262:
239:
136:
161:
527:
513:
520:
268:
167:
1700:
1410:
Nishikimi A, Meller N, Uekawa N, et al. (February 2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes".
1550:
Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes".
275:
174:
1147:
Dock10 shares the same domain arrangement as other members of the DOCK-D/Zizimin subfamily as well as a high level of sequence similarity. It contains a
760:
741:
97:
1370:
Yelo E, Bernardo MV, Gimeno L, et al. (July 2008). "Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes".
1769:
1294:
1745:
1276:
1764:
996:
261:
1089:
1510:
Fluge Ø, Bruland O, Akslen LA, et al. (February 2006). "Gene expression in poorly differentiated papillary thyroid carcinomas".
1647:
1003:
238:
1312:
1328:"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity"
1263:
1242:
1186:
although these interactions are of low affinity. The physiological role of Dock10 is poorly characterised, however a study in
1259:
160:
135:
1238:
1199:
77:
33:
1214:
274:
173:
267:
166:
1738:
1109:
805:
85:
786:
1117:
1630:
Côté JF, Vuori K (2006). "In Vitro
Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains".
1731:
1559:
1419:
149:
64:
526:
979:
975:
967:
946:
938:
908:
887:
875:
512:
1583:
1443:
1213:. Another study in 2006 identified Dock10 as a protein that was overexpressed in some aggressive
1210:
109:
971:
942:
912:
883:
879:
1673:
1653:
1643:
1618:
1575:
1527:
1492:
1435:
1387:
1349:
1113:
57:
1715:
1635:
1608:
1567:
1519:
1482:
1474:
1427:
1379:
1339:
519:
354:
285:
229:
184:
105:
1191:
1171:
1093:
1074:
329:
1563:
1423:
1487:
1462:
1085:
1639:
675:
670:
665:
660:
655:
650:
634:
629:
624:
619:
614:
609:
604:
599:
594:
578:
573:
568:
1758:
1682:
1206:
1156:
1105:
1071:
555:
1587:
1447:
89:
1711:
1195:
1183:
1179:
347:
126:
1571:
1431:
1383:
113:
1299:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1281:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1152:
1148:
1463:"Function of the N-terminus of zizimin1: autoinhibition and membrane targeting"
430:
1187:
1160:
246:
143:
93:
1523:
1163:
1120:
705:
490:
368:
313:
300:
212:
199:
101:
1657:
1622:
1579:
1531:
1496:
1439:
1391:
1353:
1043:
1038:
1203:
1027:
850:
831:
1687:
1677:
1478:
1067:
817:
772:
1613:
1596:
1344:
1327:
17:
1209:. This suggests that Dock10 may have a role in B-cell activation and
1136:
1128:
1011:
727:
1699:
1174:. The DHR2 domain of Dock10 appears to bind to the small G proteins
1175:
1167:
1124:
32:"Dock10" redirects here. For the British television facility, see
690:
686:
1707:
1461:
Meller N, Westbrook MJ, Shannon JD, et al. (January 2008).
1132:
1081:
535:
81:
1155:, which, in some DOCK family proteins, interacts with membrane
68:, DRIP2, Nbla10300, ZIZ3, Dock10, dedicator of cytokinesis 10
1672:
Overview of all the structural information available in the
1159:. Like other DOCK-D subfamily proteins Dock10 contains an
1634:. Methods in Enzymology. Vol. 406. pp. 41–57.
337:
1719:
1632:
Regulators and
Effectors of Small GTPases: Rho Family
502:
960:
931:
901:
868:
1255:
1253:
1251:
1234:
1232:
1230:
1112:proteins (the DOCK family) that share significant
1313:"Entrez Gene: DOCK10 dedicator of cytokinesis 10"
284:
183:
1405:
1403:
1401:
1084:. It is a member of the DOCK-D subfamily of the
1260:GRCm38: Ensembl release 89: ENSMUSG00000038608
1739:
1686:(Dedicator of cytokinesis protein 10) at the
8:
1151:that is involved in G protein binding and a
1365:
1363:
1239:GRCh38: Ensembl release 89: ENSG00000135905
1746:
1732:
701:
574:guanyl-nucleotide exchange factor activity
551:
325:
224:
121:
1612:
1486:
1343:
651:small GTPase mediated signal transduction
1597:"CZH proteins: a new family of Rho-GEFs"
1226:
671:positive regulation of GTPase activity
38:
289:
250:
245:
188:
147:
142:
7:
1696:
1694:
666:marginal zone B cell differentiation
1595:Meller N, Merlot S, Guda C (2005).
1090:guanine nucleotide exchange factors
1056:Dedicator of cytokinesis protein 10
1718:. You can help Knowledge (XXG) by
1326:Côté JF, Vuori K (December 2002).
1092:, which function as activators of
957:
928:
898:
865:
841:
822:
796:
777:
751:
732:
635:intracellular anatomical structure
507:
425:
363:
342:
25:
1108:approaches as one of a family of
1077:that in humans is encoded by the
1698:
525:
518:
511:
395:inferior ganglion of vagus nerve
273:
266:
260:
237:
172:
165:
159:
134:
1202:(CLL) cells in response to the
1170:, mediates recruitment to the
536:More reference expression data
491:More reference expression data
1:
1770:Human chromosome 2 gene stubs
1640:10.1016/S0076-6879(06)06004-6
1572:10.1016/j.febslet.2005.01.006
1432:10.1016/j.febslet.2005.01.006
676:dendritic spine morphogenesis
258:
157:
1384:10.1016/j.molimm.2008.04.003
1215:papillary thyroid carcinomas
1200:Chronic Lymphocytic Leukemia
656:regulation of cell migration
34:Dock10 (television facility)
1765:Genes on human chromosome 2
1786:
1693:
1104:Dock10 was identified via
31:
1295:"Mouse PubMed Reference:"
1277:"Human PubMed Reference:"
1116:. Dock10 is expressed in
1042:
1037:
1033:
1026:
1010:
997:Chr 2: 224.77 – 225.04 Mb
991:
964:
935:
924:
905:
872:
861:
848:
844:
829:
825:
816:
803:
799:
784:
780:
771:
758:
754:
739:
735:
726:
711:
704:
700:
684:
554:
550:
533:
510:
501:
488:
437:
428:
375:
366:
336:
328:
324:
307:
294:
257:
236:
227:
223:
206:
193:
156:
133:
124:
120:
75:
72:
62:
55:
50:
46:
41:
1110:evolutionarily conserved
1066:, is a large (~240 kDa)
383:internal globus pallidus
1524:10.1089/thy.2006.16.161
1004:Chr 1: 80.48 – 80.74 Mb
477:suprachiasmatic nucleus
27:Protein found in humans
1190:has shown that Dock10
1143:Structure and function
453:lateral septal nucleus
441:mesenteric lymph nodes
595:extracellular exosome
469:stroma of bone marrow
252:Chromosome 1 (mouse)
150:Chromosome 2 (human)
1564:2005FEBSL.579.1039N
1424:2005FEBSL.579.1039N
1075:signalling networks
415:subthalamic nucleus
1706:This article on a
1607:(Pt 21): 4937–46.
1479:10.1042/BJ20071263
1338:(Pt 24): 4901–13.
1194:is upregulated in
1123:as well as in the
806:ENSMUSG00000038608
661:B cell homeostasis
644:Biological process
588:Cellular component
579:molecular function
562:Molecular function
391:buccal mucosa cell
114:DOCK10 - orthologs
1727:
1726:
1614:10.1242/jcs.02671
1345:10.1242/jcs.00219
1114:sequence homology
1062:), also known as
1053:
1052:
1049:
1048:
1022:
1021:
987:
986:
954:
953:
920:
919:
895:
894:
857:
856:
838:
837:
812:
811:
793:
792:
767:
766:
748:
747:
696:
695:
546:
545:
542:
541:
497:
496:
484:
483:
422:
421:
411:bone marrow cells
320:
319:
219:
218:
16:(Redirected from
1777:
1748:
1741:
1734:
1702:
1695:
1661:
1626:
1616:
1591:
1536:
1535:
1507:
1501:
1500:
1490:
1458:
1452:
1451:
1407:
1396:
1395:
1367:
1358:
1357:
1347:
1323:
1317:
1316:
1309:
1303:
1302:
1291:
1285:
1284:
1273:
1267:
1257:
1246:
1236:
1118:peripheral blood
1094:small G-proteins
1035:
1034:
1006:
999:
982:
958:
949:
929:
925:RefSeq (protein)
915:
899:
890:
866:
842:
823:
797:
778:
752:
733:
702:
552:
538:
529:
522:
515:
508:
493:
473:substantia nigra
433:
431:Top expressed in
426:
407:substantia nigra
371:
369:Top expressed in
364:
343:
326:
316:
303:
292:
277:
270:
264:
253:
241:
225:
215:
202:
191:
176:
169:
163:
152:
138:
122:
116:
67:
60:
39:
21:
1785:
1784:
1780:
1779:
1778:
1776:
1775:
1774:
1755:
1754:
1753:
1752:
1669:
1664:
1650:
1629:
1594:
1549:
1545:
1543:Further reading
1540:
1539:
1509:
1508:
1504:
1460:
1459:
1455:
1409:
1408:
1399:
1378:(12): 3411–18.
1369:
1368:
1361:
1325:
1324:
1320:
1311:
1310:
1306:
1293:
1292:
1288:
1275:
1274:
1270:
1258:
1249:
1237:
1228:
1223:
1172:plasma membrane
1145:
1102:
1044:View/Edit Mouse
1039:View/Edit Human
1002:
995:
992:Location (UCSC)
978:
974:
970:
966:
945:
941:
937:
911:
907:
886:
882:
878:
874:
787:ENSG00000135905
680:
639:
620:dendritic spine
615:cell projection
583:
569:protein binding
534:
524:
523:
517:
516:
489:
480:
475:
471:
467:
463:
461:globus pallidus
459:
455:
451:
447:
443:
429:
418:
413:
409:
405:
401:
397:
393:
389:
385:
381:
379:corpus callosum
367:
311:
298:
290:
280:
279:
278:
271:
251:
228:Gene location (
210:
197:
189:
179:
178:
177:
170:
148:
125:Gene location (
76:
63:
56:
37:
28:
23:
22:
15:
12:
11:
5:
1783:
1781:
1773:
1772:
1767:
1757:
1756:
1751:
1750:
1743:
1736:
1728:
1725:
1724:
1703:
1692:
1691:
1668:
1667:External links
1665:
1663:
1662:
1648:
1627:
1592:
1558:(5): 1039–46.
1546:
1544:
1541:
1538:
1537:
1502:
1453:
1418:(5): 1039–46.
1397:
1359:
1318:
1304:
1286:
1268:
1247:
1225:
1224:
1222:
1219:
1168:Dock9/Zizimin1
1144:
1141:
1101:
1098:
1051:
1050:
1047:
1046:
1041:
1031:
1030:
1024:
1023:
1020:
1019:
1017:
1015:
1008:
1007:
1000:
993:
989:
988:
985:
984:
962:
961:
955:
952:
951:
933:
932:
926:
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902:
896:
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632:
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581:
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558:
548:
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531:
530:
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494:
486:
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396:
392:
388:
384:
380:
376:
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372:
360:
359:
351:
340:
334:
333:
330:RNA expression
322:
321:
318:
317:
309:
305:
304:
296:
293:
288:
282:
281:
272:
265:
259:
255:
254:
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234:
233:
221:
220:
217:
216:
208:
204:
203:
195:
192:
187:
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180:
171:
164:
158:
154:
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146:
140:
139:
131:
130:
118:
117:
74:
70:
69:
61:
53:
52:
48:
47:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1782:
1771:
1768:
1766:
1763:
1762:
1760:
1749:
1744:
1742:
1737:
1735:
1730:
1729:
1723:
1721:
1717:
1713:
1709:
1704:
1701:
1697:
1689:
1685:
1684:
1679:
1675:
1671:
1670:
1666:
1659:
1655:
1651:
1649:9780121828110
1645:
1641:
1637:
1633:
1628:
1624:
1620:
1615:
1610:
1606:
1602:
1598:
1593:
1589:
1585:
1581:
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1548:
1547:
1542:
1533:
1529:
1525:
1521:
1518:(2): 161–75.
1517:
1513:
1506:
1503:
1498:
1494:
1489:
1484:
1480:
1476:
1473:(2): 525–33.
1472:
1468:
1464:
1457:
1454:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1417:
1413:
1406:
1404:
1402:
1398:
1393:
1389:
1385:
1381:
1377:
1373:
1366:
1364:
1360:
1355:
1351:
1346:
1341:
1337:
1333:
1329:
1322:
1319:
1314:
1308:
1305:
1300:
1296:
1290:
1287:
1282:
1278:
1272:
1269:
1265:
1261:
1256:
1254:
1252:
1248:
1244:
1240:
1235:
1233:
1231:
1227:
1220:
1218:
1216:
1212:
1211:proliferation
1208:
1205:
1201:
1197:
1196:B-lymphocytes
1193:
1189:
1185:
1181:
1177:
1173:
1169:
1165:
1162:
1158:
1157:phospholipids
1154:
1150:
1142:
1140:
1138:
1134:
1130:
1126:
1122:
1119:
1115:
1111:
1107:
1106:bioinformatic
1099:
1097:
1095:
1091:
1087:
1083:
1080:
1076:
1073:
1072:intracellular
1069:
1065:
1061:
1057:
1045:
1040:
1036:
1032:
1029:
1025:
1018:
1016:
1013:
1009:
1005:
1001:
998:
994:
990:
983:
981:
977:
973:
969:
963:
959:
956:
950:
948:
944:
940:
934:
930:
927:
923:
916:
914:
910:
904:
900:
897:
891:
889:
885:
881:
877:
871:
867:
864:
862:RefSeq (mRNA)
860:
853:
852:
847:
843:
840:
834:
833:
828:
824:
821:
819:
815:
808:
807:
802:
798:
795:
789:
788:
783:
779:
776:
774:
770:
763:
762:
757:
753:
750:
744:
743:
738:
734:
731:
729:
725:
722:
719:
717:
714:
710:
707:
703:
699:
692:
688:
683:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
648:
646:
643:
642:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
580:
577:
575:
572:
570:
567:
566:
564:
561:
560:
557:
556:Gene ontology
553:
549:
537:
532:
528:
521:
514:
509:
506:
504:
500:
492:
487:
476:
472:
468:
465:sciatic nerve
464:
460:
456:
452:
448:
445:otolith organ
444:
440:
439:
436:
432:
427:
424:
414:
410:
406:
402:
398:
394:
390:
386:
382:
378:
377:
374:
370:
365:
362:
361:
358:
356:
352:
350:
349:
345:
344:
341:
339:
335:
331:
327:
323:
315:
310:
306:
302:
297:
287:
283:
276:
269:
263:
256:
248:
244:
240:
235:
231:
226:
222:
214:
209:
205:
201:
196:
186:
182:
175:
168:
162:
155:
151:
145:
141:
137:
132:
128:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
71:
66:
59:
54:
49:
45:
40:
35:
30:
19:
1720:expanding it
1712:chromosome 2
1705:
1681:
1631:
1604:
1600:
1555:
1551:
1515:
1511:
1505:
1470:
1466:
1456:
1415:
1412:FEBS Letters
1411:
1375:
1372:Mol. Immunol
1371:
1335:
1331:
1321:
1307:
1298:
1289:
1280:
1271:
1166:, which, in
1146:
1103:
1078:
1070:involved in
1063:
1059:
1055:
1054:
980:NP_001393484
976:NP_001393483
968:NP_001272856
965:
947:NP_001350691
939:NP_001277192
936:
909:NM_001285927
906:
888:NM_001363762
876:NM_001290263
873:
849:
830:
804:
785:
759:
740:
720:
715:
353:
346:
211:225,042,468
198:224,765,090
73:External IDs
29:
1601:J. Cell Sci
1332:J. Cell Sci
1188:lymphocytes
1153:DHR1 domain
1149:DHR2 domain
625:nucleoplasm
403:granulocyte
312:80,736,244
299:80,478,790
291:1|1 C5
51:Identifiers
1759:Categories
1467:Biochem. J
1266:, May 2017
1245:, May 2017
1221:References
1192:expression
1161:N-terminal
1121:leukocytes
1088:family of
387:C1 segment
357:(ortholog)
94:HomoloGene
1710:on human
1552:FEBS Lett
1164:PH domain
1100:Discovery
972:NP_780500
943:NP_055504
913:NM_175291
884:NM_017718
880:NM_014689
706:Orthologs
610:cytoplasm
102:GeneCards
1658:16472648
1623:16254241
1588:36721405
1580:15710388
1532:16676402
1497:17935486
1448:36721405
1440:15710388
1392:18499258
1354:12432077
1262:–
1241:–
1204:cytokine
1064:Zizimin3
1028:Wikidata
685:Sources:
600:membrane
1688:PDBe-KB
1678:UniProt
1560:Bibcode
1512:Thyroid
1488:2740492
1420:Bibcode
1264:Ensembl
1243:Ensembl
1068:protein
818:UniProt
773:Ensembl
712:Species
691:QuickGO
630:cytosol
605:nucleus
449:utricle
332:pattern
90:2146320
58:Aliases
1683:Q96BY6
1656:
1646:
1621:
1586:
1578:
1530:
1495:
1485:
1446:
1438:
1390:
1352:
1137:thymus
1129:spleen
1079:DOCK10
1060:Dock10
1014:search
1012:PubMed
851:Q8BZN6
832:Q96BY6
761:210293
728:Entrez
503:BioGPS
457:spleen
399:spleen
190:2q36.2
106:DOCK10
82:611518
65:DOCK10
42:DOCK10
18:DOCK10
1714:is a
1584:S2CID
1444:S2CID
1176:Cdc42
1125:brain
742:55619
721:Mouse
716:Human
687:Amigo
355:Mouse
348:Human
295:Start
230:Mouse
194:Start
127:Human
98:45952
1716:stub
1708:gene
1676:for
1654:PMID
1644:ISBN
1619:PMID
1576:PMID
1528:PMID
1493:PMID
1436:PMID
1388:PMID
1350:PMID
1207:IL-4
1198:and
1182:and
1180:TC10
1135:and
1133:lung
1086:DOCK
1082:gene
338:Bgee
286:Band
247:Chr.
185:Band
144:Chr.
78:OMIM
1674:PDB
1636:doi
1609:doi
1605:118
1568:doi
1556:579
1520:doi
1483:PMC
1475:doi
1471:409
1428:doi
1416:579
1380:doi
1340:doi
1336:115
1184:TCL
308:End
207:End
110:OMA
86:MGI
1761::
1680::
1652:.
1642:.
1617:.
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1599:.
1582:.
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1514:.
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1386:.
1376:45
1374:.
1362:^
1348:.
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1330:.
1297:.
1279:.
1250:^
1229:^
1217:.
1178:,
1139:.
1131:,
1127:,
1096:.
689:/
314:bp
301:bp
213:bp
200:bp
108:;
104::
100:;
96::
92:;
88::
84:;
80::
1747:e
1740:t
1733:v
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