39:
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208:. Recent studies in his laboratory are focused on examining the organization and regulation of gene expression in living mammalian cells. His laboratory has developed approaches to elucidate the spatial and temporal aspects of gene expression and in identifying and characterizing the function of nuclear retained
224:
and follow in real-time its mRNA and protein products; the elucidation of a rapid-response mechanism of regulating gene expression through RNA nuclear retention; identification of a mechanism by which a single genetic locus can produce a long nuclear retained non-coding RNA and a small cytoplasmic
215:
His most seminal research accomplishments include the direct visualization in living cells of the recruitment of factors involved in gene expression to active genes; the development of a biochemical fractionation approach to purify a sub-nuclear domain
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in
Houston, Texas. In 1985 he relocated to Cold Spring Harbor Laboratory and has been promoted through the ranks to his current position of Professor. In 2007 he was appointed Director of Research.
1051:
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Arun, G.; Diermeier, S.; Ackerman, M.; Chang, K.-C.; Wilkinson, J.E.; Hearn, S.; Kim, Y.; MacLeod, A.R.; Krainer, A.R.; Norton, L.; Brogi, E.; Egeblad, M.; Spector, D.L. (2016).
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229:-like transcript, the identification and characterization of a long nuclear retained non-coding RNA that is involved in organizing a sub-nuclear organelle (
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2017: Elected Fellow, The
American Society for Cell Biology, Lifetime Fellow Recognition for Distinguished Contributions to the Advancement of Cell Biology
629:
Janicki SM, Tsukamoto T, Salghetti SE, Tansey WP, Sachidanandam R, Prasanth KV, Ried T, Shav-Tal Y, Bertrand E, Singer RH, Spector DL (March 2004).
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Spector is a pioneer in unraveling our understanding of the inner workings of the cell nucleus. His early investigations centered on the unusual
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819:"MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles"
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Tsukamoto T, Hashiguchi N, Janicki SM, Tumbar T, Belmont AS, Spector DL (December 2000). "Visualization of gene activity in living cells".
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220:) and characterize its protein constituents; the development of a live cell imaging system to visualize a stably integrated
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Misteli T, Cáceres JF, Spector DL (May 1997). "The dynamics of a pre-mRNA splicing factor in living cells".
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Prasanth KV, Prasanth SG, Xuan Z, Hearn S, Freier SM, Bennett CF, Zhang MQ, Spector DL (October 2005).
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in 1980. After completing his Ph.D. he accepted a position as
Assistant Professor in the Department of
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Basic
Methods in Microscopy Protocols and Concepts from Cells: A Laboratory Manual (from CSHL Press)
209:
350:"CEO of PepsiCo Americas Beverages Addresses More Than 2,600 Graduates at Commencement Exercises"
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76:
17:
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770:"3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA"
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868:"Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs"
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results in the differentiation of mammary tumors and a significant reduction in metastasis.
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680:"Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation"
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December 6, 1952) is a cell and molecular biologist best recognized for his research on
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917:"Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss"
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Basic methods in microscopy: protocols and concepts from cells: a laboratory manual
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Saitoh N, Spahr CS, Patterson SD, Bubulya P, Neuwald AF, Spector DL (August 2004).
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153:
498:"Purification and biochemical characterization of interchromatin granule clusters"
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Spector was born in New York City. He received a
Bachelor of Science degree from
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Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL (March 2009).
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In addition, Spector has co-edited numerous microscopy techniques manuals (i.e.
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Since 2010: Robert B. Gardner Jr. Professor, Cold Spring Harbor
Laboratory.
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Elected
Associate Foreign Member, European Molecular Biology Organization
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Mintz PJ, Patterson SD, Neuwald AF, Spahr CS, Spector DL (August 1999).
631:"From silencing to gene expression: real-time analysis in single cells"
160:(CSHL). From 2007 to 2023, he served as Director of Research of CSHL.
993:(2nd ed.). Plainview, N.Y: Cold Spring Harbor Laboratory Press.
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474:
423:"Spector, David L. Publications - CSHL Scientific Digital Repository"
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2012: Alumni
Achievement Award, Herbert H. Lehman College, New York.
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Zhao R, Nakamura T, Fu Y, Lazar Z, Spector DL (November 2011).
1041:
88:
Alumni
Achievement Award, Herbert H. Lehman College, New York
233:), and determining that knockout or knockdown of the lncRNA
729:"Regulating gene expression through RNA nuclear retention"
1062:
The
Nucleus (Perspectives in Biology) (from CSHL Press)
1057:
Live Cell Imaging: A Laboratory Manual (from CSHL Press)
261:
1973: City College of New York, Bedesem Award in Biology
1018:. Plainview, N.Y: Cold Spring Harbor Laboratory Press.
968:. Plainview, N.Y: Cold Spring Harbor Laboratory Press.
547:"Proteomic analysis of interchromatin granule clusters"
866:
Mao YS, Sunwoo H, Zhang B, Spector DL (January 2011).
252:, that are used in laboratories throughout the world.
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2006: Winship Herr Award for Excellence in Teaching,
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45:
29:
768:Wilusz JE, Freier SM, Spector DL (November 2008).
356:. Lehman College. May 31, 2012. Archived from
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989:Spector DL, Goldman RD, Swedlow JR (2009).
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380:"European Molecular Biology Organization"
440:. Boston: Academic Press. p. 545.
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296:European Molecular Biology Organization
290:American Academy of Arts & Sciences
93:American Academy of Arts & Sciences
991:Live Cell Imaging: A Laboratory Manual
246:Live Cell Imaging: A Laboratory Manual
1016:The Nucleus (Perspectives in Biology)
394:"Model of the Mammalian Cell Nucleus"
277:The American Society for Cell Biology
7:
266:Watson School of Biological Sciences
25:
156:. He is currently a Professor at
18:David L. Spector (cell biologist)
314:
294:2014: Elected Associate Member,
172:in 1973, a master's degree from
964:Goldman RD, Spector DL (2006).
164:Education and faculty positions
117:Cell biology, Molecular biology
1014:Spector DL, Misteli T (2010).
1:
1090:American molecular biologists
647:10.1016/S0092-8674(04)00171-0
270:Cold Spring Harbor Laboratory
158:Cold Spring Harbor Laboratory
126:Cold Spring Harbor Laboratory
275:2009-2012: Council Member,
242:Basic Methods in Microscopy
1106:
1042:Spector Laboratory at CSHL
786:10.1016/j.cell.2008.10.012
746:10.1016/j.cell.2005.08.033
190:Baylor College of Medicine
174:Herbert H. Lehman College
131:
106:
73:Herbert H. Lehman College
36:
514:10.1093/emboj/18.15.4308
300:2016: Rutgers 250 Fellow
170:City College of New York
69:City College of New York
563:10.1091/mbc.E04-03-0253
196:Professional activities
176:in 1977, and a Ph.D.in
59:New York City, New York
1047:Research Summary, CSHL
933:10.1101/gad.270959.115
354:Lehman College website
288:2014: Elected Member,
835:10.1101/gr.087775.108
248:), and a treatise of
308:Notes and references
210:long non-coding RNAs
202:chromosome structure
436:Spector DL (1984).
324:has a profile for
182:Rutgers University
100:Rutgers 250 Fellow
77:Rutgers University
1025:978-0-87969-894-2
1000:978-0-87969-893-5
975:978-0-87969-751-8
447:978-0-12-656520-1
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327:David L. Spector
256:Honors and awards
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108:Scientific career
16:(Redirected from
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218:nuclear speckles
154:nuclear dynamics
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138:David L. Spector
91:Elected Member,
56:December 6, 1952
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31:David L. Spector
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551:Mol. Biol. Cell
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508:(15): 4308–20.
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438:Dinoflagellates
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360:on 18 June 2012
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406:. Retrieved
402:the original
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362:. Retrieved
358:the original
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231:paraspeckles
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186:Pharmacology
178:cell biology
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122:Institutions
107:
1080:1952 births
398:Spector Lab
250:The Nucleus
1074:Categories
823:Genome Res
408:2012-08-01
329:(Q5236255)
144:1952-12-06
52:1952-12-06
921:Genes Dev
951:26701265
902:21170033
853:19106332
804:19041754
755:16239143
714:21983563
665:15006351
616:11146650
581:15169873
532:10428969
364:3 August
942:4701977
893:3007124
844:2661813
795:2722846
705:3210065
656:4942132
523:1171507
483:9168118
322:Scholia
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569:
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502:EMBO J
481:
463:Nature
444:
235:Malat1
140:(born
114:Fields
83:Awards
180:from
1020:ISBN
995:ISBN
970:ISBN
947:PMID
898:PMID
849:PMID
800:PMID
774:Cell
751:PMID
733:Cell
710:PMID
661:PMID
635:Cell
612:PMID
577:PMID
528:PMID
479:PMID
442:ISBN
366:2012
227:tRNA
152:and
46:Born
937:PMC
929:doi
888:PMC
880:doi
839:PMC
831:doi
790:PMC
782:doi
778:135
741:doi
737:123
700:PMC
692:doi
651:PMC
643:doi
639:116
604:doi
567:PMC
559:doi
518:PMC
510:doi
471:doi
467:387
204:of
188:at
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
