308:
285:
182:
207:
314:
213:
1231:
1288:
1495:
markers. XB130 protein level was elevated in human esophageal squamous carcinoma. In addition, XB130 was selected as one of six highly expressed genes related to local aggressiveness of soft tissue tumors in a set of 102 representative tumor samples. These findings suggest that XB130 may be involved
1470:
Adaptor proteins play an important role as molecular scaffolds to mediate the transport and interaction of various proteins and is therefore highly involved in signal transduction. Deregulation of adaptor proteins is highly related to the abnormality of cellular functions and many adaptor proteins
61:
2087:
Shiozaki A, Kosuga T, Ichikawa D, Komatsu S, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Shimizu H, Ishimoto T, Kitagawa M, Nakou Y, Kishimoto M, Liu M, Otsuji E (2013). "XB130 as an independent prognostic factor in human esophageal squamous cell carcinoma".
1214:. XB130 is highly similar to AFAP and is thus known as actin filament associated protein 1-like 2 (AFAP1L2). XB130 is a substrate and regulator of multiple tyrosine kinase-mediated signaling. XB130 is highly expressed in the
1487:/insular carcinoma. Through the studies on many gastrointestinal cancers, the oncogenic roles of XB130 was shown. XB130 expression is significantly correlated with the survival time and disease-free period in
1820:
Saini KS, Loi S, de
Azambuja E, Metzger-Filho O, Saini ML, Ignatiadis M, Dancey JE, Piccart-Gebhart MJ (2013). "Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer".
1516:, Canada. The molecule is named XB130 after lead technician Xiaohui Bai and the molecular mass of the protein. This protein was found to have a high sequence identity to AFAP1, thus its name AFAP1L2.
1471:
are frequently overexpressed in cancers. Clinical studies on the expression level and pattern of XB130 in various human tumors demonstrate that XB130 expression is regulated in thyroid and
1274:. Despite XB130's structural similarity to AFAP, XB130 does not behave like an actin filament-associated protein. The actin-binding site present in AFAP is only partially present in XB130.
1410:
and SRE transcription factor binding sites. These binding sites can be activated by the downregulation of XB130 expression and lead to a decrease in IL-8 production in lung cells.
321:
220:
1307:. This interaction leads to the subsequent activation of Akt, cell proliferation, and cell survival. Activated Akt promotes cell survival and cell cycle progression by
1512:
This adaptor protein was discovered during molecular cloning of human actin filament associated protein (AFAP1) in the Latner
Thoracic Surgery Research Laboratories
1343:, Akt phosphorylation and therefore activation becomes significantly reduced. This, in turn, leads to cell cycle arrest at G1/S phase and accelerated apoptosis.
1718:
Lodyga M, Bai XH, Kapus A, Liu M (2010). "Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion".
1430:
1399:
768:
749:
143:
2134:
Cunha IW, Carvalho KC, Martins WK, Marques SM, Muto NH, Falzoni R, Rocha RM, Aguiar S, Simoes AC, Fahham L, Neves EJ, Soares FA, Reis LF (2010).
1592:
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1574:
307:
1136:
1203:
1143:
284:
2191:
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1540:
1287:
1303:
signaling pathway. When tyrosine phosphorylated, XB130 has the ability to interact with the p85ɑ subunit of PI3K through its
206:
181:
1557:
58:
1383:
The level of XB130 expression influences the expression of multiple genes related to cell proliferation and survival, and
1254:
region of XB130, which allows it to interact and activate c-Src-containing proteins, as well as bind to p85α of PI3K. Two
1536:
123:
1250:) and is thus known as AFAP1L2. Several tyrosine phosphorylation sites and a proline rich sequence are included in the
1247:
320:
219:
1419:
313:
212:
1452:
1666:"AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes"
1407:
1255:
813:
131:
2136:"Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors"
1472:
1295:
XB130 has been demonstrated to play a role in cell proliferation and survival through the regulation of the
794:
1763:"XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt"
1371:
of XB130 to the cell periphery is particularly important in its potential to influence cell migration and
1368:
1267:
1239:
195:
1984:
1922:
1774:
110:
1860:
Shiozaki A, Lodyga M, Bai XH, Nadesalingam J, Oyaizu T, Winer D, Asa SL, Keshavjee S, Liu M (2011).
1479:
tumors. Expression level of XB130 was significantly higher in normal and benign lesion than that of
1911:"XB130, a new adaptor protein, regulates expression of tumor suppressive microRNAs in cancer cells"
1207:
1115:
1111:
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903:
893:
889:
881:
877:
2113:
1973:"Silencing of XB130 is associated with both the prognosis and chemosensitivity of gastric cancer"
1743:
1304:
1266:
domain. Both the C-terminal and N-terminal regions of XB130 are required for XB130's role in its
155:
1119:
1016:
988:
885:
2165:
2105:
2066:
2012:
1950:
1891:
1837:
1802:
1735:
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1492:
1390:, 149a, and 193a-3p, all of which exhibit tumor suppressive function in thyroid cancer cells.
103:
51:
151:
2155:
2147:
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2002:
1992:
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331:
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1761:
Shiozaki A, Shen-Tu G, Bai X, Iitaka D, De Falco V, Santoro M, Keshavjee S, Liu M (2012).
1458:
1359:, XB130 translocates to the cell periphery. XB130 exhibits a high affinity for peripheral
1308:
1211:
375:
1988:
1926:
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2160:
2135:
2061:
2034:
2007:
1972:
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1263:
1909:
Takeshita H, Shiozaki A, Bai XH, Iitaka D, Kim H, Yang BB, Keshavjee S, Liu M (2013).
1242:
and encodes an 818 amino acid protein. It has a molecular weight of approximately 130
683:
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578:
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1971:
Shi M, Huang W, Lin L, Zheng D, Zuo Q, Wang L, Wang N, Wu Y, Liao Y, Liao W (2012).
1747:
135:
1352:
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393:
172:
1262:
region contains a coiled-coil domain, which shares partial similarity with AFAP's
17:
1997:
1935:
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1787:
159:
1597:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1579:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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1258:
are located in the middle portion, giving XB130 its lipid-binding ability. The
1210:
mediator. XB130 regulates cell proliferation, cell survival, cell motility and
476:
2101:
1484:
1435:
1426:
1372:
1339:, respectively.> Alternatively, when the expression of XB130 is suppressed
1336:
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713:
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2016:
1954:
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1841:
1806:
1739:
1699:
1650:
114:, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2
2051:
1183:
1178:
1384:
1356:
1320:
1167:
858:
839:
664:
positive regulation of epidermal growth factor receptor signaling pathway
2035:"Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells"
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1447:
1360:
1215:
825:
780:
2151:
80:
1406:(IL-8), a chemokine produce by lung epithelial cells, which contains
1387:
1316:
1219:
1151:
735:
1286:
1246:
and is structurally similar to actin-filament-associated protein (
1229:
698:
694:
1664:
Snyder BN, Cho Y, Qian Y, Coad JE, Flynn DC, Cunnick JM (2011).
1335:, which are involved in the extrinsic and intrinsic pathways of
1296:
127:
1862:"XB130, a novel adaptor protein, promotes thyroid tumor growth"
1617:"XB130: A novel adaptor protein in cancer signal transduction"
1312:
1300:
2033:
Emaduddin M, Edelmann MJ, Kessler BM, Feller SM (2008).
383:
684:
positive regulation of protein tyrosine kinase activity
548:
1291:
Roles of XB130 in cell cycle and survival of cancer.
1234:
Schematic representation of XB130 protein structure
1104:
1007:
973:
876:
649:
positive regulation of transcription, DNA-templated
2186:Roles of XB130, a novel adaptor protein, in cancer
1553:
1551:
1549:
1532:
1530:
1528:
330:
229:
669:positive regulation of interleukin-8 production
27:Protein-coding gene in the species Homo sapiens
1615:Zhang R, Zhang J, Wu Q, Meng F, Liu C (2016).
1558:GRCm38: Ensembl release 89: ENSMUSG00000025083
1491:patients. XB130 was identified as a potential
1238:The XB130 gene is located on human chromosome
8:
2028:
2026:
1537:GRCh38: Ensembl release 89: ENSG00000169129
1355:rearrangement, a process required for cell
2082:
2080:
1004:
873:
709:
602:protein tyrosine kinase activator activity
574:
371:
270:
167:
69:
2200:studies of a novel signal adaptor protein
2159:
2060:
2050:
2006:
1996:
1944:
1934:
1885:
1796:
1786:
1689:
1640:
1500:and that XB130 is a potential diagnostic
2129:
2127:
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1713:
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1966:
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679:regulation of interleukin-6 production
29:
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335:
296:
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234:
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7:
1504:and therapeutic target for cancer.
1347:Role in cell motility and invasion
1101:
970:
849:
830:
804:
785:
759:
740:
553:
471:
409:
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25:
1866:The American Journal of Pathology
1402:binding and activation increases
659:regulation of signal transduction
2039:Cell Communication and Signaling
1670:European Journal of Cell Biology
674:regulation of mitotic cell cycle
319:
312:
306:
283:
218:
211:
205:
180:
1418:XB130 (gene) has been known to
1283:Role in cell cycle and survival
1327:by preventing the cleavage of
537:More reference expression data
457:right hemisphere of cerebellum
1:
304:
203:
2216:Genes on human chromosome 10
1998:10.1371/journal.pone.0041660
1936:10.1371/journal.pone.0059057
1878:10.1016/j.ajpath.2010.11.024
1788:10.1371/journal.pone.0043646
2090:Annals of Surgical Oncology
1256:pleckstrin-homology domains
433:right lobe of thyroid gland
2232:
1834:10.1016/j.ctrv.2013.03.009
1682:10.1016/j.ejcb.2010.11.016
1453:GTPase-activating proteins
607:signaling adaptor activity
429:left lobe of thyroid gland
2102:10.1245/s10434-012-2474-4
1593:"Mouse PubMed Reference:"
1575:"Human PubMed Reference:"
1182:
1177:
1173:
1166:
1150:
1137:Chr 10: 114.29 – 114.4 Mb
1131:
1108:
1031:
1000:
977:
900:
869:
856:
852:
837:
833:
824:
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1822:Cancer Treatment Reviews
1363:structures, such as the
1144:Chr 19: 56.91 – 57.01 Mb
1720:Journal of Cell Science
1473:gastrointestinal cancer
1379:Role in gene expression
511:external carotid artery
2140:Translational Oncology
1323:, as well as inhibits
1292:
1235:
2052:10.1186/1478-811X-6-7
1466:Clinical significance
1290:
1233:
654:inflammatory response
453:cerebellar hemisphere
298:Chromosome 19 (mouse)
196:Chromosome 10 (human)
1444:p85a subunit of PI3K
1394:Role in inflammation
73:List of PDB id codes
46:Available structures
1989:2012PLoSO...741660S
1927:2013PLoSO...859057T
1779:2012PLoSO...743646S
1633:10.3892/br.2016.588
1226:Molecular structure
1208:signal transduction
461:canal of the cervix
160:AFAP1L2 - orthologs
1732:10.1242/jcs.071050
1726:(Pt 23): 4156–69.
1621:Biomedical Reports
1293:
1236:
814:ENSMUSG00000025083
642:Biological process
616:Cellular component
597:SH2 domain binding
592:SH3 domain binding
585:Molecular function
449:right uterine tube
441:buccal mucosa cell
18:Draft:XB130 (gene)
2202:. (PDF) A thesis.
2152:10.1593/tlo.09166
1493:colorectal cancer
1398:XB130 mediated c-
1311:and inactivating
1202:) is a cytosolic
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56:Ortholog search:
16:(Redirected from
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1514:Toronto, Ontario
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1001:RefSeq (protein)
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2180:Further reading
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1459:Phospholipase C
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1309:phosphorylating
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1228:
1212:gene expression
1204:adaptor protein
1198:(also known as
1184:View/Edit Mouse
1179:View/Edit Human
1142:
1135:
1132:Location (UCSC)
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2096:(9): 3140–50.
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1872:(1): 391–401.
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1627:(3): 300–306.
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1489:gastric cancer
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1461:-gamma (PLC-γ)
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1264:leucine zipper
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2029:
2027:
2023:
2018:
2014:
2009:
2004:
1999:
1994:
1990:
1986:
1983:(8): e41660.
1982:
1978:
1974:
1967:
1965:
1961:
1956:
1952:
1947:
1942:
1937:
1932:
1928:
1924:
1921:(3): e59057.
1920:
1916:
1912:
1905:
1902:
1897:
1893:
1888:
1883:
1879:
1875:
1871:
1867:
1863:
1856:
1854:
1852:
1848:
1843:
1839:
1835:
1831:
1828:(8): 935–46.
1827:
1823:
1816:
1813:
1808:
1804:
1799:
1794:
1789:
1784:
1780:
1776:
1773:(8): e43646.
1772:
1768:
1764:
1757:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1725:
1721:
1714:
1712:
1710:
1706:
1701:
1697:
1692:
1687:
1683:
1679:
1676:(5): 376–89.
1675:
1671:
1667:
1660:
1657:
1652:
1648:
1643:
1638:
1634:
1630:
1626:
1622:
1618:
1611:
1609:
1607:
1603:
1598:
1594:
1588:
1585:
1580:
1576:
1570:
1567:
1563:
1559:
1554:
1552:
1550:
1546:
1542:
1538:
1533:
1531:
1529:
1525:
1519:
1517:
1515:
1507:
1505:
1503:
1499:
1498:tumorigenesis
1494:
1490:
1486:
1482:
1478:
1474:
1465:
1460:
1457:
1454:
1451:
1449:
1446:
1443:
1440:
1437:
1434:
1432:
1428:
1425:
1424:
1423:
1421:
1413:
1411:
1409:
1405:
1404:Interleukin-8
1401:
1393:
1391:
1389:
1386:
1378:
1376:
1374:
1370:
1369:translocation
1366:
1365:lamellipodium
1362:
1358:
1354:
1346:
1344:
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1310:
1306:
1302:
1298:
1289:
1282:
1277:
1275:
1273:
1269:
1268:translocation
1265:
1261:
1257:
1253:
1249:
1245:
1241:
1232:
1225:
1223:
1221:
1217:
1213:
1209:
1205:
1201:
1197:
1185:
1180:
1176:
1172:
1169:
1165:
1158:
1156:
1153:
1149:
1145:
1141:
1138:
1134:
1130:
1123:
1121:
1117:
1113:
1107:
1103:
1100:
1094:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1040:
1036:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1003:
999:
992:
990:
986:
982:
976:
972:
969:
963:
961:
957:
953:
949:
945:
941:
937:
933:
929:
925:
921:
917:
913:
909:
905:
899:
895:
891:
887:
883:
879:
875:
872:
870:RefSeq (mRNA)
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
810:
806:
803:
797:
796:
791:
787:
784:
782:
778:
771:
770:
765:
761:
758:
752:
751:
746:
742:
739:
737:
733:
730:
727:
725:
722:
718:
715:
711:
707:
700:
696:
691:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
646:
644:
641:
640:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
608:
605:
603:
600:
598:
595:
593:
590:
589:
587:
584:
583:
580:
579:Gene ontology
576:
572:
560:
555:
552:
550:
546:
538:
533:
522:
518:
514:
510:
507:sciatic nerve
506:
502:
499:otolith organ
498:
494:
490:
486:
485:
482:
478:
473:
470:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
423:
420:
416:
411:
408:
407:
404:
402:
398:
396:
395:
391:
390:
387:
385:
381:
377:
373:
369:
361:
356:
352:
348:
343:
337:19|19 D2
333:
329:
322:
315:
309:
302:
294:
290:
286:
281:
277:
272:
268:
260:
255:
251:
247:
242:
232:
228:
221:
214:
208:
201:
197:
191:
187:
183:
178:
174:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
117:
112:
105:
100:
95:
84:
82:
76:
71:
68:
67:
63:
60:
53:
49:
44:
40:
36:
31:
19:
2197:
2193:
2146:(1): 23–32.
2143:
2139:
2093:
2089:
2042:
2038:
1980:
1976:
1918:
1914:
1904:
1869:
1865:
1825:
1821:
1815:
1770:
1766:
1756:
1723:
1719:
1673:
1669:
1659:
1624:
1620:
1596:
1587:
1578:
1569:
1511:
1469:
1417:
1414:Interactions
1397:
1382:
1353:cytoskeletal
1350:
1340:
1294:
1272:lamellipodia
1237:
1199:
1195:
1194:
1116:NP_001171268
1112:NP_001171267
1109:
1091:NP_001338009
1087:NP_001338008
1083:NP_001338007
1079:NP_001338006
1075:NP_001338005
1071:NP_001338004
1067:NP_001338003
1063:NP_001338002
1059:NP_001338001
1055:NP_001338000
1051:NP_001337999
1047:NP_001337998
1043:NP_001337997
1039:NP_001337996
1035:NP_001337995
1032:
1025:NP_001337994
1021:NP_001337993
1013:NP_001274753
1009:NP_001001936
985:NM_001177797
981:NM_001177796
978:
960:NM_001351080
956:NM_001351079
952:NM_001351078
948:NM_001351077
944:NM_001351076
940:NM_001351075
936:NM_001351074
932:NM_001351073
928:NM_001351072
924:NM_001351071
920:NM_001351070
916:NM_001351069
912:NM_001351068
908:NM_001351067
904:NM_001351066
901:
894:NM_001351065
890:NM_001351064
882:NM_001287824
878:NM_001001936
857:
838:
812:
793:
767:
748:
728:
723:
399:
392:
257:114,404,756
244:114,294,824
119:External IDs
78:
2188:. A review.
1477:soft tissue
1315:Cip1/WAF1,
1305:SH2 domains
425:sural nerve
358:57,008,228
345:56,912,361
97:Identifiers
1564:, May 2017
1543:, May 2017
1520:References
1485:anaplastic
1436:SH3 domain
1427:SH2 domain
1373:metastasis
1337:cell death
1319:Kip1, and
1260:C-terminal
1252:N-terminal
403:(ortholog)
140:HomoloGene
2194:in silico
1508:Discovery
1502:biomarker
1481:papillary
1385:microRNAs
1333:caspase-9
1329:caspase-8
1325:apoptosis
1120:NP_666214
1017:NP_115939
989:NM_146102
886:NM_032550
714:Orthologs
623:cytoplasm
148:GeneCards
2210:Category
2170:20165692
2118:10246459
2110:22805860
2071:18844995
2017:22927913
1977:PLOS ONE
1955:23527086
1915:PLOS ONE
1896:21224076
1842:23643661
1807:22928011
1767:PLOS ONE
1748:17993293
1740:21084565
1700:21333378
1651:26998266
1560:–
1539:–
1420:interact
1357:motility
1341:in vitro
1278:Function
1168:Wikidata
693:Sources:
523:gastrula
2198:in vivo
2192:XB130:
2161:2822450
2062:2584000
2008:3426513
1985:Bibcode
1946:3602428
1923:Bibcode
1887:3070596
1798:3426539
1775:Bibcode
1691:3085893
1642:4774376
1562:Ensembl
1541:Ensembl
1448:RET/PTC
1388:miR-33a
1361:F-actin
1351:During
1270:to the
1240:10q25.3
1216:thyroid
1200:AFAP1L2
826:UniProt
781:Ensembl
720:Species
699:QuickGO
633:cytosol
515:decidua
503:utricle
378:pattern
236:10q25.3
152:AFAP1L2
136:2147658
111:AFAP1L2
104:Aliases
33:AFAP1L2
2168:
2158:
2116:
2108:
2069:
2059:
2015:
2005:
1953:
1943:
1894:
1884:
1840:
1805:
1795:
1746:
1738:
1698:
1688:
1649:
1639:
1438:of Src
1367:. The
1220:spleen
1154:search
1152:PubMed
859:Q5DTU0
840:Q8N4X5
769:226250
736:Entrez
549:BioGPS
495:zygote
437:spleen
128:612420
2114:S2CID
2045:: 7.
1744:S2CID
1455:(GAP)
1441:c-Src
1422:with
1321:GSK3β
1196:XB130
750:84632
729:Mouse
724:Human
695:Amigo
401:Mouse
394:Human
341:Start
276:Mouse
240:Start
173:Human
144:13057
2196:and
2166:PMID
2106:PMID
2067:PMID
2013:PMID
1951:PMID
1892:PMID
1838:PMID
1803:PMID
1736:PMID
1696:PMID
1647:PMID
1483:and
1475:and
1408:AP-1
1331:and
1297:PI3K
1248:AFAP
1218:and
1206:and
384:Bgee
332:Band
293:Chr.
231:Band
190:Chr.
124:OMIM
81:2COF
62:RCSB
59:PDBe
2156:PMC
2148:doi
2098:doi
2057:PMC
2047:doi
2003:PMC
1993:doi
1941:PMC
1931:doi
1882:PMC
1874:doi
1870:178
1830:doi
1793:PMC
1783:doi
1728:doi
1724:123
1686:PMC
1678:doi
1637:PMC
1629:doi
1496:in
1431:Src
1429:of
1400:Src
1317:p27
1313:p21
1301:Akt
1244:kDa
557:n/a
354:End
253:End
156:OMA
132:MGI
52:PDB
2212::
2164:.
2154:.
2142:.
2138:.
2126:^
2112:.
2104:.
2094:20
2092:.
2079:^
2065:.
2055:.
2041:.
2037:.
2025:^
2011:.
2001:.
1991:.
1979:.
1975:.
1963:^
1949:.
1939:.
1929:.
1917:.
1913:.
1890:.
1880:.
1868:.
1864:.
1850:^
1836:.
1826:39
1824:.
1801:.
1791:.
1781:.
1769:.
1765:.
1742:.
1734:.
1722:.
1708:^
1694:.
1684:.
1674:90
1672:.
1668:.
1645:.
1635:.
1623:.
1619:.
1605:^
1595:.
1577:.
1548:^
1527:^
1375:.
1222:.
697:/
360:bp
347:bp
259:bp
246:bp
154:;
150::
146:;
142::
138:;
134::
130:;
126::
2172:.
2150::
2144:3
2120:.
2100::
2073:.
2049::
2043:6
2019:.
1995::
1987::
1981:7
1957:.
1933::
1925::
1919:8
1898:.
1876::
1844:.
1832::
1809:.
1785::
1777::
1771:7
1750:.
1730::
1702:.
1680::
1653:.
1631::
1625:4
1599:.
1581:.
1299:/
278:)
175:)
158::
20:)
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