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intestinal malabsorption and chronic oral antibiotic administration. These are objectives of these poisons, as the sick animal normally stays in its nest, removing the need to clean up/dispose of dead animals. Often the target animals will remain healthy enough to feed several times and possibly bring poisoned foods back to feed their young. The poison is effectively transferred through milk of mothers to nursing mammalian infants.
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Because other species of mammals and birds may prey upon affected rodents, or directly ingest rodenticide bait, there is a risk of primary, secondary or tertiary exposure; examples are described in a 2012 publication on veterinary toxicology. Using radiolabeled isotopes, difenacoum (and/or its
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Vitamin K deficiency in animals is deliberately brought about by anticoagulant rodenticide toxicities. Vitamin K deficiency causes internal bleeding and hemorrhaging, resulting in a slow, painful death. Other vitamin K deficient states include: biliary obstruction, intrahepatic cholestasis,
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Vitamin K reverses the anticoagulant effect of rodenticides over a period of 24 to 48 hours from initiation of therapy. Caught early enough, Vitamin K can be rapidly administered by subcutaneous injection and followed up with by food-based supplements.
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Difenacoum has been shown to be highly toxic to some species of freshwater fish and green algae despite the fact that difenacoum is weakly soluble in aqueous solutions.
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metabolites) has been shown to be distributed across many organ tissues upon oral ingestion, with the highest concentrations occurring in the liver and pancreas.
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InChI=1S/C31H24O3/c32-30-26-12-6-7-13-28(26)34-31(33)29(30)27-19-24(18-23-10-4-5-11-25(23)27)22-16-14-21(15-17-22)20-8-2-1-3-9-20/h1-17,24,27,32H,18-19H2
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Difenacoum was first introduced in 1976 as a rodenticide effective against rats and mice which were resistant to other anticoagulants.
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211.0 to 215.0 °C (411.8 to 419.0 °F; 484.1 to 488.1 K) (98.7% wlw)
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531:. It was first introduced in 1976 and first registered in the USA in 2007.
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Except where otherwise noted, data are given for materials in their
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O=c1c(C2CC(c3ccc(-c4ccccc4)cc3)Cc3ccccc32)c(O)oc2ccccc12
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3--4-yl)-1,2,3,4-tetrahydronapthalen-1-yl]-4-hydroxy-2
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Veterinary
Toxicology: Basic and clinical principles
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46:. Unsourced material may be challenged and removed.
539:Difenacoum is sold as blue-green and red pellets.
614:"University of Hertfordshire: IUPAC: difenacoum"
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502:Professional bitebox containing difenacoum
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106:Learn how and when to remove this message
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527:effects and is used commercially as a
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366:Key: FVQITOLOYMWVFU-UHFFFAOYSA-N
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640:. Academic Press. pp. 673–697.
44:adding citations to reliable sources
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1090:1,3-Difluoro-2-propanol (Gliftor)
563:Diagnosis Symptoms and Treatment
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460:(at 25 °C , 100 kPa).
31:needs additional citations for
909:Tetramethylenedisulfotetramine
634:Gupta, Ramesh C. (ed) (2012).
1:
551:Safety treatment and toxicity
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1146:Anticoagulant rodenticides
430:444.52 g/mol
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914:Chlorophenylsilatrane
761:Vitamin K antagonists
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1110:Sodium fluoroacetate
521:vitamin K antagonist
139:Preferred IUPAC name
40:improve this article
960:Aluminium phosphide
952:Inorganic compounds
703:"Vitamin K Therapy"
689:"Vitamin K Therapy"
147:-1-benzopyran-2-one
120:
1151:4-Hydroxycoumarins
1070:α-Naphthylthiourea
775:4-Hydroxycoumarins
705:. 8 February 2019.
691:. 8 February 2019.
673:has generic name (
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487:Infobox references
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975:Calcium phosphide
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593:"EPA: Difenacoum"
518:4-hydroxycoumarin
495:Chemical compound
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440:1.27 (98.7% w/w)
319:CompTox Dashboard
203:Interactive image
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1023:Organophosphorus
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970:Barium carbonate
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403:Chemical formula
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942:Ergocalciferol
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795:Coumatetralyl
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525:anticoagulant
523:type. It has
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57: –
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51:Find sources:
45:
41:
35:
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29:This article
27:
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18:
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1105:Scilliroside
1085:Flupropadine
835:Difethialone
829:
825:Bromadiolone
748:Rodenticides
744:Pest control
697:
683:
651:. Retrieved
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617:. Retrieved
608:
596:. Retrieved
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162:Identifiers
154:Other names
144:
102:
93:
83:
76:
69:
62:
55:"Difenacoum"
50:
38:Please help
33:verification
30:
1075:Bromethalin
929:Calciferols
886:Convulsants
872:Diphacinone
840:Flocoumafen
820:Brodifacoum
535:Formulation
529:rodenticide
504:and others.
396:Properties
241:100.054.508
156:Diphenacoum
119:Difenacoum
1125:Categories
1095:Norbormide
1041:Carbamates
1031:Phosacetim
1008:Chloralose
904:Strychnine
830:Difenacoum
579:References
572:Treatment:
510:Difenacoum
426:Molar mass
307:SBA3K9U26B
214:ChemSpider
190:3D model (
179:56073-07-5
169:CAS Number
96:April 2015
66:newspapers
1141:Biphenyls
1136:Tetralins
1100:Pyrinuron
894:Crimidine
770:Coumarins
663:cite book
1049:Aldicarb
790:Warfarin
287:54676884
223:10469075
980:Cyanide
965:Arsenic
867:Pindone
800:Fumarin
653:3 April
619:3 April
598:3 April
516:of the
480:what is
478: (
436:Density
420:
274:PubChem
80:scholar
1063:Others
1054:T-1152
1013:Endrin
644:
512:is an
475:verify
472:
380:SMILES
262:C16807
133:Names
82:
75:
68:
61:
53:
355:InChI
192:JSmol
87:JSTOR
73:books
675:help
655:2015
642:ISBN
621:2015
600:2015
543:Uses
298:UNII
253:KEGG
59:news
919:RDX
324:EPA
277:CID
42:by
1127::
746::
667::
665:}}
661:{{
414:24
410:31
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772:/
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736:e
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623:.
602:.
470:N
418:3
416:O
412:H
408:C
326:)
322:(
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145:H
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103:(
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94:(
84:·
77:·
70:·
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36:.
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