Knowledge (XXG)

Dioxolane

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that may be present. A variety of approaches to protection and deprotection of carbonyls including as dioxolanes are known. For example, consider the compound methyl cyclohexanone-4-carboxylate, where
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Chang, Chih-Ching; Liao, Bei-Sih; Liu, Shiuh-Tzung (2007). "Deprotection of Acetals and Ketals in a Colloidal Suspension Generated by Sodium Tetrakis(3,5-trifluoromethylphenyl)borate in Water".
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Ziegler, Fredrick E.; Metcalf, Chester A.; Nangia, Ashwini; Schulte, Gayle (1993). "Structure and total synthesis of sporol and neosporol".
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can also be used for deprotection of acetal or ketal-protected carbonyl compounds. For example, deprotection of 2-phenyl-1,3-dioxolane to
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Caster, Kenneth C.; Rao, A. Somasekar; Mohan, H. Rama; McGrath, Nicholas A.; Brichacek, Matthew (2012). "Trifluoroperacetic Acid".
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A similar approach is used in the total synthesis of sporol, with the dioxolane ring later expanded to a dioxane system.
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reduction will produce 4-hydroxymethylcyclohexanol. The ester functional group can be reduced without affecting the
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of both compounds has been reported, and each includes a step in which a dioxolane system is formed using
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Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book)
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peracid, necessary in this case as the presence of water would lead to unwanted
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Greene, Theodora W.; Wuts, Peter G. M. (1999). "1,3-Dioxanes, 1,3-Dioxolanes".
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This article is about 1,3-dioxolane. For the other dioxolane isomer, see
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Pirrung, Michael C.; Morehead, Andrew T.; Young, Bruce G., eds. (2000).
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so that they do not undergo reactions during transformations of other
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Except where otherwise noted, data are given for materials in their
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Greene, Theodora W.; Wuts, Peter G. M. (1999). "Dimethyl acetals".
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1,2-dioxolane (wherein the two oxygen centers are adjacent) is a
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method. This method involves no water, so it gives a completely
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containing the dioxolane ring. Dioxolanes can be prepared by
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with trifluoroperacetic acid is used to convert a suitable
1581: 1364:. The Total Synthesis of Natural Products. Vol. 11. 870: 792:. The ketal is produced by acid catalysed reaction with 816:
can be achieved in water in five minutes at 30 °C.
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Octatropine methylbromide (anisotropine methylbromide)
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e-EROS Encyclopedia of Reagents for Organic Synthesis
844: 2948: 1881: 1593: 1579: 1503:Name Reactions of Functional Group Transformations 880: 2663:Scopolamine butylbromide (hyoscine butylbromide) 1138:formal glycol - PubChem Public Chemical Database 259: 2688:Tooltip Selective serotonin reuptake inhibitors 1284:Greene's Protective Groups in Organic Synthesis 1238:Greene's Protective Groups in Organic Synthesis 113: 3052:Acetylcholine metabolism/transport modulators 1554: 1362:Part B: Bicyclic and Tricyclic Sesquiterpenes 1084:functional group to form the dioxolane ring. 8: 1420: 1418: 3047:Nicotinic acetylcholine receptor modulators 2623:3-Quinuclidinyl thiochromane-4-carboxylate 1590: 1586:Tooltip Muscarinic acetylcholine receptors 1561: 1547: 1539: 322: 219: 197: 22: 1351: 1349: 1276: 1274: 869: 864: 859: 852: 846: 845: 843: 279: 1230: 1228: 1115: 444:−95 °C (−139 °F; 178 K) 378: 343: 318: 1389: 1387: 1385: 210: 1305:from the original on December 7, 2016 1259:from the original on December 3, 2016 1204:R. A. Daignault, E. L. Eliel (1973). 454:75 °C (167 °F; 348 K) 350:Key: SNQXJPARXFUULZ-UHFFFAOYSA-N 177: 157: 7: 1534:environmental and toxicological data 925:which has a 1,3-dioxane ring. The 360:Key: SNQXJPARXFUULZ-UHFFFAOYAS 347:InChI=1S/C3H6O2/c1-2-4-5-3-1/h1-3H2 250: 357:InChI=1/C3H6O2/c1-2-4-5-3-1/h1-3H2 14: 2285:Etybenzatropine (ethybenztropine) 1957:chlorphenamine (chlorpheniramine) 1941:Antihistamines (first-generation) 1718:Desmethylclozapine (norclozapine) 1570:Muscarinic acetylcholine receptor 754:muscarinic acetylcholine receptor 582: 482: 3006:Meclofenoxate (centrophenoxine) 2824:northiaden (desmethyldosulepin) 578:(at 25 °C , 100 kPa). 2463:N-Methyl-3-piperidyl benzilate 1155:The Royal Society of Chemistry 935:hydrogen peroxide – urea 917:that includes a 1,3-dioxolane 788:by protecting the ketone as a 1: 3042:Receptor/signaling modulators 2458:N-Ethyl-3-piperidyl benzilate 1437:10.1002/047084289X.rt254.pub2 1291:. pp. 308–322, 724–727. 1245:. pp. 297–304, 724–727. 881:{\displaystyle {\ce {->}}} 767:Organic compounds containing 678:. 1,3-dioxolane is used as a 2898:cyamemazine (cyamepromazine) 1068:In the case of neosporol, a 732:synthesis of dioxolane group 650:(THF) by replacement of the 2712:Tetracyclic antidepressants 2603:Profenamine (ethopropazine) 2225:Dicycloverine (dicyclomine) 1163:10.1039/9781849733069-FP001 29: 3109: 2861:Tripitamine (tripitramine) 2085:Benzatropine (benztropine) 1493:Hagen, Timothy J. (2007). 1220:, vol. 5, p. 303 15: 3034: 2764:Tricyclic antidepressants 2314:+beclometasone/formoterol 1891:3-Quinuclidinyl benzilate 933:(TFPAA), prepared by the 782:lithium aluminium hydride 572: 463: 458: 424:74.08 g/mol 389: 369: 334: 97: 85: 73: 61: 56: 28: 3016:Phosphatidylethanolamine 1191:pubchem.ncbi.nlm.nih.gov 888: PhCHO +  521:Precautionary statements 2240:Diphemanil metilsulfate 2095:Benzilylcholine mustard 2042:Atypical antipsychotics 1358:"10. Neosporol, Sporol" 931:trifluoroperacetic acid 694:As a class of compounds 2886:Typical antipsychotics 2658:Scopolamine (hyoscine) 2333:Hexahydrosiladifenidol 2310:Glycopyrronium bromide 1091: 921:, and is an isomer of 882: 875: 803: 733: 47: 38: 3001:Glycerophosphocholine 2804:dosulepin (dothiepin) 2608:Propantheline bromide 2483:Otenzepad (AF-DX 116) 2037:Atropine methonitrate 1507:John Wiley & Sons 1495:"Prilezhaev reaction" 1366:John Wiley & Sons 1340:10.1055/s-2007-968009 1157:. 2014. p. 145. 1090: 883: 847: 802: 731: 79:1,3-Dioxacyclopentane 75:Systematic IUPAC name 46: 37: 2996:Dimethylethanolamine 2916:Umeclidinium bromide 2796:desmethyldesipramine 2513:Oxyphenonium bromide 1723:Ethoxysebacylcholine 1509:. pp. 274–281. 1480:10.1055/s-1990-21156 1368:. pp. 222–224. 842: 63:Preferred IUPAC name 3078:Muscarinic agonists 3011:Phosphatidylcholine 2673:Sofpironium bromide 2558:Pipenzolate bromide 2368:Ipratropium bromide 2170:Cimetropium bromide 1497:. In Li, Jie Jack; 1409:10.1021/ja00060a006 1070:Prilezhaev reaction 874: 872: 857: 646:. It is related to 25: 2744:Tiotropium bromide 2739:Timepidium bromide 2498:Oxitropium bromide 2453:Muscarinic toxin 7 2328:Hexahydrodifenidol 2275:Emepronium bromide 1926:Ambutonium bromide 1901:Aclidinium bromide 1289:Wiley-Interscience 1243:Wiley-Interscience 1092: 878: 860: 854:30 °C / 5 min 804: 740:-Dioxolane is the 734: 605:Infobox references 48: 39: 23: 3088:Protecting groups 3060: 3059: 3021:Phosphorylcholine 2959: 2944: 2943: 2881:Trospium chloride 2776:amitriptylinoxide 2749:Tiquizium bromide 2593:Prifinium bromide 2488:Otilonium bromide 2443:Methylscopolamine 2438:Methylhomatropine 2295:Fentonium bromide 2175:Clidinium bromide 1460:Cooper, Mark S.; 1397:J. Am. Chem. Soc. 1218:Collected Volumes 1211:Organic Syntheses 1172:978-0-85404-182-4 863: 855: 777:functional groups 763:Protecting groups 747: 703:organic compounds 666:rings are called 613:Chemical compound 611: 610: 507:Hazard statements 303:CompTox Dashboard 139:Interactive image 52: 51: 3100: 2953: 2734:Tiemonium iodide 2689: 2685: 2553:Phenyltoloxamine 2508:Oxyphencyclimine 2009:phenyltoloxamine 1813:Suberyldicholine 1591: 1587: 1583: 1563: 1556: 1549: 1540: 1521: 1520: 1490: 1484: 1483: 1457: 1451: 1450: 1422: 1413: 1412: 1403:(7): 2581–2589. 1391: 1380: 1379: 1353: 1344: 1343: 1321: 1315: 1314: 1312: 1310: 1287:(3rd ed.). 1278: 1269: 1268: 1266: 1264: 1241:(3rd ed.). 1232: 1223: 1221: 1214: 1201: 1195: 1194: 1183: 1177: 1176: 1149:"Front Matter". 1146: 1140: 1135: 1129: 1120: 1076:precursor to an 1063: 1062: 1061: 1053: 1052: 1042:  +   1040: 1038: 1037: 1027:  +   1025: 1023: 1022: 1012:  →   1010: 1009: 1008: 1000: 999: 991: 990: 982: 981: 971:  +   969: 968: 967: 959: 958: 906:Natural products 887: 885: 884: 879: 877: 876: 873: 871: 868: 861: 856: 853: 830:  +   745: 628:chemical formula 595: 589: 586: 585: 568: 564: 560: 556: 552: 548: 544: 540: 536: 532: 528: 514: 486: 397:Chemical formula 327: 326: 311: 309: 283: 263: 252: 231: 223: 212: 201: 181: 161: 141: 117: 30: 26: 3108: 3107: 3103: 3102: 3101: 3099: 3098: 3097: 3063: 3062: 3061: 3056: 3030: 2952: 2940: 2894:chlorprothixene 2851:Trihexyphenidyl 2687: 2668:Silahexacyclium 2548:Phenglutarimide 2210:Desfesoterodine 2190:Cyclobenzaprine 1981:diphenhydramine 1945:brompheniramine 1877: 1828:Thiopilocarpine 1585: 1575: 1567: 1530: 1525: 1524: 1517: 1492: 1491: 1487: 1459: 1458: 1454: 1447: 1424: 1423: 1416: 1393: 1392: 1383: 1376: 1355: 1354: 1347: 1323: 1322: 1318: 1308: 1306: 1299: 1280: 1279: 1272: 1262: 1260: 1253: 1234: 1233: 1226: 1216: 1203: 1202: 1198: 1187:"1,3-Dioxolane" 1185: 1184: 1180: 1173: 1148: 1147: 1143: 1136: 1132: 1121: 1117: 1112: 1100: 1060: 1057: 1056: 1055: 1051: 1048: 1047: 1046: 1044: 1036: 1033: 1032: 1031: 1029: 1021: 1018: 1017: 1016: 1014: 1007: 1004: 1003: 1002: 998: 995: 994: 993: 989: 986: 985: 984: 980: 977: 976: 975: 973: 966: 963: 962: 961: 957: 954: 953: 952: 950: 927:total synthesis 915:natural product 908: 897: 893: 840: 839: 835: 829: 825: 810: 794:ethylene glycol 771:sometimes need 769:carbonyl groups 765: 723:ethylene glycol 701:are a group of 696: 665: 661: 657: 652:methylene group 648:tetrahydrofuran 645: 641: 637: 633: 614: 607: 602: 601: 600:  ?) 591: 587: 583: 579: 523: 509: 495: 479: 413: 409: 405: 399: 385: 382: 377: 376: 365: 362: 361: 358: 352: 351: 348: 342: 341: 330: 312: 305: 286: 266: 253: 241: 204: 184: 164: 144: 131: 120: 107: 93: 91: 89: 81: 80: 69: 68: 21: 12: 11: 5: 3106: 3104: 3096: 3095: 3090: 3085: 3080: 3075: 3065: 3064: 3058: 3057: 3055: 3054: 3049: 3044: 3039: 3035: 3032: 3031: 3029: 3028: 3023: 3018: 3013: 3008: 3003: 2998: 2993: 2988: 2983: 2973: 2968: 2962: 2960: 2946: 2945: 2942: 2941: 2939: 2938: 2933: 2928: 2923: 2913: 2890:chlorpromazine 2883: 2878: 2873: 2868: 2863: 2858: 2853: 2848: 2843: 2761: 2756: 2751: 2746: 2741: 2736: 2731: 2709: 2704: 2699: 2680: 2675: 2670: 2665: 2660: 2655: 2650: 2645: 2640: 2635: 2630: 2625: 2620: 2615: 2610: 2605: 2600: 2595: 2590: 2585: 2580: 2575: 2570: 2565: 2560: 2555: 2550: 2545: 2540: 2535: 2530: 2525: 2520: 2515: 2510: 2505: 2500: 2495: 2493:Oxapium iodide 2490: 2485: 2480: 2475: 2470: 2465: 2460: 2455: 2450: 2445: 2440: 2435: 2433:Methylatropine 2430: 2425: 2420: 2415: 2410: 2405: 2400: 2395: 2390: 2385: 2380: 2375: 2365: 2360: 2355: 2350: 2345: 2340: 2335: 2330: 2325: 2307: 2302: 2297: 2292: 2287: 2282: 2277: 2272: 2267: 2262: 2257: 2252: 2247: 2242: 2237: 2232: 2227: 2222: 2217: 2212: 2207: 2202: 2197: 2195:Cyclopentolate 2192: 2187: 2182: 2177: 2172: 2167: 2162: 2157: 2152: 2147: 2142: 2137: 2132: 2127: 2122: 2117: 2112: 2107: 2102: 2097: 2092: 2087: 2082: 2077: 2039: 2034: 2029: 2024: 1973:dimenhydrinate 1969:cyproheptadine 1938: 1933: 1928: 1923: 1918: 1913: 1908: 1898: 1893: 1887: 1885: 1879: 1878: 1876: 1875: 1870: 1865: 1860: 1855: 1850: 1845: 1840: 1835: 1830: 1825: 1820: 1815: 1810: 1808:Sebacylcholine 1805: 1800: 1795: 1790: 1785: 1780: 1775: 1770: 1765: 1760: 1755: 1750: 1745: 1740: 1735: 1730: 1725: 1720: 1715: 1710: 1705: 1700: 1695: 1690: 1685: 1680: 1675: 1670: 1665: 1663:Butyrylcholine 1660: 1655: 1650: 1645: 1640: 1635: 1630: 1625: 1620: 1615: 1610: 1605: 1599: 1597: 1588: 1577: 1576: 1568: 1566: 1565: 1558: 1551: 1543: 1537: 1536: 1529: 1528:External links 1526: 1523: 1522: 1515: 1485: 1474:(9): 533–535. 1452: 1446:978-0471936237 1445: 1414: 1381: 1374: 1345: 1334:(2): 283–287. 1316: 1297: 1270: 1251: 1224: 1196: 1178: 1171: 1141: 1130: 1114: 1113: 1111: 1108: 1107: 1106: 1099: 1096: 1066: 1065: 1058: 1049: 1034: 1019: 1005: 996: 987: 978: 964: 955: 943:side reactions 907: 904: 903: 902: 901: 900: 895: 891: 867: 850: 833: 827: 823: 808: 764: 761: 695: 692: 663: 659: 655: 643: 639: 635: 631: 612: 609: 608: 603: 581: 580: 576:standard state 573: 570: 569: 555:P303+P361+P353 524: 519: 516: 515: 510: 505: 502: 501: 496: 491: 488: 487: 480: 475: 472: 471: 461: 460: 456: 455: 452: 446: 445: 442: 436: 435: 432: 426: 425: 422: 416: 415: 411: 407: 403: 400: 395: 392: 391: 387: 386: 384: 383: 380: 372: 371: 370: 367: 366: 364: 363: 359: 356: 355: 353: 349: 346: 345: 337: 336: 335: 332: 331: 329: 328: 315: 313: 301: 298: 297: 294: 288: 287: 285: 284: 276: 274: 268: 267: 265: 264: 256: 254: 246: 243: 242: 240: 239: 235: 233: 225: 224: 214: 206: 205: 203: 202: 194: 192: 186: 185: 183: 182: 174: 172: 166: 165: 163: 162: 154: 152: 146: 145: 143: 142: 134: 132: 125: 122: 121: 119: 118: 110: 108: 103: 100: 99: 95: 94: 87: 83: 82: 78: 77: 71: 70: 66: 65: 59: 58: 54: 53: 50: 49: 40: 13: 10: 9: 6: 4: 3: 2: 3105: 3094: 3091: 3089: 3086: 3084: 3081: 3079: 3076: 3074: 3071: 3070: 3068: 3053: 3050: 3048: 3045: 3043: 3040: 3037: 3036: 3033: 3027: 3024: 3022: 3019: 3017: 3014: 3012: 3009: 3007: 3004: 3002: 2999: 2997: 2994: 2992: 2989: 2987: 2984: 2981: 2977: 2974: 2972: 2969: 2967: 2964: 2963: 2961: 2957: 2951: 2947: 2937: 2934: 2932: 2929: 2927: 2924: 2921: 2917: 2914: 2911: 2907: 2903: 2899: 2895: 2891: 2887: 2884: 2882: 2879: 2877: 2874: 2872: 2869: 2867: 2864: 2862: 2859: 2857: 2854: 2852: 2849: 2847: 2846:Tridihexethyl 2844: 2841: 2837: 2833: 2832:protriptyline 2829: 2828:nortriptyline 2825: 2821: 2820:nitroxazepine 2817: 2813: 2809: 2805: 2801: 2797: 2793: 2789: 2785: 2781: 2777: 2773: 2772:+perphenazine 2769: 2768:amitriptyline 2765: 2762: 2760: 2757: 2755: 2752: 2750: 2747: 2745: 2742: 2740: 2737: 2735: 2732: 2729: 2725: 2721: 2717: 2713: 2710: 2708: 2705: 2703: 2700: 2697: 2693: 2686: 2681: 2679: 2676: 2674: 2671: 2669: 2666: 2664: 2661: 2659: 2656: 2654: 2651: 2649: 2646: 2644: 2641: 2639: 2636: 2634: 2631: 2629: 2626: 2624: 2621: 2619: 2616: 2614: 2611: 2609: 2606: 2604: 2601: 2599: 2596: 2594: 2591: 2589: 2586: 2584: 2581: 2579: 2576: 2574: 2571: 2569: 2566: 2564: 2561: 2559: 2556: 2554: 2551: 2549: 2546: 2544: 2541: 2539: 2536: 2534: 2531: 2529: 2526: 2524: 2521: 2519: 2516: 2514: 2511: 2509: 2506: 2504: 2501: 2499: 2496: 2494: 2491: 2489: 2486: 2484: 2481: 2479: 2476: 2474: 2471: 2469: 2466: 2464: 2461: 2459: 2456: 2454: 2451: 2449: 2446: 2444: 2441: 2439: 2436: 2434: 2431: 2429: 2428:Methoctramine 2426: 2424: 2423:Methantheline 2421: 2419: 2416: 2414: 2411: 2409: 2406: 2404: 2401: 2399: 2398:Mamba toxin 7 2396: 2394: 2393:Mamba toxin 3 2391: 2389: 2386: 2384: 2381: 2379: 2376: 2373: 2369: 2366: 2364: 2361: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2339: 2336: 2334: 2331: 2329: 2326: 2323: 2319: 2315: 2311: 2308: 2306: 2303: 2301: 2298: 2296: 2293: 2291: 2290:Fenpiverinium 2288: 2286: 2283: 2281: 2278: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2256: 2253: 2251: 2248: 2246: 2243: 2241: 2238: 2236: 2233: 2231: 2228: 2226: 2223: 2221: 2218: 2216: 2213: 2211: 2208: 2206: 2203: 2201: 2198: 2196: 2193: 2191: 2188: 2186: 2183: 2181: 2178: 2176: 2173: 2171: 2168: 2166: 2163: 2161: 2158: 2156: 2153: 2151: 2148: 2146: 2143: 2141: 2138: 2136: 2133: 2131: 2128: 2126: 2123: 2121: 2118: 2116: 2113: 2111: 2108: 2106: 2103: 2101: 2098: 2096: 2093: 2091: 2088: 2086: 2083: 2081: 2078: 2075: 2071: 2067: 2063: 2059: 2055: 2051: 2047: 2043: 2040: 2038: 2035: 2033: 2030: 2028: 2025: 2022: 2018: 2014: 2010: 2006: 2002: 1998: 1994: 1990: 1986: 1982: 1978: 1974: 1970: 1966: 1962: 1958: 1954: 1950: 1946: 1942: 1939: 1937: 1934: 1932: 1929: 1927: 1924: 1922: 1919: 1917: 1914: 1912: 1909: 1906: 1902: 1899: 1897: 1894: 1892: 1889: 1888: 1886: 1884: 1880: 1874: 1871: 1869: 1866: 1864: 1861: 1859: 1856: 1854: 1851: 1849: 1846: 1844: 1841: 1839: 1836: 1834: 1831: 1829: 1826: 1824: 1821: 1819: 1816: 1814: 1811: 1809: 1806: 1804: 1801: 1799: 1796: 1794: 1791: 1789: 1786: 1784: 1781: 1779: 1776: 1774: 1771: 1769: 1766: 1764: 1761: 1759: 1756: 1754: 1751: 1749: 1746: 1744: 1741: 1739: 1736: 1734: 1731: 1729: 1726: 1724: 1721: 1719: 1716: 1714: 1711: 1709: 1708:cis-Dioxolane 1706: 1704: 1701: 1699: 1696: 1694: 1691: 1689: 1686: 1684: 1681: 1679: 1676: 1674: 1671: 1669: 1666: 1664: 1661: 1659: 1656: 1654: 1651: 1649: 1646: 1644: 1641: 1639: 1636: 1634: 1631: 1629: 1626: 1624: 1623:Acetylcholine 1621: 1619: 1616: 1614: 1611: 1609: 1606: 1604: 1601: 1600: 1598: 1596: 1592: 1589: 1584: 1578: 1574: 1571: 1564: 1559: 1557: 1552: 1550: 1545: 1544: 1541: 1535: 1532: 1531: 1527: 1518: 1516:9780470176504 1512: 1508: 1504: 1500: 1496: 1489: 1486: 1481: 1477: 1473: 1469: 1468: 1463: 1462:Heaney, Harry 1456: 1453: 1448: 1442: 1438: 1434: 1430: 1429: 1421: 1419: 1415: 1410: 1406: 1402: 1399: 1398: 1390: 1388: 1386: 1382: 1377: 1375:9780470129630 1371: 1367: 1363: 1359: 1352: 1350: 1346: 1341: 1337: 1333: 1329: 1328: 1320: 1317: 1304: 1300: 1298:9780471160199 1294: 1290: 1286: 1285: 1277: 1275: 1271: 1258: 1254: 1252:9780471160199 1248: 1244: 1240: 1239: 1231: 1229: 1225: 1219: 1213: 1212: 1207: 1200: 1197: 1192: 1188: 1182: 1179: 1174: 1168: 1164: 1160: 1156: 1153:. Cambridge: 1152: 1145: 1142: 1139: 1134: 1131: 1128: 1127:Sigma-Aldrich 1124: 1123:1,3-Dioxolane 1119: 1116: 1109: 1105: 1102: 1101: 1097: 1095: 1089: 1085: 1083: 1079: 1075: 1074:allyl alcohol 1071: 1064: 1041: 1026: 1011: 970: 948: 947: 946: 944: 940: 936: 932: 928: 924: 920: 916: 912: 905: 899: 865: 848: 837: 821: 820: 819: 818: 817: 815: 811: 801: 797: 795: 791: 787: 783: 778: 774: 770: 762: 760: 758: 755: 751: 743: 739: 730: 726: 724: 720: 716: 712: 708: 707:acetalization 704: 700: 693: 691: 689: 685: 681: 677: 673: 669: 653: 649: 629: 625: 622: 618: 606: 599: 594: 577: 571: 525: 522: 518: 517: 511: 508: 504: 503: 500: 497: 494: 490: 489: 485: 481: 478: 474: 473: 469: 467: 462: 457: 453: 451: 450:Boiling point 448: 447: 443: 441: 440:Melting point 438: 437: 433: 431: 428: 427: 423: 421: 418: 417: 401: 398: 394: 393: 388: 379: 375: 368: 354: 344: 340: 333: 325: 321: 320:DTXSID4027284 317: 316: 314: 304: 300: 299: 295: 293: 290: 289: 282: 278: 277: 275: 273: 270: 269: 262: 258: 257: 255: 249: 245: 244: 237: 236: 234: 232: 227: 226: 222: 218: 215: 213: 211:ECHA InfoCard 208: 207: 200: 196: 195: 193: 191: 188: 187: 180: 179:ChEMBL3187281 176: 175: 173: 171: 168: 167: 160: 156: 155: 153: 151: 148: 147: 140: 136: 135: 133: 129: 124: 123: 116: 112: 111: 109: 106: 102: 101: 96: 92:Formal glycol 84: 76: 72: 67:1,3-Dioxolane 64: 60: 55: 45: 41: 36: 32: 31: 27: 19: 18:1,2-dioxolane 2910:thioridazine 2906:mesoridazine 2840:trimipramine 2836:quinupramine 2788:clomipramine 2780:butriptyline 2598:Procyclidine 2563:Piperidolate 2478:Orphenadrine 2378:Isopropamide 2363:Imidafenacin 2322:+neostigmine 2318:+indacaterol 2300:Fesoterodine 2230:Dihexyverine 2180:Cloperastine 2050:fluperlapine 2021:triprolidine 2017:propiomazine 2013:promethazine 2001:phenindamine 1818:Talsaclidine 1778:Oxotremorine 1753:Methacholine 1743:LY-2,033,298 1502: 1499:Corey, E. J. 1488: 1471: 1465: 1455: 1426: 1400: 1395: 1361: 1331: 1325: 1319: 1307:. Retrieved 1283: 1261:. Retrieved 1237: 1217: 1209: 1199: 1190: 1181: 1150: 1144: 1133: 1118: 1093: 1067: 909: 814:benzaldehyde 805: 766: 749: 742:trivial name 737: 735: 715:ketalization 698: 697: 621:heterocyclic 616: 615: 498: 465: 98:Identifiers 86:Other names 3026:Pirisudanol 2991:Cyprodenate 2971:Adafenoxate 2936:Zamifenacin 2920:+vilanterol 2876:Tropicamide 2871:Tropatepine 2856:Trimebutine 2816:lofepramine 2792:desipramine 2759:Tolterodine 2728:mirtazapine 2720:maprotiline 2702:Telenzepine 2678:Solifenacin 2653:SCH-217,443 2628:Revefenacin 2613:Propiverine 2573:Piroheptine 2568:Pirenzepine 2533:Penthienate 2418:Mepenzolate 2413:Meladrazine 2388:Hyoscyamine 2372:+salbutamol 2358:Homatropine 2343:Hexocyclium 2200:Darifenacin 2160:CAR-302,668 2155:CAR-302,537 2150:CAR-302,368 2145:CAR-302,282 2140:CAR-302,196 2135:CAR-301,060 2130:CAR-226,086 2100:Benzydamine 2080:Benactyzine 2058:+fluoxetine 2005:pheniramine 1993:mequitazine 1977:dimetindene 1961:cinnarizine 1931:Anisodamine 1905:+formoterol 1883:Antagonists 1863:WAY-132,983 1833:Vedaclidine 1803:SDZ 210-086 1798:Sabcomeline 1788:Pilocarpine 1658:Bethanechol 688:polyacetals 682:and as a co 493:Signal word 390:Properties 217:100.010.422 159:CHEBI:87597 3073:Dioxolanes 3067:Categories 2986:Citicoline 2966:Acetyl-coA 2950:Precursors 2931:Xanomeline 2812:imipramine 2800:dibenzepin 2707:Terodiline 2696:paroxetine 2692:femoxetine 2648:SCH-72,788 2643:SCH-57,790 2633:Rociverine 2528:PD-0298029 2523:PD-102,807 2503:Oxybutynin 2408:Mebeverine 2353:HL-031,120 2338:Hexbutinol 2280:Etanautine 2235:Difemerine 2215:Dexetimide 2165:Caramiphen 2120:Bornaprine 2070:tenilapine 2066:quetiapine 2054:olanzapine 1985:doxylamine 1965:clemastine 1953:captodiame 1911:Abediterol 1868:Xanomeline 1858:VU-0238429 1853:VU-0152100 1848:VU-0152099 1843:VU-0090157 1838:VU-0029767 1823:Tazomeline 1783:PD-151,832 1773:Ocvimeline 1758:Milameline 1733:LY-593,039 1698:Cevimeline 1643:Alvameline 1618:Aceclidine 1613:AC-260,584 1603:77-LH-28-1 1573:modulators 1110:References 773:protection 699:Dioxolanes 477:Pictograms 434:1.06 g/cm 420:Molar mass 281:Y57RBG19JL 190:ChemSpider 126:3D model ( 105:CAS Number 90:5-Crown-2 88:Dioxolane 24:Dioxolane 2866:Tropacine 2784:cidoxepin 2754:Tofenacin 2724:mianserin 2716:amoxapine 2638:RU-47,213 2618:Quinidine 2578:Pizotifen 2538:Pethidine 2403:Mazaticol 2383:J-104,129 2348:Himbacine 2305:Flavoxate 2250:Drofenine 2125:Camylofin 2115:Biperiden 2090:Benzilone 2046:clozapine 2027:AQ-RA 741 1997:perlapine 1989:meclizine 1949:buclizine 1936:Anisodine 1921:AF-DX 384 1916:AF-DX 250 1763:Muscarine 1738:L-689,660 1728:Itameline 1713:Clozapine 1668:Carbachol 1653:Arecoline 939:anhydrous 911:Neosporol 711:aldehydes 626:with the 617:Dioxolane 563:P403+P235 559:P370+P378 468:labelling 292:UN number 238:211-463-5 230:EC Number 3083:Solvents 3038:See also 2980:lecithin 2956:prodrugs 2926:WIN-2299 2902:loxapine 2588:Pridinol 2448:Metixene 2205:DAU-5884 2185:CS-27349 2105:Bevonium 2074:zotepine 2062:rilapine 2032:Atropine 1693:CDD-0102 1688:CDD-0098 1683:CDD-0097 1678:CDD-0078 1673:CDD-0034 1648:AQRA-741 1633:AF150(S) 1595:Agonists 1501:(eds.). 1309:June 20, 1303:Archived 1263:June 20, 1257:Archived 1098:See also 1082:carbonyl 849:→ 822:PhCH(OCH 676:peroxide 672:isomeric 668:dioxanes 459:Hazards 115:646-06-0 3093:Formals 2976:Choline 2888:(e.g., 2808:doxepin 2766:(e.g., 2714:(e.g., 2690:(e.g., 2583:Poldine 2543:pFHHSiD 2468:Nefopam 2270:EA-3834 2265:EA-3580 2260:EA-3443 2255:EA-3167 2110:BIBN 99 2044:(e.g., 1943:(e.g., 1768:NGX-267 1748:McNA343 1703:Choline 1467:Synlett 1327:Synlett 1104:Dioxane 1078:epoxide 960:COOCOCF 838:  757:agonist 719:ketones 684:monomer 680:solvent 598:what is 596: ( 430:Density 414: 381:O1CCOC1 248:PubChem 2245:Ditran 1896:4-DAMP 1873:YM-796 1638:AF267B 1582:mAChRs 1513:  1443:  1372:  1295:  1249:  1169:  992:•CO(NH 923:sporol 919:moiety 807:NaBArF 786:ketone 670:. The 624:acetal 593:verify 590:  499:Danger 374:SMILES 170:ChEMBL 57:Names 2954:(and 2684:SSRIs 1608:AC-42 1045:CO(NH 1024:COOOH 913:is a 862:NaBAr 790:ketal 748:-(+)- 721:with 619:is a 339:InChI 296:1166 261:12586 199:12066 150:ChEBI 128:JSmol 2518:PBID 2220:DIBD 1793:RS86 1628:AF30 1511:ISBN 1472:1990 1441:ISBN 1370:ISBN 1332:2007 1311:2017 1293:ISBN 1265:2017 1247:ISBN 1167:ISBN 1039:COOH 890:HOCH 744:for 736:(+)- 713:and 567:P501 551:P280 547:P243 543:P242 539:P241 535:P240 531:P233 527:P210 513:H225 272:UNII 2774:), 2060:), 1476:doi 1433:doi 1405:doi 1401:115 1336:doi 1159:doi 1125:at 750:cis 738:cis 717:of 709:of 686:in 654:(CH 630:(CH 466:GHS 308:EPA 251:CID 3069:: 2908:, 2904:, 2900:, 2896:, 2892:, 2838:, 2834:, 2830:, 2826:, 2822:, 2818:, 2814:, 2810:, 2806:, 2802:, 2798:, 2794:, 2790:, 2786:, 2782:, 2778:, 2726:, 2722:, 2718:, 2694:, 2320:, 2316:, 2072:, 2068:, 2064:, 2052:, 2048:, 2019:, 2015:, 2011:, 2007:, 2003:, 1999:, 1995:, 1991:, 1987:, 1983:, 1979:, 1975:, 1971:, 1967:, 1963:, 1959:, 1955:, 1951:, 1947:, 1505:. 1470:. 1439:. 1431:. 1417:^ 1384:^ 1360:. 1348:^ 1330:. 1301:. 1273:^ 1255:. 1227:^ 1215:; 1208:. 1189:. 1165:. 1030:CF 1015:CF 951:CF 945:. 898:OH 894:CH 759:. 725:. 690:. 642:CH 565:, 561:, 557:, 553:, 549:, 545:, 541:, 537:, 533:, 529:, 470:: 2982:) 2978:( 2958:) 2922:) 2918:( 2912:) 2842:) 2770:( 2730:) 2698:) 2374:) 2370:( 2324:) 2312:( 2076:) 2056:( 2023:) 1907:) 1903:( 1562:e 1555:t 1548:v 1519:. 1482:. 1478:: 1449:. 1435:: 1411:. 1407:: 1378:. 1342:. 1338:: 1313:. 1267:. 1222:. 1193:. 1175:. 1161:: 1059:2 1054:) 1050:2 1035:3 1020:3 1006:2 1001:) 997:2 988:2 983:O 979:2 974:H 965:3 956:3 896:2 892:2 866:4 836:O 834:2 832:H 828:2 826:) 824:2 809:4 746:L 664:2 662:O 660:4 656:2 644:2 640:2 638:O 636:2 634:) 632:2 588:N 412:2 410:O 408:6 406:H 404:3 402:C 310:) 306:( 130:) 20:.

Index

1,2-dioxolane


Preferred IUPAC name
Systematic IUPAC name
CAS Number
646-06-0
JSmol
Interactive image
ChEBI
CHEBI:87597
ChEMBL
ChEMBL3187281
ChemSpider
12066
ECHA InfoCard
100.010.422
Edit this at Wikidata
EC Number
PubChem
12586
UNII
Y57RBG19JL
UN number
CompTox Dashboard
DTXSID4027284
Edit this at Wikidata
InChI
SMILES
Chemical formula

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