1912:
1547:
706:
307:
48:
1354:
1142:
526:. He is involved in the study of membrane transporters, and their necessary involvement in the transmembrane uptake of pharmaceutical drugs. He tends to choose scientific problems in which the prevailing orthodoxy is clearly incorrect. To this end, he has recently returned to the study of bioenergetics, summarising the detailed evidence against the prevailing wisdom of
486:. He has also been involved in the development of multivariate scientific instrumentation and the attendant machine learning software (his first paper on artificial neural networks was in 1992). He has written extensively on the role of microbes as agents of supposedly 'non-communicable', chronic infectious diseases. His publications are mostly
1158:; Teusink, L. M.; Broadhurst, B.; Zhang, D.; Hayes, N.; Walsh, A.; Berden, M. C.; Brindle, J. A.; Kell, K. M.; Rowland, D. B.; Westerhoff, J. J.; Van Dam, H. V.; Oliver, K. (2001). "A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations".
1427:
Dobson, P. D.; Smallbone, K.; Jameson, D.; Simeonidis, E.; Lanthaler, K.; Pir, P.; Lu, C.; Swainston, N.; Dunn, W. B.; Fisher, P.; Hull, D.; Brown, M.; Oshota, O.; Stanford, N. J.; Kell, D. B.; King, R. D.; Oliver, S. G.; Stevens, R. D.; Mendes, P. (2010).
588:, Wales). In 2019 he was a co-founding director of Mellizyme Ltd, now Epoch Biodesign; he left the company in 2023. He cofounded PhenUTest Ltd in 2021. He is an Associated Scientific Director of the Centre for Biosustainability at the
2006:
1717:
Kell, Douglas B.; Pretorius, Etheresia (2017). "Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting".
652:
161:
452:
440:
213:
1991:
1943:
365:
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120:
928:
1971:
1864:
608:
444:
2026:
2001:
1996:
1986:
1578:
2016:
349:
573:, even in supposedly non-infectious diseases. Kell and Pretorius report that such fibrin amyloid microclots (fibrinaloids) seem to be of major significance in
1670:"Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide"
632:
320:
29:
1976:
604:
648:
328:
324:
37:
33:
1611:
Kell, Douglas B. (2021). "A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation".
377:
357:
1064:
932:
987:
1628:
1090:
847:
783:
581:
456:
929:"19 June 2012 - Reappointment of Chief Executive for the Biotechnology and Biological Sciences Research Council - News - BBSRC"
902:
589:
675:
2011:
409:
1582:
57:
1484:
1304:
1240:
1155:
972:
519:
448:
531:
644:
616:
460:
422:
353:
281:
218:
580:
In 1988, he was a founding director of Aber
Instruments, based at Aberystwyth Science Park (originally at the
947:
1939:
968:
831:
734:
612:
464:
361:
345:
208:
1911:
360:(MIB) where he founded and led the Manchester Centre for Integrative Systems Biology (MCISB). He served as
1981:
1353:
1256:
436:
223:
1112:
244:
1003:
636:
483:
468:
187:
1765:"A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications"
1372:"Journal club: A systems biologist ponders how disparate ideas can sometimes come together beautifully"
2021:
1849:
1383:
1318:
1068:
535:
413:
393:
228:
108:
1845:
1261:
499:
1784:
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1409:
1342:
1183:
886:
570:
1878:"We have written a free book (monograph) on why people believe crazy things, including #Brexit "
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47:
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853:
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826:
820:
761:
515:
479:
385:
98:
53:
1307:(2004). "Functional genomic hypothesis generation and experimentation by a robot scientist".
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1205:(2004). "Metabolomics by numbers: Acquiring and understanding global metabolite data".
1041:
1016:
756:
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596:
495:
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1965:
1953:
1731:
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417:
1763:
Kell, Douglas B.; Laubscher, Gert
Jacobus; Pretorius, Etheresia (23 February 2022).
1187:
999:
983:
906:
1413:
1346:
1292:
730:. Magnitude, sites of generation and comparison with the phosphorylation potential"
679:
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527:
511:
503:
405:
401:
1218:
864:
1620:
1141:
1017:"The virtue of innovation: Innovation through the lenses of biological evolution"
585:
487:
569:). They report that such amyloidogenic clotting appears to be mostly caused by
1091:"Prof Stuart Ferguson Page - Department of Biochemistry, University of Oxford"
857:
574:
558:
333:
1901:
Kell DB, Welch GR (2018) Belief: the baggage behind our being. OSF preprints
1796:
1788:
1638:
1126:
1906:
1446:
389:
337:
1814:
1749:
1703:
1685:
1646:
1524:
1465:
1405:
1338:
1247:; Baganz, F. (1998). "Systematic functional analysis of the yeast genome".
1226:
1179:
1050:
1032:
471:, which were the world's first department of biochemistry at a University.
1579:"How Drugs Really Get Into Cells: Why Passive Bilayer Diffusion is a Myth"
1505:
1278:
765:
546:
1780:
1668:
Pretorius E, Mbotwe S, Bester J, Robinson CJ, Kell DB (September 2016).
1330:
506:
and the yeast genome. He has also been involved in research to create a
562:
550:
491:
1740:
1489:"The genetic control of growth rate: A systems biology study in yeast"
1430:"Further developments towards a genome-scale metabolic model of yeast"
747:
344:
in the
Institute of Systems, Molecular and Integrative Biology at the
1562:
640:
554:
381:
238:
1396:
1371:
2007:
Fellows of the
American Association for the Advancement of Science
1171:
1130:
726:"The protonmotive force in phosphorylating membrane vesicles from
600:
653:
Fellow of the
American Association for the Advancement of Science
162:
Fellow of the
American Association for the Advancement of Science
1541:
1295:; Whelan, K. E.; Jones, F. M.; Reiser, P. G. K.; Bryant, C. H.;
1537:
592:, where he runs the Flux Optimisation and Bioanalytics Group.
1201:
Goodacre, R.; Vaidyanathan, S.; Dunn, W. B.; Harrigan, G. G.;
1828:
441:
University of
Manchester Institute of Science and Technology
214:
University of
Manchester Institute of Science and Technology
785:
Computer simulation of the dynamics of biochemical pathways
903:"Prof Douglas Kell, research profile - personal details"
788:(PhD thesis). University of Aberystwyth. Archived from
639:, for services to science and research. Kell is also a
1944:
Biotechnology and
Biological Sciences Research Council
1597:
366:
Biotechnology and
Biological Sciences Research Council
299:
204:
Biotechnology and Biological Sciences Research Council
498:
his most cited peer-reviewed research papers are in
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149:
126:
115:
104:
94:
86:
64:
23:
1865:Engineering and Physical Sciences Research Council
819:
609:Engineering and Physical Sciences Research Council
445:Engineering and Physical Sciences Research Council
494:at Google Scholar in excess of 130. According to
451:(RSC) Research Chair in Bioanalytical Sciences. (
565:, the enzyme responsible for breaking up clots (
392:where he was top scholar. He graduated from the
693:
691:
689:
561:that — unlike regular clots — are resistant to
427:supervised by Stuart Ferguson and Philip John.
416:degree, completed in 1978 with a thesis on the
1992:Commanders of the Order of the British Empire
1114:The bioenergetics of paracoccus denitrificans
245:The Bioenergetics of Paracoccus denitrificans
8:
1846:UK Government Grants awarded to Douglas Kell
633:Commander of the Order of the British Empire
408:, where he was an undergraduate student of
1479:Pir, P.; Gutteridge, A.; Wu, J.; Rash, B.;
1921:
1615:. Vol. 78. Elsevier. pp. 1–177.
1545:
905:. University of Manchester. Archived from
890:(Supplement). 31 December 2013. p. 9.
777:
775:
704:
611:(EPSRC). His former doctoral students and
538:, replacing it with a protet-based model.
305:
46:
20:
1972:Academics of the University of Manchester
1804:
1739:
1693:
1514:
1504:
1455:
1445:
1395:
1260:
1040:
946:Van Noorden, Richard (24 November 2008).
813:
811:
809:
807:
755:
474:Kell's primary research interests are in
2027:Academics of the University of Liverpool
716:
714:
2002:Fellows of the Royal Society of Biology
1997:Fellows of the Learned Society of Wales
1596:Kell, Douglas Bruce (9 February 2020).
670:
668:
664:
595:Kell's research has been funded by the
1121:(DPhil thesis). University of Oxford.
1021:Journal of the Royal Society Interface
649:Fellow of the Royal Society of Biology
553:self-assembly of the clotting protein
876:
874:
358:Manchester Institute of Biotechnology
7:
2017:People educated at Bradfield College
621:Belief: the baggage behind our being
545:, Kell discovered the amyloidogenic
1987:Alumni of St John's College, Oxford
1015:Kell, D. B.; Lurie-Luke, E (2015).
490:and are very widely cited, with an
840:10.1093/ww/9780199540884.013.42346
14:
1065:"Hydneye House - a set on Flickr"
724:; John, P.; Ferguson, S. (1978).
582:Centre for Alternative Technology
522:, as well as several projects in
457:Victoria University of Manchester
332:(born 7 April 1953) is a British
1977:Alumni of Aberystwyth University
1910:
1732:10.1016/j.pbiomolbio.2016.08.006
1613:Advances in Microbial Physiology
1352:
1140:
1581:. 30 April 2020. Archived from
590:Technical University of Denmark
435:From 1978 to 2002 he worked at
139:
1861:Grants awarded to Douglas Kell
782:Mendes, Pedro Pedrosa (1994).
536:photosynthetic phosphorylation
412:. He stayed in Oxford for his
404:in 1975 with a distinction in
1:
1271:10.1016/S0167-7799(98)01214-1
1219:10.1016/j.tibtech.2004.03.007
1876:Kell, Doug (15 March 2018).
1621:10.1016/bs.ampbs.2021.01.001
865:UK public library membership
1559:Douglas Kell's publications
986:author profile page at the
969:Interview with Douglas Kell
821:"Kell, Prof. Douglas Bruce"
368:(BBSRC) from 2008 to 2013.
348:. He was previously at the
2043:
973:Royal Society of Chemistry
830:(176th ed.). Oxford:
449:Royal Society of Chemistry
1950:
1937:
1929:
1924:
1598:"Protet_PCT model of ETP"
948:"Interview: Douglas Kell"
410:St John's College, Oxford
290:
168:
45:
1720:Prog. Biophys. Mol. Biol
1565:bibliographic database.
728:Paracoccus denitrificans
700:publications indexed by
645:Learned Society of Wales
613:postdoctoral researchers
605:Medical Research Council
549:of blood, involving the
461:University of Manchester
423:Paracoccus denitrificans
372:Education and early life
354:University of Manchester
219:University of Manchester
1567:(subscription required)
1447:10.1186/1752-0509-4-145
1249:Trends in Biotechnology
1207:Trends in Biotechnology
832:Oxford University Press
735:The Biochemical Journal
623:was published in 2018.
467:in 2018 to work in the
465:University of Liverpool
459:in 2004, to become the
362:chief executive officer
346:University of Liverpool
209:University of Liverpool
1686:10.1098/rsif.2016.0539
1033:10.1098/rsif.2014.1183
971:on the website of the
901:Kell, Douglas (2012).
541:With his collaborator
510:in collaboration with
443:(UMIST) in 2002 as an
437:Aberystwyth University
224:Aberystwyth University
1907:10.17605/OSF.IO/PNXCS
1506:10.1186/1752-0509-6-4
1004:Europe PubMed Central
676:"AAAS - 2012 Fellows"
637:2014 New Year Honours
528:chemiosmotic coupling
484:computational biology
469:Johnston Laboratories
406:chemical pharmacology
188:Computational biology
1850:Research Councils UK
1544:Bibliography Server
1160:Nature Biotechnology
414:Doctor of Philosophy
394:University of Oxford
380:at Hydneye House in
229:University of Oxford
109:University of Oxford
56:after receiving his
2012:British biochemists
1925:Government offices
1781:10.1042/BCJ20220016
1769:Biochemical Journal
1493:BMC Systems Biology
1434:BMC Systems Biology
1388:2009Natur.460..669K
1331:10.1038/nature02236
1323:2004Natur.427..247K
1109:Kell, Douglas Bruce
631:Kell was appointed
557:into highly stable
500:functional genomics
463:.) He moved to the
431:Research and career
350:School of Chemistry
1833:epochbiodesign.com
1135:uk.bl.ethos.461649
1071:on 23 January 2013
1002:publications from
887:The London Gazette
627:Awards and honours
378:privately educated
317:Douglas Bruce Kell
69:Douglas Bruce Kell
16:British biochemist
1960:
1959:
1951:Succeeded by
1829:"Epoch BioDesign"
1680:(122): 20160539.
1674:J R Soc Interface
1585:on 15 April 2021.
1317:(6971): 247–252.
1027:(103): 20141183.
950:. Chemistry World
863:(Subscription or
748:10.1042/bj1740257
682:on 23 March 2013.
571:infectious agents
516:Stephen Muggleton
480:synthetic biology
386:Bradfield College
313:
312:
275:Doctoral students
170:Scientific career
99:Bradfield College
54:Buckingham Palace
2034:
1948:2008–2013
1933:Julia Goodfellow
1930:Preceded by
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1297:Muggleton, S. H.
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1198:
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1093:. Archived from
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1067:. Archived from
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935:on 26 June 2012.
931:. Archived from
925:
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914:
909:on 14 March 2012
898:
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834:. p. 2736.
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792:on 14 April 2013
779:
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678:. Archived from
672:
619:. His monograph
455:merged with the
439:, moving to the
398:Bachelor of Arts
331:
309:
304:
301:
257:Doctoral advisor
251:
143:
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82:
78:
76:
52:Douglas Kell at
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1882:Twitter @dbkell
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1595:
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1590:
1577:
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1566:
1561:indexed by the
1557:
1553:
1538:Douglas B. Kell
1536:
1532:
1478:
1477:
1473:
1426:
1425:
1421:
1397:10.1038/460669e
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1234:
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1097:on 20 May 2013.
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990:Digital Library
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543:Resia Pretorius
524:systems biology
508:robot scientist
476:systems biology
433:
420:of the microbe
374:
356:, based in the
342:Systems Biology
319:
315:
298:
286:
270:
264:Stuart Ferguson
249:
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183:Systems biology
145:
142: 1989)
137:
133:
132:Dr Antje Wagner
105:Alma mater
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1255:(9): 373–378.
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702:Google Scholar
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607:(MRC) and the
597:European Union
496:Google Scholar
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1982:Living people
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1954:Jackie Hunter
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1485:Oliver, S. G.
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197:Institutions
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79:7 April 1953
25:Douglas Kell
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2022:1953 births
1481:Kell, D. B.
1301:Kell, D. B.
1293:King, R. D.
1203:Kell, D. B.
882:"No. 60728"
586:Machynlleth
488:open access
267:Philip John
111:(BA, DPhil)
87:Nationality
1966:Categories
1741:2263/59001
1241:Oliver, S.
1075:18 January
867:required.)
858:1402257203
659:References
647:(FLSW), a
599:(EU), the
575:long COVID
447:(EPSRC) /
400:degree in
334:biochemist
75:1953-04-07
1797:0264-6021
1789:1470-8728
1655:234894761
1639:0065-2911
1257:CiteSeerX
1127:863351446
827:Who's Who
532:oxidative
512:Ross King
390:Berkshire
376:Kell was
338:Professor
95:Education
1887:19 March
1815:35195253
1750:27554450
1726:: 6–41.
1704:27605168
1647:34147184
1525:22244311
1487:(2012).
1466:21029416
1406:19661875
1370:(2009).
1339:14724639
1245:Kell, D.
1227:15109811
1188:15491882
1180:11135551
1111:(1978).
1051:25505138
722:Kell, D.
655:(FAAS).
615:include
559:β-sheets
547:clotting
300:dbkgroup
150:Children
1942:of the
1863:by the
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1384:Bibcode
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1319:Bibcode
1279:9744112
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913:12 June
796:18 June
757:1185905
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239:Thesis
176:Fields
164:(2012)
158:Awards
127:Spouse
1785:eISSN
1651:S2CID
1499:: 4.
1410:S2CID
1343:S2CID
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1131:EThOS
601:BBSRC
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1123:OCLC
1077:2017
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915:2012
854:OCLC
844:ISBN
798:2012
762:PMID
534:and
518:and
482:and
384:and
336:and
329:FLSW
325:FRSB
302:.org
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38:FLSW
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1940:CEO
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