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Tenofovir alafenamide

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692: 36: 78: 826: 995:(Stribild) to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (Genvoya), the results showed the newer drug's effects to be non-inferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval. 4223: 4211: 1344: 2410: 2386: 1348: 2400: 2500: 3018: 768: 2382: 2019: 1372: 2508: 1436: 377: 810:
InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
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Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (Symtuza) — approved in the European Union in September 2017, in the United States in July 2018, and in Australia in November 2019.
3153: 1406: 1345:"U.S. Food and Drug Administration Approves Gilead's Single Tablet Regimen Genvoya (Elvitegravir, Cobicistat, Emtricitabine and Tenofovir Alafenamide) for Treatment of HIV-1 Infection" 2625: 3592: 1367: 282: 2789: 2324: 2294: 1591: 2202: 1849: 2112: 2082: 2007: 1985: 1955: 1760: 1697: 1466: 1171: 2401:"Gilead Sciences Finalizes Agreement with Tibotec Pharmaceuticals to Develop and Commercialize a Single-Tablet Regimen of Prezista with Emtriva, GS 7340 and Cobicistat" 4248: 3159: 1100: 3217: 3137: 2357: 947: 923: 3222: 1362: 3170: 2571: 922:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (Genvoya) — approved both in the United States and in the European Union in November 2015, (compare
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Emtricitabine/rilpivirine/tenofovir alafenamide (Odefsey) — approved in the United States in March 2016, and in the European Union in June 2016, (compare
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GS-7340 demonstrates greater declines in HIV-1 RNA than tenofovir disoproxil fumarate during 14 days of monotherapy in HIV-1 infected subjects
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Eisenberg EJ, He GX, Lee WA (2001). "Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood".
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Childs-Kean LM, Egelund EF, Jourjy J (October 2018). "Tenofovir Alafenamide for the Treatment of Chronic Hepatitis B Monoinfection".
4278: 3691: 2783: 2564: 985: 802: 2198: 1042: 3237: 3121: 231: 2531: 2104: 2074: 1977: 1947: 1752: 1689: 1458: 1163: 4051: 4014: 3247: 3232: 3012: 2992: 2910: 2895: 2883: 485: 362: 212: 3127: 2455: 1136: 896: 4201: 2549: 2346: 3624: 2557: 2383:"Gilead Initiates Phase 3 Clinical Program for Tenofovir Alafenamide, a Novel Low-Dose Prodrug for the Treatment of HIV" 2353: 2288: 2140: 2013: 1918: 1883: 1788: 1660: 1625: 1529: 1494: 1400: 904: 591: 4243: 4182: 3580: 969: 671: 1620:"Drug Approval Package: Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate) Fixed Dose" 1075: 1877: 1911: 1653: 1522: 4268: 4258: 2134: 1821: 1782: 1724: 1619: 1563: 1488: 1198: 903:
than that agent. It was approved for use in the US for HIV in 2015, and for hepatitis B in 2016. Although the US
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and is given in combination with other medications for the prevention and treatment of HIV. It is taken
2441: 2008:"FDA approves second drug to prevent HIV infection as part of ongoing efforts to end the HIV epidemic" 204: 4061: 3918: 3148: 2997: 2755: 2485: 936:
Emtricitabine/tenofovir alafenamide (Descovy) — approved in the United States in April 2016 (compare
454: 687: 4047: 4010: 3762: 3257: 3116: 2988: 2906: 2705: 2584: 865: 506: 275: 77: 2135:"Drug Approval Package: Symtuza (darunavir, cobicistat, emtricitabine, and tenofovir alafenamide)" 825: 4112: 2047: 1294: 1251: 908: 242: 1429:"Gilead settles 5 more Descovy patent feuds, pushing copycats to its PrEP successor out to 2031" 3545: 3540: 3399: 3062: 2501:"CROI 2013: New Pro-drug Tenofovir Alafenamide Appears Equally Effective but Better Tolerated" 2105:"Symtuza- darunavir, cobicistat, emtricitabine, and tenofovir alafenamide tablet, film coated" 1878:"Drug Approval Package: (emtricitabine/rilpivirine/tenofovir disoproxil fumarate) NDA #202123" 1286: 1243: 640: 414: 401: 389: 176: 1719: 1012: 580: 3424: 2168: 1816: 1558: 1278: 1235: 1193: 708: 515: 436: 95: 600: 4215: 3939: 3701: 3500: 3459: 2619: 2405: 1312:
Markowitz M, Zolopa A, Ruane P, Squires K, Zhong L, Kearney BP, et al. (March 2011).
900: 884: 691: 2075:"Biktarvy- bictegravir sodium, emtricitabine, and tenofovir alafenamide fumarate tablet" 49:
Please help update this article to reflect recent events or newly available information.
4227: 4176: 3958: 3728: 3643: 3574: 3350: 3332: 3295: 2580: 2255:"Drug and medical device highlights 2018: Helping you maintain and improve your health" 972:
clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide with
69: 4237: 4094: 3893: 3673: 3340: 3090: 2925: 2811: 2539: 2259: 1854: 1753:"Odefsey- emtricitabine, rilpivirine hydrochloride, and tenofovir alafenamide tablet" 1596: 1105: 977: 861: 1459:"Genvoya- elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide tablet" 1298: 1255: 540: 4133: 3904: 3781: 3719: 3655: 3651: 3647: 3394: 3384: 2965: 2955: 2773: 2730: 2725: 2720: 2682: 2662: 2592: 981: 940:; (Truvada)). In October 2019, Descovy was approved in the United States for HIV-1 345: 340: 335: 330: 325: 320: 315: 310: 305: 300: 295: 290: 1043:"Prescription medicines: registration of new chemical entities in Australia, 2016" 2347:"Tentative Approval: Dolutegravir, Lamivudine, and Tenofovir Alafenamide Tablets" 984:
and developed a coformulation of the drug with cobicistat, emtricitabine and the
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technology of Chris McGuigan and is applied in the form of tenofovir alafenamide
4142: 4034: 4000: 3986: 3981: 3776: 3737: 3733: 3724: 3520: 3495: 3434: 3419: 3414: 3078: 3045: 2960: 2940: 2735: 2715: 2694: 2641: 2609: 1363:"FDA Approves Vemlidy (tenofovir alafenamide) for Chronic Hepatitis B in Adults" 1128: 857: 849: 2463: 1129:"Vemlidy 25 mg film coated tablets - Summary of Product Characteristics (SmPC)" 4147: 4104: 4024: 3973: 3963: 3934: 3898: 3882: 3872: 3831: 3816: 3751: 3525: 3505: 3490: 3485: 3449: 3444: 3358: 3303: 3273: 3085: 3073: 3068: 3040: 2980: 2970: 2945: 2930: 2920: 2869: 2864: 2852: 2836: 2826: 2806: 2768: 2678: 2666: 2658: 1321:. 18th Conference on Retroviruses and Opportunistic Infections. Archived from 1074:. Government of Canada: The Drug and Health Product Register. 20 August 2020. 973: 744: 571: 4138: 4089: 4039: 4029: 4019: 3930: 3887: 3877: 3852: 3806: 3791: 3715: 3640: 3535: 3515: 3510: 3480: 3409: 3389: 3322: 3278: 3035: 2950: 2935: 2858: 2831: 2821: 2816: 2763: 2740: 2653: 988: 895:(TAF). Closely related to the commonly used reverse-transcriptase inhibitor 880: 845: 467: 198: 2434:"GS-7340 Packs Greater HIV Punch, Potentially Better Safety, Versus Viread" 1290: 1247: 1282: 1068: 4056: 3949: 3826: 3530: 2915: 1783:"Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide) Tablets" 892: 830: 551: 226: 2456:"Pharmacokinetics of a Novel EVG/COBI/FTC/GS-7340 Single Tablet Regimen" 560: 3800: 3771: 3746: 3710: 3598: 3429: 2975: 2745: 899:(TDF), TAF has greater antiviral activity and better distribution into 888: 876: 526: 4222: 1239: 3811: 3379: 3374: 651: 2460:
13th International Workshop on Clinical Pharmacology of HIV Therapy
620: 2689: 2478:"Once-Daily Tenofovir Prodrug Combo Pill as Effective as Stribild" 2043:"F.D.A. Approves New H.I.V.-Prevention Drug, but Not for Everyone" 824: 767: 758: 631: 2648: 2636: 611: 420: 395: 3613: 2553: 2532:"Tenefovir Alafenamide Fumarate (TAF) Sign-On Letter to Gilead" 408: 221: 2673: 2588: 907:(FDA) has approved tenofovir alafenamide for manufacture as a 853: 125: 29: 2199:"TGA eBS - Product and Consumer Medicine Information Licence" 1069:"Product Monograph: Vemlidy (tenofovir alafenamide) tablets" 950:(Biktarvy) — approved in the United States in February 2018. 676: 3203:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
790:
C(CN1C=NC2=C(N=CN=C21)N)OC(=O)(N(C)C(=O)OC(C)C)OC3=CC=CC=C3
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Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
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elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
1978:"Descovy- emtricitabine and tenofovir alafenamide tablet" 133: 3154:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
1592:"Health Canada New Drug Authorizations: 2015 Highlights" 1347:(Press release). Gilead. 5 November 2015. Archived from 915:
Fixed-dose combinations containing tenofovir alafenamide
384: 1465:. U.S. National Library of Medicine. 11 February 2019. 1170:. U.S. National Library of Medicine. 11 February 2020. 1984:. U.S. National Library of Medicine. 13 January 2020. 1954:. U.S. National Library of Medicine. 9 December 2019. 1759:. U.S. National Library of Medicine. 6 December 2019. 1696:. U.S. National Library of Medicine. 28 January 2019. 1013:"Tenofovir alafenamide (Vemlidy) Use During Pregnancy" 4199: 1368:
United States Department of Health and Human Services
151: 145: 130: 116: 110: 98: 2081:. U.S. National Library of Medicine. 8 August 2019. 163: 136: 122: 101: 4126: 4103: 4082: 4075: 3999: 3972: 3948: 3917: 3865: 3845: 3761: 3700: 3690: 3681: 3672: 3663: 3473: 3367: 3349: 3331: 3313: 3294: 3287: 3266: 3107: 3054: 3028: 3011: 2894: 2882: 2845: 2799: 2782: 2754: 2704: 2618: 2600: 2111:. U.S. National Library of Medicine. 6 March 2020. 1158: 1156: 1154: 756: 743: 707: 702: 670: 650: 630: 610: 590: 570: 550: 525: 505: 476: 466: 453: 443: 435: 361: 356: 281: 267: 241: 211: 193: 185: 175: 157: 142: 107: 89: 84: 4264:Nucleoside analog reverse transcriptase inhibitors 956:Dolutegravir/emtricitabine/tenofovir alafenamide. 3160:Dolutegravir/emtricitabine/tenofovir alafenamide 539: 18:Dolutegravir/emtricitabine/tenofovir alafenamide 3218:Emtricitabine/rilpivirine/tenofovir alafenamide 3138:Bictegravir/emtricitabine/tenofovir alafenamide 948:Bictegravir/emtricitabine/tenofovir alafenamide 924:elvitegravir/cobicistat/emtricitabine/tenofovir 514: 3223:Emtricitabine/rilpivirine/tenofovir disoproxil 2709:(Integrase strand transfer inhibitors (INSTI)) 2462:. Barcelona, Spain. April 2012. Archived from 959:Dolutegravir/lamivudine/tenofovir alafenamide. 497:)-2-methyl-phenoxy-phosphoryl]amino]propanoate 3625: 3171:Dolutegravir/lamivudine/tenofovir alafenamide 2565: 8: 3193:Efavirenz/emtricitabine/tenofovir disoproxil 3177:Dolutegravir/lamivudine/tenofovir disoproxil 230: 68: 428:In general: ℞ (Prescription only) 4079: 3697: 3687: 3678: 3669: 3632: 3618: 3610: 3291: 3188:Doravirine/lamivudine/tenofovir disoproxil 3025: 2891: 2796: 2572: 2558: 2550: 2385:(Press release). Gilead. 24 January 2013. 873:nucleotide reverse transcriptase inhibitor 690: 579: 3198:Efavirenz/lamivudine/tenofovir disoproxil 1339: 1337: 1335: 599: 3465:Zinc finger protein transcription factor 4249:Fixed dose combination (antiretroviral) 4206: 1164:"Vemlidy- tenofovir alafenamide tablet" 1004: 807: 787: 686: 559: 490: 1047:Therapeutic Goods Administration (TGA) 67: 2389:from the original on 11 October 2019. 2235:from the original on 20 February 2022 2205:from the original on 20 February 2022 1271:Nucleosides Nucleotides Nucleic Acids 659: 639: 203: 7: 2413:from the original on 11 October 2019 2022:from the original on 11 October 2019 1375:from the original on 11 October 2019 833:, the salt used in drug formulations 344: 334: 324: 314: 304: 294: 3213:Emtricitabine/tenofovir alafenamide 2409:(Press release). 15 November 2011. 1395:"First Generic Drug Approvals 2023" 931:Emtricitabine/rilpivirine/tenofovir 619: 530: 3228:Emtricitabine/tenofovir disoproxil 2085:from the original on 1 August 2020 1797:from the original on 13 April 2021 1763:from the original on 1 August 2020 1572:from the original on 8 August 2020 1469:from the original on 1 August 2020 856:. It is used for the treatment of 737: 25: 2484:. 1 November 2012. Archived from 2327:from the original on 2 April 2022 2179:from the original on 10 July 2021 1988:from the original on 24 June 2021 1958:from the original on 29 July 2020 1928:from the original on 1 April 2021 1892:from the original on 29 July 2020 1830:from the original on 29 July 2020 1733:from the original on 29 July 2020 1700:from the original on 29 July 2020 1670:from the original on 29 July 2020 1634:from the original on 29 July 2020 1539:from the original on 29 July 2020 1503:from the original on 29 July 2020 1439:from the original on 30 June 2023 1409:from the original on 30 June 2023 1207:from the original on 13 July 2021 1139:from the original on 11 July 2021 1081:from the original on 10 June 2022 4221: 4209: 3601:. Formerly or rarely used agent. 3238:Lamivudine/nevirapine/zidovudine 3122:Abacavir/dolutegravir/lamivudine 2297:from the original on 9 July 2021 2225:"Symtuza 800/150/200/10 Tablets" 2149:from the original on 9 July 2021 2115:from the original on 9 July 2021 2055:from the original on 9 July 2021 1174:from the original on 9 July 2021 1023:from the original on 9 July 2021 725: 719: 94: 76: 34: 3405:Epigallocatechin gallate (EGCG) 3248:Lamivudine/tenofovir disoproxil 3233:Lamivudine/nevirapine/stavudine 2363:from the original on 7 May 2022 2317:"Drugs@FDA: FDA-Approved Drugs" 2283:"Drugs@FDA: FDA-Approved Drugs" 2041:Mandavilli A (4 October 2019). 991:. In a 48-week study comparing 860:(HBV) infection in adults with 815:Key:LDEKQSIMHVQZJK-CAQYMETFSA-N 3128:Abacavir/lamivudine/zidovudine 731: 713: 1: 2499:Highleyman L (6 March 2013). 897:tenofovir disoproxil fumarate 472:Feces (31.7%), urine (<1%) 2354:Food and Drug Administration 2289:Food and Drug Administration 2141:Food and Drug Administration 2014:Food and Drug Administration 1919:Food and Drug Administration 1884:Food and Drug Administration 1789:Food and Drug Administration 1661:Food and Drug Administration 1626:Food and Drug Administration 1530:Food and Drug Administration 1495:Food and Drug Administration 1401:Food and Drug Administration 905:Food and Drug Administration 840:, sold under the brand name 3003:Tenofovir alafenamide (TAF) 871:Tenofovir alafenamide is a 4295: 2998:Tenofovir disoproxil (TDF) 1912:"Summary Review: Complera" 1654:"Summary Review: Stribild" 703:Chemical and physical data 299:) Combination codes: 4160: 3558: 3019:Discovery and development 2790:Discovery and development 2626:Discovery and development 2173:European Medicines Agency 1822:European Medicines Agency 1725:European Medicines Agency 1564:European Medicines Agency 1523:"Summary Review: Genvoya" 1199:European Medicines Agency 862:compensated liver disease 858:chronic hepatitis B virus 798: 778: 481: 75: 43:This article needs to be 4279:Pre-exposure prophylaxis 3315:Transcription inhibitors 3267:Pharmacokinetic boosters 3183:Dolutegravir/rilpivirine 3144:Cabotegravir/rilpivirine 2784:Protease Inhibitors (PI) 2432:Horn T (15 March 2012). 942:pre-exposure prophylaxis 848:medication used against 4083:Nucleic acid inhibitors 3599:initial regimen options 3165:Dolutegravir/lamivudine 2642:Enfuvirtide (ENF, T-20) 2620:Entry/fusion inhibitors 2530:Horn T (13 June 2013). 938:emtricitabine/tenofovir 911:, it is not available. 3440:Portmanteau inhibitors 3333:Translation inhibitors 3243:Lamivudine/raltegravir 3013:Non-nucleoside (NNRTI) 2971:Islatravir (EFdA, ISL) 2536:Treatment Action Group 1850:"Immune system health" 883:. It was developed by 834: 829:Tenofovir alafenamide 4118:Peginterferon alfa-2a 4067:Tenofovir alafenamide 3455:Synergistic enhancers 3253:Lamivudine/zidovudine 3133:Atazanavir/cobicistat 3109:Combined formulations 2946:Zidovudine (AZT, ZDV) 2884:Reverse-transcriptase 2756:Maturation inhibitors 2488:on 20 September 2015. 2175:. 17 September 2018. 1826:. 17 September 2018. 1729:. 17 September 2018. 1568:. 17 September 2018. 1435:. 12 September 2022. 1283:10.1081/NCN-100002496 1203:. 17 September 2018. 838:Tenofovir alafenamide 828: 232:Tenofovir alafenamide 70:Tenofovir alafenamide 4062:Tenofovir disoproxil 4048:Nucleotide analogues 4011:Nucleoside analogues 3296:Uncoating inhibitors 3149:Darunavir/cobicistat 2989:Nucleotide analogues 2907:Nucleoside analogues 2706:Integrase inhibitors 2585:antiretroviral drugs 2542:on 19 November 2019. 2466:on 28 November 2020. 2444:on 8 September 2015. 2145:. 11 December 2018. 1888:. 6 September 2012. 1793:. 29 November 2016. 1371:. 21 November 2016. 1135:. 8 September 2020. 1019:. 26 December 2018. 3763:Pyrimidine analogue 3288:Experimental agents 3258:Lopinavir/ritonavir 3117:Abacavir/lamivudine 3091:Elsulfavirine (ESV) 2926:Emtricitabine (FTC) 2812:Fosamprenavir (FPV) 2505:hivandhepatitis.com 1663:. 19 October 2015. 1630:. 10 October 2012. 1499:. 8 December 2015. 1351:on 8 November 2015. 968:Gilead announced a 404:(Prescription only) 380:(Prescription only) 72: 4244:Carboxylate esters 4187:Never to phase III 4113:Interferon alfa 2b 3585:Never to phase III 2731:Elvitegravir (EVG) 2726:Dolutegravir (DTG) 2721:Cabotegravir (CAB) 2511:on 25 October 2020 2321:accessdata.fda.gov 2048:The New York Times 2018:. 3 October 2019. 986:protease inhibitor 909:generic medication 835: 4197: 4196: 4156: 4155: 3995: 3994: 3913: 3912: 3861: 3860: 3841: 3840: 3607: 3606: 3554: 3553: 3400:Diarylpyrimidines 3103: 3102: 3099: 3098: 3079:Rilpivirine (RPV) 3063:diarylpyrimidines 3046:Delavirdine (DLV) 2941:Zalcitabine (ddC) 2898:nucleotide (NRTI) 2878: 2877: 2736:Raltegravir (RAL) 2716:Bictegravir (BIC) 2695:Fostemsavir (FTR) 2610:Lenacapavir (LEN) 2602:Capsid inhibitors 2356:. 30 March 2022. 2263:. 14 October 2020 1532:. 6 August 2012. 1328:on 25 April 2012. 1240:10.1002/phar.2174 1234:(10): 1051–1057. 823: 822: 769:Interactive image 672:CompTox Dashboard 424: 412: 399: 387: 375: 257: 224: 64: 63: 27:Chemical compound 16:(Redirected from 4286: 4269:Organophosphates 4259:Isopropyl esters 4226: 4225: 4214: 4213: 4212: 4205: 4127:Multiple/unknown 4080: 4076:Multiple/general 3846:Not TK activated 3698: 3688: 3679: 3670: 3634: 3627: 3620: 3611: 3425:Hydroxycarbamide 3292: 3086:Doravirine (DOR) 3074:Etravirine (ETR) 3069:Dapivirine (DPV) 3041:Nevirapine (NVP) 3026: 2931:Lamivudine (3TC) 2921:Didanosine (ddI) 2892: 2865:Tipranavir (TPV) 2853:Atazanavir (ATV) 2837:Saquinavir (SQV) 2827:Nelfinavir (NFV) 2807:Amprenavir (APV) 2797: 2679:Ibalizumab (IBA) 2574: 2567: 2560: 2551: 2544: 2543: 2538:. Archived from 2527: 2521: 2520: 2518: 2516: 2507:. Archived from 2496: 2490: 2489: 2474: 2468: 2467: 2452: 2446: 2445: 2440:. Archived from 2429: 2423: 2422: 2420: 2418: 2397: 2391: 2390: 2379: 2373: 2372: 2370: 2368: 2362: 2351: 2343: 2337: 2336: 2334: 2332: 2313: 2307: 2306: 2304: 2302: 2279: 2273: 2272: 2270: 2268: 2251: 2245: 2244: 2242: 2240: 2231:. 15 July 2021. 2229:NPS MedicineWise 2221: 2215: 2214: 2212: 2210: 2195: 2189: 2188: 2186: 2184: 2165: 2159: 2158: 2156: 2154: 2131: 2125: 2124: 2122: 2120: 2101: 2095: 2094: 2092: 2090: 2071: 2065: 2064: 2062: 2060: 2038: 2032: 2031: 2029: 2027: 2004: 1998: 1997: 1995: 1993: 1974: 1968: 1967: 1965: 1963: 1944: 1938: 1937: 1935: 1933: 1927: 1921:. 19 July 2011. 1916: 1908: 1902: 1901: 1899: 1897: 1874: 1868: 1867: 1865: 1863: 1846: 1840: 1839: 1837: 1835: 1813: 1807: 1806: 1804: 1802: 1779: 1773: 1772: 1770: 1768: 1749: 1743: 1742: 1740: 1738: 1716: 1710: 1709: 1707: 1705: 1686: 1680: 1679: 1677: 1675: 1669: 1658: 1650: 1644: 1643: 1641: 1639: 1616: 1610: 1609: 1607: 1605: 1588: 1582: 1581: 1579: 1577: 1555: 1549: 1548: 1546: 1544: 1538: 1527: 1519: 1513: 1512: 1510: 1508: 1485: 1479: 1478: 1476: 1474: 1455: 1449: 1448: 1446: 1444: 1425: 1419: 1418: 1416: 1414: 1391: 1385: 1384: 1382: 1380: 1359: 1353: 1352: 1341: 1330: 1329: 1327: 1320: 1309: 1303: 1302: 1266: 1260: 1259: 1223: 1217: 1216: 1214: 1212: 1190: 1184: 1183: 1181: 1179: 1160: 1149: 1148: 1146: 1144: 1125: 1119: 1118: 1116: 1114: 1097: 1091: 1090: 1088: 1086: 1080: 1073: 1065: 1059: 1058: 1056: 1054: 1039: 1033: 1032: 1030: 1028: 1009: 901:lymphoid tissues 771: 751: 739: 733: 727: 721: 715: 695: 694: 680: 678: 663: 643: 623: 603: 583: 563: 543: 533: 532: 518: 458: 422: 419: 410: 407: 397: 394: 386: 383: 373: 370: 348: 338: 328: 318: 308: 298: 255: 252: 234: 223: 220: 207: 170: 169: 166: 165: 162: 159: 156: 153: 150: 147: 144: 141: 138: 135: 132: 128: 127: 124: 121: 118: 115: 112: 109: 106: 103: 100: 80: 73: 71: 59: 56: 50: 38: 37: 30: 21: 4294: 4293: 4289: 4288: 4287: 4285: 4284: 4283: 4254:Gilead Sciences 4234: 4233: 4232: 4220: 4210: 4208: 4200: 4198: 4193: 4192: 4177:Clinical trials 4152: 4122: 4099: 4071: 3991: 3968: 3944: 3940:Podophyllotoxin 3909: 3857: 3837: 3757: 3702:Purine analogue 3683: 3659: 3638: 3608: 3603: 3602: 3590: 3575:Clinical trials 3550: 3501:Dexelvucitabine 3469: 3460:Tre recombinase 3363: 3345: 3327: 3323:Tat antagonists 3309: 3283: 3262: 3095: 3050: 3036:Efavirenz (EFV) 3015: 3007: 2936:Stavudine (d4T) 2897: 2885: 2874: 2859:Darunavir (DRV) 2841: 2832:Ritonavir (RTV) 2822:Lopinavir (LPV) 2817:Indinavir (IDV) 2786: 2778: 2750: 2708: 2700: 2654:Maraviroc (MVC) 2622: 2614: 2596: 2581:Antiviral drugs 2578: 2548: 2547: 2529: 2528: 2524: 2514: 2512: 2498: 2497: 2493: 2476: 2475: 2471: 2454: 2453: 2449: 2431: 2430: 2426: 2416: 2414: 2406:Gilead Sciences 2399: 2398: 2394: 2381: 2380: 2376: 2366: 2364: 2360: 2349: 2345: 2344: 2340: 2330: 2328: 2315: 2314: 2310: 2300: 2298: 2281: 2280: 2276: 2266: 2264: 2253: 2252: 2248: 2238: 2236: 2223: 2222: 2218: 2208: 2206: 2197: 2196: 2192: 2182: 2180: 2167: 2166: 2162: 2152: 2150: 2133: 2132: 2128: 2118: 2116: 2103: 2102: 2098: 2088: 2086: 2073: 2072: 2068: 2058: 2056: 2040: 2039: 2035: 2025: 2023: 2006: 2005: 2001: 1991: 1989: 1976: 1975: 1971: 1961: 1959: 1946: 1945: 1941: 1931: 1929: 1925: 1914: 1910: 1909: 1905: 1895: 1893: 1876: 1875: 1871: 1861: 1859: 1848: 1847: 1843: 1833: 1831: 1815: 1814: 1810: 1800: 1798: 1781: 1780: 1776: 1766: 1764: 1751: 1750: 1746: 1736: 1734: 1720:"Stribild EPAR" 1718: 1717: 1713: 1703: 1701: 1688: 1687: 1683: 1673: 1671: 1667: 1656: 1652: 1651: 1647: 1637: 1635: 1618: 1617: 1613: 1603: 1601: 1590: 1589: 1585: 1575: 1573: 1557: 1556: 1552: 1542: 1540: 1536: 1525: 1521: 1520: 1516: 1506: 1504: 1487: 1486: 1482: 1472: 1470: 1457: 1456: 1452: 1442: 1440: 1427: 1426: 1422: 1412: 1410: 1405:. 30 May 2023. 1393: 1392: 1388: 1378: 1376: 1361: 1360: 1356: 1343: 1342: 1333: 1325: 1318: 1311: 1310: 1306: 1277:(4–7): 1091–8. 1268: 1267: 1263: 1228:Pharmacotherapy 1225: 1224: 1220: 1210: 1208: 1192: 1191: 1187: 1177: 1175: 1162: 1161: 1152: 1142: 1140: 1127: 1126: 1122: 1112: 1110: 1101:"Liver disease" 1099: 1098: 1094: 1084: 1082: 1078: 1071: 1067: 1066: 1062: 1052: 1050: 1041: 1040: 1036: 1026: 1024: 1011: 1010: 1006: 1001: 966: 917: 885:Gilead Sciences 819: 816: 811: 806: 805: 794: 791: 786: 785: 774: 749: 736: 730: 724: 718: 698: 674: 666: 646: 626: 606: 586: 566: 546: 529: 521: 501: 498: 489: 488: 456: 445:Protein binding 437:Pharmacokinetic 431: 352: 270: 263: 244: 237: 129: 97: 93: 60: 54: 51: 48: 39: 35: 28: 23: 22: 15: 12: 11: 5: 4292: 4290: 4282: 4281: 4276: 4271: 4266: 4261: 4256: 4251: 4246: 4236: 4235: 4231: 4230: 4218: 4195: 4194: 4191: 4190: 4189: 4188: 4185: 4174: 4168: 4162: 4161: 4158: 4157: 4154: 4153: 4151: 4150: 4145: 4136: 4130: 4128: 4124: 4123: 4121: 4120: 4115: 4109: 4107: 4101: 4100: 4098: 4097: 4092: 4086: 4084: 4077: 4073: 4072: 4070: 4069: 4064: 4059: 4043: 4042: 4037: 4032: 4027: 4022: 4006: 4004: 3997: 3996: 3993: 3992: 3990: 3989: 3984: 3978: 3976: 3970: 3969: 3967: 3966: 3954: 3952: 3946: 3945: 3943: 3942: 3937: 3927: 3925: 3915: 3914: 3911: 3910: 3908: 3907: 3902: 3890: 3885: 3880: 3875: 3869: 3867: 3863: 3862: 3859: 3858: 3856: 3855: 3849: 3847: 3843: 3842: 3839: 3838: 3836: 3835: 3822: 3821: 3820: 3819: 3814: 3809: 3796: 3795: 3789: 3779: 3767: 3765: 3759: 3758: 3756: 3755: 3742: 3741: 3731: 3729:Valganciclovir 3722: 3706: 3704: 3695: 3685: 3676: 3667: 3661: 3660: 3639: 3637: 3636: 3629: 3622: 3614: 3605: 3604: 3589: 3588: 3587: 3586: 3583: 3572: 3566: 3560: 3559: 3556: 3555: 3552: 3551: 3549: 3548: 3543: 3538: 3533: 3528: 3523: 3518: 3513: 3508: 3503: 3498: 3493: 3488: 3483: 3477: 3475: 3471: 3470: 3468: 3467: 3462: 3457: 3452: 3447: 3442: 3437: 3432: 3427: 3422: 3417: 3412: 3407: 3402: 3397: 3392: 3387: 3382: 3377: 3371: 3369: 3365: 3364: 3362: 3361: 3355: 3353: 3347: 3346: 3344: 3343: 3337: 3335: 3329: 3328: 3326: 3325: 3319: 3317: 3311: 3310: 3308: 3307: 3300: 3298: 3289: 3285: 3284: 3282: 3281: 3276: 3274:Cobicistat (c) 3270: 3268: 3264: 3263: 3261: 3260: 3255: 3250: 3245: 3240: 3235: 3230: 3225: 3220: 3215: 3210: 3205: 3200: 3195: 3190: 3185: 3180: 3174: 3168: 3162: 3157: 3151: 3146: 3141: 3135: 3130: 3125: 3119: 3113: 3111: 3105: 3104: 3101: 3100: 3097: 3096: 3094: 3093: 3088: 3083: 3082: 3081: 3076: 3071: 3058: 3056: 3052: 3051: 3049: 3048: 3043: 3038: 3032: 3030: 3023: 3009: 3008: 3006: 3005: 3000: 2984: 2983: 2978: 2973: 2968: 2963: 2958: 2953: 2948: 2943: 2938: 2933: 2928: 2923: 2918: 2916:Abacavir (ABC) 2902: 2900: 2896:Nucleoside and 2889: 2880: 2879: 2876: 2875: 2873: 2872: 2867: 2862: 2856: 2849: 2847: 2843: 2842: 2840: 2839: 2834: 2829: 2824: 2819: 2814: 2809: 2803: 2801: 2794: 2780: 2779: 2777: 2776: 2771: 2766: 2760: 2758: 2752: 2751: 2749: 2748: 2743: 2738: 2733: 2728: 2723: 2718: 2712: 2710: 2702: 2701: 2699: 2698: 2686: 2670: 2656: 2645: 2632: 2630: 2616: 2615: 2613: 2612: 2606: 2604: 2598: 2597: 2579: 2577: 2576: 2569: 2562: 2554: 2546: 2545: 2522: 2491: 2469: 2447: 2424: 2392: 2374: 2338: 2308: 2274: 2246: 2216: 2190: 2169:"Symtuza EPAR" 2160: 2126: 2096: 2066: 2033: 1999: 1969: 1939: 1903: 1869: 1841: 1817:"Odefsey EPAR" 1808: 1774: 1744: 1711: 1681: 1645: 1611: 1583: 1559:"Genvoya EPAR" 1550: 1514: 1480: 1450: 1420: 1386: 1354: 1331: 1304: 1261: 1218: 1194:"Vemlidy EPAR" 1185: 1150: 1120: 1092: 1060: 1049:. 21 June 2022 1034: 1003: 1002: 1000: 997: 965: 962: 961: 960: 957: 954: 951: 945: 934: 927: 916: 913: 821: 820: 818: 817: 814: 812: 809: 801: 800: 799: 796: 795: 793: 792: 789: 781: 780: 779: 776: 775: 773: 772: 764: 762: 754: 753: 747: 741: 740: 734: 728: 722: 716: 711: 705: 704: 700: 699: 697: 696: 688:DTXSID50958941 683: 681: 668: 667: 665: 664: 656: 654: 648: 647: 645: 644: 636: 634: 628: 627: 625: 624: 616: 614: 608: 607: 605: 604: 596: 594: 588: 587: 585: 584: 576: 574: 568: 567: 565: 564: 556: 554: 548: 547: 545: 544: 536: 534: 523: 522: 520: 519: 511: 509: 503: 502: 500: 499: 492: 484: 483: 482: 479: 478: 474: 473: 470: 464: 463: 460: 451: 450: 447: 441: 440: 433: 432: 430: 429: 426: 417: 405: 392: 381: 367: 365: 359: 358: 354: 353: 351: 350: 287: 285: 279: 278: 273: 271:administration 265: 264: 262: 261: 259: 249: 247: 239: 238: 236: 235: 217: 215: 209: 208: 201: 191: 190: 187: 183: 182: 179: 173: 172: 91: 87: 86: 82: 81: 62: 61: 42: 40: 33: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4291: 4280: 4277: 4275: 4274:Phenol esters 4272: 4270: 4267: 4265: 4262: 4260: 4257: 4255: 4252: 4250: 4247: 4245: 4242: 4241: 4239: 4229: 4224: 4219: 4217: 4207: 4203: 4186: 4184: 4181: 4180: 4178: 4175: 4172: 4169: 4167: 4164: 4163: 4159: 4149: 4146: 4144: 4140: 4137: 4135: 4132: 4131: 4129: 4125: 4119: 4116: 4114: 4111: 4110: 4108: 4106: 4102: 4096: 4095:Brincidofovir 4093: 4091: 4088: 4087: 4085: 4081: 4078: 4074: 4068: 4065: 4063: 4060: 4058: 4055: 4053: 4049: 4045: 4044: 4041: 4038: 4036: 4033: 4031: 4028: 4026: 4023: 4021: 4018: 4016: 4012: 4008: 4007: 4005: 4002: 3998: 3988: 3985: 3983: 3980: 3979: 3977: 3975: 3971: 3965: 3962: 3960: 3956: 3955: 3953: 3951: 3947: 3941: 3938: 3936: 3932: 3929: 3928: 3926: 3924: 3920: 3916: 3906: 3903: 3900: 3896: 3895: 3894:early protein 3891: 3889: 3886: 3884: 3881: 3879: 3876: 3874: 3871: 3870: 3868: 3864: 3854: 3851: 3850: 3848: 3844: 3833: 3829: 3828: 3824: 3823: 3818: 3815: 3813: 3810: 3808: 3805: 3804: 3803: 3802: 3798: 3797: 3793: 3790: 3787: 3783: 3780: 3778: 3774: 3773: 3769: 3768: 3766: 3764: 3760: 3753: 3749: 3748: 3744: 3743: 3739: 3735: 3732: 3730: 3726: 3723: 3721: 3717: 3713: 3712: 3708: 3707: 3705: 3703: 3699: 3696: 3693: 3689: 3686: 3682:DNA-synthesis 3680: 3677: 3675: 3671: 3668: 3666: 3662: 3657: 3653: 3649: 3645: 3642: 3635: 3630: 3628: 3623: 3621: 3616: 3615: 3612: 3600: 3597: 3594: 3584: 3582: 3579: 3578: 3576: 3573: 3570: 3567: 3565: 3562: 3561: 3557: 3547: 3544: 3542: 3539: 3537: 3534: 3532: 3529: 3527: 3524: 3522: 3519: 3517: 3514: 3512: 3509: 3507: 3504: 3502: 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3478: 3476: 3474:Failed agents 3472: 3466: 3463: 3461: 3458: 3456: 3453: 3451: 3448: 3446: 3443: 3441: 3438: 3436: 3433: 3431: 3428: 3426: 3423: 3421: 3418: 3416: 3413: 3411: 3408: 3406: 3403: 3401: 3398: 3396: 3393: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3372: 3370: 3366: 3360: 3357: 3356: 3354: 3352: 3348: 3342: 3341:Trichosanthin 3339: 3338: 3336: 3334: 3330: 3324: 3321: 3320: 3318: 3316: 3312: 3305: 3302: 3301: 3299: 3297: 3293: 3290: 3286: 3280: 3279:Ritonavir (r) 3277: 3275: 3272: 3271: 3269: 3265: 3259: 3256: 3254: 3251: 3249: 3246: 3244: 3241: 3239: 3236: 3234: 3231: 3229: 3226: 3224: 3221: 3219: 3216: 3214: 3211: 3209: 3206: 3204: 3201: 3199: 3196: 3194: 3191: 3189: 3186: 3184: 3181: 3178: 3175: 3172: 3169: 3166: 3163: 3161: 3158: 3155: 3152: 3150: 3147: 3145: 3142: 3139: 3136: 3134: 3131: 3129: 3126: 3123: 3120: 3118: 3115: 3114: 3112: 3110: 3106: 3092: 3089: 3087: 3084: 3080: 3077: 3075: 3072: 3070: 3067: 3066: 3065: 3064: 3060: 3059: 3057: 3053: 3047: 3044: 3042: 3039: 3037: 3034: 3033: 3031: 3027: 3024: 3022: 3020: 3014: 3010: 3004: 3001: 2999: 2996: 2994: 2990: 2986: 2985: 2982: 2979: 2977: 2974: 2972: 2969: 2967: 2964: 2962: 2959: 2957: 2954: 2952: 2949: 2947: 2944: 2942: 2939: 2937: 2934: 2932: 2929: 2927: 2924: 2922: 2919: 2917: 2914: 2912: 2908: 2904: 2903: 2901: 2899: 2893: 2890: 2887: 2881: 2871: 2868: 2866: 2863: 2860: 2857: 2854: 2851: 2850: 2848: 2844: 2838: 2835: 2833: 2830: 2828: 2825: 2823: 2820: 2818: 2815: 2813: 2810: 2808: 2805: 2804: 2802: 2798: 2795: 2793: 2791: 2785: 2781: 2775: 2772: 2770: 2767: 2765: 2762: 2761: 2759: 2757: 2753: 2747: 2744: 2742: 2739: 2737: 2734: 2732: 2729: 2727: 2724: 2722: 2719: 2717: 2714: 2713: 2711: 2707: 2703: 2696: 2692: 2691: 2687: 2684: 2680: 2676: 2675: 2671: 2668: 2664: 2660: 2657: 2655: 2651: 2650: 2646: 2643: 2639: 2638: 2634: 2633: 2631: 2629: 2627: 2621: 2617: 2611: 2608: 2607: 2605: 2603: 2599: 2594: 2590: 2587:used against 2586: 2582: 2575: 2570: 2568: 2563: 2561: 2556: 2555: 2552: 2541: 2537: 2533: 2526: 2523: 2510: 2506: 2502: 2495: 2492: 2487: 2483: 2479: 2473: 2470: 2465: 2461: 2457: 2451: 2448: 2443: 2439: 2435: 2428: 2425: 2412: 2408: 2407: 2402: 2396: 2393: 2388: 2384: 2378: 2375: 2359: 2355: 2348: 2342: 2339: 2326: 2322: 2318: 2312: 2309: 2296: 2292: 2290: 2284: 2278: 2275: 2262: 2261: 2260:Health Canada 2256: 2250: 2247: 2234: 2230: 2226: 2220: 2217: 2204: 2200: 2194: 2191: 2178: 2174: 2170: 2164: 2161: 2148: 2144: 2142: 2136: 2130: 2127: 2114: 2110: 2106: 2100: 2097: 2084: 2080: 2076: 2070: 2067: 2054: 2050: 2049: 2044: 2037: 2034: 2021: 2017: 2015: 2009: 2003: 2000: 1987: 1983: 1979: 1973: 1970: 1957: 1953: 1949: 1943: 1940: 1924: 1920: 1913: 1907: 1904: 1891: 1887: 1885: 1879: 1873: 1870: 1857: 1856: 1855:Health Canada 1851: 1845: 1842: 1829: 1825: 1823: 1818: 1812: 1809: 1796: 1792: 1790: 1784: 1778: 1775: 1762: 1758: 1754: 1748: 1745: 1732: 1728: 1726: 1721: 1715: 1712: 1699: 1695: 1691: 1685: 1682: 1666: 1662: 1655: 1649: 1646: 1633: 1629: 1627: 1621: 1615: 1612: 1599: 1598: 1597:Health Canada 1593: 1587: 1584: 1571: 1567: 1565: 1560: 1554: 1551: 1535: 1531: 1524: 1518: 1515: 1502: 1498: 1496: 1490: 1484: 1481: 1468: 1464: 1460: 1454: 1451: 1438: 1434: 1433:Fierce Pharma 1430: 1424: 1421: 1408: 1404: 1402: 1396: 1390: 1387: 1374: 1370: 1369: 1364: 1358: 1355: 1350: 1346: 1340: 1338: 1336: 1332: 1324: 1317: 1316: 1308: 1305: 1300: 1296: 1292: 1288: 1284: 1280: 1276: 1272: 1265: 1262: 1257: 1253: 1249: 1245: 1241: 1237: 1233: 1229: 1222: 1219: 1206: 1202: 1200: 1195: 1189: 1186: 1173: 1169: 1165: 1159: 1157: 1155: 1151: 1138: 1134: 1130: 1124: 1121: 1108: 1107: 1106:Health Canada 1102: 1096: 1093: 1077: 1070: 1064: 1061: 1048: 1044: 1038: 1035: 1022: 1018: 1014: 1008: 1005: 998: 996: 994: 990: 987: 983: 979: 978:emtricitabine 975: 971: 963: 958: 955: 952: 949: 946: 943: 939: 935: 933:; (Complera)) 932: 928: 926:; (Stribild)) 925: 921: 920: 919: 914: 912: 910: 906: 902: 898: 894: 890: 887:based on the 886: 882: 878: 874: 869: 867: 863: 859: 855: 851: 847: 843: 839: 832: 827: 813: 808: 804: 797: 788: 784: 777: 770: 766: 765: 763: 760: 755: 748: 746: 742: 712: 710: 706: 701: 693: 689: 685: 684: 682: 673: 669: 662: 661:ChEMBL2107825 658: 657: 655: 653: 649: 642: 638: 637: 635: 633: 629: 622: 618: 617: 615: 613: 609: 602: 598: 597: 595: 593: 589: 582: 578: 577: 575: 573: 569: 562: 558: 557: 555: 553: 549: 542: 538: 537: 535: 528: 524: 517: 513: 512: 510: 508: 504: 496: 491: 487: 480: 475: 471: 469: 465: 461: 459: 452: 448: 446: 442: 438: 434: 427: 425: Rx-only 418: 416: 406: 403: 393: 391: 382: 379: 369: 368: 366: 364: 360: 355: 347: 342: 337: 332: 327: 322: 317: 312: 307: 302: 297: 292: 289: 288: 286: 284: 280: 277: 274: 272: 266: 260: 251: 250: 248: 246: 240: 233: 228: 219: 218: 216: 214: 210: 206: 202: 200: 196: 192: 188: 184: 180: 178: 174: 168: 92: 90:Pronunciation 88: 85:Clinical data 83: 79: 74: 66: 58: 46: 41: 32: 31: 19: 4134:Filociclovir 4066: 4046: 4009: 3957: 3905:Tromantadine 3892: 3825: 3799: 3782:Trifluridine 3770: 3745: 3720:Valaciclovir 3709: 3595: 3395:Cyanovirin-N 3385:Calanolide A 3061: 3055:2 generation 3029:1 generation 3016: 3002: 2987: 2966:Elvucitabine 2956:Apricitabine 2905: 2846:2 generation 2800:1 generation 2787: 2774:Fipravirimat 2688: 2683:Semzuvolimab 2672: 2663:Cenicriviroc 2647: 2635: 2623: 2540:the original 2535: 2525: 2513:. 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Index

Dolutegravir/emtricitabine/tenofovir alafenamide

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WHO
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