Knowledge (XXG)

Evogliptin

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and is approved for use in South Korea and Russia. In a meta-analysis involving data from 6 randomized controlled trials (887 patients), Dutta et. al. demonstrated the good glycaemic efficacy and safety of this medicine as compared to other DPP4 inhibitors like sitagliptin and linagliptin.
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InChI=1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1
366: 1856: 1836: 1810: 1190: 592: 1727: 817: 547:"Efficacy and Safety of Novel Dipeptidyl-Peptidase-4 Inhibitor Evogliptin in the Management of Type 2 Diabetes Mellitus: A Meta-Analysis" 1803: 1584: 527: 413: 386: 1287: 429: 1042: 767: 106: 1851: 729: 771: 192: 1744: 1420: 834: 252: 1382: 1248: 781: 1689: 1589: 1579: 1694: 1664: 1609: 1569: 1033: 869: 1674: 1654: 1599: 1649: 1644: 1783: 1732: 1704: 1679: 1659: 1624: 1604: 1594: 1574: 1564: 1487: 822: 59: 1639: 1634: 1709: 1669: 1629: 1492: 241: 1841: 1699: 1684: 1619: 1614: 1846: 1559: 268: 1779: 624: 127: 66: 1311: 1081: 1331: 745: 483: 437: 1260: 906: 793: 679: 578: 475: 425: 181: 41: 1787: 136: 1547: 763: 725: 568: 558: 467: 289: 201: 720: 702: 272: 1738: 1482: 1147: 1076: 828: 777: 684: 674: 654: 632: 573: 546: 1830: 1528: 1507: 1502: 1497: 1477: 1472: 1467: 1462: 1457: 1351: 1107: 1066: 954: 949: 939: 934: 740: 161: 487: 1771: 1361: 1356: 1336: 1238: 1228: 1223: 1112: 1086: 1054: 1014: 992: 987: 982: 969: 959: 944: 924: 910: 636: 86: 81: 1346: 1341: 1326: 1321: 1316: 1272: 1266: 1233: 1218: 1208: 1203: 1198: 1176: 1171: 1166: 1157: 1142: 1127: 1117: 1096: 1071: 1019: 977: 929: 919: 735: 502:"Dong-A ST's DPP4 inhibitor, SUGANON, got approved for type 2 diabetes in Korea" 433: 1523: 1410: 1400: 1395: 1390: 1301: 1296: 1137: 1122: 1091: 896: 471: 328: 172: 563: 1533: 1448: 1438: 1405: 1256: 1213: 1132: 891: 878: 582: 479: 20: 545:
Dutta D, Bhattacharya S, Krishnamurthy A, Sharma LK, Sharma M (Nov 2020).
1433: 1428: 886: 528:"Evodine (evogliptin) film-coated tablets. Full prescribing information" 650: 628: 147: 28: 1002: 232: 458:
McCormack PL (November 2015). "Evogliptin: First Global Approval".
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or "gliptin" class of drugs. It was developed by the
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You can help Knowledge (XXG) by 14: 1837:Dipeptidyl peptidase-4 inhibitors 1770: 312: 306: 300: 399:Key:LCDDAGSJHKEABN-MLGOLLRUSA-N 318: 294: 118:)-4--3-{methyl}-2-piperazinone 1: 1421:Alpha-glucosidase inhibitors 1383:Aldose reductase inhibitors 1873: 1765: 1249:GLP1 poly-agonist peptides 284:Chemical and physical data 1695:Sitagliptin/ertugliflozin 1690:Sitagliptin/dapagliflozin 1610:Glimepiride/rosiglitazone 1590:Empagliflozin/linagliptin 1580:Dapagliflozin/saxagliptin 1555: 1108:Glibenclamide (glyburide) 864: 853: 661: 644: 551:Indian J Endocrinol Metab 472:10.1007/s40265-015-0496-5 382: 362: 102: 26: 1782:article relating to the 1675:Pioglitazone/sitagliptin 1665:Pioglitazone/glimepiride 1655:Phenformin/sulfonylureas 1600:Gemigliptin/rosuvastatin 1570:Cagrilintide/semaglutide 564:10.4103/ijem.IJEM_418_20 1784:gastrointestinal system 1705:Sitagliptin/simvastatin 1680:Rosiglitazone/metformin 1660:Pioglitazone/alogliptin 1650:Metformin/teneligliptin 1645:Metformin/sulfonylureas 1625:Metformin/ertugliflozin 1595:Empagliflozin/metformin 1575:Dapagliflozin/metformin 1565:Canagliflozin/metformin 1191:GLP-1 receptor agonists 436:pharmaceutical company 1710:Vildagliptin/metformin 1670:Pioglitazone/metformin 1700:Sitagliptin/metformin 1685:Saxagliptin/metformin 1640:Metformin/repaglinide 1635:Metformin/gemigliptin 1615:Linagliptin/metformin 1852:Tert-butyl compounds 1630:Metformin/evogliptin 1560:Alogliptin/metformin 870:Insulin sensitizers 625:diabetes medication 23: 1749:Never to phase III 1620:Metformin/acarbose 970:Dual PPAR agonists 839:Never to phase III 746:Ultralente insulin 1799: 1798: 1763: 1762: 1759: 1758: 1722: 1721: 1718: 1717: 1542: 1541: 1370: 1369: 1282: 1281: 1185: 1184: 1028: 1027: 849: 848: 812: 811: 756:ultra-long-acting 680:Insulin glulisine 426:antidiabetic drug 407: 406: 353:Interactive image 253:CompTox Dashboard 16:Chemical compound 1864: 1820: 1813: 1806: 1774: 1767: 1553: 1449:SGLT2 inhibitors 1379: 1288:DPP-4 inhibitors 1269:(GLP-1/GIP/GCGR) 1245: 1051: 1039: 875: 866: 855: 764:Insulin degludec 726:Insulin glargine 663: 646: 617: 610: 603: 594: 587: 586: 576: 566: 542: 536: 535: 524: 518: 517: 515: 513: 508:on June 30, 2022 498: 492: 491: 455: 355: 335: 320: 314: 308: 302: 296: 276: 275: 261: 259: 244: 224: 204: 184: 164: 154: 153: 139: 89: 31: 24: 22: 1872: 1871: 1867: 1866: 1865: 1863: 1862: 1861: 1827: 1826: 1825: 1824: 1764: 1755: 1754: 1739:Clinical trials 1714: 1538: 1512: 1443: 1415: 1366: 1278: 1243: 1181: 1152: 1046: 1024: 997: 964: 909:/"glitazones" ( 901: 860: 845: 844: 829:Clinical trials 808: 787: 768:+insulin aspart 750: 721:Insulin detemir 707: 703:Regular insulin 689: 657: 655:insulin analogs 640: 633:insulin analogs 621: 591: 590: 544: 543: 539: 526: 525: 521: 511: 509: 500: 499: 495: 457: 456: 452: 447: 403: 400: 395: 390: 389: 378: 375: 370: 369: 358: 333: 323: 317: 311: 305: 299: 279: 255: 247: 227: 207: 187: 167: 150: 142: 122: 119: 110: 109: 93: 61: 17: 12: 11: 5: 1870: 1868: 1860: 1859: 1854: 1849: 1844: 1839: 1829: 1828: 1823: 1822: 1815: 1808: 1800: 1797: 1796: 1775: 1761: 1760: 1757: 1756: 1753: 1752: 1751: 1750: 1747: 1736: 1730: 1724: 1723: 1720: 1719: 1716: 1715: 1713: 1712: 1707: 1702: 1697: 1692: 1687: 1682: 1677: 1672: 1667: 1662: 1657: 1652: 1647: 1642: 1637: 1632: 1627: 1622: 1617: 1612: 1607: 1602: 1597: 1592: 1587: 1582: 1577: 1572: 1567: 1562: 1556: 1550: 1544: 1543: 1540: 1539: 1537: 1536: 1531: 1526: 1520: 1518: 1514: 1513: 1511: 1510: 1505: 1500: 1495: 1490: 1485: 1483:Luseogliflozin 1480: 1475: 1470: 1465: 1460: 1454: 1452: 1445: 1444: 1442: 1441: 1436: 1431: 1425: 1423: 1417: 1416: 1414: 1413: 1408: 1403: 1398: 1393: 1387: 1385: 1376: 1372: 1371: 1368: 1367: 1365: 1364: 1359: 1354: 1349: 1344: 1339: 1334: 1329: 1324: 1319: 1314: 1309: 1304: 1299: 1293: 1291: 1284: 1283: 1280: 1279: 1277: 1276: 1270: 1264: 1253: 1251: 1242: 1241: 1236: 1231: 1226: 1221: 1216: 1211: 1206: 1201: 1195: 1193: 1187: 1186: 1183: 1182: 1180: 1179: 1174: 1169: 1163: 1161: 1154: 1153: 1151: 1150: 1148:Glyclopyramide 1145: 1140: 1135: 1130: 1125: 1120: 1115: 1110: 1104:2nd generation 1100: 1099: 1094: 1089: 1084: 1079: 1077:Chlorpropamide 1074: 1069: 1063:1st generation 1059: 1057: 1048: 1044: 1036: 1030: 1029: 1026: 1025: 1023: 1022: 1017: 1011: 1009: 999: 998: 996: 995: 990: 985: 980: 974: 972: 966: 965: 963: 962: 957: 952: 947: 942: 937: 932: 927: 922: 916: 914: 903: 902: 900: 899: 894: 889: 883: 881: 872: 862: 861: 858: 851: 850: 847: 846: 843: 842: 841: 840: 837: 826: 820: 814: 813: 810: 809: 807: 806: 803: 799: 797: 789: 788: 786: 785: 778:Insulin icodec 775: 760: 758: 752: 751: 749: 748: 743: 738: 733: 723: 717: 715: 709: 708: 706: 705: 699: 697: 691: 690: 688: 687: 685:Insulin lispro 682: 677: 675:Insulin aspart 671: 669: 659: 658: 649: 642: 641: 622: 620: 619: 612: 605: 597: 589: 588: 557:(5): 434–445. 537: 519: 493: 466:(17): 2045–9. 449: 448: 446: 443: 416:; trade names 405: 404: 402: 401: 398: 396: 393: 385: 384: 383: 380: 379: 377: 376: 373: 365: 364: 363: 360: 359: 357: 356: 348: 346: 338: 337: 331: 325: 324: 321: 315: 309: 303: 297: 292: 286: 285: 281: 280: 278: 277: 269:DTXSID00153545 264: 262: 249: 248: 246: 245: 237: 235: 229: 228: 226: 225: 217: 215: 209: 208: 206: 205: 197: 195: 189: 188: 186: 185: 177: 175: 169: 168: 166: 165: 157: 155: 144: 143: 141: 140: 132: 130: 124: 123: 121: 120: 113: 105: 104: 103: 100: 99: 95: 94: 92: 91: 78: 76: 70: 69: 64: 62:administration 56: 55: 52: 48: 47: 44: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 1869: 1858: 1855: 1853: 1850: 1848: 1845: 1843: 1840: 1838: 1835: 1834: 1832: 1821: 1816: 1814: 1809: 1807: 1802: 1801: 1795: 1793: 1789: 1785: 1781: 1776: 1773: 1769: 1748: 1746: 1743: 1742: 1740: 1737: 1734: 1731: 1729: 1726: 1725: 1711: 1708: 1706: 1703: 1701: 1698: 1696: 1693: 1691: 1688: 1686: 1683: 1681: 1678: 1676: 1673: 1671: 1668: 1666: 1663: 1661: 1658: 1656: 1653: 1651: 1648: 1646: 1643: 1641: 1638: 1636: 1633: 1631: 1628: 1626: 1623: 1621: 1618: 1616: 1613: 1611: 1608: 1606: 1603: 1601: 1598: 1596: 1593: 1591: 1588: 1586: 1583: 1581: 1578: 1576: 1573: 1571: 1568: 1566: 1563: 1561: 1558: 1557: 1554: 1551: 1549: 1545: 1535: 1532: 1530: 1529:Bromocriptine 1527: 1525: 1522: 1521: 1519: 1515: 1509: 1508:Velagliflozin 1506: 1504: 1503:Tofogliflozin 1501: 1499: 1498:Sotagliflozin 1496: 1494: 1491: 1489: 1488:Remogliflozin 1486: 1484: 1481: 1479: 1478:Ipragliflozin 1476: 1474: 1473:Ertugliflozin 1471: 1469: 1468:Empagliflozin 1466: 1464: 1463:Dapagliflozin 1461: 1459: 1458:Canagliflozin 1456: 1455: 1453: 1451:/"gliflozins" 1450: 1446: 1440: 1437: 1435: 1432: 1430: 1427: 1426: 1424: 1422: 1418: 1412: 1409: 1407: 1404: 1402: 1399: 1397: 1394: 1392: 1389: 1388: 1386: 1384: 1380: 1377: 1373: 1363: 1360: 1358: 1355: 1353: 1352:Teneligliptin 1350: 1348: 1345: 1343: 1340: 1338: 1335: 1333: 1330: 1328: 1325: 1323: 1320: 1318: 1315: 1313: 1310: 1308: 1305: 1303: 1300: 1298: 1295: 1294: 1292: 1289: 1285: 1274: 1271: 1268: 1265: 1262: 1258: 1255: 1254: 1252: 1250: 1246: 1240: 1237: 1235: 1232: 1230: 1227: 1225: 1222: 1220: 1217: 1215: 1212: 1210: 1207: 1205: 1202: 1200: 1197: 1196: 1194: 1192: 1188: 1178: 1175: 1173: 1170: 1168: 1165: 1164: 1162: 1159: 1155: 1149: 1146: 1144: 1141: 1139: 1136: 1134: 1131: 1129: 1126: 1124: 1121: 1119: 1116: 1114: 1111: 1109: 1105: 1102: 1101: 1098: 1095: 1093: 1090: 1088: 1085: 1083: 1080: 1078: 1075: 1073: 1070: 1068: 1067:Acetohexamide 1064: 1061: 1060: 1058: 1056: 1055:Sulfonylureas 1052: 1049: 1047: 1040: 1037: 1035: 1034:Secretagogues 1031: 1021: 1018: 1016: 1013: 1012: 1010: 1008: 1004: 1000: 994: 991: 989: 986: 984: 981: 979: 976: 975: 973: 971: 967: 961: 958: 956: 955:Rosiglitazone 953: 951: 950:Rivoglitazone 948: 946: 943: 941: 940:Netoglitazone 938: 936: 935:Lobeglitazone 933: 931: 928: 926: 923: 921: 918: 917: 915: 912: 908: 904: 898: 895: 893: 890: 888: 885: 884: 882: 880: 876: 873: 871: 867: 863: 856: 852: 838: 836: 833: 832: 830: 827: 824: 821: 819: 816: 815: 804: 801: 800: 798: 796: 795: 790: 783: 779: 776: 773: 769: 765: 762: 761: 759: 757: 753: 747: 744: 742: 741:Lente insulin 739: 737: 734: 731: 730:+lixisenatide 727: 724: 722: 719: 718: 716: 714: 710: 704: 701: 700: 698: 696: 692: 686: 683: 681: 678: 676: 673: 672: 670: 668: 664: 660: 656: 652: 647: 643: 638: 634: 630: 626: 618: 613: 611: 606: 604: 599: 598: 595: 584: 580: 575: 570: 565: 560: 556: 552: 548: 541: 538: 534:(in Russian). 533: 529: 523: 520: 507: 503: 497: 494: 489: 485: 481: 477: 473: 469: 465: 461: 454: 451: 444: 442: 439: 435: 431: 427: 423: 419: 415: 411: 397: 392: 388: 381: 372: 368: 361: 354: 350: 349: 347: 344: 339: 332: 330: 326: 293: 291: 287: 282: 274: 270: 266: 265: 263: 254: 250: 243: 242:ChEMBL1779710 239: 238: 236: 234: 230: 223: 219: 218: 216: 214: 210: 203: 199: 198: 196: 194: 190: 183: 179: 178: 176: 174: 170: 163: 159: 158: 156: 149: 145: 138: 134: 133: 131: 129: 125: 117: 112: 108: 101: 96: 88: 83: 80: 79: 77: 75: 71: 68: 65: 63: 57: 53: 49: 45: 43: 39: 36:Clinical data 34: 30: 25: 1842:Fluoroarenes 1792:expanding it 1777: 1548:Combinations 1493:Sergliflozin 1362:Vildagliptin 1357:Trelagliptin 1337:Omarigliptin 1312:Garvagliptin 1306: 1239:Taspoglutide 1229:Orforglipron 1224:Lixisenatide 1158:Meglitinides 1113:Glibornuride 1103: 1087:Metahexamide 1082:Glycyclamide 1062: 1015:Cagrilintide 1005:analogs and 993:Tesaglitazar 988:Saroglitazar 983:Muraglitazar 960:Troglitazone 945:Pioglitazone 925:Darglitazone 859:Non-insulins 792: 782:+semaglutide 772:+liraglutide 755: 712: 695:short-acting 694: 666: 554: 550: 540: 531: 522: 510:. Retrieved 506:the original 496: 463: 459: 453: 434:South Korean 421: 417: 409: 408: 137:1222102-29-5 115: 1847:Piperazines 1735:from market 1347:Sitagliptin 1342:Saxagliptin 1332:Melogliptin 1327:Linagliptin 1322:Gosogliptin 1317:Gemigliptin 1290:/"gliptins" 1275:(GLP-1/GIP) 1273:Tirzepatide 1267:Retatrutide 1234:Semaglutide 1219:Liraglutide 1209:Dulaglutide 1204:Danuglipron 1199:Albiglutide 1177:Repaglinide 1172:Nateglinide 1167:Mitiglinide 1160:/"glinides" 1143:Glisoxepide 1128:Glimepiride 1118:Glicaramide 1097:Tolbutamide 1072:Carbutamide 1020:Pramlintide 978:Aleglitazar 930:Englitazone 920:Ciglitazone 825:from market 736:NPH insulin 713:long-acting 667:fast-acting 512:February 1, 336: g·mol 98:Identifiers 51:Other names 42:Trade names 1831:Categories 1524:Benfluorex 1411:Zenarestat 1401:Ranirestat 1396:Fidarestat 1391:Epalrestat 1307:Evogliptin 1302:Anagliptin 1297:Alogliptin 1138:Gliquidone 1123:Gliclazide 1092:Tolazamide 897:Phenformin 879:Biguanides 445:References 410:Evogliptin 341:3D model ( 329:Molar mass 202:09118300L7 173:ChemSpider 128:CAS Number 107:IUPAC name 21:Evogliptin 1745:Phase III 1733:Withdrawn 1534:Imeglimin 1439:Voglibose 1406:Tolrestat 1257:Mazdutide 1214:Exenatide 1133:Glipizide 892:Metformin 835:Phase III 823:Withdrawn 794:inhalable 438:Dong-A ST 60:Routes of 1434:Miglitol 1429:Acarbose 887:Buformin 651:Insulins 629:insulins 583:33489850 488:46450821 480:26541763 424:) is an 182:26339341 162:25022354 74:ATC code 67:By mouth 1259:(GLP-1/ 805:Afrezza 802:Exubera 574:7810058 428:in the 422:Evodine 418:Suganon 334:401.430 290:Formula 148:PubChem 90:) 84: ( 82:A10BH07 54:DA-1229 46:Suganon 1728:WHO-EM 1007:DACRAs 1003:Amylin 818:WHO-EM 581:  571:  486:  478:  367:SMILES 233:ChEMBL 222:D11023 1786:is a 1778:This 1517:Other 1375:Other 623:Oral 484:S2CID 460:Drugs 387:InChI 343:JSmol 1788:stub 1780:drug 1261:GCGR 911:PPAR 907:TZDs 631:and 579:PMID 514:2017 476:PMID 213:KEGG 193:UNII 1045:ATP 637:A10 569:PMC 559:doi 468:doi 414:INN 258:EPA 152:CID 87:WHO 1833:: 1741:: 1106:: 1065:: 831:: 770:, 627:, 577:. 567:. 555:24 553:. 549:. 530:. 482:. 474:. 464:75 462:. 420:, 304:26 298:19 114:(3 1819:e 1812:t 1805:v 1794:. 1263:) 1043:K 913:) 784:) 780:( 774:) 766:( 732:) 728:( 653:/ 639:) 616:e 609:t 602:v 585:. 561:: 516:. 490:. 470:: 412:( 345:) 322:3 319:O 316:3 313:N 310:3 307:F 301:H 295:C 260:) 256:( 116:R

Index


Trade names
Routes of
administration

By mouth
ATC code
A10BH07
WHO
IUPAC name
CAS Number
1222102-29-5
PubChem
25022354
ChemSpider
26339341
UNII
09118300L7
KEGG
D11023
ChEMBL
ChEMBL1779710
CompTox Dashboard
DTXSID00153545
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
INN

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