466:(pNET) had initially reported results, but was later terminated because insufficient normal tissue tolerance to the drug. A phase I clinical trial of BEZ235 in patients with advanced renal cell carcinoma had to be terminated prematurely due to toxicity and a lack of clinical efficacy . Another Phase Ib study on patients with various solid cancers found severe normal tissue toxicity as well when BEZ235/Dactolisib was administered in combination with the mTOR inhibitor Everolimus. The authors concluded that the combination of both drugs demonstrated limited efficacy and tolerance. BEZ235 systemic exposure increased in a dose-proportional manner while oral bioavailability was quite low, which may be related to gastrointestinal-specific toxicity . A phase I study of BEZ-235 to treat acute lymphoid leukaemia was initiated in 2012, but no results were published since then.
266:
33:
2597:
24:
383:
542:
Awasthi, N; Yen, PL; Schwarz, MA; Schwarz, RE (March 2012). "The
Efficacy of a Novel, Dual PI3K/mTOR Inhibitor NVP-BEZ235 to Enhance Chemotherapy and Antiangiogenic Response in Pancreatic Cancer".
2689:
396:
105:
2645:
877:
2674:
1577:
305:
495:"NVP-BEZ235, a Novel Dual Phosphatidylinositol 3-kinase/Mammalian Target of Rapamycin Inhibitor, Elicits Multifaceted Antitumor Activities in Human Gliomas"
811:"Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections"
289:
InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
2638:
2553:
870:
446:
763:"A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib(BEZ235) Combined with Everolimus in Patients with AdvancedSolid Malignancies"
2160:
585:
Maira, SM; Stauffer, F; Schnell, C; García-Echeverría, C (1 February 2009). "PI3K Inhibitors for Cancer
Treatment: Where Do We Stand?".
2664:
1312:
1268:
1146:
2631:
1071:
280:
863:
702:
BEZ235 Phase II Trial in
Patients With Advanced Pancreatic Neuroendocrine Tumors (pNET) After Failure of mTOR Inhibitor Therapy.
1793:
1587:
463:
439:
2206:
1208:
1098:
167:
670:"A Phase I/II Study of BEZ235 in Patients with Advanced Solid Malignancies Enriched by Patients with Advanced Breast Cancer"
2128:
2111:
1986:
1750:
1128:
403:
2684:
1860:
1456:
691:
Phase Ib/II Trial of BEZ235 With
Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer
223:
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855:
470:
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2001:
1251:
493:
Liu, TJ; Koul, D; LaFortune, T; Tiao, N; Shen, RJ; Maira, SM; Garcia-Echevrria, C; Yung, WKA (11 August 2009).
2558:
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1998:
1484:
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2086:
1928:
125:
1635:
1452:
1422:
1282:
785:"A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia"
2033:
1910:
1431:
1347:
45:
261:
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2197:
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1572:
1303:
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477:
in combination with dactolisib decreased the rate of reported infections in an elderly population.
71:
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1991:
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1002:
954:
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359:
157:
136:
622:"Role of Dual PI3/Akt and mTOR Inhibition in Waldenström's Macroglobulinemia"
2535:
2515:
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2454:
2358:
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2121:
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2049:
2011:
1939:
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1007:
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987:
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637:
473:
randomized, placebo-controlled clinical trial published in 2018 showed that
846:
748:
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1052:
913:
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199:
23:
555:
977:
762:
116:
373:
Except where otherwise noted, data are given for materials in their
452:
It was the first PI3K inhibitor to enter clinical trials, in 2006.
187:
104:
94:
455:
A phase IB/II clinical trial for locally advanced or metastatic
178:
859:
313:
N#CC(c6ccc(N5c4c(cnc3ccc(c1cc2ccccc2nc1)cc34)N(C5=O)C)cc6)(C)C
249:
442:. It is being investigated as a possible cancer treatment.
2619:
715:"BEZ235: When Promising Science Meets Clinical Reality"
391:
620:
Sacco, A; Roccaro, A; Ghobrial, IM (November 2010).
2245:
2196:
1976:
1969:
1905:
1859:
1792:
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1586:
1571:
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1421:
1346:
1331:
1302:
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1118:
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1044:
1033:
969:
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903:
166:
50:2-Methyl-2-{4-quinolin-1-yl]phenyl}propanenitrile
211:
80:
2690:Antineoplastic and immunomodulating drug stubs
2639:
871:
8:
2646:
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1973:
1583:
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1058:
1041:
919:
878:
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856:
264:
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15:
836:
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645:
518:
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485:
462:A phase II clinical trial for advanced
310:
285:
260:
292:Key: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
124:
7:
2675:Phosphoinositide 3-kinase inhibitors
2593:
2591:
1147:ribonucleotide reductase inhibitors
202:
186:
2618:. You can help Knowledge (XXG) by
1313:Ribonucleotide reductase inhibitor
1269:Ribonucleotide reductase inhibitor
14:
1072:Dihydrofolate reductase inhibitor
445:It has been shown to be toxic to
2595:
587:Biochemical Society Transactions
544:Journal of Cellular Biochemistry
464:pancreatic neuroendocrine tumors
381:
346:
340:
31:
22:
731:10.1634/theoncologist.2016-0243
447:Waldenström's macroglobulinemia
377:(at 25 °C , 100 kPa).
1209:Thymidylate synthase inhibitor
1099:Thymidylate synthase inhibitor
352:
334:
1:
1129:Adenosine deaminase inhibitor
970:Block microtubule disassembly
713:Pongas, G.; Fojo, T. (2016).
511:10.1158/1535-7163.MCT-09-0160
499:Molecular Cancer Therapeutics
457:HER2 negative breast cancer
59:NVP-BEZ235; BEZ-235; RTB101
2706:
2590:
2665:Experimental cancer drugs
2548:
2429:Omacetaxine mepesuccinate
2309:Ciltacabtagene autoleucel
2299:Brexucabtagene autoleucel
371:
321:
301:
276:
64:
56:
44:
39:
30:
21:
2481:Talimogene laherparepvec
2414:Nadofaragene firadenovec
2384:Lisocabtagene maraleucel
1333:Topoisomerase inhibitors
1252:DNA polymerase inhibitor
2284:Axicabtagene ciloleucel
888:chemotherapeutic agents
638:10.18632/oncotarget.192
434:derivative acting as a
2466:Sitimagene ceradenovec
2364:Idecabtagene vicleucel
1929:Methyl aminolevulinate
1940:Porphyrin derivatives
1636:Melphalan flufenamide
1283:Hypomethylating agent
892:antineoplastic agents
829:10.18632/aging.102988
2269:Asparagine depleters
2198:Receptor antagonists
2112:+abiraterone acetate
672:. ClinicalTrials.gov
46:Preferred IUPAC name
2685:Phenylene compounds
2319:Denileukin diftitox
2219:Retinoid X receptor
1919:Aminolevulinic acid
1741:Triethylenemelamine
1573:Crosslinking of DNA
1304:Deoxyribonucleotide
1243:+gimeracil/oteracil
787:. clinicatrials.gov
438:. It also inhibits
367: g·mol
18:
2575:Never to phase III
1377:Etirinotecan pegol
599:10.1042/BST0370265
404:Infobox references
16:
2670:Imidazoquinolines
2627:
2626:
2585:
2584:
2544:
2543:
2501:Tigilanol tiglate
1978:Enzyme inhibitors
1901:
1900:
1897:
1896:
1597:Nitrogen mustards
1567:
1566:
1327:
1326:
1029:
1028:
765:. Target Oncology
556:10.1002/jcb.23405
426:, also known as
412:Chemical compound
410:
409:
245:CompTox Dashboard
106:Interactive image
2697:
2648:
2641:
2634:
2609:immunomodulatory
2599:
2592:
2506:Tisagenlecleucel
2263:Arsenic trioxide
1974:
1907:Photosensitizers
1698:Alkyl sulfonates
1612:Cyclophosphamide
1584:
1523:Anthracenediones
1344:
1318:Hydroxycarbamide
1059:
1042:
920:
880:
873:
866:
857:
851:
850:
840:
823:(8): 6492–6510.
803:
797:
796:
794:
792:
781:
775:
774:
772:
770:
759:
753:
752:
742:
725:(9): 1033–1034.
710:
704:
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688:
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681:
679:
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666:
660:
659:
649:
617:
611:
610:
582:
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533:
532:
522:
490:
432:imidazoquinoline
394:
388:
385:
384:
366:
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342:
336:
329:Chemical formula
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84:
35:
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19:
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2694:
2655:
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2653:
2652:
2588:
2586:
2581:
2580:
2565:Clinical trials
2540:
2246:Other/ungrouped
2241:
2192:
1965:
1945:Porfimer sodium
1893:
1855:
1788:
1745:
1575:
1563:
1447:
1417:
1335:
1323:
1298:
1194:
1114:
1050:
1048:antimetabolites
1046:
1045:DNA precursors/
1037:
1035:DNA replication
1025:
965:
935:Vinca alkaloids
911:
899:
884:
854:
805:
804:
800:
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788:
783:
782:
778:
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619:
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584:
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579:
541:
540:
536:
492:
491:
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483:
459:has completed.
413:
406:
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399: ?)
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60:
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12:
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5:
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2672:
2667:
2657:
2656:
2651:
2650:
2643:
2636:
2628:
2625:
2624:
2605:antineoplastic
2600:
2583:
2582:
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2200:
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2179:
2174:
2169:
2157:
2151:
2146:
2141:
2136:
2125:
2119:
2114:
2106:
2099:PARP inhibitor
2095:
2083:
2071:
2059:
2058:
2057:
2052:
2047:
2042:
2030:
2024:
2019:
2014:
2009:
1995:
1982:
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1971:
1967:
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1790:
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1761:
1755:
1753:
1751:Platinum-based
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1535:
1530:
1519:
1513:
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1498:
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1478:
1473:
1466:Anthracyclines
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1459:
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1202:
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1186:
1184:Mercaptopurine
1175:
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1024:
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1005:
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928:
917:
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886:Intracellular
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883:
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868:
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852:
798:
776:
754:
719:The Oncologist
705:
694:
683:
661:
612:
577:
534:
505:(8): 2204–10.
484:
482:
479:
436:PI3K inhibitor
411:
408:
407:
402:
380:
379:
375:standard state
372:
369:
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262:DTXSID10238599
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2660:
2649:
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2637:
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2623:
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2617:
2614:article is a
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2524:
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2514:
2512:
2509:
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2504:
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2499:
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2469:
2467:
2464:
2462:
2459:
2456:
2453:
2451:
2447:
2446:
2442:
2440:
2439:Tabelecleucel
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
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2402:
2400:
2399:Lurbinectedin
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2395:
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2380:
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2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2279:
2275:
2271:
2270:
2266:
2264:
2261:
2259:
2256:
2254:
2251:
2250:
2248:
2244:
2237:
2233:
2232:
2228:
2225:
2221:
2220:
2216:
2213:
2209:
2208:
2204:
2203:
2201:
2199:
2195:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2164:
2162:
2158:
2155:
2152:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2131:
2130:
2126:
2123:
2120:
2118:
2115:
2113:
2110:
2107:
2105:
2101:
2100:
2096:
2093:
2089:
2088:
2084:
2081:
2077:
2076:
2072:
2069:
2065:
2064:
2060:
2056:
2053:
2051:
2048:
2046:
2043:
2041:
2038:
2037:
2036:
2035:
2031:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2008:
2004:
2003:
2000:
1996:
1993:
1989:
1988:
1984:
1983:
1981:
1979:
1975:
1972:
1968:
1961:
1958:
1956:
1953:
1951:
1948:
1946:
1942:
1941:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1920:
1917:
1916:
1914:
1912:
1908:
1904:
1889:
1886:
1884:
1881:
1879:
1876:
1874:
1870:
1867:
1866:
1864:
1862:
1861:Intercalation
1858:
1851:
1848:
1846:
1843:
1841:
1837:
1836:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1814:
1810:
1809:
1805:
1803:
1800:
1799:
1797:
1795:
1791:
1785:
1782:
1780:
1777:
1775:
1772:
1770:
1769:Dicycloplatin
1767:
1765:
1762:
1760:
1757:
1756:
1754:
1752:
1748:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1718:
1717:
1713:
1710:
1708:
1704:
1701:
1699:
1695:
1694:
1691:
1688:
1686:
1683:
1681:
1678:
1675:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1652:
1651:
1648:
1645:
1643:
1642:Prednimustine
1640:
1637:
1633:
1630:
1628:
1625:
1622:
1619:
1617:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1594:
1593:
1591:
1589:
1585:
1582:
1579:
1574:
1570:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1542:
1539:
1536:
1534:
1531:
1529:
1525:
1524:
1520:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1486:
1482:
1479:
1477:
1474:
1472:
1468:
1467:
1463:
1462:
1460:
1458:
1457:Intercalation
1454:
1450:
1443:
1440:
1438:
1434:
1433:
1429:
1428:
1426:
1424:
1420:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1373:
1370:
1368:
1365:
1363:
1359:
1358:
1354:
1353:
1351:
1349:
1345:
1342:
1339:
1334:
1330:
1319:
1315:
1314:
1310:
1309:
1307:
1305:
1301:
1294:
1291:
1289:
1285:
1284:
1280:
1279:
1275:
1271:
1270:
1266:
1265:
1261:
1260:+daunorubicin
1258:
1254:
1253:
1249:
1248:
1244:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1224:Doxifluridine
1222:
1220:
1217:
1215:
1211:
1210:
1206:
1205:
1203:
1201:
1197:
1190:
1187:
1185:
1181:
1180:
1176:
1174:
1173:Rabacfosadine
1171:
1169:
1166:
1163:
1160:
1158:
1155:
1153:
1149:
1148:
1144:
1140:
1139:
1135:
1131:
1130:
1126:
1125:
1123:
1121:
1117:
1110:
1107:
1105:
1101:
1100:
1096:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1074:
1073:
1069:
1068:
1066:
1064:
1060:
1057:
1054:
1049:
1043:
1040:
1036:
1032:
1021:
1017:
1016:
1012:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
980:
979:
975:
974:
972:
968:
961:
958:
956:
953:
951:
948:
946:
943:
941:
937:
936:
932:
931:
929:
926:
921:
918:
915:
910:
906:
902:
897:
893:
889:
881:
876:
874:
869:
867:
862:
861:
858:
848:
844:
839:
834:
830:
826:
822:
818:
817:
812:
808:
807:Zhavoronkov A
802:
799:
786:
780:
777:
764:
758:
755:
750:
746:
741:
736:
732:
728:
724:
720:
716:
709:
706:
703:
698:
695:
692:
687:
684:
671:
665:
662:
657:
653:
648:
643:
639:
635:
632:(7): 578–82.
631:
627:
623:
616:
613:
608:
604:
600:
596:
593:(1): 265–72.
592:
588:
581:
578:
573:
569:
565:
561:
557:
553:
550:(3): 784–91.
549:
545:
538:
535:
530:
526:
521:
516:
512:
508:
504:
500:
496:
489:
486:
480:
478:
476:
472:
467:
465:
460:
458:
453:
450:
448:
443:
441:
437:
433:
429:
425:
421:
417:
405:
398:
393:
376:
370:
363:
361:
358:
357:
333:
330:
326:
325:
320:
311:
307:
300:
286:
282:
275:
267:
263:
259:
258:
256:
246:
242:
241:
234:
230:
229:
227:
225:
222:
221:
214:
210:
209:
207:
201:
197:
196:
189:
185:
184:
182:
180:
177:
176:
169:
165:
164:
162:
159:
155:
154:
147:
143:
142:
140:
138:
135:
134:
127:
126:ChEMBL1879463
123:
122:
120:
118:
115:
114:
107:
103:
102:
100:
96:
91:
90:
83:
79:
78:
76:
73:
69:
68:
63:
55:
47:
43:
38:
34:
29:
25:
20:
2620:expanding it
2602:
2587:
2486:Tazemetostat
2450:Alitretinoin
2443:
2354:Estramustine
2334:Elsamitrucin
2324:Eflornithine
2278:Pegaspargase
2274:Asparaginase
2267:
2236:Testolactone
2229:
2217:
2205:
2159:
2144:Panobinostat
2127:
2097:
2085:
2073:
2061:
2032:
1997:
1985:
1938:
1934:Padeliporfin
1873:Dactinomycin
1869:Streptomyces
1850:Temozolomide
1845:Mitozolomide
1833:
1824:Mitobronitol
1813:Procarbazine
1806:
1794:Nonclassical
1719:
1696:
1690:Streptozocin
1655:Nitrosoureas
1653:
1627:Chlorambucil
1621:Trofosfamide
1607:Chlormethine
1602:Bendamustine
1595:
1533:Mitoxantrone
1528:Losoxantrone
1521:
1481:Daunorubicin
1464:
1430:
1367:Camptothecin
1355:
1311:
1281:
1267:
1250:
1234:Fluorouracil
1214:Capecitabine
1207:
1177:
1141:
1127:
1097:
1092:Pralatrexate
1082:Methotrexate
1070:
1013:
976:
933:
820:
814:
801:
789:. Retrieved
779:
767:. Retrieved
757:
722:
718:
708:
697:
686:
674:. Retrieved
664:
629:
625:
615:
590:
586:
580:
547:
543:
537:
502:
498:
488:
468:
461:
454:
451:
444:
427:
423:
419:
415:
414:
65:Identifiers
57:Other names
2561:from market
2531:Vorasidenib
2511:Trabectedin
2496:Tiazofurine
2491:Tebentafusp
2476:Tagraxofusp
2434:Plitidepsin
2404:Mitoguazone
2344:Epacadostat
2314:Demecolcine
2258:Aflibercept
2231:Sex steroid
2104:Fuzuloparib
2045:Carfilzomib
2017:Palbociclib
2007:Abemaciclib
1960:Verteporfin
1924:Efaproxiral
1840:Dacarbazine
1802:Altretamine
1784:Satraplatin
1779:Oxaliplatin
1759:Carboplatin
1736:Triaziquone
1707:Mannosulfan
1685:Ranimustine
1665:Fotemustine
1506:Pirarubicin
1491:Doxorubicin
1485:+cytarabine
1471:Aclarubicin
1432:Podophyllum
1357:Camptotheca
1288:Azacitidine
1274:Gemcitabine
1229:Floxuridine
1162:Fludarabine
1157:Clofarabine
1143:Halogenated
1134:Pentostatin
1109:Raltitrexed
1077:Aminopterin
1020:Ixabepilone
1015:Epothilones
983:Cabazitaxel
960:Vinorelbine
945:Vincristine
940:Vinblastine
925:microtubule
418:(codenamed
322:Properties
82:915019-65-7
17:Dactolisib
2680:Quinolines
2659:Categories
2526:Verdinexor
2521:Venetoclax
2424:Oblimersen
2419:Navitoclax
2394:Lucanthone
2389:Lonidamine
2379:Lifileucel
2374:Ivosidenib
2369:Imetelstat
2339:Enasidenib
2329:Elesclomol
2294:Bexarotene
2289:Belzutifan
2224:Bexarotene
2212:Atrasentan
2187:Umbralisib
2182:Idelalisib
2172:Copanlisib
2154:Vorinostat
2149:Romidepsin
2139:Entinostat
2134:Belinostat
2092:Masoprocol
2080:Tiazofurin
2068:Anagrelide
2040:Bortezomib
2027:Seliciclib
2022:Ribociclib
2002:inhibitors
1992:Tipifarnib
1955:Temoporfin
1950:Talaporfin
1888:Plicamycin
1883:Mitomycins
1829:Pipobroman
1808:Hydrazines
1774:Nedaplatin
1726:Carboquone
1721:Aziridines
1712:Treosulfan
1660:Carmustine
1647:Uramustine
1616:Ifosfamide
1588:Alkylating
1549:Bisantrene
1538:Pixantrone
1511:Valrubicin
1501:Idarubicin
1496:Epirubicin
1442:Teniposide
1397:Lurtotecan
1392:Irinotecan
1293:Decitabine
1257:Cytarabine
1200:Pyrimidine
1189:Tioguanine
1179:Thiopurine
1168:Nelarabine
1152:Cladribine
1104:Pemetrexed
1087:Pemetrexed
1063:Folic acid
1003:Paclitaxel
955:Vinflunine
626:Oncotarget
481:References
475:everolimus
420:NVP-BEZ235
416:Dactolisib
360:Molar mass
233:RUJ6Z9Y0DT
158:IUPHAR/BPS
137:ChemSpider
93:3D model (
72:CAS Number
2571:Phase III
2559:Withdrawn
2536:Vosaroxin
2516:Veliparib
2471:Sotorasib
2461:Selinexor
2455:Tretinoin
2445:Retinoids
2359:Glasdegib
2304:Celecoxib
2253:Adagrasib
2177:Duvelisib
2167:Alpelisib
2122:Rucaparib
2109:Niraparib
2050:Oprozomib
2012:Alvocidib
1878:Bleomycin
1835:Triazenes
1819:Etoglucid
1764:Cisplatin
1680:Nimustine
1674:Semustine
1670:Lomustine
1632:Melphalan
1559:Menogaril
1554:Crisnatol
1544:Amsacrine
1516:Zorubicin
1476:Amrubicin
1437:Etoposide
1412:Topotecan
1407:Silatecan
1402:Rubitecan
1387:Gimatecan
1372:Cositecan
1362:Belotecan
1038:inhibitor
1008:Tesetaxel
998:Ortataxel
993:Larotaxel
988:Docetaxel
950:Vindesine
2409:Mitotane
2349:Eribulin
2117:Olaparib
2055:Ixazomib
1731:Thiotepa
1703:Busulfan
1382:Exatecan
1219:Carmofur
927:assembly
890: /
847:32229705
809:(2020).
769:29 March
749:27566248
656:21317453
607:19143644
572:23005922
564:22020918
529:19671762
471:phase 2a
430:) is an
213:11977753
146:10151099
1338:S phase
1239:Tegafur
1053:S phase
978:Taxanes
914:M phase
838:7202545
791:29 July
740:5016067
676:16 July
647:3248138
520:2752877
449:cells.
424:BEZ-235
397:what is
395: (
365:469.548
200:PubChem
2554:WHO-EM
2163:(Pi3K)
1120:Purine
923:Block
845:
835:
747:
737:
654:
644:
605:
570:
562:
527:
517:
428:RTB101
392:verify
389:
306:SMILES
188:D10552
117:ChEMBL
40:Names
2603:This
2075:IMPDI
1970:Other
816:Aging
568:S2CID
281:InChI
95:JSmol
2616:stub
2612:drug
2161:PIKI
2129:HDAC
1578:CCNS
843:PMID
793:2020
771:2017
745:PMID
678:2016
652:PMID
603:PMID
560:PMID
525:PMID
440:mTOR
422:and
224:UNII
179:KEGG
168:7950
2607:or
2207:ERA
2063:PhI
2034:PrI
1999:CDK
1911:PDT
909:MIs
905:SPs
896:L01
833:PMC
825:doi
735:PMC
727:doi
642:PMC
634:doi
595:doi
552:doi
548:113
515:PMC
507:doi
250:EPA
203:CID
2661::
2567::
2087:LI
1987:FI
1453:II
1423:II
1245:))
841:.
831:.
821:12
819:.
813:.
743:.
733:.
723:21
721:.
717:.
650:.
640:.
628:.
624:.
601:.
591:37
589:.
566:.
558:.
546:.
523:.
513:.
501:.
497:.
469:A
344:23
338:30
2647:e
2640:t
2633:v
2622:.
2457:)
2448:(
2280:)
2276:/
2272:(
2238:)
2234:(
2226:)
2222:(
2214:)
2210:(
2189:)
2165:(
2156:)
2132:(
2124:)
2102:(
2094:)
2090:(
2082:)
2078:(
2070:)
2066:(
2029:)
2005:(
1994:)
1990:(
1962:)
1943:(
1909:/
1890:)
1871:(
1852:)
1838:(
1815:)
1811:(
1723::
1714:)
1705:(
1700::
1676:)
1672:(
1657::
1638:)
1634:(
1623:)
1614:(
1599::
1580:)
1576:(
1540:)
1526:(
1518:)
1487:)
1483:(
1469:(
1455:+
1444:)
1435:(
1414:)
1360:(
1348:I
1340:)
1336:(
1320:)
1316:(
1295:)
1286:(
1276:)
1272:(
1262:)
1255:(
1241:(
1212:(
1191:)
1182:(
1164:)
1150:(
1145:/
1136:)
1132:(
1111:)
1102:(
1094:)
1075:(
1055:)
1051:(
1022:)
1018:(
1010:)
981:(
962:)
938:(
916:)
912:(
907:/
898:)
894:(
879:e
872:t
865:v
849:.
827::
795:.
773:.
751:.
729::
680:.
658:.
636::
630:1
609:.
597::
574:.
554::
531:.
509::
503:8
387:N
353:O
350:5
347:N
341:H
335:C
252:)
248:(
97:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
