428:
404:
416:
189:
43:
48:
47:
44:
49:
46:
505:
5–Year relative survival rate: Age 20–44, 76%. Age 45–54, 67%. Age 55–64, 45%. Procarbazine, lomustine and vincristine have been used since May 1975. For 48 years, new therapeutic options have been regularly tested as part of therapy studies to improve the treatment of anaplastic oligodendroglioma.
448:
at the time of diagnosis, a complete surgical removal of all tumor cells is not possible. The "1p / 19q
Codeletion" marker plays an increasingly important role in the selection of therapy and therapy combinations. Because this tumor is an "indolent condition" (a slowly progressive medical condition
527:
treatment (not reached, vs. 7.1 years). A recent long-term study does affirm that radiation combined with adjuvant chemotherapy is significantly more efficacious for anaplastic oligodendroglioma patients with 1p 19q co-deleted tumors and has become the new standard of care. It is possible that
443:
Surgery can help reduce symptoms caused by the tumor. As complete as possible removal of the tumor visible on the MRI is preferred, provided the location of the tumor allows this. Since typically the cells of an anaplastic oligodendroglioma have already migrated into the surrounding healthy
546:
Weller M, van den Bent M, Preusser M, Le Rhun E, Tonn JC, Minniti G, Bendszus M, Balana C, Chinot O, Dirven L, French P, Hegi ME, A. S. Jakola, M. Platten, P. Roth, R. Rudà, S. Short, M. Smits, M. J. Taphoorn, A. von
Deimling, M. Westphal, R. Soffietti, G. Reifenberger, W. Wick:
522:
Annual
Meeting, suggests that PCV therapy may be effective. Median time to progression for patients with 1p19q co-deletion was longer following PCV alone (7.6 years) than with temozolomide alone (3.3 years); median overall survival was also longer with PCV treatment versus
1064:
1049:
45:
532:
will typically remove as much of the tumor as he or she can without damaging other critical, healthy brain structures. Recent studies suggest that radiation does not improve overall survival (even when age, clinical data,
986:
Mohile NA, Forsyth P, Stewart D, et al. (September 2008). "A phase II study of intensified chemotherapy alone as initial treatment for newly diagnosed anaplastic oligodendroglioma: an interim analysis".
403:
1587:
1487:
1205:
1146:
204:
1079:
207:, "anaplastic oligodendroglioma" is not a separate type of tumor. Most are instead classified as the grade 3 subtype of "oligodendroglioma, IDH-mutant and 1p/19q-codeleted".
57:
Video of tumor growth simulation (anaplastic oligodendroglioma). Simulation was run for 2600 days since tumor onset (one original cell) with a detection level of 1 cell/mm2.
929:
427:
1118:
415:
397:
more likely. The designation of grade III oligodendroglioma (high grade) generally subsumes the previous diagnoses of anaplastic or malignant oligodendroglioma.
1450:
894:
Lassman, A. B. (20 May 2009). "Retrospective analysis of outcomes among more than 1,000 patients with newly diagnosed anaplastic oligodendroglial tumors".
777:
742:
Engelhard HH, Stelea A, Mundt A (November 2003). "Oligodendroglioma and anaplastic oligodendroglioma: clinical features, treatment, and prognosis".
377:. Anaplastic oligodendrogliomas often show a loss of genetic material. About 50 to 70% of WHO grade III anaplastic oligodendrogliomas have combined
802:
Ostrom, Quinn T.; Gittleman, Haley; Liao, Peter; Vecchione-Koval, Toni; Wolinsky, Yingli; Kruchko, Carol; Barnholtz-Sloan, Jill S. (October 2017).
1571:
1495:
1419:
519:
943:
Sunyach MP, Jouvet A, Perol D, et al. (December 2007). "Role of exclusive chemotherapy as first line treatment in oligodendroglioma".
603:
528:
radiotherapy may prolong the overall time to progression for non-deleted tumors. If the tumor mass compresses adjacent brain structures, a
389:
19 (19q). This change is mostly referred to as "1p / 19q Co
Deletion". It can be seen as favorable for the patient and makes a response to
497:(PCV) has been shown to be effective and was the most commonly used chemotherapy regimen used for treating anaplastic oligodendrogliomas.
728:
1257:
1111:
871:
854:
1445:
264:
oligodendroglioma, grade IV. The vast majority of oligodendrogliomas occur sporadically, without a confirmed cause and without
249:
804:"CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014"
1104:
855:"Phase II study of procarbazine, CCNU, and vincristine combination chemotherapy in the treatment of malignant brain tumors"
1252:
1424:
198:
370:
713:
358:
1509:
691:
1632:
1348:
1343:
1135:
518:
grade III. A retrospective study on 1054 patients with anaplastic oligodendroglioma, presented during the 2009
1127:
636:
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (August 2007).
345:. This tumor occurs primarily in middle adulthood with a frequency peak in the 4th and 5th decade of life.
1599:
Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see
1267:
1262:
1196:
323:
128:
1564:
1523:
1247:
1622:
1528:
1338:
1058:
930:"New Standard of Care for Anaplastic Oligodendroglial Tumors with 1p/19q Codeletions – the ASCO Post"
230:
1371:
409:
Histopathological image of anaplastic oligodendroglioma in cerebrum. Hematoxylin & eosin stain.
17:
1637:
1535:
1477:
1012:
968:
534:
74:
1548:
1292:
1157:
1004:
960:
911:
876:
835:
759:
667:
462:
253:
118:
62:
1600:
1366:
996:
952:
903:
866:
825:
815:
751:
657:
649:
564:
556:
485:. For further treatment, radiation or chemotherapy with temozolomide or a chemotherapy with
470:
366:
257:
237:
1627:
1440:
1284:
474:
342:
568:
209:
Please help update this article to reflect recent events or newly available information.
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335:
67:
907:
755:
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1518:
1404:
1320:
1016:
972:
514:
As of 2022, a definitive cure is not possible with anaplastic oligodendrogliomas of
473:
and treat patients symptomatically. Symptomatic treatment often includes the use of
1555:
1543:
1272:
1215:
529:
524:
486:
458:
454:
445:
394:
853:
Gutin PH, Wilson CB, Kumar AR, Boldrey EB, Levin V, Powell M, Enot KJ (May 1975).
1414:
1376:
1242:
1210:
1162:
1096:
604:"Treatment Recommendations for Anaplastic Oligodendrogliomas That Are Codeleted"
494:
331:
108:
560:
549:
EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood.
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1472:
1315:
1000:
956:
653:
386:
382:
362:
354:
261:
154:
915:
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10.1002/1097-0142(197505)35:5<1398::aid-cncr2820350524>3.0.co;2-c
1234:
1182:
1073:
820:
490:
450:
390:
373:(PET). The diagnosis is confirmed by a fine tissue examination following an
338:
316:
312:
241:
164:
1008:
964:
839:
763:
671:
1041:
880:
1464:
1307:
716:[Oligodendroglioma brain tumor: causes, symptoms and treatments].
285:
265:
374:
280:
638:"The 2007 WHO classification of tumours of the central nervous system"
1392:
1225:
1068:
1053:
482:
378:
319:
327:
233:
729:"Anaplastic oligodendroglioma, IDH-mutant & 1p/19q-codeleted"
260:
III. In the course of the disease, it can degenerate into highly
778:"Survival Rates for Selected Adult Brain and Spinal Cord Tumors"
714:"Oligodendrogliom, hjärntumör: orsaker, symtom och behandlingar"
245:
1100:
1588:
WHO classification of the tumors of the central nervous system
515:
182:
361:(MRI). Occasionally, outside of routine diagnostics, the
315:) anaplastic oligodendroglioma belongs to the group of
602:
Anderson, Mark D.; Gilbert, Mark R. (April 14, 2013).
276:
Symptoms of anaplastic oligodendroglioma may include:
449:
associated with little or no pain) and the potential
421:
Zooming, note the irregular cell- and nucleus-shapes.
1031:
1580:
1508:
1486:
1463:
1433:
1389:
1359:
1329:
1306:
1283:
1233:
1224:
1204:
1195:
1171:
1143:
1134:
1035:
173:
163:
153:
145:
137:
127:
117:
107:
99:
91:
83:
73:
61:
35:
203:. The reason given is: Per the 2021 update of the
201:may be compromised due to out-of-date information
692:"highly malignant oligodendroglioma, grade IV"
1112:
8:
685:
683:
681:
1451:Embryonal tumour with multilayered rosettes
631:
629:
555:Volume 18, Number 3, 03 2021, pp. 170-186,
252:classification of brain tumors, anaplastic
1230:
1221:
1201:
1140:
1119:
1105:
1097:
1032:
597:
595:
593:
591:
589:
587:
585:
433:IDH1 R132H in anaplastic oligodendroglioma
41:
32:
870:
829:
819:
661:
1572:Malignant peripheral nerve sheath tumor
1496:Primary central nervous system lymphoma
1420:Dysembryoplastic neuroepithelial tumour
581:
537:, and type of surgery are considered).
399:
690:Radboud universitair medisch centrum.
177:0.07 to 0.18 per 100,000 person-years
7:
236:which is believed to originate from
1258:Subependymal giant cell astrocytoma
553:Nature reviews. Clinical oncology.
469:will initially pursue a course of
25:
18:Draft:Anaplastic oligodendroglioma
908:10.1200/jco.2009.27.15_suppl.2014
727:administrador (5 February 2020).
1446:Atypical teratoid rhabdoid tumor
426:
414:
402:
296:Behavior and personality changes
290:Weakness on one side of the body
187:
149:Surgery, radiation, chemotherapy
712:Sandberg, Julian (2022-03-06).
250:World Health Organization (WHO)
169:Generally fatal after 2-6 years
1540:Cranial and paraspinal nerves
1:
1253:Pleomorphic xanthoastrocytoma
1128:Tumours of the nervous system
756:10.1016/s0090-3019(03)00167-8
299:Balance and movement problems
1298:Anaplastic oligodendroglioma
896:Journal of Clinical Oncology
371:positron emission tomography
227:Anaplastic oligodendroglioma
36:Anaplastic oligodendroglioma
701:(in Dutch). pp. 46–48.
385:1 (1p) and the long arm of
381:losses on the short arm of
1654:
561:10.1038/s41571-020-00447-z
359:magnetic resonance imaging
1596:
1001:10.1007/s11060-008-9603-8
957:10.1007/s11060-007-9422-3
654:10.1007/s00401-007-0243-4
56:
40:
1425:Lhermitte–Duclos disease
1349:Choroid plexus carcinoma
1344:Choroid plexus papilloma
87:peak years are age 45-50
782:American Cancer Society
1268:Anaplastic astrocytoma
1263:Fibrillary astrocytoma
324:central nervous system
129:Differential diagnosis
1524:Esthesioneuroblastoma
1248:Pilocytic astrocytoma
821:10.1093/neuonc/nox158
293:Language difficulties
1529:Ganglioneuroblastoma
1434:CNS embryonal tumors
1339:Choroid plexus tumor
535:histological grading
1372:Gliomatosis cerebri
353:The most important
95:until cure or death
1536:Nerve sheath tumor
1478:Hemangiopericytoma
699:www.radboudumc.nl/
322:and arises in the
256:are classified as
254:oligodendrogliomas
205:WHO classification
1610:
1609:
1549:Neurofibromatosis
1504:
1503:
1459:
1458:
1385:
1384:
1293:Oligodendroglioma
1191:
1190:
1158:Craniopharyngioma
1094:
1093:
563:, PMID 33293629,
477:for seizures and
467:neuro-oncologists
463:radiation therapy
268:within a family.
224:
223:
181:
180:
119:Diagnostic method
113:Generally unknown
103:Generally unknown
79:Epilepsy-Seizures
50:
30:Medical condition
27:Human brain tumor
16:(Redirected from
1645:
1601:brain metastasis
1565:Acoustic neuroma
1367:Oligoastrocytoma
1360:Multiple/unknown
1231:
1222:
1202:
1176:
1151:
1141:
1121:
1114:
1107:
1098:
1033:
1021:
1020:
983:
977:
976:
940:
934:
933:
926:
920:
919:
891:
885:
884:
874:
850:
844:
843:
833:
823:
799:
793:
792:
790:
788:
774:
768:
767:
739:
733:
732:
724:
718:
717:
709:
703:
702:
696:
687:
676:
675:
665:
642:Acta Neuropathol
633:
624:
623:
621:
619:
599:
471:watchful waiting
453:associated with
430:
418:
406:
343:oligodendrocytes
302:Memory problems.
238:oligodendrocytes
219:
216:
210:
199:factual accuracy
191:
190:
183:
52:
51:
33:
21:
1653:
1652:
1648:
1647:
1646:
1644:
1643:
1642:
1633:Types of cancer
1613:
1612:
1611:
1606:
1605:
1592:
1576:
1500:
1482:
1455:
1441:Medulloblastoma
1429:
1391:
1381:
1355:
1325:
1302:
1285:Oligodendrocyte
1279:
1214:
1208:
1206:Neuroepithelial
1187:
1172:
1167:
1144:
1130:
1125:
1095:
1090:
1089:
1044:
1030:
1025:
1024:
985:
984:
980:
942:
941:
937:
928:
927:
923:
893:
892:
888:
865:(5): 1398–404.
852:
851:
847:
801:
800:
796:
786:
784:
776:
775:
771:
741:
740:
736:
726:
725:
721:
711:
710:
706:
694:
689:
688:
679:
635:
634:
627:
617:
615:
601:
600:
583:
578:
543:
512:
503:
475:anticonvulsants
441:
434:
431:
422:
419:
410:
407:
369:is shown using
351:
309:
274:
231:neuroepithelial
220:
214:
211:
208:
196:This article's
192:
188:
42:
31:
28:
23:
22:
15:
12:
11:
5:
1651:
1649:
1641:
1640:
1635:
1630:
1625:
1615:
1614:
1608:
1607:
1597:
1594:
1593:
1591:
1590:
1584:
1582:
1578:
1577:
1575:
1574:
1569:
1568:
1567:
1553:
1552:
1551:
1546:
1538:
1533:
1532:
1531:
1526:
1515:
1513:
1506:
1505:
1502:
1501:
1499:
1498:
1492:
1490:
1484:
1483:
1481:
1480:
1475:
1469:
1467:
1461:
1460:
1457:
1456:
1454:
1453:
1448:
1443:
1437:
1435:
1431:
1430:
1428:
1427:
1422:
1417:
1412:
1410:Retinoblastoma
1407:
1401:Ganglioneuroma
1397:
1395:
1387:
1386:
1383:
1382:
1380:
1379:
1374:
1369:
1363:
1361:
1357:
1356:
1354:
1353:
1352:
1351:
1346:
1335:
1333:
1331:Choroid plexus
1327:
1326:
1324:
1323:
1318:
1312:
1310:
1304:
1303:
1301:
1300:
1295:
1289:
1287:
1281:
1280:
1278:
1277:
1276:
1275:
1270:
1265:
1260:
1255:
1250:
1239:
1237:
1228:
1219:
1199:
1193:
1192:
1189:
1188:
1186:
1185:
1179:
1177:
1169:
1168:
1166:
1165:
1160:
1154:
1152:
1138:
1132:
1131:
1126:
1124:
1123:
1116:
1109:
1101:
1092:
1091:
1088:
1087:
1076:
1061:
1045:
1040:
1039:
1037:
1036:Classification
1029:
1028:External links
1026:
1023:
1022:
978:
935:
921:
886:
845:
814:(S5): v1–v88.
808:Neuro-Oncology
794:
769:
734:
719:
704:
677:
625:
580:
579:
577:
574:
573:
572:
542:
539:
511:
508:
502:
499:
483:brain swelling
440:
437:
436:
435:
432:
425:
423:
420:
413:
411:
408:
401:
350:
347:
308:
305:
304:
303:
300:
297:
294:
291:
288:
283:
273:
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222:
221:
195:
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186:
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170:
167:
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157:
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147:
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139:
135:
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131:
125:
124:
121:
115:
114:
111:
105:
104:
101:
97:
96:
93:
89:
88:
85:
81:
80:
77:
71:
70:
68:Neuro-oncology
65:
59:
58:
54:
53:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
1650:
1639:
1636:
1634:
1631:
1629:
1626:
1624:
1621:
1620:
1618:
1604:
1602:
1595:
1589:
1586:
1585:
1583:
1579:
1573:
1570:
1566:
1563:
1562:
1561:
1557:
1554:
1550:
1547:
1545:
1542:
1541:
1539:
1537:
1534:
1530:
1527:
1525:
1522:
1521:
1520:
1519:Neuroblastoma
1517:
1516:
1514:
1511:
1507:
1497:
1494:
1493:
1491:
1489:
1488:Hematopoietic
1485:
1479:
1476:
1474:
1471:
1470:
1468:
1466:
1462:
1452:
1449:
1447:
1444:
1442:
1439:
1438:
1436:
1432:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1405:Ganglioglioma
1402:
1399:
1398:
1396:
1394:
1388:
1378:
1375:
1373:
1370:
1368:
1365:
1364:
1362:
1358:
1350:
1347:
1345:
1342:
1341:
1340:
1337:
1336:
1334:
1332:
1328:
1322:
1321:Subependymoma
1319:
1317:
1314:
1313:
1311:
1309:
1305:
1299:
1296:
1294:
1291:
1290:
1288:
1286:
1282:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1245:
1244:
1241:
1240:
1238:
1236:
1232:
1229:
1227:
1223:
1220:
1217:
1216:spinal tumors
1212:
1207:
1203:
1200:
1198:
1194:
1184:
1181:
1180:
1178:
1175:
1170:
1164:
1161:
1159:
1156:
1155:
1153:
1150:
1148:
1142:
1139:
1137:
1133:
1129:
1122:
1117:
1115:
1110:
1108:
1103:
1102:
1099:
1086:
1082:
1081:
1077:
1075:
1071:
1070:
1066:
1062:
1060:
1056:
1055:
1051:
1047:
1046:
1043:
1038:
1034:
1027:
1018:
1014:
1010:
1006:
1002:
998:
995:(2): 187–93.
994:
990:
989:J. Neurooncol
982:
979:
974:
970:
966:
962:
958:
954:
951:(3): 319–28.
950:
946:
945:J. Neurooncol
939:
936:
931:
925:
922:
917:
913:
909:
905:
902:(15S): 2014.
901:
897:
890:
887:
882:
878:
873:
868:
864:
860:
856:
849:
846:
841:
837:
832:
827:
822:
817:
813:
809:
805:
798:
795:
783:
779:
773:
770:
765:
761:
757:
753:
750:(5): 443–56.
749:
745:
738:
735:
730:
723:
720:
715:
708:
705:
700:
693:
686:
684:
682:
678:
673:
669:
664:
659:
655:
651:
648:(2): 97–109.
647:
643:
639:
632:
630:
626:
613:
609:
605:
598:
596:
594:
592:
590:
588:
586:
582:
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570:
566:
562:
558:
554:
550:
545:
544:
540:
538:
536:
531:
526:
521:
517:
509:
507:
500:
498:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
447:
438:
429:
424:
417:
412:
405:
400:
398:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
357:procedure is
356:
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530:neurosurgeon
525:temozolomide
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487:Procarbazine
459:chemotherapy
455:neurosurgery
446:brain tissue
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395:chemotherapy
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307:Pathogenesis
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159:Temozolomide
109:Risk factors
1623:Brain tumor
1415:Neurocytoma
1377:Gliosarcoma
1243:Astrocytoma
1163:Pituicytoma
744:Surg Neurol
495:Vincristine
332:spinal cord
266:inheritance
215:August 2021
84:Usual onset
1617:Categories
1560:Schwannoma
1473:Meningioma
1316:Ependymoma
576:References
541:Literature
387:chromosome
383:chromosome
363:metabolism
355:diagnostic
339:stem cells
155:Medication
138:Prevention
1638:Neurology
1235:Astrocyte
1183:Pinealoma
1136:Endocrine
916:0732-183X
787:8 January
618:4 January
571:(Review).
501:Prognosis
451:morbidity
439:Treatment
391:radiation
375:operation
349:Diagnosis
336:precursor
313:malignant
262:malignant
248:. In the
242:cell type
174:Frequency
165:Prognosis
146:Treatment
141:Not known
63:Specialty
1465:Meninges
1308:Ependyma
1017:30666549
1009:18458821
973:27456056
965:17568995
840:29117289
764:14572971
672:17618441
608:Oncology
510:Research
479:steroids
286:Headache
272:Symptoms
92:Duration
75:Symptoms
1085:M9382/3
1059:2A00.0Y
881:1122488
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465:, most
365:in the
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367:tissue
320:glioma
123:Biopsy
100:Causes
1581:Other
1080:ICD-O
1013:S2CID
969:S2CID
695:(PDF)
328:brain
311:The (
258:grade
234:tumor
229:is a
1005:PMID
961:PMID
912:ISSN
877:PMID
836:PMID
789:2021
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620:2021
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520:ASCO
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