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213:(July 3, 1937 - June 24, 2020) was a Canadian biochemist and geneticist known for his basic work on proteins that regulate calcium flux through the sarcoplasmic reticulum (SR), thereby regulating muscle contraction and relaxation, and for his discoveries in the field of muscle diseases caused by genetic defects in calcium regulatory proteins.
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MacLennan made fundamental contributions to our understanding of the mechanism of ion transport by SR calcium pumps, the storage of calcium in the SR by acidic lumenal proteins and the release of calcium from the SR by calcium release channels. He led teams that defined the genetic basis for the
244:. In 1969, he was appointed associate professor in the Banting and Best Department of Medical Research and, later, professor (1974), chair (1978–1990), J. W. Billes Professor of Medical Research (1987–2007) and university professor (1993–2015).
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resulted in a diagnostic test that has decreased the incidence of the disease dramatically, with substantial economic benefits to the swine industry.
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438:"Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban"
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Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U; et al. (2003).
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2000 Royal
Society Glaxo Wellcome Prize, Medal and Lecture
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2004 Honorary Member of the
Japanese Biochemical Society
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2001 Honorary Doctor of
Science, University of Manitoba
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1990 National
Lecturer Award of the Biophysical Society
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Foreign associates of the
National Academy of Sciences
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1974 Ayerst Award of the
Canadian Biochemical Society
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Biographical
Memoirs of Fellows of the Royal Society
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166:Compartmentation of organic acids in plant tissues
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499:"David Herman MacLennan. 3 July 1937—24 June 2020"
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240:and an assistant professor (1964–1968) at the
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482:: CS1 maint: multiple names: authors list (
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27:For the Scottish theatre practitioner, see
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412:"Terrence Donnelly Centre Lab Page"
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391:"University of Manitoba Lab Page"
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313:2001 Foreign Associate of the
31:. For the CEO of Cargill, see
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613:Canadian Medical Hall of Fame
497:Reithmeier, Reinhart (2021).
344:2015 Foreign Honorary Member
340:Canadian Medical Hall of Fame
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262:porcine stress syndrome
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194:David Herman MacLennan
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366:"MacLennan Lab Page"
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1071:Wilbert Keon
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478:cite journal
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420:. Retrieved
416:the original
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374:. Retrieved
370:the original
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299:Killam Prize
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150:Institutions
140:Biochemistry
129:
88:(2020-06-24)
67:July 3, 1937
1791:2020 deaths
1786:1937 births
1760:Erwin Neher
1677:Tony Pawson
1643:Dusa McDuff
1633:Tak Wah Mak
1531:Nick Barton
1457:Salim Yusuf
1380:Emily Stowe
1276:Vera Peters
1187:Maud Menten
1167:Marco Marra
1162:Tak Wah Mak
1152:John McCrae
1040:David Hubel
810:Max Cynader
780:Bruce Chown
752:John Browne
662:Murray Barr
509:: 317–333.
1780:Categories
1702:John Tooze
1583:Guy Dodson
1398:James Till
1340:Hans Selye
1317:Ian Rusted
1312:Claude Roy
1025:Jack Hirsh
833:John Dirks
818:Paul David
422:2013-08-09
397:2013-08-09
376:2013-08-09
252:diseases,
71:Swan River
63:1937-07-03
1717:Bob White
967:Jean Gray
957:Phil Gold
919:Terry Fox
795:May Cohen
525:235598967
106:Education
1505:elected
672:John Bel
572:Archived
560:Archived
470:12253445
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216:Born in
144:Genetics
115:(B.S.A.)
100:, Canada
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1733:Foreign
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1507:in 1994
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442:Science
98:Ontario
94:Toronto
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248:human
232:under
170:(1963)
168:
161:Thesis
136:Fields
521:S2CID
466:S2CID
352:Notes
323:2001
297:1997
285:1991
208:
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200:
484:link
458:PMID
210:FRSC
202:OOnt
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511:doi
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