209:, asked David to rebuild the Institute's electron microscope which had been damaged while researchers tried to activate it. For a few months, David was working as a military doctor during the day and at the Weizmann Institute of Science at night. In 1955, upon his completion of military service, he began working in the Department of Polymers of the Weizmann Institute. In addition to restoring the function of the electron microscope, he developed and prepared the microtome and other devices necessary for the operation of the electron microscope. Later he founded the Electron Microscopy Laboratory at the Weizmann Institute. His pearly research in the Institute's Electron Microscopy Laboratory involved the membrane structure of erythrocytes, their adherence and thrombocytes. In 1957, while working at the Weizmann Institute David Danon founded with Dr. Kalman the Department of Physiology and Anatomy of Animals, at the Faculty of Agriculture in Rehovot where he taught until 1962. His research during this period continued to focus on erythrocytes and thrombocytes, as well as the interaction between these cells and the influenza virus. In 1964 he was appointed head of the Section for Biological Ultrastructure at the Weizmann Institute. In 1967 he was assigned the title of "professor of biology." Prof. Danon was the founder and first President of the Israeli Society for Electron Microscopy and President of the Israeli Society of Hematology and Blood Transfusion. At this time he developed and built Fragiligraph, โ a device that enables automatic registration of osmotic fragility curve of erythrocytes, later produced by "Elron". . In later years, Prof. Danon became interested in the process of aging of
213:, and joined the Israeli Association of Gerontology. In 1975 he was elected president of the International Association of Gerontology, and was the first and only Israeli scientist to date to serve in this position (1975-1978). Between the years 1978 to 1987, Prof. Danon served as the Chief Scientist of the Israeli Ministry of Health. In 1979, he was appointed director of the Center for Research on Aging at the Weizmann Institute, a position he held until his retirement from the Institute in 1987. During a Sabbatical in geriatric medicine at Montefiore Hospital in New York in 1984-1985, he devoted major efforts to alleviating the suffering of patients with pressure ulcers. Between the years 1998 to 1991 he served as scientific advisor to the Israeli Ministry of Labor and Social Affairs. Upon his retirement from Weizmann Institute, Prof. Danon was the director of the Waldenberg Gerontology Research Center in New Orleans, Louisiana from 1987 to 1992. At that time while continuing his research on the healing of pressure ulcers, he discovered the critical role of macrophages (a special type of white blood cell) in wound healing. He discovered that the injection of
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were prepared from blood units of standard donated blood, using white blood cells that are typically considered undesirable in routine blood transfusions. Macrophages were prepared from a blood unit in a closed sterile system that consisted of a number of interconnected plastic bags. According to the method developed by Prof. Danon, macrophages activation is done by the "hypo-osmotic shock" without any of the toxic materials usually used to activate cells. This work was carried out in the laboratories of Magen David Adom (the
Israeli blood bank), and after many years of work the project was crowned with success. As of 1998, the Israeli Ministry of Health has approved the use of activated macrophage injections for the treatment of serious pressure ulcers and other difficult wounds that are not responsive to standard treatments. The method has been so effective, that it is included as covered within Israel's government health coverage plan.
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first year of medical school and his having to learn the French language, he excelled. During his second year in medical school he began to do research. His research was published in the scientific literature between the years 1948 and 1950. One of his
Important projects was the study of the structure of the human nervous system. The use of conventional microscopes for this work was an obstacle due to the limited resolution capability of the common optical microscope. In order to facilitate the use of the more sophisticated electron microscope it was necessary to cut thinner slices of tissue. Thus, David Danon developed the
193:(1973). During the War of Attrition, he developed a unique device for checking the cardiac activity of the wounded on the field of battle, permitting medical personnel in the field to determine whether an injured soldier was still alive. Immediately after the Yom Kippur War, David canceled a planned sabbatical year in the United States and enlisted instead in the Israeli Air Force for one year of service, to assist in improving the capacity of the airborne medical evacuation unit. In 1978, he was recognized by the Israeli Air Force for his commitment to the Air Force medical unit and for all the above-mentioned activities.
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266:. Throughout his life, beginning with his teen years, David Danon was painting: when he was imprisoned at Latrun, while attending the University of Geneva Medical School, during the wars in which he served in the airborne medical evacuation unit, while on sabbatical, while traveling, during Army service, and in every place where he worked as a scientist. Some of his paintings were exhibited in research and medical institutions in which he worked. In 2011 David Danon had a solo exhibition at the "Foyer gallery" in Petah Tikva, by the name "Seventy Years of Painting".
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136:. While David remained in exile in Geneva to continue his studies, several of his Irgun friends and compatriots were either injured or killed when Israeli forces clashed with Irgun fighters from the Altalena and ultimately shelled the ship. Later, David was sent to ][Tunis\\ to organize self-defense among the Tunisian Jewish community.
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from young mice, accelerated the healing of wounds in old mice. From 1993 onwards Prof. Danon devoted himself entirely to the development of a unique, remarkably simple, yet new method for the treatment of severe wounds, based on the injection of "activated" macrophages. In this method, Macrophages
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Medical School (where David's father had professional connections) and by committing to the
British that David would not return to Palestine for the duration of the British Mandate. Per agreement with the British, David traveled to Geneva by ship within one or two days of his release from Latrun and
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Zuloff-Shani A, Adunsky A, Even-Zahav A, Semo H, Orenstein A, Tamir J, Regev E, Shinar E, Danon D. Hard to heal pressure ulcers (stage III-IV): efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial. Arch
Gerontol Geriatr. 2010
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on
December 31, 1946 late in the first semester pursuant to the agreement between his father and the British Mandate authorities, essentially exiling him from Palestine for the duration of the British Mandate. He arrived without any knowledge of the French language. Despite his late start in his
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177:(the commander of the Israeli Air Force at that time) ordered David to establish the airborne medical evacuation unit and appointed him first commander of the unit. In later years, David participated in the airborne evacuation of Israeli military casualties during the
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began his medical studies. By the end of 1947, however, he postponed his medical studies and returned to Irgun activity, seeking out and collecting weapons in France to be sent to Irgun fighters in
Palestine. He did so primarily by obtaining weapons left over from
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75:. David's parents were doctors: his mother was a gynecologist and his father was a family physician. His parents were Zionists and in 1924 they immigrated with three children (Nora, David and Ida) and settled in the Jaffa section of Tel Aviv.
27:, and a painter. He was the inventor of a unique treatment for the healing of pressure ulcers and other severe wounds that do not respond to conventional treatments. Before the creation of the state of Israel, he was a commander in
99:, and was executed in Egypt for the assassination of Lord Moyne). Over time, as a member of the Irgun, David Danon was appointed a commander in the punch units. With the declaration of rebellion against the British Mandate by
31:, the Zionist paramilitary group also known as "Etzel". He was the founder and the first commander of the Israeli Air Force's first airborne military medical evacuation unit, the founder and first president of the
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Zuloff-Shani A, Kachel E, Frenkel O, Orenstein A, Shinar E, Danon D. Macrophage suspensions prepared from a blood unit for treatment of refractory human ulcers. Transfus Apher Sci. 2004 Apr;30(2):163-7.
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Immediately after graduation from high school, David Danon joined the Irgun (Etzel) and his nom de guerre was "Ehud". He joined the Irgun together with his two classmates and close boyhood friends
242:, Prof Danon came to the conclusion that it was preferable for him to continue to engage in scientific research. In 1989 he was awarded the prize of the International Association of Aging (
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Menachem Begin suggested nominating Prof. Danon president of Israel. However, after consultation on this issue with his colleagues at the
Weizmann Institute, especially president
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from sympathetic former members of the French
Resistance. Having collected the needed arms, he prepared to send them from France to the Irgun on the ill-fated ship, the "
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Amiela
Globerson. Prof. David Danon: Israel gerontology leader, physician and scientist in the biology of aging. Gerontology: A Journal on Aging. 2008; 58 (2):141โ149.
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Joseph Evron. The Jewish insurgency against the
British in Palestine. Publishing โ Ministry of Defense, Jerusalem. 2001; pages 44โ43, 47, 49, 53, 56โ55, 75, 294, 354.
103:, Danon participated in several of the first attacks against British government targets, and was sent to Beirut to try to obtain weapons. During what was then dubbed
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Eitan Livni. I.Z.L. Operations and Underground. Edanim Publishers, Yedioth Ahronoth Books, Jerusalem. 1987; pages 33, 37, 43, 70โ68, 96, 97, 134, 166, 303โ301
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Danon D, Kowatch MA, Roth GS. Proc Natl Acad Sci U S A. Promotion of wound repair in old mice by local injection of macrophages. 1989 Mar;86(6):2018โ20.
115:. Seven month later, David's father succeeded in negotiating his release from the British by promising to register David as a medical student at the
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Danon D. An instrument to trim plastic Specimen blocks for electron microscopy prior to sectioning. J Biophys Biochem Cytol. 1961 Mar; 9: 726โ8.
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346:"This Day in Jewish History A Future AIDS Warrior Enters the World - This Day in Jewish History - Israel News - Haaretz Israeli News Source"
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157:. The University of Geneva recognized David for his development of this innovative device by awarding him the "best dissertation" award.
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Following the 1948 declaration of the State of Israel and following the completion of his medical studies, in 1953 David returned to
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Rimon A, Rimon S, Danon D. Biochemical and electron Microscopic study of Preserved Erythocytes. Transfusion. 1963 MayโJun; 3: 161โ6.
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Award for "lifetime achievement in the service of the national idea and the State of Israel and his contribution to science."
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111:, he was arrested based on information obtained by an informant, taken to jail in Jaffa, and later sent to detention in
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Danon D. Structural variations of the sympathetic ganglia synapses in man. Acta Anat (Basel) 1951; 13 (1โ2): 163โ70.
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https://web.archive.org/web/20141025164424/http://www.petah-tikva.muni.il/Documents/TARBOT%2011.pdf
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Menahem Malatzky. The one truth and no other. Yedioth Ahronoth Books, Tel Aviv. 1995; pages 16, 129
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23:(October 17, 1921 โ October 17, 2015) was a physician, a scientist, a leader in the study of the
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91:'s counter-terrorism advisor, and Prime Minister Begin's Ambassador to the United States) and
499:"ืืื ื ืืืจ ืืฆืืง ื ืืื ืื ืฉืื ืืืื ืช ืืฉืจืื? ืืืืืืื ืืืืืจื ืืงืืขืื ืืืืื ืืืืืืืช 90 - ืืืื - ืืืจืฅ"
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Prof. David Danon (first from left) receives the Jabotinsky Award in 1998.
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David Danon left a wife, three children and seven grandchildren.
71:(Bulgarian: ะะฐะทะฐัะดะถะธะบ, also spelled as Pazardjik or Pazarjik),
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Talk to me with Flowers. Institute. 2010; 60 : 42โ43.
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Danon D. Schweiz Med Wochenschr. 1948 May 8; 78 (18): 446.
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David Danon was born in 1921 to Regina and Moshe Danon in
292:"ืืฆืขืจ ืจื ืื ื ืืืืืขืื ืขื ืคืืืจืชื ืฉื ืคืจืืคืกืืจ ืืื ืื ืื ื"ื"
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While David was still serving in the Air Force, Prof.
58:Prof. David Danon in Weizmann Institute of Science
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169:and began his mandatory military service in the
619:Academic staff of Weizmann Institute of Science
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634:Bulgarian emigrants to Mandatory Palestine
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439:. Iagg.info. Archived from
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222:Awards and acknowledgments
49:Israeli Ministry of Health
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344:Bar, Zvi (2013-07-09).
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197:Scientific activity
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134:War of Independence
63:Childhood and youth
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264:Avni Art Institute
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105:The Hunting Season
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