Knowledge (XXG)

Decay-accelerating factor

Source πŸ“

386: 363: 2310: 260: 285: 2280: 2265: 2250: 2235: 2220: 2205: 2190: 2175: 644: 637: 392: 291: 29: 2295: 2160: 2145: 2130: 2115: 1307:, and interaction of DAF with C3b of the alternative pathway interferes with the conversion of factor B to Bb by factor D, thereby preventing formation of the C3bBb C3 convertase of the alternative pathway. Thus, by limiting the amplification convertases of the complement cascade, DAF indirectly blocks the formation of the 55: 2309: 3638: 1891:"Baculovirus GP64-pseudotyped HIV-based lentivirus vectors are stabilized against complement inactivation by codisplay of decay accelerating factor (DAF) or of a GP64-DAF fusion protein" 1421:
DAF. Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF. and DAF-Fc has yet to be tested in humans.
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Marschang P, Sodroski J, WΓΌrzner R, Dierich MP (January 1995). "Decay-accelerating factor (CD55) protects human immunodeficiency virus type 1 from inactivation by human complement".
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pathway). Interaction of DAF with cell-associated C4b of the classical and lectin pathways interferes with the conversion of C2 to C2b, thereby preventing formation of the C4b2a
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has been tested in mice as an anti-enterovirus therapy for heart damage; however, the human enterovirus that was tested binds much more strongly to human DAF than to
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Selinka HC, Wolde A, Sauter M, et al. (2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism".
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Binding of DAF to human HIV-1 when the virons are budding from the surface of infected cells protects HIV-1 from complement mediated lysis.
4802: 3707: 3633: 2763: 1799:"Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF" 1758:"Coxsackievirus B3-associated myocardial pathology and viral load reduced by recombinant soluble human decay-accelerating factor in mice" 4736: 4731: 4726: 4721: 3648: 2318:: COMPLEX OF ECHOVIRUS TYPE 12 WITH DOMAINS 3 AND 4 OF ITS RECEPTOR DECAY ACCELERATING FACTOR (CD55) BY CRYO ELECTRON MICROSCOPY AT 16 A 1378: 1199: 385: 2564: 1206: 4701: 362: 3937: 2034: 1756:
Yanagawa B, Spiller OB, Choy J, Luo H, Cheung P, Zhang HM, Goodfellow IG, Evans DJ, Suarez A, Yang D, McManus BM (January 2003).
4505: 3999: 3685: 2343: 1487: 1466: 4822: 4144: 3680: 2383: 1410: 1300: 1483: 284: 259: 52: 4812: 4641: 4113: 4108: 4053: 3787: 3236: 1462: 4335: 4058: 2373: 1353: 1292: 201: 1538:"Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement" 3653: 2294: 2159: 2144: 2129: 2114: 1348:(CCP) repeats with a single N-linked glycan positioned between CCP1 and CCP2. CCP2, CCP3, CCP4 and three consecutive 398: 297: 4365: 2790: 2336: 1345: 2087: 1377:-anchored protein, its expression is reduced in persons with mutations that reduce GPI levels such as those with 1374: 1338: 391: 290: 4415: 3310: 2028: 992: 209: 4379: 2699: 2569: 2534: 2529: 2424: 2419: 2414: 1308: 973: 3722: 3717: 3712: 3702: 3009: 2937: 2589: 2579: 2574: 2524: 2503: 2448: 2431: 3066: 2984: 2671: 2666: 2467: 1974:"The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy" 1536:
Medof ME, Lublin DM, Holers VM, Ayers DJ, Getty RR, Leykam JF, Atkinson JP, Tykocinski ML (April 1987).
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residues in a positively charged pocket between CCP2 and CCP3 are involved in its inhibition of the
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surface. It recognizes C4b and C3b fragments that are created during activation of C4 (
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Karnauchow TM, Tolson DL, Harrison BA, Altman E, Lublin DM, Dimock K (August 1996).
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and non-hematopoietic cells. It is a determinant for the Cromer blood group system.
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National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Spiller OB, Goodfellow IG, Evans DJ, Almond JW, Morgan BP (January 2000).
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positive regulation of CD4-positive, alpha-beta T cell proliferation
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positive regulation of CD4-positive, alpha-beta T cell activation
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endoplasmic reticulum-Golgi intermediate compartment membrane
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Overview of all the structural information available in the
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Brodbeck WG, Kuttner-Kondo L, Mold C, Medof ME (Sep 2000).
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regulation of lipopolysaccharide-mediated signaling pathway
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positive regulation of cytosolic calcium ion concentration
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endoplasmic reticulum to Golgi vesicle-mediated transport
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Mikesch JH, Schier K, Roetger A, et al. (2007).
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CD4-positive, alpha-beta T cell cytokine production
1479: 1477: 1475: 1458: 1456: 1454: 408: 307: 863:regulation of complement-dependent cytotoxicity 2065:(Complement decay-accelerating factor) at the 2041:Blood Group Antigen Gene Mutation Database at 1484:GRCm38: Ensembl release 89: ENSMUSG00000026401 2771: 2344: 2088: 8: 858:negative regulation of complement activation 1463:GRCh38: Ensembl release 89: ENSG00000196352 2778: 2764: 2756: 2396: 2351: 2337: 2329: 2095: 2081: 2073: 1052: 888: 668: 449: 348: 245: 63: 2795:list of human clusters of differentiation 2027:at the U.S. National Library of Medicine 1999: 1989: 1906: 1814: 1773: 1732: 1683: 1634: 1571: 1561: 1434:List of human clusters of differentiation 1337:that attaches to the cell membrane via a 828:complement activation, classical pathway 2110: 1889:Guibinga GH, Friedmann T (April 2005). 1450: 16:Mammalian protein found in Homo sapiens 18: 727:integral component of plasma membrane 413: 374: 369: 312: 271: 266: 7: 1259:Complement decay-accelerating factor 1379:paroxysmal nocturnal hemoglobinuria 1369:Paroxysmal nocturnal hemoglobinuria 1273:that, in humans, is encoded by the 838:regulation of complement activation 1775:10.1097/01.lab.0000049349.56211.09 1596:"Molecular function for CD55 Gene" 1401:DAF is used as a receptor by some 1164: 1127: 1097: 1028: 1009: 983: 964: 938: 919: 631: 549: 487: 466: 14: 2308: 2293: 2278: 2263: 2248: 2233: 2218: 2203: 2188: 2173: 2158: 2143: 2128: 2113: 1627:10.1046/j.1365-2567.2000.00086.x 1385:with very low levels of DAF and 642: 635: 397: 390: 384: 361: 296: 289: 283: 258: 27: 1725:10.1128/JVI.70.8.5143-5152.1996 772:ficolin-1-rich granule membrane 2303:: HUMAN CD55 DOMAINS 3 & 4 2168:: HUMAN CD55 DOMAINS 3 & 4 2153:: HUMAN CD55 DOMAINS 3 & 4 2138:: HUMAN CD55 DOMAINS 3 & 4 2123:: HUMAN CD55 DOMAINS 3 & 4 752:anchored component of membrane 653:More reference expression data 615:More reference expression data 1: 1318:is broadly distributed among 382: 281: 1542:Proc. Natl. Acad. Sci. U.S.A 1354:alternate complement pathway 4803:Genes on human chromosome 1 2791:clusters of differentiation 1908:10.1016/j.ymthe.2004.12.002 4839: 1676:10.1182/blood-2005-04-1717 1409:. Recombinant soluble DAF- 1346:complement control protein 848:viral entry into host cell 767:secretory granule membrane 2620:Decay-accelerating factor 2108: 2035:Cromer blood group system 2025:Decay-Accelerating+Factor 1949:10.1007/s00430-003-0193-y 1519:"Mouse PubMed Reference:" 1501:"Human PubMed Reference:" 1339:glycophosphatidylinositol 1245: 1240: 1236: 1229: 1213: 1207:Chr 1: 130.32 – 130.35 Mb 1200:Chr 1: 207.32 – 207.39 Mb 1194: 1171: 1134: 1123: 1104: 1079: 1048: 1035: 1031: 1016: 1012: 1003: 990: 986: 971: 967: 958: 945: 941: 926: 922: 913: 898: 891: 887: 871: 671: 667: 650: 634: 625: 612: 561: 552: 523:mucosa of paranasal sinus 499: 490: 460: 452: 448: 431: 418: 381: 360: 351: 347: 330: 317: 280: 257: 248: 244: 199: 196: 186: 179: 174: 71: 66: 49: 44: 39: 35: 26: 21: 2029:Medical Subject Headings 1381:(PNH). In PNH disorder, 853:neutrophil degranulation 1937:Med. Microbiol. Immunol 1309:membrane attack complex 686:virus receptor activity 531:upper lobe of left lung 1860:10.1002/eji.1830250147 1563:10.1073/pnas.84.7.2007 843:innate immune response 4823:Blood antigen systems 793:immune system process 757:extracellular exosome 507:palpebral conjunctiva 4813:Transfusion medicine 2659:Complement receptors 737:extracellular region 415:1 E4|1 56.89 cM 376:Chromosome 1 (mouse) 274:Chromosome 1 (human) 67:List of PDB id codes 40:Available structures 1991:10.1155/2006/814816 1554:1987PNAS...84.2007M 1397:Infectious diseases 573:seminiferous tubule 2488:Factor P/Properdin 2393:Activators/enzymes 1344:DAF contains four 1283:DAF regulates the 993:ENSMUSG00000026401 781:Biological process 705:Cellular component 679:Molecular function 527:upper lobe of lung 511:lower lobe of lung 4790: 4789: 2753: 2752: 2600: 2599: 2360:Complement system 2326: 2325: 1373:Because DAF is a 1358:classical pathway 1285:complement system 1256: 1255: 1252: 1251: 1225: 1224: 1190: 1189: 1161: 1160: 1119: 1118: 1094: 1093: 1044: 1043: 1025: 1024: 999: 998: 980: 979: 954: 953: 935: 934: 883: 882: 808:respiratory burst 732:transport vesicle 663: 662: 659: 658: 621: 620: 608: 607: 546: 545: 444: 443: 343: 342: 170: 169: 166: 165: 50:Ortholog search: 4830: 2780: 2773: 2766: 2757: 2734:immune adherence 2397: 2353: 2346: 2339: 2330: 2312: 2297: 2282: 2267: 2252: 2237: 2222: 2207: 2192: 2177: 2162: 2147: 2132: 2117: 2097: 2090: 2083: 2074: 2013: 2003: 1993: 1968: 1921: 1920: 1910: 1886: 1880: 1879: 1843: 1837: 1836: 1818: 1794: 1788: 1787: 1777: 1753: 1747: 1746: 1736: 1704: 1698: 1697: 1687: 1670:(12): 3699–709. 1655: 1649: 1648: 1638: 1606: 1600: 1599: 1592: 1586: 1585: 1575: 1565: 1533: 1527: 1526: 1515: 1509: 1508: 1497: 1491: 1481: 1470: 1460: 1403:coxsackieviruses 1335:membrane protein 1299:pathway) or C3 ( 1261:, also known as 1238: 1237: 1209: 1202: 1185: 1165: 1156: 1128: 1124:RefSeq (protein) 1114: 1098: 1089: 1053: 1029: 1010: 984: 965: 939: 920: 889: 669: 655: 646: 639: 632: 617: 585:secondary oocyte 557: 555:Top expressed in 550: 519:nasal epithelium 495: 493:Top expressed in 488: 467: 450: 440: 427: 416: 401: 394: 388: 377: 365: 349: 339: 326: 315: 300: 293: 287: 276: 262: 246: 240: 238:CD55 - orthologs 191: 184: 161: 64: 58: 37: 36: 31: 19: 4838: 4837: 4833: 4832: 4831: 4829: 4828: 4827: 4793: 4792: 4791: 4786: 4590: 4384: 4133: 3817: 3540: 3200: 2798: 2784: 2754: 2749: 2716: 2653: 2596: 2553: 2492: 2388: 2362: 2357: 2327: 2322: 2319: 2313: 2304: 2298: 2289: 2283: 2274: 2268: 2259: 2253: 2244: 2238: 2229: 2223: 2214: 2208: 2199: 2193: 2184: 2178: 2169: 2163: 2154: 2148: 2139: 2133: 2124: 2118: 2104: 2101: 2021: 2016: 1984:(5–6): 223–32. 1971: 1943:(2–3): 127–31. 1934: 1930: 1928:Further reading 1925: 1924: 1888: 1887: 1883: 1845: 1844: 1840: 1796: 1795: 1791: 1755: 1754: 1750: 1706: 1705: 1701: 1657: 1656: 1652: 1608: 1607: 1603: 1594: 1593: 1589: 1535: 1534: 1530: 1517: 1516: 1512: 1499: 1498: 1494: 1482: 1473: 1461: 1452: 1447: 1430: 1399: 1383:red blood cells 1371: 1366: 1328: 1247:View/Edit Mouse 1242:View/Edit Human 1205: 1198: 1195:Location (UCSC) 1181: 1177: 1173: 1152: 1148: 1144: 1140: 1136: 1110: 1106: 1085: 1081: 1075: 1071: 1067: 1063: 1059: 974:ENSG00000196352 867: 776: 722:plasma membrane 700: 691:protein binding 651: 641: 640: 613: 604: 599: 595: 591: 587: 583: 579: 575: 571: 567: 553: 542: 537: 533: 529: 525: 521: 517: 513: 509: 505: 491: 435: 422: 414: 404: 403: 402: 395: 375: 352:Gene location ( 334: 321: 313: 303: 302: 301: 294: 272: 249:Gene location ( 200: 187: 180: 73: 51: 17: 12: 11: 5: 4836: 4834: 4826: 4825: 4820: 4815: 4810: 4805: 4795: 4794: 4788: 4787: 4785: 4784: 4779: 4774: 4769: 4764: 4759: 4754: 4749: 4744: 4739: 4734: 4729: 4724: 4719: 4714: 4709: 4704: 4699: 4694: 4689: 4684: 4679: 4674: 4669: 4664: 4659: 4654: 4649: 4644: 4639: 4634: 4629: 4624: 4619: 4614: 4609: 4604: 4598: 4596: 4592: 4591: 4589: 4588: 4583: 4578: 4573: 4568: 4563: 4558: 4553: 4548: 4543: 4538: 4533: 4528: 4523: 4518: 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2245: 2239: 2232: 2230: 2224: 2217: 2215: 2209: 2202: 2200: 2194: 2187: 2185: 2179: 2172: 2170: 2164: 2157: 2155: 2149: 2142: 2140: 2134: 2127: 2125: 2119: 2112: 2109: 2106: 2105: 2102: 2100: 2099: 2092: 2085: 2077: 2071: 2070: 2049: 2032: 2020: 2019:External links 2017: 2015: 2014: 1969: 1931: 1929: 1926: 1923: 1922: 1881: 1838: 1816:10.1086/315210 1803:J. Infect. Dis 1789: 1748: 1719:(8): 5143–52. 1699: 1650: 1601: 1587: 1548:(7): 2007–11. 1528: 1510: 1492: 1471: 1449: 1448: 1446: 1443: 1442: 1441: 1436: 1429: 1426: 1398: 1395: 1370: 1367: 1365: 1362: 1341:(GPI) anchor. 1327: 1324: 1254: 1253: 1250: 1249: 1244: 1234: 1233: 1227: 1226: 1223: 1222: 1220: 1218: 1211: 1210: 1203: 1196: 1192: 1191: 1188: 1187: 1169: 1168: 1162: 1159: 1158: 1132: 1131: 1125: 1121: 1120: 1117: 1116: 1102: 1101: 1095: 1092: 1091: 1077: 1076: 1050: 1046: 1045: 1042: 1041: 1033: 1032: 1026: 1023: 1022: 1014: 1013: 1007: 1001: 1000: 997: 996: 988: 987: 981: 978: 977: 969: 968: 962: 956: 955: 952: 951: 943: 942: 936: 933: 932: 924: 923: 917: 911: 910: 905: 900: 896: 895: 885: 884: 881: 880: 869: 868: 866: 865: 860: 855: 850: 845: 840: 835: 830: 825: 820: 815: 810: 805: 800: 795: 790: 784: 782: 778: 777: 775: 774: 769: 764: 759: 754: 749: 744: 739: 734: 729: 724: 719: 717:Golgi membrane 714: 708: 706: 702: 701: 699: 698: 693: 688: 682: 680: 676: 675: 665: 664: 661: 660: 657: 656: 648: 647: 629: 623: 622: 619: 618: 610: 609: 606: 605: 603: 602: 601:primary oocyte 598: 594: 590: 586: 582: 578: 574: 570: 566: 562: 559: 558: 547: 544: 543: 541: 540: 539:synovial joint 536: 532: 528: 524: 520: 516: 512: 508: 504: 500: 497: 496: 484: 483: 475: 464: 458: 457: 454:RNA expression 446: 445: 442: 441: 433: 429: 428: 420: 417: 412: 406: 405: 396: 389: 383: 379: 378: 373: 367: 366: 358: 357: 345: 344: 341: 340: 332: 328: 327: 319: 316: 311: 305: 304: 295: 288: 282: 278: 277: 270: 264: 263: 255: 254: 242: 241: 198: 194: 193: 185: 177: 176: 172: 171: 168: 167: 164: 163: 69: 68: 60: 59: 48: 42: 41: 33: 32: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 4835: 4824: 4821: 4819: 4816: 4814: 4811: 4809: 4806: 4804: 4801: 4800: 4798: 4783: 4780: 4778: 4775: 4773: 4770: 4768: 4765: 4763: 4760: 4758: 4755: 4753: 4750: 4748: 4745: 4743: 4740: 4738: 4735: 4733: 4730: 4728: 4725: 4723: 4720: 4718: 4715: 4713: 4710: 4708: 4705: 4703: 4700: 4698: 4695: 4693: 4690: 4688: 4685: 4683: 4680: 4678: 4675: 4673: 4670: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4648: 4645: 4643: 4640: 4638: 4635: 4633: 4630: 4628: 4625: 4623: 4620: 4618: 4615: 4613: 4610: 4608: 4605: 4603: 4600: 4599: 4597: 4593: 4587: 4584: 4582: 4579: 4577: 4574: 4572: 4569: 4567: 4564: 4562: 4559: 4557: 4554: 4552: 4549: 4547: 4544: 4542: 4539: 4537: 4534: 4532: 4529: 4527: 4524: 4522: 4519: 4517: 4514: 4512: 4509: 4507: 4504: 4502: 4499: 4497: 4494: 4492: 4489: 4487: 4484: 4482: 4479: 4477: 4474: 4472: 4469: 4467: 4464: 4462: 4459: 4457: 4454: 4452: 4449: 4447: 4444: 4442: 4439: 4437: 4434: 4432: 4429: 4427: 4424: 4422: 4419: 4417: 4414: 4412: 4409: 4407: 4404: 4402: 4399: 4397: 4394: 4393: 4391: 4387: 4381: 4378: 4376: 4372: 4369: 4367: 4364: 4362: 4359: 4357: 4354: 4352: 4349: 4347: 4344: 4342: 4339: 4337: 4334: 4332: 4329: 4327: 4324: 4320: 4317: 4315: 4312: 4311: 4310: 4307: 4305: 4302: 4300: 4297: 4295: 4292: 4290: 4287: 4285: 4282: 4280: 4277: 4275: 4272: 4270: 4267: 4265: 4262: 4260: 4257: 4255: 4252: 4250: 4247: 4245: 4242: 4239: 4236: 4234: 4230: 4227: 4225: 4222: 4218: 4215: 4213: 4210: 4209: 4208: 4205: 4203: 4200: 4196: 4193: 4191: 4188: 4187: 4186: 4183: 4181: 4178: 4176: 4173: 4171: 4168: 4166: 4163: 4161: 4158: 4156: 4153: 4151: 4148: 4146: 4143: 4142: 4140: 4136: 4130: 4127: 4125: 4122: 4120: 4117: 4115: 4112: 4110: 4107: 4105: 4102: 4100: 4097: 4095: 4092: 4090: 4087: 4085: 4082: 4080: 4077: 4075: 4072: 4070: 4067: 4065: 4062: 4060: 4057: 4055: 4052: 4050: 4047: 4043: 4040: 4038: 4035: 4034: 4033: 4030: 4028: 4025: 4023: 4020: 4018: 4015: 4011: 4008: 4006: 4003: 4001: 3998: 3997: 3996: 3993: 3991: 3988: 3986: 3983: 3981: 3978: 3976: 3973: 3969: 3966: 3964: 3961: 3960: 3959: 3956: 3954: 3951: 3949: 3946: 3944: 3941: 3939: 3936: 3934: 3931: 3929: 3926: 3922: 3919: 3917: 3914: 3913: 3912: 3909: 3906: 3903: 3901: 3898: 3896: 3893: 3891: 3888: 3886: 3882: 3879: 3877: 3874: 3870: 3867: 3865: 3862: 3860: 3857: 3856: 3855: 3852: 3850: 3847: 3845: 3842: 3840: 3837: 3835: 3832: 3830: 3827: 3826: 3824: 3820: 3814: 3811: 3809: 3806: 3804: 3801: 3799: 3796: 3794: 3791: 3789: 3786: 3784: 3781: 3779: 3776: 3774: 3771: 3769: 3766: 3764: 3761: 3759: 3756: 3754: 3751: 3749: 3746: 3744: 3741: 3739: 3736: 3734: 3731: 3729: 3726: 3724: 3721: 3719: 3716: 3714: 3711: 3709: 3706: 3704: 3701: 3699: 3696: 3694: 3691: 3687: 3684: 3682: 3679: 3678: 3677: 3674: 3670: 3667: 3665: 3662: 3661: 3660: 3657: 3655: 3652: 3650: 3647: 3645: 3642: 3640: 3637: 3635: 3632: 3630: 3627: 3625: 3622: 3620: 3617: 3615: 3612: 3610: 3607: 3605: 3602: 3600: 3597: 3593: 3590: 3588: 3585: 3584: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3553: 3550: 3549: 3547: 3543: 3537: 3534: 3532: 3529: 3527: 3524: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3502: 3499: 3497: 3493: 3490: 3488: 3485: 3483: 3480: 3478: 3475: 3473: 3470: 3468: 3465: 3461: 3458: 3456: 3453: 3451: 3448: 3446: 3443: 3441: 3438: 3436: 3433: 3432: 3431: 3428: 3426: 3423: 3421: 3418: 3416: 3413: 3411: 3408: 3406: 3403: 3399: 3396: 3394: 3391: 3390: 3389: 3386: 3384: 3381: 3379: 3376: 3374: 3371: 3369: 3366: 3364: 3361: 3359: 3356: 3354: 3351: 3349: 3346: 3342: 3339: 3337: 3334: 3332: 3329: 3327: 3324: 3322: 3319: 3317: 3314: 3313: 3312: 3309: 3305: 3302: 3300: 3297: 3295: 3292: 3291: 3290: 3287: 3285: 3282: 3278: 3275: 3273: 3270: 3268: 3265: 3264: 3263: 3260: 3258: 3255: 3253: 3250: 3248: 3245: 3243: 3240: 3238: 3235: 3233: 3230: 3228: 3225: 3223: 3220: 3218: 3215: 3213: 3210: 3209: 3207: 3203: 3197: 3194: 3190: 3187: 3185: 3182: 3180: 3177: 3175: 3172: 3170: 3167: 3165: 3162: 3161: 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3135: 3132: 3130: 3127: 3123: 3120: 3118: 3115: 3113: 3110: 3108: 3105: 3104: 3103: 3100: 3098: 3095: 3093: 3090: 3088: 3085: 3083: 3080: 3078: 3075: 3073: 3070: 3068: 3065: 3063: 3060: 3058: 3055: 3051: 3048: 3046: 3043: 3042: 3041: 3038: 3036: 3033: 3031: 3028: 3026: 3023: 3021: 3018: 3016: 3013: 3011: 3008: 3006: 3003: 3001: 2998: 2996: 2993: 2991: 2988: 2986: 2983: 2981: 2978: 2976: 2973: 2971: 2968: 2964: 2961: 2959: 2956: 2955: 2954: 2951: 2949: 2946: 2944: 2941: 2939: 2936: 2932: 2929: 2927: 2924: 2922: 2919: 2917: 2914: 2913: 2912: 2909: 2907: 2904: 2902: 2899: 2895: 2892: 2891: 2890: 2887: 2885: 2882: 2880: 2877: 2875: 2872: 2870: 2867: 2863: 2860: 2858: 2855: 2853: 2850: 2849: 2848: 2845: 2843: 2840: 2836: 2833: 2831: 2828: 2826: 2823: 2821: 2818: 2816: 2813: 2812: 2811: 2808: 2807: 2805: 2801: 2796: 2792: 2788: 2781: 2776: 2774: 2769: 2767: 2762: 2761: 2758: 2746: 2743: 2741: 2737: 2735: 2732: 2729: 2726: 2725: 2723: 2719: 2711: 2708: 2706: 2703: 2702: 2701: 2700:Anaphylatoxin 2698: 2696: 2692: 2688: 2685: 2683: 2680: 2678: 2675: 2673: 2670: 2668: 2665: 2664: 2662: 2660: 2656: 2650: 2647: 2644: 2643: 2640: 2637: 2634: 2633: 2630: 2627: 2625: 2621: 2618: 2616: 2613: 2610: 2609: 2607: 2603: 2591: 2588: 2586: 2583: 2581: 2578: 2576: 2573: 2571: 2568: 2567: 2566: 2563: 2562: 2560: 2556: 2550: 2549:C5-convertase 2547: 2545: 2544:C3-convertase 2542: 2541: 2536: 2533: 2531: 2528: 2527: 2526: 2523: 2519: 2515: 2512: 2510: 2507: 2506: 2505: 2502: 2501: 2499: 2495: 2489: 2486: 2484: 2481: 2479: 2476: 2473: 2472: 2469: 2466: 2464: 2460: 2457: 2454: 2453: 2450: 2447: 2443: 2440: 2438: 2435: 2434: 2433: 2430: 2426: 2423: 2421: 2418: 2416: 2413: 2412: 2411: 2408: 2405: 2404: 2402: 2398: 2395: 2391: 2385: 2382: 2380: 2377: 2375: 2372: 2371: 2369: 2365: 2361: 2354: 2349: 2347: 2342: 2340: 2335: 2334: 2331: 2317: 2311: 2306: 2302: 2296: 2291: 2287: 2281: 2276: 2272: 2266: 2261: 2257: 2251: 2246: 2242: 2236: 2231: 2227: 2221: 2216: 2212: 2206: 2201: 2197: 2191: 2186: 2182: 2176: 2171: 2167: 2161: 2156: 2152: 2146: 2141: 2137: 2131: 2126: 2122: 2116: 2111: 2107: 2098: 2093: 2091: 2086: 2084: 2079: 2078: 2075: 2068: 2064: 2063: 2058: 2054: 2050: 2048: 2044: 2040: 2036: 2033: 2030: 2026: 2023: 2022: 2018: 2011: 2007: 2002: 1997: 1992: 1987: 1983: 1979: 1975: 1970: 1966: 1962: 1958: 1954: 1950: 1946: 1942: 1938: 1933: 1932: 1927: 1918: 1914: 1909: 1904: 1901:(4): 645–51. 1900: 1896: 1892: 1885: 1882: 1877: 1873: 1869: 1865: 1861: 1857: 1854:(1): 285–90. 1853: 1849: 1848:Eur J Immunol 1842: 1839: 1834: 1830: 1826: 1822: 1817: 1812: 1808: 1804: 1800: 1793: 1790: 1785: 1781: 1776: 1771: 1767: 1763: 1759: 1752: 1749: 1744: 1740: 1735: 1730: 1726: 1722: 1718: 1714: 1710: 1703: 1700: 1695: 1691: 1686: 1681: 1677: 1673: 1669: 1665: 1661: 1654: 1651: 1646: 1642: 1637: 1632: 1628: 1624: 1621:(1): 104–11. 1620: 1616: 1612: 1605: 1602: 1597: 1591: 1588: 1583: 1579: 1574: 1569: 1564: 1559: 1555: 1551: 1547: 1543: 1539: 1532: 1529: 1524: 1520: 1514: 1511: 1506: 1502: 1496: 1493: 1489: 1485: 1480: 1478: 1476: 1472: 1468: 1464: 1459: 1457: 1455: 1451: 1444: 1440: 1437: 1435: 1432: 1431: 1427: 1425: 1422: 1420: 1416: 1412: 1408: 1407:enteroviruses 1404: 1396: 1394: 1392: 1388: 1384: 1380: 1376: 1368: 1363: 1361: 1359: 1355: 1351: 1347: 1342: 1340: 1336: 1333: 1325: 1323: 1321: 1320:hematopoietic 1317: 1312: 1310: 1306: 1305:C3-convertase 1302: 1298: 1294: 1290: 1286: 1281: 1279: 1276: 1272: 1268: 1264: 1260: 1248: 1243: 1239: 1235: 1232: 1228: 1221: 1219: 1216: 1212: 1208: 1204: 1201: 1197: 1193: 1186: 1184: 1180: 1176: 1170: 1166: 1163: 1157: 1155: 1151: 1147: 1143: 1139: 1133: 1129: 1126: 1122: 1115: 1113: 1109: 1103: 1099: 1096: 1090: 1088: 1084: 1078: 1074: 1070: 1066: 1062: 1058: 1054: 1051: 1049:RefSeq (mRNA) 1047: 1040: 1039: 1034: 1030: 1027: 1021: 1020: 1015: 1011: 1008: 1006: 1002: 995: 994: 989: 985: 982: 976: 975: 970: 966: 963: 961: 957: 950: 949: 944: 940: 937: 931: 930: 925: 921: 918: 916: 912: 909: 906: 904: 901: 897: 894: 890: 886: 879: 875: 870: 864: 861: 859: 856: 854: 851: 849: 846: 844: 841: 839: 836: 834: 833:viral process 831: 829: 826: 824: 821: 819: 816: 814: 811: 809: 806: 804: 801: 799: 796: 794: 791: 789: 786: 785: 783: 780: 779: 773: 770: 768: 765: 763: 760: 758: 755: 753: 750: 748: 747:membrane raft 745: 743: 740: 738: 735: 733: 730: 728: 725: 723: 720: 718: 715: 713: 710: 709: 707: 704: 703: 697: 696:lipid binding 694: 692: 689: 687: 684: 683: 681: 678: 677: 674: 673:Gene ontology 670: 666: 654: 649: 645: 638: 633: 630: 628: 624: 616: 611: 600: 596: 592: 588: 584: 580: 576: 572: 568: 564: 563: 560: 556: 551: 548: 538: 534: 530: 526: 522: 518: 514: 510: 506: 503:parotid gland 502: 501: 498: 494: 489: 486: 485: 482: 480: 476: 474: 473: 469: 468: 465: 463: 459: 455: 451: 447: 439: 434: 430: 426: 421: 411: 407: 400: 393: 387: 380: 372: 368: 364: 359: 355: 350: 346: 338: 333: 329: 325: 320: 310: 306: 299: 292: 286: 279: 275: 269: 265: 261: 256: 252: 247: 243: 239: 235: 231: 227: 223: 219: 215: 211: 207: 203: 195: 190: 183: 178: 173: 162: 160: 156: 152: 148: 144: 140: 136: 132: 128: 124: 120: 116: 112: 108: 104: 100: 96: 92: 88: 84: 80: 76: 70: 65: 62: 61: 57: 54: 47: 43: 38: 34: 30: 25: 20: 4308: 4228: 4206: 4184: 4031: 3994: 3957: 3910: 3880: 3853: 3675: 3581: 3429: 3231: 3158: 2910: 2745:Opsonization 2740:inflammation 2728:Cytotoxicity 2645: 2635: 2619: 2615:C1-inhibitor 2611: 2474: 2455: 2406: 2315: 2300: 2285: 2270: 2255: 2240: 2225: 2210: 2195: 2180: 2165: 2150: 2135: 2120: 2060: 1981: 1977: 1940: 1936: 1898: 1894: 1884: 1851: 1847: 1841: 1809:(1): 340–3. 1806: 1802: 1792: 1768:(1): 75–85. 1765: 1761: 1751: 1716: 1712: 1702: 1667: 1663: 1653: 1618: 1614: 1604: 1590: 1545: 1541: 1531: 1522: 1513: 1504: 1495: 1423: 1400: 1372: 1343: 1330:DAF is a 70 1329: 1316:glycoprotein 1313: 1282: 1274: 1266: 1262: 1258: 1257: 1183:NP_001391877 1175:NP_001304290 1172: 1154:NP_001287833 1150:NP_001287832 1146:NP_001287831 1142:NP_001108224 1135: 1112:NM_001317361 1105: 1087:NM_001300904 1083:NM_001300903 1080: 1073:NM_001300902 1069:NM_001114752 1065:NM_001114544 1061:NM_001114543 1036: 1017: 991: 972: 946: 927: 907: 902: 742:cell surface 569:spermatocyte 477: 470: 436:130,350,746 423:130,316,274 335:207,386,804 322:207,321,519 197:External IDs 72: 2103:PDB gallery 1978:Cell. Oncol 1762:Lab. Invest 1301:alternative 175:Identifiers 4818:Hematology 4797:Categories 2793:(see also 2605:Inhibitors 1615:Immunology 1490:, May 2017 1469:, May 2017 1445:References 1405:and other 1391:complement 593:blastocyst 515:right lung 481:(ortholog) 218:HomoloGene 2738:Inducing 1364:Pathology 1326:Structure 1293:classical 1179:NP_031853 1138:NP_000565 1108:NM_007827 1057:NM_000574 893:Orthologs 565:spermatid 226:GeneCards 2787:Proteins 2730:(by MAC) 2721:Function 2649:Factor H 2629:Factor I 2483:Factor D 2478:Factor B 2367:Pathways 2010:17167176 1965:21083098 1957:12920584 1917:15771967 1895:Mol Ther 1876:31079892 1833:31672193 1825:10608785 1784:12533688 1713:J. Virol 1694:16051736 1645:11012760 1486:– 1465:– 1428:See also 1389:undergo 1231:Wikidata 872:Sources: 712:membrane 4595:301–350 4389:251–300 4341:CD240CE 4138:201–250 3822:151–200 3545:101–150 2067:PDBe-KB 2057:UniProt 2001:4618202 1868:7531147 1743:8764022 1685:1895106 1636:2327052 1582:2436222 1550:Bibcode 1488:Ensembl 1467:Ensembl 1287:on the 1271:protein 1269:, is a 1005:UniProt 960:Ensembl 899:Species 878:QuickGO 597:Hindgut 456:pattern 182:Aliases 4602:CD300A 4561:CDw293 4346:CD240D 4207:CD213a 4185:CDw210 4150:CD202b 4124:CDw199 4119:CDw198 3773:CD140b 3205:51–100 2497:Middle 2062:P08174 2031:(MeSH) 2008:  1998:  1963:  1955:  1915:  1874:  1866:  1831:  1823:  1782:  1741:  1734:190469 1731:  1692:  1682:  1643:  1633:  1580:  1573:304572 1570:  1350:lysine 1297:lectin 1217:search 1215:PubMed 1038:Q61476 1019:P08174 915:Entrez 627:BioGPS 589:embryo 581:zygote 577:rectum 314:1q32.2 214:104849 206:125240 4808:Blood 4782:CD350 4777:CD349 4772:CD344 4767:CD340 4762:CD339 4757:CD338 4752:CD337 4747:CD336 4742:CD335 4737:CD334 4732:CD333 4727:CD332 4722:CD331 4717:CD329 4712:CD328 4707:CD327 4702:CD326 4697:CD325 4692:CD324 4687:CD322 4682:CD321 4677:CD320 4672:CD318 4667:CD317 4662:CD316 4657:CD315 4652:CD314 4647:CD312 4642:CD309 4637:CD307 4632:CD306 4627:CD305 4622:CD304 4617:CD303 4612:CD302 4607:CD301 4586:CD299 4581:CD298 4576:CD297 4571:CD295 4566:CD294 4556:CD292 4551:CD290 4546:CD289 4541:CD288 4536:CD286 4531:CD284 4526:CD283 4521:CD282 4516:CD281 4511:CD280 4506:CD279 4501:CD278 4496:CD276 4491:CD275 4486:CD274 4481:CD273 4476:CD272 4471:CD271 4466:CD269 4461:CD268 4456:CD267 4451:CD266 4446:CD265 4441:CD264 4436:CD263 4431:CD262 4426:CD261 4421:CD258 4416:CD257 4411:CD256 4406:CD254 4401:CD253 4396:CD252 4380:CD249 4375:CD248 4371:CD247 4366:CD246 4361:CD244 4356:CD243 4351:CD241 4336:CD239 4331:CD238 4326:CD236 4309:CD235 4304:CD234 4299:CD233 4294:CD230 4289:CD229 4284:CD228 4279:CD227 4274:CD226 4269:CD225 4264:CD224 4259:CD223 4254:CD222 4249:CD221 4244:CD220 4229:CD218 4224:CD217 4202:CD212 4180:CD209 4175:CD208 4170:CD207 4165:CD206 4160:CD205 4155:CD204 4145:CD201 4129:CD200 4114:CD197 4109:CD196 4104:CD195 4099:CD194 4094:CD193 4089:CD192 4084:CD191 4079:CD186 4074:CD185 4069:CD184 4064:CD183 4059:CD182 4054:CD181 4049:CD180 4032:CD179 4027:CD178 4022:CD177 4017:CD174 3995:CD172 3990:CD171 3985:CD170 3980:CD169 3975:CD168 3958:CD167 3953:CD166 3948:CD164 3943:CD163 3938:CD162 3933:CD161 3928:CD160 3911:CD159 3881:CD158 3876:CD157 3854:CD156 3849:CD155 3844:CD154 3839:CD153 3834:CD152 3829:CD151 3813:CD150 3808:CD148 3803:CD147 3798:CD146 3793:CD144 3788:CD143 3783:CD142 3778:CD141 3768:CD138 3763:CD137 3758:CD136 3753:CD135 3748:CD134 3743:CD133 3738:CD132 3733:CD131 3728:CD130 3723:CD129 3718:CD127 3713:CD126 3708:CD125 3703:CD124 3698:CD123 3693:CD122 3676:CD121 3659:CD120 3654:CD119 3649:CD118 3644:CD117 3639:CD116 3634:CD115 3629:CD114 3624:CD113 3619:CD112 3614:CD111 3609:CD110 3604:CD109 3599:CD108 3582:CD107 3577:CD106 3572:CD105 3567:CD104 3562:CD103 3557:CD102 3552:CD101 3536:CD100 2691:CD11c 2687:CD11b 2463:MASP2 2459:MASP1 2400:Early 2039:BGMUT 1961:S2CID 1872:S2CID 1829:S2CID 1664:Blood 1415:mouse 1314:This 948:13137 908:Mouse 903:Human 874:Amigo 535:blood 479:Mouse 472:Human 419:Start 354:Mouse 318:Start 251:Human 3531:CD99 3526:CD98 3521:CD97 3516:CD96 3511:CD95 3506:CD94 3501:CD93 3496:CD92 3492:CD91 3487:CD90 3482:CD89 3477:CD88 3472:CD87 3467:CD86 3430:CD85 3425:CD84 3420:CD83 3415:CD82 3410:CD81 3405:CD80 3388:CD79 3383:CD78 3378:CD74 3373:CD73 3368:CD72 3363:CD71 3358:CD70 3353:CD69 3348:CD68 3311:CD66 3289:CD64 3284:CD63 3262:CD62 3257:CD61 3252:CD59 3247:CD58 3242:CD57 3237:CD56 3232:CD55 3227:CD54 3222:CD53 3217:CD52 3212:CD51 3196:CD50 3159:CD49 3154:CD48 3149:CD47 3144:CD46 3139:CD45 3134:CD44 3129:CD43 3102:CD42 3097:CD41 3092:CD40 3087:CD39 3082:CD38 3077:CD37 3072:CD36 3067:CD35 3062:CD34 3057:CD33 3040:CD32 3035:CD31 3030:CD30 3025:CD29 3020:CD28 3015:CD27 3010:CD26 3005:CD25 3000:CD24 2995:CD23 2990:CD22 2985:CD21 2980:CD20 2975:CD19 2970:CD18 2953:CD16 2948:CD15 2943:CD14 2938:CD13 2911:CD11 2906:CD10 2803:1–50 2695:CD18 2639:C4BP 2624:CD59 2612:CLA: 2558:Late 2518:iC3b 2316:1upn 2301:1uot 2286:1ok9 2271:1ok3 2256:1ok2 2241:1ok1 2226:1ojy 2211:1ojw 2196:1ojv 2181:1nwv 2166:1h2q 2151:1h2p 2136:1h04 2121:1h03 2055:for 2043:NCBI 2006:PMID 1953:PMID 1913:PMID 1864:PMID 1821:PMID 1780:PMID 1739:PMID 1690:PMID 1641:PMID 1578:PMID 1439:CD59 1387:CD59 1289:cell 1278:gene 1275:CD55 1263:CD55 929:1604 462:Bgee 410:Band 371:Chr. 309:Band 268:Chr. 230:CD55 202:OMIM 189:CD55 159:5FOA 155:3J24 151:3IYP 147:2QZH 143:2QZF 139:2QZD 135:2C8I 131:1UPN 127:1UOT 123:1OK9 119:1OK3 115:1OK2 111:1OK1 107:1OJY 103:1OJW 99:1OJV 95:1NWV 91:1M11 87:1H2Q 83:1H2P 79:1H04 75:1H03 56:RCSB 53:PDBe 22:CD55 2901:CD9 2889:CD8 2884:CD7 2879:CD6 2874:CD5 2869:CD4 2847:CD3 2842:CD2 2815:a-c 2810:CD1 2710:C5a 2705:C3a 2682:CR4 2677:CR3 2672:CR2 2667:CR1 2636:CL: 2570:C5b 2565:MAC 2535:C5b 2530:C5a 2514:C3b 2509:C3a 2468:MBL 2442:C4b 2437:C4a 2425:C1s 2420:C1r 2415:C1q 2053:PDB 2047:NIH 2037:at 1996:PMC 1986:doi 1945:doi 1941:193 1903:doi 1856:doi 1811:doi 1807:181 1770:doi 1729:PMC 1721:doi 1680:PMC 1672:doi 1668:106 1631:PMC 1623:doi 1619:101 1568:PMC 1558:doi 1419:rat 1417:or 1375:GPI 1332:kDa 1295:or 1267:DAF 1265:or 432:End 331:End 234:OMA 222:479 210:MGI 46:PDB 4799:: 4373:- 3494:- 2835:1E 2830:1D 2825:1B 2820:1A 2789:: 2646:A: 2590:C9 2585:C8 2580:C7 2575:C6 2525:C5 2504:C3 2475:A: 2456:L: 2449:C2 2432:C4 2410:C1 2407:C: 2059:: 2045:, 2004:. 1994:. 1982:28 1980:. 1976:. 1959:. 1951:. 1939:. 1911:. 1899:11 1897:. 1893:. 1870:. 1862:. 1852:25 1850:. 1827:. 1819:. 1805:. 1801:. 1778:. 1766:83 1764:. 1760:. 1737:. 1727:. 1717:70 1715:. 1711:. 1688:. 1678:. 1666:. 1662:. 1639:. 1629:. 1617:. 1613:. 1576:. 1566:. 1556:. 1546:84 1544:. 1540:. 1521:. 1503:. 1474:^ 1453:^ 1411:Fc 1360:. 1311:. 1280:. 876:/ 438:bp 425:bp 337:bp 324:bp 232:; 228:: 224:; 220:: 216:; 212:: 208:; 204:: 157:, 153:, 149:, 145:, 141:, 137:, 133:, 129:, 125:, 121:, 117:, 113:, 109:, 105:, 101:, 97:, 93:, 89:, 85:, 81:, 77:, 4319:b 4314:a 4240:) 4238:b 4233:a 4231:( 4217:2 4212:1 4195:b 4190:a 4042:b 4037:a 4010:g 4005:b 4000:a 3968:b 3963:a 3921:c 3916:a 3907:) 3905:k 3900:i 3895:e 3890:d 3885:a 3883:( 3869:c 3864:b 3859:a 3686:b 3681:a 3669:b 3664:a 3592:b 3587:a 3460:k 3455:j 3450:h 3445:e 3440:d 3435:a 3398:b 3393:a 3341:f 3336:e 3331:d 3326:c 3321:b 3316:a 3304:C 3299:B 3294:A 3277:P 3272:L 3267:E 3189:f 3184:e 3179:d 3174:c 3169:b 3164:a 3122:d 3117:c 3112:b 3107:a 3050:B 3045:A 2963:B 2958:A 2931:d 2926:c 2921:b 2916:a 2894:a 2862:Ξ΅ 2857:Ξ΄ 2852:Ξ³ 2797:) 2779:e 2772:t 2765:v 2693:/ 2689:/ 2622:/ 2516:/ 2461:/ 2384:A 2379:L 2374:C 2352:e 2345:t 2338:v 2096:e 2089:t 2082:v 2069:. 2012:. 1988:: 1967:. 1947:: 1919:. 1905:: 1878:. 1858:: 1835:. 1813:: 1786:. 1772:: 1745:. 1723:: 1696:. 1674:: 1647:. 1625:: 1598:. 1584:. 1560:: 1552:: 1525:. 1507:. 356:) 253:) 236::

Index


PDB
PDBe
RCSB
1H03
1H04
1H2P
1H2Q
1M11
1NWV
1OJV
1OJW
1OJY
1OK1
1OK2
1OK3
1OK9
1UOT
1UPN
2C8I
2QZD
2QZF
2QZH
3IYP
3J24
5FOA
Aliases
CD55
OMIM
125240

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