456:
433:
785:
31:
771:(EMA) recommended conditional marketing authorization for delamanid in adults with multidrug-resistant pulmonary tuberculosis without other treatment options because of resistance or tolerability. The EMA considered the data show that the benefits of delamanid outweigh the risks, but that additional studies were needed on the long-term effectiveness.
1952:
1352:
531:
890:
The selection and use of essential medicines. Twentieth report of the WHO Expert
Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children)
669:. Use in pregnancy has not been extensively studied, but there have been reports of success and it is currently recommended as part of the standard treatment regimen for pregnant women with
847:
573:
InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
1982:
93:
1887:
819:, which for six months is approximately US$ 900 in low income countries, US$ 3,000 in middle income countries, and US$ 30,000 in high income countries. As of 2016 the
1360:
61:
1141:"Outcomes of Children Born to Pregnant Women With Drug-resistant Tuberculosis Treated With Novel Drugs in Khayelitsha, South Africa: A Report of Five Patients"
1877:
1392:
545:
1110:"Stop TB Partnership | "Stop TB Partnership's Global Drug Facility jumpstarts access to new drugs for MDR-TB with innovative public-private partnerships"
840:
1906:
1058:
1031:
947:
634:
1190:
1474:
1064:
953:
1211:
1892:
1370:
907:
565:
1117:
1972:
1385:
654:
604:
1977:
1882:
226:
123:
1942:
332:
967:
Blair HA, Scott LJ (January 2015). "Delamanid: a review of its use in patients with multidrug-resistant tuberculosis".
1923:
1577:
1378:
650:
600:
412:
1311:
Gler MT, Skripconoka V, Sanchez-Garavito E, Xiao H, Cabrera-Rivero JL, Vargas-Vasquez DE, et al. (June 2012).
1078:
885:
768:
753:
1659:
815:
The medication was not readily available globally as of 2015. It was believed that pricing will be similar to
1911:
1545:
1529:
79:
451:
1637:
1534:
1422:
1405:
169:
401:
1704:
1524:
614:
There are common side effects which include headache, dizziness, and nausea. Other side effects include
641:
had an agreement to get the medication for US$ 1,700 per six month for use in more than 100 countries.
1235:"DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid"
1872:
1550:
1246:
757:
195:
428:
820:
638:
247:
86:
717:. Clinical isolates resistant to this drug tend to have mutations in the biosynthetic pathway for
992:
761:
736:, the drug was used in combination with standard treatments, such as four or five of the drugs
633:
Delamanid was approved for medical use in 2014 in Europe, Japan, and South Korea. It is on the
381:
1409:
1401:
1334:
1274:
1172:
1054:
1048:
1027:
1011:
984:
943:
935:
913:
903:
138:
43:
940:
Side
Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
321:
1324:
1264:
1254:
1191:"Clinical Management of Rifampicin-Resistant Tuberculosis: Updated Clinical Reference Guide"
1162:
1152:
1086:
1019:
976:
893:
468:
256:
161:
1219:
1139:
Acquah R, Mohr-Holland E, Daniels J, Furin J, Loveday M, Mudaly V, et al. (May 2021).
341:
1956:
1700:
1691:
841:"Deltyba (delamanid): Summary of Product Characteristics. 5.2. Pharmacokinetic Properties"
710:
666:
615:
455:
432:
179:
1269:
1250:
1234:
798:
Please help update this article to reflect recent events or newly available information.
665:
Common side effects include headache, dizziness, and nausea. Other side effects include
1917:
1842:
1586:
1436:
1167:
1140:
1109:
733:
627:
1966:
1776:
1763:
1754:
1668:
1614:
718:
693:
Delamanid is activated in the mycobacterium by deazaflavin-dependent nitroreductase (
444:
996:
281:
1814:
1747:
1738:
1725:
1604:
1563:
1558:
1413:
1023:
745:
702:
619:
596:
106:
101:
1353:"European Medicines Agency recommends two new treatment options for tuberculosis"
1157:
1836:
1802:
1768:
1758:
1681:
1645:
1502:
1455:
1293:
816:
1259:
705:
and a highly reactive metabolite. This metabolite attacks the synthesis enzyme
1854:
1830:
1818:
1708:
1487:
1470:
1445:
1233:
Abrahams KA, Batt SM, Gurcha SS, Veerapen N, Bashiri G, Besra GS (June 2023).
980:
749:
737:
714:
507:
312:
238:)-2-Methyl-6-nitro-2--1-piperidinyl}phenoxy)methyl]-2,3-dihydroimidazo oxazole
917:
1825:
1797:
1742:
1734:
1627:
1622:
1599:
1507:
1460:
1450:
1431:
741:
623:
208:
65:
1338:
1278:
1176:
1083:
World Health
Organization model list of essential medicines: 21st list 2019
988:
1329:
1312:
1016:
Tropical
Diseases: An Overview of Major Diseases Occurring in the Americas
22:
1809:
1594:
1492:
764:) were significantly better in patients who additionally took delamanid.
713:, to which mycolic acid would be attached. This mechanism is shared with
685:; therefore strong inducers of this enzyme can reduce its effectiveness.
608:
292:
1091:
898:
301:
71:
1677:
1482:
267:
30:
1497:
682:
670:
392:
187:
823:
had an agreement to get the medication for US$ 1,700 per six month.
361:
1715:
530:
521:
372:
352:
145:
132:
1374:
778:
553:
FC(F)(F)Oc5ccc(OC4CCN(c3ccc(OC2(Oc1nc(cn1C2)()=O)C)cc3)CC4)cc5
417:
1014:. In de Paiva Cavalcanti M, Pereira VR, Dessein AJ (eds.).
1313:"Delamanid for multidrug-resistant pulmonary tuberculosis"
1095:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
635:
1940:
1212:"Delamanid: Neuer Wirkstoff gegen multiresistente TB"
934:
Smith MR, Accinelli A, Tejada FR, Kharel MK (2016).
892:. Geneva: World Health Organization. pp. 30–1.
709:, which is important for the synthesis of cell wall
1865:
1789:
1724:
1690:
1667:
1658:
1636:
1613:
1585:
1576:
1544:
1516:
1469:
1430:
1421:
1010:Alves de Oliverira TS, da Sliva Rabello MC (2017).
519:
506:
467:
462:
443:
411:
391:
371:
351:
331:
311:
291:
266:
246:
217:
207:
194:
178:
168:
160:
122:
117:
92:
78:
60:
52:
42:
37:
1888:Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim
618:. Delamanid works by blocking the manufacture of
280:
255:
1198:Department of Health, Republic of South Africa
1983:World Health Organization essential medicines
1386:
681:Delamanid is metabolised by the liver enzyme
8:
1878:Ethambutol/isoniazid/pyrazinamide/rifampicin
1294:"Neue Wirkstoffe – Bedaquilin und Delamanid"
880:
878:
876:
874:
872:
870:
868:
599:. Specifically it is used, along with other
21:
1018:. Bentham Science Publishers. p. 461.
929:
927:
153:In general: ℞ (Prescription only)
1664:
1582:
1427:
1393:
1379:
1371:
846:. Otsuka Novel Products GmbH. p. 10.
454:
431:
320:
1328:
1268:
1258:
1166:
1156:
1090:
897:
340:
1145:The Pediatric Infectious Disease Journal
1104:
1102:
936:"Drugs Used in Tuberculosis and Leprosy"
1947:
1218:(in German). 9 May 2014. Archived from
832:
570:
550:
427:
300:
231:
1053:. John Wiley & Sons. p. 139.
445:
20:
1085:. Geneva: World Health Organization.
400:
380:
70:
7:
1120:from the original on 16 January 2017
760:. Healing rates (measured as sputum
649:Delamanid is used, along with other
105:
1317:The New England Journal of Medicine
853:from the original on 17 August 2016
360:
271:
1359:. 22 November 2013. Archived from
920:. WHO technical report series;994.
14:
1893:Rifampicin/isoniazid/pyrazinamide
697:), an enzyme which uses dihydro-F
671:rifampicin-resistant tuberculosis
622:thus destabilising the bacterial
1950:
1298:Österreichische Apothekerzeitung
1292:Spreitzer H (18 February 2013).
1067:from the original on 2016-12-20.
956:from the original on 2016-12-20.
783:
655:multidrug-resistant tuberculosis
605:multidrug-resistant tuberculosis
595:, is a medication used to treat
491:
485:
479:
29:
1883:Ethambutol/isoniazid/rifampicin
1012:"Vaccines Against Tuberculosis"
578:Key:XDAOLTSRNUSPPH-XMMPIXPASA-N
1024:10.2174/9781681085876117010022
497:
473:
184:in plasma by albumin, in liver
1:
591:is sold under the brand name
1158:10.1097/INF.0000000000003069
651:antituberculosis medications
601:antituberculosis medications
1777:Thioacetazone (amithiozone)
1578:Protein synthesis inhibitor
1999:
1260:10.1038/s41467-023-39300-z
754:aminoglycoside antibiotics
463:Chemical and physical data
1901:
1357:European Medicines Agency
1300:(in German) (4/2013): 22.
1079:World Health Organization
1050:Successful Drug Discovery
981:10.1007/s40265-014-0331-4
942:. Elsevier. p. 284.
886:World Health Organization
792:This section needs to be
769:European Medicines Agency
561:
541:
222:
28:
1660:Cell envelope antibiotic
1546:Topoisomerase inhibitors
1973:Anti-tuberculosis drugs
1638:Polypeptide antibiotics
1530:Calcium aminosalicylate
1216:Pharmazeutische Zeitung
1978:Trifluoromethyl ethers
1535:Sodium aminosalicylate
1423:Nucleic acid inhibitor
1406:tuberculosis treatment
630:class of medications.
1705:arabinosyltransferase
1525:4-Aminosalicylic acid
1330:10.1056/NEJMoa1112433
1239:Nature Communications
1222:on 24 September 2015.
701:(reduced form), into
213:not excreted in urine
1873:Ethambutol/isoniazid
190:(to a lesser extent)
1741:synth. inhibition:
1363:on 3 December 2013.
1251:2023NatCo..14.3828A
938:. In Ray SD (ed.).
821:Stop TB Partnership
775:Society and culture
689:Mechanism of action
639:Stop TB Partnership
141:(Prescription only)
72:UK Drug Information
25:
1928:Never to phase III
1410:leprostatic agents
1402:Antimycobacterials
1047:Fischer J (2016).
762:culture conversion
1938:
1937:
1785:
1784:
1775:Others/unsorted:
1654:
1653:
1572:
1571:
1323:(23): 2151–2160.
1200:. September 2023.
1060:978-3-527-34115-3
1033:978-1-68108-587-6
949:978-0-444-63889-2
813:
812:
673:in South Africa.
637:. As of 2016 the
586:
585:
532:Interactive image
413:CompTox Dashboard
149:
136:
16:Chemical compound
1990:
1955:
1954:
1953:
1946:
1665:
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1223:
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1202:
1201:
1195:
1187:
1181:
1180:
1170:
1160:
1151:(5): e191–e192.
1136:
1130:
1129:
1127:
1125:
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1097:
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134:
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109:
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33:
26:
24:
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1951:
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1941:
1939:
1934:
1933:
1918:Clinical trials
1897:
1861:
1781:
1720:
1701:Ethylenediamine
1692:Arabinogalactan
1686:
1650:
1632:
1609:
1587:Aminoglycosides
1568:
1549:
1540:
1512:
1465:
1435:
1417:
1399:
1369:
1368:
1351:
1350:
1346:
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1305:
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800:
797:
788:
784:
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734:clinical trials
730:
722:
711:arabinogalactan
700:
691:
679:
667:QT prolongation
663:
661:Adverse effects
647:
626:. It is in the
616:QT prolongation
582:
579:
574:
569:
568:
557:
554:
549:
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537:
512:
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387:
367:
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327:
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270:
262:
242:
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230:
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197:
185:
170:Protein binding
162:Pharmacokinetic
156:
113:
81:
17:
12:
11:
5:
1996:
1994:
1986:
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1843:Nitroimidazole
1839:
1834:
1822:
1806:
1793:
1791:
1787:
1786:
1783:
1782:
1780:
1779:
1772:
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1755:Thiocarbamides
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1479:
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1463:
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1437:RNA polymerase
1425:
1419:
1418:
1400:
1398:
1397:
1390:
1383:
1375:
1367:
1366:
1344:
1303:
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1203:
1182:
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1114:www.stoptb.org
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1002:
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729:
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720:
698:
690:
687:
678:
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662:
659:
646:
643:
628:nitroimidazole
607:. It is taken
584:
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572:
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429:DTXSID60218326
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142:
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119:
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98:
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90:
89:
84:
82:administration
76:
75:
68:
58:
57:
54:
50:
49:
46:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
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1984:
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1958:
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1927:
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1900:
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1823:
1820:
1816:
1812:
1811:
1807:
1804:
1800:
1799:
1795:
1794:
1792:
1790:Other/unknown
1788:
1778:
1774:
1773:
1770:
1767:
1765:
1764:Prothionamide
1762:
1760:
1756:
1753:
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1749:
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1669:Peptidoglycan
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1178:
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620:mycolic acids
617:
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38:Clinical data
36:
32:
27:
19:
1866:Combinations
1853:
1848:
1847:
1841:
1824:
1815:Pyrazinamide
1808:
1796:
1748:Methaniazide
1739:mycolic acid
1726:Mycolic acid
1605:Streptomycin
1564:Moxifloxacin
1559:Gatifloxacin
1523:
1404:, including
1361:the original
1356:
1347:
1320:
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1228:
1220:the original
1215:
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1113:
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814:
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766:
746:pyrazinamide
732:In phase II
731:
706:
703:nitric oxide
694:
692:
680:
677:Interactions
664:
648:
645:Medical uses
632:
613:
597:tuberculosis
592:
588:
587:
402:ChEMBL218650
382:CHEBI:134742
235:
196:Elimination
124:Legal status
118:Legal status
18:
1914:from market
1837:Bedaquiline
1803:Clofazimine
1769:Thiocarlide
1759:Ethionamide
1707:inhibitor:
1682:Cycloserine
1646:Capreomycin
1615:Oxazolidone
1503:Solasulfone
1471:Antifolates
1456:Rifapentine
1245:(1): 3828.
817:bedaquiline
515: g·mol
452:100.348.783
257:681492-22-8
218:Identifiers
203:30–38 hours
53:Other names
44:Trade names
1967:Categories
1855:Pretomanid
1831:Terizidone
1819:Morinamide
1735:Hydrazides
1709:Ethambutol
1680:analogue:
1551:quinolones
1488:Acedapsone
1446:Rifampicin
1432:Rifamycins
1124:15 January
827:References
804:March 2020
758:quinolones
750:rifampicin
738:ethambutol
719:Coenzyme F
715:pretomanid
520:3D model (
508:Molar mass
342:8OOT6M1PC7
313:ChemSpider
248:CAS Number
227:IUPAC name
180:Metabolism
1924:Phase III
1912:Withdrawn
1849:Delamanid
1826:Isoxazole
1798:Phenazine
1743:Isoniazid
1628:Sutezolid
1623:Linezolid
1600:Kanamycin
1508:Sulfoxone
1461:Rifalazil
1451:Rifabutin
1439:inhibitor
918:0512-3054
742:isoniazid
624:cell wall
589:Delamanid
209:Excretion
198:half-life
80:Routes of
66:Drugs.com
56:OPC-67683
23:Delamanid
1957:Medicine
1810:Pyrazine
1595:Amikacin
1493:Diucifon
1339:22670901
1279:37380634
1270:10307805
1177:33847295
1118:Archived
1081:(2019).
1065:Archived
997:34541500
989:25404020
954:Archived
888:(2015).
848:Archived
609:by mouth
293:DrugBank
94:ATC code
87:By mouth
1678:Alanine
1483:Dapsone
1247:Bibcode
1168:8043512
794:updated
728:History
593:Deltyba
513:534.492
469:Formula
322:4981055
302:DB11637
282:6480466
268:PubChem
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1943:Portal
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683:CYP3A4
546:SMILES
393:ChEMBL
362:D09785
188:CYP3A4
174:≥99.5%
137:
1728:layer
1716:SQ109
1694:layer
1671:layer
1194:(PDF)
993:S2CID
969:Drugs
851:(PDF)
844:(PDF)
707:DprE2
566:InChI
522:JSmol
373:ChEBI
1408:and
1335:PMID
1275:PMID
1173:PMID
1126:2017
1055:ISBN
1028:ISBN
985:PMID
944:ISBN
914:ISSN
904:ISBN
859:2016
767:The
353:KEGG
333:UNII
164:data
62:AHFS
1517:ASA
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1325:doi
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1163:PMC
1153:doi
1087:hdl
1020:doi
977:doi
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