331:
29:
1659:
581:
Douketis J, Cook D, Meade M, et al. (2008). "Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin".
154:
643:
109:
627:
479:
51:
540:
The PROTECT Investigators for the
Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2011).
1499:
737:
829:
644:"FDA approves first anticoagulant (blood thinner) for pediatric patients to treat potentially life-threatening blood clots, PM FDA, May 16, 2019"
1613:
408:
1684:
407:
approved
Fragmin injection to reduce the recurrence of symptomatic VTE in pediatric patients one month of age and older. It is on the
984:
780:
1594:
1002:
975:
715:
501:"Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer"
139:
929:
460:
730:
624:
476:
1213:
649:
404:
343:
279:
1630:
1304:
1024:
1649:
1386:
1360:
1352:
672:
496:
1689:
723:
389:
1618:
95:
326:
967:
891:
382:
374:
102:
1495:
1557:
1136:
1091:
351:
195:
947:
704:
223:
1238:
606:
400:
is reduced. Approximately 70% of dalteparin is excreted through kidneys based on animal studies.
355:
69:
358:
to reduce the risk of a stroke or heart attack. Dalteparin acts by potentiating the activity of
28:
1400:
803:
798:
350:. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of
1679:
1482:
1253:
1243:
1233:
1223:
1198:
771:
758:
750:
598:
563:
522:
167:
41:
1456:
1287:
1248:
1218:
680:
590:
553:
512:
359:
177:
288:
1663:
1260:
631:
483:
464:
397:
232:
185:
330:
61:
1624:
1151:
837:
746:
625:
https://www.pfizermedicalinformation.ca/en-ca/fragmin/action-and-clinical-pharmacology#
477:
https://www.pfizermedicalinformation.ca/en-ca/fragmin/action-and-clinical-pharmacology#
1673:
1581:
1551:
1141:
1126:
1121:
1082:
754:
373:
The CLOT study, published in 2003, showed that in patients with malignancy and acute
319:
1571:
1541:
1519:
1514:
1487:
1436:
1415:
1265:
1204:
1160:
1037:
980:
919:
914:
895:
793:
762:
610:
122:
117:
457:
431:
20:
594:
1441:
1369:
1338:
1270:
1171:
1165:
1155:
1058:
852:
842:
381:
in reducing the risk of recurrent embolic events. Dalteparin is not superior to
1546:
1463:
1446:
1431:
1410:
1395:
1390:
1333:
1318:
1292:
1282:
1277:
1131:
1100:
1032:
1012:
990:
879:
863:
859:
808:
263:
677:
World Health
Organization model list of essential medicines: 22nd list (2021)
1534:
1529:
1509:
1504:
1451:
1405:
1379:
1374:
1323:
1181:
1104:
1068:
1042:
1007:
995:
957:
952:
942:
904:
874:
869:
847:
813:
788:
363:
208:
55:
602:
567:
526:
558:
541:
1328:
1313:
1146:
1117:
1108:
1096:
1063:
909:
517:
500:
378:
367:
243:
685:
252:
1599:
1589:
1566:
1364:
1193:
937:
1561:
542:"Dalteparin versus unfractionated heparin in critically ill patients"
499:, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003).
396:, but studies have shown that dalteparin does not accumulate even if
393:
308:
823:
1468:
299:
719:
161:
148:
80:
623:
Pfizer
Medication Information: Fragmin Pharmacokinetics |
475:
Pfizer
Medical Information: Fragmin Pharmacodynamics |
409:
1647:
426:
424:
456:
Dalteparin - Subcutaneous
Injection, HealthLinkBC |
1580:
1481:
1424:
1351:
1303:
1192:
1180:
1090:
1081:
1051:
1023:
966:
928:
890:
822:
779:
770:
318:
298:
278:
262:
242:
222:
217:
207:
194:
184:
176:
138:
133:
108:
94:
68:
50:
40:
35:
370:. It is normally administered by self-injection.
458:https://www.healthlinkbc.ca/medications/fdb0271
231:
731:
8:
19:
432:"Dalteparin (Fragmin) Use During Pregnancy"
1189:
1087:
776:
738:
724:
716:
329:
27:
684:
557:
516:
287:
203:3-5 hours subcutaneous; 2.1-2.3 hours IV
1654:
495:Lee AY, Levine MN, Baker RI, Bowden C,
420:
405:U.S. Food and Drug Administration (FDA)
251:
320:
18:
679:. Geneva: World Health Organization.
377:, dalteparin was more effective than
60:
7:
711:. U.S. National Library of Medicine.
121:
307:
14:
1657:
1353:Direct thrombin (IIa) inhibitors
781:Glycoprotein IIb/IIIa inhibitors
976:Thromboxane synthase inhibitors
546:New England Journal of Medicine
362:, inhibiting formation of both
1:
1214:Low-molecular-weight heparin
1025:Phosphodiesterase inhibitors
938:Acetylsalicylic acid/Aspirin
650:Food and Drug Administration
595:10.1001/archinte.168.16.1805
375:venous thromboembolism (VTE)
344:low molecular weight heparin
385:in preventing blood clots.
1706:
689:. WHO/MHP/HPS/EML/2021.02.
1685:Drugs developed by Pfizer
1608:
1186:(with some II inhibition)
673:World Health Organization
26:
709:Drug Information Portal
1496:Plasminogen activators
968:Thromboxane inhibitors
892:Prostaglandin analogue
383:unfractionated heparin
1558:serine endopeptidases
1092:Vitamin K antagonists
559:10.1056/NEJMoa1014475
346:. It is marketed as
1305:Direct Xa inhibitors
1137:Ethyl biscoumacetate
1003:Receptor antagonists
518:10.1056/NEJMoa025313
352:deep vein thrombosis
948:Carbasalate calcium
705:"Dalteparin sodium"
157:(Prescription only)
23:
16:Pharmaceutical drug
1635:Never to phase III
1483:Thrombolytic drugs
1199:glycosaminoglycans
772:Antiplatelet drugs
759:antiplatelet drugs
630:2021-05-07 at the
482:2021-05-07 at the
463:2021-05-03 at the
438:. 27 November 2019
356:pulmonary embolism
1645:
1644:
1477:
1476:
1347:
1346:
1077:
1076:
589:(16): 1805–1812.
552:(14): 1305–1314.
403:In May 2019, the
337:
336:
165:
152:
84:
21:Dalteparin sodium
1697:
1662:
1661:
1660:
1653:
1457:Drotrecogin alfa
1437:Antithrombin III
1288:Dermatan sulfate
1261:Oligosaccharides
1190:
1088:
824:ADP receptor/P2Y
777:
740:
733:
726:
717:
712:
691:
690:
688:
669:
663:
662:
660:
658:
640:
634:
621:
615:
614:
578:
572:
571:
561:
537:
531:
530:
520:
492:
486:
473:
467:
454:
448:
447:
445:
443:
428:
360:antithrombin III
333:
322:
311:
291:
255:
235:
199:
163:
160:
150:
147:
125:
82:
79:
64:
31:
24:
22:
1705:
1704:
1700:
1699:
1698:
1696:
1695:
1694:
1690:Polysaccharides
1670:
1669:
1668:
1658:
1656:
1648:
1646:
1641:
1640:
1625:Clinical trials
1604:
1576:
1486:
1473:
1420:
1343:
1299:
1202:
1197:
1185:
1176:
1152:1,3-Indandiones
1094:
1073:
1047:
1019:
962:
924:
886:
838:Thienopyridines
827:
818:
766:
747:Antithrombotics
744:
703:
700:
695:
694:
671:
670:
666:
656:
654:
642:
641:
637:
632:Wayback Machine
622:
618:
583:Arch Intern Med
580:
579:
575:
539:
538:
534:
494:
493:
489:
484:Wayback Machine
474:
470:
465:Wayback Machine
455:
451:
441:
439:
430:
429:
422:
417:
398:kidney function
314:
294:
274:
258:
238:
197:
186:Bioavailability
178:Pharmacokinetic
172:
129:
97:
90:
71:
17:
12:
11:
5:
1703:
1701:
1693:
1692:
1687:
1682:
1672:
1671:
1667:
1666:
1643:
1642:
1639:
1638:
1637:
1636:
1633:
1622:
1616:
1610:
1609:
1606:
1605:
1603:
1602:
1597:
1592:
1586:
1584:
1578:
1577:
1575:
1574:
1569:
1564:
1554:
1549:
1544:
1539:
1538:
1537:
1532:
1524:
1523:
1522:
1517:
1512:
1507:
1492:
1490:
1479:
1478:
1475:
1474:
1472:
1471:
1466:
1461:
1460:
1459:
1449:
1444:
1439:
1434:
1428:
1426:
1422:
1421:
1419:
1418:
1413:
1408:
1403:
1398:
1393:
1384:
1383:
1382:
1377:
1372:
1357:
1355:
1349:
1348:
1345:
1344:
1342:
1341:
1336:
1331:
1326:
1321:
1316:
1310:
1308:
1301:
1300:
1298:
1297:
1296:
1295:
1290:
1285:
1275:
1274:
1273:
1268:
1258:
1257:
1256:
1251:
1246:
1241:
1236:
1231:
1226:
1221:
1210:
1208:
1187:
1178:
1177:
1175:
1174:
1168:
1163:
1158:
1149:
1144:
1139:
1134:
1129:
1124:
1114:
1112:
1085:
1083:Anticoagulants
1079:
1078:
1075:
1074:
1072:
1071:
1066:
1061:
1055:
1053:
1049:
1048:
1046:
1045:
1040:
1035:
1029:
1027:
1021:
1020:
1018:
1017:
1016:
1015:
1010:
1000:
999:
998:
993:
988:
972:
970:
964:
963:
961:
960:
955:
950:
945:
940:
934:
932:
930:COX inhibitors
926:
925:
923:
922:
917:
912:
907:
901:
899:
888:
887:
885:
884:
883:
882:
877:
872:
857:
856:
855:
850:
845:
834:
832:
825:
820:
819:
817:
816:
811:
806:
801:
796:
791:
785:
783:
774:
768:
767:
755:anticoagulants
745:
743:
742:
735:
728:
720:
714:
713:
699:
698:External links
696:
693:
692:
664:
635:
616:
573:
532:
487:
468:
449:
419:
418:
416:
413:
335:
334:
324:
316:
315:
313:
312:
304:
302:
296:
295:
293:
292:
284:
282:
276:
275:
273:
272:
268:
266:
260:
259:
257:
256:
248:
246:
240:
239:
237:
236:
228:
226:
220:
219:
215:
214:
211:
205:
204:
201:
192:
191:
188:
182:
181:
174:
173:
171:
170:
158:
144:
142:
136:
135:
131:
130:
128:
127:
114:
112:
106:
105:
100:
98:administration
92:
91:
89:
88:
86:
76:
74:
66:
65:
58:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
1702:
1691:
1688:
1686:
1683:
1681:
1678:
1677:
1675:
1665:
1655:
1651:
1634:
1632:
1629:
1628:
1626:
1623:
1620:
1617:
1615:
1612:
1611:
1607:
1601:
1598:
1596:
1593:
1591:
1588:
1587:
1585:
1583:
1582:Non-medicinal
1579:
1573:
1570:
1568:
1565:
1563:
1559:
1555:
1553:
1552:Streptokinase
1550:
1548:
1545:
1543:
1540:
1536:
1533:
1531:
1528:
1527:
1525:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1502:
1501:
1497:
1494:
1493:
1491:
1489:
1488:fibrinolytics
1484:
1480:
1470:
1467:
1465:
1462:
1458:
1455:
1454:
1453:
1450:
1448:
1445:
1443:
1440:
1438:
1435:
1433:
1430:
1429:
1427:
1423:
1417:
1414:
1412:
1409:
1407:
1404:
1402:
1399:
1397:
1394:
1392:
1388:
1385:
1381:
1378:
1376:
1373:
1371:
1368:
1367:
1366:
1362:
1359:
1358:
1356:
1354:
1350:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1322:
1320:
1317:
1315:
1312:
1311:
1309:
1306:
1302:
1294:
1291:
1289:
1286:
1284:
1281:
1280:
1279:
1276:
1272:
1269:
1267:
1264:
1263:
1262:
1259:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1237:
1235:
1232:
1230:
1227:
1225:
1222:
1220:
1217:
1216:
1215:
1212:
1211:
1209:
1206:
1200:
1195:
1191:
1188:
1183:
1179:
1173:
1169:
1167:
1164:
1162:
1159:
1157:
1153:
1150:
1148:
1145:
1143:
1142:Phenprocoumon
1140:
1138:
1135:
1133:
1130:
1128:
1127:Coumatetralyl
1125:
1123:
1122:Acenocoumarol
1119:
1116:
1115:
1113:
1110:
1106:
1102:
1098:
1093:
1089:
1086:
1084:
1080:
1070:
1067:
1065:
1062:
1060:
1057:
1056:
1054:
1050:
1044:
1041:
1039:
1036:
1034:
1031:
1030:
1028:
1026:
1022:
1014:
1011:
1009:
1006:
1005:
1004:
1001:
997:
994:
992:
989:
986:
982:
979:
978:
977:
974:
973:
971:
969:
965:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
935:
933:
931:
927:
921:
918:
916:
913:
911:
908:
906:
903:
902:
900:
897:
893:
889:
881:
878:
876:
873:
871:
868:
867:
865:
861:
858:
854:
851:
849:
846:
844:
841:
840:
839:
836:
835:
833:
831:
828:
821:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
786:
784:
782:
778:
775:
773:
769:
764:
760:
756:
752:
751:thrombolytics
748:
741:
736:
734:
729:
727:
722:
721:
718:
710:
706:
702:
701:
697:
687:
682:
678:
674:
668:
665:
653:
651:
645:
639:
636:
633:
629:
626:
620:
617:
612:
608:
604:
600:
596:
592:
588:
584:
577:
574:
569:
565:
560:
555:
551:
547:
543:
536:
533:
528:
524:
519:
514:
511:(2): 146–53.
510:
506:
502:
498:
491:
488:
485:
481:
478:
472:
469:
466:
462:
459:
453:
450:
437:
433:
427:
425:
421:
414:
412:
410:
406:
401:
399:
395:
391:
388:Heparins are
386:
384:
380:
376:
371:
369:
365:
361:
357:
353:
349:
345:
341:
332:
328:
325:
323:
321:ECHA InfoCard
317:
310:
306:
305:
303:
301:
297:
290:
286:
285:
283:
281:
277:
270:
269:
267:
265:
261:
254:
250:
249:
247:
245:
241:
234:
230:
229:
227:
225:
221:
216:
212:
210:
206:
202:
200:
193:
189:
187:
183:
179:
175:
169:
159:
156:
146:
145:
143:
141:
137:
132:
124:
119:
116:
115:
113:
111:
107:
104:
101:
99:
93:
87:
78:
77:
75:
73:
67:
63:
59:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
1572:Fibrinolysin
1542:Anistreplase
1520:Desmoteplase
1515:Tenecteplase
1416:Ximelagatran
1266:Fondaparinux
1228:
1205:antithrombin
1161:Diphenadione
1038:Dipyridamole
981:Dipyridamole
920:Treprostinil
915:Prostacyclin
794:Eptifibatide
708:
686:10665/345533
676:
667:
655:. Retrieved
647:
638:
619:
586:
582:
576:
549:
545:
535:
508:
505:N Engl J Med
504:
490:
471:
452:
440:. Retrieved
435:
402:
387:
372:
347:
339:
338:
196:Elimination
140:Legal status
134:Legal status
103:Subcutaneous
1621:from market
1442:Defibrotide
1370:Bivalirudin
1339:Rivaroxaban
1278:Heparinoids
1271:Idraparinux
1172:Tioclomarol
1166:Phenindione
1156:Clorindione
1059:Cloricromen
853:Ticlopidine
843:Clopidogrel
327:100.110.590
218:Identifiers
42:Trade names
1674:Categories
1547:Monteplase
1464:Ramatroban
1447:Nafamostat
1432:Abelacimab
1411:Melagatran
1396:Dabigatran
1391:Argatroban
1334:Otamixaban
1319:Betrixaban
1307:("xabans")
1293:Sulodexide
1283:Danaparoid
1254:Tinzaparin
1244:Parnaparin
1239:Nadroparin
1234:Enoxaparin
1229:Dalteparin
1224:Certoparin
1184:inhibitors
1132:Dicoumarol
1033:Cilostazol
1013:Terutroban
991:Picotamide
880:Ticagrelor
864:nucleoside
860:Nucleotide
830:inhibitors
809:Sibrafiban
415:References
340:Dalteparin
289:12M44VTJ7B
264:ChemSpider
224:CAS Number
1631:Phase III
1619:Withdrawn
1535:Urokinase
1530:Saruplase
1510:Reteplase
1505:Alteplase
1452:Protein C
1406:Inogatran
1401:Efegatran
1387:Univalent
1380:Lepirudin
1375:Desirudin
1324:Darexaban
1249:Reviparin
1219:Bemiparin
1182:Factor Xa
1118:Coumarins
1095:(inhibit
1069:Vorapaxar
1043:Triflusal
1008:Terbogrel
996:Terbogrel
985:+ aspirin
958:Triflusal
953:Indobufen
943:Aloxiprin
905:Beraprost
875:Elinogrel
870:Cangrelor
848:Prasugrel
814:Tirofiban
804:Roxifiban
799:Orbofiban
789:Abciximab
497:Kakkar AK
436:Drugs.com
364:Factor Xa
233:9041-08-1
209:Excretion
198:half-life
96:Routes of
70:Pregnancy
62:Monograph
56:Drugs.com
1680:Heparins
1664:Medicine
1361:Bivalent
1329:Edoxaban
1314:Apixaban
1147:Warfarin
1064:Ditazole
910:Iloprost
866:analogs
675:(2021).
628:Archived
603:18779469
568:21417952
527:12853587
480:Archived
461:Archived
379:warfarin
368:thrombin
244:DrugBank
110:ATC code
72:category
1600:Oxalate
1590:Citrate
1567:Brinase
1365:Hirudin
1194:Heparin
1170:Other:
611:1513885
394:kidneys
392:by the
390:cleared
348:Fragmin
253:DB06779
126:)
120: (
118:B01AB04
85: C
46:Fragmin
1650:Portal
1614:WHO-EM
1562:Ancrod
1556:Other
1203:(bind
1196:group/
657:17 May
609:
601:
566:
525:
442:1 June
309:D03353
213:Kidney
190:81-93%
168:℞-only
166:
153:
1500:r-tPA
1425:Other
1052:Other
652:(FDA)
648:U.S.
607:S2CID
342:is a
1595:EDTA
1526:UPA
1469:REG1
896:PGI2
757:and
659:2019
599:PMID
564:PMID
523:PMID
444:2020
366:and
354:and
300:KEGG
280:UNII
271:none
180:data
52:AHFS
1101:VII
763:B01
761:) (
681:hdl
591:doi
587:168
554:doi
550:364
513:doi
509:349
123:WHO
1676::
1627::
1560::
1498::
1389::
1363::
1154::
1120::
1107:,
1105:IX
1103:,
1099:,
1097:II
826:12
753:,
707:.
646:.
605:.
597:.
585:.
562:.
548:.
544:.
521:.
507:.
503:.
434:.
423:^
411:.
162:US
155:S4
149:AU
81:AU
1652::
1485:/
1207:)
1201:/
1111:)
1109:X
987:)
983:(
898:)
894:(
862:/
765:)
749:(
739:e
732:t
725:v
683::
661:.
613:.
593::
570:.
556::
529:.
515::
446:.
164::
151::
83::
54:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
