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The type and distribution of lesions varies among the two different types of VIN. In the Usual type VIN, seen more frequently in young patients, lesions tend to be multifocal over an otherwise normal vulvar skin. In the differentiated type VIN, usually seen in postmenopausal women, lesions tend to be
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269:: associated with developing into the warty and basaloid type carcinoma. This is associated with carcinogenic genotypes of HPV and/or HPV persistence factors such as cigarette smoking or immunocompromised states.
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Sideri M, Jones RW, Wilkinson EJ, Preti M, Heller D,. Scurry J, Haefner H, Neill S. 2004 Modified
Terminology, ISSVD Vulvar Oncology Subcommittee. Journal of Reproductive Medicine. 2005;50:807-10.
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The ISSVD further revised this classification in 2004, replacing the three-grade system with a single-grade system in which only the high-grade disease is classified as VIN.
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The person may have no symptoms, or local symptomatology including itching, burning, and pain. The diagnosis is always based on a careful inspection and a targeted
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455:"Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015"
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415:
Ridley CM, Frankman O, Jones IS, et al. (May 1989). "New nomenclature for vulvar disease: International
Society for the Study of Vulvar Disease".
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also known as VIN Simplex: is associated with vulvar dermatoses such as lichen sclerosus. It is associated with atypia of the squamous epithelium.
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The exact cause of VIN is unknown. Studies are being done to determine the cause of VIN. The following factors have been associated with VIN:
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536:"FDA Approves Expanded Uses for Gardasil to Include Preventing Certain Vulvar and Vaginal Cancers"
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Schnürch, H.; Ackermann, S.; Alt, C.; Barinoff, J.; Böing, C.; Dannecker, C.; et al. (2016).
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The terminology of VIN evolved over several decades. In 1989 the
Committee on Terminology,
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isolated and are located over a skin with a vulvar dermatosis such as Lichen slerosus.
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Squamous vulvar intraepithelial neoplasia (VIN), previously classified as VIN 1-3:
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before their initial sexual contact has been claimed to reduce incidence of VIN.
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is intact and the lesion is thus not invasive but has invasive potential.
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VIN is subdivided into: (Robbins
Pathological Basis of Disease, 9th Ed)
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HPV-negative lesion with atypical keratinocytes in the basal cell layer
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Medically speaking, the term denotes a squamous intraepithelial
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but if the changes become more severe, there is a chance of
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developing after many years, and so it is referred to as a
142:, and Kraurosis vulvae by a new classification system for
150:
Nonneoplastic epithelial disorders of vulva and mucosa:
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International
Society for the Study of Vulvar Disease
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of differentiated vulvar intraepithelial neoplasia.
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50:of (classic) vulvar intraepithelial neoplasia III.
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134:(ISSVD) replaced older terminology such as vulvar
221:High-grade squamous intraepithelial lesion (HSIL)
218:Low-grade squamous intraepithelial lesion (LSIL)
87:, and can disappear without treatment. VINs are
273:Differentiated vulvar intraepithelial neoplasia
224:Intraepithelial neoplasia, differentiated type
18:Differentiated vulvar intraepithelial neoplasia
506:"Vulvar Disease | Research and Education"
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166:Mixed neoplastic and nonneoplastic disorders
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393:. Macmillan Cancer Support. Archived from
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1469:Loop electrical excision procedure (LEEP)
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391:"Vulval intra-epithelial neoplasia (VIN)"
336:of vulvar intraepithelial neoplasia III.
1443:Vaginal intraepithelial neoplasia (VAIN)
1433:Cervical intraepithelial neoplasia (CIN)
267:Classic vulvar intraepithelial neoplasia
201:Vulvar intraepithelial neoplasia (VIN) 1
177:
1092:Clear-cell adenocarcinoma of the vagina
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498:
382:
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233:Non-squamous intraepithelial neoplasia
1448:Vulvar intraepithelial neoplasia (VIN)
1082:Squamous-cell carcinoma of the vagina
973:Endometrial intraepithelial neoplasia
292:HSV-2 (Herpes simplex Virus - Type 2)
7:
810:Sex cord tumour with annular tubules
190:Severe dysplasia / carcinoma in situ
728:Papillary serous cystadenocarcinoma
304:Conditions such as Lichen Sclerosus
996:Cervical intraepithelial neoplasia
968:Uterine papillary serous carcinoma
25:
1244:HPV-positive oropharyngeal cancer
1097:Vaginal intraepithelial neoplasia
1039:Gestational trophoblastic disease
1140:Vulvar intraepithelial neoplasia
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326:
73:Vulvar intraepithelial neoplasia
33:Vulvar intraepithelial neoplasia
1287:Epidermodysplasia verruciformis
1:
1016:Villoglandular adenocarcinoma
1292:Focal epithelial hyperplasia
1135:Extramammary Paget's disease
978:Uterine clear-cell carcinoma
753:Ovarian clear-cell carcinoma
541:Food and Drug Administration
429:10.1016/0046-8177(89)90019-1
317:of a visible vulvar lesion.
237:Extramammary Paget's disease
289:HPV (Human Papilloma Virus)
1536:
935:Uterine fibroids/leiomyoma
790:Sertoli–Leydig cell tumour
713:Ovarian serous cystadenoma
169:Intraepithelial neoplasia
1394:Experimental techniques:
1145:Bartholin gland carcinoma
1087:Botryoid rhabdomyosarcoma
743:
459:Geburtshilfe Frauenheilkd
301:Chronic vulvar irritation
217:
144:Epithelial Vulvar Disease
85:intraepithelial neoplasia
46:
37:
1515:Gynaecological neoplasia
1282:Laryngeal papillomatosis
772:Sex cord–gonadal stromal
691:Glandular and epithelial
119:with varying degrees of
369:Vaccinating girls with
215:WHO 2014 and ISSVD 2015
843:Endodermal sinus tumor
97:precancerous condition
1489:Georgios Papanikolaou
1130:Papillary hidradenoma
1060:Mixed MĂĽllerian tumor
1011:Glassy-cell carcinoma
800:Granulosa cell tumour
471:10.1055/s-0042-103728
1240:Head and neck cancer
1186:Human papillomavirus
1001:Clear-cell carcinoma
718:Mucinous cystadenoma
158:Squamous hyperplasia
1464:Cervical conization
838:Embryonal carcinoma
785:Sertoli cell tumour
696:surface epithelial-
963:Endometrioid tumor
780:Leydig cell tumour
748:Endometrioid tumor
723:Cystadenocarcinoma
252:Invasive disease (
187:Moderate dysplasia
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1494:Harald zur Hausen
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904:Adenomatoid tumor
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665:urogenital system
625:VIN at DermNet.NZ
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465:(10): 1035–1049.
298:Immunosuppression
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125:basement membrane
123:. The epithelial
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27:Medical condition
16:(Redirected from
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735:Krukenberg tumor
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154:Lichen sclerosus
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397:on 2010-06-26
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1398:Speculoscopy
1335:HPV vaccines
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828:Dysgerminoma
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546:. Retrieved
544:. 2008-09-12
539:
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510:. Retrieved
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423:(5): 495–6.
420:
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399:. Retrieved
395:the original
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281:Risk factors
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83:. VIN is an
76:
72:
71:
955:Endometrium
417:Hum. Pathol
371:HPV vaccine
243:melanocytes
115:that shows
1509:Categories
1415:Colposcopy
945:Adenomyoma
927:Myometrium
548:2010-02-13
512:2022-04-20
401:2010-06-09
377:References
365:Prevention
353:Micrograph
334:Micrograph
241:Tumors of
65:Gynecology
48:Micrograph
1457:Treatment
1438:Koilocyte
1425:histology
1357:Screening
1314:skin tags
1297:Papilloma
820:Germ cell
309:Diagnosis
136:dystrophy
117:dysplasia
60:Specialty
1365:Pap test
1345:Gardasil
1340:Cervarix
1195:diseases
1125:Melanoma
1026:Placenta
853:Teratoma
597:D07.120)
489:27765958
198:WHO 2003
1482:History
1423:Biopsy
1327:Vaccine
1272:plantar
1267:genital
1225:Vaginal
1215:cancers
1203:Cancers
1193:Related
1048:General
874:Fibroma
805:Luteoma
795:Thecoma
682:Ovaries
508:. ISSVD
480:5066425
437:2707802
295:Smoking
111:of the
1308:Others
1235:Penile
1230:Vulvar
1074:Vagina
988:Cervix
918:Uterus
673:Adnexa
661:Tumors
611:233.32
487:
477:
435:
315:biopsy
210:VIN 3
181:Source
121:atypia
109:lesion
93:cancer
89:benign
1371:stain
1257:Warts
1112:Vulva
591:D07.1
207:VIN 3
204:VIN 2
113:vulva
81:vulva
1277:flat
1220:Anal
706:CMS:
606:9-CM
595:ILDS
485:PMID
433:PMID
1120:SCC
1006:SCC
602:ICD
582:ICD
475:PMC
467:doi
425:doi
77:VIN
1511::
1367::
609::
589::
586:10
538:.
497:^
483:.
473:.
463:76
461:.
457:.
445:^
431:.
421:20
419:.
146::
138:,
99:.
1316:)
1246:)
1242:(
1179:e
1172:t
1165:v
855:/
693:/
653:e
646:t
639:v
604:-
593:(
584:-
574:D
551:.
515:.
491:.
469::
439:.
427::
404:.
359:.
340:.
256:)
75:(
54:.
20:)
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