804:
division-dependent, meaning the cells have to divide in order for the pharmaceutical to act. Therefore, cancer cells which divide much more rapidly than most other cells in the body will be more severely affected by decitabine just because they replicate more. It seems that DNA hypermethylation is critical for development of cancer cells, and specifically for haematological malignancies. Methylation of CpG islands upstream of tumor suppressor genes in order to silence them seems to be critical for these type of cancers. Thus at optimal doses, decitabine blocks this type of methylation and has an anti-
506:
483:
733:
29:
2947:
803:
It incorporates into DNA strands upon replication, and then when DNA methyltransferases (DNMTs) such as DNMT1, are engaged to bind the DNA and to replicate the methylation to the daughter strand, DNMTs are bound to decitabine irreversibly and cannot disengage. Therefore, the action of decitabine is
829:
expression, which leads to genome-wide DNA methylation alterations and global gene expression changes. These studies have revealed several mechanosensitive genes, such as HoxA5, Klf3, and Klf4, whose promoters were hypermethylated by disturbed blood flow, but rescued by DNA methyltransferases
712:) and Intermediate-1, Intermediate-2, and High-Risk International Prognostic Scoring System groups. In patients with chronic kidney disease, Batty and colleagues reported the first case series on the feasibility of therapy with hypomethylating agents in patients with chronic kidney disease.
830:
inhibitors such as 5-aza-2'-deoxycytidine. It has been found that use of this DNA methyltranferase inhibitor prevents atherosclerosis lesion formation and reduces the production of inflammatory
705:
575:
135:
633:
1240:
2987:
59:
1940:
589:
1190:
Moon C, Kim SH, Park KS, Choi BK, Lee HS, Park JB, et al. (June 2009). "Use of epigenetic modification to induce FOXP3 expression in naΓ―ve T cells".
697:
968:
2901:
1233:
701:
2523:
883:
855:
1675:
1631:
1509:
1434:
800:, although decitabine can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains.
772:
609:
3002:
1226:
2972:
2156:
1950:
709:
252:
165:
91:
2997:
2992:
2569:
1571:
1461:
754:
2491:
2474:
2349:
2113:
1491:
2937:
2223:
1819:
382:
2918:
2425:
1218:
750:
462:
110:
692:(MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (
1605:
743:
2781:
2671:
2661:
916:
689:
666:
2828:
2364:
1614:
331:
617:
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
2906:
2813:
2646:
2361:
1847:
1695:
1622:
1041:"Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study"
121:
501:
2726:
2716:
2449:
2291:
716:
670:
451:
221:
1090:"Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia"
1998:
1815:
1785:
1645:
790:
786:
322:
2967:
2396:
2273:
1794:
1710:
231:
2681:
2581:
2560:
2281:
2103:
1935:
1666:
1562:
662:
478:
277:
128:
1039:
Kantarjian H, Issa JP, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, et al. (April 2006).
2977:
1739:
1119:
1070:
677:
2873:
1769:
1749:
1734:
2848:
2437:
1271:
1207:
1168:
1139:"Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis"
1111:
1062:
1021:
826:
693:
431:
191:
179:
41:
2982:
2853:
2625:
2340:
1974:
1959:
1680:
1199:
1158:
1150:
1101:
1088:
Kantarjian HM, O'Brien S, Cortes J, Giles FJ, Faderl S, Issa JP, et al. (August 2003).
1052:
1011:
1003:
911:
518:
371:
213:
391:
2951:
2307:
2269:
2060:
1482:
1397:
822:
286:
992:"Feasibility of therapy with hypomethylating agents in patients with renal insufficiency"
990:
Batty GN, Kantarjian H, Issa JP, Jabbour E, Santos FP, McCue D, et al. (June 2010).
505:
482:
2912:
2461:
2052:
1546:
1410:
1297:
1267:
1254:
1203:
1163:
1138:
1016:
991:
16:
Medication for the treatment of conditions where certain blood cells are dysfunctional,
2961:
2756:
2131:
2004:
1885:
1828:
1586:
1535:
888:
860:
494:
83:
2833:
2797:
2696:
2686:
2640:
2636:
2598:
2506:
2296:
2235:
2231:
2212:
2207:
2186:
2175:
1989:
1983:
1969:
1964:
1895:
1890:
1843:
1729:
1596:
1576:
1505:
1454:
1444:
1258:
1250:
1123:
1074:
940:
311:
148:
143:
69:
2878:
2858:
2843:
2838:
2823:
2786:
2761:
2706:
2676:
2620:
2593:
2466:
2407:
2379:
2369:
2322:
2286:
2202:
2164:
2146:
2141:
2121:
2098:
2069:
2047:
2027:
2017:
1868:
1853:
1833:
1719:
1650:
1636:
1591:
1524:
1519:
1496:
1471:
1439:
1382:
1345:
1322:
1307:
1302:
1287:
835:
797:
732:
77:
1154:
2868:
2776:
2771:
2751:
2746:
2741:
2736:
2731:
2701:
2691:
2656:
2651:
2631:
2586:
2574:
2549:
2544:
2534:
2516:
2511:
2501:
2496:
2454:
2442:
2430:
2402:
2389:
2384:
2354:
2317:
2312:
2250:
2245:
2191:
2136:
2088:
2074:
2022:
2009:
1978:
1911:
1900:
1873:
1863:
1858:
1804:
1759:
1754:
1619:
1551:
1541:
1530:
1514:
1466:
1449:
1425:
1377:
1365:
1317:
551:
362:
669:, a class of conditions where certain blood cells are dysfunctional, and for
2883:
2863:
2818:
2808:
2802:
2721:
2666:
2615:
2539:
2529:
2484:
2471:
2412:
2374:
2302:
2240:
2181:
2170:
2126:
2083:
2042:
2036:
2032:
1994:
1921:
1916:
1906:
1878:
1838:
1799:
1774:
1764:
1724:
1370:
1360:
1355:
1350:
1312:
1007:
63:
1211:
1172:
1115:
1066:
1025:
969:"EC Approves Marketing Authorization Of DACOGEN For Acute Myeloid Leukemia"
20:
2792:
2766:
2711:
2479:
2417:
2197:
2093:
2065:
1744:
1581:
831:
805:
674:
342:
105:
351:
1700:
1601:
1415:
1276:
1106:
1089:
1057:
1040:
757: in this section. Unsourced material may be challenged and removed.
297:
28:
1340:
442:
411:
661:
among others, acts as a nucleic acid synthesis inhibitor. It is a
574:
565:
422:
402:
197:
1222:
185:
100:
726:
821:
A number of investigators have shown a relationship between
467:
174:
640:
706:
refractory anemia with excess blasts in transformation
2935:
2608:
2559:
2339:
2332:
2268:
2222:
2155:
2112:
1949:
1934:
1814:
1784:
1709:
1694:
1665:
1561:
1481:
1424:
1407:
1396:
1332:
1285:
1266:
563:
550:
517:
512:
493:
461:
441:
421:
401:
381:
361:
341:
330:
321:
296:
276:
243:
230:
220:
212:
164:
159:
134:
120:
90:
76:
58:
50:
40:
35:
1143:Arteriosclerosis, Thrombosis, and Vascular Biology
310:
884:"Summary Basis of Decision (SBD) for Demylocan"
825:and disturbed blood flow. This upregulates DNA
285:
1234:
945:National Center for Biotechnology Information
856:"Summary Basis of Decision (SBD) for Dacogen"
8:
109:
19:
205:In general: β (Prescription only)
2336:
1946:
1706:
1421:
1404:
1282:
1241:
1227:
1219:
698:refractory anemia with ringed sideroblasts
504:
481:
370:
264:-erythro-pentofuranosyl)-1,3,5-triazin-2(1
27:
1162:
1105:
1056:
1015:
996:Clinical Lymphoma, Myeloma & Leukemia
773:Learn how and when to remove this message
390:
2988:Drugs developed by Johnson & Johnson
963:
961:
2942:
847:
614:
594:
477:
350:
257:
82:
789:. It hypomethylates DNA by inhibiting
495:
18:
450:
430:
68:
7:
1137:Dunn J, Thabet S, Jo H (July 2015).
796:It functions in a similar manner to
755:adding citations to reliable sources
702:refractory anemia with excess blasts
147:
1510:ribonucleotide reductase inhibitors
410:
301:
1676:Ribonucleotide reductase inhibitor
1632:Ribonucleotide reductase inhibitor
1204:10.1016/j.transproceed.2009.02.101
14:
1435:Dihydrofolate reductase inhibitor
2945:
731:
535:
529:
742:needs additional citations for
710:chronic myelomonocytic leukemia
622:Key:XAUDJQYHKZQPEU-KVQBGUIXSA-N
1572:Thymidylate synthase inhibitor
1462:Thymidylate synthase inhibitor
541:
523:
1:
1492:Adenosine deaminase inhibitor
1333:Block microtubule disassembly
657:), sold under the brand name
597:O=C1/N=C(\N=C/N12O((O)C2)CO)N
715:It also has EU approval for
688:Decitabine is used to treat
1192:Transplantation Proceedings
673:(AML). Chemically, it is a
3019:
1155:10.1161/atvbaha.115.305042
513:Chemical and physical data
2896:
2782:Omacetaxine mepesuccinate
2672:Ciltacabtagene autoleucel
2662:Brexucabtagene autoleucel
917:European Medicines Agency
690:myelodysplastic syndromes
667:myelodysplastic syndromes
630:
605:
585:
248:
26:
2829:Talimogene laherparepvec
1696:Topoisomerase inhibitors
1615:DNA polymerase inhibitor
3003:Hydroxymethyl compounds
2647:Axicabtagene ciloleucel
1251:chemotherapeutic agents
1008:10.3816/CLML.2010.n.032
2973:Pyrimidine antagonists
2814:Sitimagene ceradenovec
2727:Idecabtagene vicleucel
2292:Methyl aminolevulinate
717:acute myeloid leukemia
671:acute myeloid leukemia
655:5-aza-2β²-deoxycytidine
54:5-aza-2'-deoxycytidine
2998:Otsuka Pharmaceutical
2993:Janssen Pharmaceutica
2303:Porphyrin derivatives
1999:Melphalan flufenamide
1646:Hypomethylating agent
1255:antineoplastic agents
791:DNA methyltransferase
787:hypomethylating agent
665:for the treatment of
260:4-Amino-1-(2-deoxy-Ξ²-
2632:Asparagine depleters
2561:Receptor antagonists
2475:+abiraterone acetate
751:improve this article
2682:Denileukin diftitox
2582:Retinoid X receptor
2282:Aminolevulinic acid
2104:Triethylenemelamine
1936:Crosslinking of DNA
1667:Deoxyribonucleotide
1606:+gimeracil/oteracil
23:
2923:Never to phase III
1740:Etirinotecan pegol
1107:10.1002/cncr.11543
1058:10.1002/cncr.21792
46:Dacogen, Demylocan
2933:
2932:
2892:
2891:
2849:Tigilanol tiglate
2341:Enzyme inhibitors
2264:
2263:
2260:
2259:
1960:Nitrogen mustards
1930:
1929:
1690:
1689:
1392:
1391:
892:. 23 October 2014
864:. 23 October 2014
827:methyltransferase
783:
782:
775:
694:refractory anemia
648:
647:
576:Interactive image
463:CompTox Dashboard
263:
201:
189:
177:
103:
3010:
2950:
2949:
2948:
2941:
2854:Tisagenlecleucel
2626:Arsenic trioxide
2337:
2270:Photosensitizers
2061:Alkyl sulfonates
1975:Cyclophosphamide
1947:
1886:Anthracenediones
1707:
1681:Hydroxycarbamide
1422:
1405:
1283:
1243:
1236:
1229:
1220:
1215:
1198:(5): 1848β1854.
1177:
1176:
1166:
1149:(7): 1562β1569.
1134:
1128:
1127:
1109:
1085:
1079:
1078:
1060:
1051:(8): 1794β1803.
1036:
1030:
1029:
1019:
987:
981:
980:
978:
976:
965:
956:
955:
953:
951:
937:
931:
930:
928:
926:
908:
902:
901:
899:
897:
880:
874:
873:
871:
869:
852:
785:Decitabine is a
778:
771:
767:
764:
758:
735:
727:
644:
643:
636:
578:
558:
543:
537:
531:
525:
508:
497:
486:
485:
471:
469:
454:
434:
414:
394:
374:
354:
334:
314:
304:
303:
289:
261:
235:
199:
196:
187:
184:
176:
173:
151:
113:
102:
99:
86:
72:
31:
24:
22:
3018:
3017:
3013:
3012:
3011:
3009:
3008:
3007:
2958:
2957:
2956:
2946:
2944:
2936:
2934:
2929:
2928:
2913:Clinical trials
2888:
2609:Other/ungrouped
2604:
2555:
2328:
2308:Porfimer sodium
2256:
2218:
2151:
2108:
1938:
1926:
1810:
1780:
1698:
1686:
1661:
1557:
1477:
1413:
1411:antimetabolites
1409:
1408:DNA precursors/
1400:
1398:DNA replication
1388:
1328:
1298:Vinca alkaloids
1274:
1262:
1247:
1189:
1186:
1184:Further reading
1181:
1180:
1136:
1135:
1131:
1087:
1086:
1082:
1038:
1037:
1033:
989:
988:
984:
974:
972:
967:
966:
959:
949:
947:
939:
938:
934:
924:
922:
910:
909:
905:
895:
893:
882:
881:
877:
867:
865:
854:
853:
849:
844:
823:atherosclerosis
819:
817:Atherosclerosis
814:
779:
768:
762:
759:
748:
736:
725:
686:
639:
637:
634:(what is this?)
631:
626:
623:
618:
613:
612:
601:
598:
593:
592:
581:
556:
546:
540:
534:
528:
489:
465:
457:
437:
417:
397:
377:
357:
337:
317:
300:
292:
272:
269:
256:
255:
233:
222:Protein binding
214:Pharmacokinetic
208:
155:
123:
116:
17:
12:
11:
5:
3016:
3014:
3006:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2960:
2959:
2955:
2954:
2931:
2930:
2927:
2926:
2925:
2924:
2921:
2910:
2904:
2898:
2897:
2894:
2893:
2890:
2889:
2887:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2800:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2628:
2623:
2618:
2612:
2610:
2606:
2605:
2603:
2602:
2590:
2578:
2565:
2563:
2557:
2556:
2554:
2553:
2547:
2542:
2537:
2532:
2520:
2514:
2509:
2504:
2499:
2488:
2482:
2477:
2469:
2462:PARP inhibitor
2458:
2446:
2434:
2422:
2421:
2420:
2415:
2410:
2405:
2393:
2387:
2382:
2377:
2372:
2358:
2345:
2343:
2334:
2330:
2329:
2327:
2326:
2320:
2315:
2310:
2299:
2294:
2289:
2284:
2278:
2276:
2266:
2265:
2262:
2261:
2258:
2257:
2255:
2254:
2248:
2243:
2238:
2228:
2226:
2220:
2219:
2217:
2216:
2210:
2205:
2194:
2189:
2184:
2179:
2167:
2161:
2159:
2153:
2152:
2150:
2149:
2144:
2139:
2134:
2129:
2124:
2118:
2116:
2114:Platinum-based
2110:
2109:
2107:
2106:
2101:
2096:
2091:
2079:
2078:
2072:
2056:
2055:
2050:
2045:
2040:
2030:
2025:
2013:
2012:
2007:
2002:
1992:
1987:
1981:
1972:
1967:
1955:
1953:
1944:
1932:
1931:
1928:
1927:
1925:
1924:
1919:
1914:
1909:
1904:
1898:
1893:
1882:
1876:
1871:
1866:
1861:
1856:
1851:
1841:
1836:
1829:Anthracyclines
1824:
1822:
1812:
1811:
1809:
1808:
1802:
1790:
1788:
1782:
1781:
1779:
1778:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1715:
1713:
1704:
1692:
1691:
1688:
1687:
1685:
1684:
1671:
1669:
1663:
1662:
1660:
1659:
1653:
1641:
1640:
1627:
1626:
1610:
1609:
1599:
1594:
1589:
1584:
1579:
1567:
1565:
1559:
1558:
1556:
1555:
1549:
1547:Mercaptopurine
1538:
1533:
1528:
1522:
1517:
1501:
1500:
1487:
1485:
1479:
1478:
1476:
1475:
1469:
1458:
1452:
1447:
1442:
1430:
1428:
1419:
1402:
1394:
1393:
1390:
1389:
1387:
1386:
1374:
1368:
1363:
1358:
1353:
1348:
1336:
1334:
1330:
1329:
1327:
1326:
1320:
1315:
1310:
1305:
1293:
1291:
1280:
1264:
1263:
1249:Intracellular
1248:
1246:
1245:
1238:
1231:
1223:
1217:
1216:
1185:
1182:
1179:
1178:
1129:
1100:(3): 522β528.
1080:
1031:
1002:(3): 205β210.
982:
957:
932:
912:"Dacogen EPAR"
903:
875:
846:
845:
843:
840:
818:
815:
813:
810:
781:
780:
739:
737:
730:
724:
721:
685:
682:
646:
645:
628:
627:
625:
624:
621:
619:
616:
608:
607:
606:
603:
602:
600:
599:
596:
588:
587:
586:
583:
582:
580:
579:
571:
569:
561:
560:
554:
548:
547:
544:
538:
532:
526:
521:
515:
514:
510:
509:
499:
491:
490:
488:
487:
474:
472:
459:
458:
456:
455:
447:
445:
439:
438:
436:
435:
427:
425:
419:
418:
416:
415:
407:
405:
399:
398:
396:
395:
387:
385:
379:
378:
376:
375:
367:
365:
359:
358:
356:
355:
347:
345:
339:
338:
336:
335:
327:
325:
319:
318:
316:
315:
307:
305:
294:
293:
291:
290:
282:
280:
274:
273:
271:
270:
259:
251:
250:
249:
246:
245:
241:
240:
237:
228:
227:
224:
218:
217:
210:
209:
207:
206:
203:
194:
182:
170:
168:
162:
161:
157:
156:
154:
153:
140:
138:
132:
131:
126:
124:administration
118:
117:
115:
114:
96:
94:
88:
87:
80:
74:
73:
66:
56:
55:
52:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
3015:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2965:
2963:
2953:
2943:
2939:
2922:
2920:
2917:
2916:
2914:
2911:
2908:
2905:
2903:
2900:
2899:
2895:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2804:
2801:
2799:
2795:
2794:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2757:Lurbinectedin
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2642:
2638:
2634:
2633:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2613:
2611:
2607:
2600:
2596:
2595:
2591:
2588:
2584:
2583:
2579:
2576:
2572:
2571:
2567:
2566:
2564:
2562:
2558:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2527:
2525:
2521:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2494:
2493:
2489:
2486:
2483:
2481:
2478:
2476:
2473:
2470:
2468:
2464:
2463:
2459:
2456:
2452:
2451:
2447:
2444:
2440:
2439:
2435:
2432:
2428:
2427:
2423:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2400:
2399:
2398:
2394:
2391:
2388:
2386:
2383:
2381:
2378:
2376:
2373:
2371:
2367:
2366:
2363:
2359:
2356:
2352:
2351:
2347:
2346:
2344:
2342:
2338:
2335:
2331:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2305:
2304:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2279:
2277:
2275:
2271:
2267:
2252:
2249:
2247:
2244:
2242:
2239:
2237:
2233:
2230:
2229:
2227:
2225:
2224:Intercalation
2221:
2214:
2211:
2209:
2206:
2204:
2200:
2199:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2177:
2173:
2172:
2168:
2166:
2163:
2162:
2160:
2158:
2154:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2132:Dicycloplatin
2130:
2128:
2125:
2123:
2120:
2119:
2117:
2115:
2111:
2105:
2102:
2100:
2097:
2095:
2092:
2090:
2087:
2085:
2081:
2080:
2076:
2073:
2071:
2067:
2064:
2062:
2058:
2057:
2054:
2051:
2049:
2046:
2044:
2041:
2038:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2015:
2014:
2011:
2008:
2006:
2005:Prednimustine
2003:
2000:
1996:
1993:
1991:
1988:
1985:
1982:
1980:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1957:
1956:
1954:
1952:
1948:
1945:
1942:
1937:
1933:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1902:
1899:
1897:
1894:
1892:
1888:
1887:
1883:
1880:
1877:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1849:
1845:
1842:
1840:
1837:
1835:
1831:
1830:
1826:
1825:
1823:
1821:
1820:Intercalation
1817:
1813:
1806:
1803:
1801:
1797:
1796:
1792:
1791:
1789:
1787:
1783:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1722:
1721:
1717:
1716:
1714:
1712:
1708:
1705:
1702:
1697:
1693:
1682:
1678:
1677:
1673:
1672:
1670:
1668:
1664:
1657:
1654:
1652:
1648:
1647:
1643:
1642:
1638:
1634:
1633:
1629:
1628:
1624:
1623:+daunorubicin
1621:
1617:
1616:
1612:
1611:
1607:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1587:Doxifluridine
1585:
1583:
1580:
1578:
1574:
1573:
1569:
1568:
1566:
1564:
1560:
1553:
1550:
1548:
1544:
1543:
1539:
1537:
1536:Rabacfosadine
1534:
1532:
1529:
1526:
1523:
1521:
1518:
1516:
1512:
1511:
1507:
1503:
1502:
1498:
1494:
1493:
1489:
1488:
1486:
1484:
1480:
1473:
1470:
1468:
1464:
1463:
1459:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1437:
1436:
1432:
1431:
1429:
1427:
1423:
1420:
1417:
1412:
1406:
1403:
1399:
1395:
1384:
1380:
1379:
1375:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1343:
1342:
1338:
1337:
1335:
1331:
1324:
1321:
1319:
1316:
1314:
1311:
1309:
1306:
1304:
1300:
1299:
1295:
1294:
1292:
1289:
1284:
1281:
1278:
1273:
1269:
1265:
1260:
1256:
1252:
1244:
1239:
1237:
1232:
1230:
1225:
1224:
1221:
1213:
1209:
1205:
1201:
1197:
1193:
1188:
1187:
1183:
1174:
1170:
1165:
1160:
1156:
1152:
1148:
1144:
1140:
1133:
1130:
1125:
1121:
1117:
1113:
1108:
1103:
1099:
1095:
1091:
1084:
1081:
1076:
1072:
1068:
1064:
1059:
1054:
1050:
1046:
1042:
1035:
1032:
1027:
1023:
1018:
1013:
1009:
1005:
1001:
997:
993:
986:
983:
970:
964:
962:
958:
950:September 24,
946:
942:
936:
933:
921:. 8 June 2006
920:
918:
913:
907:
904:
891:
890:
889:Health Canada
885:
879:
876:
863:
862:
861:Health Canada
857:
851:
848:
841:
839:
837:
833:
828:
824:
816:
811:
809:
807:
801:
799:
794:
792:
788:
777:
774:
766:
763:December 2018
756:
752:
746:
745:
740:This section
738:
734:
729:
728:
722:
720:
718:
713:
711:
707:
703:
699:
695:
691:
683:
681:
679:
676:
672:
668:
664:
660:
656:
652:
642:
635:
629:
620:
615:
611:
604:
595:
591:
584:
577:
573:
572:
570:
567:
562:
555:
553:
549:
522:
520:
516:
511:
507:
503:
500:
498:
496:ECHA InfoCard
492:
484:
480:
479:DTXSID7030432
476:
475:
473:
464:
460:
453:
452:ChEMBL1201129
449:
448:
446:
444:
440:
433:
429:
428:
426:
424:
420:
413:
409:
408:
406:
404:
400:
393:
389:
388:
386:
384:
380:
373:
369:
368:
366:
364:
360:
353:
349:
348:
346:
344:
340:
333:
329:
328:
326:
324:
320:
313:
309:
308:
306:
299:
295:
288:
284:
283:
281:
279:
275:
267:
258:
254:
247:
242:
238:
236:
229:
225:
223:
219:
215:
211:
204:
202: Rx-only
195:
193:
183:
181:
172:
171:
169:
167:
163:
158:
150:
145:
142:
141:
139:
137:
133:
130:
127:
125:
119:
112:
107:
98:
97:
95:
93:
89:
85:
81:
79:
75:
71:
67:
65:
61:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
2834:Tazemetostat
2798:Alitretinoin
2791:
2717:Estramustine
2697:Elsamitrucin
2687:Eflornithine
2641:Pegaspargase
2637:Asparaginase
2630:
2599:Testolactone
2592:
2580:
2568:
2522:
2507:Panobinostat
2490:
2460:
2448:
2436:
2424:
2395:
2360:
2348:
2301:
2297:Padeliporfin
2236:Dactinomycin
2232:Streptomyces
2213:Temozolomide
2208:Mitozolomide
2196:
2187:Mitobronitol
2176:Procarbazine
2169:
2157:Nonclassical
2082:
2059:
2053:Streptozocin
2018:Nitrosoureas
2016:
1990:Chlorambucil
1984:Trofosfamide
1970:Chlormethine
1965:Bendamustine
1958:
1896:Mitoxantrone
1891:Losoxantrone
1884:
1844:Daunorubicin
1827:
1793:
1730:Camptothecin
1718:
1674:
1655:
1644:
1630:
1613:
1597:Fluorouracil
1577:Capecitabine
1570:
1540:
1504:
1490:
1460:
1455:Pralatrexate
1445:Methotrexate
1433:
1376:
1339:
1296:
1195:
1191:
1146:
1142:
1132:
1097:
1093:
1083:
1048:
1044:
1034:
999:
995:
985:
975:28 September
973:. Retrieved
971:. 2012-09-28
948:. Retrieved
944:
941:"Decitabine"
935:
923:. Retrieved
915:
906:
894:. Retrieved
887:
878:
866:. Retrieved
859:
850:
820:
802:
795:
784:
769:
760:
749:Please help
744:verification
741:
723:Pharmacology
714:
687:
684:Medical uses
658:
654:
650:
649:
638:
632:
265:
232:Elimination
166:Legal status
160:Legal status
92:License data
2968:Nucleosides
2909:from market
2879:Vorasidenib
2859:Trabectedin
2844:Tiazofurine
2839:Tebentafusp
2824:Tagraxofusp
2787:Plitidepsin
2762:Mitoguazone
2707:Epacadostat
2677:Demecolcine
2621:Aflibercept
2594:Sex steroid
2467:Fuzuloparib
2408:Carfilzomib
2380:Palbociclib
2370:Abemaciclib
2323:Verteporfin
2287:Efaproxiral
2203:Dacarbazine
2165:Altretamine
2147:Satraplatin
2142:Oxaliplatin
2122:Carboplatin
2099:Triaziquone
2070:Mannosulfan
2048:Ranimustine
2028:Fotemustine
1869:Pirarubicin
1854:Doxorubicin
1848:+cytarabine
1834:Aclarubicin
1795:Podophyllum
1720:Camptotheca
1651:Azacitidine
1637:Gemcitabine
1592:Floxuridine
1525:Fludarabine
1520:Clofarabine
1506:Halogenated
1497:Pentostatin
1472:Raltitrexed
1440:Aminopterin
1383:Ixabepilone
1378:Epothilones
1346:Cabazitaxel
1323:Vinorelbine
1308:Vincristine
1303:Vinblastine
1288:microtubule
836:macrophages
798:azacitidine
559: gΒ·mol
502:100.017.355
432:CHEBI:50131
244:Identifiers
129:Intravenous
78:MedlinePlus
51:Other names
42:Trade names
2962:Categories
2874:Verdinexor
2869:Venetoclax
2777:Oblimersen
2772:Navitoclax
2752:Lucanthone
2747:Lonidamine
2742:Lifileucel
2737:Ivosidenib
2732:Imetelstat
2702:Enasidenib
2692:Elesclomol
2657:Bexarotene
2652:Belzutifan
2587:Bexarotene
2575:Atrasentan
2550:Umbralisib
2545:Idelalisib
2535:Copanlisib
2517:Vorinostat
2512:Romidepsin
2502:Entinostat
2497:Belinostat
2455:Masoprocol
2443:Tiazofurin
2431:Anagrelide
2403:Bortezomib
2390:Seliciclib
2385:Ribociclib
2365:inhibitors
2355:Tipifarnib
2318:Temoporfin
2313:Talaporfin
2251:Plicamycin
2246:Mitomycins
2192:Pipobroman
2171:Hydrazines
2137:Nedaplatin
2089:Carboquone
2084:Aziridines
2075:Treosulfan
2023:Carmustine
2010:Uramustine
1979:Ifosfamide
1951:Alkylating
1912:Bisantrene
1901:Pixantrone
1874:Valrubicin
1864:Idarubicin
1859:Epirubicin
1805:Teniposide
1760:Lurtotecan
1755:Irinotecan
1656:Decitabine
1620:Cytarabine
1563:Pyrimidine
1552:Tioguanine
1542:Thiopurine
1531:Nelarabine
1515:Cladribine
1467:Pemetrexed
1450:Pemetrexed
1426:Folic acid
1366:Paclitaxel
1318:Vinflunine
842:References
806:neoplastic
663:medication
651:Decitabine
564:3D model (
552:Molar mass
392:776B62CQ27
363:ChemSpider
323:IUPHAR/BPS
278:CAS Number
253:IUPAC name
239:30 minutes
111:Decitabine
21:Decitabine
2978:Triazines
2919:Phase III
2907:Withdrawn
2884:Vosaroxin
2864:Veliparib
2819:Sotorasib
2809:Selinexor
2803:Tretinoin
2793:Retinoids
2722:Glasdegib
2667:Celecoxib
2616:Adagrasib
2540:Duvelisib
2530:Alpelisib
2485:Rucaparib
2472:Niraparib
2413:Oprozomib
2375:Alvocidib
2241:Bleomycin
2198:Triazenes
2182:Etoglucid
2127:Cisplatin
2043:Nimustine
2037:Semustine
2033:Lomustine
1995:Melphalan
1922:Menogaril
1917:Crisnatol
1907:Amsacrine
1879:Zorubicin
1839:Amrubicin
1800:Etoposide
1775:Topotecan
1770:Silatecan
1765:Rubitecan
1750:Gimatecan
1735:Cositecan
1725:Belotecan
1401:inhibitor
1371:Tesetaxel
1361:Ortataxel
1356:Larotaxel
1351:Docetaxel
1313:Vindesine
832:cytokines
287:2353-33-5
234:half-life
122:Routes of
70:Monograph
64:Drugs.com
2952:Medicine
2767:Mitotane
2712:Eribulin
2480:Olaparib
2418:Ixazomib
2094:Thiotepa
2066:Busulfan
1745:Exatecan
1582:Carmofur
1290:assembly
1253: /
1212:19545742
1173:25953647
1116:12879469
1067:16532500
1026:20511166
812:Research
808:effect.
675:cytidine
641:(verify)
343:DrugBank
136:ATC code
106:DailyMed
2983:Lactams
1701:S phase
1602:Tegafur
1416:S phase
1341:Taxanes
1277:M phase
1164:4754957
1124:1149318
1075:9556660
1017:3726276
719:(AML).
659:Dacogen
653:(i.e.,
557:228.208
519:Formula
352:DB01262
298:PubChem
178::
152:)
146: (
144:L01BC08
108::
84:a608009
2938:Portal
2902:WHO-EM
2526:(Pi3K)
1483:Purine
1286:Block
1210:
1171:
1161:
1122:
1114:
1094:Cancer
1073:
1065:
1045:Cancer
1024:
1014:
925:4 June
896:29 May
868:29 May
708:, and
678:analog
590:SMILES
443:ChEMBL
412:D03665
372:397844
312:451668
226:<1%
192:β-only
190:
180:β-only
104:
2438:IMPDI
2333:Other
1120:S2CID
1071:S2CID
919:(EMA)
610:InChI
566:JSmol
423:ChEBI
268:)-one
2524:PIKI
2492:HDAC
1941:CCNS
1208:PMID
1169:PMID
1112:PMID
1063:PMID
1022:PMID
977:2012
952:2016
927:2024
898:2022
870:2022
403:KEGG
383:UNII
332:6805
216:data
60:AHFS
2570:ERA
2426:PhI
2397:PrI
2362:CDK
2274:PDT
1272:MIs
1268:SPs
1259:L01
1200:doi
1159:PMC
1151:doi
1102:doi
1053:doi
1049:106
1012:PMC
1004:doi
834:by
753:by
468:EPA
302:CID
149:WHO
2964::
2915::
2450:LI
2350:FI
1816:II
1786:II
1608:))
1206:.
1196:41
1194:.
1167:.
1157:.
1147:35
1145:.
1141:.
1118:.
1110:.
1098:98
1096:.
1092:.
1069:.
1061:.
1047:.
1043:.
1020:.
1010:.
1000:10
998:.
994:.
960:^
943:.
914:.
886:.
858:.
838:.
793:.
704:,
700:,
696:,
680:.
533:12
198:EU
186:US
175:CA
101:US
2940::
2805:)
2796:(
2643:)
2639:/
2635:(
2601:)
2597:(
2589:)
2585:(
2577:)
2573:(
2552:)
2528:(
2519:)
2495:(
2487:)
2465:(
2457:)
2453:(
2445:)
2441:(
2433:)
2429:(
2392:)
2368:(
2357:)
2353:(
2325:)
2306:(
2272:/
2253:)
2234:(
2215:)
2201:(
2178:)
2174:(
2086::
2077:)
2068:(
2063::
2039:)
2035:(
2020::
2001:)
1997:(
1986:)
1977:(
1962::
1943:)
1939:(
1903:)
1889:(
1881:)
1850:)
1846:(
1832:(
1818:+
1807:)
1798:(
1777:)
1723:(
1711:I
1703:)
1699:(
1683:)
1679:(
1658:)
1649:(
1639:)
1635:(
1625:)
1618:(
1604:(
1575:(
1554:)
1545:(
1527:)
1513:(
1508:/
1499:)
1495:(
1474:)
1465:(
1457:)
1438:(
1418:)
1414:(
1385:)
1381:(
1373:)
1344:(
1325:)
1301:(
1279:)
1275:(
1270:/
1261:)
1257:(
1242:e
1235:t
1228:v
1214:.
1202::
1175:.
1153::
1126:.
1104::
1077:.
1055::
1028:.
1006::
979:.
954:.
929:.
900:.
872:.
776:)
770:(
765:)
761:(
747:.
568:)
545:4
542:O
539:4
536:N
530:H
527:8
524:C
470:)
466:(
266:H
262:D
200::
188::
62:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
