242:
219:
116:
141:
500:
493:
248:
147:
1790:
1058:. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the
1670:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
1096:
One lone missense mutation in Dyrk1B gene (R102C) was found associated with an autosomal dominant early onset
Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus - seen in subjects from a nomadic group in Iran.
1560:
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry".
1671:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
255:
154:
1209:
Leder S, Weber Y, Altafaj X, Estivill X, Joost HG, Becker W (Feb 1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases".
1716:
Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E (2006). "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma".
1493:"Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M."
1345:"Identification of a Novel Disease Gene for Early Onset Atherosclerosis, Diabetes and Metabolic Syndrome by Whole Exome Sequencing and Linkage Analysis"
733:
77:
1304:"Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M"
714:
1400:
Lee K, Deng X, Friedman E (2000). "Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells".
1371:
Mercer SE, Friedman E (2006). "Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival".
1859:
1835:
1854:
1191:
1173:
241:
973:
980:
218:
1247:
1160:
1139:
1747:"Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells"
140:
115:
1156:
1344:
1135:
1592:"Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation"
57:
1071:
254:
153:
1828:
247:
146:
782:
65:
763:
759:
1821:
129:
1745:
Takahashi-Yanaga F, Mori J, Matsuzaki E, Watanabe Y, Hirata M, Miwa Y, Morimoto S, Sasaguri T (2007).
1680:
1423:"Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha"
1263:"Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha"
44:
952:
948:
885:
881:
927:
1704:
89:
956:
923:
919:
915:
889:
860:
856:
852:
499:
492:
1768:
1733:
1696:
1658:
1613:
1578:
1548:
1513:
1479:
1444:
1409:
1388:
1325:
1284:
1226:
37:
1758:
1725:
1688:
1648:
1638:
1603:
1570:
1538:
1503:
1469:
1434:
1380:
1315:
1274:
1218:
1059:
334:
265:
209:
164:
85:
309:
1684:
1805:
1653:
1626:
1248:"Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B"
1055:
1527:"Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases"
1458:"The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase"
648:
643:
638:
633:
628:
623:
618:
602:
586:
581:
576:
571:
566:
561:
556:
551:
546:
541:
1848:
1801:
528:
69:
1708:
327:
106:
1729:
93:
1196:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1178:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1384:
410:
226:
123:
73:
1627:"Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts"
1136:
ENSG00000281320 GRCh38: Ensembl release 89: ENSG00000105204, ENSG00000281320
678:
470:
348:
293:
280:
192:
179:
81:
48:, AOMS3, MIRK, dual specificity tyrosine phosphorylation regulated kinase 1B
1772:
1763:
1746:
1737:
1700:
1662:
1643:
1617:
1608:
1591:
1582:
1552:
1543:
1526:
1517:
1508:
1492:
1483:
1474:
1457:
1448:
1439:
1422:
1413:
1392:
1329:
1320:
1303:
1288:
1279:
1262:
1222:
1230:
1020:
1015:
1004:
827:
808:
1692:
794:
745:
1574:
1106:
1084:
1036:
988:
700:
1789:
1111:
1078:
1625:
Mercer SE, Ewton DZ, Deng X, Lim S, Mazur TR, Friedman E (2005).
663:
659:
1797:
1043:
61:
508:
1033:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
317:
1809:
482:
1302:
Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003).
941:
908:
874:
845:
619:
positive regulation of transcription, DNA-templated
1152:
1150:
1148:
1131:
1129:
1127:
557:protein serine/threonine/tyrosine kinase activity
264:
163:
1590:Deng X, Ewton DZ, Mercer SE, Friedman E (2005).
1491:Zou Y, Lim S, Lee K, Deng X, Friedman E (2004).
16:Protein-coding gene in the species Homo sapiens
1157:GRCm38: Ensembl release 89: ENSMUSG00000002409
1829:
8:
1836:
1822:
674:
524:
305:
204:
101:
1762:
1652:
1642:
1607:
1542:
1507:
1473:
1438:
1319:
1278:
1054:DYRK1B is a member of the DYRK family of
1242:
1240:
562:protein serine/threonine kinase activity
1123:
18:
1261:Lim S, Jin K, Friedman E (Jul 2002).
269:
230:
225:
168:
127:
122:
7:
1786:
1784:
938:
905:
871:
842:
818:
799:
773:
750:
724:
705:
552:transcription coactivator activity
487:
405:
343:
322:
14:
1456:Lim S, Zou Y, Friedman E (2003).
1421:Lim S, Jin K, Friedman E (2002).
1343:Keramati AR; et al. (2013).
1039:that in humans is encoded by the
629:peptidyl-tyrosine phosphorylation
1788:
567:protein tyrosine kinase activity
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1525:Skurat AV, Dietrich AD (2004).
1860:Human chromosome 19 gene stubs
509:More reference expression data
471:More reference expression data
1:
1730:10.1158/0008-5472.CAN-05-3089
238:
137:
1855:Genes on human chromosome 19
1808:. You can help Knowledge by
649:protein autophosphorylation
1876:
1783:
1211:Biochem Biophys Res Commun
639:adipose tissue development
1192:"Mouse PubMed Reference:"
1174:"Human PubMed Reference:"
1070:DYRK1B has been shown to
1019:
1014:
1010:
1003:
987:
968:
945:
912:
901:
878:
849:
838:
825:
821:
806:
802:
793:
780:
776:
757:
753:
744:
731:
727:
712:
708:
699:
684:
677:
673:
657:
527:
523:
506:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
974:Chr 19: 39.83 – 39.83 Mb
981:Chr 7: 27.88 – 27.89 Mb
624:protein phosphorylation
547:protein kinase activity
1764:10.1074/jbc.M605205200
1644:10.1074/jbc.M413594200
1609:10.1074/jbc.M411894200
1544:10.1074/jbc.M301769200
1509:10.1074/jbc.M307556200
1475:10.1074/jbc.M206840200
1440:10.1074/jbc.M203257200
1321:10.1074/jbc.M307556200
1280:10.1074/jbc.M203257200
1223:10.1006/bbrc.1998.9967
453:skeletal muscle tissue
449:superior frontal gyrus
437:neural layer of retina
363:skeletal muscle tissue
1373:Cell Biochem. Biophys
1092:Clinical significance
130:Chromosome 19 (human)
1385:10.1385/CBB:45:3:303
542:transferase activity
395:right adrenal cortex
375:gastrocnemius muscle
232:Chromosome 7 (mouse)
1693:10.1038/nature04209
1685:2005Natur.437.1173R
433:seminiferous tubule
387:right adrenal gland
1796:This article on a
783:ENSMUSG00000002409
612:Biological process
596:Cellular component
572:nucleotide binding
535:Molecular function
391:anterior pituitary
379:right uterine tube
94:DYRK1B - orthologs
1817:
1816:
1637:(27): 25788–801.
1575:10.1021/ac035352d
1030:
1029:
1026:
1025:
999:
998:
964:
963:
935:
934:
897:
896:
868:
867:
834:
833:
815:
814:
789:
788:
770:
769:
740:
739:
721:
720:
669:
668:
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1867:
1838:
1831:
1824:
1792:
1785:
1776:
1766:
1757:(50): 38489–97.
1741:
1712:
1679:(7062): 1173–8.
1666:
1656:
1646:
1621:
1611:
1586:
1556:
1546:
1521:
1511:
1502:(49): 49573–81.
1487:
1477:
1468:(51): 49438–45.
1452:
1442:
1417:
1396:
1357:
1356:
1355:(22 Supplement).
1340:
1334:
1333:
1323:
1314:(49): 49573–81.
1299:
1293:
1292:
1282:
1258:
1252:
1251:
1244:
1235:
1234:
1206:
1200:
1199:
1188:
1182:
1181:
1170:
1164:
1154:
1143:
1133:
1060:catalytic domain
1012:
1011:
983:
976:
959:
939:
930:
906:
902:RefSeq (protein)
892:
872:
863:
843:
819:
800:
774:
751:
725:
706:
675:
525:
511:
502:
495:
488:
473:
441:genital tubercle
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1875:
1874:
1870:
1869:
1868:
1866:
1865:
1864:
1845:
1844:
1843:
1842:
1781:
1779:
1744:
1715:
1669:
1624:
1602:(6): 4894–905.
1589:
1569:(10): 2763–72.
1559:
1524:
1490:
1455:
1433:(28): 25040–6.
1420:
1399:
1370:
1366:
1364:Further reading
1361:
1360:
1342:
1341:
1337:
1301:
1300:
1296:
1273:(28): 25040–6.
1260:
1259:
1255:
1246:
1245:
1238:
1208:
1207:
1203:
1190:
1189:
1185:
1172:
1171:
1167:
1155:
1146:
1134:
1125:
1120:
1103:
1094:
1068:
1056:protein kinases
1052:
1021:View/Edit Mouse
1016:View/Edit Human
979:
972:
969:Location (UCSC)
955:
951:
947:
926:
922:
918:
914:
888:
884:
880:
859:
855:
851:
764:ENSG00000281320
762:
760:ENSG00000105204
653:
644:phosphorylation
634:myoblast fusion
607:
591:
587:kinase activity
577:protein binding
507:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
425:muscle of thigh
423:
409:
398:
393:
389:
385:
383:pituitary gland
381:
377:
373:
369:
365:
361:
359:muscle of thigh
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1873:
1871:
1863:
1862:
1857:
1847:
1846:
1841:
1840:
1833:
1826:
1818:
1815:
1814:
1793:
1778:
1777:
1742:
1724:(8): 4149–58.
1713:
1667:
1622:
1587:
1557:
1522:
1488:
1453:
1418:
1408:(13): 3631–7.
1397:
1367:
1365:
1362:
1359:
1358:
1335:
1294:
1253:
1236:
1201:
1183:
1165:
1144:
1122:
1121:
1119:
1116:
1115:
1114:
1109:
1102:
1099:
1093:
1090:
1089:
1088:
1082:
1067:
1064:
1051:
1048:
1028:
1027:
1024:
1023:
1018:
1008:
1007:
1001:
1000:
997:
996:
994:
992:
985:
984:
977:
970:
966:
965:
962:
961:
943:
942:
936:
933:
932:
910:
909:
903:
899:
898:
895:
894:
876:
875:
869:
866:
865:
847:
846:
840:
836:
835:
832:
831:
823:
822:
816:
813:
812:
804:
803:
797:
791:
790:
787:
786:
778:
777:
771:
768:
767:
755:
754:
748:
742:
741:
738:
737:
729:
728:
722:
719:
718:
710:
709:
703:
697:
696:
691:
686:
682:
681:
671:
670:
667:
666:
655:
654:
652:
651:
646:
641:
636:
631:
626:
621:
615:
613:
609:
608:
606:
605:
599:
597:
593:
592:
590:
589:
584:
579:
574:
569:
564:
559:
554:
549:
544:
538:
536:
532:
531:
521:
520:
517:
516:
513:
512:
504:
503:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1872:
1861:
1858:
1856:
1853:
1852:
1850:
1839:
1834:
1832:
1827:
1825:
1820:
1819:
1813:
1811:
1807:
1803:
1802:chromosome 19
1799:
1794:
1791:
1787:
1782:
1774:
1770:
1765:
1760:
1756:
1752:
1751:J. Biol. Chem
1748:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1668:
1664:
1660:
1655:
1650:
1645:
1640:
1636:
1632:
1631:J. Biol. Chem
1628:
1623:
1619:
1615:
1610:
1605:
1601:
1597:
1596:J. Biol. Chem
1593:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1558:
1554:
1550:
1545:
1540:
1537:(4): 2490–8.
1536:
1532:
1531:J. Biol. Chem
1528:
1523:
1519:
1515:
1510:
1505:
1501:
1497:
1496:J. Biol. Chem
1494:
1489:
1485:
1481:
1476:
1471:
1467:
1463:
1462:J. Biol. Chem
1459:
1454:
1450:
1446:
1441:
1436:
1432:
1428:
1427:J. Biol. Chem
1424:
1419:
1415:
1411:
1407:
1403:
1398:
1394:
1390:
1386:
1382:
1379:(3): 303–15.
1378:
1374:
1369:
1368:
1363:
1354:
1350:
1346:
1339:
1336:
1331:
1327:
1322:
1317:
1313:
1309:
1308:J. Biol. Chem
1305:
1298:
1295:
1290:
1286:
1281:
1276:
1272:
1268:
1267:J. Biol. Chem
1264:
1257:
1254:
1249:
1243:
1241:
1237:
1232:
1228:
1224:
1220:
1216:
1212:
1205:
1202:
1197:
1193:
1187:
1184:
1179:
1175:
1169:
1166:
1162:
1158:
1153:
1151:
1149:
1145:
1141:
1137:
1132:
1130:
1128:
1124:
1117:
1113:
1110:
1108:
1105:
1104:
1100:
1098:
1091:
1086:
1083:
1080:
1077:
1076:
1075:
1073:
1065:
1063:
1061:
1057:
1049:
1047:
1045:
1042:
1038:
1034:
1022:
1017:
1013:
1009:
1006:
1002:
995:
993:
990:
986:
982:
978:
975:
971:
967:
960:
958:
954:
950:
944:
940:
937:
931:
929:
925:
921:
917:
911:
907:
904:
900:
893:
891:
887:
883:
877:
873:
870:
864:
862:
858:
854:
848:
844:
841:
839:RefSeq (mRNA)
837:
830:
829:
824:
820:
817:
811:
810:
805:
801:
798:
796:
792:
785:
784:
779:
775:
772:
766:
765:
761:
756:
752:
749:
747:
743:
736:
735:
730:
726:
723:
717:
716:
711:
707:
704:
702:
698:
695:
692:
690:
687:
683:
680:
676:
672:
665:
661:
656:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
616:
614:
611:
610:
604:
601:
600:
598:
595:
594:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
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1810:expanding it
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1217:(2): 474–9.
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1069:
1066:Interactions
1053:
1040:
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1031:
953:NP_001258299
949:NP_001033046
946:
913:
886:NM_001271370
882:NM_001037957
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850:
826:
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732:
713:
693:
688:
429:spermatocyte
367:right testis
333:
326:
53:External IDs
1349:Circulation
928:NP_004705.1
582:ATP binding
457:granulocyte
371:left testis
292:27,886,719
279:27,878,894
271:7|7 A3
191:39,834,201
178:39,825,350
31:Identifiers
1849:Categories
1718:Cancer Res
1563:Anal. Chem
1402:Cancer Res
1163:, May 2017
1142:, May 2017
1118:References
337:(ortholog)
74:HomoloGene
1800:on human
957:NP_034222
924:NP_006475
920:NP_006474
916:NP_004705
890:NM_010092
861:NM_006484
857:NM_006483
853:NM_004714
679:Orthologs
421:spermatid
82:GeneCards
1773:17046823
1738:16618736
1701:16189514
1663:15851482
1618:15546868
1583:15144186
1553:14593110
1518:14500717
1484:12384504
1449:11980910
1414:10910078
1393:16845176
1330:14500717
1289:11980910
1159:–
1138:–
1101:See also
1072:interact
1050:Function
1005:Wikidata
658:Sources:
1709:4427026
1681:Bibcode
1654:1201501
1231:9918863
1161:Ensembl
1140:Ensembl
795:UniProt
746:Ensembl
685:Species
664:QuickGO
603:nucleus
312:pattern
170:19q13.2
70:1330302
38:Aliases
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1673:Nature
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1107:DYRK1A
1085:RANBP9
1074:with:
1041:DYRK1B
1037:enzyme
1035:is an
991:search
989:PubMed
828:Q9Z188
809:Q9Y463
701:Entrez
483:BioGPS
86:DYRK1B
62:604556
45:DYRK1B
22:DYRK1B
1804:is a
1705:S2CID
1112:DYRK2
1079:PCBD1
734:13549
694:Mouse
689:Human
660:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:31253
1806:stub
1798:gene
1769:PMID
1734:PMID
1697:PMID
1659:PMID
1614:PMID
1579:PMID
1549:PMID
1514:PMID
1480:PMID
1445:PMID
1410:PMID
1389:PMID
1326:PMID
1285:PMID
1227:PMID
1044:gene
715:9149
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1759:doi
1755:281
1726:doi
1689:doi
1677:437
1649:PMC
1639:doi
1635:280
1604:doi
1600:280
1571:doi
1539:doi
1535:279
1504:doi
1500:278
1470:doi
1466:277
1435:doi
1431:277
1381:doi
1353:128
1316:doi
1312:278
1275:doi
1271:277
1219:doi
1215:254
1081:and
445:lip
288:End
187:End
90:OMA
66:MGI
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