:
1343:
1290:
1281:
1251:
1243:
1239:
1222:
1209:
1172:
1151:
1142:
1138:
1093:
1090:
1080:
1073:
1068:
73:
68:
51:
46:
41:
37:
28:
23:
3957:10.1073/pnas.94.19.10324
3003:10.1074/jbc.271.31.18508
2918:10.1093/carcin/20.6.1049
2796:10.1073/pnas.95.21.12586
2349:Regulation of expression
1712:protein deubiquitination
1612:DNA biosynthetic process
1587:neuron apoptotic process
1380:Rostral migratory stream
3875:10.1073/pnas.94.14.7166
3702:10.1089/dna.1996.15.653
2405:cis-regulatory elements
2262:, and drug resistance.
2007:Chr 8: 23.12 – 23.14 Mb
1597:pyrimidine dimer repair
1530:DNA polymerase activity
3597:10.1093/nar/22.14.2719
3585:Nucleic Acids Research
3453:10.1093/nar/16.20.9587
3441:Nucleic Acids Research
3321:10.1093/nar/20.18.4859
3309:Nucleic Acids Research
3172:Nucleic Acids Research
3031:Nucleic Acids Research
2870:10.1038/sj.onc.1204743
1682:lymph node development
2403:In addition to these
2381:cAMP response element
2283:oxidative DNA damages
1677:inflammatory response
1622:response to hyperoxia
1298:cerebellar hemisphere
1086:, DNA polymerase beta
5986:DNA-binding proteins
3690:DNA and Cell Biology
2943:Biological Chemistry
2377:transcription factor
2355:base excision repair
2308:Base excision repair
2279:base excision repair
2248:base excision repair
1702:base-excision repair
1470:transferase activity
1388:facial motor nucleus
1206:8 A2|8 11.42 cM
1167:Chromosome 8 (mouse)
69:List of PDB id codes
42:Available structures
3948:1997PNAS...9410324B
3866:1997PNAS...94.7166B
3527:10.1021/bi00403a010
2955:10.1515/BC.2003.003
2787:1998PNAS...9512586C
2655:1973Natur.243..441O
2398:pre-mRNA processing
2250:(BER) required for
2213:DNA polymerase beta
1672:response to ethanol
1556:spindle microtubule
1495:damaged DNA binding
1485:microtubule binding
1364:seminiferous tubule
1314:ganglionic eminence
3665:10.1007/bf00202813
3556:10.1007/bf00208961
3184:10.1093/nar/gkh556
3043:10.1093/nar/gkm502
2379:'s binding to the
1847:ENSMUSG00000031536
1632:spleen development
1580:Biological process
1539:Cellular component
1463:Molecular function
1368:intercostal muscle
1318:thoracic diaphragm
5958:
5957:
3915:10.1021/bi9703812
3790:10.1021/bi960790i
3761:10.1021/bi9529566
3732:10.1021/bi952955d
3278:10.1021/bi0028789
2701:Mutation Research
2363:alkylating agents
2345:damage with age.
2314:repair DNA damage
2267:mitochondrial DNA
2210:
2209:
2056:
2055:
2052:
2051:
2025:
2024:
1992:
1991:
1971:
1970:
1945:
1944:
1924:
1923:
1898:
1897:
1879:
1878:
1853:
1852:
1834:
1833:
1808:
1807:
1789:
1788:
1737:
1736:
1697:apoptotic process
1490:metal ion binding
1447:
1446:
1443:
1442:
1412:
1411:
1399:
1398:
1337:
1336:
1310:cerebellar vermis
1235:
1234:
1064:
1063:
1060:
1059:
52:Ortholog search:
5993:
5944:
5929:
5914:
5899:
5884:
5869:
5854:
5839:
5824:
5809:
5794:
5779:
5764:
5749:
5734:
5719:
5704:
5689:
5674:
5659:
5644:
5629:
5614:
5599:
5584:
5569:
5554:
5539:
5524:
5509:
5494:
5479:
5464:
5449:
5434:
5419:
5404:
5389:
5374:
5359:
5344:
5329:
5314:
5299:
5284:
5269:
5254:
5239:
5224:
5209:
5194:
5179:
5164:
5149:
5134:
5119:
5104:
5089:
5074:
5059:
5044:
5029:
5014:
4999:
4984:
4969:
4954:
4939:
4924:
4909:
4894:
4879:
4864:
4849:
4834:
4819:
4804:
4789:
4774:
4759:
4744:
4729:
4714:
4699:
4684:
4669:
4654:
4639:
4624:
4609:
4594:
4579:
4564:
4549:
4534:
4519:
4504:
4489:
4474:
4459:
4444:
4429:
4414:
4399:
4384:
4369:
4354:
4339:
4324:
4309:
4294:
4279:
4264:
4249:
4234:
4219:
4204:
4189:
4174:
4159:
4144:
4129:
4114:
4099:
4079:
4072:
4065:
4056:
4038:
4008:
3979:
3969:
3959:
3926:
3909:(37): 11205–15.
3897:
3887:
3877:
3844:
3834:
3811:The EMBO Journal
3801:
3784:(39): 12778–87.
3772:
3755:(39): 12762–77.
3743:
3726:(39): 12742–61.
3713:
3684:
3647:
3618:
3608:
3575:
3538:
3509:
3499:
3474:
3464:
3431:
3398:
3388:
3363:
3342:
3332:
3290:
3289:
3261:
3255:
3254:
3244:
3221:The EMBO Journal
3212:
3206:
3205:
3195:
3163:
3157:
3156:
3120:
3114:
3113:
3095:
3071:
3065:
3064:
3054:
3037:(16): 5499–510.
3022:
3016:
3015:
3005:
2996:(31): 18508–13.
2981:
2975:
2974:
2937:
2931:
2930:
2920:
2896:
2890:
2889:
2852:
2846:
2845:
2825:
2819:
2818:
2808:
2798:
2781:(21): 12586–90.
2766:
2760:
2759:
2741:
2735:
2734:
2724:
2692:
2683:
2682:
2663:10.1038/243441a0
2638:
2632:
2631:
2595:
2586:
2585:
2575:
2543:
2534:
2533:
2526:
2517:
2516:
2505:
2499:
2498:
2487:
2481:
2471:
2273:released during
2215:, also known as
2070:
2058:
2038:
2037:
2009:
2002:
1987:
1975:
1966:
1954:
1950:RefSeq (protein)
1940:
1928:
1919:
1907:
1883:
1864:
1838:
1819:
1793:
1774:
1743:
1453:
1439:
1430:
1423:
1408:
1348:
1346:Top expressed in
1341:
1302:secondary oocyte
1286:
1284:Top expressed in
1279:
1258:
1241:
1231:
1218:
1207:
1192:
1185:
1179:
1168:
1156:
1140:
1134:
1132:POLB - orthologs
1085:
1078:
1055:
66:
60:
39:
38:
33:
21:
6001:
6000:
5996:
5995:
5994:
5992:
5991:
5990:
5961:
5960:
5959:
5954:
5951:
5945:
5936:
5930:
5921:
5915:
5906:
5900:
5891:
5885:
5876:
5870:
5861:
5855:
5846:
5840:
5831:
5825:
5816:
5810:
5801:
5795:
5786:
5780:
5771:
5765:
5756:
5750:
5741:
5735:
5726:
5720:
5711:
5705:
5696:
5690:
5681:
5675:
5666:
5660:
5651:
5645:
5636:
5630:
5621:
5615:
5606:
5600:
5591:
5585:
5576:
5570:
5561:
5555:
5546:
5540:
5531:
5525:
5516:
5510:
5501:
5495:
5486:
5480:
5471:
5465:
5456:
5450:
5441:
5435:
5426:
5420:
5411:
5405:
5396:
5390:
5381:
5375:
5366:
5360:
5351:
5345:
5336:
5330:
5321:
5315:
5306:
5300:
5291:
5285:
5276:
5270:
5261:
5255:
5246:
5240:
5231:
5225:
5216:
5210:
5201:
5195:
5186:
5180:
5171:
5165:
5156:
5150:
5141:
5135:
5126:
5120:
5111:
5105:
5096:
5090:
5081:
5075:
5066:
5060:
5051:
5045:
5036:
5030:
5021:
5015:
5006:
5000:
4991:
4985:
4976:
4970:
4961:
4955:
4946:
4940:
4931:
4925:
4916:
4910:
4901:
4895:
4886:
4880:
4871:
4865:
4856:
4850:
4841:
4835:
4826:
4820:
4811:
4805:
4796:
4790:
4781:
4775:
4766:
4760:
4751:
4745:
4736:
4730:
4721:
4715:
4706:
4700:
4691:
4685:
4676:
4670:
4661:
4655:
4646:
4640:
4631:
4625:
4616:
4610:
4601:
4595:
4586:
4580:
4571:
4565:
4556:
4550:
4541:
4535:
4526:
4520:
4511:
4505:
4496:
4490:
4481:
4475:
4466:
4460:
4451:
4445:
4436:
4430:
4421:
4415:
4406:
4400:
4391:
4385:
4376:
4370:
4361:
4355:
4346:
4340:
4331:
4325:
4316:
4310:
4301:
4295:
4286:
4280:
4271:
4265:
4256:
4250:
4241:
4235:
4226:
4220:
4211:
4205:
4196:
4190:
4181:
4175:
4166:
4160:
4151:
4145:
4136:
4130:
4121:
4115:
4106:
4100:
4086:
4083:
4046:
4041:
4011:
3991:(1–2): 149–56.
3982:
3942:(19): 10324–9.
3929:
3900:
3847:
3817:(23): 6662–70.
3804:
3775:
3746:
3716:
3687:
3650:
3621:
3591:(14): 2719–25.
3578:
3541:
3512:
3490:(32): 16992–8.
3477:
3447:(20): 9587–96.
3434:
3401:
3379:(17): 10820–4.
3366:
3348:Cancer Research
3345:
3315:(18): 4859–64.
3302:
3298:
3296:Further reading
3293:
3272:(30): 9005–13.
3263:
3262:
3258:
3227:(23): 6662–70.
3214:
3213:
3209:
3178:(7): 2193–201.
3165:
3164:
3160:
3125:Cancer Research
3122:
3121:
3117:
3073:
3072:
3068:
3024:
3023:
3019:
2983:
2982:
2978:
2939:
2938:
2934:
2898:
2897:
2893:
2854:
2853:
2849:
2830:Cancer Research
2827:
2826:
2822:
2768:
2767:
2763:
2756:
2743:
2742:
2738:
2707:(1–2): 135–45.
2694:
2693:
2686:
2649:(5408): 441–5.
2640:
2639:
2635:
2597:
2596:
2589:
2545:
2544:
2537:
2528:
2527:
2520:
2507:
2506:
2502:
2489:
2488:
2484:
2472:
2463:
2459:
2442:
2422:
2394:polyadenylation
2351:
2310:
2294:DNA replication
2271:oxygen radicals
2240:
2073:
2047:View/Edit Mouse
2042:View/Edit Human
2005:
2000:
1997:Location (UCSC)
1983:
1962:
1936:
1915:
1828:ENSG00000070501
1721:
1652:DNA replication
1575:
1534:
1500:protein binding
1435:
1404:
1395:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1344:
1333:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1282:
1226:
1213:
1205:
1195:
1194:
1193:
1186:
1166:
1143:Gene location (
1094:
1081:
1074:
75:
53:
19:
12:
11:
5:
5999:
5997:
5989:
5988:
5983:
5978:
5973:
5963:
5962:
5956:
5955:
5953:
5952:
5946:
5939:
5937:
5931:
5924:
5922:
5916:
5909:
5907:
5901:
5894:
5892:
5886:
5879:
5877:
5871:
5864:
5862:
5856:
5849:
5847:
5841:
5834:
5832:
5826:
5819:
5817:
5811:
5804:
5802:
5796:
5789:
5787:
5781:
5774:
5772:
5766:
5759:
5757:
5751:
5744:
5742:
5736:
5729:
5727:
5721:
5714:
5712:
5706:
5699:
5697:
5691:
5684:
5682:
5676:
5669:
5667:
5661:
5654:
5652:
5646:
5639:
5637:
5631:
5624:
5622:
5616:
5609:
5607:
5601:
5594:
5592:
5586:
5579:
5577:
5571:
5564:
5562:
5556:
5549:
5547:
5541:
5534:
5532:
5526:
5519:
5517:
5511:
5504:
5502:
5496:
5489:
5487:
5481:
5474:
5472:
5466:
5459:
5457:
5451:
5444:
5442:
5436:
5429:
5427:
5421:
5414:
5412:
5406:
5399:
5397:
5391:
5384:
5382:
5376:
5369:
5367:
5361:
5354:
5352:
5346:
5339:
5337:
5331:
5324:
5322:
5316:
5309:
5307:
5301:
5294:
5292:
5286:
5279:
5277:
5271:
5264:
5262:
5256:
5249:
5247:
5241:
5234:
5232:
5226:
5219:
5217:
5211:
5204:
5202:
5196:
5189:
5187:
5181:
5174:
5172:
5166:
5159:
5157:
5151:
5144:
5142:
5136:
5129:
5127:
5121:
5114:
5112:
5106:
5099:
5097:
5091:
5084:
5082:
5076:
5069:
5067:
5061:
5054:
5052:
5046:
5039:
5037:
5031:
5024:
5022:
5016:
5009:
5007:
5001:
4994:
4992:
4986:
4979:
4977:
4971:
4964:
4962:
4956:
4949:
4947:
4941:
4934:
4932:
4926:
4919:
4917:
4911:
4904:
4902:
4896:
4889:
4887:
4881:
4874:
4872:
4866:
4859:
4857:
4851:
4844:
4842:
4836:
4829:
4827:
4821:
4814:
4812:
4806:
4799:
4797:
4791:
4784:
4782:
4776:
4769:
4767:
4761:
4754:
4752:
4746:
4739:
4737:
4731:
4724:
4722:
4716:
4709:
4707:
4701:
4694:
4692:
4686:
4679:
4677:
4671:
4664:
4662:
4656:
4649:
4647:
4641:
4634:
4632:
4626:
4619:
4617:
4611:
4604:
4602:
4596:
4589:
4587:
4581:
4574:
4572:
4566:
4559:
4557:
4551:
4544:
4542:
4536:
4529:
4527:
4521:
4514:
4512:
4506:
4499:
4497:
4491:
4484:
4482:
4476:
4469:
4467:
4461:
4454:
4452:
4446:
4439:
4437:
4431:
4424:
4422:
4416:
4409:
4407:
4401:
4394:
4392:
4386:
4379:
4377:
4371:
4364:
4362:
4356:
4349:
4347:
4341:
4334:
4332:
4326:
4319:
4317:
4311:
4304:
4302:
4296:
4289:
4287:
4281:
4274:
4272:
4266:
4259:
4257:
4251:
4244:
4242:
4236:
4229:
4227:
4221:
4214:
4212:
4206:
4199:
4197:
4191:
4184:
4182:
4176:
4169:
4167:
4161:
4154:
4152:
4146:
4139:
4137:
4131:
4124:
4122:
4116:
4109:
4107:
4101:
4094:
4091:
4088:
4087:
4084:
4082:
4081:
4074:
4067:
4059:
4053:
4052:
4045:
4044:External links
4042:
4040:
4039:
4015:Cancer Letters
4009:
3980:
3927:
3898:
3860:(14): 7166–9.
3845:
3802:
3773:
3744:
3714:
3685:
3653:Human Genetics
3648:
3630:(1–2): 171–4.
3619:
3576:
3544:Human Genetics
3539:
3510:
3475:
3432:
3399:
3364:
3354:(17): 4824–7.
3343:
3299:
3297:
3294:
3292:
3291:
3256:
3207:
3158:
3131:(21): 7673–7.
3115:
3066:
3017:
2976:
2932:
2911:(6): 1049–54.
2905:Carcinogenesis
2891:
2864:(43): 6181–7.
2847:
2836:(12): 3511–4.
2820:
2761:
2754:
2736:
2684:
2633:
2587:
2535:
2518:
2500:
2482:
2460:
2458:
2455:
2454:
2453:
2448:
2441:
2438:
2421:
2418:
2350:
2347:
2309:
2306:
2275:ATP production
2239:
2236:
2208:
2207:
2202:
2195:
2194:
2184:
2178:
2177:
2172:
2166:
2165:
2160:
2153:
2152:
2148:
2147:
2142:
2136:
2135:
2130:
2124:
2123:
2118:
2112:
2111:
2106:
2100:
2099:
2094:
2088:
2087:
2084:
2080:
2079:
2075:
2074:
2071:
2063:
2062:
2054:
2053:
2050:
2049:
2044:
2034:
2033:
2027:
2026:
2023:
2022:
2020:
2018:
2011:
2010:
2003:
1998:
1994:
1993:
1990:
1989:
1979:
1978:
1972:
1969:
1968:
1958:
1957:
1951:
1947:
1946:
1943:
1942:
1932:
1931:
1925:
1922:
1921:
1911:
1910:
1904:
1900:
1899:
1896:
1895:
1887:
1886:
1880:
1877:
1876:
1868:
1867:
1861:
1855:
1854:
1851:
1850:
1842:
1841:
1835:
1832:
1831:
1823:
1822:
1816:
1810:
1809:
1806:
1805:
1797:
1796:
1790:
1787:
1786:
1778:
1777:
1771:
1765:
1764:
1759:
1754:
1750:
1749:
1739:
1738:
1735:
1734:
1723:
1722:
1720:
1719:
1714:
1709:
1704:
1699:
1694:
1689:
1684:
1679:
1674:
1669:
1664:
1659:
1654:
1649:
1644:
1639:
1634:
1629:
1624:
1619:
1614:
1609:
1604:
1599:
1594:
1589:
1583:
1581:
1577:
1576:
1574:
1573:
1568:
1563:
1558:
1553:
1548:
1542:
1540:
1536:
1535:
1533:
1532:
1527:
1525:DNA polymerase
1522:
1517:
1512:
1510:enzyme binding
1507:
1505:lyase activity
1502:
1497:
1492:
1487:
1482:
1477:
1472:
1466:
1464:
1460:
1459:
1449:
1448:
1445:
1444:
1441:
1440:
1432:
1431:
1420:
1414:
1413:
1410:
1409:
1401:
1400:
1397:
1396:
1394:
1393:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1350:
1349:
1338:
1335:
1334:
1332:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1288:
1287:
1275:
1274:
1266:
1255:
1249:
1248:
1245:RNA expression
1237:
1236:
1233:
1232:
1224:
1220:
1219:
1211:
1208:
1203:
1197:
1196:
1187:
1180:
1174:
1170:
1169:
1164:
1158:
1157:
1149:
1148:
1136:
1135:
1092:
1088:
1087:
1079:
1071:
1070:
1066:
1065:
1062:
1061:
1058:
1057:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
5998:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5968:
5966:
5949:
5943:
5938:
5934:
5928:
5923:
5919:
5913:
5908:
5904:
5898:
5893:
5889:
5883:
5878:
5874:
5868:
5863:
5859:
5853:
5848:
5844:
5838:
5833:
5829:
5823:
5818:
5814:
5808:
5803:
5799:
5793:
5788:
5784:
5778:
5773:
5769:
5763:
5758:
5754:
5748:
5743:
5739:
5733:
5728:
5724:
5718:
5713:
5709:
5703:
5698:
5694:
5688:
5683:
5679:
5673:
5668:
5664:
5658:
5653:
5649:
5643:
5638:
5634:
5628:
5623:
5619:
5613:
5608:
5604:
5598:
5593:
5589:
5583:
5578:
5574:
5568:
5563:
5559:
5553:
5548:
5544:
5538:
5533:
5529:
5523:
5518:
5514:
5508:
5503:
5499:
5493:
5488:
5484:
5478:
5473:
5469:
5463:
5458:
5454:
5448:
5443:
5439:
5433:
5428:
5424:
5418:
5413:
5409:
5403:
5398:
5394:
5388:
5383:
5379:
5373:
5368:
5364:
5358:
5353:
5349:
5343:
5338:
5334:
5328:
5323:
5319:
5313:
5308:
5304:
5298:
5293:
5289:
5283:
5278:
5274:
5268:
5263:
5259:
5253:
5248:
5244:
5238:
5233:
5229:
5223:
5218:
5214:
5208:
5203:
5199:
5193:
5188:
5184:
5178:
5173:
5169:
5163:
5158:
5154:
5148:
5143:
5139:
5133:
5128:
5124:
5118:
5113:
5109:
5103:
5098:
5094:
5088:
5083:
5079:
5073:
5068:
5064:
5058:
5053:
5049:
5043:
5038:
5034:
5028:
5023:
5019:
5013:
5008:
5004:
4998:
4993:
4989:
4983:
4978:
4974:
4968:
4963:
4959:
4953:
4948:
4944:
4938:
4933:
4929:
4923:
4918:
4914:
4908:
4903:
4899:
4893:
4888:
4884:
4878:
4873:
4869:
4863:
4858:
4854:
4848:
4843:
4839:
4833:
4828:
4824:
4818:
4813:
4809:
4803:
4798:
4794:
4788:
4783:
4779:
4773:
4768:
4764:
4758:
4753:
4749:
4743:
4738:
4734:
4728:
4723:
4719:
4713:
4708:
4704:
4698:
4693:
4689:
4683:
4678:
4674:
4668:
4663:
4659:
4653:
4648:
4644:
4638:
4633:
4629:
4623:
4618:
4614:
4608:
4603:
4599:
4593:
4588:
4584:
4578:
4573:
4569:
4563:
4558:
4554:
4548:
4543:
4539:
4533:
4528:
4524:
4518:
4513:
4509:
4503:
4498:
4494:
4488:
4483:
4479:
4473:
4468:
4464:
4458:
4453:
4449:
4443:
4438:
4434:
4428:
4423:
4419:
4413:
4408:
4404:
4398:
4393:
4389:
4383:
4378:
4374:
4368:
4363:
4359:
4353:
4348:
4344:
4338:
4333:
4329:
4323:
4318:
4314:
4308:
4303:
4299:
4293:
4288:
4284:
4278:
4273:
4269:
4263:
4258:
4254:
4248:
4243:
4239:
4233:
4228:
4224:
4218:
4213:
4209:
4203:
4198:
4194:
4188:
4183:
4179:
4173:
4168:
4164:
4158:
4153:
4149:
4143:
4138:
4134:
4128:
4123:
4119:
4113:
4108:
4104:
4098:
4093:
4089:
4080:
4075:
4073:
4068:
4066:
4061:
4060:
4057:
4051:
4048:
4047:
4043:
4036:
4032:
4028:
4024:
4021:(1): 101–14.
4020:
4016:
4010:
4006:
4002:
3998:
3994:
3990:
3986:
3981:
3977:
3973:
3968:
3963:
3958:
3953:
3949:
3945:
3941:
3937:
3933:
3928:
3924:
3920:
3916:
3912:
3908:
3904:
3899:
3895:
3891:
3886:
3881:
3876:
3871:
3867:
3863:
3859:
3855:
3851:
3846:
3842:
3838:
3833:
3828:
3824:
3820:
3816:
3812:
3808:
3803:
3799:
3795:
3791:
3787:
3783:
3779:
3774:
3770:
3766:
3762:
3758:
3754:
3750:
3745:
3741:
3737:
3733:
3729:
3725:
3721:
3715:
3711:
3707:
3703:
3699:
3695:
3691:
3686:
3682:
3678:
3674:
3670:
3666:
3662:
3659:(5): 507–12.
3658:
3654:
3649:
3645:
3641:
3637:
3633:
3629:
3625:
3620:
3616:
3612:
3607:
3602:
3598:
3594:
3590:
3586:
3582:
3577:
3573:
3569:
3565:
3561:
3557:
3553:
3550:(4): 389–90.
3549:
3545:
3540:
3536:
3532:
3528:
3524:
3520:
3516:
3511:
3507:
3503:
3498:
3493:
3489:
3485:
3481:
3476:
3472:
3468:
3463:
3458:
3454:
3450:
3446:
3442:
3438:
3433:
3429:
3425:
3421:
3417:
3413:
3409:
3405:
3400:
3396:
3392:
3387:
3382:
3378:
3374:
3370:
3365:
3361:
3357:
3353:
3349:
3344:
3340:
3336:
3331:
3326:
3322:
3318:
3314:
3310:
3306:
3301:
3300:
3295:
3287:
3283:
3279:
3275:
3271:
3267:
3260:
3257:
3252:
3248:
3243:
3238:
3234:
3230:
3226:
3222:
3218:
3211:
3208:
3203:
3199:
3194:
3189:
3185:
3181:
3177:
3173:
3169:
3162:
3159:
3154:
3150:
3146:
3142:
3138:
3134:
3130:
3126:
3119:
3116:
3111:
3107:
3103:
3099:
3094:
3089:
3086:(1): 107–17.
3085:
3081:
3077:
3070:
3067:
3062:
3058:
3053:
3048:
3044:
3040:
3036:
3032:
3028:
3021:
3018:
3013:
3009:
3004:
2999:
2995:
2991:
2987:
2980:
2977:
2972:
2968:
2964:
2960:
2956:
2952:
2948:
2944:
2936:
2933:
2928:
2924:
2919:
2914:
2910:
2906:
2902:
2895:
2892:
2887:
2883:
2879:
2875:
2871:
2867:
2863:
2859:
2851:
2848:
2843:
2839:
2835:
2831:
2824:
2821:
2816:
2812:
2807:
2802:
2797:
2792:
2788:
2784:
2780:
2776:
2772:
2765:
2762:
2757:
2755:0-12-092860-4
2751:
2747:
2740:
2737:
2732:
2728:
2723:
2718:
2714:
2710:
2706:
2702:
2698:
2691:
2689:
2685:
2680:
2676:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2634:
2629:
2625:
2621:
2617:
2613:
2609:
2606:(4): 1273–8.
2605:
2601:
2594:
2592:
2588:
2583:
2579:
2574:
2569:
2565:
2561:
2557:
2553:
2549:
2542:
2540:
2536:
2531:
2525:
2523:
2519:
2514:
2510:
2504:
2501:
2496:
2492:
2486:
2483:
2479:
2475:
2470:
2468:
2466:
2462:
2456:
2452:
2449:
2447:
2444:
2443:
2439:
2437:
2435:
2431:
2427:
2419:
2417:
2414:
2410:
2406:
2401:
2399:
2395:
2390:
2386:
2382:
2378:
2375:
2370:
2368:
2364:
2360:
2356:
2348:
2346:
2343:
2342:messenger RNA
2339:
2335:
2331:
2327:
2323:
2319:
2315:
2307:
2305:
2303:
2299:
2295:
2290:
2288:
2284:
2280:
2276:
2272:
2268:
2263:
2261:
2260:recombination
2257:
2254:maintenance,
2253:
2249:
2245:
2237:
2235:
2233:
2230:
2226:
2222:
2218:
2214:
2206:
2203:
2200:
2196:
2193:
2192:
2188:
2185:
2183:
2179:
2176:
2173:
2171:
2167:
2164:
2161:
2158:
2154:
2149:
2146:
2143:
2141:
2137:
2134:
2131:
2129:
2125:
2122:
2119:
2117:
2113:
2110:
2107:
2105:
2101:
2098:
2095:
2093:
2089:
2085:
2081:
2076:
2069:
2064:
2059:
2048:
2043:
2039:
2035:
2032:
2028:
2021:
2019:
2016:
2012:
2008:
2004:
1999:
1995:
1988:
1986:
1980:
1976:
1973:
1967:
1965:
1959:
1955:
1952:
1948:
1941:
1939:
1933:
1929:
1926:
1920:
1918:
1912:
1908:
1905:
1903:RefSeq (mRNA)
1901:
1894:
1893:
1888:
1884:
1881:
1875:
1874:
1869:
1865:
1862:
1860:
1856:
1849:
1848:
1843:
1839:
1836:
1830:
1829:
1824:
1820:
1817:
1815:
1811:
1804:
1803:
1798:
1794:
1791:
1785:
1784:
1779:
1775:
1772:
1770:
1766:
1763:
1760:
1758:
1755:
1751:
1748:
1744:
1740:
1733:
1729:
1724:
1718:
1715:
1713:
1710:
1708:
1705:
1703:
1700:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1678:
1675:
1673:
1670:
1668:
1665:
1663:
1660:
1658:
1655:
1653:
1650:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1615:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1584:
1582:
1579:
1578:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1543:
1541:
1538:
1537:
1531:
1528:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1467:
1465:
1462:
1461:
1458:
1457:Gene ontology
1454:
1450:
1438:
1433:
1429:
1424:
1421:
1419:
1415:
1407:
1402:
1391:
1387:
1383:
1379:
1376:hair follicle
1375:
1371:
1367:
1363:
1359:
1355:
1354:
1351:
1347:
1342:
1339:
1329:
1325:
1322:parotid gland
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1292:
1289:
1285:
1280:
1277:
1276:
1273:
1271:
1267:
1265:
1264:
1260:
1259:
1256:
1254:
1250:
1246:
1242:
1238:
1230:
1225:
1221:
1217:
1212:
1202:
1198:
1191:
1184:
1178:
1171:
1163:
1159:
1155:
1150:
1146:
1141:
1137:
1133:
1129:
1125:
1121:
1117:
1113:
1109:
1105:
1101:
1097:
1089:
1084:
1077:
1072:
1067:
1056:
1054:
1050:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
986:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
882:
878:
874:
870:
866:
862:
858:
854:
850:
846:
842:
838:
834:
830:
826:
822:
818:
814:
810:
806:
802:
798:
794:
790:
786:
782:
778:
774:
770:
766:
762:
758:
754:
750:
746:
742:
738:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
694:
690:
686:
682:
678:
674:
670:
666:
662:
658:
654:
650:
646:
642:
638:
634:
630:
626:
622:
618:
614:
610:
606:
602:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
5947:
5932:
5917:
5902:
5887:
5872:
5857:
5842:
5827:
5812:
5797:
5782:
5767:
5752:
5737:
5722:
5707:
5692:
5677:
5662:
5647:
5632:
5617:
5602:
5587:
5572:
5557:
5542:
5527:
5512:
5497:
5482:
5467:
5452:
5437:
5422:
5407:
5392:
5377:
5362:
5347:
5332:
5317:
5302:
5287:
5272:
5257:
5242:
5227:
5212:
5197:
5182:
5167:
5152:
5137:
5122:
5107:
5092:
5077:
5062:
5047:
5032:
5017:
5002:
4987:
4972:
4957:
4942:
4927:
4912:
4897:
4882:
4867:
4852:
4837:
4822:
4807:
4792:
4777:
4762:
4747:
4732:
4717:
4702:
4687:
4672:
4657:
4642:
4627:
4612:
4597:
4582:
4567:
4552:
4537:
4522:
4507:
4492:
4477:
4462:
4447:
4432:
4417:
4402:
4387:
4372:
4357:
4342:
4327:
4312:
4297:
4282:
4267:
4252:
4237:
4222:
4207:
4192:
4177:
4162:
4147:
4132:
4117:
4102:
4018:
4014:
3988:
3984:
3939:
3935:
3906:
3903:Biochemistry
3902:
3857:
3853:
3814:
3810:
3781:
3778:Biochemistry
3777:
3752:
3749:Biochemistry
3748:
3723:
3720:Biochemistry
3719:
3696:(8): 653–9.
3693:
3689:
3656:
3652:
3627:
3623:
3588:
3584:
3547:
3543:
3521:(3): 901–9.
3518:
3515:Biochemistry
3514:
3487:
3483:
3444:
3440:
3414:(1): 341–7.
3411:
3407:
3376:
3372:
3351:
3347:
3312:
3308:
3269:
3266:Biochemistry
3265:
3259:
3224:
3220:
3210:
3175:
3171:
3161:
3128:
3124:
3118:
3083:
3079:
3069:
3034:
3030:
3020:
2993:
2989:
2979:
2949:(1): 19–23.
2946:
2942:
2935:
2908:
2904:
2894:
2861:
2857:
2850:
2833:
2829:
2823:
2778:
2774:
2764:
2745:
2739:
2704:
2700:
2646:
2642:
2636:
2603:
2599:
2555:
2551:
2512:
2503:
2494:
2485:
2423:
2420:Interactions
2409:trans-acting
2402:
2371:
2352:
2311:
2291:
2264:
2241:
2228:
2216:
2212:
2211:
2189:
1982:
1961:
1935:
1914:
1890:
1871:
1845:
1826:
1800:
1781:
1761:
1756:
1627:human ageing
1360:spermatocyte
1268:
1261:
1091:External IDs
74:
15:
5971:Human genes
4085:PDB gallery
2256:replication
2223:present in
2078:Identifiers
1561:microtubule
1551:nucleoplasm
1475:DNA binding
1227:23,143,451
1214:23,118,142
1069:Identifiers
5981:DNA repair
5965:Categories
2552:DNA Repair
2480:, May 2017
2457:References
2365:, induced
2244:eukaryotic
2225:eukaryotes
2201:structures
2151:Other data
1692:DNA repair
1272:(ortholog)
1112:HomoloGene
2558:: 77–88.
2411:protein,
2389:stem-loop
2367:apoptosis
2170:Domain(s)
2145:NM_002690
2104:NCBI Gene
1985:NP_035260
1964:NP_002681
1938:NM_011130
1917:NM_002690
1747:Orthologs
1546:cytoplasm
1356:spermatid
1120:GeneCards
4035:15737693
3681:34824853
3572:22658070
3286:11467963
3202:15107487
3153:35569215
3145:15520167
3102:11163244
3061:17704138
2971:33798724
2963:12674496
2927:10357787
2886:30039904
2878:11593426
2858:Oncogene
2842:12067997
2731:11890943
2628:84448241
2582:29100041
2476:–
2440:See also
2426:interact
2238:Function
2219:, is an
2175:Mammalia
2031:Wikidata
1726:Sources:
1326:monocyte
4005:9373149
3976:9294209
3944:Bibcode
3923:9287163
3894:9207062
3862:Bibcode
3841:8978692
3798:8841120
3769:8841119
3740:8841118
3710:8769567
3673:8168825
3644:8125298
3615:7914364
3564:7705833
3535:3284575
3506:3182828
3471:2460824
3428:2423078
3395:2040602
3360:1511447
3339:1408801
3251:8978692
3110:1487128
3052:2018635
3012:8702497
2815:9770529
2783:Bibcode
2722:3339152
2679:4153800
2671:4591306
2651:Bibcode
2620:3161998
2573:5919216
2478:Ensembl
2338:protein
2316:by the
2298:neurons
2163:Cis-reg
2097:RF01455
1859:UniProt
1814:Ensembl
1753:Species
1732:QuickGO
1566:nucleus
1247:pattern
1076:Aliases
4033:
4003:
3974:
3964:
3921:
3892:
3882:
3839:
3832:452490
3829:
3796:
3767:
3738:
3708:
3679:
3671:
3642:
3613:
3606:308239
3603:
3570:
3562:
3533:
3504:
3469:
3462:338765
3459:
3426:
3393:
3358:
3337:
3330:334243
3327:
3284:
3249:
3242:452490
3239:
3200:
3193:407833
3190:
3151:
3143:
3108:
3100:
3059:
3049:
3010:
2969:
2961:
2925:
2884:
2876:
2840:
2813:
2803:
2752:
2729:
2719:
2677:
2669:
2643:Nature
2626:
2618:
2580:
2570:
2334:testes
2330:spleen
2287:genome
2221:enzyme
2187:Chr. 8
2140:RefSeq
2133:174760
2083:Symbol
2017:search
2015:PubMed
1892:Q8K409
1873:P06746
1769:Entrez
1418:BioGPS
1294:oocyte
1100:174760
3967:23361
3885:23779
3677:S2CID
3568:S2CID
3149:S2CID
3106:S2CID
2967:S2CID
2882:S2CID
2806:22874
2675:S2CID
2624:S2CID
2451:POLA2
2446:POLA1
2434:XRCC1
2428:with
2374:CREB1
2326:liver
2322:brain
2302:aging
2191:p11.2
2182:Locus
1802:18970
1762:Mouse
1757:Human
1728:Amigo
1392:fossa
1306:sperm
1270:Mouse
1263:Human
1210:Start
1145:Mouse
1108:97740
5948:9icy
5933:9icx
5918:9icw
5903:9icv
5888:9icu
5873:9ict
5858:9ics
5843:9icr
5828:9icq
5813:9icp
5798:9ico
5783:9icn
5768:9icm
5753:9icl
5738:9ick
5723:9icj
5708:9ici
5693:9ich
5678:9icg
5663:9icf
5648:9ice
5633:9icc
5618:9icb
5603:9ica
5588:8icz
5573:8icy
5558:8icx
5543:8icw
5528:8icv
5513:8icu
5498:8ict
5483:8ics
5468:8icr
5453:8icq
5438:8icp
5423:8ico
5408:8icn
5393:8icm
5378:8icl
5363:8ick
5348:8icj
5333:8ici
5318:8ich
5303:8icg
5288:8icf
5273:8ice
5258:8icc
5243:8icb
5228:8ica
5213:7icv
5198:7icu
5183:7ict
5168:7ics
5153:7icr
5138:7icq
5123:7icp
5108:7ico
5093:7icn
5078:7icm
5063:7icl
5048:7ick
5033:7icj
5018:7ici
5003:7ich
4988:7icg
4973:7icf
4958:7ice
4943:2p66
4928:2isp
4913:2iso
4898:2i9g
4883:2fms
4868:2fmq
4853:2fmp
4838:2bpg
4823:2bpf
4808:2bpc
4793:1zqz
4778:1zqy
4763:1zqx
4748:1zqw
4733:1zqv
4718:1zqu
4703:1zqt
4688:1zqs
4673:1zqr
4658:1zqq
4643:1zqp
4628:1zqo
4613:1zqn
4598:1zqm
4583:1zql
4568:1zqk
4553:1zqj
4538:1zqi
4523:1zqh
4508:1zqg
4493:1zqf
4478:1zqe
4463:1zqd
4448:1zqc
4433:1zqb
4418:1zqa
4403:1zjn
4388:1zjm
4373:1tva
4358:1tv9
4343:1rpl
4328:1nom
4313:1mq3
4298:1mq2
4283:1jn3
4268:1huz
4253:1huo
4238:1dk3
4223:1dk2
4208:1bpz
4193:1bpy
4178:1bpx
4163:1bpe
4148:1bpd
4133:1bpb
4118:1bnp
4103:1bno
4031:PMID
4001:PMID
3985:Gene
3972:PMID
3919:PMID
3890:PMID
3837:PMID
3794:PMID
3765:PMID
3736:PMID
3706:PMID
3669:PMID
3640:PMID
3624:Gene
3611:PMID
3560:PMID
3531:PMID
3502:PMID
3467:PMID
3424:PMID
3391:PMID
3356:PMID
3335:PMID
3282:PMID
3247:PMID
3198:PMID
3141:PMID
3098:PMID
3080:Cell
3057:PMID
3008:PMID
2959:PMID
2923:PMID
2874:PMID
2838:PMID
2811:PMID
2750:ISBN
2727:PMID
2667:PMID
2616:PMID
2578:PMID
2432:and
2430:PNKP
2413:HAX1
2359:mRNA
2340:and
2332:and
2265:The
2232:gene
2229:POLB
2217:POLB
2205:PDBe
2159:type
2128:OMIM
2121:9174
2116:HGNC
2109:5423
2092:Rfam
2086:POLB
1783:5423
1330:pons
1253:Bgee
1201:Band
1162:Chr.
1124:POLB
1116:2013
1096:OMIM
1083:POLB
1053:4Z6E
1049:4Z6D
1045:4Z6F
1041:4Z6C
1037:4YMM
1033:4YMO
1029:4YN4
1025:4YMN
1021:5DB6
1017:5DB9
1013:5DBC
1009:5DB7
1005:5DBA
1001:5DBB
997:5DB8
993:5BPC
989:5BOM
985:5BOL
981:9ICY
977:9ICX
973:9ICW
969:9ICV
965:9ICU
961:9ICT
957:9ICS
953:9ICR
949:9ICQ
945:9ICP
941:9ICO
937:9ICN
933:9ICM
929:9ICL
925:9ICK
921:9ICJ
917:9ICI
913:9ICH
909:9ICG
905:9ICF
901:9ICE
897:9ICC
893:9ICB
889:9ICA
885:8ICZ
881:8ICY
877:8ICX
873:8ICW
869:8ICV
865:8ICU
861:8ICT
857:8ICS
853:8ICR
849:8ICQ
845:8ICP
841:8ICO
837:8ICN
833:8ICM
829:8ICL
825:8ICK
821:8ICJ
817:8ICI
813:8ICH
809:8ICG
805:8ICF
801:8ICE
797:8ICC
793:8ICB
789:8ICA
785:7ICV
781:7ICU
777:7ICT
773:7ICS
769:7ICR
765:7ICQ
761:7ICP
757:7ICO
753:7ICN
749:7ICM
745:7ICL
741:7ICK
737:7ICJ
733:7ICI
729:7ICH
725:7ICG
721:7ICF
717:7ICE
713:4UBC
709:4UBB
705:4UB5
701:4UB4
697:4UB3
693:4UB2
689:4UB1
685:4UAZ
681:4UAY
677:4UAW
673:4TUS
669:4TUR
665:4TUQ
661:4TUP
657:4RT3
653:4RT2
649:4RQ8
645:4RQ7
641:4RQ6
637:4RQ5
633:4RQ4
629:4RQ3
625:4RQ2
621:4RQ1
617:4RQ0
613:4RPZ
609:4RPY
605:4RPX
601:4R66
597:4R65
593:4R64
589:4R63
585:4PPX
581:4PHP
577:4PHE
573:4PHD
569:4PHA
565:4PH5
561:4PGY
557:4PGX
553:4PGQ
549:4P2H
545:4O9M
541:4O5K
537:4O5E
533:4O5C
529:4NY8
525:4NXZ
521:4NM2
517:4NM1
513:4NLZ
509:4NLN
505:4NLK
501:4MFF
497:4MFC
493:4MFA
489:4MF8
485:4MF2
481:4M9N
477:4M9L
473:4M9J
469:4M9H
465:4M9G
461:4M47
457:4M2Y
453:4LVS
449:4KLU
445:4KLT
441:4KLS
437:4KLQ
433:4KLO
429:4KLM
425:4KLL
421:4KLJ
417:4KLI
413:4KLH
409:4KLG
405:4KLF
401:4KLE
397:4KLD
393:4JWN
389:4JWM
385:4GXK
381:4GXJ
377:4GXI
373:4F5R
369:4F5Q
365:4F5P
361:4F5O
357:4F5N
353:4DOC
349:4DOB
345:4DOA
341:4DO9
337:3TFS
333:3TFR
329:3RJK
325:3RJJ
321:3RJI
317:3RJH
313:3RJG
309:3RJF
305:3RJE
301:3RH6
297:3RH5
293:3RH4
289:3OGU
285:3MBY
281:3LK9
277:3JPT
273:3JPS
269:3JPR
265:3JPQ
261:3JPP
257:3JPO
253:3JPN
249:3ISD
245:3ISC
241:3ISB
237:3GDX
233:3C2M
229:3C2L
225:3C2K
221:2PXI
217:2P66
213:2ISP
209:2ISO
205:2I9G
201:2FMS
197:2FMQ
193:2FMP
189:1ZQT
185:1ZQS
181:1ZQR
177:1ZQQ
173:1ZQP
169:1ZQO
165:1ZQN
161:1ZQM
157:1ZQL
153:1ZQK
149:1ZQJ
145:1ZQI
141:1ZQH
137:1ZQG
133:1ZQF
129:1ZQE
125:1ZQD
121:1ZQC
117:1ZQB
113:1ZQA
109:1ZJN
105:1ZJM
101:1TVA
97:1TV9
93:1MQ3
89:1MQ2
85:1BPZ
81:1BPY
77:1BPX
58:RCSB
55:PDBe
24:POLB
4023:doi
4019:220
3993:doi
3989:200
3962:PMC
3952:doi
3911:doi
3880:PMC
3870:doi
3827:PMC
3819:doi
3786:doi
3757:doi
3728:doi
3698:doi
3661:doi
3632:doi
3628:138
3601:PMC
3593:doi
3552:doi
3523:doi
3492:doi
3488:263
3457:PMC
3449:doi
3416:doi
3412:136
3381:doi
3377:266
3325:PMC
3317:doi
3274:doi
3237:PMC
3229:doi
3188:PMC
3180:doi
3133:doi
3088:doi
3084:104
3047:PMC
3039:doi
2998:doi
2994:271
2951:doi
2947:384
2913:doi
2866:doi
2801:PMC
2791:doi
2717:PMC
2709:doi
2705:500
2659:doi
2647:243
2608:doi
2568:PMC
2560:doi
2385:UTR
2318:BER
2252:DNA
2242:In
2199:PDB
2157:RNA
2001:n/a
1223:End
1128:OMA
1104:MGI
48:PDB
5967::
4029:.
4017:.
3999:.
3987:.
3970:.
3960:.
3950:.
3940:94
3938:.
3934:.
3917:.
3907:36
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3878:.
3868:.
3858:94
3856:.
3852:.
3835:.
3825:.
3815:15
3813:.
3809:.
3792:.
3782:35
3780:.
3763:.
3753:35
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3724:35
3722:.
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3692:.
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3667:.
3657:93
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3609:.
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3558:.
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3519:27
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3482:.
3465:.
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3445:16
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3422:.
3410:.
3406:.
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3375:.
3371:.
3352:52
3350:.
3333:.
3323:.
3313:20
3311:.
3307:.
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3196:.
3186:.
3176:32
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3147:.
3139:.
3129:64
3127:.
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3096:.
3082:.
3078:.
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3033:.
3029:.
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2965:.
2957:.
2945:.
2921:.
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2907:.
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2880:.
2872:.
2862:20
2860:.
2834:62
2832:.
2809:.
2799:.
2789:.
2779:95
2777:.
2773:.
2725:.
2715:.
2703:.
2699:.
2687:^
2673:.
2665:.
2657:.
2645:.
2622:.
2614:.
2604:45
2602:.
2590:^
2576:.
2566:.
2556:60
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2550:.
2538:^
2521:^
2511:.
2493:.
2464:^
2436:.
2328:,
2324:,
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1730:/
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1126:;
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1118:;
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