710:
687:
584:
609:
2887:
961:
716:
615:
29:
55:
2047:
Skoneczna A, McIn Atyre J, Skoneczny M, Policinska Z, Sledziewska-Gojska E (2007). "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in
Saccharomyces cerevisiae".
1570:
are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in
1747:
Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta".
2886:
2077:
Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta".
2516:
Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A, Garritsen VH, Stary A, Avril MF, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasin A, Lehmann AR (2002).
2307:
Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ (2001). "DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes".
723:
622:
2274:"Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation"
2756:"Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells"
1919:
Cruet-Hennequart S, Gallagher K, SokΓ²l AM, Villalan S, Prendergast AM, Carty MP (2010). "DNA Polymerase Ξ·, a Key
Protein in Translesion Synthesis in Human Cells".
1619:, characterized by sun sensitivity, elevated incidence of skin cancer, and at the cellular level, by delayed replication and hypermutability after UV-irradiation
2571:"Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts"
2196:"Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta"
2908:
1234:
545:
2465:"UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization"
1215:
1884:
Stary A, Sarasin A (September 2002). "Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells".
1554:. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.
2866:
1936:
1712:
1694:
1603:
triggers a switch to translesion synthesis by DNA polymerase eta. This polymerase replicates 8-oxoguanine with an accuracy (insertion of a
1566:. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when
2928:
2635:"The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant"
709:
2604:
Kusumoto R, Masutani C, Iwai S, Hanaoka F (2002). "Translesion synthesis by human DNA polymerase eta across thymine glycol lesions".
1607:
opposite the 8-oxoguanine) of approximately 94%. Replication of 8-oxoguanine in the absence of DNA polymerase eta is less than 40%.
1465:
1458:
686:
1733:
1681:
1660:
1798:
Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum".
2239:"Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene"
1677:
608:
583:
52:
2938:
2122:
Johnson RE, Kondratick CM, Prakash S, Prakash L (1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum".
1656:
525:
1628:
2713:"Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links"
722:
621:
2791:"Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells"
2670:"Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells"
2859:
715:
614:
2933:
2016:"The steady-state level and stability of TLS polymerase eta are cellcycle dependent in the yeast S. cerevisiae"
1589:
1279:
533:
2789:
Kannouche P, FernΓ‘ndez de
Henestrosa AR, Coull B, Vidal AE, Gray C, Zicha D, Woodgate R, Lehmann AR (2003).
2668:
Kannouche P, FernΓ‘ndez de
Henestrosa AR, Coull B, Vidal AE, Gray C, Zicha D, Woodgate R, Lehmann AR (2002).
1260:
2895:: Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta
1616:
1551:
2839:
2852:
2529:
2476:
2086:
1756:
597:
512:
2569:
Chiapperino D, Kroth H, Kramarczuk IH, Sayer JM, Masutani C, Hanaoka F, Jerina DM, Cheh AM (2002).
2015:
1441:
1412:
1408:
1382:
1353:
1349:
2518:"Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients"
2332:
2110:
1780:
557:
1437:
1416:
1378:
1357:
2820:
2777:
2742:
2699:
2656:
2621:
2592:
2557:
2504:
2451:
2408:
2365:
2324:
2295:
2260:
2225:
2182:
2139:
2102:
2065:
2035:
1991:
1942:
1932:
1901:
1866:
1815:
1772:
505:
45:
2810:
2802:
2767:
2732:
2724:
2689:
2681:
2646:
2613:
2582:
2547:
2537:
2494:
2484:
2441:
2433:
2398:
2390:
2357:
2316:
2285:
2250:
2215:
2207:
2172:
2164:
2131:
2094:
2057:
2027:
1981:
1973:
1960:
Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S (November 2001).
1924:
1893:
1856:
1846:
1807:
1764:
960:
802:
733:
677:
632:
1584:
777:
553:
2533:
2480:
2090:
1760:
1861:
1834:
1563:
1539:
2815:
2790:
2737:
2712:
2694:
2669:
2552:
2517:
2499:
2464:
2446:
2421:
2220:
2195:
2177:
2152:
1897:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1068:
1063:
1058:
1053:
1048:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
28:
2922:
2912:
2403:
2394:
2378:
2290:
2273:
1986:
1977:
1961:
1597:
1572:
1567:
989:
537:
2377:
Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S (2001).
2336:
2114:
1784:
1600:
795:
574:
2728:
2135:
2031:
1928:
1851:
1811:
561:
2651:
2634:
1717:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1699:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2437:
2272:
Itoh T, Linn S, Kamide R, Tokushige H, Katori N, Hosaka Y, Yamaizumi M (2000).
2168:
878:
2061:
1593:
1543:
694:
591:
541:
2711:
Zheng H, Wang X, Warren AJ, Legerski RJ, Nairn RS, Hamilton JW, Li L (2003).
2211:
2422:"Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions"
2379:"Physical and functional interactions of human DNA polymerase eta with PCNA"
1962:"Physical and functional interactions of human DNA polymerase eta with PCNA"
1179:
938:
816:
761:
748:
660:
647:
549:
2824:
2806:
2781:
2772:
2755:
2754:
Yang IY, Miller H, Wang Z, Frank EG, Ohmori H, Hanaoka F, Moriya M (2003).
2746:
2703:
2685:
2660:
2625:
2596:
2587:
2570:
2561:
2542:
2508:
2489:
2455:
2412:
2369:
2361:
2344:
Matsuda T, Bebenek K, Masutani C, Rogozin IB, Hanaoka F, Kunkel TA (2001).
2328:
2299:
2264:
2255:
2238:
2229:
2186:
2143:
2106:
2069:
2039:
1995:
1946:
1905:
1870:
1819:
1776:
2153:"Mechanisms of accurate translesion synthesis by human DNA polymerase eta"
1505:
1500:
1604:
1489:
1324:
1305:
1525:
1291:
1246:
2617:
1550:, also known as XPV, because loss of this gene results in the disease
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
302:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
1473:
1201:
2345:
516:, RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta
2346:"Error rate and specificity of human and murine DNA polymerase eta"
2320:
2098:
1768:
1164:
1160:
1632:
1547:
1532:
529:
2848:
969:
2844:
1923:. Subcellular Biochemistry. Vol. 50. pp. 189β209.
2014:
Plachta M, Halas, McIntyre J, Sledziewska-Gojska E (2015).
1562:
This gene encodes a member of the Y family of specialized
1615:
Mutations in this gene result in XPV, a variant type of
785:
2463:
Limoli CL, Giedzinski E, Bonner WM, Cleaver JE (2002).
2840:
GeneReviews/NIH/NCBI/UW entry on
Xeroderma Pigmentosum
950:
1430:
1401:
1371:
1342:
2151:Masutani C, Kusumoto R, Iwai S, Hanaoka F (2000).
1734:"Entrez Gene: POLH polymerase (DNA directed), eta"
1673:
1671:
1669:
1652:
1650:
1648:
1575:during immunoglobulin class switch recombination.
2633:Yavuz S, Yavuz AS, Kraemer KH, Lipsky PE (2002).
732:
631:
2194:Yamada A, Masutani C, Iwai S, Hanaoka F (2000).
16:Protein-coding gene in the species Homo sapiens
2237:Yuasa M, Masutani C, Eki T, Hanaoka F (2000).
1678:GRCm38: Ensembl release 89: ENSMUSG00000023953
2860:
8:
1657:GRCh38: Ensembl release 89: ENSG00000170734
2909:United States National Library of Medicine
2867:
2853:
2845:
1546:. The gene encoding DNA polymerase eta is
1175:
985:
831:Skeletal muscle tissue of rectus abdominis
773:
672:
569:
63:
2814:
2771:
2736:
2693:
2650:
2586:
2551:
2541:
2498:
2488:
2445:
2402:
2289:
2254:
2219:
2176:
1985:
1860:
1850:
1833:Rodriguez GP, Song JB, Crouse GF (2013).
2907:This article incorporates text from the
1728:
1726:
1115:cellular response to DNA damage stimulus
2882:
1644:
18:
737:
698:
693:
636:
595:
590:
7:
1085:DNA synthesis involved in DNA repair
1033:DNA-directed DNA polymerase activity
889:endothelial cell of lymphatic vessel
2420:Glick E, Vigna KL, Loeb LA (2001).
1921:Genome Stability and Human Diseases
1544:DNA repair by translesion synthesis
1538:DNA polymerase eta is a eukaryotic
1427:
1398:
1368:
1339:
1315:
1296:
1270:
1251:
1225:
1206:
955:
873:
811:
790:
14:
1528:that in humans is encoded by the
1150:error-prone translesion synthesis
2885:
2395:10.1128/MCB.21.21.7199-7206.2001
2291:10.1046/j.1523-1747.2000.00154.x
1978:10.1128/MCB.21.21.7199-7206.2001
1105:error-free translesion synthesis
959:
721:
714:
708:
685:
620:
613:
607:
582:
27:
1013:nucleotidyltransferase activity
970:More reference expression data
939:More reference expression data
1:
2729:10.1128/MCB.23.2.754-761.2003
1898:10.1016/S0923-2508(02)01343-8
706:
605:
2522:Proc. Natl. Acad. Sci. U.S.A
2469:Proc. Natl. Acad. Sci. U.S.A
2136:10.1126/science.285.5425.263
2032:10.1016/j.dnarep.2015.02.015
1929:10.1007/978-90-481-3471-7_10
1852:10.1371/journal.pgen.1003682
1812:10.1126/science.285.5425.263
2929:Genes on human chromosome 6
2652:10.4049/jimmunol.169.7.3825
1835:"In vivo bypass of 8-oxodG"
1069:site of double-strand break
835:stromal cell of endometrium
2955:
2880:
2062:10.1016/j.jmb.2006.11.093
1713:"Mouse PubMed Reference:"
1695:"Human PubMed Reference:"
1504:
1499:
1495:
1488:
1472:
1453:
1434:
1405:
1394:
1375:
1346:
1335:
1322:
1318:
1303:
1299:
1290:
1277:
1273:
1258:
1254:
1245:
1232:
1228:
1213:
1209:
1200:
1185:
1178:
1174:
1158:
1125:cellular response to UV-C
988:
984:
967:
958:
949:
936:
885:
876:
823:
814:
784:
776:
772:
755:
742:
705:
684:
675:
671:
654:
641:
604:
581:
572:
568:
523:
520:
510:
503:
498:
71:
66:
49:
44:
39:
35:
26:
21:
2438:10.1093/emboj/20.24.7303
2169:10.1093/emboj/19.12.3100
1590:Saccharomyces cerevisiae
1466:Chr 17: 46.48 β 46.51 Mb
1110:regulation of DNA repair
1095:DNA biosynthetic process
1627:POLH has been shown to
1459:Chr 6: 43.58 β 43.62 Mb
1090:pyrimidine dimer repair
2773:10.1074/jbc.M212535200
2588:10.1074/jbc.M112139200
2543:10.1073/pnas.022473899
2490:10.1073/pnas.231611798
2362:10.1006/jmbi.2001.4937
2256:10.1038/sj.onc.1203842
2212:10.1093/nar/28.13.2473
1579:Bypass of 8-oxoguanine
1100:postreplication repair
917:mesenteric lymph nodes
909:lumbar spinal ganglion
1617:xeroderma pigmentosum
1611:Clinical significance
1552:xeroderma pigmentosum
1145:response to radiation
1130:translesion synthesis
700:Chromosome 17 (mouse)
2939:DNA-binding proteins
2807:10.1093/emboj/cdf618
2686:10.1093/emboj/cdf618
1598:oxidative DNA damage
1003:transferase activity
598:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
2534:2002PNAS...99..815B
2481:2002PNAS...99..233L
2278:J. Invest. Dermatol
2091:1999Natur.399..700M
1761:1999Natur.399..700M
1023:damaged DNA binding
847:epithelium of colon
2911:, which is in the
1518:DNA polymerase eta
1280:ENSMUSG00000023953
1078:Biological process
1042:Cellular component
996:Molecular function
859:tail of epididymis
843:lower lobe of lung
827:buccal mucosa cell
2903:
2902:
2618:10.1021/bi025549k
2200:Nucleic Acids Res
1938:978-90-481-3470-0
1515:
1514:
1511:
1510:
1484:
1483:
1449:
1448:
1424:
1423:
1390:
1389:
1365:
1364:
1331:
1330:
1312:
1311:
1286:
1285:
1267:
1266:
1241:
1240:
1222:
1221:
1170:
1169:
1018:metal ion binding
980:
979:
976:
975:
945:
944:
932:
931:
870:
869:
768:
767:
667:
666:
494:
493:
490:
489:
50:Ortholog search:
2946:
2889:
2869:
2862:
2855:
2846:
2828:
2818:
2785:
2775:
2766:(16): 13989β94.
2750:
2740:
2707:
2697:
2664:
2654:
2629:
2600:
2590:
2581:(14): 11765β71.
2565:
2555:
2545:
2512:
2502:
2492:
2459:
2449:
2416:
2406:
2389:(21): 7199β206.
2373:
2340:
2303:
2293:
2268:
2258:
2233:
2223:
2190:
2180:
2147:
2118:
2073:
2043:
2000:
1999:
1989:
1972:(21): 7199β206.
1957:
1951:
1950:
1916:
1910:
1909:
1881:
1875:
1874:
1864:
1854:
1830:
1824:
1823:
1795:
1789:
1788:
1744:
1738:
1737:
1730:
1721:
1720:
1709:
1703:
1702:
1691:
1685:
1675:
1664:
1654:
1542:involved in the
1497:
1496:
1468:
1461:
1444:
1428:
1419:
1399:
1395:RefSeq (protein)
1385:
1369:
1360:
1340:
1316:
1297:
1271:
1252:
1226:
1207:
1176:
1135:response to UV-C
1064:replication fork
986:
972:
963:
956:
941:
925:seminal vesicula
881:
879:Top expressed in
874:
863:ventricular zone
819:
817:Top expressed in
812:
791:
774:
764:
751:
740:
725:
718:
712:
701:
689:
673:
663:
650:
639:
624:
617:
611:
600:
586:
570:
564:
562:POLH - orthologs
515:
508:
485:
64:
58:
37:
36:
31:
19:
2954:
2953:
2949:
2948:
2947:
2945:
2944:
2943:
2934:DNA replication
2919:
2918:
2904:
2899:
2896:
2890:
2876:
2873:
2836:
2831:
2788:
2753:
2717:Mol. Cell. Biol
2710:
2680:(22): 6246β56.
2667:
2632:
2603:
2568:
2515:
2462:
2432:(24): 7303β12.
2419:
2383:Mol. Cell. Biol
2376:
2343:
2306:
2271:
2236:
2206:(13): 2473β80.
2193:
2150:
2130:(5425): 263β5.
2121:
2085:(6737): 700β4.
2076:
2046:
2013:
2009:
2007:Further reading
2004:
2003:
1966:Mol. Cell. Biol
1959:
1958:
1954:
1939:
1918:
1917:
1913:
1883:
1882:
1878:
1845:(8): e1003682.
1832:
1831:
1827:
1806:(5425): 263β5.
1797:
1796:
1792:
1755:(6737): 700β4.
1746:
1745:
1741:
1732:
1731:
1724:
1711:
1710:
1706:
1693:
1692:
1688:
1676:
1667:
1655:
1646:
1641:
1625:
1613:
1585:DNA replication
1581:
1564:DNA polymerases
1560:
1506:View/Edit Mouse
1501:View/Edit Human
1464:
1457:
1454:Location (UCSC)
1440:
1436:
1415:
1411:
1407:
1381:
1377:
1356:
1352:
1348:
1261:ENSG00000170734
1154:
1120:DNA replication
1073:
1037:
1028:protein binding
968:
937:
928:
923:
919:
915:
911:
907:
903:
899:
895:
891:
877:
866:
861:
857:
853:
849:
845:
841:
839:trabecular bone
837:
833:
829:
815:
759:
746:
738:
728:
727:
726:
719:
699:
676:Gene location (
658:
645:
637:
627:
626:
625:
618:
596:
573:Gene location (
524:
511:
504:
73:
51:
17:
12:
11:
5:
2952:
2950:
2942:
2941:
2936:
2931:
2921:
2920:
2901:
2900:
2898:
2897:
2891:
2884:
2881:
2878:
2877:
2874:
2872:
2871:
2864:
2857:
2849:
2843:
2842:
2835:
2834:External links
2832:
2830:
2829:
2801:(5): 1223β33.
2786:
2751:
2708:
2665:
2645:(7): 3825β30.
2630:
2612:(19): 6090β9.
2601:
2566:
2513:
2460:
2417:
2374:
2341:
2304:
2269:
2249:(41): 4721β8.
2234:
2191:
2163:(12): 3100β9.
2148:
2119:
2074:
2056:(4): 1074β86.
2044:
2010:
2008:
2005:
2002:
2001:
1952:
1937:
1911:
1886:Res. Microbiol
1876:
1825:
1790:
1739:
1722:
1704:
1686:
1665:
1643:
1642:
1640:
1637:
1624:
1621:
1612:
1609:
1580:
1577:
1568:thymine dimers
1559:
1556:
1540:DNA polymerase
1513:
1512:
1509:
1508:
1503:
1493:
1492:
1486:
1485:
1482:
1481:
1479:
1477:
1470:
1469:
1462:
1455:
1451:
1450:
1447:
1446:
1432:
1431:
1425:
1422:
1421:
1403:
1402:
1396:
1392:
1391:
1388:
1387:
1373:
1372:
1366:
1363:
1362:
1344:
1343:
1337:
1333:
1332:
1329:
1328:
1320:
1319:
1313:
1310:
1309:
1301:
1300:
1294:
1288:
1287:
1284:
1283:
1275:
1274:
1268:
1265:
1264:
1256:
1255:
1249:
1243:
1242:
1239:
1238:
1230:
1229:
1223:
1220:
1219:
1211:
1210:
1204:
1198:
1197:
1192:
1187:
1183:
1182:
1172:
1171:
1168:
1167:
1156:
1155:
1153:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1081:
1079:
1075:
1074:
1072:
1071:
1066:
1061:
1056:
1051:
1045:
1043:
1039:
1038:
1036:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
999:
997:
993:
992:
982:
981:
978:
977:
974:
973:
965:
964:
953:
947:
946:
943:
942:
934:
933:
930:
929:
927:
926:
922:
918:
914:
910:
906:
902:
898:
894:
890:
886:
883:
882:
871:
868:
867:
865:
864:
860:
856:
852:
848:
844:
840:
836:
832:
828:
824:
821:
820:
808:
807:
799:
788:
782:
781:
778:RNA expression
770:
769:
766:
765:
757:
753:
752:
744:
741:
736:
730:
729:
720:
713:
707:
703:
702:
697:
691:
690:
682:
681:
669:
668:
665:
664:
656:
652:
651:
643:
640:
635:
629:
628:
619:
612:
606:
602:
601:
594:
588:
587:
579:
578:
566:
565:
522:
518:
517:
509:
501:
500:
496:
495:
492:
491:
488:
487:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2951:
2940:
2937:
2935:
2932:
2930:
2927:
2926:
2924:
2917:
2916:
2914:
2913:public domain
2910:
2894:
2888:
2883:
2879:
2870:
2865:
2863:
2858:
2856:
2851:
2850:
2847:
2841:
2838:
2837:
2833:
2826:
2822:
2817:
2812:
2808:
2804:
2800:
2796:
2792:
2787:
2783:
2779:
2774:
2769:
2765:
2761:
2760:J. Biol. Chem
2757:
2752:
2748:
2744:
2739:
2734:
2730:
2726:
2723:(2): 754β61.
2722:
2718:
2714:
2709:
2705:
2701:
2696:
2691:
2687:
2683:
2679:
2675:
2671:
2666:
2662:
2658:
2653:
2648:
2644:
2640:
2636:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2602:
2598:
2594:
2589:
2584:
2580:
2576:
2575:J. Biol. Chem
2572:
2567:
2563:
2559:
2554:
2549:
2544:
2539:
2535:
2531:
2528:(2): 815β20.
2527:
2523:
2519:
2514:
2510:
2506:
2501:
2496:
2491:
2486:
2482:
2478:
2474:
2470:
2466:
2461:
2457:
2453:
2448:
2443:
2439:
2435:
2431:
2427:
2423:
2418:
2414:
2410:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2375:
2371:
2367:
2363:
2359:
2356:(2): 335β46.
2355:
2351:
2347:
2342:
2338:
2334:
2330:
2326:
2322:
2321:10.1038/88740
2318:
2315:(6): 537β41.
2314:
2310:
2305:
2301:
2297:
2292:
2287:
2283:
2279:
2275:
2270:
2266:
2262:
2257:
2252:
2248:
2244:
2240:
2235:
2231:
2227:
2222:
2217:
2213:
2209:
2205:
2201:
2197:
2192:
2188:
2184:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2099:10.1038/21447
2096:
2092:
2088:
2084:
2080:
2075:
2071:
2067:
2063:
2059:
2055:
2051:
2045:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2012:
2011:
2006:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1953:
1948:
1944:
1940:
1934:
1930:
1926:
1922:
1915:
1912:
1907:
1903:
1899:
1895:
1891:
1887:
1880:
1877:
1872:
1868:
1863:
1858:
1853:
1848:
1844:
1840:
1836:
1829:
1826:
1821:
1817:
1813:
1809:
1805:
1801:
1794:
1791:
1786:
1782:
1778:
1774:
1770:
1769:10.1038/21447
1766:
1762:
1758:
1754:
1750:
1743:
1740:
1735:
1729:
1727:
1723:
1718:
1714:
1708:
1705:
1700:
1696:
1690:
1687:
1683:
1679:
1674:
1672:
1670:
1666:
1662:
1658:
1653:
1651:
1649:
1645:
1638:
1636:
1634:
1630:
1622:
1620:
1618:
1610:
1608:
1606:
1602:
1599:
1595:
1592:
1591:
1586:
1578:
1576:
1574:
1573:hypermutation
1569:
1565:
1557:
1555:
1553:
1549:
1545:
1541:
1536:
1534:
1531:
1527:
1523:
1519:
1507:
1502:
1498:
1494:
1491:
1487:
1480:
1478:
1475:
1471:
1467:
1463:
1460:
1456:
1452:
1445:
1443:
1439:
1433:
1429:
1426:
1420:
1418:
1414:
1410:
1404:
1400:
1397:
1393:
1386:
1384:
1380:
1374:
1370:
1367:
1361:
1359:
1355:
1351:
1345:
1341:
1338:
1336:RefSeq (mRNA)
1334:
1327:
1326:
1321:
1317:
1314:
1308:
1307:
1302:
1298:
1295:
1293:
1289:
1282:
1281:
1276:
1272:
1269:
1263:
1262:
1257:
1253:
1250:
1248:
1244:
1237:
1236:
1231:
1227:
1224:
1218:
1217:
1212:
1208:
1205:
1203:
1199:
1196:
1193:
1191:
1188:
1184:
1181:
1177:
1173:
1166:
1162:
1157:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1082:
1080:
1077:
1076:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1046:
1044:
1041:
1040:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
1000:
998:
995:
994:
991:
990:Gene ontology
987:
983:
971:
966:
962:
957:
954:
952:
948:
940:
935:
924:
920:
916:
912:
908:
905:body of femur
904:
900:
896:
892:
888:
887:
884:
880:
875:
872:
862:
858:
854:
850:
846:
842:
838:
834:
830:
826:
825:
822:
818:
813:
810:
809:
806:
804:
800:
798:
797:
793:
792:
789:
787:
783:
779:
775:
771:
763:
758:
754:
750:
745:
735:
731:
724:
717:
711:
704:
696:
692:
688:
683:
679:
674:
670:
662:
657:
653:
649:
644:
634:
630:
623:
616:
610:
603:
599:
593:
589:
585:
580:
576:
571:
567:
563:
559:
555:
551:
547:
543:
539:
535:
531:
527:
519:
514:
507:
502:
497:
486:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2906:
2905:
2892:
2798:
2794:
2763:
2759:
2720:
2716:
2677:
2673:
2642:
2638:
2609:
2606:Biochemistry
2605:
2578:
2574:
2525:
2521:
2475:(1): 233β8.
2472:
2468:
2429:
2425:
2386:
2382:
2353:
2350:J. Mol. Biol
2349:
2312:
2309:Nat. Immunol
2308:
2284:(6): 981β5.
2281:
2277:
2246:
2242:
2203:
2199:
2160:
2156:
2127:
2123:
2082:
2078:
2053:
2050:J. Mol. Biol
2049:
2023:
2019:
1969:
1965:
1955:
1920:
1914:
1892:(7): 441β5.
1889:
1885:
1879:
1842:
1838:
1828:
1803:
1799:
1793:
1752:
1748:
1742:
1716:
1707:
1698:
1689:
1626:
1623:Interactions
1614:
1601:8-oxoguanine
1588:
1582:
1561:
1537:
1529:
1521:
1517:
1516:
1442:NP_001351876
1435:
1413:NP_001278899
1409:NP_001278898
1406:
1383:NM_001364947
1376:
1354:NM_001291970
1350:NM_001291969
1347:
1323:
1304:
1278:
1259:
1233:
1214:
1194:
1189:
901:cumulus cell
893:spermatocyte
801:
794:
739:17|17 C
521:External IDs
72:
2875:PDB gallery
2026:: 147β153.
1049:nucleoplasm
1008:DNA binding
921:human fetus
897:Paneth cell
760:46,513,571
747:46,482,281
659:43,620,523
646:43,576,185
499:Identifiers
2923:Categories
2639:J. Immunol
2020:DNA Repair
1839:PLOS Genet
1684:, May 2017
1663:, May 2017
1639:References
1594:chromosome
1140:DNA repair
805:(ortholog)
542:HomoloGene
1438:NP_109640
1417:NP_006493
1379:NM_030715
1358:NM_006502
1180:Orthologs
550:GeneCards
2825:12606586
2782:12584190
2747:12509472
2704:12426396
2661:12244178
2626:11994004
2597:11821420
2562:11773631
2509:11756691
2456:11743006
2413:11585903
2370:11554790
2329:11376341
2300:11121129
2265:11032022
2243:Oncogene
2230:10871396
2187:10856253
2144:10398605
2107:10385124
2070:17198712
2040:25766643
1996:11585903
1947:20012583
1906:12405351
1871:23935538
1820:10398605
1777:10385124
1680:–
1659:–
1629:interact
1605:cytosine
1558:Function
1524:), is a
1490:Wikidata
1159:Sources:
2530:Bibcode
2477:Bibcode
2337:6213513
2124:Science
2115:4429698
2087:Bibcode
1862:3731214
1800:Science
1785:4429698
1757:Bibcode
1682:Ensembl
1661:Ensembl
1587:of the
1583:During
1526:protein
1292:UniProt
1247:Ensembl
1186:Species
1165:QuickGO
1059:cytosol
1054:nucleus
780:pattern
538:1891457
506:Aliases
2823:
2816:150329
2813:
2795:EMBO J
2780:
2745:
2738:151552
2735:
2702:
2695:137208
2692:
2674:EMBO J
2659:
2624:
2595:
2560:
2553:117388
2550:
2507:
2500:117544
2497:
2454:
2447:125802
2444:
2426:EMBO J
2411:
2401:
2368:
2335:
2327:
2298:
2263:
2228:
2221:102698
2218:
2185:
2178:203367
2175:
2157:EMBO J
2142:
2113:
2105:
2079:Nature
2068:
2038:
1994:
1984:
1945:
1935:
1904:
1869:
1859:
1818:
1783:
1775:
1749:Nature
1596:, the
1476:search
1474:PubMed
1325:Q9JJN0
1306:Q9Y253
1202:Entrez
951:BioGPS
855:tonsil
851:nipple
638:6p21.1
530:603968
2404:99895
2333:S2CID
2111:S2CID
1987:99895
1781:S2CID
1631:with
1522:Pol Ξ·
1235:80905
1195:Mouse
1190:Human
1161:Amigo
913:fossa
803:Mouse
796:Human
743:Start
678:Mouse
642:Start
575:Human
546:38189
2893:2i5o
2821:PMID
2778:PMID
2743:PMID
2700:PMID
2657:PMID
2622:PMID
2593:PMID
2558:PMID
2505:PMID
2452:PMID
2409:PMID
2366:PMID
2325:PMID
2296:PMID
2261:PMID
2226:PMID
2183:PMID
2140:PMID
2103:PMID
2066:PMID
2036:PMID
1992:PMID
1943:PMID
1933:ISBN
1902:PMID
1867:PMID
1816:PMID
1773:PMID
1633:PCNA
1548:POLH
1533:gene
1530:POLH
1216:5429
786:Bgee
734:Band
695:Chr.
633:Band
592:Chr.
554:POLH
526:OMIM
513:POLH
483:5KFY
479:5KFL
475:5KFS
471:5KG5
467:5L9X
463:5DG9
459:5KFJ
455:5KFF
451:5DG7
447:5KFB
443:5DGA
439:5KFW
435:5KFM
431:5KG3
427:5KFP
423:5KFR
419:5KG2
415:5KFG
411:5KFD
407:5KFE
403:5KFO
399:5KFQ
395:5KG4
391:5KFI
387:5KFK
383:5KFA
379:5KFU
375:5KFC
371:5KFX
367:5KG1
363:5KFZ
359:5KFN
355:5KG0
351:5KG7
347:5KFH
343:5KFV
339:5DG8
335:5KFT
331:5DGB
327:5KG6
323:4Q8E
319:4ED2
315:5EWG
311:4RU9
307:4O3R
303:4DL4
299:4J9L
295:4ED1
291:4O3Q
287:4YR3
283:4ED0
279:4J9R
275:4DL7
271:4ED6
267:3TQ1
263:3MR2
259:4J9Q
255:4J9M
251:3JAA
247:4J9S
243:4ED8
239:4EEY
235:4YR2
231:4ED7
227:5EWF
223:3WUP
219:4ECW
215:4DL2
211:4ECZ
207:4ED3
203:4Q8F
199:4J9P
195:4ECV
191:4O3S
187:4O3O
183:4ECQ
179:4RNO
175:4O3P
171:4ECY
167:3MR3
163:4RNN
159:3MR6
155:4DL6
151:4ECU
147:5EWE
143:4O3N
139:4YP3
135:3SI8
131:4J9N
127:3MR5
123:4J9K
119:4DL3
115:4ECR
111:4DL5
107:2LSK
103:4ECT
99:4ECS
95:4ECX
91:4YR0
87:4YQW
83:4J9O
79:4RNM
75:2I5O
56:RCSB
53:PDBe
22:POLH
2811:PMC
2803:doi
2768:doi
2764:278
2733:PMC
2725:doi
2690:PMC
2682:doi
2647:doi
2643:169
2614:doi
2583:doi
2579:277
2548:PMC
2538:doi
2495:PMC
2485:doi
2442:PMC
2434:doi
2399:PMC
2391:doi
2358:doi
2354:312
2317:doi
2286:doi
2282:115
2251:doi
2216:PMC
2208:doi
2173:PMC
2165:doi
2132:doi
2128:285
2095:doi
2083:399
2058:doi
2054:366
2028:doi
1982:PMC
1974:doi
1925:doi
1894:doi
1890:153
1857:PMC
1847:doi
1808:doi
1804:285
1765:doi
1753:399
756:End
655:End
558:OMA
534:MGI
46:PDB
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