242:
219:
116:
141:
493:
248:
147:
1567:
1110:
residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to
255:
154:
1249:"Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases"
806:
77:
787:
1312:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1636:
1229:
1612:
1211:
1631:
1353:
Zhang D, Li K, Erickson-Miller CL, et al. (2005). "DYRK gene structure and erythroid-restricted features of DYRK3 gene expression".
1014:
241:
1021:
1474:"DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survival"
218:
1291:
1198:
1177:
1091:
1194:
140:
115:
1173:
57:
1382:
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".
254:
153:
247:
146:
1605:
851:
65:
832:
1127:
1598:
1432:
129:
1507:
Lord KA, Creasy CL, King AG, et al. (2000). "REDK, a novel human regulatory erythroid kinase".
44:
1095:
972:
921:
1407:
89:
1421:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
997:
976:
946:
925:
1545:
1524:
1520:
1495:
1460:
1399:
1370:
1341:
1270:
1112:
492:
37:
1516:
1485:
1450:
1440:
1391:
1362:
1331:
1323:
1260:
334:
265:
209:
164:
85:
309:
48:, DYRK5, RED, REDK, hYAK3-2, dual specificity tyrosine phosphorylation regulated kinase 3
1436:
1582:
1336:
1311:
1455:
1420:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
579:
574:
569:
564:
559:
554:
549:
544:
539:
534:
1625:
1292:"Entrez Gene: DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3"
687:
negative regulation of DNA damage response, signal transduction by p53 class mediator
521:
69:
1578:
1411:
327:
106:
93:
1366:
1234:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1216:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1123:
410:
1119:
226:
123:
73:
1265:
1248:
1103:
751:
470:
348:
293:
280:
192:
179:
81:
1528:
1499:
1490:
1473:
1464:
1445:
1403:
1374:
1345:
1549:
1274:
1247:
Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor FJ, Joost HG (Nov 1998).
1061:
1056:
1107:
1045:
896:
877:
1327:
1116:
863:
818:
1130:
transcript variants encoding different isoforms have been identified.
1144:
1139:
1099:
1077:
1029:
773:
1566:
1395:
1149:
736:
732:
1574:
1084:
61:
501:
1074:
Dual specificity tyrosine-phosphorylation-regulated kinase 3
1419:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
317:
1586:
717:
positive regulation of cell cycle G2/M phase transition
1310:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
482:
1115:
on tyrosine residue and catalyze phosphorylation of
990:
965:
939:
914:
1190:
1188:
1186:
1169:
1167:
1165:
545:protein serine/threonine/tyrosine kinase activity
264:
163:
1090:This gene product belongs to the DYRK family of
1536:Xia J, Yang X, Ruan Q, et al. (1999). "".
16:Protein-coding gene in the species Homo sapiens
1195:GRCm38: Ensembl release 89: ENSMUSG00000016526
1606:
1472:Li K, Zhao S, Karur V, Wojchowski DM (2003).
8:
1174:GRCh38: Ensembl release 89: ENSG00000143479
1613:
1599:
747:
517:
305:
204:
101:
1521:10.1182/blood.V95.9.2838.009k29_2838_2846
1489:
1454:
1444:
1335:
1264:
692:regulation of cellular response to stress
429:fetal liver hematopoietic progenitor cell
1286:
1284:
682:negative regulation of apoptotic process
611:intracellular membrane-bounded organelle
580:protein serine/threonine kinase activity
1161:
18:
269:
230:
225:
168:
127:
122:
7:
1563:
1561:
1538:Zhonghua Yi Xue Yi Chuan Xue Za Zhi
987:
962:
936:
911:
887:
868:
842:
823:
797:
778:
487:
405:
343:
322:
14:
1080:that in humans is encoded by the
667:peptidyl-tyrosine phosphorylation
1565:
1092:dual-specificity protein kinases
550:protein tyrosine kinase activity
491:
253:
246:
240:
217:
152:
145:
139:
114:
502:More reference expression data
471:More reference expression data
1:
1637:Human chromosome 1 gene stubs
697:regulation of TORC1 signaling
631:microtubule organizing center
238:
137:
1585:. You can help Knowledge by
1425:Proc. Natl. Acad. Sci. U.S.A
1632:Genes on human chromosome 1
1367:10.1016/j.ygeno.2004.08.021
657:erythrocyte differentiation
387:stromal cell of endometrium
1653:
1560:
707:nuclear speck organization
677:stress granule disassembly
621:cytoplasmic stress granule
1230:"Mouse PubMed Reference:"
1212:"Human PubMed Reference:"
1060:
1055:
1051:
1044:
1028:
1022:Chr 1: 131.06 – 131.07 Mb
1015:Chr 1: 206.64 – 206.68 Mb
1009:
994:
969:
958:
943:
918:
907:
894:
890:
875:
871:
862:
849:
845:
830:
826:
817:
804:
800:
785:
781:
772:
757:
750:
746:
730:
520:
516:
499:
490:
481:
468:
417:
408:
395:mucosa of urinary bladder
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1266:10.1074/jbc.273.40.25893
662:protein phosphorylation
626:pericentriolar material
540:protein kinase activity
1491:10.1074/jbc.M205374200
1446:10.1073/pnas.242603899
437:respiratory epithelium
1128:Alternatively spliced
722:organelle disassembly
565:magnesium ion binding
535:transferase activity
453:facial motor nucleus
445:olfactory epithelium
232:Chromosome 1 (mouse)
130:Chromosome 1 (human)
1437:2002PNAS...9916899M
1096:autophosphorylation
421:seminiferous tubule
1573:This article on a
1328:10.1101/gr.4039406
852:ENSMUSG00000016526
650:Biological process
589:Cellular component
555:nucleotide binding
528:Molecular function
1594:
1593:
1431:(26): 16899–903.
1259:(40): 25893–902.
1113:autophosphorylate
1071:
1070:
1067:
1066:
1040:
1039:
1005:
1004:
984:
983:
954:
953:
933:
932:
903:
902:
884:
883:
858:
857:
839:
838:
813:
812:
794:
793:
742:
741:
570:metal ion binding
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:DYRK3 - orthologs
1644:
1615:
1608:
1601:
1569:
1562:
1553:
1532:
1503:
1493:
1484:(49): 47052–60.
1468:
1458:
1448:
1415:
1378:
1349:
1339:
1296:
1295:
1288:
1279:
1278:
1268:
1244:
1238:
1237:
1226:
1220:
1219:
1208:
1202:
1192:
1181:
1171:
1053:
1052:
1024:
1017:
1000:
988:
979:
963:
959:RefSeq (protein)
949:
937:
928:
912:
888:
869:
843:
824:
798:
779:
748:
518:
504:
495:
488:
473:
457:ventricular zone
441:nasal epithelium
413:
411:Top expressed in
406:
383:cartilage tissue
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1652:
1651:
1647:
1646:
1645:
1643:
1642:
1641:
1622:
1621:
1620:
1619:
1558:
1556:
1535:
1506:
1471:
1418:
1396:10.1038/nbt1046
1384:Nat. Biotechnol
1381:
1352:
1309:
1305:
1303:Further reading
1300:
1299:
1290:
1289:
1282:
1246:
1245:
1241:
1228:
1227:
1223:
1210:
1209:
1205:
1193:
1184:
1172:
1163:
1158:
1136:
1062:View/Edit Mouse
1057:View/Edit Human
1020:
1013:
1010:Location (UCSC)
996:
975:
971:
945:
924:
920:
833:ENSG00000143479
726:
672:phosphorylation
645:
584:
575:kinase activity
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1650:
1648:
1640:
1639:
1634:
1624:
1623:
1618:
1617:
1610:
1603:
1595:
1592:
1591:
1570:
1555:
1554:
1533:
1515:(9): 2838–46.
1504:
1469:
1416:
1379:
1350:
1306:
1304:
1301:
1298:
1297:
1280:
1239:
1221:
1203:
1182:
1160:
1159:
1157:
1154:
1153:
1152:
1147:
1142:
1135:
1132:
1094:that catalyze
1069:
1068:
1065:
1064:
1059:
1049:
1048:
1042:
1041:
1038:
1037:
1035:
1033:
1026:
1025:
1018:
1011:
1007:
1006:
1003:
1002:
992:
991:
985:
982:
981:
967:
966:
960:
956:
955:
952:
951:
941:
940:
934:
931:
930:
916:
915:
909:
905:
904:
901:
900:
892:
891:
885:
882:
881:
873:
872:
866:
860:
859:
856:
855:
847:
846:
840:
837:
836:
828:
827:
821:
815:
814:
811:
810:
802:
801:
795:
792:
791:
783:
782:
776:
770:
769:
764:
759:
755:
754:
744:
743:
740:
739:
728:
727:
725:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
653:
651:
647:
646:
644:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
592:
590:
586:
585:
583:
582:
577:
572:
567:
562:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
371:male germ cell
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1649:
1638:
1635:
1633:
1630:
1629:
1627:
1616:
1611:
1609:
1604:
1602:
1597:
1596:
1590:
1588:
1584:
1580:
1576:
1571:
1568:
1564:
1559:
1551:
1547:
1544:(6): 327–32.
1543:
1539:
1534:
1530:
1526:
1522:
1518:
1514:
1510:
1505:
1501:
1497:
1492:
1487:
1483:
1479:
1478:J. Biol. Chem
1475:
1470:
1466:
1462:
1457:
1452:
1447:
1442:
1438:
1434:
1430:
1426:
1422:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1390:(1): 94–101.
1389:
1385:
1380:
1376:
1372:
1368:
1364:
1361:(1): 117–30.
1360:
1356:
1351:
1347:
1343:
1338:
1333:
1329:
1325:
1321:
1317:
1313:
1308:
1307:
1302:
1293:
1287:
1285:
1281:
1276:
1272:
1267:
1262:
1258:
1254:
1250:
1243:
1240:
1235:
1231:
1225:
1222:
1217:
1213:
1207:
1204:
1200:
1196:
1191:
1189:
1187:
1183:
1179:
1175:
1170:
1168:
1166:
1162:
1155:
1151:
1148:
1146:
1143:
1141:
1138:
1137:
1133:
1131:
1129:
1125:
1121:
1118:
1114:
1109:
1105:
1101:
1097:
1093:
1088:
1086:
1083:
1079:
1075:
1063:
1058:
1054:
1050:
1047:
1043:
1036:
1034:
1031:
1027:
1023:
1019:
1016:
1012:
1008:
1001:
999:
993:
989:
986:
980:
978:
974:
968:
964:
961:
957:
950:
948:
942:
938:
935:
929:
927:
923:
917:
913:
910:
908:RefSeq (mRNA)
906:
899:
898:
893:
889:
886:
880:
879:
874:
870:
867:
865:
861:
854:
853:
848:
844:
841:
835:
834:
829:
825:
822:
820:
816:
809:
808:
803:
799:
796:
790:
789:
784:
780:
777:
775:
771:
768:
765:
763:
760:
756:
753:
749:
745:
738:
734:
729:
723:
720:
718:
715:
713:
712:cell division
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
654:
652:
649:
648:
642:
641:nuclear speck
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
593:
591:
588:
587:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
449:parotid gland
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
391:apex of heart
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1587:expanding it
1579:chromosome 1
1572:
1557:
1541:
1537:
1512:
1508:
1481:
1477:
1428:
1424:
1387:
1383:
1358:
1354:
1322:(1): 55–65.
1319:
1315:
1256:
1252:
1242:
1233:
1224:
1215:
1206:
1089:
1081:
1073:
1072:
995:
973:NP_001004023
970:
944:
922:NM_001004023
919:
895:
876:
850:
831:
805:
786:
766:
761:
636:cytoskeleton
433:spermatocyte
367:right testis
333:
326:
292:131,066,077
279:131,055,192
191:206,684,419
178:206,635,536
53:External IDs
1253:J Biol Chem
601:nucleoplasm
560:ATP binding
363:left testis
271:1|1 E4
31:Identifiers
1626:Categories
1316:Genome Res
1201:, May 2017
1180:, May 2017
1156:References
1126:in vitro.
702:cell cycle
337:(ortholog)
74:HomoloGene
1577:on human
1104:threonine
998:NP_663483
977:NP_003573
947:NM_145508
926:NM_003582
752:Orthologs
616:cytoplasm
425:spermatid
379:vena cava
359:beta cell
82:GeneCards
1529:10779429
1500:12356771
1465:12477932
1404:15592455
1375:15607427
1355:Genomics
1346:16344560
1197:–
1176:–
1134:See also
1117:histones
1108:tyrosine
1046:Wikidata
731:Sources:
1550:9845759
1433:Bibcode
1412:7200157
1337:1356129
1275:9748265
1199:Ensembl
1178:Ensembl
864:UniProt
819:Ensembl
758:Species
737:QuickGO
606:cytosol
596:nucleus
312:pattern
70:1330300
38:Aliases
1548:
1527:
1498:
1463:
1456:139241
1453:
1410:
1402:
1373:
1344:
1334:
1273:
1145:DYRK1B
1140:DYRK1A
1100:serine
1078:enzyme
1076:is an
1032:search
1030:PubMed
897:Q922Y0
878:O43781
807:226419
774:Entrez
483:BioGPS
170:1q32.1
62:603497
1581:is a
1509:Blood
1408:S2CID
1150:DYRK2
1082:DYRK3
767:Mouse
762:Human
733:Amigo
375:sperm
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:DYRK3
78:55762
45:DYRK3
22:DYRK3
1583:stub
1575:gene
1546:PMID
1525:PMID
1496:PMID
1461:PMID
1400:PMID
1371:PMID
1342:PMID
1271:PMID
1122:and
1106:and
1085:gene
788:8444
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1517:doi
1486:doi
1482:277
1451:PMC
1441:doi
1392:doi
1363:doi
1332:PMC
1324:doi
1261:doi
1257:273
1124:H2B
1098:on
288:End
187:End
90:OMA
66:MGI
1628::
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1283:^
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1164:^
1120:H3
1087:.
735:/
294:bp
281:bp
193:bp
180:bp
88:;
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