235:. Fillers are not approved for certain parts of the body where they can be unsafe, including the penis. In Europe and the UK, fillers are non-prescription medical devices that can be injected by anyone licensed to do so by the respective medical authorities. They require a CE mark, which regulates adherence to production standards, but does not require any demonstration of medical efficacy. As a result, there are over 140 injectable fillers in the UK/European market and only six approved for use in the US. In China, the market of cosmetic surgery increase in recent 10 years, NMPA (formerly CFDA) also has issued several guidance to regulate injectable filler.
111:. In 2012, "Artiste Assisted Injection System" was launched in the US market to assist in the delivery of dermal fillers. A study in 2013 concluded that the injecting device can achieve reductions in patient discomfort and adverse events by controlling the rate of flow of injection of the filler the practitioner is using to fill in the lips and frown lines.
118:(HA) based dermal fillers. These non-permanent injectables can restore lost volume, smooth fine lines and wrinkles, and enhance facial contours. Despite their widespread use since the late 1990s, there is limited comparative data and literature on the diverse range of HA fillers and their tissue performance.
174:
Most wrinkle fillers are temporary because they are eventually metabolized by the body. Some people may need more than one injection to achieve the wrinkle-smoothing effect. The effect lasts for about six months. Results depend on health of the skin, skill of the health care provider, and the type of
133:
The scientific community emphasizes the importance of understanding the physico-chemical properties of fillers, such as their behavior under stress and deformation, and their performance over time. These properties are influenced by different crosslinking technologies used in manufacturing.
137:
A literature search identified key studies on the rheological properties of HA fillers, focusing on FDA-approved products and others like
Revolax. The review analyzes methodologies and critiques the existing literature to provide a comprehensive understanding of HA fillers' properties.
175:
filler used. Regardless of material (whether synthetic or organic) filler duration is highly dependent on amount of activity in the body area where it is injected. Exercise and high intensity activities such as manual labor can stimulate blood flow and shorten the lifespan of fillers.
183:
Risks of an improperly performed dermal filler procedure commonly include bruising, redness, pain, or itching. Less commonly, there may be infections or allergic reactions, which may cause scarring and lumps that may require surgical correction. In 2024, a cluster of
121:
The studies explore various methods and parameters for characterizing dermal fillers, providing key insights for clinicians to select the most suitable products for their patients. The aging face undergoes complex changes due to
130:, fat redistribution, and skin damage, which dermal fillers aim to counteract. HA fillers are considered medical devices rather than medicines, thus lacking stringent regulatory requirements for safety and efficacy data.
743:
Sturm, Lana P.; Cooter, Rodney D.; Mutimer, Keith L.; Graham, John C.; Maddern, Guy J. (September 2009). "A Systematic Review of
Permanent and Semipermanent Dermal Fillers for HIV-Associated Facial Lipoatrophy".
699:
Sturm, Lana P.; Cooter, Rodney D.; Mutimer, Keith L.; Graham, John C.; Maddern, Guy J. (September 2009). "A systematic review of permanent and semipermanent dermal fillers for HIV-associated facial lipoatrophy".
927:
Souza Felix Bravo, B; Klotz De
Almeida Balassiano, L; Roos Mariano Da Rocha, C; Barbosa De Sousa Padilha, C; Martinezt Torrado, C; Teixeira Da Silva, R; Carlos Regazzi Avelleira, J (December 2015).
75:. The variety of available dermal fillers increases annually, requiring dermatologists and cosmetic surgeons to stay informed about the latest options to ensure safe and effective treatments.
188:
was described amongst clients receiving microneedling facials at a Spa. More rarely, serious adverse effects such as blindness due to retrograde (opposite the direction of normal blood flow)
1011:
95:
which may come from pigs, cows, cadavers, or may be generated in a laboratory, the person's own transplanted fat tissue, and/or biosynthetic polymers. Examples of the latter include
839:"Investigation of Presumptive HIV Transmission Associated with Receipt of Platelet-Rich Plasma Microneedling Facials at a Spa Among Former Spa Clients — New Mexico, 2018–2023"
220:(FDA) and the injection is prescribed and performed by a provider. What defines a qualified dermal injection provider varies by country and is a point of debate between
892:
Ferneini, EM; Ferneini, AM (August 2016). "An
Overview of Vascular Adverse Events Associated With Facial Soft Tissue Fillers: Recognition, Prevention, and Treatment".
611:"A randomized open-label study of immediate versus delayed polylactic acid injections for the cosmetic management of facial lipoatrophy in persons with HIV infection"
146:
Dermal fillers, also known as "injectables" or "soft-tissue fillers," fill in the area under the skin, and have some non-cosmetic uses, such as non-surgical
166:
therapy. A 2009 review concluded that injectable fillers resulted in high satisfaction, but further research was needed to determine safety of its use.
968:
Beleznay, K; Carruthers, JD; Humphrey, S; Jones, D (October 2015). "Avoiding and
Treating Blindness From Fillers: A Review of the World Literature".
808:
44:, provide facial volume, and augment facial features. Side effects include bruising or infections from improper sterilisation. This may include
558:
Gooderham, Melinda; Solish, Nowell (2006-03-21). "Use of
Hyaluronic Acid for Soft Tissue Augmentation of HIV-Associated Facial Lipodystrophy".
1019:
48:, also allergic reactions, which may cause scarring and lumps. Blindness due to retrograde (opposite the direction of normal blood flow)
63:
Injection of dermal fillers is the second most common nonsurgical cosmetic procedure in the USA, used for addressing volume deficiency,
200:
can occur. Delayed skin necrosis can also occur as a complication of embolization. Embolic complications are more frequently seen when
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1125:
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816:
792:
217:
159:
354:
Bray, Dominic; Hopkins, Claire; Roberts, David N. (2010). "A review of dermal fillers in facial plastic surgery".
1120:
96:
163:
104:
609:
Moyle, GJ; Lysakova, L.; Brown, S.; Sibtain, N.; Healy, J.; Priest, C.; Mandalia, S.; Barton, SE (2004).
462:"Safety and efficacy of a continuous-flow, injection-assisted device in delivery of dermal fillers"
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652:"A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA)"
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Soft-tissue augmentation has grown in popularity recently, particularly with the use of
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33:(injectable cosmetic filler, injectable facial filler) is a soft tissue filler made of
838:
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627:
610:
446:
391:
185:
45:
1044:; Roberts, David N. (2010). "A review of dermal fillers in facial plastic surgery".
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1096:"The Overview of Requirement for High Risk Cosmetic Devices in Different Countries"
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929:"Delayed-type Necrosis after Soft-tissue Augmentation with Hyaluronic Acid"
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154:: Fillers were found to give a temporary acceptable therapeutic effect in
155:
92:
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Lorenc, Z. Paul; Bruce, Suzanne; Werschler, William Philip (July 2013).
650:
Jagdeo, Jared; Ho, Derek; Lo, Alex; Carruthers, Alastair (2015-12-01).
127:
71:, and enhancing facial features and specific anatomical sites like the
68:
41:
526:
321:
208:. Though rare, when vision loss does occur, it is usually permanent.
305:"Use of hyaluronic acid fillers for the treatment of the aging face"
224:
and injectors who operate under cosmetic or aesthetician licenses.
405:
Liu, Michael H.; Beynet, David P.; Gharavi, Nima M. (June 2019).
64:
151:
72:
1046:
Current
Opinion in Otolaryngology & Head and Neck Surgery
356:
Current
Opinion in Otolaryngology & Head and Neck Surgery
150:
repair or cleft modification, treating fat loss secondary to
1018:. Center for Devices and Radiological Health. Archived from
216:
In the US, fillers are approved as medical devices by the
515:
Indian
Journal of Dermatology, Venereology and Leprology
511:"Standard guidelines for the use of dermal fillers"
933:The Journal of Clinical and Aesthetic Dermatology
788:"Consumer Updates - Filling in Wrinkles Safely"
91:, a naturally occurring in skin and cartilage,
656:Journal of the American Academy of Dermatology
807:Health, Center for Devices and Radiological.
8:
37:injected into the skin at different depths.
843:MMWR. Morbidity and Mortality Weekly Report
266:"The rheology of hyaluronan dermal fillers"
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894:Journal of Oral and Maxillofacial Surgery
862:
667:
626:
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477:
330:
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1012:"Dermal Fillers (Soft Tissue Fillers)"
158:‐infected patients with severe facial
204:fat is used as a filler, followed by
7:
227:Fillers are not to be confused with
27:Fillers for cosmetic skin smoothing
25:
837:Stadelman-Behar, Anna M. (2024).
407:"Overview of Deep Dermal Fillers"
628:10.1111/j.1468-1293.2004.00190.x
270:Journal of Drugs in Dermatology
572:10.1111/j.1524-4725.2005.31020
1:
1058:10.1097/MOO.0b013e32833b5162
982:10.1097/dss.0000000000000486
817:Food and Drug Administration
793:Food and Drug Administration
368:10.1097/MOO.0b013e32833b5162
218:Food and Drug Administration
1147:
906:10.1016/j.joms.2016.03.009
746:AIDS Patient Care and STDs
702:AIDS Patient Care and STDs
669:10.1016/j.jaad.2015.08.040
1131:Drugs developed by AbbVie
509:Vedamurthy, Maya (2008).
466:Aesthetic Surgery Journal
282:10.1007/s40257-015-0135-7
40:They help fill in facial
479:10.1177/1090820X13487372
162:caused by highly active
222:board-certified doctors
97:calcium hydroxylapatite
1126:Plastic surgery filler
855:10.15585/mmwr.mm7316a3
423:10.1055/s-0039-1688843
411:Facial Plastic Surgery
264:Goldie, Karyl (2015).
179:Side effects and risks
105:polymethylmethacrylate
758:10.1089/apc.2008.0230
714:10.1089/apc.2008.0230
970:Dermatologic Surgery
662:(6): 1040–1054.e14.
560:Dermatologic Surgery
83:Fillers are made of
1116:Implants (medicine)
212:Society and culture
527:10.1111/dth.15453
322:10.2147/cia.s1244
309:Clin Interv Aging
31:Injectable filler
16:(Redirected from
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245:Cosmetic surgery
198:retinal arteries
170:Pharmacokinetics
101:polycaprolactone
89:hyaluronic acids
58:retinal arteries
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116:hyaluronic acid
109:polylactic acid
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35:polysaccharides
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79:Materials used
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46:HIV infection
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18:Dermal filler
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1024:. Retrieved
1020:the original
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876:. Retrieved
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615:HIV Medicine
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190:embolization
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148:facial cleft
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142:Medical uses
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50:embolization
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30:
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1016:www.fda.gov
229:neurotoxins
60:can occur.
1110:Categories
1026:2018-03-14
878:2024-04-25
823:2015-03-07
251:References
202:autologous
194:ophthalmic
54:ophthalmic
1082:205831647
1066:1531-6998
998:205583192
766:1087-2914
722:1557-7449
678:0190-9622
580:1076-0512
488:1527-330X
447:189816072
431:0736-6825
392:205831647
376:1531-6998
192:into the
93:collagens
52:into the
1074:20543696
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955:26705447
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596:22820504
588:15720106
545:35293660
496:23671210
439:31189194
384:20543696
341:18044187
290:26081021
239:See also
231:such as
87:such as
69:wrinkles
42:wrinkles
1098:. 2019.
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332:2685277
128:gravity
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1078:S2CID
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443:S2CID
388:S2CID
233:Botox
65:scars
1070:PMID
1062:ISSN
986:PMID
951:PMID
910:PMID
869:PMID
770:PMID
762:ISSN
726:PMID
718:ISSN
682:PMID
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576:ISSN
541:PMID
492:PMID
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435:PMID
427:ISSN
380:PMID
372:ISSN
337:PMID
286:PMID
196:and
73:lips
56:and
1054:doi
978:doi
941:PMC
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664:doi
623:doi
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317:doi
278:doi
156:HIV
152:HIV
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