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Daniela M. Ferreira

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Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage. Am J Respir Crit Care Med. 2016
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Mitsi. E, Carniel.B, Reiné.J, Rylance.J, Zaidi. S, Soares-Schanos.A, Connor. V, Collins. A, Schlitzer. A, Nikolaou. E, SolorzanoGonzalez. C, Pojar. S , Hill. H, Hyder-Wright. A, Jambo. K , Oggioni. M. De Ste Croix, Megan, Gordon.S, Jochems.S, and Ferreira. DM. Nasal Pneumococcal Density is Associated
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Adler H, German EL, Mitsi E, Nikolaou E, Pojar S, Hales C, Robinson R, Connor V, Hill H, Hyder-Wright AD, Lazarova L, Lowe C, Smith EL, Wheeler I, Zaidi SR, Jochems SP, Loukov D, Reiné J, Solórzano-Gonzalez C, de Gorguette d'Argoeuves P, Jones T, Goldblatt D, Chen T, Aston SJ, French N, Collins AM,
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Jochems SP, Marcon F, Carniel BF, Zaidi S, Piddock K, Wheeler I, Gordon SB, Rylance J, Nakaya H, Ferreira DM. Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage. Nature Immunology. 2018 Dec;19(12):1299-1308. doi: 10.1038/s41590-018-0231-y. Epub 2018 Oct
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Jochems S, K.de Ruiter, C.Solórzano, A. Voskamp, E.Mitsi, E.Nikolaou, B.Carniel, S. Pojar, E.German, J. Reiné, A. Soares-Schanoski, H. Hill, R.Robinson, A. Hyder-Wright, C. M. Weight, P.F. Durrenberger, R.S. Heyderman, S. B. Gordon, H. H. Smits, B.C. Urban, J. Rylance, A.. Collins, M. D. Wilkie,
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Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Moreno LB, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB. Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in
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Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM, Gordon SB, Ferreira DM. Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage. Mucosal
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E Mitsi, AM Roche, J Reiné, T Zangari, JT Owugha1, SH Pennington, JF Gritzfeld, AM Collins, S van Selm, MI de Jonge, SB Gordon, JN Weiser, DM Ferreira. Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage. Mucosal
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De Steenhuijsen Piters, Wouter A. A.; Jochems, Simon P.; Mitsi, Elena; Rylance, Jamie; Pojar, Sherin; Nikolaou, Elissavet; German, Esther L.; Holloway, Mark; Carniel, Beatriz F.; Chu, Mei Ling J. N.; Arp, Kayleigh; Sanders, Elisabeth A. M.; Ferreira, Daniela M.; Bogaert, Debby (2019).
87: 231:. She leads a team of scientists studying protective immune responses against pneumococcus and other respiratory pathogens such as SARS-CoV2. Her team has established a novel method of inducing pneumococcal carriage in human volunteers. They use this model to: 367:
Rylance J, de Steenhuijsen Piters WAA, Mina MJ, Bogaert D, French N, Ferreira DM; and the EHPC-LAIV study group. Two Randomized Trials of Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization. Am J Respir Crit Care Med. 2019 Feb 13. doi:
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Gordon SB, J*Rylance Ferreira DM*. Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic. Am J Respir Crit Care Med. 2021 Mar 1;203(5):604-613. doi: 10.1164/rccm.202004-1483OC. PMID 32941735; PMCID: PMC7924584.
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led the development of an Experimental Human Pneumococcal Nasopharyngeal Colonization Model. Ferreira was appointed Professor and subsequent Head of Department of Clinical Sciences in 2018. Her main lines of research are:
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L.Lazarova, S.C. Leong, M.Yazdanbakhsh, Ferreira DM. Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization, J Clin Invest. 2019, Oct;129(10):4523-4538.
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Ferreira is part of the HIC-VAC consortium and Leads the WorkStream on Human Challenge Plataform to accelerate product development in the UKRI Infection Innovation Consortium (iiCON).
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Steenhuijsen Piters WAA, Jochems S, Mitsi E, Rylance J, Pojar S, Nikolaou E, German EL, Holloway M, Carniel BF, Chu MLJN, Arp K,. Sanders EAM, Ferreira DM* and
191: 711:"Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens" 288: 236: 228: 174: 1126:"Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults" 356:* Interaction between live-attenuated influenza vaccine, Streptococcus pneumoniae and the nasal microbiota. Nat Commun. 10, 2981 (2019), 341:
with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. Am J Respir Crit Care Med. Oct 2019.
455: 1024:"Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage" 634:"Pneumococcus Human Infection Challenge and the Effect of Respiratory Virus Co-infections on Mucosal Immunity – Prof Daniela Ferreira" 192:
DNA vaccines against Streptococcus pneumoniae based on PspA (Pneumococcal surface protein A) and PspC (Pneumococcal surface protein C)
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2) Understanding nasal and lung immune responses and correlates of protection against respiratory infection with viruses including
1186: 1075:"Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage" 402: 1191: 152: 277: 126: 121: 814:"Interaction between the nasal microbiota and S. Pneumoniae in the context of live-attenuated influenza vaccine" 296: 973:"Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage" 762:"Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization" 564:"Brasileira que coordena testes com vacina para Covid-19 na Inglaterra explica dilema da prova de eficácia" 1181: 257:
Her team has played a substantial role in the UK covid-19 pandemic response as a trial site for several
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and vaccine responses. She is currently Professor of Respiratory Infection and Vaccinology at the
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3) Defining how respiratory virus co-infections (flu, RSV and SARS-CoV2) and host susceptibility (
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Ferreira obtained a Degree and Bachelor's Degree in Biological Sciences in 2005 and a Ph.D. in
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Research on Respiratory Infections and Covid-19 Vaccine trials
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vaccine studies including the Oxford / Astrazeneca vaccine.
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Healthy Adults. Am J Respir Crit Care Med. 2013 Jan 31.
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and the Director of the Liverpool Vaccine Group at the
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Immunol. 2016 Jan;9(1):56-67. doi: 10.1038/mi.2015.35.
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1) Accelerate development and test novel pneumococcal
490:"Experimental Human Pneumococcal Carriage consortium" 287:Ferreira joined the Respiratory Infection group at 184: 166: 148: 133: 117: 103: 93: 77: 249:Discover how the host alters the biology of the 403:"Connecting immunology in the time of COVID-19" 376:Immunol. 2016 Aug 31. doi: 10.1038/mi.2016.71. 246:candidates and test new vaccines more rapidly 8: 284:Research Award in Pneumococcal Vaccinology. 235:Discover how people with risk factors (age, 358:https://doi.org/10.1038/s41467-019-10814-9 343:https://doi.org/10.1164/rccm.201903-0607OC 85: 74: 1151: 1141: 1100: 1090: 1049: 1039: 998: 988: 947: 937: 896: 886: 845: 787: 777: 736: 726: 685: 675: 484: 482: 480: 478: 476: 295:in December 2009 and together with Prof. 223:in the Department of Paediatrics at the 1197:21st-century Brazilian women scientists 394: 494:Liverpool School of Tropical Medicine 289:Liverpool School of Tropical Medicine 229:Liverpool School of Tropical Medicine 175:Liverpool School of Tropical Medicine 7: 425: 423: 14: 971:Ferreira, Pennington; SH (2016). 23: 869:Ferreira, Jochems; SP (2018). 1: 1124:Gordon, Ferreira; DM (2013). 1073:Ferreira, Glennie; S (2016). 920:Ferreira, Glennie; S (2019). 760:Ferreira, Jochems; S (2019). 431:"Professor Daniela Ferreira" 308:using experimental carriage 1022:Ferreira, Mitsi; E (2017). 709:Ferreira, Mitsi; E (2020). 658:Ferreira, Adler; H (2021). 368:10.1164/rccm.201811-2081LE. 153:Respiratory tract infection 1213: 1143:10.1164/rccm.201212-2277OC 990:10.1164/rccm.201512-2467OC 939:10.1164/rccm.201811-2081LE 838:10.1038/s41467-019-10814-9 728:10.1164/rccm.201903-0607OC 677:10.1164/rccm.202004-1483OC 1130:Am J Respir Crit Care Med 977:Am J Respir Crit Care Med 926:Am J Respir Crit Care Med 888:10.1038/s41590-018-0231-y 715:Am J Respir Crit Care Med 664:Am J Respir Crit Care Med 570:(in Brazilian Portuguese) 372:Dec 15;194(12):1523-1531. 253:while it is being carried 202: 141: 84: 1187:Brazilian immunologists 638:Imperial College London 278:University of São Paulo 276:in 2009, both from the 211:is a Brazilian British 127:University of São Paulo 122:University of São Paulo 38:, as no other articles 16:Brazilian immunologist 1192:Influenza researchers 818:Nature Communications 590:"HIC-VACc onsortium" 237:chronic lung disease 225:University of Oxford 221:Oxford Vaccine Group 171:University of Oxford 830:2019NatCo..10.2981D 544:. 12 September 2021 407:www.eventsforce.net 293:postdoctoral fellow 268:Research and career 209:Daniela M. Ferreira 98:Daniela M. Ferreira 79:Daniela M. Ferreira 1092:10.1038/mi.2015.35 1041:10.1038/mi.2016.71 217:mucosal immunology 179:Butantan institute 57:for suggestions. 47:to this page from 983:(12): 1523–1531. 881:(12): 1299–1308. 875:Nature Immunology 779:10.1172/JCI128865 772:(10): 4523–4538. 206: 205: 143:Scientific career 71: 70: 1204: 1166: 1165: 1155: 1145: 1121: 1115: 1114: 1104: 1094: 1070: 1064: 1063: 1053: 1043: 1019: 1013: 1012: 1002: 992: 968: 962: 961: 951: 941: 932:(9): 1160–1163. 917: 911: 910: 900: 890: 866: 860: 859: 849: 808: 802: 801: 791: 781: 757: 751: 750: 740: 730: 706: 700: 699: 689: 679: 655: 649: 648: 646: 644: 630: 624: 623: 621: 619: 608: 602: 601: 599: 597: 586: 580: 579: 577: 575: 560: 554: 553: 551: 549: 534: 528: 527: 525: 523: 512: 506: 505: 503: 501: 486: 471: 470: 468: 466: 452: 446: 445: 443: 441: 427: 418: 417: 415: 413: 399: 331:Key Publications 198: 89: 75: 66: 63: 52: 50:related articles 27: 19: 1212: 1211: 1207: 1206: 1205: 1203: 1202: 1201: 1172: 1171: 1170: 1169: 1123: 1122: 1118: 1079:Mucosal Immunol 1072: 1071: 1067: 1028:Mucosal Immunol 1021: 1020: 1016: 970: 969: 965: 919: 918: 914: 868: 867: 863: 810: 809: 805: 759: 758: 754: 708: 707: 703: 657: 656: 652: 642: 640: 632: 631: 627: 617: 615: 610: 609: 605: 595: 593: 588: 587: 583: 573: 571: 562: 561: 557: 547: 545: 536: 535: 531: 521: 519: 514: 513: 509: 499: 497: 488: 487: 474: 464: 462: 454: 453: 449: 439: 437: 429: 428: 421: 411: 409: 401: 400: 396: 391: 333: 282:Robert Austrian 270: 196: 177: 173: 125: 99: 80: 67: 61: 58: 48: 45:introduce links 28: 17: 12: 11: 5: 1210: 1208: 1200: 1199: 1194: 1189: 1184: 1174: 1173: 1168: 1167: 1136:(8): 855–864. 1116: 1065: 1034:(2): 385–394. 1014: 963: 912: 861: 803: 752: 721:(3): 335–347. 701: 670:(5): 604–613. 650: 625: 603: 581: 555: 529: 507: 472: 447: 419: 393: 392: 390: 387: 386: 385: 381: 377: 373: 369: 365: 361: 350: 346: 338: 332: 329: 328: 327: 316: 309: 297:Stephen Gordon 269: 266: 255: 254: 247: 240: 204: 203: 200: 199: 188: 182: 181: 168: 164: 163: 150: 146: 145: 139: 138: 135: 134:Known for 131: 130: 119: 115: 114: 105: 101: 100: 97: 95: 91: 90: 82: 81: 78: 69: 68: 55:Find link tool 31: 29: 22: 15: 13: 10: 9: 6: 4: 3: 2: 1209: 1198: 1195: 1193: 1190: 1188: 1185: 1183: 1182:Living people 1180: 1179: 1177: 1163: 1159: 1154: 1149: 1144: 1139: 1135: 1131: 1127: 1120: 1117: 1112: 1108: 1103: 1098: 1093: 1088: 1084: 1080: 1076: 1069: 1066: 1061: 1057: 1052: 1047: 1042: 1037: 1033: 1029: 1025: 1018: 1015: 1010: 1006: 1001: 996: 991: 986: 982: 978: 974: 967: 964: 959: 955: 950: 945: 940: 935: 931: 927: 923: 916: 913: 908: 904: 899: 894: 889: 884: 880: 876: 872: 865: 862: 857: 853: 848: 843: 839: 835: 831: 827: 823: 819: 815: 807: 804: 799: 795: 790: 785: 780: 775: 771: 767: 766:J Clin Invest 763: 756: 753: 748: 744: 739: 734: 729: 724: 720: 716: 712: 705: 702: 697: 693: 688: 683: 678: 673: 669: 665: 661: 654: 651: 639: 635: 629: 626: 613: 607: 604: 591: 585: 582: 569: 565: 559: 556: 543: 539: 533: 530: 517: 511: 508: 495: 491: 485: 483: 481: 479: 477: 473: 461: 457: 451: 448: 436: 432: 426: 424: 420: 408: 404: 398: 395: 388: 382: 378: 374: 370: 366: 362: 359: 355: 351: 347: 344: 339: 335: 334: 330: 325: 321: 317: 315:and bacteria 314: 310: 307: 303: 302: 301: 298: 294: 290: 285: 283: 279: 275: 267: 265: 262: 260: 252: 248: 245: 241: 238: 234: 233: 232: 230: 226: 222: 218: 214: 210: 201: 194: 193: 189: 187: 183: 180: 176: 172: 169: 165: 162: 158: 154: 151: 147: 144: 140: 136: 132: 128: 123: 120: 116: 113: 109: 106: 102: 96: 92: 88: 83: 76: 73: 65: 56: 51: 46: 42: 41: 37: 32:This article 30: 26: 21: 20: 1133: 1129: 1119: 1085:(1): 56–67. 1082: 1078: 1068: 1031: 1027: 1017: 980: 976: 966: 929: 925: 915: 878: 874: 864: 821: 817: 806: 769: 765: 755: 718: 714: 704: 667: 663: 653: 641:. 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Brazilian
British
University of São Paulo
University of São Paulo
Respiratory tract infection
Vaccine
Immunology
University of Oxford
Liverpool School of Tropical Medicine
Butantan institute
Thesis
DNA vaccines against Streptococcus pneumoniae based on PspA (Pneumococcal surface protein A) and PspC (Pneumococcal surface protein C)
immunologist
mucosal immunology
Oxford Vaccine Group
University of Oxford
Liverpool School of Tropical Medicine
chronic lung disease
vaccine
bacteria
COVID-19
Immunology
University of São Paulo

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