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DSS is thought to induce colitis by causing injury to the colonic epithelium. The sulphate groups make the dextran molecules highly negatively charged and induce erosions in the epithelium, eventually compromising its integrity and increasing its permeability, while DSS's anticoagulant action
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DSS-induced colitis is the most widely used mouse model of colitis, such as is seen in inflammatory bowel disease (IBD). Acute colitis can be achieved within 7-10 days, while chronic colitis can be induced by 3-5 cycles of the former with 1-2 weeks in between each cycle.
221:"Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis"
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Except where otherwise noted, data are given for materials in their
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Jamwal, Sumit; Kumar, Puneet (2017-01-01), Conn, P. Michael (ed.),
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Animal Models for the Study of Human
Disease (Second Edition)
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Eichele, Derrick D; Kharbanda, Kusum K (2017-09-07).
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238:10.3748/wjg.v23.i33.6016
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206:References
165:to induce
143:(DSS), or
29:CAS Number
333:chemistry
247:1007-9327
197:Mechanism
180:of 36–50
152:sulphated
149:synthetic
78:618-471-1
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256:5597494
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171:Dextran
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