313:. In collaborative work with Mark Akeson, a post-doctoral student at the time, the two established methods for monitoring proton permeation through ion channels such as gramicidin. In 1989, while returning from a scientific meeting in Oregon, Deamer conceived that it might be possible to sequence single molecules of DNA by using an imposed voltage to pull them individually through a nanoscopic channel. The DNA sequence could be distinguished by the specific modulating effect of the four bases on the ionic current through the channel. In 1993, he and Dan Branton initiated a research collaboration with John Kasianowitz at NIST to explore this possibility with the
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309:. Conversations with Bangham inspired his research on the role of membranes in the origin of life, and in 1985 Deamer demonstrated that the Murchison carbonaceous meteorite contained lipid-like compounds that could assemble into membranous vesicles. Deamer described the significance of self-assembly processes in his 2011 book
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may be feasible. George Church at
Harvard had independently proposed a similar idea, and Church, Branton and Deamer decided to initiate a patent application which was awarded in 1998. Mark Akeson joined the research effort in 1997, and in 1999 published a paper showing that the hemolysin channel, now
354:
Deamer is also the co-author with science writer
Wallace Kaufman of a sci-fi novel, The Hunt for FOXP5: A Genomic Mystery Novel (Springer, 2016). Through characters in American universities and Kazakhstani science and politics the authors explore the ethical complexity of editing human genes.
561:, Church, George; Deamer, David W.; Branton, Daniel; Baldarelli, Richard; Kasianowicz, John, "Characterization of Individual Polymer Molecules Based on Monomer-Interface Interactions", issued August 18, 1998, assigned to President and Fellows of Harvard College
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301:, revealing for the first time particles related to functional ATPase enzymes within the membranes of sarcoplasmic reticulum. After spending sabbaticals in England at the University of Bristol in 1971 and with
246:. Deamer has made significant contributions to the field of membrane biophysics. His work led to a novel method of DNA sequencing and a more complete understanding of the role of membranes in the
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690:"Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules"
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He was awarded a
Guggenheim Fellowship in 1985, which supported research at the Australian National University in Canberra to investigate organic compounds in the
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281:, where the three brothers attended Westerville High School. In 1957, Deamer submitted his research on self-organizing protozoa to the
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Loman, N.J.; Quick, J.; Simpson, J.T. (2015). "A complete bacterial genome assembled de novo using only nanopore sequencing data".
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to sequence E. coli DNA with 99.4% accuracy relative to the established 5.4 million base pair genome. Despite earlier skepticism,
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that year. He was awarded a full scholarship to Duke
University, where he completed a bachelor's degree in chemistry in 1961.
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Deamer, D.W. (1985). "Boundary structures are formed by organic compounds of the
Murchison carbonaceous chondrite".
257:. He served as the president of the International Society for the Study of the Origin of Life from 2013 to 2014.
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while his mother Zena cared for Deamer and his two brothers, Richard and John. In 1952, the family moved to
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242:(born April 21, 1939) is an American biologist and Research Professor of Biomolecular Engineering at the
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579:"Proton conductance in the gramicidin water wire: Model for proton conductance in the FoF1 ATPase?"
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The Hunt for FOXP5: A Genomic
Mystery Novel, Wallace Kaufman and David Deamer, Springer, 2016,
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device to selected researchers. The first publications appeared in 2015, one of which used the
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Deamer, D.W.; Branton, D. (1967). "Fracture planes in an ice-bilayer model membrane system".
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First life : discovering the connections between stars, cells, and how life began
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330:(ONT) licensed the patents describing the technology and in 2014 released the MinION
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or has been extensively edited by the subject or by someone connected to the subject
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628:"Characterization of individual polynucleotide molecules using a membrane channel"
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Akeson, M.; Branton, D.; Kasianowicz, J.J.; Brandin, E.; Deamer, D.W. (1999).
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The effect of alkaline earth ions on fatty acid and phospholipid monolayers
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channel, and in 1996 published the first paper demonstrating that
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811:"Radical New DNA Sequencer Finally Gets into Researchers' Hands"
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Kasianowicz, J.; Brandin, E.; Branton, D.; Deamer, D.W. (1996).
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As a young professor at UC Davis, Deamer continued to work with
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Duke
University Trinity College of Arts and Sciences alumni
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Zone in With Zon: What's
Trending in Nucleic Acid Research
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Regalado, Antonio; Quick, J.; Simpson, J.T. (2014-09-17).
425:"Ultrastructure of sarcoplasmic reticulum preparations"
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Krol, Aaron; Quick, J.; Simpson, J.T. (2014-12-22).
529:. Berkeley, CA, US: University of California Press.
883:Zon, Jerry; Quick, J.; Simpson, J.T. (2015-09-15).
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Proceedings of the
National Academy of Sciences USA
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285:and was among the 40 winners who were invited to
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836:"Pint-sized DNA sequencer impresses first users"
46:policy. There may be relevant discussion on the
42:It may need editing to conform to Knowledge's
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992:University of California, Davis faculty
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265:Deamer's father, also David, worked at
910:"Nanopore Sequencing Is Here to Stay"
305:in 1975, Deamer became interested in
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987:People from Santa Monica, California
244:University of California, Santa Cruz
219:University of California, Santa Cruz
423:Deamer, D.W.; Baskin, R.J. (1969).
885:"Nanopore Sequencing: 20 Years On"
283:Westinghouse Science Talent Search
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577:Akeson, M.; Deamer, D.W. (1991).
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714:10.1016/s0006-3495(99)77153-5
595:10.1016/s0006-3495(91)82034-3
746:"Oxford Nanopore Technology"
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344:third generation sequencing
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271:Santa Monica, California
429:Journal of Cell Biology
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525:Deamer, David (2011).
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559:US patent 5795782
176:Ohio State University
159:Ohio State University
44:neutral point of view
967:American biochemists
451:10.1083/jcb.42.1.296
852:2015Natur.521...15C
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694:Biophysical Journal
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641:(24): 13770–13773.
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386:1967Sci...158..655D
340:nanopore sequencing
332:nanopore sequencing
319:nanopore sequencing
299:electron microscopy
273:, during and after
255:Murchison meteorite
240:David Wilson Deamer
228:nanopore sequencing
141:Academic background
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350:Other publications
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110:Nationality
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359:References
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261:Early life
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56:April 2019
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307:liposomes
146:Education
121:Biologist
48:talk page
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346:method.
324:nanopore
293:Research
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