305:; Godin, R; Leichman, L P. A Phase lb Studying Combining Irinotecan With AZD1775, A Selective WEE 1 Kinase Inhibitor, in RAS/RAF Mutated Metastatic Colorectal Cancer Patients Who Progressed on First Line Therapy .
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In 1995, Bar-Sagi became faculty at the department of molecular genetics and microbiology at State
University of New York (SUNY) at Stony Brook and served as the department chair from 2003 to 2006.
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in 2006 as chair of the department of biochemistry. She became vice dean for science and chief scientific officer at NYU Langone Health in 2011. She became executive vice president in 2019.
101:. She is the Saul J. Farber Professor in the department of biochemistry and molecular pharmacology and the department of medicine and senior vice president and vice dean for science at
365:
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG,
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cancer cells, and understanding how they withstand targeted therapies, as well as identification of novel therapeutic strategies for Ras-driven cancers. Her research on
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suggests that to fully understand the interactions between tumors, their environment, and immune system, researchers will have to find new methods of studying tumors
1180:
317:
Fehrenbacher, Nicole; Tojal da Silva, Israel; Ramirez, Craig; Zhou, Yong; Cho, Kwang-Jin; Kuchay, Shafi; Shi, Jie; Thomas, Susan; Pagano, Michele; Hancock, John F;
269:
Aiello, Nicole M; Maddipati, Ravikanth; Norgard, Robert J; Balli, David; Li, Jinyang; Yuan, Salina; Yamazoe, Taiji; Black, Taylor; Sahmoud, Amine; Furth, Emma E;
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289:. Crosstalk Between Regulatory T Cells and Tumor-Associated Dentritic Cells Negates Anti-Tumor Immunity in Pancreatic Cancer.
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and mutant Ras proteins in cell proliferation, survival, nutrient uptake, cell metabolism and tumorigenesis, particularly in
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183:. Bar-Sagi and Feramisco were the first to observe how Ras protein facilitates cellular uptake of nutrients through
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710:"How pancreatic RAS tumors protect themselves. Researchers point to a new protein — and maybe a new treatment"
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Dafna Bar-Sagi's research began in 1986, while completing her postdoctoral work with Dr. James
Feramisco in
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257:. Pre-Neoplastic Pancreas Cells Enter a Partially Mesenchymal State Following Transient TGF-î² Exposure.
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786:"Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins"
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321:; Philips, Mark R. The G Proteined-Coupled Receptors GPR31 Promotes Membrane Association of KRAS.
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1061:"AACR to Honor Individuals With Scientific Achievement Awards, Lectures During Annual Meeting"
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385:. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia.
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273:; Stanger, Ben Z. EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration.
962:"Coping mechanism suggests new way to make cancer cells more vulnerable to chemotherapies"
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547:"National Institutes of Health, National Cancer Institute, Board of Scientific Advisors"
337:. Macropinocytosis of Nab-Paclitaxel Drives Macrophage Activation in Pancreatic Cancer.
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871:
759:
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Jang, Jung-Eun; Hajdu, Cristina H; Liot, Caroline; Miller, George; Dustin, Michael L;
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and how Ras signaling leads to tumor development, particularly in pancreatic cancer.
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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
153:
Dafna Bar-Sagi conducted her postdoctoral research in the lab of James
Feramisco in
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Cullis, Jane E; Siolas, Despina; Avanzi, Antonina; Barui, Sugata; Maitra, Anirban;
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138:
113:
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184:
937:"2014 Grant Recipient Daphna Bar-Sagi, PhD – Pancreatic Cancer Action Network/"
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2018, AACR-Women in Cancer
Research Charlotte Friend Memorial Lectureship, AACR
1036:"AACR-Women in Cancer Research Charlotte Friend Lectureship: Past Recipients"
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888:
817:
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198:. Recent studies in the Bar-Sagi lab have focused on the treatment of mutant
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915:
785:
825:
600:"Scientific and Medical Advisory Board - Pancreatic Cancer Action Network"
105:. Bar-Sagi has been a member of scientific advisory boards, including the
353:. Stress Granules in Pancreatic Cancer: Drug & Resistance Treatment.
191:
872:"Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer"
208:
443:
Pancreatic Cancer Action
Network Scientific and Medical Advisory Board
141:. She received her PhD in neurobiology in the United States from the
130:
94:
33:
870:
Recouvreux, Maria
Victoria; Commisso, Cosimo (29 September 2017).
437:
National Cancer
Institute Board of Scientific Advisors, Chair 2021
109:, Starr Cancer Consortium, and Pancreatic Cancer Action Network.
432:
Membership on
Scientific Advisory Boards and Boards of Directors
253:
Handler, Jesse; Cullis, Jane; Avanzi, Antonina; Vucic, Emily A;
199:
161:
in 1986, and eventually served as senior staff investigator.
680:"Three NYU Faculty Elected to National Academy of Sciences"
137:
where she earned her undergraduate and master's degrees in
427:
2008, Pancreatic Cancer Action
Network Grant Recipient
424:
2014, Pancreatic Cancer Action
Network Grant Recipient
784:Bar-Sagi, D.; Feramisco, J. R. (5 September 1986).
76:
61:
40:
28:
21:
987:"National Academy of Sciences Elects New Members"
190:Bar-Sagi continues to study the function of Ras
1115:American Association for Cancer Research (AACR)
1086:"NCI Outstanding Investigator Award Recipients"
1040:American Association for Cancer Research (AACR)
1016:American Association for Cancer Research (AACR)
659:American Association for Cancer Research (AACR)
440:Starr Cancer Consortium Scientific Review Board
1012:"Fellows of the AACR Academy: Class Year 2019"
381:Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G,
8:
243:Cold Spring Harbor Perspectives In Medicine.
143:State University of New York at Stony Brook
45:State University of New York at Stony Brook
241:. Kras and Tumor Immunity: Friend or Foe?
112:Her research focuses on the nature of the
18:
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409:American Association for Cancer Research
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157:, where she worked on the nature of the
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1181:21st-century American women scientists
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417:2016, Outstanding Investigator Award,
129:Dafna Bar-Sagi was born and raised in
99:New York University School of Medicine
66:New York University School of Medicine
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1111:"Board of Directors | AACR About Us"
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476:"A Conversation with Dafna Bar-Sagi"
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421:for cancer research in RAS mutations
16:Cell biologist and cancer researcher
960:Brooks, Megan (December 15, 2016).
446:AACR Board of Directors, 2016-2019
14:
941:Pancreatic Cancer Action Network
739:Pancreatic Cancer Action Network
604:Pancreatic Cancer Action Network
847:"the definition of pinocytosis"
373:. 2013 May 30;497(7451):633-7.
708:Mast, Jason (9 January 2020).
325:2017 Jun 15; 216(8):2329-2338
277:2018 Jun 18; 45(6):681-695.e4
261:2018 Aug 02; 37(31):4334-4342
1:
966:ScienceDaily / Reuters Health
389:. 2012 Jun 12;21(6): 836–47.
307:Journal Of Clinical Oncology.
155:Cold Spring Harbor Laboratory
991:National Academy of Sciences
631:National Academy of Sciences
403:National Academy of Sciences
1176:Fellows of the AACR Academy
339:Cancer Immunology Research.
293:2017 Jul 18; 20(3):558-571
237:Cullis, Jane; Das, Shipra;
1197:
1166:American women biochemists
1146:Bar-Ilan University alumni
876:Frontiers in Endocrinology
714:Pershing Square Foundation
341:2017 Jan 20; 5(3):182-190
169:NYU Langone Medical Center
1090:National Cancer Institute
573:"Scientific Review Board"
480:National Cancer Institute
419:National Cancer Institute
301:Cohen, D J; Grabocka, E;
167:Bar-Sagi transitioned to
107:National Cancer Institute
84:
54:
889:10.3389/fendo.2017.00261
323:Journal Of Cell Biology.
93:is a cell biologist and
1156:Jewish women scientists
810:10.1126/science.3090687
764:New York Genome Center
760:"Dafna Bar-Sagi, PhD"
735:"Dafna Bar-Sagi, PhD"
655:"Dafna Bar-Sagi, PhD"
309:2017 Jun 20; (2017):
216:Selected publications
1171:American biochemists
221:Recent Publications
802:1986Sci...233.1061B
796:(4768): 1061–1068.
684:New York University
577:www.starrcancer.org
275:Developmental Cell.
245:2018 Sep 04; 8(9):
222:
135:Bar-Ilan University
49:Bar-Ilan University
1161:Cancer researchers
851:www.dictionary.com
357:2017; 39(4):30-34
220:
181:Cold Spring Harbor
103:NYU Langone Health
70:NYU Langone Health
1151:Jewish scientists
1065:Targeted Oncology
396:Awards and honors
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196:pancreatic cancer
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77:Academic advisors
56:Scientific career
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185:macropinocytosis
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355:Oncology Times.
351:Bar-Sagi, Dafna
335:Bar-Sagi, Dafna
319:Bar-Sagi, Dafna
287:Bar-Sagi, Dafna
271:Bar-Sagi, Dafna
255:Bar-Sagi, Dafna
239:Bar-Sagi, Dafna
218:
177:
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133:. She attended
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80:James Feramisco
41:Alma mater
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204:interleukin-1β
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97:researcher at
91:Dafna Bar-Sagi
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23:Dafna Bar-Sagi
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686:. May 4, 2020
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1092:. 2015-10-14
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159:Ras proteins
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139:neurobiology
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114:Ras oncogene
111:
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62:Institutions
55:
524:med.nyu.edu
387:Cancer Cell
367:Bar-Sagi D.
303:Bar-Sagi, D
1135:Categories
1120:2020-05-02
1096:2018-10-06
1021:2020-05-02
997:2020-05-02
946:2018-10-06
856:2018-10-07
609:2020-05-02
582:2020-05-02
555:2022-04-28
529:2018-10-07
486:2018-10-06
451:References
383:Bar-Sagi D
120:Early life
898:1664-2392
818:0036-8075
259:Oncogene.
229:Citation
192:oncogenes
125:Education
1070:28 April
1045:28 April
971:28 April
916:29085336
831:28 April
769:28 April
744:28 April
719:28 April
690:28 April
664:28 April
636:28 April
175:Research
145:(SUNY).
907:5649207
882:: 261.
826:3090687
798:Bibcode
790:Science
209:in vivo
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896:
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411:(AACR)
371:Nature
149:Career
131:Israel
95:cancer
34:Israel
550:(PDF)
378:2012
362:2013
346:2017
330:2017
314:2017
298:2017
282:2017
266:2018
250:2018
234:2018
226:Year
1072:2022
1047:2022
973:2022
912:PMID
894:ISSN
833:2022
822:PMID
814:ISSN
771:2022
746:2022
721:2022
692:2022
666:2022
638:2022
200:KRAS
29:Born
902:PMC
884:doi
806:doi
794:233
68:,
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1038:.
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