498:
475:
372:
397:
2335:
2410:
2350:
2440:
2305:
2320:
2425:
2395:
2380:
2365:
749:
2290:
2500:
2470:
2485:
504:
403:
2455:
29:
1407:. The 8 kDa domain has lyase activity that can remove a 5' deoxyribosephosphate group from the end of a strand break. The BRCT domain is a phosphopeptide binding domain that is common among DNA repair proteins and is likely involved in coordinating protein-protein interactions. Pol λ is structurally and functionally related to
55:
1439:
Translesion synthesis is a damage tolerance mechanism in which specialized DNA polymerases substitute for replicative polymerases in copying across DNA damages during replication. DNA polymerase lambda appears to be involved in translesion synthesis of abasic sites and
1381:, pol λ makes extensive contacts with the 5' phosphate of the downstream DNA strand. This allows the polymerase to stabilize the two ends of a double-strand break and explains how pol λ is uniquely suited for a role in non-homologous end joining.
2334:
2409:
2349:
2439:
2304:
2319:
2424:
1995:
Nick McElhinny SA, Ramsden DA (August 2004). "Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repair".
511:
410:
2394:
2379:
2364:
2289:
2499:
997:
978:
333:
2081:"Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo"
2212:"Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis"
1895:"Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair"
2528:
2469:
2269:
1537:
1519:
2484:
1803:
Tano K, Nakamura J, Asagoshi K, Arakawa H, Sonoda E, Braithwaite EK, Prasad R, Buerstedde JM, Takeda S, Watanabe M, Wilson SH (June 2007).
1430:. Whereas pol μ is important for heavy-chain rearrangements, pol λ seems to be more important for light-chain rearrangements. The yeast
497:
52:
1261:
2454:
1268:
474:
1569:
Aoufouchi S, Flatter E, Dahan A, Faili A, Bertocci B, Storck S, Delbos F, Cocea L, Gupta N, Weill JC, Reynaud CA (September 2000).
1555:
1661:"Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts"
1370:. During NHEJ, duplexes generated by the alignment of broken DNA ends usually contain small gaps that need to be filled in by a
1367:
1506:
1485:
396:
371:
1502:
2538:
1481:
313:
2210:
Maga G, Villani G, Ramadan K, Shevelev I, Tanguy Le Gac N, Blanco L, Blanca G, Spadari S, Hübscher U (December 2002).
1453:
1366:. NHEJ is the main pathway in higher eukaryotes for repair of DNA DSBs. Chromosomal DSBs are the most severe type of
510:
409:
1854:"DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts"
1441:
1412:
1359:
2262:
503:
402:
1432:
1042:
321:
1023:
1944:
Yu X, Chini CC, He M, Mer G, Chen J (October 2003). "The BRCT domain is a phospho-protein binding domain".
1805:"Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells"
2040:"Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu"
1764:"A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology"
385:
2343:: Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP
2255:
1953:
1385:
300:
2533:
2418:: DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp and a T:T mismatch
1389:
1240:
1236:
1222:
1218:
1214:
1210:
1191:
1187:
1183:
1157:
1153:
1124:
1120:
1116:
2020:
1977:
1659:
Lee JW, Blanco L, Zhou T, Garcia-Diaz M, Bebenek K, Kunkel TA, Wang Z, Povirk LF (January 2004).
345:
1244:
1226:
1195:
1149:
1128:
2358:: Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate
2233:
2192:
2143:
2102:
2061:
2012:
1969:
1926:
1875:
1834:
1785:
1744:
1692:
1641:
1600:
1408:
293:
45:
2448:: Crystal Structure of human DNA Polymerase lambda with a G/G mismatch in the primer terminus
2313:: Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule
2223:
2182:
2174:
2133:
2092:
2051:
2004:
1961:
1916:
1906:
1865:
1824:
1816:
1775:
1734:
1726:
1682:
1672:
1631:
1590:
1582:
748:
590:
521:
465:
420:
2328:: Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap
1420:
1416:
1378:
565:
341:
2433:: DNA polymerase lambda in complex with Dttp and a DNA duplex containing an unpaired Dtmp
1957:
2187:
2162:
1829:
1804:
1739:
1714:
1371:
1355:
1351:
2163:"A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG"
2056:
2039:
1780:
1763:
1762:
Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, Pedersen LC (February 2004).
1595:
1570:
912:
907:
902:
897:
892:
887:
882:
877:
872:
856:
851:
835:
825:
820:
815:
810:
805:
800:
795:
790:
28:
2522:
2008:
1620:"DNA joint dependence of pol X family polymerase action in nonhomologous end joining"
1427:
777:
2024:
1981:
1377:
The crystal structure of pol λ shows that, unlike the DNA polymerases that catalyze
325:
583:
362:
2138:
2121:
2097:
2080:
1820:
349:
2403:: DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dcmp
2388:: DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp
2373:: DNA polymerase lambda in complex with a DNA duplex containing an unpaired Dtmp
1542:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1524:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1404:
1397:
1415:. Like pol μ, pol λ participates in V(D)J recombination, the process by which
666:
1424:
1393:
1363:
1332:
482:
379:
329:
1586:
2178:
1965:
1852:
Braithwaite EK, Prasad R, Shock DD, Hou EW, Beard WA, Wilson SH (May 2005).
1392:. BER is the major pathway for repair of small base damages resulting from
942:
726:
604:
549:
536:
448:
435:
337:
2237:
2228:
2211:
2196:
2147:
2106:
2065:
2016:
1973:
1930:
1911:
1894:
1879:
1870:
1853:
1838:
1789:
1748:
1696:
1677:
1660:
1645:
1636:
1619:
1604:
1308:
1303:
1403:
Besides its catalytic polymerase domain, pol λ has an 8 kDa domain and a
1292:
1091:
1087:
1068:
1921:
1687:
2298:: Solution Structure of the Lyase Domain of Human DNA Polymerase Lambda
1054:
1009:
1730:
830:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
230:
226:
222:
218:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
74:
2508:: Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal
1328:
1276:
964:
2161:
Burak MJ, Guja KE, Hambardjieva E, Derkunt B, Garcia-Diaz M (2016).
2038:
Bertocci B, De Smet A, Berek C, Weill JC, Reynaud CA (August 2003).
927:
923:
304:, BETAN, POLKAPPA, polymerase (DNA) lambda, DNA polymerase lambda
1893:
García-Díaz M, Bebenek K, Kunkel TA, Blanco L (September 2001).
1457:
1339:
757:
317:
2251:
2247:
1571:"Two novel human and mouse DNA polymerases of the polX family"
1358:. It is thought to resynthesize missing nucleotides during
1411:, another member of the X family that also participates in
1388:(BER), where it provides backup activity in the absence of
1436:
has a single homolog of both pol λ and pol μ called Pol4.
2079:
Bertocci B, De Smet A, Weill JC, Reynaud CA (July 2006).
908:
double-strand break repair via nonhomologous end joining
573:
898:
double-strand break repair via homologous recombination
2478:: DNA Polymerase lambda in complex with DNA and dUPNPP
1618:
Daley JM, Laan RL, Suresh A, Wilson TE (August 2005).
1556:"Entrez Gene: POLL polymerase (DNA directed), lambda"
738:
2493:: DNA Polymerase lambda in complex with DNA and dCTP
1374:. DNA polymerase lambda can perform this function.
1384:In addition to NHEJ, pol λ can also participate in
1209:
1176:
1142:
1109:
1498:
1496:
1494:
1477:
1475:
1473:
520:
419:
2463:: Na in the active site of DNA Polymerase lambda
1715:"Structure-function studies of DNA polymerase λ"
1396:, oxidation, depurination/depyrimidination, and
16:Protein-coding gene in the species Homo sapiens
1708:
1706:
1503:GRCm38: Ensembl release 89: ENSMUSG00000025218
2263:
883:somatic hypermutation of immunoglobulin genes
8:
1482:GRCh38: Ensembl release 89: ENSG00000166169
2270:
2256:
2248:
1713:Bebenek K, Pedersen LC, Kunkel TA (2014).
1206:
938:
773:
561:
460:
357:
63:
2227:
2186:
2137:
2122:"The polymerases for V(D)J recombination"
2096:
2055:
1920:
1910:
1869:
1828:
1779:
1738:
1686:
1676:
1635:
1594:
826:5'-deoxyribose-5-phosphate lyase activity
888:cellular response to DNA damage stimulus
2285:
1469:
18:
525:
486:
481:
424:
383:
378:
7:
1364:DNA double-strand break (DSB) repair
821:DNA-directed DNA polymerase activity
1335:. In humans, it is encoded by the
1173:
1139:
1106:
1078:
1059:
1033:
1014:
988:
969:
743:
661:
599:
578:
14:
903:base-excision repair, gap-filling
2498:
2483:
2468:
2453:
2438:
2423:
2408:
2393:
2378:
2363:
2348:
2333:
2318:
2303:
2288:
2009:10.1111/j.0105-2896.2004.00160.x
747:
509:
502:
496:
473:
408:
401:
395:
370:
27:
801:nucleotidyltransferase activity
1423:diversity is generated in the
758:More reference expression data
727:More reference expression data
1:
2057:10.1016/S1074-7613(03)00203-6
1781:10.1016/S1097-2765(04)00061-9
494:
393:
2529:Genes on human chromosome 10
2139:10.1016/j.immuni.2006.07.007
2098:10.1016/j.immuni.2006.04.013
1821:10.1016/j.dnarep.2007.01.011
631:right lobe of thyroid gland
2555:
1413:non-homologous end joining
1360:non-homologous end joining
1262:Chr 10: 101.58 – 101.59 Mb
878:nucleotide-excision repair
2283:
1538:"Mouse PubMed Reference:"
1520:"Human PubMed Reference:"
1350:Pol λ is a member of the
1307:
1302:
1298:
1291:
1275:
1256:
1233:
1180:
1169:
1146:
1113:
1102:
1085:
1081:
1066:
1062:
1053:
1040:
1036:
1021:
1017:
1008:
995:
991:
976:
972:
963:
948:
941:
937:
921:
776:
772:
755:
746:
737:
724:
713:medullary collecting duct
673:
664:
611:
602:
572:
564:
560:
543:
530:
493:
472:
463:
459:
442:
429:
392:
369:
360:
356:
311:
308:
298:
291:
286:
71:
66:
49:
44:
39:
35:
26:
21:
1452:Pol λ has been shown to
1433:Saccharomyces cerevisiae
1269:Chr 19: 45.54 – 45.55 Mb
913:DNA biosynthetic process
2179:10.15252/embj.201694332
2120:Lieber MR (July 2006).
1966:10.1126/science.1088753
836:DNA polymerase activity
2229:10.1074/jbc.M206889200
1912:10.1074/jbc.M106336200
1871:10.1074/jbc.M411864200
1678:10.1074/jbc.M307913200
1637:10.1074/jbc.M505277200
1587:10.1093/nar/28.18.3684
1362:(NHEJ), a pathway of
1321:DNA polymerase lambda
488:Chromosome 19 (mouse)
386:Chromosome 10 (human)
2539:DNA-binding proteins
1386:base excision repair
791:transferase activity
67:List of PDB id codes
40:Available structures
1958:2003Sci...302..639Y
685:seminiferous tubule
1809:DNA Repair (Amst.)
1043:ENSMUSG00000025218
866:Biological process
845:Cellular component
784:Molecular function
651:anterior pituitary
615:right uterine tube
2516:
2515:
1731:10.1021/bi4017236
1575:Nucleic Acids Res
1318:
1317:
1314:
1313:
1287:
1286:
1252:
1251:
1203:
1202:
1165:
1164:
1136:
1135:
1098:
1097:
1075:
1074:
1049:
1048:
1030:
1029:
1004:
1003:
985:
984:
933:
932:
811:metal ion binding
768:
767:
764:
763:
733:
732:
720:
719:
658:
657:
556:
555:
455:
454:
282:
281:
278:
277:
50:Ortholog search:
2546:
2502:
2487:
2472:
2457:
2442:
2427:
2412:
2397:
2382:
2367:
2352:
2337:
2322:
2307:
2292:
2272:
2265:
2258:
2249:
2242:
2241:
2231:
2222:(50): 48434–40.
2207:
2201:
2200:
2190:
2158:
2152:
2151:
2141:
2117:
2111:
2110:
2100:
2076:
2070:
2069:
2059:
2035:
2029:
2028:
1992:
1986:
1985:
1952:(5645): 639–42.
1941:
1935:
1934:
1924:
1914:
1905:(37): 34659–63.
1890:
1884:
1883:
1873:
1864:(18): 18469–75.
1849:
1843:
1842:
1832:
1800:
1794:
1793:
1783:
1759:
1753:
1752:
1742:
1710:
1701:
1700:
1690:
1680:
1656:
1650:
1649:
1639:
1615:
1609:
1608:
1598:
1566:
1560:
1559:
1552:
1546:
1545:
1534:
1528:
1527:
1516:
1510:
1500:
1489:
1479:
1323:, also known as
1300:
1299:
1271:
1264:
1247:
1207:
1198:
1174:
1170:RefSeq (protein)
1160:
1140:
1131:
1107:
1079:
1060:
1034:
1015:
989:
970:
939:
774:
760:
751:
744:
729:
709:ventricular zone
693:secondary oocyte
669:
667:Top expressed in
662:
619:body of pancreas
607:
605:Top expressed in
600:
579:
562:
552:
539:
528:
513:
506:
500:
489:
477:
461:
451:
438:
427:
412:
405:
399:
388:
374:
358:
352:
350:POLL - orthologs
303:
296:
273:
64:
58:
37:
36:
31:
19:
2554:
2553:
2549:
2548:
2547:
2545:
2544:
2543:
2519:
2518:
2517:
2512:
2509:
2503:
2494:
2488:
2479:
2473:
2464:
2458:
2449:
2443:
2434:
2428:
2419:
2413:
2404:
2398:
2389:
2383:
2374:
2368:
2359:
2353:
2344:
2338:
2329:
2323:
2314:
2308:
2299:
2293:
2279:
2276:
2246:
2245:
2209:
2208:
2204:
2173:(18): 2045–59.
2160:
2159:
2155:
2119:
2118:
2114:
2078:
2077:
2073:
2037:
2036:
2032:
1994:
1993:
1989:
1943:
1942:
1938:
1892:
1891:
1887:
1851:
1850:
1846:
1802:
1801:
1797:
1761:
1760:
1756:
1725:(17): 2781–92.
1712:
1711:
1704:
1658:
1657:
1653:
1630:(32): 29030–7.
1617:
1616:
1612:
1581:(18): 3684–93.
1568:
1567:
1563:
1554:
1553:
1549:
1536:
1535:
1531:
1518:
1517:
1513:
1501:
1492:
1480:
1471:
1466:
1450:
1421:T-cell receptor
1379:DNA replication
1356:DNA polymerases
1348:
1309:View/Edit Mouse
1304:View/Edit Human
1267:
1260:
1257:Location (UCSC)
1243:
1239:
1235:
1229:
1225:
1221:
1217:
1213:
1194:
1190:
1186:
1182:
1156:
1152:
1148:
1127:
1123:
1119:
1115:
1090:
1024:ENSG00000166169
917:
873:DNA replication
861:
840:
806:protein binding
756:
725:
716:
711:
707:
703:
699:
695:
691:
689:muscle of thigh
687:
683:
679:
665:
654:
649:
645:
641:
639:body of stomach
637:
633:
629:
625:
621:
617:
603:
547:
534:
526:
516:
515:
514:
507:
487:
464:Gene location (
446:
433:
425:
415:
414:
413:
406:
384:
361:Gene location (
312:
299:
292:
73:
51:
17:
12:
11:
5:
2552:
2550:
2542:
2541:
2536:
2531:
2521:
2520:
2514:
2513:
2511:
2510:
2504:
2497:
2495:
2489:
2482:
2480:
2474:
2467:
2465:
2459:
2452:
2450:
2444:
2437:
2435:
2429:
2422:
2420:
2414:
2407:
2405:
2399:
2392:
2390:
2384:
2377:
2375:
2369:
2362:
2360:
2354:
2347:
2345:
2339:
2332:
2330:
2324:
2317:
2315:
2309:
2302:
2300:
2294:
2287:
2284:
2281:
2280:
2277:
2275:
2274:
2267:
2260:
2252:
2244:
2243:
2202:
2153:
2112:
2071:
2030:
1987:
1936:
1885:
1844:
1795:
1754:
1702:
1651:
1610:
1561:
1547:
1529:
1511:
1490:
1468:
1467:
1465:
1462:
1449:
1446:
1372:DNA polymerase
1347:
1344:
1316:
1315:
1312:
1311:
1306:
1296:
1295:
1289:
1288:
1285:
1284:
1282:
1280:
1273:
1272:
1265:
1258:
1254:
1253:
1250:
1249:
1231:
1230:
1204:
1201:
1200:
1178:
1177:
1171:
1167:
1166:
1163:
1162:
1144:
1143:
1137:
1134:
1133:
1111:
1110:
1104:
1100:
1099:
1096:
1095:
1083:
1082:
1076:
1073:
1072:
1064:
1063:
1057:
1051:
1050:
1047:
1046:
1038:
1037:
1031:
1028:
1027:
1019:
1018:
1012:
1006:
1005:
1002:
1001:
993:
992:
986:
983:
982:
974:
973:
967:
961:
960:
955:
950:
946:
945:
935:
934:
931:
930:
919:
918:
916:
915:
910:
905:
900:
895:
890:
885:
880:
875:
869:
867:
863:
862:
860:
859:
854:
848:
846:
842:
841:
839:
838:
833:
831:DNA polymerase
828:
823:
818:
816:lyase activity
813:
808:
803:
798:
793:
787:
785:
781:
780:
770:
769:
766:
765:
762:
761:
753:
752:
741:
735:
734:
731:
730:
722:
721:
718:
717:
715:
714:
710:
706:
702:
698:
697:primary oocyte
694:
690:
686:
682:
678:
674:
671:
670:
659:
656:
655:
653:
652:
648:
644:
640:
636:
632:
628:
624:
620:
616:
612:
609:
608:
596:
595:
587:
576:
570:
569:
566:RNA expression
558:
557:
554:
553:
545:
541:
540:
532:
529:
524:
518:
517:
508:
501:
495:
491:
490:
485:
479:
478:
470:
469:
457:
456:
453:
452:
444:
440:
439:
431:
428:
423:
417:
416:
407:
400:
394:
390:
389:
382:
376:
375:
367:
366:
354:
353:
310:
306:
305:
297:
289:
288:
284:
283:
280:
279:
276:
275:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2551:
2540:
2537:
2535:
2532:
2530:
2527:
2526:
2524:
2507:
2501:
2496:
2492:
2486:
2481:
2477:
2471:
2466:
2462:
2456:
2451:
2447:
2441:
2436:
2432:
2426:
2421:
2417:
2411:
2406:
2402:
2396:
2391:
2387:
2381:
2376:
2372:
2366:
2361:
2357:
2351:
2346:
2342:
2336:
2331:
2327:
2321:
2316:
2312:
2306:
2301:
2297:
2291:
2286:
2282:
2273:
2268:
2266:
2261:
2259:
2254:
2253:
2250:
2239:
2235:
2230:
2225:
2221:
2217:
2216:J. Biol. Chem
2213:
2206:
2203:
2198:
2194:
2189:
2184:
2180:
2176:
2172:
2168:
2164:
2157:
2154:
2149:
2145:
2140:
2135:
2131:
2127:
2123:
2116:
2113:
2108:
2104:
2099:
2094:
2090:
2086:
2082:
2075:
2072:
2067:
2063:
2058:
2053:
2050:(2): 203–11.
2049:
2045:
2041:
2034:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
2002:
1998:
1991:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1947:
1940:
1937:
1932:
1928:
1923:
1918:
1913:
1908:
1904:
1900:
1899:J. Biol. Chem
1896:
1889:
1886:
1881:
1877:
1872:
1867:
1863:
1859:
1858:J. Biol. Chem
1855:
1848:
1845:
1840:
1836:
1831:
1826:
1822:
1818:
1815:(6): 869–75.
1814:
1810:
1806:
1799:
1796:
1791:
1787:
1782:
1777:
1774:(4): 561–72.
1773:
1769:
1765:
1758:
1755:
1750:
1746:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1707:
1703:
1698:
1694:
1689:
1684:
1679:
1674:
1671:(1): 805–11.
1670:
1666:
1665:J. Biol. Chem
1662:
1655:
1652:
1647:
1643:
1638:
1633:
1629:
1625:
1624:J. Biol. Chem
1621:
1614:
1611:
1606:
1602:
1597:
1592:
1588:
1584:
1580:
1576:
1572:
1565:
1562:
1557:
1551:
1548:
1543:
1539:
1533:
1530:
1525:
1521:
1515:
1512:
1508:
1504:
1499:
1497:
1495:
1491:
1487:
1483:
1478:
1476:
1474:
1470:
1463:
1461:
1459:
1455:
1447:
1445:
1443:
1437:
1435:
1434:
1429:
1428:immune system
1426:
1422:
1418:
1414:
1410:
1406:
1401:
1399:
1395:
1391:
1387:
1382:
1380:
1375:
1373:
1369:
1365:
1361:
1357:
1353:
1345:
1343:
1341:
1338:
1334:
1331:found in all
1330:
1326:
1322:
1310:
1305:
1301:
1297:
1294:
1290:
1283:
1281:
1278:
1274:
1270:
1266:
1263:
1259:
1255:
1248:
1246:
1242:
1238:
1232:
1228:
1224:
1220:
1216:
1212:
1208:
1205:
1199:
1197:
1193:
1189:
1185:
1179:
1175:
1172:
1168:
1161:
1159:
1155:
1151:
1145:
1141:
1138:
1132:
1130:
1126:
1122:
1118:
1112:
1108:
1105:
1103:RefSeq (mRNA)
1101:
1094:
1093:
1089:
1084:
1080:
1077:
1071:
1070:
1065:
1061:
1058:
1056:
1052:
1045:
1044:
1039:
1035:
1032:
1026:
1025:
1020:
1016:
1013:
1011:
1007:
1000:
999:
994:
990:
987:
981:
980:
975:
971:
968:
966:
962:
959:
956:
954:
951:
947:
944:
940:
936:
929:
925:
920:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
870:
868:
865:
864:
858:
855:
853:
850:
849:
847:
844:
843:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
788:
786:
783:
782:
779:
778:Gene ontology
775:
771:
759:
754:
750:
745:
742:
740:
736:
728:
723:
712:
708:
704:
700:
696:
692:
688:
684:
680:
676:
675:
672:
668:
663:
660:
650:
647:apex of heart
646:
642:
638:
634:
630:
626:
622:
618:
614:
613:
610:
606:
601:
598:
597:
594:
592:
588:
586:
585:
581:
580:
577:
575:
571:
567:
563:
559:
551:
546:
542:
538:
533:
527:19|19 C3
523:
519:
512:
505:
499:
492:
484:
480:
476:
471:
467:
462:
458:
450:
445:
441:
437:
432:
422:
418:
411:
404:
398:
391:
387:
381:
377:
373:
368:
364:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
307:
302:
295:
290:
285:
274:
272:
268:
264:
260:
256:
252:
248:
244:
240:
236:
232:
228:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2505:
2490:
2475:
2460:
2445:
2430:
2415:
2400:
2385:
2370:
2355:
2340:
2325:
2310:
2295:
2219:
2215:
2205:
2170:
2166:
2156:
2129:
2125:
2115:
2091:(1): 31–41.
2088:
2084:
2074:
2047:
2043:
2033:
2000:
1997:Immunol. Rev
1996:
1990:
1949:
1945:
1939:
1922:10261/338865
1902:
1898:
1888:
1861:
1857:
1847:
1812:
1808:
1798:
1771:
1767:
1757:
1722:
1719:Biochemistry
1718:
1688:10261/338875
1668:
1664:
1654:
1627:
1623:
1613:
1578:
1574:
1564:
1550:
1541:
1532:
1523:
1514:
1451:
1448:Interactions
1438:
1431:
1402:
1383:
1376:
1349:
1336:
1324:
1320:
1319:
1241:NP_001317436
1237:NP_001317435
1234:
1223:NP_001334535
1219:NP_001334533
1215:NP_001334532
1211:NP_001334531
1192:NP_001295311
1188:NP_001167556
1184:NP_001167555
1181:
1158:NM_001330507
1154:NM_001330506
1147:
1125:NM_001308382
1121:NM_001174085
1117:NM_001174084
1114:
1086:
1067:
1041:
1022:
996:
977:
957:
952:
677:spermatocyte
627:right testis
589:
582:
447:101,588,270
434:101,578,882
309:External IDs
72:
2278:PDB gallery
1405:BRCT domain
1398:deamination
857:nucleoplasm
796:DNA binding
701:granulocyte
643:granulocyte
623:left testis
548:45,548,970
535:45,540,714
287:Identifiers
2534:DNA repair
2523:Categories
2132:(1): 7–9.
2003:: 156–64.
1509:, May 2017
1488:, May 2017
1464:References
1425:vertebrate
1394:alkylation
1368:DNA damage
1333:eukaryotes
893:DNA repair
593:(ortholog)
330:HomoloGene
1768:Mol. Cell
1444:damages.
1245:NP_064416
1227:NP_036178
1196:NP_037406
1150:NM_020032
1129:NM_013274
943:Orthologs
681:spermatid
338:GeneCards
2238:12368291
2197:27481934
2148:16860749
2126:Immunity
2107:16860755
2085:Immunity
2066:12932354
2044:Immunity
2025:36516952
2017:15242403
1982:29407635
1974:14576433
1931:11457865
1880:15749700
1839:17363341
1790:14992725
1749:24716527
1697:14561766
1646:15964833
1605:10982892
1505:–
1484:–
1454:interact
1400:of DNA.
1352:X family
1346:Function
1327:, is an
1293:Wikidata
922:Sources:
426:10q24.32
2188:5282837
1954:Bibcode
1946:Science
1830:2080795
1740:4018081
1507:Ensembl
1486:Ensembl
1442:8-oxodG
1055:UniProt
1010:Ensembl
949:Species
928:QuickGO
852:nucleus
568:pattern
326:1889000
294:Aliases
2236:
2195:
2185:
2167:EMBO J
2146:
2105:
2064:
2023:
2015:
1980:
1972:
1929:
1878:
1837:
1827:
1788:
1747:
1737:
1695:
1644:
1603:
1596:110747
1593:
1417:B-cell
1329:enzyme
1279:search
1277:PubMed
1092:Q9QXE2
1088:Q9QUG2
1069:Q9UGP5
965:Entrez
739:BioGPS
705:zygote
318:606343
2021:S2CID
1978:S2CID
1456:with
1409:pol μ
1390:Pol β
1325:Pol λ
998:56626
979:27343
958:Mouse
953:Human
924:Amigo
635:blood
591:Mouse
584:Human
531:Start
466:Mouse
430:Start
363:Human
334:40863
2506:2pfq
2491:2pfp
2476:2pfo
2461:2pfn
2446:2gws
2431:2bcv
2416:2bcu
2401:2bcs
2386:2bcr
2371:2bcq
2356:1xsp
2341:1xsn
2326:1xsl
2311:1rzt
2296:1nzp
2234:PMID
2193:PMID
2144:PMID
2103:PMID
2062:PMID
2013:PMID
1970:PMID
1927:PMID
1876:PMID
1835:PMID
1786:PMID
1745:PMID
1693:PMID
1642:PMID
1601:PMID
1458:PCNA
1419:and
1340:gene
1337:POLL
574:Bgee
522:Band
483:Chr.
421:Band
380:Chr.
342:POLL
314:OMIM
301:POLL
271:5CA7
267:5CHG
263:4XRH
259:5CWR
255:5CB1
251:5DDM
247:5DDY
243:5CP2
239:5DKW
235:5CJ7
231:4XQ8
227:5CR0
223:4X5V
219:4XUS
215:4XA5
211:4K4I
207:4K4H
203:4K4G
199:4FO6
195:3UQ2
191:3UQ0
187:3UPQ
183:3PNC
179:3PMN
175:3PML
171:3MGI
167:3MGH
163:3MDC
159:3MDA
155:3HX0
151:3HWT
147:3HW8
143:3C5G
139:3C5F
135:2PFQ
131:2PFP
127:2PFO
123:2PFN
119:2JW5
115:2GWS
111:2BCV
107:2BCU
103:2BCS
99:2BCR
95:2BCQ
91:1XSP
87:1XSN
83:1XSL
79:1RZT
75:1NZP
56:RCSB
53:PDBe
22:POLL
2224:doi
2220:277
2183:PMC
2175:doi
2134:doi
2093:doi
2052:doi
2005:doi
2001:200
1962:doi
1950:302
1917:hdl
1907:doi
1903:276
1866:doi
1862:280
1825:PMC
1817:doi
1776:doi
1735:PMC
1727:doi
1683:hdl
1673:doi
1669:279
1632:doi
1628:280
1591:PMC
1583:doi
1354:of
544:End
443:End
346:OMA
322:MGI
46:PDB
2525::
2232:.
2218:.
2214:.
2191:.
2181:.
2171:35
2169:.
2165:.
2142:.
2130:25
2128:.
2124:.
2101:.
2089:25
2087:.
2083:.
2060:.
2048:19
2046:.
2042:.
2019:.
2011:.
1999:.
1976:.
1968:.
1960:.
1948:.
1925:.
1915:.
1901:.
1897:.
1874:.
1860:.
1856:.
1833:.
1823:.
1811:.
1807:.
1784:.
1772:13
1770:.
1766:.
1743:.
1733:.
1723:53
1721:.
1717:.
1705:^
1691:.
1681:.
1667:.
1663:.
1640:.
1626:.
1622:.
1599:.
1589:.
1579:28
1577:.
1573:.
1540:.
1522:.
1493:^
1472:^
1460:.
1342:.
926:/
550:bp
537:bp
449:bp
436:bp
344:;
340::
336:;
332::
328:;
324::
320:;
316::
269:,
265:,
261:,
257:,
253:,
249:,
245:,
241:,
237:,
233:,
229:,
225:,
221:,
217:,
213:,
209:,
205:,
201:,
197:,
193:,
189:,
185:,
181:,
177:,
173:,
169:,
165:,
161:,
157:,
153:,
149:,
145:,
141:,
137:,
133:,
129:,
125:,
121:,
117:,
113:,
109:,
105:,
101:,
97:,
93:,
89:,
85:,
81:,
77:,
2271:e
2264:t
2257:v
2240:.
2226::
2199:.
2177::
2150:.
2136::
2109:.
2095::
2068:.
2054::
2027:.
2007::
1984:.
1964::
1956::
1933:.
1919::
1909::
1882:.
1868::
1841:.
1819::
1813:6
1792:.
1778::
1751:.
1729::
1699:.
1685::
1675::
1648:.
1634::
1607:.
1585::
1558:.
1544:.
1526:.
468:)
365:)
348::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
