793:: to separately sequence the 2 halves of DNA that the foetus inherited from the father and the mother. For the father's half, they searched for DNA sequences present only in the father but not the mother; for the mother's half, they counted the DNA sequences from the mother to deduce the sequences inherited by the foetus, which would be found in excess in the mother's blood plasma. This discovery created a non-invasive method to detect fetal
2243:
Chiu, Rossa W. K.; Akolekar, Ranjit; Zheng, Yama W. L.; Leung, Tak Y.; Sun, Hao; Chan, K. C. Allen; Lun, Fiona M. F.; Go, Attie T. J. I.; Lau, Elizabeth T.; To, William W. K.; Leung, Wing C.; Tang, Rebecca Y. K.; Au-Yeung, Sidney K. C.; Lam, Helena; Kung, Yu Y.; Zhang, Xiuqing; van Vugt, John M. G.;
1418:
2183:
Chiu, Rossa W. K.; Chan, K. C. Allen; Gao, Yuan; Lau, Virginia Y. M.; Zheng, Wenli; Leung, Tak Y.; Foo, Chris H. F.; Xie, Bin; Tsui, Nancy B. Y.; Lun, Fiona M. F.; Zee, Benny C. Y.; Lau, Tze K.; Cantor, Charles R.; Lo, Y. M. Dennis (2008).
2412:
Chan, K. C. Allen; Jiang, Peiyong; Zheng, Yama W. L.; Liao, Gary J. W.; Sun, Hao; Wong, John; Siu, Shing Shun N.; Chan, Wing C.; Chan, Stephen L.; Chan, Anthony T. C.; Lai, Paul B. S.; Chiu, Rossa W. K.; Lo, Y. M. D. (2013).
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in 2001, all at Oxford. He was also a junior research fellow in natural sciences at
Hertford College between 1990 and 1993, and the Wellcome Career Development Fellow in Clinical Medicine from 1993 to 1994.
832:
firm
Decheng Capital, he co-founded Cirina with his longtime CUHK collaborators Rossa Chiu and Allen Chan. The company focuses on cancer detection with circulating tumor DNA. The company was acquired by
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in the mother's blood. This, however, was stymied by a number of factors, including low concentration of fetal cells, high false positive rate and the persistence of fetal cells after giving birth.
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Lo, Y. M. Dennis; Hjelm, N. Magnus; Fidler, Carrie; Sargent, Ian L.; Murphy, Michael F.; Chamberlain, Paul F.; Priscilla M.K., Poon; Christopher W.G., Redman; Wainscoat, James S. (1998).
2682:
2307:
Lo, Y. M. Dennis; Chan, K. C. Allen; Sun, Hao; Chen, Eric Z.; Jiang, Peiyong; Lun, Fiona M. F.; Zheng, Yama W.; Leung, Tak Y.; Lau, Tze K.; Cantor, Charles R.; Chiu, Rossa W. K. (2010).
649:
In 1997, again using the Y chromosome as a marker in mothers bearing baby boys, Lo reported the presence of cell-free fetal DNA in most of the test subjects. This was after he read that
2491:
2415:"Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing"
3389:
584:, at Oxford, and asked to learn the technique from Bell. Working with Kenneth Anthony Fleming, his future PhD advisor, Lo found the relatively new technique generated a lot of
3747:
517:. He selected medicine and decided to study abroad. In 1983, at the age of 20, Lo arrived at Cambridge, where he spent 2 years to complete preclinical medical training and a
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684:(CUHK) in January 1997. In an interview years later, he called this discovery was like "finding your car's engine somewhere other than under the bonnet."
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Lo, Y. M. Dennis; Corbetta, Noemi; Chamberlain, Paul F.; Rai, Vik; Sargent, Ian L.; Redman, Christopher W. G.; Wainscoat, James S. (1997).
1223:
3206:
1920:
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2025:
Severe Acute
Respiratory Syndrome (SARS) Expert Committee (2 October 2003). "The SARS Epidemic: The Prince of Wales Hospital Outbreak".
1870:
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Lun, Fiona M. F.; Chiu, Rossa W. K.; Sun, Kun; Leung, Tak Y.; Jiang, Peiyong; Chan, K. C. Allen; Sun, Hao; Lo, Y. M. Dennis (2013).
1492:
881:
2186:"Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma"
486:
1751:
3035:
2244:
Minekawa, Ryoko; Tang, Mary H. Y.; Wang, Jun; Oudejans, Cees B. M.; Lau, Tze K.; Nicolaides, Kypros H.; Lo, Y. M. Dennis (2011).
1725:
884:, he was one of the 41 voters who held 4 votes and whose voting power would be approximately 7,215 times of an ordinary citizen.
861:
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681:
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2246:"Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study"
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715:. He then sought novel methods to isolate fetal DNA from mother's blood, which in 2002 came in the form of difference in
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2673:"Factwire: 41 privileged voters have 7,200 times greater power than a regular Hong Kong voter following election revamp"
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in 2021. The 3 of them also co-founded Xcelom, which commercialised their research in non-invasive prenatal testing.
35:. In accordance with Hong Kong custom, the Western-style name is Dennis Lo and the Chinese-style name is Lo Yuk-ming.
3306:
2745:
3654:
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777:
450:
of CUHK and the director of the Li Ka Shing
Institute of Health Sciences. His research focuses on the detection of
748:
Lo returned to studying detection of cell-free fetal DNA after the SARS outbreak. In 2008, he reported the use of
3628:
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857:
565:
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2616:
2035:
1974:"Differential DNA Methylation between Fetus and Mother as a Strategy for Detecting Fetal DNA in Maternal Plasma"
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734:, turning the hospital into one of the epicenters in Hong Kong. His group was one of the first to sequence the
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2144:"Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory Syndrome"
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864:. The State Key Laboratory of Translational Oncology at CUHK, with which he is affiliated, is also a
627:
544:
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2365:"Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA"
2309:"Maternal Plasma DNA Sequencing Reveals the Genome-Wide Genetic and Mutational Profile of the Fetus"
2120:
828:
Lo is the co-founder of 2 biotechnology companies, both established in 2014. Using funding from the
3664:
3603:
3211:
1671:
Lo, Y-M. D.; Wainscoat, J. S.; Gillmer, M. D. G.; Patel, P.; Sampietro, M.; Fleming, K. A. (1989).
1302:"Giants in Obstetrics and Gynecology Series: A Profile of Dennis Lo, DM, DPhil, FRCP, FRCPath, FRS"
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using NGS in 2012, when he reported the genetic profiling of cancer in patients' blood plasma.
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Poon, Leo L. M.; Leung, Tse N.; Lau, Tze K.; Chow, Katherine C. K.; Lo, Y. M. Dennis (2002).
3674:
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2781:
2519:"How did 2 Hong Kong innovative pioneers turn ideas into reality that can change the world?"
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than traditional PCR and was a relatively new technology at the time. When used to detect
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712:
585:
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918:
2007 - Award for
Outstanding Contribution for a Publication in the International Journal
2549:"GRAIL and Cirina Combine to Create Global Company Focused on Early Detection of Cancer"
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in a mother bearing a baby boy. During his PhD, Lo wanted to develop his research into
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Lo is married to Alice Siu Ling Wong. They met each other while Lo was pursuing his
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2705:"Schedule 1D Composition of the Technology and Innovation Functional Constituency"
1937:
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2414:
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2285:
1866:"Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma"
1394:
1375:
1063:
Lo is one of the initiators of the Hong Kong
Coalition, co-founded by two former
470:
in 1963. His mother taught music and his father, Wai-hoi Lo, who immigrated from
3569:
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2143:
1884:
1673:"Prenatal sex determination by DNA amplification from maternal peripheral blood"
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722:
Lo's research into non-invasive prenatal testing was interrupted in 2003 by the
439:
206:
3245:(in Chinese). Chinese University of Hong Kong. 19 December 2016. Archived from
2581:"Illumina pushes ahead with closing $ 8bn Grail merger in defiance of EU probe"
1990:
1319:
3579:
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3473:
3453:
2746:"Registration in the Technology and Innovation Functional Constituency ("FC")"
1621:
1201:
753:
692:
1529:
2780:. Registration and Electoral Office, Government of Hong Kong. Archived from
2751:. Registration and Electoral Office, Government of Hong Kong. Archived from
2733:
2210:
1833:"Dennis Lo: 'Should parents be told about a disease their child might get?'"
1582:
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809:
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703:-positive but the mother is Rh-negative. Separately, Lo also detected fetal
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467:
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1999:
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Apart from non-invasive prenatal testing, Lo started investigating cancer
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1754:. Centre for Personalised Medicine, University of Oxford. Archived from
2250:
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782:
696:
26:
2920:
International
Federation of Clinical Chemistry and Laboratory Medicine
2263:
1919:
Poon, Leo L. M.; Leung, Tse N.; Lau, Tze K.; Lo, Y. M. Dennis (2000).
914:
International
Federation of Clinical Chemistry and Laboratory Medicine
912:
2006 - Award for
Significant Contributions in Molecular Diagnostics,
876:) at the same functional constituency. As Lo is also a member of the
790:
254:
2142:
Tsui, Stephen K. W.; Chim, Stephen S. C.; Lo, Y. M. Dennis (2003).
907:
739:
708:
673:
596:
592:
572:
technique for rapidly generating millions of copies of a desired
3354:
2492:"Dennis Lo's three-decade journey to science's greatest prizes"
2856:"Local scientists receive State Science and Technology awards"
704:
573:
576:
sequence. He first heard about the technique at a lecture by
2778:"Election Results: Second Sector, Technology And Innovation"
2832:. Junior Chamber International of Hong Kong. Archived from
2806:. Junior Chamber International of Hong Kong. Archived from
668:
the same year with his wife, as the city was preparing its
1617:"False-positive results and the polymerase chain reaction"
528:
for his clinical training, in part, he claimed, thanks to
2062:"SARS: experience at Prince of Wales Hospital, Hong Kong"
362:
348:
2494:. Croucher Foundation. 22 September 2020. Archived from
3753:
Foreign associates of the
National Academy of Sciences
1522:"Encounters with Alumni from Greater China: Dennis Lo"
973:
2020 - Award for Excellence in Molecular Diagnostics,
3738:
Academic staff of the Chinese University of Hong Kong
3177:"2022 Lasker~DeBakey Clinical Medical Research Award"
1250:"Special Issue: In Memory of the late Dr. Lo Wai-hoi"
801:
could also be determined from mother's blood plasma.
430:, and an important contributor to the development of
1779:"Presence of fetal DNA in maternal plasma and serum"
3637:
3396:
1037:. She is no longer on the faculty list as of 2021.
772:, prompting its introduction into clinics in 2011.
676:. He became a senior lecturer in the Department of
356:
342:
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102:
40:
2643:Hong Kong Science and Technology Parks Corporation
2579:
1615:Lo, Y-M. D.; Mehal, W. Z.; Fleming, K. A. (1988).
1455:(in Chinese). Future Science Prize. Archived from
902:2005 - State Natural Science Award, Second-class,
789:and gave him an idea on how to sequence the fetal
687:One of the first disorders for which Lo developed
521:degree, and studied genetic cloning in his third.
3331:(in Chinese). Hong Kong Coalition. Archived from
819:As of October 2021, Lo is an associate editor of
446:(CUHK), as well as the head of the Department of
261:Genetic analysis of fetal cells in maternal blood
893:2000 - Ten Outstanding Young Person of Hong Kong
2190:Proceedings of the National Academy of Sciences
1561:Proceedings of the National Academy of Sciences
1129:. Hong Kong Academy of Sciences. Archived from
2732:Legislative Council Ordinance (Cap. 542)
993:Lasker-DeBakey Clinical Medical Research Award
214:Lasker-DeBakey Clinical Medical Research Award
3366:
1307:American Journal of Obstetrics and Gynecology
1200:. Embryo Project Encyclopedia. Archived from
764:, this method was later shown to have a 100%
664:Lo, who by the time was married, returned to
318:
304:
8:
2028:SARS in Hong Kong: from Experience to Action
1154:
1152:
1150:
1148:
2950:American Association for Clinical Chemistry
2666:
2664:
926:American Association for Clinical Chemistry
797:. In 2013, his group showed that the fetal
3748:Fellows of the Royal College of Physicians
3373:
3359:
3351:
3215:(in Chinese). 12 June 2011. Archived from
2486:
2484:
1921:"Presence of Fetal RNA in Maternal Plasma"
1480:
1478:
1476:
1474:
1369:
1367:
1365:
1363:
1361:
1359:
1226:. CUHK Faculty of Medicine. Archived from
898:Ten Outstanding Young Persons of the World
738:and to discover the existence of multiple
327:
37:
3305:(in Chinese). 21 May 2021. Archived from
2430:
2380:
2271:
2219:
2209:
2159:
2085:
2060:Tomlinson, Brian; Cockram, Clive (2003).
1989:
1936:
1883:
1591:
1581:
1393:
1327:
1091:
1089:
1087:
1040:It was reported in 2021 that Lo bought a
1025:and the head of the formerly Division of
1011:, where Wong was completing her DPhil in
837:in 2017, which, in turn, was acquired by
726:. An infected patient was treated at the
532:architectural works at Oxford. Lo was at
1191:
1189:
1187:
1185:
1097:"Professor LO Yuk Ming, Dennis, SBS, JP"
707:in mother's blood, which indicated what
419:
1549:
1547:
1486:"Professor Dennis Lo Yuk-ming, SBS, JP"
1083:
3728:Recipients of the Silver Bauhinia Star
3068:. Future Science Prize. Archived from
3066:"2016 The Life Science Prize Laureate"
2111:"Watch this face - Dennis Lo Yuk-ming"
1295:
1293:
1291:
1289:
1287:
1285:
1283:
1281:
1279:
634:). He was also an honorary consultant
564:Lo began his research career studying
286:
3713:Alumni of the University of Cambridge
1728:. Croucher Foundation. Archived from
1376:"Inspiring Minds: Yuk-Ming Dennis Lo"
880:, making him eligible to vote in the
848:, Lo was a registered elector in the
614:After obtaining his PhD, Lo became a
7:
2465:. Clinical Chemistry. Archived from
657:and switched strategy to search for
653:were detectable in cancer patients'
3096:Association for Molecular Pathology
2613:Hong Kong Trade Development Council
2578:Espinoza, Javier (19 August 2021).
2148:The New England Journal of Medicine
2109:Tomlinson, Peta (15 January 2004).
1871:The New England Journal of Medicine
981:Breakthrough Prize in Life Sciences
975:Association for Molecular Pathology
846:2021 Hong Kong legislative election
785:, the flying "H" reminded him of 2
200:Breakthrough Prize in Life Sciences
3723:Alumni of Hertford College, Oxford
2890:Ministry of Science and Technology
2615:. 10 December 2015. Archived from
1254:Hong Kong Journal of Mental Health
1196:Abboud, Alexis (4 November 2014).
904:Ministry of Science and Technology
14:
2517:Cheung, Eric (14 December 2020).
1493:Hong Kong Metropolitan University
482:. He also has a younger brother.
3042:. 2 October 2013. Archived from
2862:. 9 January 2006. Archived from
1831:Corbyn, Zoë (1 September 2013).
775:The next year, while watching a
3718:Alumni of Christ Church, Oxford
2892:. 21 April 2006. Archived from
2555:. 31 March 2017. Archived from
882:Election Committee constituency
878:Election Committee of Hong Kong
752:(NGS), which has a much higher
719:between the mother and foetus.
699:that occurs when the foetus is
682:Chinese University of Hong Kong
595:DNA was detectable in mother's
444:Chinese University of Hong Kong
363:
349:
244:Chinese University of Hong Kong
2314:Science Translational Medicine
1160:"Professor Yuk Ming Dennis Lo"
1033:, Faculty of Education at the
760:, which is caused by an extra
691:using cell-free fetal DNA was
410:
319:
305:
1:
3040:The World Academy of Sciences
2671:FactWire (15 December 2021).
2639:"Revolutionary Prenatal Test"
2078:10.1016/S0140-6736(03)13218-7
1795:10.1016/S0140-6736(97)02174-0
1689:10.1016/s0140-6736(89)91969-7
1635:10.1016/S0140-6736(88)90487-4
1065:Chief Executives of Hong Kong
952:The World Academy of Sciences
689:non-invasive prenatal testing
607:, using fetal DNA from fetal
599:. Using PCR, he detected the
491:primary and secondary schools
442:Professor of Medicine at the
432:non-invasive prenatal testing
423:, born 12 October 1963) is a
159:Non-invasive prenatal testing
16:Hong Kong molecular biologist
3743:Fellows of the Royal Society
3299:"「無創產前檢測之父」2.1億購名鑄 實呎逾7萬創新高"
3036:"Fifty-two new TWAS members"
3010:National Academy of Sciences
2432:10.1373/clinchem.2012.196014
2382:10.1373/clinchem.2013.212274
2327:10.1126/scitranslmed.3001720
1528:China Office. Archived from
1395:10.1373/clinchem.2011.179069
1018:. They got married in 1994.
946:National Academy of Sciences
730:, the teaching hospital for
582:Regius Professor of Medicine
474:to Hong Kong in 1946, was a
2161:10.1056/NEJM200307103490216
1938:10.1093/clinchem/46.11.1832
1885:10.1056/NEJM199812103392402
1374:Misia Landau (April 2012).
94:
3774:
3147:"Royal Medal winners 2021"
2609:"Reassurance without Risk"
1419:"【當科學遇上醫療】一碗即食麵破解 血漿基因的秘密"
1320:10.1016/j.ajog.2018.01.027
750:next-generation sequencing
20:
2830:"Past World TOYP from HK"
2714:, Government of Hong Kong
1554:Viegas, Jennifer (2013).
1260:(1). 2017. Archived from
858:geographical constituency
854:Technology and Innovation
566:polymerase chain reaction
524:In 1986, he moved to the
374:
326:
294:
281:
222:
93:
87:), Founding Member (ASHK)
3271:. Faculty of Education,
2946:"Yuk-Ming Dennis Lo, MD"
2523:South China Morning Post
2116:South China Morning Post
1991:10.1093/clinchem/48.1.35
1300:Romero, Roberto (2018).
1101:CUHK Faculty of Medicine
732:CUHK Faculty of Medicine
728:Prince of Wales Hospital
605:prenatal diagnostic test
547:(during which he was at
462:Early life and education
300:Traditional Chinese
3273:University of Hong Kong
2860:Government of Hong Kong
2804:"Past HK TOYP Awardees"
2211:10.1073/pnas.0810641105
1583:10.1073/pnas.1317868110
1035:University of Hong Kong
1021:As of 2016, Wong is an
850:functional constituency
640:John Radcliffe Hospital
632:Green Templeton College
539:He first completed his
511:University of Cambridge
507:University of Hong Kong
478:and the former head of
314:Simplified Chinese
277:Kenneth Anthony Fleming
144:University of Cambridge
1556:"Profile of Dennis Lo"
1417:蕭, 曉華 (12 June 2017).
868:(an elector that is a
787:homologous chromosomes
588:due to contamination.
503:electrical engineering
79:International Member (
3733:Chemical pathologists
2712:Department of Justice
1752:"Professor Dennis Lo"
814:circulating tumor DNA
651:circulating tumor DNA
620:clinical biochemistry
534:Christ Church College
497:, he was accepted by
3758:Hong Kong scientists
3575:Konstantin Novoselov
3309:on 17 September 2021
3279:on 11 September 2021
3249:on 11 September 2021
3219:on 11 September 2021
3157:on 15 September 2021
3127:on 15 September 2021
3117:"Yuk Ming Dennis Lo"
3072:on 15 September 2021
3046:on 15 September 2021
3016:on 14 September 2021
3006:"Yuk-Ming Dennis Lo"
2986:on 14 September 2021
2956:on 14 September 2021
2926:on 13 September 2021
2896:on 13 September 2021
2866:on 13 September 2021
2836:on 14 September 2021
2678:Hong Kong Free Press
1526:University of Oxford
1459:on 22 September 2021
1344:on 23 September 2021
1264:on 20 September 2021
1230:on 10 September 2021
1198:"Dennis Lo (1963- )"
1127:"Prof Dennis Y M LO"
1009:University of Oxford
968:Future Science Prize
636:chemical pathologist
628:University of Oxford
591:Lo then wondered if
570:molecular biological
543:in 1989, and then a
536:during this period.
526:University of Oxford
480:Castle Peak Hospital
434:. He is the current
248:University of Oxford
131:University of Oxford
3665:Phillip Allen Sharp
3269:"Faculty Academics"
3212:Oriental Daily News
2202:2008PNAS..10520458C
2196:(51): 20458–20463.
2072:(9368): 1486–1487.
1683:(8676): 1363–1365.
1574:2013PNAS..11018742V
1568:(47): 18742–18743.
1453:"卢煜明：与艺术结合的科学更有想象力"
1433:on 26 February 2021
1204:on 8 September 2021
1170:on 8 September 2021
1133:on 8 September 2021
1107:on 8 September 2021
1023:associate professor
661:in mother's blood.
659:cell-free fetal DNA
499:Stanford University
487:St Joseph's College
452:cell-free fetal DNA
428:molecular biologist
180:Alice Siu Ling Wong
167:Cell-free fetal DNA
3521:David Manolopoulos
3335:on 31 January 2022
3121:Breakthrough Prize
2916:"Awards Committee"
2810:on 18 January 2021
2784:on 1 February 2022
2758:on 2 February 2022
2649:on 26 October 2021
2619:on 26 October 2021
2559:on 23 October 2021
2529:on 23 October 2021
2498:on 26 October 2021
2469:on 30 October 2021
2419:Clinical Chemistry
2369:Clinical Chemistry
2288:on 12 October 2021
2123:on 10 October 2021
1978:Clinical Chemistry
1953:on 10 October 2021
1925:Clinical Chemistry
1845:on 17 October 2020
1502:on 5 December 2020
1381:Clinical Chemistry
970:Life Science Prize
921:Clinical Chemistry
888:Honours and awards
872:, as opposed to a
822:Clinical Chemistry
678:Chemical Pathology
530:Christopher Wren's
448:Chemical Pathology
381:Dennis Lo Yuk-ming
42:Dennis Lo Yuk-ming
3690:
3689:
3504:Steffen Lauritzen
3239:"好奇心泛起了漣漪——專訪盧煜明"
3181:Lasker Foundation
3092:"Past Recipients"
2886:"2005年度国家自然科学奖目录"
2858:(Press release).
2685:on 7 January 2022
2551:(Press release).
2463:"Editorial Board"
2375:(11): 1583–1594.
2264:10.1136/bmj.c7401
2006:on 8 October 2021
1931:(11): 1832–1834.
1878:(24): 1734–1738.
1789:(9076): 485–487.
1758:on 6 October 2021
1732:on 6 October 2021
1164:King Faisal Prize
1031:Science Education
958:King Faisal Prize
950:2013 - Fellow of
942:Foreign Associate
866:corporate elector
768:and a nearly 98%
644:teaching hospital
378:
377:
370:
369:
344:Yale Romanization
285:
284:
234:Molecular biology
224:Scientific career
218:
211:
204:
197:
189:King Faisal Prize
120:British Hong Kong
3765:
3675:Thomas A. Steitz
3526:Gerhard Materlik
3499:Robert Kennicutt
3375:
3368:
3361:
3352:
3345:
3344:
3342:
3340:
3325:
3319:
3318:
3316:
3314:
3295:
3289:
3288:
3286:
3284:
3275:. Archived from
3265:
3259:
3258:
3256:
3254:
3235:
3229:
3228:
3226:
3224:
3207:"探射燈：膝下猶虛視科研為兒女"
3203:
3197:
3196:
3194:
3192:
3187:on 20 April 2023
3183:. Archived from
3173:
3167:
3166:
3164:
3162:
3153:. Archived from
3143:
3137:
3136:
3134:
3132:
3123:. Archived from
3113:
3107:
3106:
3104:
3102:
3088:
3082:
3081:
3079:
3077:
3062:
3056:
3055:
3053:
3051:
3032:
3026:
3025:
3023:
3021:
3012:. Archived from
3002:
2996:
2995:
2993:
2991:
2982:. Archived from
2972:
2966:
2965:
2963:
2961:
2952:. Archived from
2942:
2936:
2935:
2933:
2931:
2922:. Archived from
2912:
2906:
2905:
2903:
2901:
2882:
2876:
2875:
2873:
2871:
2852:
2846:
2845:
2843:
2841:
2826:
2820:
2819:
2817:
2815:
2800:
2794:
2793:
2791:
2789:
2774:
2768:
2767:
2765:
2763:
2757:
2750:
2742:
2736:
2730:
2724:
2723:
2721:
2719:
2709:
2701:
2695:
2694:
2692:
2690:
2681:. Archived from
2668:
2659:
2658:
2656:
2654:
2645:. Archived from
2635:
2629:
2628:
2626:
2624:
2605:
2599:
2598:
2596:
2594:
2583:
2575:
2569:
2568:
2566:
2564:
2545:
2539:
2538:
2536:
2534:
2525:. Archived from
2514:
2508:
2507:
2505:
2503:
2488:
2479:
2478:
2476:
2474:
2459:
2453:
2452:
2434:
2409:
2403:
2402:
2384:
2360:
2354:
2353:
2351:
2349:
2304:
2298:
2297:
2295:
2293:
2284:. Archived from
2275:
2240:
2234:
2233:
2223:
2213:
2180:
2174:
2173:
2163:
2139:
2133:
2132:
2130:
2128:
2119:. Archived from
2106:
2100:
2099:
2089:
2057:
2051:
2050:
2048:
2046:
2041:on 13 April 2021
2040:
2034:. Archived from
2033:
2022:
2016:
2015:
2013:
2011:
2002:. Archived from
1993:
1969:
1963:
1962:
1960:
1958:
1949:. Archived from
1940:
1916:
1910:
1909:
1907:
1905:
1896:. Archived from
1887:
1861:
1855:
1854:
1852:
1850:
1841:. Archived from
1828:
1822:
1821:
1819:
1817:
1774:
1768:
1767:
1765:
1763:
1748:
1742:
1741:
1739:
1737:
1722:
1716:
1715:
1713:
1711:
1668:
1662:
1661:
1659:
1657:
1612:
1606:
1605:
1595:
1585:
1551:
1542:
1541:
1539:
1537:
1518:
1512:
1511:
1509:
1507:
1501:
1495:. Archived from
1490:
1482:
1469:
1468:
1466:
1464:
1449:
1443:
1442:
1440:
1438:
1429:. Archived from
1414:
1408:
1407:
1397:
1371:
1354:
1353:
1351:
1349:
1340:. Archived from
1331:
1297:
1274:
1273:
1271:
1269:
1246:
1240:
1239:
1237:
1235:
1220:
1214:
1213:
1211:
1209:
1193:
1180:
1179:
1177:
1175:
1166:. Archived from
1156:
1143:
1142:
1140:
1138:
1123:
1117:
1116:
1114:
1112:
1103:. Archived from
1093:
808:, profiling and
622:and a fellow at
549:Hertford College
495:secondary school
421:
412:
404:
391:
366:
365:
352:
351:
328:
322:
321:
308:
307:
287:
273:Doctoral advisor
267:
216:
209:
202:
195:
116:
113:October 12, 1963
112:
110:
97:
88:
76:
71:
64:
56:
51:
38:
3773:
3772:
3768:
3767:
3766:
3764:
3763:
3762:
3693:
3692:
3691:
3686:
3633:
3489:Colin Humphreys
3479:Janet Hemingway
3449:Nicholas Franks
3429:Doreen Cantrell
3414:Jeremy Baumberg
3409:Andrew Balmford
3392:
3379:
3349:
3348:
3338:
3336:
3327:
3326:
3322:
3312:
3310:
3297:
3296:
3292:
3282:
3280:
3267:
3266:
3262:
3252:
3250:
3243:U-Beat Magazine
3237:
3236:
3232:
3222:
3220:
3205:
3204:
3200:
3190:
3188:
3175:
3174:
3170:
3160:
3158:
3145:
3144:
3140:
3130:
3128:
3115:
3114:
3110:
3100:
3098:
3090:
3089:
3085:
3075:
3073:
3064:
3063:
3059:
3049:
3047:
3034:
3033:
3029:
3019:
3017:
3004:
3003:
2999:
2989:
2987:
2974:
2973:
2969:
2959:
2957:
2944:
2943:
2939:
2929:
2927:
2914:
2913:
2909:
2899:
2897:
2884:
2883:
2879:
2869:
2867:
2854:
2853:
2849:
2839:
2837:
2828:
2827:
2823:
2813:
2811:
2802:
2801:
2797:
2787:
2785:
2776:
2775:
2771:
2761:
2759:
2755:
2748:
2744:
2743:
2739:
2731:
2727:
2717:
2715:
2707:
2703:
2702:
2698:
2688:
2686:
2670:
2669:
2662:
2652:
2650:
2637:
2636:
2632:
2622:
2620:
2607:
2606:
2602:
2592:
2590:
2587:Financial Times
2577:
2576:
2572:
2562:
2560:
2547:
2546:
2542:
2532:
2530:
2516:
2515:
2511:
2501:
2499:
2490:
2489:
2482:
2472:
2470:
2461:
2460:
2456:
2411:
2410:
2406:
2362:
2361:
2357:
2347:
2345:
2306:
2305:
2301:
2291:
2289:
2242:
2241:
2237:
2182:
2181:
2177:
2141:
2140:
2136:
2126:
2124:
2108:
2107:
2103:
2059:
2058:
2054:
2044:
2042:
2038:
2031:
2024:
2023:
2019:
2009:
2007:
1971:
1970:
1966:
1956:
1954:
1918:
1917:
1913:
1903:
1901:
1863:
1862:
1858:
1848:
1846:
1830:
1829:
1825:
1815:
1813:
1776:
1775:
1771:
1761:
1759:
1750:
1749:
1745:
1735:
1733:
1724:
1723:
1719:
1709:
1707:
1670:
1669:
1665:
1655:
1653:
1614:
1613:
1609:
1553:
1552:
1545:
1535:
1533:
1520:
1519:
1515:
1505:
1503:
1499:
1488:
1484:
1483:
1472:
1462:
1460:
1451:
1450:
1446:
1436:
1434:
1423:Ming Pao Weekly
1416:
1415:
1411:
1373:
1372:
1357:
1347:
1345:
1299:
1298:
1277:
1267:
1265:
1248:
1247:
1243:
1233:
1231:
1222:
1221:
1217:
1207:
1205:
1195:
1194:
1183:
1173:
1171:
1158:
1157:
1146:
1136:
1134:
1125:
1124:
1120:
1110:
1108:
1095:
1094:
1085:
1080:
1072:Leung Chun-ying
1060:$ 210 million.
1046:The Masterpiece
1001:
890:
830:venture capital
717:DNA methylation
586:false positives
562:
466:Lo was born in
464:
438:(Research) and
420:Lou4 Juk1 Ming4
392:
383:
265:
246:
212:
205:
198:
165:
161:
142:
122:
117:
114:
108:
106:
98:
95:
89:
78:
69:
62:
58:
49:
45:
43:
36:
17:
12:
11:
5:
3771:
3769:
3761:
3760:
3755:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3695:
3694:
3688:
3687:
3685:
3684:
3681:Edward Stolper
3677:
3672:
3670:Carla J. Shatz
3667:
3662:
3657:
3655:Mikhail Gromov
3652:
3647:
3645:David Chandler
3641:
3639:
3635:
3634:
3632:
3631:
3626:
3621:
3619:Angela Vincent
3616:
3611:
3606:
3601:
3594:
3589:
3582:
3577:
3572:
3567:
3562:
3557:
3550:
3543:
3541:David McMurtry
3538:
3533:
3531:James McKernan
3528:
3523:
3518:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3459:Steven Gamblin
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3404:Robin Allshire
3400:
3398:
3394:
3393:
3380:
3378:
3377:
3370:
3363:
3355:
3347:
3346:
3320:
3290:
3260:
3230:
3198:
3168:
3138:
3108:
3083:
3057:
3027:
2997:
2967:
2937:
2907:
2888:(in Chinese).
2877:
2847:
2821:
2795:
2769:
2737:
2725:
2696:
2660:
2630:
2600:
2570:
2540:
2509:
2480:
2454:
2425:(1): 211–224.
2404:
2355:
2321:(61): 61ra91.
2299:
2235:
2175:
2154:(2): 187–188.
2134:
2101:
2052:
2017:
1964:
1911:
1900:on 25 May 2021
1856:
1823:
1769:
1743:
1717:
1663:
1607:
1543:
1532:on 3 June 2021
1513:
1470:
1444:
1425:(in Chinese).
1409:
1388:(4): 784–786.
1355:
1314:(4): 371–378.
1275:
1241:
1215:
1181:
1144:
1118:
1082:
1081:
1079:
1076:
1000:
997:
996:
995:
989:
983:
977:
971:
964:
954:
948:
938:
928:
916:
910:
900:
894:
889:
886:
874:natural person
561:
558:
551:) in 1994 and
463:
460:
436:Associate Dean
376:
375:
372:
371:
368:
367:
360:
354:
353:
350:Lòuh Yūk Mìhng
346:
340:
339:
337:Yue: Cantonese
333:
332:
331:Transcriptions
324:
323:
316:
310:
309:
302:
296:
295:
292:
291:
283:
282:
279:
278:
275:
269:
268:
257:
251:
250:
241:
237:
236:
231:
227:
226:
220:
219:
186:
182:
181:
178:
174:
173:
156:
155:Known for
152:
151:
128:
124:
123:
118:
104:
100:
99:
91:
90:
44:
41:
23:Hong Kong name
15:
13:
10:
9:
6:
4:
3:
2:
3770:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3708:Living people
3706:
3704:
3701:
3700:
3698:
3683:
3682:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3660:Thomas Hughes
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3642:
3640:
3636:
3630:
3629:Robert Watson
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3599:
3598:Mark Randolph
3595:
3593:
3590:
3588:
3587:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3555:
3554:Arthur Milner
3551:
3549:
3548:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3516:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3494:Alex Kacelnik
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3424:Béla Bollobás
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3401:
3399:
3395:
3391:
3387:
3386:Royal Society
3383:
3376:
3371:
3369:
3364:
3362:
3357:
3356:
3353:
3334:
3330:
3324:
3321:
3308:
3304:
3300:
3294:
3291:
3278:
3274:
3270:
3264:
3261:
3248:
3244:
3240:
3234:
3231:
3218:
3214:
3213:
3208:
3202:
3199:
3186:
3182:
3178:
3172:
3169:
3156:
3152:
3151:Royal Society
3148:
3142:
3139:
3126:
3122:
3118:
3112:
3109:
3097:
3093:
3087:
3084:
3071:
3067:
3061:
3058:
3045:
3041:
3037:
3031:
3028:
3015:
3011:
3007:
3001:
2998:
2985:
2981:
2980:Royal Society
2977:
2971:
2968:
2955:
2951:
2947:
2941:
2938:
2925:
2921:
2917:
2911:
2908:
2895:
2891:
2887:
2881:
2878:
2865:
2861:
2857:
2851:
2848:
2835:
2831:
2825:
2822:
2809:
2805:
2799:
2796:
2783:
2779:
2773:
2770:
2754:
2747:
2741:
2738:
2735:
2729:
2726:
2713:
2706:
2700:
2697:
2684:
2680:
2679:
2674:
2667:
2665:
2661:
2648:
2644:
2640:
2634:
2631:
2618:
2614:
2610:
2604:
2601:
2589:
2588:
2582:
2574:
2571:
2558:
2554:
2550:
2544:
2541:
2528:
2524:
2520:
2513:
2510:
2497:
2493:
2487:
2485:
2481:
2468:
2464:
2458:
2455:
2450:
2446:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2408:
2405:
2400:
2396:
2392:
2388:
2383:
2378:
2374:
2370:
2366:
2359:
2356:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2315:
2310:
2303:
2300:
2287:
2283:
2279:
2274:
2269:
2265:
2261:
2257:
2253:
2252:
2247:
2239:
2236:
2231:
2227:
2222:
2217:
2212:
2207:
2203:
2199:
2195:
2191:
2187:
2179:
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3536:Tom McLeish
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3464:John Goodby
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3439:Alan Cowman
3434:Stan Cowley
2976:"Dennis Lo"
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1726:"Dennis Lo"
1224:"Dennis Lo"
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1174:8 September
1137:8 September
1111:8 September
1027:Mathematics
987:Royal Medal
770:specificity
766:sensitivity
505:and by the
440:Li Ka Shing
207:Royal Medal
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3697:Categories
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3565:Sean Munro
3474:Clare Grey
3454:Ian Frazer
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2127:10 October
2066:The Lancet
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1622:The Lancet
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736:SARS virus
693:Rh disease
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810:prognosis
806:diagnosis
799:epigenome
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568:(PCR), a
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