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These signatures manifest themselves in specific genes that are turned on together in the tissues of some patients in many different cancer types... If these general cancer signatures are useful in breast cancer, as we proved in this challenge, then why not in other types of cancer as well? I think
265:
In the early 2000s, Anastassiou moved away from his previous work in DVDs and compression and into
Systems Biology. Anastassiou refers to his publications in engineering and signal processing as those from a "previous lifetime". Anastassiou is currently a faculty member of the Center for the
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Anastassiou was the former director of
Columbia University's Image and Advanced Television Laboratory and director of Columbia University's Genomic Information Systems Laboratory. He came to national prominence when he, with his student Fermi Wang developed the
327:
His group's submission used a model which relied on the signatures of three metagenes, which
Anastassiou's group had previously associated with several cancers. Prior to the challenge, Anastassiou had been doing research on attractor
332:, genetic signatures expressed nearly identically between different cancers. The model predicts with 76 percent accuracy which of two breast cancer patients will live longer, which is far better than any models previously available.
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that the most significant -- and exciting -- implication of our work is the hope that these signatures can be used for improved diagnostic, prognostic, and eventually, therapeutic products, applicable to multiple cancers.
902:
230:, the recipient of IBM Outstanding Innovation Award, and a National Science Foundation Presidential Young Investigator. Anastassiou is also the recipient of the Columbia University Great Teacher Award.
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for a project entitled "Computational discovery of synergistic mechanisms responsible for psychiatric disorders", aiming to discover the biological mechanisms of psychological disorders such as
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algorithm for transmitting high quality audio and video over limited bandwidth in the early 1990s. As a result of his MPEG patent, Columbia
University became the only university in the
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348:. While the results are not yet ready for clinical use, Anastassiou's group is currently working to extend these findings to predict whether patients need further treatment.
285:. The project aims to investigate genetic variations based on genome-wide association data for psychiatric disorders to elucidate genetic mechanisms behind schizophrenia and
912:
709:"Two Science Translational Medicine Reports: DREAM and Sage Bionetworks Tap into the Wisdom of the Crowd to Fight the Challenge of Breast Cancer Prognosis and Treatment"
178:
technology, a crucial technique used in all types of digital televisions, DVDs, satellite TV, HDTV, digital cable systems, computer video, and other interactive media.
296:. As of 2013, Dimitris Anastassiou holds 14 U.S. and 8 international patents, which have so far generated up to $ 100 million in revenues for Columbia University.
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In 2013, a team led by
Anastassiou won the DREAM Breast Cancer Prognosis Challenge with a genetic model that could predict cancer prognoses with 76% accuracy.
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Anastassiou has made significant advances in the areas of digital technology. His research resulted in
Columbia being the only university to hold patent in
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and clinical feature dataset. Anastassiou's team won the challenge despite being smaller and despite competing against teams from companies such as
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and recipient of both the
National Science Foundation Presidential Young Investigator Award and the IBM Outstanding Innovation Award.
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for contributions to video technology, developing high-performance digital image and video coding techniques . He is also a
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patent pool. Revenue from the patent pool allowed
Anastassiou to pursue interdisciplinary research in other areas.
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A Lever Long Enough: A History of
Columbia's School of Engineering and Applied Science Since 1864
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The research for the competition was partially funded by
Anastassiou's patents in DVD encoding.
769:"Development of a Prognostic Model for Breast Cancer Survival in an Open Challenge Environment"
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In 2013, a team led by Anastassiou won the Breast Cancer Prognosis Challenge (BCC), run by
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Between 1979 and 1983, Dimitris Anastassiou was a Research Staff member at the IBM
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Dimitris Anastassiou is widely recognized in the engineering community. He is an
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155:. His more recent work involves interdisciplinary research, specifically in
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Cheng, Wei-Yi; Yang, Tai-Hsien Ou; Anastassiou, Dimitris (17 April 2013).
324:, by taking an approach that was "out-of-the-box" and "completely novel".
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software. In 1983, Anastassiou joined the faculty of Columbia University.
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687:"National Academy of Inventors Taps Prof. Anastassiou as New Fellow"
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Anastassiou, Dimitris (June 1996). "High Definition Television".
241:, NY. While at IBM, Anastassiou worked on the development of IBM
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Columbia Fu Foundation School of Engineering and Applied Science
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312:(DREAM), which challenged teams to develop models to predict
434:"New Computational Model Can Predict Breast Cancer Survival"
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Columbia School of Engineering and Applied Science faculty
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Dialogue for Reverse Engineering Assessments and Methods
839:"Breast Cancer: 'Geek Sandbox' Holds Clues to Survival"
381:"IEEE Fellows 1998 | IEEE Communications Society"
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Multiscale Analysis of Genomic and Cellular Networks.
292:
In 2013, Anastassiou was inducted as a Fellow of the
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In 2009, Anastassiou won an $ 800,000 award from the
209:, Anastassiou earned M.S. and Ph.D. degrees from the
813:"Breast Cancer Survival Predicted By Computer Model"
586:. New York: Columbia University Press. p. 198.
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The findings from the competition were published in
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147:. Anastassiou's earlier work focuses primarily on
635:"Dean Feniosky Peña-Mora's Convocation Address"
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908:National Technical University of Athens alumni
405:"A new way to predict breast cancer survival"
8:
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403:Moore, Elizabeth Armstrong (18 April 2013).
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169:Fellow of the National Academy of Inventors
143:Professor of Electrical Engineering in the
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913:UC Berkeley College of Engineering alumni
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145:Columbia University School of Engineering
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608:"Modern Greece: Science and Technology"
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261:Transition to systems biology (2000s)
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938:Greek emigrants to the United States
222:Electrical engineering (1979-1990s)
811:Rettner, Rachael (17 April 2013).
664:"Prof. Anastassiou Wins NIH Award"
335:Of the results, Anastassiou said:
279:Columbia University Medical Center
211:University of California, Berkeley
161:Columbia University Medical Center
69:University of California, Berkeley
14:
610:. Hellenica World. Archived from
300:Breast Cancer Prognosis Challenge
149:signal and information processing
556:"Dimitris Anastassiou Biography"
316:survival rates based on a large
235:Thomas J. Watson Research Center
873:Columbia Engineering Newsletter
715:. 17 April 2013. Archived from
773:Science Translational Medicine
346:Science Translational Medicine
139:is an electrical engineer and
1:
741:Swartz, Aimee (4 June 2013).
455:McCarthy, Nicola (May 2013).
294:National Academy of Inventors
868:Columbia Engineering Faculty
786:10.1126/scitranslmed.3005974
511:IEEE Communications Magazine
271:National Institute of Health
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933:Greek electrical engineers
582:McCaughey, Robert (2014).
457:"Rising to the challenge"
197:in 1952. He received his
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743:"May the Best Model Win"
523:10.1109/MCOM.1996.506817
189:Anastassiou was born in
185:Early life and education
159:, with investigators at
199:Bachelor of Engineering
689:. Columbia Engineering
666:. Columbia Engineering
633:Peña-Moras, Feniosky.
558:. Columbia Engineering
436:. Columbia Engineering
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111:Biomedical Engineering
107:Electrical Engineering
928:Engineers from Athens
641:. Columbia University
461:Nature Reviews Cancer
205:. Upon moving to the
639:Columbia Engineering
137:Dimitris Anastassiou
23:Dimitris Anastassiou
898:Fellows of the IEEE
685:Farmer, Melanie A.
153:reverse engineering
125:Columbia University
361:Digital Technology
165:Fellow of the IEEE
845:. The Gupta Guide
837:Laino, Charlene.
275:Maria Karayiorgou
163:. Anastassiou is
141:Charles Batchelor
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97:Scientific career
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367:References
81:technology
491:205469727
330:metagenes
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355:See also
55:American
843:MedPage
713:Reuters
255:MPEG LA
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251:MPEG-2
217:Career
195:Greece
191:Athens
176:MPEG-2
103:Fields
86:Awards
79:MPEG-2
40:Greece
36:Athens
527:S2CID
487:S2CID
51:Greek
851:2016
824:2016
791:PMID
754:2016
725:2016
695:2016
672:2016
647:2016
620:2016
588:ISBN
564:2016
479:PMID
442:2016
416:2016
409:CNET
308:and
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29:Born
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