289:
266:
38:
524:
6-oxoprostaglandin F1a, a stable metabolite of prostacyclin. Prostacyclin is a potent vasodilator, and may be implicated in reperfusion; it is also a disaggregator of platelets. Whereas prostaglandins themselves may have a role in regulating cerebral blood flow, etamsylate appears to have no effect on cerebral blood flow. Etamsylate was also thought to stabilize capillaries, reinforcing capillary membranes by polymerizing
29:
534:
Etamsylate may also have an effect on the microcirculation, encouraging platelet aggregation and vasoconstriction and therefore haemostasis. It also inhibits the effects of the prostaglandin mediated vasodilatation and increased capillary permeability, thereby reducing oedema secondary to capillary
538:
By inhibiting the effects of prostaglandins, etamsylate may exert an effect by closing the patent ductus and thereby increasing cerebral blood flow. Further, etamsylate has demonstrated interference with heparin, antagonizing its pro-hemorrhagic and anti-coagulant effects, without inhibiting its
491:
Prophylaxis and control of haemorrhages from small blood vessels, neonatal intraventricular haemorrhage, capillary bleeding of different etiology, including: menorrhagia and metrorrhagia without organic pathology, after trans-urethral resection of the prostate, hematemesis, melena, hematuria,
523:
of etamsylate is unknown. It has been shown to reduce bleeding time and blood loss from wounds. This appears to relate to increased platelet aggregation mediated by a thromboxane A2 or prostaglandin F2a dependent mechanism. It has also been associated with decreased concentrations of
906:
Cobo-Nuñez MY, El Assar M, Cuevas P, Sánchez-Ferrer A, Martínez-González J, Rodríguez-Mañas L, Angulo J (May 2018). "Haemostatic agent etamsylate in vitro and in vivo antagonizes anti-coagulant activity of heparin".
871:
Perlman JM, Hill A, Volpe JJ (November 1981). "The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: ductal steal in the premature newborn infant".
86:
416:
508:
and their release from bone marrow. Haemostatic action is due to activation of thromboplastin formation on damaged sites of small blood vessels and decrease of PgI2 (
492:
epistaxis; secondary bleeding due to thrombocytopenia or thrombocytopathia, hypocoagulation, prevention of periventricular hemorrhages in prematurely born children.
68:
372:
968:
1404:
1281:
797:
Circulation of medicines, Federal State
Institution "Scientific Center for Expertise of Medical Products" of Roszdravnadzor of the Russian Federation
531:
Etamsylate limits capillary bleeding through its action on hyaluronic acid and initial studies showed a reduction in intraventricular haemorrhage.
535:
leakage. It is also possible that etamsylate would reduce reperfusion haemorrhage in ischaemic areas of the brain, preventing secondary damage.
711:
358:
392:
657:
Kovács L, Falkay G (November 1981). "Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro".
799:] (in Russian). ФГУ «Научный центр экспертизы средств медицинского применения» Росздравнадзора РФ. 2008-03-27. Archived from
1199:
1154:
561:"Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial"
119:
1758:
1291:
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205:
727:
245:
1086:
1768:
1636:
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756:
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284:
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37:
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501:
400:
InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
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301:
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Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005).
214:
194:
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Elbourne D, Ayers S, Dellagrammaticas H, Johnson A, Leloup M, Lenoir-Piat S (May 2001).
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476:
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1752:
1471:
1466:
1456:
1225:
1220:
1178:
1020:
936:
610:"Randomised controlled trial of prophylactic etamsylate: follow up at 2 years of age"
461:
277:
686:
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1481:
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1417:
1354:
1210:
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Diethylammonium 2,5-dihydroxybenzenesulfonate; diethylammonium dobesilate
1382:
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1598:
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670:
160:
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1338:
706:(36th ed.). London; Chicago: Pharmaceuticale Press, PhP. 2009.
234:
1690:
800:
357:
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agent which is believed to work by increasing resistance in the
225:
1386:
950:
828:
Archives of
Disease in Childhood. Fetal and Neonatal Edition
614:
Archives of
Disease in Childhood. Fetal and Neonatal Edition
565:
Archives of
Disease in Childhood. Fetal and Neonatal Edition
250:
824:"Etamsylate for prevention of periventricular haemorrhage"
512:) synthesis; it also facilitates platelet aggregation and
775:[Search in the drug database, search options: INN -
516:, that at last induce decrease and stop of hemorrhage.
423:
55:
Cyclonamine, Dicynene, Dicynone, Haemostop, Menostat
1719:
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110:
85:
67:
59:
49:
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696:
500:Etamsylate is a haemostatic agent; also promotes
173:
148:
757:"Поиск по базе данных ЛС, опции поиска: МНН —
554:
552:
1398:
962:
8:
781:"Search in the register of registered drugs"
19:
16:Chemical compound used as an antihemorrhagic
1676:
1569:
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1405:
1391:
1383:
1008:
1001:
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947:
287:
264:
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27:
1282:Tetragalacturonic acid hydroxymethylester
847:
633:
584:
213:
763:"Искать в реестре зарегистрированных ЛС"
704:Martindale: The complete drug reference
548:
504:and proaggregant action. It stimulates
397:
377:
260:
124:
468:and increased capillary permeability.
278:
18:
1614:sclerosing agents for local injection
464:which cause platelet disaggregation,
77:
7:
98:
233:
164:
127:2,5-Dihydroxybenzenesulfonic acid;
732:Bulgarian Pharmaceutical Group Ltd
14:
1157:(II, VII, IX, X, protein C and S)
909:European Journal of Pharmacology
318:
312:
1200:thrombopoietin receptor agonist
1155:Prothrombin complex concentrate
793:Обращение лекарственных средств
405:Key:HBGOLJKPSFNJSD-UHFFFAOYSA-N
1292:Hemostatic Powder Spray TC-325
380:CCNCC.c1cc(c(cc1O)S(=O)(=O)O)O
327:
321:
306:
1:
885:10.1016/S0022-3476(81)80408-8
1673:Capillary stabilising agents
921:10.1016/j.ejphar.2018.03.028
456:adhesion. It also inhibits
1785:
1087:Valoctocogene roxaparvovec
728:"Pharmacynon (Etamsylate)"
296:Chemical and physical data
1637:Sodium tetradecyl sulfate
1248:Absorbable gelatin sponge
873:The Journal of Pediatrics
539:vasodilatory properties.
413:
388:
368:
115:
35:
26:
1097:Fidanacogene elaparvovec
822:Hunt RW (January 2005).
79:International Drug Names
1622:Monoethanolamine oleate
1331:Aminomethylbenzoic acid
840:10.1136/adc.2003.045625
577:10.1136/adc.2003.035790
1477:Fluocinolone acetonide
1759:Benzenesulfonic acids
1063:Damoctocog alfa pegol
771:"Показывать лекформы"
1632:Inverted sugar syrup
1604:Pentosan polysulfate
626:10.1136/fn.84.3.F183
460:and action of those
803:on 3 September 2011
521:mechanism of action
496:Mechanism of action
436:(sometimes spelled
23:
1660:Calcium dobesilate
1277:Oxidized cellulose
1067:Efanesoctocog alfa
671:10.1007/BF01989908
471:Etamsylate is the
1746:
1745:
1742:
1741:
1668:
1667:
1589:Organo-heparinoid
1558:
1557:
1493:local anesthetics
1427:Antihemorrhoidals
1380:
1379:
1350:Alfa1 antitrypsin
1321:Aminocaproic acid
1306:Antifibrinolytics
1300:
1299:
1236:
1235:
1071:Efmoroctocog alfa
1021:Phytomenadione (K
713:978-0-85369-840-1
665:(11): 1182–1183.
431:
430:
359:Interactive image
246:CompTox Dashboard
1776:
1769:Antihemorrhagics
1677:
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1253:Calcium alginate
1009:
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991:Antihemorrhagics
978:Antihemorrhagics
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620:(3): F183–F187.
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131:-ethylethanamine
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1664:
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1608:
1581:for topical use
1554:
1536:
1486:
1462:Fluorometholone
1438:corticosteroids
1429:for topical use
1421:
1414:Vasoprotectives
1411:
1381:
1376:
1326:Tranexamic acid
1296:
1232:
1166:
1160:
1083:Turoctocog alfa
1079:Susoctocog alfa
1075:Moroctocog alfa
1045:
1038:
1033:
1024:
993:
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975:
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789:"Show lekforms"
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694:
656:
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526:hyaluronic acid
502:angioprotective
498:
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442:antihemorrhagic
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417:(what is this?)
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506:thrombopoiesis
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485:
477:dobesilic acid
462:prostaglandins
452:and promoting
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1764:Hydroquinones
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1682:bioflavonoids
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1472:Dexamethasone
1470:
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1467:Fluocortolone
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1457:Betamethasone
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1226:Rafutrombopag
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1221:Lusutrombopag
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1179:Carbazochrome
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1152:combinations:
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786:
785:"Search TKFS"
782:
778:
774:
772:
768:
767:"Искать ТКФС"
764:
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752:
749:
738:on 2012-10-10
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279:ECHA InfoCard
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262:DTXSID4045559
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45:Clinical data
43:
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1720:
1680:
1651:
1613:
1573:
1564:Antivaricose
1541:
1491:
1482:Fluocinonide
1452:Prednisolone
1436:
1355:C1-inhibitor
1337:
1313:
1211:Avatrombopag
1198:
1194:Fostamatinib
1188:
1151:
1145:Catridecacog
1136:I/Fibrinogen
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1116:Eptacog alfa
1108:
1101:Nonacog alfa
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1030:Menadione (K
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533:
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519:The precise
518:
510:Prostacyclin
499:
490:
481:diethylamine
470:
466:vasodilation
458:biosynthesis
437:
433:
432:
421:
415:
128:
1729:Tribenoside
1696:Monoxerutin
1627:Polidocanol
1579:heparinoids
1550:Tribenoside
1370:Ulinastatin
1315:amino acids
1272:Fibrin glue
1263:Epinephrine
1216:Eltrombopag
1206:Romiplostim
1131:II/Thrombin
1044:Coagulation
996:coagulation
915:: 167–172.
659:Experientia
487:Indications
450:capillaries
446:endothelium
438:ethamsylate
342: g·mol
285:100.018.265
111:Identifiers
60:Other names
51:Trade names
1753:Categories
1734:Etamsylate
1706:Troxerutin
1532:Pramocaine
1527:Oxetacaine
1512:Benzocaine
1507:Tetracaine
1267:adrenalone
1189:Etamsylate
1184:Concizumab
1174:Batroxobin
1109:extrinsic:
1054:intrinsic:
742:2013-08-10
543:References
434:Etamsylate
347:3D model (
335:Molar mass
215:24YL531VOH
186:ChemSpider
141:CAS Number
120:IUPAC name
21:Etamsylate
1711:Hidrosmin
1517:Dibucaine
1502:Lidocaine
1366:unsorted
1345:Aprotinin
1013:Vitamin K
937:207594182
777:Etamzilat
759:Этамзилат
150:2624-44-4
73:Drugs.com
1691:Rutoside
1575:heparins
1522:Procaine
1360:Camostat
1287:Thrombin
1258:Collagen
1167:systemic
1005:Systemic
929:29555505
858:15613569
779:, flags
761:, флаги
687:36393605
644:11320045
595:15613570
514:adhesion
454:platelet
440:) is an
424:(verify)
87:ATC code
1701:Diosmin
1599:Heparin
1566:therapy
1339:serpins
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479:and
473:salt
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