87:. One of these features is that activity propagated through a network needs to have a 'causal' character. For example, chain of reciprocally connected neurons with this ‘causal activity’ characteristic would be capable of propagating a wave of spikes along its length, rather than the wave disintegrating into a cascade of spikes ‘bouncing’ back and forth between neurons in the chain.
108:, for example), thus providing a means by which a network can actively control when and to what extent didactic organisation can occur. For this reason, and the very specific connectivity patterns that can be achieved via didactic organisation, it has been speculated that didactic organisation may play an important role in brain development.
193:
187:
95:
A third important feature for didactic organisation in vivo concerns the spatial scale of spike propagation within a network. While it is expected that didactic organisation will always be present among neurons that exhibit spike timing-dependent plasticity and causal activity (see above), the
31:
to other neurons. The term didactic is used because this kind of influence is unidirectional; each individual instance of didactic organisation between two connected neurons does not involve a bidirectional transfer of connectivity or response property information between them.
96:
spatial scale over which didactic organisation can occur between neurons within a network should be limited by the spatial scale of spike propagation. Evidence suggests that the scale of spike propagation can be actively controlled by adjusting the balance of
175:
Young, J. M.; Waleszczyk, W.J.; Wang, C.; Calford, M. B.; Dreher, B.; Obermayer, K., Cortical reorganization consistent with spike timing- but not correlation-dependent plasticity Nature
Neuroscience, 2007. 10(7): p. 887-895.
206:
46:
was first discovered through research into synaptic reorganisation in primary visual cortex that compared the results of neuronal recording experiments and computational models. However, the tendency of
83:
While spike-timing-dependent plasticity is an essential ingredient for didactic organisation, other features of neuronal activity appear to be required for didactic organisation to occur
59:
Didactic organisation is primarily a consequence of spike-timing-dependent plasticity, because when the neurons within an interconnected network undergo
186:
Song, S. and L.F. Abbott, Cortical development and remapping through spike timing-dependent plasticity Neuron, 2001. 32(2): p. 339-50.
51:
to separate neurons into ‘teachers’ and ‘students’ had previously been predicted in theory based on computational modelling results alone.
192:
Goodhill, G.J., Contributions of theoretical modeling to the understanding of neural map development Neuron, 2007. 56(2): p. 301-11.
122:
101:
97:
48:
220:
177:
71:), while neurons that spike late will have the efficacy of their efferent synaptic connections decreased (
68:
28:
72:
117:
105:
60:
63:(or ‘spikes’) at approximately the same time (within the order of tens of milliseconds) the
64:
214:
181:
42:
24:
20:
67:
of neurons that spike early will have their efficacy increased (
205:
Non-specialist description of didactic organisation research
104:
within a network (a balance that can be modulated by
8:
23:within a network to impart their pattern of
143:
141:
139:
137:
133:
159:
157:
36:Experimental and theoretical evidence
7:
40:Evidence for didactic organisation
14:
123:Spike-timing-dependent plasticity
55:Spike-timing-dependent plasticity
49:spike-timing-dependent plasticity
1:
65:efferent synaptic connections
237:
182:Supplementary information
69:long-term potentiation
163:Song and Abbott, 2001
25:synaptic connectivity
17:Didactic organisation
91:Activity propagation
73:long-term depression
178:Link to paper (PDF)
118:Synaptic plasticity
29:response properties
19:is the ability of
61:action potentials
228:
164:
161:
152:
145:
106:synaptic scaling
236:
235:
231:
230:
229:
227:
226:
225:
211:
210:
202:
172:
167:
162:
155:
146:
135:
131:
114:
93:
81:
79:Causal activity
57:
38:
12:
11:
5:
234:
232:
224:
223:
213:
212:
209:
208:
201:
200:External links
198:
197:
196:
190:
184:
171:
168:
166:
165:
153:
132:
130:
127:
126:
125:
120:
113:
110:
92:
89:
80:
77:
56:
53:
37:
34:
13:
10:
9:
6:
4:
3:
2:
233:
222:
221:Neural coding
219:
218:
216:
207:
204:
203:
199:
195:
194:Link to paper
191:
189:
188:Link to paper
185:
183:
179:
174:
173:
169:
160:
158:
154:
150:
144:
142:
140:
138:
134:
128:
124:
121:
119:
116:
115:
111:
109:
107:
103:
99:
90:
88:
86:
78:
76:
74:
70:
66:
62:
54:
52:
50:
45:
44:
35:
33:
30:
26:
22:
18:
148:
94:
84:
82:
58:
41:
39:
16:
15:
170:References
102:inhibition
98:excitation
215:Category
112:See also
85:in vivo
43:in vivo
27:and/or
21:neurons
151:, 2007
149:et al.
147:Young
129:Notes
180:and
100:and
75:).
217::
156:^
136:^
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.