439:
40:
694:
Potential avenues for the development of resistance to doripenem are: altered PBPs (penicillin-binding protein), reduced activity in the permeability of the outer membrane especially when accepting foreign toxic substances within the cell, and deactivation of the drug by hydrolyzing enzymes from the
670:
Doripenem appears as crystalline powder, with colour anywhere from a white to somewhat yellowish. Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also soluble in N,N-dimethylformamide. Doripenem's chemical configuration has 6
729:
In young and healthy adults, the elimination half-life of doripenem considering the average plasma terminal is normally around 1 hour. The plasma clearance is about 15.9 L/hour and the average renal clearance is 10.3 L/hour. Research indicates doripenem is filtered by the glomerular capillary bed
629:
The greater stability of doripenem in aqueous solution compared to earlier members of the carbapenem class allows it to be administered as an infusion over 4 hours or more, which may be advantageous in the treatment of certain difficult-to-treat infections. It may present a lower risk of inducing
712:
On average, about 8.1% of plasma proteins attached to doripenem; it is separate from drug concentrations of plasma. Doripenem’s distribution volume is close to that of extracellular fluid volume in humans (18.2 L). When doripenem is essentially stable, the average volume of distribution is
680:
Seizure risk: carbapenems in general have been reported to cause seizure activity in some people. In addition, those who already have a seizure disorder may be at risk for further seizures if they are using valproic acid to control their seizures; doripenem has been found to decrease serum
671:
asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powdered drug can form a monohydrate when mixed with water. However, doripenem has not been proven to possess polymorphism
518:
684:
Infection related: use of doripenem can lead to clostridium difficile infection. It has also been noted to increase mortality in people who have ventilator-associated bacterial pneumonia, and is no longer recommended as a treatment for this
713:
approximately 16.8 L. Within the few of the body’s fluids and tissues, Doripenem is filtered successfully as well as reaching concentration levels that are able to restrain from more vulnerable bacteria than what is required.
621:
Doripenem can be used for bacterial infections such as: complex abdominal infections, pneumonia within the setting of a hospital, and complicated infections of the urinary tract including kidney infections with
1066:
130:
995:
Nishino Y, Kobayashi M, Shinno T, Izumi K, Yonezawa H, Masui Y, Takahira M (November 2003). "Practical large-scale synthesis of doripenem: A novel 1β-methylcarbapenem antibiotic".
560:
InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
2080:
177:
646:
bacteria. In vivo, doripenem inhibits the synthesis of cell walls by attaching itself to penicillin-binding proteins, also known as PBPs. However it is not active against
576:
2364:
1059:
62:
532:
1052:
113:
2305:
638:
Doripenem is a beta-lactam antibiotic agent belonging to the carbapenem group, with a broad spectrum of bacterial sensitivity including both
1016:
699:
and gram-negative bacteria can stabilize doripenem to hydrolysis. However, carbapenem-hydrolyzing beta-lactamases are an exception.
552:
126:
2349:
1227:
1167:
1156:
260:
207:
94:
2224:
2110:
1276:
969:
867:
Zhanel GG, Ketter N, Rubinstein E, Friedland I, Redman R (2009). "Overview of seizure-inducing potential of doripenem".
751:
358:
2322:
2135:
2055:
1182:
1116:
418:
1044:
1031:
Hagerman JK, Knechtel SA, Kiepser ME (December 2007). "Doripenem: A new extended-spectrum carbapenem antibiotic".
2060:
1187:
108:
1083:
1989:
913:
948:
775:
Mazzei T (August 2010). "The pharmacokinetics and pharmacodynamics of the carbapanemes: focus on doripenem".
2310:
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2214:
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920:
747:
2359:
2105:
2075:
1924:
1886:
721:
Doripenem is metabolized by the enzyme dehydropeptidase-I into an inactive ring-opened metabolite.
434:
293:
170:
739:
892:
800:
141:
1640:
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1004:
876:
839:
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455:
302:
232:
367:
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2016:
1460:
1287:
651:
284:)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclohept-2-ene-2-carboxylic acid
240:
966:"FDA Approves New Drug to Treat Complicated Urinary Tract and Intra-Abdominal Infections"
965:
438:
2316:
1246:
844:
819:
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72:
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1520:
1398:
1355:
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1262:
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1207:
1197:
1075:
80:
654:
including those with extended spectrum, but it is susceptible to the action of
2279:
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2242:
2218:
2189:
2167:
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2006:
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1937:
1868:
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1455:
1336:
1257:
1252:
1079:
66:
888:
853:
796:
949:"Highlights of Prescribing Information: DORIBAX (doripenem for injection)"
31:
2262:
1853:
1829:
1815:
1790:
1745:
1718:
1679:
1625:
1480:
1469:
2166:
Insert into bacterial cell wall causing perforation and depolarization:
313:
17:
1008:
39:
2012:
1508:
623:
398:
245:
914:"Doripenem for Injection for the Treatment of Nosocomial Pneumonia"
387:
1997:
1446:
1146:
517:
508:
647:
378:
103:
1048:
730:
in Bowman’s capsule and the tubular secretions in the nephron.
695:
carbapenem. Beta-lactamases (such as penicillinases) formed by
216:
120:
112:
820:"Doripenem (Doribax): the newest addition to the carbapenems"
423:
758:. It has since been discontinued in the United States.
583:
2081:
Benzathine benzylpenicillin/procaine benzylpenicillin
943:
941:
939:
937:
754:
on
October 12, 2007, to be sold under the tradename
2252:
2202:
2181:
2157:
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1988:
1955:
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93:
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61:
51:
46:
540:O=S(=O)(N)NC3NC(S\C2=C(\N1C(=O)((O)C)12C)C(=O)O)C3
326:
746:in 2005 and is being marketed outside Japan by
301:
750:. Doripenem was approved by the United States
125:
1060:
8:
30:
2154:
1525:
1283:
1163:
1152:
1138:
1067:
1053:
1045:
997:Organic Process Research & Development
437:
346:
280:)-6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-(((5
38:
2188:Inhibits PG elongation and crosslinking:
843:
366:
2365:Drugs developed by Johnson & Johnson
658:. Doripenem is also more active against
767:
557:
537:
433:
265:
85:
29:
406:
71:
7:
1017:"CHMP Assessment Report for Doribax"
954:. U.S. Food and Drug Administration.
908:
906:
189:
386:
317:
25:
2213:subunit synthesis and transport:
630:seizures than other carbapenems.
881:10.2165/00002018-200932090-00001
681:concentrations of valproic acid.
472:
466:
604:) is an antibiotic drug in the
565:Key:AVAACINZEOAHHE-VFZPANTDSA-N
2111:Imipenem/cilastatin/relebactam
836:10.1080/08998280.2008.11928422
484:
478:
460:
1:
612:antibiotic drug able to kill
970:Food and Drug Administration
752:Food and Drug Administration
2136:Ticarcillin/clavulanic acid
2056:Amoxicillin/clavulanic acid
1193:Phenoxymethylpenicillin (V)
1183:Benzathine benzylpenicillin
2381:
666:Physicochemical properties
634:Chemistry and pharmacology
450:Chemical and physical data
2300:
2061:Ampicillin/flucloxacillin
1188:Procaine benzylpenicillin
1024:European Medicines Agency
789:10.1179/joc.2010.22.4.219
573:
548:
528:
256:
37:
734:Regulatory and marketing
662:than other carbapenems.
2126:Piperacillin/tazobactam
2086:Cefepime/enmetazobactam
777:Journal of Chemotherapy
650:. It is stable against
2350:Carbapenem antibiotics
2217:synthesis inhibition (
2101:Ceftolozane/tazobactam
2091:Cefoperazone/sulbactam
1990:β-lactamase inhibitors
968:(Press release). U.S.
818:Greer ND (July 2008).
660:Pseudomonas aeruginosa
615:Pseudomonas aeruginosa
2131:Sulbactam/durlobactam
2116:Meropenem/vaborbactam
2096:Ceftazidime/avibactam
1228:β-lactamase resistant
1168:β-lactamase sensitive
921:Johnson & Johnson
748:Johnson & Johnson
2121:Panipenem/betamipron
2066:Ampicillin/sulbactam
1178:Benzylpenicillin (G)
1112:cell wall by binding
2106:Imipenem/cilastatin
2076:Aztreonam/avibactam
1887:Ceftaroline fosamil
742:of Japan under the
738:It was launched by
34:
2327:Never to phase III
2259:Hydrolyze NAM-NAG
1347:Carboxypenicillins
1110:layer of bacterial
1106:(inhibit synthesis
972:. October 17, 2007
2337:
2336:
2198:
2197:
2144:
2143:
1951:
1950:
1733:Antipseudomonal (
1641:Cefuroxime axetil
1437:
1436:
1433:
1432:
1380:Ureidopenicillins
1271:
1270:
1135:
1128:
1124:
1114:to and inhibiting
1009:10.1021/op034088n
919:(Press release).
591:
590:
519:Interactive image
419:CompTox Dashboard
220:
123:
106:
16:(Redirected from
2372:
2155:
1526:
1382:(4th generation)
1349:(4th generation)
1290:(3rd generation)
1288:Aminopenicillins
1284:
1231:(2nd generation)
1171:(1st generation)
1164:
1153:
1139:
1134:
1126:
1122:
1108:of peptidoglycan
1104:
1069:
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1055:
1046:
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1021:
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981:
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918:
910:
901:
900:
864:
858:
857:
847:
815:
809:
808:
772:
703:Pharmacokinetics
608:class. It is a
587:
586:
579:
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501:
486:
480:
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305:
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133:
122:
119:
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105:
102:
89:
75:
57:Finibax, Doribax
42:
35:
33:
21:
2380:
2379:
2375:
2374:
2373:
2371:
2370:
2369:
2340:
2339:
2338:
2333:
2332:
2317:Clinical trials
2296:
2248:
2194:
2177:
2140:
2044:
2017:Clavulanic acid
1984:
1947:
1919:
1901:
1873:
1840:
1705:
1612:
1519:
1515:
1511:
1503:
1461:Antipseudomonal
1429:
1403:
1374:
1341:
1278:
1267:
1230:
1222:
1170:
1158:
1131:transpeptidases
1130:
1120:
1115:
1113:
1111:
1109:
1107:
1105:
1103:
1095:
1073:
1043:
1030:
1019:
1015:
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988:Further reading
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923:. July 16, 2008
916:
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911:
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773:
769:
764:
736:
727:
719:
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675:Adverse effects
668:
652:beta-lactamases
636:
582:
580:
577:(what is this?)
574:
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566:
561:
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544:
541:
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233:Pharmacokinetic
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136:
28:
23:
22:
15:
12:
11:
5:
2378:
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2200:
2199:
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2185:
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2152:
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2138:
2133:
2128:
2123:
2118:
2113:
2108:
2103:
2098:
2093:
2088:
2083:
2078:
2073:
2063:
2058:
2052:
2050:
2046:
2045:
2043:
2042:
2036:
2031:
2026:
2022:non-β-lactam (
2020:
2010:
2004:
1994:
1992:
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1911:
1909:
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1900:
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1889:
1883:
1881:
1879:5th generation
1875:
1874:
1872:
1871:
1866:
1861:
1856:
1850:
1848:
1846:4th generation
1842:
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1823:
1818:
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1711:3rd generation
1707:
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1677:
1672:
1663:
1658:
1653:
1648:
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1628:
1622:
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1618:2nd generation
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1600:
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1575:
1570:
1565:
1560:
1555:
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1532:
1530:1st generation
1523:
1513:Cephalosporins
1505:
1504:
1502:
1501:
1495:
1489:
1483:
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1472:
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1281:
1273:
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1247:Flucloxacillin
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1234:
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1215:
1210:
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1195:
1190:
1185:
1180:
1174:
1172:
1161:
1150:
1136:
1097:
1096:
1078:active on the
1076:Antibacterials
1074:
1072:
1071:
1064:
1057:
1049:
1042:
1041:
1039:(12): 676–688.
1028:
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989:
986:
983:
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933:
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859:
810:
766:
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664:
656:carbapenemases
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14:
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10:
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2:
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2255:
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2240:
2237:
2234:
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2226:
2223:
2220:
2216:
2212:
2208:
2207:
2205:
2203:Intracellular
2201:
2191:
2187:
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2180:
2174:
2171:
2169:
2165:
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2160:
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2151:
2147:
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2129:
2127:
2124:
2122:
2119:
2117:
2114:
2112:
2109:
2107:
2104:
2102:
2099:
2097:
2094:
2092:
2089:
2087:
2084:
2082:
2079:
2077:
2074:
2071:
2070:Sultamicillin
2067:
2064:
2062:
2059:
2057:
2054:
2053:
2051:
2047:
2040:
2037:
2035:
2032:
2030:
2027:
2025:
2021:
2018:
2014:
2011:
2008:
2005:
2003:
1999:
1996:
1995:
1993:
1991:
1987:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1962:
1960:
1958:
1954:
1944:
1941:
1939:
1936:
1934:
1931:
1930:
1928:
1926:
1922:
1916:
1913:
1912:
1910:
1908:
1904:
1898:
1895:
1893:
1890:
1888:
1885:
1884:
1882:
1880:
1876:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1851:
1849:
1847:
1843:
1836:
1833:
1831:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1741:
1738:
1736:
1732:
1730:
1727:
1725:
1722:
1720:
1717:
1716:
1714:
1712:
1708:
1701:
1697:
1694:
1691:
1688:
1686:
1685:Cefbuperazone
1683:
1681:
1678:
1676:
1673:
1671:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1623:
1621:
1619:
1615:
1609:
1606:
1604:
1601:
1599:
1596:
1594:
1591:
1589:
1586:
1584:
1581:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1535:
1533:
1531:
1527:
1524:
1522:
1518:
1514:
1510:
1506:
1499:
1496:
1494:
1490:
1487:
1484:
1482:
1479:
1476:
1473:
1471:
1468:
1466:
1462:
1459:
1457:
1454:Carbapenems (
1453:
1452:
1450:
1448:
1444:
1440:
1426:
1425:Sulbenicillin
1423:
1420:
1419:Pivmecillinam
1416:
1413:
1412:
1410:
1406:
1400:
1397:
1395:
1392:
1390:
1387:
1386:
1384:
1381:
1377:
1371:
1368:
1366:
1365:Carindacillin
1362:
1361:Carbenicillin
1359:
1357:
1354:
1353:
1351:
1348:
1344:
1338:
1335:
1332:
1331:Talampicillin
1329:
1327:
1326:Metampicillin
1324:
1322:
1321:Lenampicillin
1319:
1317:
1316:Bacampicillin
1314:
1312:
1309:
1307:
1306:Pivampicillin
1303:
1300:
1298:
1295:
1294:
1292:
1289:
1285:
1282:
1280:
1274:
1264:
1261:
1259:
1256:
1254:
1251:
1248:
1245:
1243:
1242:Dicloxacillin
1239:
1236:
1235:
1233:
1229:
1225:
1219:
1216:
1214:
1213:Clometocillin
1211:
1209:
1206:
1204:
1203:Pheneticillin
1201:
1199:
1196:
1194:
1191:
1189:
1186:
1184:
1181:
1179:
1176:
1175:
1173:
1169:
1165:
1162:
1160:
1154:
1151:
1148:
1144:
1140:
1137:
1132:
1118:
1102:
1098:
1093:
1089:
1085:
1081:
1077:
1070:
1065:
1063:
1058:
1056:
1051:
1050:
1047:
1038:
1034:
1029:
1025:
1018:
1014:
1010:
1006:
1003:(6): 846–50.
1002:
998:
993:
992:
987:
971:
967:
961:
958:
950:
944:
942:
940:
938:
934:
922:
915:
909:
907:
903:
898:
894:
890:
886:
882:
878:
875:(9): 709–16.
874:
870:
863:
860:
855:
851:
846:
841:
837:
833:
830:(3): 337–41.
829:
825:
821:
814:
811:
806:
802:
798:
794:
790:
786:
783:(4): 219–25.
782:
778:
771:
768:
761:
759:
757:
753:
749:
745:
741:
733:
731:
724:
722:
716:
714:
707:
702:
700:
698:
697:gram-positive
689:
683:
679:
678:
674:
672:
665:
663:
661:
657:
653:
649:
645:
644:gram-negative
641:
640:gram-positive
633:
631:
627:
625:
619:
617:
616:
611:
607:
603:
599:
595:
585:
578:
572:
563:
558:
554:
547:
538:
534:
527:
520:
516:
515:
513:
510:
505:
498:
496:
492:
459:
457:
453:
448:
440:
436:
435:DTXSID2046678
432:
431:
429:
420:
416:
409:
405:
404:
402:
400:
396:
389:
385:
384:
382:
380:
376:
369:
365:
364:
362:
360:
356:
349:
345:
344:
342:
340:
336:
329:
325:
324:
322:
315:
311:
304:
300:
299:
297:
295:
291:
283:
279:
275:
271:
266:
262:
255:
250:
247:
244:
242:
238:
234:
230:
224:
214:
213:
211:
209:
205:
200:
192:
187:
184:
183:
181:
179:
175:
172:
168:
165:
163:
157:
150:
149:
147:
145:
139:
132:
128:
118:
115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
19:
2355:Pyrrolidines
2241:inhibitors (
2231:inhibitors (
2159:Lipopeptides
2150:Polypeptides
2049:Combinations
1980:Nocardicin A
1897:Ceftobiprole
1740:Cefoperazone
1598:Cefaloridine
1583:Cefaloglycin
1521:Carbacephems
1464:
1389:Piperacillin
1218:Penamecillin
1119:, a group of
1036:
1032:
1023:
1000:
996:
974:. Retrieved
960:
925:. Retrieved
872:
868:
862:
827:
823:
813:
780:
776:
770:
755:
740:Shionogi Co.
737:
728:
720:
711:
708:Distribution
693:
669:
637:
628:
620:
613:
601:
597:
593:
592:
581:
575:
408:ChEMBL491571
281:
277:
273:
269:
208:Legal status
202:Legal status
95:License data
2313:from market
2292:Teixobactin
2270:Tyrothricin
2239:bactoprenol
2233:Cycloserine
2039:Vaborbactam
2029:Durlobactam
1957:Monobactams
1915:Cefiderocol
1907:Siderophore
1892:Ceftolozane
1806:Cefpimizole
1776:Cefpodoxime
1771:Cefpiramide
1766:Cefmenoxime
1761:Ceftizoxime
1756:Cefdaloxime
1735:Ceftazidime
1724:Ceftriaxone
1696:Carbacephem
1690:Cefmetazole
1646:Cefamandole
1608:Cefatrizine
1588:Cefacetrile
1573:Cefroxadine
1517:Cephamycins
1443:Carbapenems
1399:Mezlocillin
1356:Ticarcillin
1297:Amoxicillin
1263:Methicillin
1238:Cloxacillin
1208:Azidocillin
1198:Propicillin
1143:Penicillins
869:Drug Safety
824:Proceedings
610:beta-lactam
502: g·mol
303:148016-81-3
252:Identifiers
81:MedlinePlus
53:Trade names
2360:Sulfamides
2344:Categories
2280:Tyrocidine
2275:Gramicidin
2243:Bacitracin
2219:Fosfomycin
2190:Ramoplanin
2168:Daptomycin
2034:Relebactam
2007:Tazobactam
1938:Cefquinome
1925:Veterinary
1869:Cefquinome
1859:Cefozopran
1821:Ceftiolene
1811:Cefsulodin
1801:Cefodizime
1786:Cefditoren
1781:Ceftibuten
1729:Cefotaxime
1700:Loracarbef
1666:Cephamycin
1656:Ceforanide
1636:Cefuroxime
1593:Cefalonium
1563:Cefazaflur
1558:Cefazedone
1548:Cefadroxil
1415:Mecillinam
1394:Azlocillin
1370:Temocillin
1311:Hetacillin
1302:Ampicillin
976:2007-10-25
927:2010-05-19
762:References
744:brand name
717:Metabolism
690:Resistance
685:condition.
606:carbapenem
507:3D model (
495:Molar mass
368:BHV525JOBH
339:ChemSpider
294:CAS Number
261:IUPAC name
241:Metabolism
27:Antibiotic
2323:Phase III
2311:Withdrawn
2287:Isoniazid
2173:Surfactin
2024:Avibactam
2002:Sulbactam
1975:Carumonam
1970:Tigemonam
1965:Aztreonam
1943:Cefovecin
1933:Ceftiofur
1864:Cefpirome
1835:Latamoxef
1826:Oxacephem
1796:Cefetamet
1751:Cefcapene
1675:Cefotetan
1670:Cefoxitin
1661:Cefuzonam
1651:Cefonicid
1631:Cefprozil
1603:Cefalotin
1578:Ceftezole
1568:Cefradine
1553:Cefapirin
1543:Cefalexin
1538:Cefazolin
1498:Ritipenem
1493:Faropenem
1486:Panipenem
1475:Meropenem
1465:Doripenem
1456:Ertapenem
1337:Epicillin
1258:Nafcillin
1253:Oxacillin
1101:β-lactams
1080:cell wall
1033:Formulary
725:Excretion
594:Doripenem
160:Routes of
142:Pregnancy
131:Doripenem
73:Monograph
67:Drugs.com
32:Doripenem
2263:lysozyme
2209:Inhibit
1854:Cefepime
1830:Flomoxef
1816:Cefteram
1791:Cefotiam
1746:Cefdinir
1719:Cefixime
1680:Cefminox
1626:Cefaclor
1491:Penems (
1481:Biapenem
1470:Imipenem
1279:spectrum
1277:Extended
1159:spectrum
1129:-alanine
1125:-alanyl-
1084:envelope
897:25385572
889:19670912
854:18628935
805:72019292
797:20685624
584:(verify)
178:ATC code
144:category
1509:Cephems
1026:. 2008.
845:2446428
756:Doribax
602:Finibax
598:Doribax
456:Formula
314:PubChem
194:)
188: (
186:J01DH04
129::
111::
87:a608015
18:Doribax
2306:WHO-EM
2013:Clavam
1447:Penems
1157:Narrow
1147:Penams
895:
887:
852:
842:
803:
795:
624:sepsis
533:SMILES
500:420.50
399:ChEMBL
388:D03895
223:℞-only
221:
124:
114:by INN
107:
2253:Other
2225:DADAL
2182:Other
1998:Penam
1408:Other
1020:(PDF)
952:(PDF)
917:(PDF)
893:S2CID
801:S2CID
553:InChI
509:JSmol
348:66040
328:73303
246:Renal
1117:PBPs
1092:J01D
1088:J01C
1082:and
885:PMID
850:PMID
793:PMID
648:MRSA
642:and
379:KEGG
359:UNII
235:data
63:AHFS
2215:NAM
1005:doi
877:doi
840:PMC
832:doi
785:doi
424:EPA
318:CID
191:WHO
127:FDA
109:EMA
2346::
2319::
2229:AR
2211:PG
1445:/
1363:/
1037:42
1035:.
1022:.
999:.
936:^
905:^
891:.
883:.
873:32
871:.
848:.
838:.
828:21
826:.
822:.
799:.
791:.
781:22
779:.
626:.
618:.
600:,
470:24
464:15
276:,6
272:,5
268:(4
217:US
171:IV
169:,
167:IM
121:US
104:EU
2245:)
2235:)
2227:/
2221:)
2072:)
2068:(
2041:)
2019:)
2015:(
2009:)
2000:(
1837:)
1828:(
1742:)
1702:)
1698:(
1692:)
1668:(
1500:)
1488:)
1477:)
1463:(
1421:)
1417:(
1333:)
1304:(
1249:)
1240:(
1149:)
1145:(
1133:)
1127:D
1123:D
1094:)
1090:-
1086:(
1068:e
1061:t
1054:v
1011:.
1007::
1001:7
979:.
930:.
899:.
879::
856:.
834::
807:.
787::
596:(
511:)
488:2
485:S
482:6
479:O
476:4
473:N
467:H
461:C
426:)
422:(
282:S
278:S
274:S
270:R
219::
151:B
65:/
20:)
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