341:
318:
215:
240:
347:
246:
3381:
1321:
transcription factors to regulate their transcriptional activity, including MyoD, C/EBP, Reptin, p53, MEF2D, MEF2C and MTA1. Furthermore, G9A/GLP are able to methylate non-histone proteins to regulate complexes which recruit DNA methyltransferases to gene promoters to repress transcription via the methylation of
1320:
analyses, the function of many of these modifications remain unknown. Nevertheless, increasing evidence suggests methylation of non-histone proteins may influence protein stability, protein-protein interactions and regulate cellular signalling pathways. For example, G9A/GLP can methylate a number of
50:
1325:. Therefore, G9A and/or GLP have wide-ranging roles in development, establishing and maintaining cell identity, cell cycle regulation, and cellular responses to environmental stimuli, which are dependent on their non-histone protein methyltransferase activity.
1308:, which is involved in protein-protein interactions. The ankyrin repeat domain also contains H3K9me1 and H3K9me2 binding sites. Therefore, the G9A/GLP complex can both methylate histone tails and bind to mono- and di-methylated H3K9 to recruit molecules, such as
1288:. When transiently over expressed, G9A and GLP form homo- and heterodimers via their SET domain. However, endogenously both enzymes function exclusively as a heteromeric complex. Although G9A and GLP can exert their methyltransferase activities independently
1315:
In addition to their role as histone lysine methyltransferases (HMTs), several studies have shown that G9A/GLP are also able to methylate a wide range of non-histone proteins. However, as most of the reported methylation sites have been derived from
1300:
are severely reduced and are equivalent to H3K9me2 levels in G9a and Glp double knockout mice. Therefore, it is thought that G9A cannot compensate for the loss of GLP methyltransferase activity
1312:, to the chromatin. H3K9me2 is a reversible modification and can be removed by a wide range of histone lysine demethylases (KDMs) including KDM1, KDM3, KDM4 and KDM7 family members.
2711:
354:
253:
2912:
2569:"Lysine methylation of the NF-ÎşB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-ÎşB signaling"
2866:
2767:
2930:
2836:
3031:
886:
867:
176:
2520:"Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling"
2810:
3041:
2757:
2704:
1417:
1399:
47:
2363:"Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing"
3401:
2995:
3067:
2787:
2783:
1154:
340:
3100:
1161:
317:
2951:
2697:
147:, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1, EHMT1-IT1, KLEFS1
1623:"Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9"
3026:
2907:
1386:
1365:
1460:"Loss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndrome"
3016:
3011:
2935:
2815:
3256:
1382:
239:
214:
2792:
2752:
3371:
2257:"A core chromatin remodeling factor instructs global chromatin signaling through multivalent reading of nucleosome codes"
1438:
1361:
3021:
2861:
156:
3036:
1285:
2035:"Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation"
353:
252:
3241:
346:
245:
3357:
3344:
3331:
3318:
3305:
3292:
3279:
3055:
2970:
2880:
2846:
2762:
2733:
1284:
activity. The SET domain primarily functions to establish and maintain H3K9 mono and di-methylation, a marker of
3251:
3205:
3148:
2899:
2724:
931:
164:
3153:
1304:, and vice versa. Another important functional domain, which G9A and GLP both share, is a region containing
912:
2148:"Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation"
2956:
1334:
3174:
3093:
2856:
2306:"MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a"
1309:
1241:
3246:
2851:
2374:
2317:
2211:
2046:
1874:
1764:"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease"
228:
143:
3210:
2820:
2469:
Thienpont B, Aronsen JM, Robinson EL, Okkenhaug H, Loche E, Ferrini A, et al. (January 2017).
2422:"Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription"
1133:
1129:
1125:
1104:
1094:
1090:
1086:
1078:
1054:
1050:
1046:
1025:
1021:
1011:
1007:
1003:
995:
1571:"Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase"
3143:
1843:
1744:
188:
2689:
1977:
Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A (September 2008).
1458:
Kleefstra T, Brunner HG, Amiel J, Oudakker AR, Nillesen WM, Magee A, et al. (August 2006).
1137:
1082:
1058:
999:
3406:
2922:
2737:
2669:
2647:
2598:
2549:
2518:
Harman JL, Dobnikar L, Chappell J, Stokell BG, Dalby A, Foote K, et al. (November 2019).
2500:
2451:
2402:
2343:
2286:
2237:
2177:
2128:
2074:
2010:
1956:
1902:
1835:
1793:
1736:
1701:
1652:
1600:
1551:
1489:
1317:
1281:
136:
40:
2095:
Huang J, Dorsey J, Chuikov S, PĂ©rez-Burgos L, Zhang X, Jenuwein T, et al. (March 2010).
3189:
3184:
3158:
3086:
2637:
2629:
2588:
2580:
2539:
2531:
2490:
2482:
2441:
2433:
2392:
2382:
2333:
2325:
2276:
2268:
2227:
2219:
2167:
2159:
2118:
2108:
2064:
2054:
2000:
1990:
1979:"G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta"
1946:
1938:
1892:
1882:
1863:"Novel Function of Lysine Methyltransferase G9a in the Regulation of Sox2 Protein Stability"
1827:
1783:
1775:
1728:
1691:
1683:
1642:
1634:
1590:
1582:
1541:
1533:
1479:
1471:
433:
364:
308:
263:
1670:
Zhang T, Termanis A, Ă–zkan B, Bao XX, Culley J, de Lima Alves F, et al. (April 2016).
184:
3236:
3220:
3133:
2974:
1245:
408:
2471:"The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy"
2420:
Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR (July 2012).
2378:
2321:
2215:
2050:
1878:
1340:
Dysregulation of EHMT1 has been implicated in inflammatory and cardiovascular diseases.
3385:
3274:
3215:
2642:
2617:
2593:
2568:
2544:
2519:
2495:
2470:
2446:
2421:
2397:
2362:
2338:
2305:
2281:
2256:
2232:
2199:
2172:
2147:
2123:
2096:
2069:
2034:
2005:
1978:
1951:
1926:
1897:
1862:
1788:
1763:
1696:
1671:
1647:
1622:
1595:
1570:
1546:
1521:
1484:
1459:
1305:
1253:
2618:"The role of smooth muscle cells in plaque stability: Therapeutic targeting potential"
2361:
Leung DC, Dong KB, Maksakova IA, Goyal P, Appanah R, Lee S, et al. (April 2011).
2304:
Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, et al. (November 2011).
1621:
Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, et al. (April 2005).
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
705:
700:
695:
690:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
3395:
3179:
3138:
2884:
2678:
2567:
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, et al. (January 2011).
611:
1847:
1816:"Non-histone protein methylation as a regulator of cellular signalling and function"
1748:
168:
3128:
2802:
2198:
Ow JR, Palanichamy Kala M, Rao VK, Choi MH, Bharathy N, Taneja R (September 2016).
426:
205:
2272:
2033:
Ling BM, Bharathy N, Chung TK, Kok WK, Li S, Tan YH, et al. (January 2012).
1942:
1887:
1687:
1586:
192:
3352:
3287:
3123:
2720:
1422:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1404:
National Center for
Biotechnology Information, U.S. National Library of Medicine
3380:
2535:
2367:
Proceedings of the
National Academy of Sciences of the United States of America
2039:
Proceedings of the
National Academy of Sciences of the United States of America
509:
1273:
1261:
1257:
1249:
325:
222:
172:
1672:"G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells"
3326:
3300:
2980:
2387:
2113:
2059:
831:
569:
447:
392:
379:
291:
278:
180:
2651:
2602:
2553:
2504:
2455:
2406:
2347:
2290:
2241:
2181:
2132:
2078:
2014:
1995:
1960:
1906:
1839:
1797:
1740:
1705:
1656:
1604:
1555:
1493:
1569:
Xiong Y, Li F, Babault N, Dong A, Zeng H, Wu H, et al. (March 2017).
1201:
1196:
2163:
1927:"Negative regulation of hypoxic responses via induced Reptin methylation"
1861:
Lee JY, Lee SH, Heo SH, Kim KS, Kim C, Kim DK, et al. (2015-10-22).
1815:
1322:
1185:
976:
957:
1925:
Lee JS, Kim Y, Kim IS, Kim B, Choi HJ, Lee JM, et al. (July 2010).
1779:
1638:
1537:
3059:
2683:
2673:
2329:
2146:
Choi J, Jang H, Kim H, Lee JH, Kim ST, Cho EJ, Youn HD (January 2014).
1297:
1225:
943:
898:
2633:
2437:
2223:
1732:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
3339:
3109:
2889:
2841:
2486:
1169:
853:
2584:
1831:
1719:
Delcuve GP, Rastegar M, Davie JR (May 2009). "Epigenetic control".
1475:
3313:
1277:
816:
812:
1229:
160:
3082:
2693:
1439:"Entrez Gene: Euchromatic histone-lysine N-methyltransferase 1"
2097:"G9a and Glp methylate lysine 373 in the tumor suppressor p53"
2668:
Overview of all the structural information available in the
2200:"G9a inhibits MEF2C activity to control sarcomere assembly"
3078:
1522:"H3K9 methyltransferase G9a and the related molecule GLP"
732:
negative regulation of transcription by RNA polymerase II
1272:
G9A-like protein (GLP) shares an evolutionary conserved
416:
802:
regulation of signal transduction by p53 class mediator
1762:
Cloos PA, Christensen J, Agger K, Helin K (May 2008).
3369:
1260:. Isoforms two and three have missing or incomplete
581:
660:
histone methyltransferase activity (H3-K27 specific)
3265:
3229:
3198:
3167:
3116:
3054:
3004:
2988:
2969:
2944:
2921:
2898:
2879:
2829:
2801:
2776:
2745:
2732:
1118:
1077:
1039:
994:
777:
negative regulation of transcription, DNA-templated
635:
histone methyltransferase activity (H3-K9 specific)
2682:(Histone-lysine N-methyltransferase EHMT1) at the
2524:Arteriosclerosis, Thrombosis, and Vascular Biology
1378:
1376:
1374:
1357:
1355:
1353:
1333:Defects in this gene are a cause of chromosome 9q
797:positive regulation of cold-induced thermogenesis
363:
262:
2913:3-methyl-2-oxobutanoate hydroxymethyltransferase
1616:
1614:
1214:Euchromatic histone-lysine N-methyltransferase 1
16:Protein-coding gene in the species Homo sapiens
1809:
1807:
1515:
1513:
1511:
1509:
1507:
1505:
1503:
1383:GRCm38: Ensembl release 89: ENSMUSG00000036893
3094:
2867:Cyclopropane-fatty-acyl-phospholipid synthase
2705:
2090:
2088:
1972:
1970:
8:
2768:Phosphatidylethanolamine N-methyltransferase
2028:
2026:
2024:
2931:Phosphoribosylglycinamide formyltransferase
2837:Phosphatidyl ethanolamine methyltransferase
1920:
1918:
1916:
1362:GRCh38: Ensembl release 89: ENSG00000181090
665:protein-lysine N-methyltransferase activity
650:histone-lysine N-methyltransferase activity
3101:
3087:
3079:
3032:3-hydroxymethylcephem carbamoyltransferase
2985:
2895:
2742:
2712:
2698:
2690:
2193:
2191:
1074:
991:
827:
782:negative regulation of G0 to G1 transition
607:
404:
303:
200:
58:
2641:
2592:
2543:
2494:
2445:
2396:
2386:
2337:
2280:
2255:Nair SS, Li DQ, Kumar R (February 2013).
2231:
2171:
2122:
2112:
2068:
2058:
2004:
1994:
1950:
1896:
1886:
1787:
1695:
1646:
1594:
1545:
1483:
2616:Harman JL, Jørgensen HF (October 2019).
1433:
1431:
3376:
1349:
1337:(9q-syndrome or Kleefstra syndrome-1).
1292:, if either G9a or Glp are knocked out
1228:that in humans is encoded by the EHMT1
3042:N-acetylornithine carbamoyltransferase
2811:Betaine-homocysteine methyltransferase
2758:Phenylethanolamine N-methyltransferase
1820:Nature Reviews. Molecular Cell Biology
1252:, the canonical isoform one has eight
18:
2475:The Journal of Clinical Investigation
1520:Shinkai Y, Tachibana M (April 2011).
368:
329:
324:
267:
226:
221:
7:
2996:methylmalonyl-CoA carboxytransferase
3068:Arginine:glycine amidinotransferase
2788:Acetylserotonin O-methyltransferase
2784:5-hydroxyindole-O-methyltransferase
2101:The Journal of Biological Chemistry
1983:The Journal of Biological Chemistry
792:regulation of embryonic development
1464:American Journal of Human Genetics
1115:
1036:
967:
948:
922:
903:
877:
858:
586:
504:
442:
421:
14:
1814:Biggar KK, Li SS (January 2015).
3379:
2952:Glutamate formimidoyltransferase
2426:Journal of Cellular Biochemistry
352:
345:
339:
316:
251:
244:
238:
213:
3027:Putrescine carbamoyltransferase
2908:Serine hydroxymethyltransferase
2622:British Journal of Pharmacology
737:peptidyl-lysine monomethylation
645:C2H2 zinc finger domain binding
3017:Ornithine carbamoyltransferase
3012:Aspartate carbamoyltransferase
2936:Inosine monophosphate synthase
2816:Homocysteine methyltransferase
1721:Journal of Cellular Physiology
1575:Journal of Medicinal Chemistry
1335:subtelomeric deletion syndrome
570:More reference expression data
478:right hemisphere of cerebellum
1:
2793:Catechol-O-methyl transferase
2753:Histamine N-methyltransferase
762:peptidyl-lysine dimethylation
337:
236:
3022:Oxamate carbamoyltransferase
2862:Thiopurine methyltransferase
2273:10.1016/j.molcel.2012.12.016
1943:10.1016/j.molcel.2010.06.008
1888:10.1371/journal.pone.0141118
1688:10.1016/j.celrep.2016.03.007
1587:10.1021/acs.jmedchem.6b01645
3402:Genes on human chromosome 9
3037:Lysine carbamoyltransferase
2723:: one carbon transferases (
1244:to produce three predicted
3423:
2536:10.1161/ATVBAHA.119.312765
1286:faculative heterochromatin
1264:SET domains respectively.
767:histone lysine methylation
742:histone H3-K27 methylation
625:methyltransferase activity
528:superior cervical ganglion
3257:Michaelis–Menten kinetics
2847:Histone methyltransferase
2763:Amine N-methyltransferase
1418:"Mouse PubMed Reference:"
1400:"Human PubMed Reference:"
1200:
1195:
1191:
1184:
1168:
1155:Chr 9: 137.62 – 137.87 Mb
1149:
1122:
1101:
1070:
1043:
1018:
987:
974:
970:
955:
951:
942:
929:
925:
910:
906:
897:
884:
880:
865:
861:
852:
837:
830:
826:
810:
757:histone H3-K9 methylation
610:
606:
594:
589:
580:
567:
516:
507:
454:
445:
415:
407:
403:
386:
373:
336:
315:
306:
302:
285:
272:
235:
212:
203:
199:
154:
151:
141:
134:
129:
66:
61:
44:
39:
34:
30:
26:
21:
3149:Diffusion-limited enzyme
2900:Hydroxymethyltransferase
524:Rostral migratory stream
2388:10.1073/pnas.1014660108
2114:10.1074/jbc.M109.062588
2060:10.1073/pnas.1111628109
1768:Genes & Development
1627:Genes & Development
1526:Genes & Development
1240:EHMT1 messenger RNA is
1162:Chr 2: 24.79 – 24.92 Mb
2957:Aminomethyltransferase
2152:Nucleic Acids Research
1996:10.1074/jbc.M802132200
1310:DNA methyltransferases
787:chromatin organization
3242:Eadie–Hofstee diagram
3175:Allosteric regulation
2857:DNA methyltransferase
2310:Nature Communications
1329:Clinical significance
1248:. Starting from the
1242:alternatively spliced
722:response to fungicide
544:mandibular prominence
3252:Lineweaver–Burk plot
2852:Thymidylate synthase
630:transferase activity
540:maxillary prominence
331:Chromosome 2 (mouse)
229:Chromosome 9 (human)
62:List of PDB id codes
35:Available structures
2821:Methionine synthase
2379:2011PNAS..108.5718L
2322:2011NatCo...2..533C
2216:2016NatSR...634163O
2051:2012PNAS..109..841L
1879:2015PLoSO..1041118L
1780:10.1101/gad.1652908
1639:10.1101/gad.1284005
1538:10.1101/gad.2027411
1296:, global levels of
1256:, a pre-SET, and a
772:histone methylation
556:ganglionic eminence
3211:Enzyme superfamily
3144:Enzyme promiscuity
2330:10.1038/ncomms1549
2204:Scientific Reports
2164:10.1093/nar/gkt873
1280:, responsible for
932:ENSMUSG00000036893
727:embryo development
715:Biological process
684:Cellular component
618:Molecular function
3367:
3366:
3076:
3075:
3050:
3049:
2965:
2964:
2923:Formyltransferase
2875:
2874:
2634:10.1111/bph.14779
2628:(19): 3741–3753.
2573:Nature Immunology
2530:(11): 2289–2302.
2438:10.1002/jcb.24114
2224:10.1038/srep34163
1733:10.1002/jcp.21678
1318:mass spectrometry
1282:methyltransferase
1211:
1210:
1207:
1206:
1180:
1179:
1145:
1144:
1112:
1111:
1066:
1065:
1033:
1032:
983:
982:
964:
963:
938:
937:
919:
918:
893:
892:
874:
873:
822:
821:
655:metal ion binding
602:
601:
598:
597:
576:
575:
563:
562:
501:
500:
399:
398:
298:
297:
193:EHMT1 - orthologs
125:
124:
121:
120:
45:Ortholog search:
3414:
3384:
3383:
3375:
3247:Hanes–Woolf plot
3190:Enzyme activator
3185:Enzyme inhibitor
3159:Enzyme catalysis
3103:
3096:
3089:
3080:
2986:
2896:
2743:
2714:
2707:
2700:
2691:
2656:
2655:
2645:
2613:
2607:
2606:
2596:
2564:
2558:
2557:
2547:
2515:
2509:
2508:
2498:
2487:10.1172/JCI88353
2466:
2460:
2459:
2449:
2417:
2411:
2410:
2400:
2390:
2358:
2352:
2351:
2341:
2301:
2295:
2294:
2284:
2252:
2246:
2245:
2235:
2195:
2186:
2185:
2175:
2143:
2137:
2136:
2126:
2116:
2092:
2083:
2082:
2072:
2062:
2030:
2019:
2018:
2008:
1998:
1989:(39): 26357–63.
1974:
1965:
1964:
1954:
1922:
1911:
1910:
1900:
1890:
1873:(10): e0141118.
1858:
1852:
1851:
1811:
1802:
1801:
1791:
1759:
1753:
1752:
1716:
1710:
1709:
1699:
1667:
1661:
1660:
1650:
1618:
1609:
1608:
1598:
1581:(5): 1876–1891.
1566:
1560:
1559:
1549:
1517:
1498:
1497:
1487:
1455:
1449:
1448:
1446:
1445:
1435:
1426:
1425:
1414:
1408:
1407:
1396:
1390:
1380:
1369:
1359:
1246:protein isoforms
1218:G9a-like protein
1216:, also known as
1193:
1192:
1164:
1157:
1140:
1116:
1107:
1075:
1071:RefSeq (protein)
1061:
1037:
1028:
992:
968:
949:
923:
904:
878:
859:
828:
640:zinc ion binding
608:
587:
572:
512:
510:Top expressed in
505:
450:
448:Top expressed in
443:
422:
405:
395:
382:
371:
356:
349:
343:
332:
320:
304:
294:
281:
270:
255:
248:
242:
231:
217:
201:
195:
146:
139:
116:
59:
53:
32:
31:
19:
3422:
3421:
3417:
3416:
3415:
3413:
3412:
3411:
3392:
3391:
3390:
3378:
3370:
3368:
3363:
3275:Oxidoreductases
3261:
3237:Enzyme kinetics
3225:
3221:List of enzymes
3194:
3163:
3134:Catalytic triad
3112:
3107:
3077:
3072:
3046:
3000:
2978:
2961:
2940:
2917:
2888:
2871:
2825:
2797:
2772:
2728:
2718:
2665:
2660:
2659:
2615:
2614:
2610:
2585:10.1038/ni.1968
2566:
2565:
2561:
2517:
2516:
2512:
2468:
2467:
2463:
2419:
2418:
2414:
2373:(14): 5718–23.
2360:
2359:
2355:
2303:
2302:
2298:
2254:
2253:
2249:
2197:
2196:
2189:
2145:
2144:
2140:
2107:(13): 9636–41.
2094:
2093:
2086:
2032:
2031:
2022:
1976:
1975:
1968:
1924:
1923:
1914:
1860:
1859:
1855:
1832:10.1038/nrm3915
1813:
1812:
1805:
1761:
1760:
1756:
1718:
1717:
1713:
1669:
1668:
1664:
1620:
1619:
1612:
1568:
1567:
1563:
1519:
1518:
1501:
1457:
1456:
1452:
1443:
1441:
1437:
1436:
1429:
1416:
1415:
1411:
1398:
1397:
1393:
1381:
1372:
1360:
1351:
1346:
1331:
1306:ankryin repeats
1270:
1254:ankyrin repeats
1238:
1202:View/Edit Mouse
1197:View/Edit Human
1160:
1153:
1150:Location (UCSC)
1136:
1132:
1128:
1124:
1103:
1097:
1093:
1089:
1085:
1081:
1057:
1053:
1049:
1045:
1024:
1020:
1014:
1010:
1006:
1002:
998:
913:ENSG00000181090
806:
747:DNA methylation
710:
679:
670:protein binding
568:
559:
554:
550:
546:
542:
538:
534:
530:
526:
522:
508:
497:
492:
488:
484:
480:
476:
472:
468:
464:
460:
446:
390:
377:
369:
359:
358:
357:
350:
330:
307:Gene location (
289:
276:
268:
258:
257:
256:
249:
227:
204:Gene location (
155:
142:
135:
68:
46:
17:
12:
11:
5:
3420:
3418:
3410:
3409:
3404:
3394:
3393:
3389:
3388:
3365:
3364:
3362:
3361:
3348:
3335:
3322:
3309:
3296:
3283:
3269:
3267:
3263:
3262:
3260:
3259:
3254:
3249:
3244:
3239:
3233:
3231:
3227:
3226:
3224:
3223:
3218:
3213:
3208:
3202:
3200:
3199:Classification
3196:
3195:
3193:
3192:
3187:
3182:
3177:
3171:
3169:
3165:
3164:
3162:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3120:
3118:
3114:
3113:
3108:
3106:
3105:
3098:
3091:
3083:
3074:
3073:
3071:
3070:
3064:
3062:
3052:
3051:
3048:
3047:
3045:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3008:
3006:
3002:
3001:
2999:
2998:
2992:
2990:
2983:
2967:
2966:
2963:
2962:
2960:
2959:
2954:
2948:
2946:
2942:
2941:
2939:
2938:
2933:
2927:
2925:
2919:
2918:
2916:
2915:
2910:
2904:
2902:
2893:
2877:
2876:
2873:
2872:
2870:
2869:
2864:
2859:
2854:
2849:
2844:
2839:
2833:
2831:
2827:
2826:
2824:
2823:
2818:
2813:
2807:
2805:
2799:
2798:
2796:
2795:
2790:
2780:
2778:
2774:
2773:
2771:
2770:
2765:
2760:
2755:
2749:
2747:
2740:
2730:
2729:
2719:
2717:
2716:
2709:
2702:
2694:
2688:
2687:
2664:
2663:External links
2661:
2658:
2657:
2608:
2559:
2510:
2481:(1): 335–348.
2461:
2432:(7): 2406–14.
2412:
2353:
2296:
2261:Molecular Cell
2247:
2187:
2138:
2084:
2020:
1966:
1931:Molecular Cell
1912:
1853:
1803:
1774:(9): 1115–40.
1754:
1711:
1662:
1610:
1561:
1499:
1476:10.1086/505693
1450:
1427:
1409:
1391:
1370:
1348:
1347:
1345:
1342:
1330:
1327:
1269:
1266:
1237:
1234:
1209:
1208:
1205:
1204:
1199:
1189:
1188:
1182:
1181:
1178:
1177:
1175:
1173:
1166:
1165:
1158:
1151:
1147:
1146:
1143:
1142:
1120:
1119:
1113:
1110:
1109:
1099:
1098:
1072:
1068:
1067:
1064:
1063:
1041:
1040:
1034:
1031:
1030:
1016:
1015:
989:
985:
984:
981:
980:
972:
971:
965:
962:
961:
953:
952:
946:
940:
939:
936:
935:
927:
926:
920:
917:
916:
908:
907:
901:
895:
894:
891:
890:
882:
881:
875:
872:
871:
863:
862:
856:
850:
849:
844:
839:
835:
834:
824:
823:
820:
819:
808:
807:
805:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
718:
716:
712:
711:
709:
708:
703:
698:
693:
687:
685:
681:
680:
678:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
621:
619:
615:
614:
604:
603:
600:
599:
596:
595:
592:
591:
584:
578:
577:
574:
573:
565:
564:
561:
560:
558:
557:
553:
549:
548:tail of embryo
545:
541:
537:
533:
529:
525:
521:
517:
514:
513:
502:
499:
498:
496:
495:
491:
487:
483:
479:
475:
474:body of uterus
471:
467:
463:
459:
455:
452:
451:
439:
438:
430:
419:
413:
412:
409:RNA expression
401:
400:
397:
396:
388:
384:
383:
375:
372:
367:
361:
360:
351:
344:
338:
334:
333:
328:
322:
321:
313:
312:
300:
299:
296:
295:
287:
283:
282:
274:
271:
266:
260:
259:
250:
243:
237:
233:
232:
225:
219:
218:
210:
209:
197:
196:
153:
149:
148:
140:
132:
131:
127:
126:
123:
122:
119:
118:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3419:
3408:
3405:
3403:
3400:
3399:
3397:
3387:
3382:
3377:
3373:
3359:
3355:
3354:
3349:
3346:
3342:
3341:
3336:
3333:
3329:
3328:
3323:
3320:
3316:
3315:
3310:
3307:
3303:
3302:
3297:
3294:
3290:
3289:
3284:
3281:
3277:
3276:
3271:
3270:
3268:
3264:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3235:
3234:
3232:
3228:
3222:
3219:
3217:
3216:Enzyme family
3214:
3212:
3209:
3207:
3204:
3203:
3201:
3197:
3191:
3188:
3186:
3183:
3181:
3180:Cooperativity
3178:
3176:
3173:
3172:
3170:
3166:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3139:Oxyanion hole
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3121:
3119:
3115:
3111:
3104:
3099:
3097:
3092:
3090:
3085:
3084:
3081:
3069:
3066:
3065:
3063:
3061:
3057:
3053:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3009:
3007:
3003:
2997:
2994:
2993:
2991:
2987:
2984:
2982:
2976:
2972:
2968:
2958:
2955:
2953:
2950:
2949:
2947:
2943:
2937:
2934:
2932:
2929:
2928:
2926:
2924:
2920:
2914:
2911:
2909:
2906:
2905:
2903:
2901:
2897:
2894:
2892:- and Related
2891:
2886:
2885:Hydroxymethyl
2882:
2878:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2838:
2835:
2834:
2832:
2828:
2822:
2819:
2817:
2814:
2812:
2809:
2808:
2806:
2804:
2800:
2794:
2791:
2789:
2785:
2782:
2781:
2779:
2775:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2750:
2748:
2744:
2741:
2739:
2735:
2731:
2726:
2722:
2715:
2710:
2708:
2703:
2701:
2696:
2695:
2692:
2685:
2681:
2680:
2675:
2671:
2667:
2666:
2662:
2653:
2649:
2644:
2639:
2635:
2631:
2627:
2623:
2619:
2612:
2609:
2604:
2600:
2595:
2590:
2586:
2582:
2578:
2574:
2570:
2563:
2560:
2555:
2551:
2546:
2541:
2537:
2533:
2529:
2525:
2521:
2514:
2511:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2465:
2462:
2457:
2453:
2448:
2443:
2439:
2435:
2431:
2427:
2423:
2416:
2413:
2408:
2404:
2399:
2394:
2389:
2384:
2380:
2376:
2372:
2368:
2364:
2357:
2354:
2349:
2345:
2340:
2335:
2331:
2327:
2323:
2319:
2315:
2311:
2307:
2300:
2297:
2292:
2288:
2283:
2278:
2274:
2270:
2267:(4): 704–18.
2266:
2262:
2258:
2251:
2248:
2243:
2239:
2234:
2229:
2225:
2221:
2217:
2213:
2209:
2205:
2201:
2194:
2192:
2188:
2183:
2179:
2174:
2169:
2165:
2161:
2158:(1): 224–34.
2157:
2153:
2149:
2142:
2139:
2134:
2130:
2125:
2120:
2115:
2110:
2106:
2102:
2098:
2091:
2089:
2085:
2080:
2076:
2071:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2029:
2027:
2025:
2021:
2016:
2012:
2007:
2002:
1997:
1992:
1988:
1984:
1980:
1973:
1971:
1967:
1962:
1958:
1953:
1948:
1944:
1940:
1936:
1932:
1928:
1921:
1919:
1917:
1913:
1908:
1904:
1899:
1894:
1889:
1884:
1880:
1876:
1872:
1868:
1864:
1857:
1854:
1849:
1845:
1841:
1837:
1833:
1829:
1825:
1821:
1817:
1810:
1808:
1804:
1799:
1795:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1758:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1727:(2): 243–50.
1726:
1722:
1715:
1712:
1707:
1703:
1698:
1693:
1689:
1685:
1681:
1677:
1673:
1666:
1663:
1658:
1654:
1649:
1644:
1640:
1636:
1633:(7): 815–26.
1632:
1628:
1624:
1617:
1615:
1611:
1606:
1602:
1597:
1592:
1588:
1584:
1580:
1576:
1572:
1565:
1562:
1557:
1553:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1516:
1514:
1512:
1510:
1508:
1506:
1504:
1500:
1495:
1491:
1486:
1481:
1477:
1473:
1469:
1465:
1461:
1454:
1451:
1440:
1434:
1432:
1428:
1423:
1419:
1413:
1410:
1405:
1401:
1395:
1392:
1388:
1384:
1379:
1377:
1375:
1371:
1367:
1363:
1358:
1356:
1354:
1350:
1343:
1341:
1338:
1336:
1328:
1326:
1324:
1319:
1313:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1267:
1265:
1263:
1259:
1255:
1251:
1247:
1243:
1235:
1233:
1231:
1227:
1223:
1219:
1215:
1203:
1198:
1194:
1190:
1187:
1183:
1176:
1174:
1171:
1167:
1163:
1159:
1156:
1152:
1148:
1141:
1139:
1135:
1131:
1127:
1121:
1117:
1114:
1108:
1106:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1073:
1069:
1062:
1060:
1056:
1052:
1048:
1042:
1038:
1035:
1029:
1027:
1023:
1017:
1013:
1009:
1005:
1001:
997:
993:
990:
988:RefSeq (mRNA)
986:
979:
978:
973:
969:
966:
960:
959:
954:
950:
947:
945:
941:
934:
933:
928:
924:
921:
915:
914:
909:
905:
902:
900:
896:
889:
888:
883:
879:
876:
870:
869:
864:
860:
857:
855:
851:
848:
845:
843:
840:
836:
833:
829:
825:
818:
814:
809:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
719:
717:
714:
713:
707:
704:
702:
699:
697:
694:
692:
689:
688:
686:
683:
682:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
622:
620:
617:
616:
613:
612:Gene ontology
609:
605:
593:
588:
585:
583:
579:
571:
566:
555:
551:
547:
543:
539:
535:
532:otolith organ
531:
527:
523:
519:
518:
515:
511:
506:
503:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
456:
453:
449:
444:
441:
440:
437:
435:
431:
429:
428:
424:
423:
420:
418:
414:
410:
406:
402:
394:
389:
385:
381:
376:
366:
362:
355:
348:
342:
335:
327:
323:
319:
314:
310:
305:
301:
293:
288:
284:
280:
275:
265:
261:
254:
247:
241:
234:
230:
224:
220:
216:
211:
207:
202:
198:
194:
190:
186:
182:
178:
174:
170:
166:
162:
158:
150:
145:
138:
133:
128:
117:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3353:Translocases
3350:
3337:
3324:
3311:
3298:
3288:Transferases
3285:
3272:
3129:Binding site
2803:Homocysteine
2677:
2625:
2621:
2611:
2579:(1): 29–36.
2576:
2572:
2562:
2527:
2523:
2513:
2478:
2474:
2464:
2429:
2425:
2415:
2370:
2366:
2356:
2313:
2309:
2299:
2264:
2260:
2250:
2210:(1): 34163.
2207:
2203:
2155:
2151:
2141:
2104:
2100:
2045:(3): 841–6.
2042:
2038:
1986:
1982:
1937:(1): 71–85.
1934:
1930:
1870:
1866:
1856:
1823:
1819:
1771:
1767:
1757:
1724:
1720:
1714:
1682:(1): 77–85.
1679:
1676:Cell Reports
1675:
1665:
1630:
1626:
1578:
1574:
1564:
1532:(8): 781–8.
1529:
1525:
1470:(2): 370–7.
1467:
1463:
1453:
1442:. Retrieved
1421:
1412:
1403:
1394:
1339:
1332:
1314:
1301:
1293:
1289:
1271:
1239:
1221:
1217:
1213:
1212:
1134:NP_001103157
1130:NP_001103156
1126:NP_001012536
1123:
1105:NP_001341541
1102:
1095:NP_001341540
1091:NP_001341192
1087:NP_001341188
1079:NP_001138999
1055:NM_001109687
1051:NM_001109686
1047:NM_001012518
1044:
1026:NM_001354612
1022:NM_001354611
1019:
1012:NM_001354263
1008:NM_001354259
1004:NM_001039765
996:NM_001145527
975:
956:
930:
911:
885:
866:
846:
841:
706:nuclear body
466:right testis
432:
425:
290:137,870,016
277:137,618,992
152:External IDs
67:
3124:Active site
2721:Transferase
1826:(1): 5–17.
1323:CpG islands
1258:SET domains
752:methylation
691:nucleoplasm
675:p53 binding
494:right ovary
486:granulocyte
482:skin of leg
462:left testis
458:sural nerve
391:24,919,614
378:24,789,928
370:2|2 A3
130:Identifiers
3396:Categories
3327:Isomerases
3301:Hydrolases
3168:Regulation
1444:2012-03-04
1389:, May 2017
1368:, May 2017
1344:References
1274:SET domain
1262:C-terminal
1250:N-terminus
696:chromosome
490:ectocervix
470:left ovary
436:(ortholog)
173:HomoloGene
3206:EC number
3005:Carbamoyl
2981:Carbamoyl
1236:Structure
1138:NP_766133
1083:NP_079033
1059:NM_172545
1000:NM_024757
832:Orthologs
181:GeneCards
3407:EC 2.1.1
3230:Kinetics
3154:Cofactor
3117:Activity
2652:31254285
2603:21131967
2554:31434493
2505:27893464
2456:22389001
2407:21427230
2348:22086334
2291:23352453
2242:27667720
2182:24078251
2133:20118233
2079:22215600
2015:18647749
1961:20603076
1907:26492085
1867:PLOS ONE
1848:12558106
1840:25491103
1798:18451103
1749:39355478
1741:19127539
1706:27052169
1657:15774718
1605:28135087
1556:21498567
1494:16826528
1385:–
1364:–
1290:in vitro
1268:Function
1224:), is a
1186:Wikidata
811:Sources:
3386:Biology
3340:Ligases
3110:Enzymes
3060:Amidine
2989:Carboxy
2975:Carboxy
2738:Methyl-
2684:PDBe-KB
2674:UniProt
2643:6780045
2594:3074206
2545:6818986
2496:5199699
2447:3350606
2398:3078371
2375:Bibcode
2339:3286832
2318:Bibcode
2316:: 533.
2282:3582764
2233:5036183
2212:Bibcode
2173:3874188
2124:2843213
2070:3271886
2047:Bibcode
2006:3258912
1952:4651011
1898:4619656
1875:Bibcode
1789:2732404
1697:4826439
1648:1074319
1596:5352984
1547:3078703
1485:1559478
1387:Ensembl
1366:Ensembl
1302:in vivo
1298:H3K9me2
1294:in vivo
1226:protein
944:UniProt
899:Ensembl
838:Species
817:QuickGO
701:nucleus
536:utricle
411:pattern
169:1924933
137:Aliases
3372:Portal
3314:Lyases
2890:Formyl
2842:DNMT3B
2679:Q9H9B1
2650:
2640:
2601:
2591:
2552:
2542:
2503:
2493:
2454:
2444:
2405:
2395:
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2336:
2289:
2279:
2240:
2230:
2180:
2170:
2131:
2121:
2077:
2067:
2013:
2003:
1959:
1949:
1905:
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1838:
1796:
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1739:
1704:
1694:
1655:
1645:
1603:
1593:
1554:
1544:
1492:
1482:
1172:search
1170:PubMed
977:Q5DW34
958:Q9H9B1
854:Entrez
582:BioGPS
269:9q34.3
161:607001
3266:Types
3056:2.1.4
2971:2.1.3
2945:Other
2881:2.1.2
2830:Other
2734:2.1.1
1844:S2CID
1745:S2CID
1276:with
887:77683
868:79813
847:Mouse
842:Human
813:Amigo
434:Mouse
427:Human
374:Start
309:Mouse
273:Start
206:Human
185:EHMT1
177:11698
144:EHMT1
22:EHMT1
3358:list
3351:EC7
3345:list
3338:EC6
3332:list
3325:EC5
3319:list
3312:EC4
3306:list
3299:EC3
3293:list
3286:EC2
3280:list
3273:EC1
2979:and
2727:2.1)
2672:for
2648:PMID
2599:PMID
2550:PMID
2501:PMID
2452:PMID
2403:PMID
2344:PMID
2287:PMID
2238:PMID
2178:PMID
2129:PMID
2075:PMID
2011:PMID
1957:PMID
1903:PMID
1836:PMID
1794:PMID
1737:PMID
1702:PMID
1653:PMID
1601:PMID
1552:PMID
1490:PMID
1230:gene
552:foot
520:hand
417:Bgee
365:Band
326:Chr.
264:Band
223:Chr.
157:OMIM
114:4I51
110:3SWC
106:3SW9
102:3MO5
98:3MO2
94:3MO0
90:3HNA
86:3FPD
82:3B95
78:3B7B
74:2RFI
70:2IGQ
51:RCSB
48:PDBe
2670:PDB
2638:PMC
2630:doi
2626:176
2589:PMC
2581:doi
2540:PMC
2532:doi
2491:PMC
2483:doi
2479:127
2442:PMC
2434:doi
2430:113
2393:PMC
2383:doi
2371:108
2334:PMC
2326:doi
2277:PMC
2269:doi
2228:PMC
2220:doi
2168:PMC
2160:doi
2119:PMC
2109:doi
2105:285
2065:PMC
2055:doi
2043:109
2001:PMC
1991:doi
1987:283
1947:PMC
1939:doi
1893:PMC
1883:doi
1828:doi
1784:PMC
1776:doi
1729:doi
1725:219
1692:PMC
1684:doi
1643:PMC
1635:doi
1591:PMC
1583:doi
1542:PMC
1534:doi
1480:PMC
1472:doi
1278:G9A
1222:GLP
590:n/a
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286:End
189:OMA
165:MGI
41:PDB
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