31:
1283:
Parks, Derek J.; Blanchard, Steven G.; Bledsoe, Randy K.; Chandra, Gyan; Consler, Thomas G.; Kliewer, Steven A.; Stimmel, Julie B.; Willson, Timothy M.; Zavacki, Ann Marie; Moore, David D.; Lehmann, JĂĽrgen M. (1999-05-21).
412:
In 1996, Moore and his lab identified the small heterodimer partner (SHP), an orphan nuclear receptor without DNA-binding activity which binds other proteins to regulate their activity. He found that SHP inhibits
1642:
Dong, Bingning; Saha, Pradip K.; Huang, Wendong; Chen, Wenling; Abu-Elheiga, Lutfi A.; Wakil, Salih J.; Stevens, Robert D.; Ilkayeva, Olga; Newgard, Christopher B.; Chan, Lawrence; Moore, David D. (2009-11-03).
1827:
278:
Moore has been a leading figure in the investigation of nuclear hormone receptors, having initially discovered and described many family members. Some of his most significant discoveries are the
1837:
1822:
510:
157:
212:
1331:
Forman, Barry M.; Tzameli, Iphigenia; Choi, Hueng-Sik; Chen, Jasmine; Simha, Devendranath; Seol, Wongi; Evans, Ronald M.; Moore, David D. (October 1998).
1226:
Wu, Nan; Kim, Kang Ho; Zhou, Ying; Lee, Jae Man; Kettner, Nicole M.; Mamrosh, Jennifer L.; Choi, Sungwoo; Fu, Loning; Moore, David D. (2016-09-01).
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193:
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1171:"The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression"
1752:
1439:
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Huang, Jiansheng; Iqbal, Jahangir; Saha, Pradip K.; Liu, Jun; Chan, Lawrence; Hussain, M. Mahmood; Moore, David D.; Wang, Li (July 2007).
329:
78:
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Dong, Bingning; Lee, Ju-Seog; Park, Yun-Yong; Yang, Feng; Xu, Ganyu; Huang, Wendong; Finegold, Milton J.; Moore, David D. (2015-02-09).
459:
The discovery of bile acid ligands for FXR led Moore and colleagues to demonstrate a strong link between nuclear hormone receptors and
479:
268:
216:
1489:"Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation"
1832:
595:"A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements"
279:
94:
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Huang, Wendong; Zhang, Jun; Washington, Michele; Liu, Jun; Parant, John M.; Lozano, Guillermina; Moore, David D. (2005-06-01).
401:
Moore published a series of studies beginning in 1994 identifying and describing the constitutive androstane receptor (CAR), a
376:
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is 303, and his publications have been cited over 87,000 times as of August 2023 according to his Google
Scholar page.
1061:"Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the CYP2B10 Gene"
977:"Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries"
1595:"Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver"
1391:"Xenobiotic Stress Induces Hepatomegaly and Liver Tumors via the Nuclear Receptor Constitutive Androstane Receptor"
433:
207:
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452:, an orphan nuclear receptor he had first purified in 1995, and an upstream regulator of SHP. He also identified
383:
and its relation to growth hormone expression. In collaboration with P. Reed Larsen, he identified several novel
287:
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102:
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Lee, Yoon-Kwang; Dell, Helen; Dowhan, Dennis H.; Hadzopoulou-Cladaras, Margarita; Moore, David D. (2000-01-01).
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325:
59:
879:"Conservation of the DNA binding domain and other properties between porcine and rat glucocorticoid receptors"
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1116:"An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors"
706:
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707:"Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors"
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877:
Marks, Andrew R.; Moore, David D.; Buckley, Douglas I.; Gametchu, Bahiru; Goodman, Howard M. (June 1986).
372:
202:
394:, established the laboratory manual series Current Protocols in Molecular Biology, which was acquired by
333:
1440:"Spontaneous Development of Liver Tumors in the Absence of the Bile Acid Receptor Farnesoid X Receptor"
820:"The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor"
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501:
Moore has received many academic prizes for his work, including the Edwin B. Astwood Award from the
352:
in 1979 in the laboratory of Howard
Goodman in the Department of Biochemistry and Biophysics at the
305:
Moore was born in
Brookline, Massachusetts in 1952, and was adopted by Clinton and Emily Moore from
1438:
Yang, Fan; Huang, Xiongfei; Yi, Tangsheng; Yen, Yun; Moore, David D.; Huang, Wendong (2007-02-01).
509:. Moore was elected to the National Academy of Sciences in 2019 and in 2022 became a fellow at the
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1228:"Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice"
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In 1997, Moore was recruited to the
Department of Molecular and Cellular Biology, then headed by
418:
878:
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267:. He is a Professor and Chair of the Department of Nutritional Sciences & Toxicology at the
30:
655:"Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)"
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Zhang, Yuxia; Xu, Ping; Park, Kyungtae; Choi, Yunhee; Moore, David D.; Wang, Li (July 2008).
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Moore, D D; Marks, A R; Buckley, D I; Kapler, G; Payvar, F; Goodman, H M (February 1985).
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Moore became professor of the
Department of Nutritional Sciences & Toxicology at the
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1059:
Honkakoski, Paavo; Moore, Rick; Washburn, Kimberly A.; Negishi, Masahiko (1998-04-01).
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Koenig, R J; Warne, R L; Brent, G A; Harney, J W; Larsen, P R; Moore, D D (July 1988).
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Prost, E.; Koenig, R. J.; Moore, D. D.; Larsen, P. R.; Whalen, R. G. (1988-07-11).
918:"Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor"
468:
337:
1538:"Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis"
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1301:
1186:
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593:
Baes, M; Gulick, T; Choi, H S; Martinoli, M G; Simha, D; Moore, D D (March 1994).
1645:"Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease"
1042:
781:"Sequence organization of the origins of DNA replication in lambdoid coliphages"
464:
375:
in 1981, and became a founding member of the
Department of Molecular Biology at
779:
Moore, David D.; Denniston, Katherine J.; Blattner, Frederick R. (June 1981).
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1333:"Androstane metabolites bind to and deactivate the nuclear receptor CAR-β"
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571:
Nutritional
Sciences & Toxicology | University of California, Berkeley
230:
Sequence organization of lambdoid bacteriophage origins of DNA replication
1407:
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1076:
1777:"New fellows of the American Association for the Advancement of Science"
1332:
1553:
486:
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1611:
1504:
445:
223:
1753:"Meet David Moore the Society's 2021 Transatlantic Medal Lecturer"
1348:
456:
metabolites and xenobiotics as ligands for CAR during this time.
405:
nuclear receptor which senses and responds to endobiotic and
1286:"Bile Acids: Natural Ligands for an Orphan Nuclear Receptor"
1114:
Seol, Wongi; Choi, Hueng-Sik; Moore, David D. (1996-05-31).
755:"Dr. David Moore elected into National Academy of Sciences"
379:. There, Moore's research lab investigated the activity of
463:. He showed that disruption of CAR, FXR, and SHP leads to
371:
Moore joined the faculty of the
Department of Genetics at
1828:
Members of the United States
National Academy of Sciences
398:
in 1995 and later expanded to include additional titles.
390:
In 1987, Moore, alongside other colleagues including
1384:
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482:in 2020, where he became department chair in 2022.
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171:
158:
American Association for the Advancement of Science
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108:
89:
66:
40:
21:
213:Korea Advanced Institute of Science and Technology
328:in 1974, he received his Ph.D. in 1979 from the
1649:Proceedings of the National Academy of Sciences
922:Proceedings of the National Academy of Sciences
824:Proceedings of the National Academy of Sciences
705:Seol, W; Choi, H S; Moore, D D (January 1995).
320:After completing his undergraduate degree at
8:
356:, where he studied the genetic sequence of
1823:University of California, Berkeley faculty
29:
18:
1751:Endocrinology, Society for (2021-10-18).
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421:. He later found that SHP regulates the
522:
354:University of California, San Francisco
194:University of California, San Francisco
1838:University of Wisconsin–Madison alumni
1034:Current Protocols in Molecular Biology
275:series of laboratory manuals in 1987.
259:(born August 21, 1952) is an American
1054:
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505:and the Transatlantic Medal from the
7:
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271:. He was a founding editor for the
480:University of California, Berkeley
269:University of California, Berkeley
217:University of California, Berkeley
14:
263:known for his work investigating
1727:"Past Laureate Award Recipients"
280:constitutive androstane receptor
95:constitutive androstane receptor
883:Journal of Steroid Biochemistry
330:University of Wisconsin–Madison
79:University of Wisconsin–Madison
1175:Molecular and Cellular Biology
599:Molecular and Cellular Biology
377:Massachusetts General Hospital
293:In 2019 he was elected to the
198:Massachusetts General Hospital
1:
1818:American molecular biologists
1457:10.1158/0008-5472.CAN-06-1078
1302:10.1126/science.284.5418.1365
1187:10.1128/MCB.20.1.187-195.2000
1132:10.1126/science.272.5266.1336
307:The Home for Little Wanderers
895:10.1016/0022-4731(86)90369-9
797:10.1016/0378-1119(81)90151-7
295:National Academy of Sciences
139:National Academy of Sciences
16:American molecular biologist
440:. There, he identified the
1854:
759:Baylor College of Medicine
434:Baylor College of Medicine
340:under Frederick Blattner.
208:Baylor College of Medicine
507:Society for Endocrinology
385:thyroid hormone receptors
288:small heterodimer partner
265:nuclear hormone receptors
250:
164:
154:, Falk Foundation (2022)
146:Society for Endocrinology
103:small heterodimer partner
28:
724:10.1210/mend.9.1.7760852
326:Providence, Rhode Island
301:Early life and education
60:Brookline, Massachusetts
1833:Brown University alumni
1662:10.1073/pnas.0909731106
1395:Molecular Endocrinology
1232:Molecular Endocrinology
1043:10.1002/(issn)1934-3647
935:10.1073/pnas.85.14.5031
711:Molecular Endocrinology
659:Molecular Endocrinology
653:Seol, W. (1998-10-01).
366:glucocorticoid receptor
350:postdoctoral researcher
286:(FXR) in 1995, and the
1065:Molecular Pharmacology
993:10.1093/nar/16.13.6248
981:Nucleic Acids Research
373:Harvard Medical School
348:Moore began work as a
203:Harvard Medical School
129:Edwin B. Astwood Award
1542:Nature Communications
837:10.1073/pnas.82.3.699
672:10.1210/me.12.10.1551
611:10.1128/MCB.14.3.1544
403:constitutively active
334:origin of replication
144:Transatlantic Medal,
1408:10.1210/me.2004-0520
1244:10.1210/me.2015-1295
1077:10.1124/mol.53.4.597
450:farnesoid X-receptor
362:DNA binding activity
358:human growth hormone
338:bacteriophage lambda
284:farnesoid X receptor
99:farnesoid X receptor
1655:(44): 18831–18836.
1296:(5418): 1365–1368.
1126:(5266): 1336–1339.
473:fatty liver disease
315:Madeira High School
313:and graduated from
309:. He was raised in
261:molecular biologist
152:Adolf Windaus Prize
35:David Moore in 2017
1757:The Endocrine Post
1707:scholar.google.com
1554:10.1038/ncomms6944
419:retinoid receptors
415:estrogen receptors
392:Frederick M Ausbel
257:David Dudley Moore
246:Frederick Blattner
44:David Dudley Moore
1731:www.endocrine.org
1612:10.1002/hep.21632
1505:10.1002/hep.22342
1343:(6702): 612–615.
928:(14): 5031–5035.
665:(10): 1551–1557.
544:www.nasonline.org
503:Endocrine Society
497:Awards and honors
273:Current Protocols
254:
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176:Molecular biology
166:Scientific career
133:Endocrine Society
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1703:"David D. Moore"
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1401:(6): 1646–1653.
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540:"David D. Moore"
536:
430:Bert W. O'Malley
322:Brown University
311:Cincinnati, Ohio
242:Doctoral advisor
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71:Brown University
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1444:Cancer Research
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444:and xenobiotic
423:circadian clock
381:thyroid hormone
346:
344:Research career
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290:(SHP) in 1996.
282:(CAR) in 1994,
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67:Alma mater
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53:August 21, 1952
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438:Houston, Texas
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