332:
309:
206:
231:
590:
583:
338:
237:
31:
3695:
3638:
1368:
complex class III region. This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there is only a single gene. The protein encoded by this gene is thought to be involved in intracellular protein-protein interaction. There are three alternatively spliced transcript variants of this gene but only two are fully described.
1419:) in the nucleus accumbens, and therefore opposes ΔFosB's function as well as increases in its expression. G9a and ΔFosB share many of the same gene targets. In addition to its role in the nucleus accumbens, G9a play a critical role in the development and the maintenance of neuropathic pain. Following peripheral nerve injury, G9a regulates the expression of +600 genes in the
1261:
1367:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair. These genes are all within the human major histocompatibility
2729:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
2640:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
2066:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
57:
1489:
ENSG00000224143, ENSG00000206376, ENSG00000204371, ENSG00000227333, ENSG00000232045, ENSG00000236759 GRCh38: Ensembl release 89: ENSG00000238134, ENSG00000224143, ENSG00000206376, ENSG00000204371, ENSG00000227333, ENSG00000232045,
2641:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1773:
1747:
2071:, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2419:
Shi Y, Sawada J, Sui G, el Affar B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex".
2812:"Autorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86"
1614:"Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3"
3376:
2773:
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".
1279:
345:
244:
2331:
Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (May 2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells".
3396:
878:
859:
167:
1777:
1751:
2732:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
2294:
Brown SE, Campbell RD, Sanderson CM (December 2001). "Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions".
1545:
1451:, and its dysregulation can be associated with cancer. Abnormal EHMT2 expression is found both in haematological malignancies, as for example
3674:
2378:"G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis"
1527:
54:
3723:
331:
3589:
3061:
2918:
2688:"Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1"
3694:
3451:
1203:
1196:
308:
1690:
1423:. This transcriptomic change reprograms the sensory neurons to a hyperexcitable state leading to mechanical pain hypersensitivity.
1297:
1656:
3514:
3381:
3594:
3584:
1514:
1493:
1510:
230:
205:
3217:
1488:
3446:
3431:
3419:
3359:
2597:"In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases"
147:
2376:
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y (July 2002).
3044:
1432:
344:
243:
1565:"The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats"
3479:
3014:
337:
236:
3667:
3544:
3474:
3426:
3386:
3266:
3120:
1322:
2243:"Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B"
3227:
2544:"CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription"
2124:"Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation"
949:
155:
3529:
3519:
3497:
2911:
2595:
Collins RE, Tachibana M, Tamaru H, Smith KM, Jia D, Zhang X, Selker EU, Shinkai Y, Cheng X (February 2005).
930:
926:
916:
912:
908:
904:
900:
3549:
3369:
3336:
3261:
3256:
3049:
2853:
Estève PO, Chin HG, Smallwood A, Feehery GR, Gangisetty O, Karpf AR, Carey MF, Pradhan S (November 2006).
2466:"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse"
1408:
1403:
and is suppressed by ΔFosB. G9a exerts opposite effects to that of ΔFosB on drug-related behavior (e.g.,
3616:
3611:
3539:
3524:
3436:
3034:
1384:
3660:
3534:
3391:
3202:
3079:
3056:
2998:
2935:
2855:"Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication"
2650:
2555:
2428:
2340:
2254:
2135:
2080:
2022:
219:
134:
2896:
2509:"Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes"
3458:
3341:
3291:
3286:
3276:
3271:
3222:
2988:
2179:
Haebe, Joshua R.; Bergin, Christopher J.; Sandouka, Tamara; Benoit, Yannick D. (13 November 2021).
1962:"G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition"
1420:
1404:
1391:(NAcc); reduced G9a expression in the NAcc plays a central role in mediating the development of an
1179:
1175:
1165:
1153:
1149:
1134:
1122:
1118:
1084:
1080:
1059:
1055:
1051:
1047:
1043:
1039:
1029:
1025:
1013:
1945:
3641:
3604:
3579:
3569:
3364:
3301:
3281:
2983:
2904:
2798:
2674:
2452:
2364:
2319:
2104:
1886:
1718:
179:
1161:
1157:
1130:
1126:
1092:
1088:
1021:
1017:
3599:
3441:
2968:
2884:
2841:
2790:
2761:
2717:
2666:
2628:
2583:
2530:
2495:
2444:
2407:
2356:
2311:
2282:
2218:
2200:
2161:
2096:
2048:
1991:
1935:
1878:
1837:
1706:
1686:
1635:
1594:
1460:
1388:
1352:
589:
127:
47:
1344:
3132:
3029:
3009:
2874:
2866:
2831:
2823:
2782:
2751:
2743:
2707:
2699:
2658:
2618:
2608:
2573:
2563:
2520:
2485:
2477:
2436:
2397:
2389:
2348:
2303:
2272:
2262:
2208:
2192:
2151:
2143:
2088:
2038:
2030:
1981:
1973:
1925:
1917:
1868:
1827:
1819:
1696:
1678:
1625:
1584:
1576:
1372:
424:
355:
299:
254:
582:
175:
3623:
3507:
3232:
2978:
2973:
2464:
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003).
2011:"G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons"
1730:
1416:
399:
2654:
2559:
2432:
2344:
2258:
2139:
2084:
2026:
3489:
3021:
2958:
2879:
2854:
2836:
2811:
2756:
2731:
2712:
2703:
2687:
2623:
2596:
2213:
2180:
2156:
2123:
2043:
2010:
1986:
1961:
1930:
1905:
1832:
1807:
1701:
1589:
1564:
1448:
1356:
138:, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2
30:
2578:
2543:
2490:
2465:
2402:
2377:
2277:
2242:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
717:
712:
707:
702:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
3717:
3502:
2927:
1823:
618:
2802:
2368:
1890:
159:
2678:
2456:
2323:
2108:
417:
196:
2525:
2508:
183:
2963:
2068:
1550:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1532:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1464:
2548:
Proceedings of the
National Academy of Sciences of the United States of America
2247:
Proceedings of the
National Academy of Sciences of the United States of America
2196:
1682:
500:
3574:
3414:
3251:
2810:
Reeves M, Murphy J, Greaves R, Fairley J, Brehm A, Sinclair J (October 2006).
2307:
2181:"Emerging role of G9a in cancer stemness and promises as a therapeutic target"
1675:
Role of the Brain's Reward
Circuitry in Depression: Transcriptional Mechanisms
1336:
316:
213:
163:
2686:
Duan Z, Zarebski A, Montoya-Durango D, Grimes HL, Horwitz M (December 2005).
2204:
3317:
2943:
2931:
2568:
2352:
2267:
2147:
1392:
1380:
823:
560:
438:
383:
370:
282:
269:
171:
2888:
2845:
2794:
2765:
2721:
2670:
2632:
2613:
2587:
2534:
2499:
2448:
2411:
2360:
2315:
2222:
2165:
2100:
2052:
1995:
1939:
1882:
1841:
1710:
1639:
1630:
1613:
2286:
1598:
1243:
1238:
3111:
2827:
1456:
1452:
1436:
1412:
1396:
1227:
994:
975:
2870:
2662:
2440:
2092:
1375:, another histone-lysine N-methyltransferase, catalyze the synthesis of
2747:
2481:
2393:
1400:
1376:
1348:
961:
890:
2034:
1580:
104:
100:
96:
92:
88:
84:
80:
76:
3173:
1657:"Entrez Gene: EHMT2 euchromatic histone-lysine N-methyltransferase 2"
1340:
1325:
1211:
845:
2786:
1977:
1921:
1873:
1856:
1355:
and H3K27me2). The presence of H3K9me1/2 is usually associated with
3183:
3178:
3168:
3163:
3158:
3152:
3145:
3138:
3106:
3091:
2507:
Roopra A, Qazi R, Schoenike B, Daley TJ, Morrison JF (June 2004).
808:
804:
3101:
3096:
3085:
2730:
Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006).
1946:
Figure 4: Epigenetic basis of drug regulation of gene expression
1332:
598:
151:
3656:
2900:
1439:
and the prostate tissue associated homeodomain protein NKX3.1.
3652:
3126:
1254:
1612:
Tachibana M, Sugimoto K, Fukushima T, Shinkai Y (July 2001).
1774:"Histone-lysine N-methyltransferase, H3 lysine-9 specific 5"
1748:"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"
1801:
1799:
1797:
1795:
1857:"Psychiatric disorders: a feat of epigenetic engineering"
1447:
EHMT2 is known to drive process such as self-renewal and
744:
negative regulation of transcription by RNA polymerase II
1906:"Transcriptional and epigenetic mechanisms of addiction"
407:
1275:
794:
regulation of signal transduction by p53 class mediator
2241:
Spies T, Bresnahan M, Strominger JL (November 1989).
1335:. G9a deposits the mono- and di-methylated states of
572:
3377:
Community reinforcement approach and family training
672:
histone methyltransferase activity (H3-K27 specific)
3562:
3488:
3467:
3405:
3350:
3329:
3316:
3241:
3210:
3201:
3070:
2997:
2951:
2942:
1270:
may be too technical for most readers to understand
1148:
1111:
1073:
1012:
642:
histone methyltransferase activity (H3-K9 specific)
543:
dentate gyrus of hippocampal formation granule cell
1506:
1504:
1502:
1484:
1482:
1480:
354:
253:
1383:mark. G9a is an important control mechanism for
1311:Euchromatic histone-lysine N-methyltransferase 2
3703:: Human euchromatic histone methyltransferase 2
1955:
1953:
1776:. HIstome: The Histone Infobase. Archived from
1750:. HIstome: The Histone Infobase. Archived from
16:Protein-coding gene in the species Homo sapiens
1668:
1666:
1511:GRCm38: Ensembl release 89: ENSMUSG00000013787
3668:
2912:
1742:
1740:
8:
677:protein-lysine N-methyltransferase activity
662:histone-lysine N-methyltransferase activity
3675:
3661:
3653:
3326:
3207:
2948:
2919:
2905:
2897:
1411:– the development of additional tree-like
1145:
1009:
895:
819:
784:negative regulation of G0 to G1 transition
614:
395:
294:
191:
65:
2878:
2835:
2755:
2711:
2622:
2612:
2577:
2567:
2524:
2489:
2401:
2276:
2266:
2212:
2155:
2042:
1985:
1929:
1872:
1831:
1808:"Epigenetic mechanisms of drug addiction"
1700:
1629:
1588:
1298:Learn how and when to remove this message
1282:, without removing the technical details.
1651:
1649:
3690:
1904:Robison AJ, Nestler EJ (October 2011).
1476:
1726:
1716:
20:
1563:Milner CM, Campbell RD (March 1993).
1280:make it understandable to non-experts
359:
320:
315:
258:
217:
212:
7:
3590:Discrimination against drug addicts
2601:The Journal of Biological Chemistry
1618:The Journal of Biological Chemistry
647:promoter-specific chromatin binding
3452:Tobacco cessation clinics in India
2704:10.1128/MCB.25.23.10338-10351.2005
2542:Nishio H, Walsh MJ (August 2004).
2122:Dutta A, et al. (June 2016).
1677:. Vol. 124. pp. 151–70.
1108:
1070:
985:
966:
940:
869:
850:
577:
495:
433:
412:
14:
1407:) and synaptic remodeling (e.g.,
1328:that in humans is encoded by the
3693:
3637:
3636:
3515:Low-threshold treatment programs
3382:Motivational enhancement therapy
1824:10.1016/j.neuropharm.2013.04.004
1259:
588:
581:
343:
336:
330:
307:
242:
235:
229:
204:
29:
3595:Dopamine dysregulation syndrome
3585:Category:Vaccines against drugs
739:cellular response to starvation
657:C2H2 zinc finger domain binding
2692:Molecular and Cellular Biology
599:More reference expression data
561:More reference expression data
469:right hemisphere of cerebellum
1:
3218:Adverse childhood experiences
759:peptidyl-lysine dimethylation
734:regulation of DNA replication
328:
227:
3447:Nicotine replacement therapy
3432:Intensive outpatient program
3420:Residential treatment center
3360:Cognitive behavioral therapy
2526:10.1016/j.molcel.2004.05.026
2067:Sikorski RS, Vandenhaute J,
1910:Nature Reviews. Neuroscience
1861:Nature Reviews. Neuroscience
1395:. G9a opposes increases in
3724:Genes on human chromosome 6
3045:Internet addiction disorder
1855:Whalley K (December 2014).
1806:Nestler EJ (January 2014).
1467:, head and neck tumours.
3740:
3480:List of twelve-step groups
2197:10.1038/s41389-021-00370-7
1683:10.1016/bs.irn.2015.07.003
1673:Nestler EJ (August 2015).
774:histone H3-K27 methylation
764:histone lysine methylation
632:methyltransferase activity
3688:
3632:
3545:Supervised injection site
3475:Addiction recovery groups
3427:Heroin-assisted treatment
3387:Motivational interviewing
2308:10.1007/s00335-001-3029-3
1960:Laumet, Geoffroy (2015).
1546:"Mouse PubMed Reference:"
1528:"Human PubMed Reference:"
1351:) and lysine residue 27 (
1323:histone methyltransferase
1242:
1237:
1233:
1226:
1210:
1191:
1172:
1115:
1104:
1077:
1036:
1005:
992:
988:
973:
969:
960:
947:
943:
924:
898:
889:
876:
872:
857:
853:
844:
829:
822:
818:
802:
779:histone H3-K9 methylation
617:
613:
596:
580:
571:
558:
507:
498:
485:anterior cingulate cortex
445:
436:
406:
398:
394:
377:
364:
327:
306:
297:
293:
276:
263:
226:
203:
194:
190:
145:
142:
132:
125:
120:
73:
68:
51:
46:
41:
37:
28:
23:
3228:Psychological dependence
3062:Digital media addictions
1431:EHMT2 has been shown to
1204:Chr 17: 35.12 – 35.13 Mb
3530:Needle exchange program
3520:Managed alcohol program
3498:Category:Harm reduction
2859:Genes & Development
2569:10.1073/pnas.0401343101
2382:Genes & Development
2353:10.1126/science.1069861
2268:10.1073/pnas.86.22.8955
2148:10.1126/science.aad9512
1569:The Biochemical Journal
3550:Tobacco harm reduction
3370:Contingency management
3337:Alcohol detoxification
3050:Internet sex addiction
2614:10.1074/jbc.M410483200
2009:Liang, Lingli (2016).
1631:10.1074/jbc.M101914200
1409:dendritic arborization
1197:Chr 6: 31.88 – 31.9 Mb
789:chromatin organization
539:superior frontal gyrus
361:17 B1|17 18.45 cM
3612:Motivational salience
3540:Stimulant maintenance
3525:Moderation Management
3437:Methadone maintenance
1385:epigenetic regulation
547:primary visual cortex
322:Chromosome 17 (mouse)
3535:Responsible drug use
3392:Motivational therapy
3057:Video game addiction
2828:10.1128/JVI.01297-06
2775:Nature Biotechnology
637:transferase activity
220:Chromosome 6 (human)
69:List of PDB id codes
42:Available structures
3459:Twelve-step program
3342:Drug detoxification
3223:Physical dependence
2871:10.1101/gad.1463706
2816:Journal of Virology
2663:10.1038/nature04209
2655:2005Natur.437.1173R
2560:2004PNAS..10111257N
2441:10.1038/nature01550
2433:2003Natur.422..735S
2345:2002Sci...296.1132O
2259:1989PNAS...86.8955S
2140:2016Sci...352.1576D
2093:10.1038/nature04209
2085:2005Natur.437.1173R
2027:2016NatSR...637704L
1966:Nature Neuroscience
1421:dorsal root ganglia
1405:self-administration
769:histone methylation
527:seminiferous tubule
453:ganglionic eminence
3617:Incentive salience
3605:Inhibitory control
3580:Category:Addiction
3570:Addiction medicine
3365:Relapse prevention
3302:Tanning dependence
2822:(20): 9998–10009.
2748:10.1101/gr.4039406
2482:10.1101/gr.1736803
2394:10.1101/gad.989402
2015:Scientific Reports
1413:dendritic branches
950:ENSMUSG00000013787
727:Biological process
696:Cellular component
625:Molecular function
465:right frontal lobe
3711:
3710:
3650:
3649:
3600:Cognitive control
3558:
3557:
3442:Smoking cessation
3397:Physical exercise
3312:
3311:
3298:Non-drug stimuli
3197:
3196:
3041:Internet-related
2134:(6293): 1576–80.
2035:10.1038/srep37704
1972:(12): 1746–1755.
1812:Neuropharmacology
1581:10.1042/bj2900811
1461:colorectal cancer
1389:nucleus accumbens
1343:residue 9 (i.e.,
1317:), also known as
1308:
1307:
1300:
1253:
1252:
1249:
1248:
1222:
1221:
1187:
1186:
1142:
1141:
1100:
1099:
1067:
1066:
1001:
1000:
982:
981:
956:
955:
937:
936:
885:
884:
866:
865:
814:
813:
667:metal ion binding
609:
608:
605:
604:
567:
566:
554:
553:
531:perirhinal cortex
519:entorhinal cortex
492:
491:
449:nucleus accumbens
390:
389:
289:
288:
184:EHMT2 - orthologs
116:
115:
112:
111:
52:Ortholog search:
3731:
3697:
3677:
3670:
3663:
3654:
3640:
3639:
3327:
3208:
3133:G9a-like protein
2949:
2921:
2914:
2907:
2898:
2892:
2882:
2865:(22): 3089–103.
2849:
2839:
2806:
2769:
2759:
2725:
2715:
2698:(23): 10338–51.
2682:
2649:(7062): 1173–8.
2636:
2626:
2616:
2591:
2581:
2571:
2554:(31): 11257–62.
2538:
2528:
2503:
2493:
2460:
2415:
2405:
2372:
2339:(5570): 1132–6.
2327:
2296:Mammalian Genome
2290:
2280:
2270:
2227:
2226:
2216:
2176:
2170:
2169:
2159:
2119:
2113:
2112:
2079:(7062): 1173–8.
2063:
2057:
2056:
2046:
2006:
2000:
1999:
1989:
1957:
1948:
1943:
1933:
1901:
1895:
1894:
1876:
1852:
1846:
1845:
1835:
1818:(Pt B): 259–68.
1803:
1790:
1789:
1787:
1785:
1770:
1764:
1763:
1761:
1759:
1744:
1735:
1734:
1728:
1724:
1722:
1714:
1704:
1670:
1661:
1660:
1653:
1644:
1643:
1633:
1624:(27): 25309–17.
1609:
1603:
1602:
1592:
1560:
1554:
1553:
1542:
1536:
1535:
1524:
1518:
1508:
1497:
1486:
1373:G9a-like protein
1303:
1296:
1292:
1289:
1283:
1263:
1262:
1255:
1235:
1234:
1206:
1199:
1182:
1146:
1137:
1109:
1105:RefSeq (protein)
1095:
1071:
1062:
1010:
986:
967:
941:
920:
896:
870:
851:
820:
652:zinc ion binding
615:
601:
592:
585:
578:
563:
523:ventricular zone
503:
501:Top expressed in
496:
461:ventricular zone
441:
439:Top expressed in
434:
413:
396:
386:
373:
362:
347:
340:
334:
323:
311:
295:
285:
272:
261:
246:
239:
233:
222:
208:
192:
186:
137:
130:
107:
66:
60:
39:
38:
33:
21:
3739:
3738:
3734:
3733:
3732:
3730:
3729:
3728:
3714:
3713:
3712:
3707:
3704:
3698:
3684:
3681:
3651:
3646:
3628:
3624:Sober companion
3554:
3508:Reagent testing
3484:
3463:
3407:
3401:
3352:
3346:
3321:
3319:
3308:
3237:
3193:
3080:Transcriptional
3072:
3066:
2993:
2979:Methylphenidate
2974:Methamphetamine
2938:
2925:
2895:
2852:
2809:
2787:10.1038/nbt1240
2781:(10): 1285–92.
2772:
2736:Genome Research
2728:
2685:
2639:
2594:
2541:
2506:
2476:(12): 2621–36.
2470:Genome Research
2463:
2427:(6933): 735–8.
2418:
2388:(14): 1779–91.
2375:
2330:
2293:
2240:
2236:
2234:Further reading
2231:
2230:
2178:
2177:
2173:
2121:
2120:
2116:
2065:
2064:
2060:
2008:
2007:
2003:
1978:10.1038/nn.4165
1959:
1958:
1951:
1944:
1922:10.1038/nrn3111
1903:
1902:
1898:
1874:10.1038/nrn3869
1854:
1853:
1849:
1805:
1804:
1793:
1783:
1781:
1780:on 12 June 2018
1772:
1771:
1767:
1757:
1755:
1754:on 12 June 2018
1746:
1745:
1738:
1725:
1715:
1693:
1672:
1671:
1664:
1655:
1654:
1647:
1611:
1610:
1606:
1575:(Pt 3): 811–8.
1562:
1561:
1557:
1544:
1543:
1539:
1526:
1525:
1521:
1509:
1500:
1490:ENSG00000236759
1487:
1478:
1473:
1445:
1443:EHMT2 in cancer
1429:
1399:expression via
1365:
1304:
1293:
1287:
1284:
1276:help improve it
1273:
1264:
1260:
1244:View/Edit Mouse
1239:View/Edit Human
1202:
1195:
1192:Location (UCSC)
1178:
1174:
1168:
1164:
1160:
1156:
1152:
1133:
1129:
1125:
1121:
1117:
1091:
1087:
1083:
1079:
1058:
1054:
1050:
1046:
1042:
1038:
1032:
1028:
1024:
1020:
1016:
931:ENSG00000236759
929:
927:ENSG00000232045
919:
917:ENSG00000227333
915:
913:ENSG00000204371
911:
909:ENSG00000206376
907:
905:ENSG00000224143
903:
901:ENSG00000238134
899:
798:
749:DNA methylation
722:
691:
682:protein binding
597:
587:
586:
559:
550:
545:
541:
537:
533:
529:
525:
521:
517:
513:
499:
488:
483:
479:
475:
473:caudate nucleus
471:
467:
463:
459:
455:
451:
437:
381:
368:
360:
350:
349:
348:
341:
321:
298:Gene location (
280:
267:
259:
249:
248:
247:
240:
218:
195:Gene location (
146:
133:
126:
75:
53:
17:
12:
11:
5:
3737:
3735:
3727:
3726:
3716:
3715:
3709:
3708:
3706:
3705:
3699:
3692:
3689:
3686:
3685:
3682:
3680:
3679:
3672:
3665:
3657:
3648:
3647:
3645:
3644:
3633:
3630:
3629:
3627:
3626:
3621:
3620:
3619:
3609:
3608:
3607:
3597:
3592:
3587:
3582:
3577:
3572:
3566:
3564:
3560:
3559:
3556:
3555:
3553:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3511:
3510:
3500:
3494:
3492:
3490:Harm reduction
3486:
3485:
3483:
3482:
3477:
3471:
3469:
3468:Support groups
3465:
3464:
3462:
3461:
3456:
3455:
3454:
3449:
3439:
3434:
3429:
3424:
3423:
3422:
3411:
3409:
3403:
3402:
3400:
3399:
3394:
3389:
3384:
3379:
3374:
3373:
3372:
3367:
3356:
3354:
3348:
3347:
3345:
3344:
3339:
3333:
3331:
3330:Detoxification
3324:
3314:
3313:
3310:
3309:
3307:
3306:
3305:
3304:
3296:
3295:
3294:
3289:
3284:
3279:
3274:
3269:
3267:Benzodiazepine
3264:
3259:
3254:
3245:
3243:
3239:
3238:
3236:
3235:
3230:
3225:
3220:
3214:
3212:
3205:
3199:
3198:
3195:
3194:
3192:
3191:
3190:
3189:
3186:
3181:
3176:
3171:
3166:
3161:
3156:
3149:
3142:
3135:
3130:
3117:
3116:
3115:
3114:
3109:
3104:
3099:
3094:
3089:
3076:
3074:
3068:
3067:
3065:
3064:
3059:
3054:
3053:
3052:
3047:
3039:
3038:
3037:
3032:
3024:
3022:Palatable food
3019:
3018:
3017:
3012:
3003:
3001:
2995:
2994:
2992:
2991:
2986:
2981:
2976:
2971:
2966:
2961:
2955:
2953:
2946:
2940:
2939:
2926:
2924:
2923:
2916:
2909:
2901:
2894:
2893:
2850:
2807:
2770:
2726:
2683:
2637:
2607:(7): 5563–70.
2592:
2539:
2513:Molecular Cell
2504:
2461:
2416:
2373:
2328:
2302:(12): 916–24.
2291:
2253:(22): 8955–8.
2237:
2235:
2232:
2229:
2228:
2171:
2114:
2058:
2001:
1949:
1916:(11): 623–37.
1896:
1847:
1791:
1765:
1736:
1727:|journal=
1691:
1662:
1645:
1604:
1555:
1537:
1519:
1498:
1475:
1474:
1472:
1469:
1449:tumorigenicity
1444:
1441:
1428:
1425:
1364:
1361:
1357:gene silencing
1306:
1305:
1267:
1265:
1258:
1251:
1250:
1247:
1246:
1241:
1231:
1230:
1224:
1223:
1220:
1219:
1217:
1215:
1208:
1207:
1200:
1193:
1189:
1188:
1185:
1184:
1170:
1169:
1143:
1140:
1139:
1113:
1112:
1106:
1102:
1101:
1098:
1097:
1075:
1074:
1068:
1065:
1064:
1034:
1033:
1007:
1003:
1002:
999:
998:
990:
989:
983:
980:
979:
971:
970:
964:
958:
957:
954:
953:
945:
944:
938:
935:
934:
922:
921:
893:
887:
886:
883:
882:
874:
873:
867:
864:
863:
855:
854:
848:
842:
841:
836:
831:
827:
826:
816:
815:
812:
811:
800:
799:
797:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
730:
728:
724:
723:
721:
720:
715:
710:
705:
699:
697:
693:
692:
690:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
628:
626:
622:
621:
611:
610:
607:
606:
603:
602:
594:
593:
575:
569:
568:
565:
564:
556:
555:
552:
551:
549:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
505:
504:
493:
490:
489:
487:
486:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
443:
442:
430:
429:
421:
410:
404:
403:
400:RNA expression
392:
391:
388:
387:
379:
375:
374:
366:
363:
358:
352:
351:
342:
335:
329:
325:
324:
319:
313:
312:
304:
303:
291:
290:
287:
286:
278:
274:
273:
265:
262:
257:
251:
250:
241:
234:
228:
224:
223:
216:
210:
209:
201:
200:
188:
187:
144:
140:
139:
131:
123:
122:
118:
117:
114:
113:
110:
109:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
3736:
3725:
3722:
3721:
3719:
3702:
3696:
3691:
3687:
3678:
3673:
3671:
3666:
3664:
3659:
3658:
3655:
3643:
3635:
3634:
3631:
3625:
3622:
3618:
3615:
3614:
3613:
3610:
3606:
3603:
3602:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3567:
3565:
3561:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3509:
3506:
3505:
3504:
3503:Drug checking
3501:
3499:
3496:
3495:
3493:
3491:
3487:
3481:
3478:
3476:
3473:
3472:
3470:
3466:
3460:
3457:
3453:
3450:
3448:
3445:
3444:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3421:
3418:
3417:
3416:
3413:
3412:
3410:
3404:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3371:
3368:
3366:
3363:
3362:
3361:
3358:
3357:
3355:
3349:
3343:
3340:
3338:
3335:
3334:
3332:
3328:
3325:
3323:
3315:
3303:
3300:
3299:
3297:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3249:
3247:
3246:
3244:
3240:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3215:
3213:
3209:
3206:
3204:
3200:
3187:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3154:
3150:
3148:
3147:
3143:
3141:
3140:
3136:
3134:
3131:
3129:
3128:
3124:
3123:
3122:
3119:
3118:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3087:
3083:
3082:
3081:
3078:
3077:
3075:
3069:
3063:
3060:
3058:
3055:
3051:
3048:
3046:
3043:
3042:
3040:
3036:
3033:
3031:
3028:
3027:
3025:
3023:
3020:
3016:
3013:
3011:
3008:
3007:
3005:
3004:
3002:
3000:
2996:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2956:
2954:
2950:
2947:
2945:
2941:
2937:
2933:
2929:
2928:Reinforcement
2922:
2917:
2915:
2910:
2908:
2903:
2902:
2899:
2890:
2886:
2881:
2876:
2872:
2868:
2864:
2860:
2856:
2851:
2847:
2843:
2838:
2833:
2829:
2825:
2821:
2817:
2813:
2808:
2804:
2800:
2796:
2792:
2788:
2784:
2780:
2776:
2771:
2767:
2763:
2758:
2753:
2749:
2745:
2741:
2737:
2733:
2727:
2723:
2719:
2714:
2709:
2705:
2701:
2697:
2693:
2689:
2684:
2680:
2676:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2638:
2634:
2630:
2625:
2620:
2615:
2610:
2606:
2602:
2598:
2593:
2589:
2585:
2580:
2575:
2570:
2565:
2561:
2557:
2553:
2549:
2545:
2540:
2536:
2532:
2527:
2522:
2519:(6): 727–38.
2518:
2514:
2510:
2505:
2501:
2497:
2492:
2487:
2483:
2479:
2475:
2471:
2467:
2462:
2458:
2454:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2417:
2413:
2409:
2404:
2399:
2395:
2391:
2387:
2383:
2379:
2374:
2370:
2366:
2362:
2358:
2354:
2350:
2346:
2342:
2338:
2334:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2301:
2297:
2292:
2288:
2284:
2279:
2274:
2269:
2264:
2260:
2256:
2252:
2248:
2244:
2239:
2238:
2233:
2224:
2220:
2215:
2210:
2206:
2202:
2198:
2194:
2190:
2186:
2182:
2175:
2172:
2167:
2163:
2158:
2153:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2118:
2115:
2110:
2106:
2102:
2098:
2094:
2090:
2086:
2082:
2078:
2074:
2070:
2062:
2059:
2054:
2050:
2045:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2005:
2002:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1954:
1950:
1947:
1941:
1937:
1932:
1927:
1923:
1919:
1915:
1911:
1907:
1900:
1897:
1892:
1888:
1884:
1880:
1875:
1870:
1867:(12): 768–9.
1866:
1862:
1858:
1851:
1848:
1843:
1839:
1834:
1829:
1825:
1821:
1817:
1813:
1809:
1802:
1800:
1798:
1796:
1792:
1779:
1775:
1769:
1766:
1753:
1749:
1743:
1741:
1737:
1732:
1720:
1712:
1708:
1703:
1698:
1694:
1692:9780128015834
1688:
1684:
1680:
1676:
1669:
1667:
1663:
1658:
1652:
1650:
1646:
1641:
1637:
1632:
1627:
1623:
1619:
1615:
1608:
1605:
1600:
1596:
1591:
1586:
1582:
1578:
1574:
1570:
1566:
1559:
1556:
1551:
1547:
1541:
1538:
1533:
1529:
1523:
1520:
1516:
1512:
1507:
1505:
1503:
1499:
1495:
1491:
1485:
1483:
1481:
1477:
1470:
1468:
1466:
1462:
1458:
1454:
1450:
1442:
1440:
1438:
1434:
1426:
1424:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1379:, which is a
1378:
1374:
1369:
1362:
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3084:
3026:Sex-related
2862:
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2778:
2774:
2742:(1): 55–65.
2739:
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2018:
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1969:
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1782:. Retrieved
1778:the original
1768:
1756:. Retrieved
1752:the original
1674:
1621:
1617:
1607:
1572:
1568:
1558:
1549:
1540:
1531:
1522:
1457:solid tumors
1446:
1430:
1427:Interactions
1370:
1366:
1329:
1318:
1314:
1310:
1309:
1294:
1285:
1269:
1180:NP_001390799
1176:NP_001390798
1173:
1166:NP_001390796
1154:NP_001273504
1150:NP_001273502
1135:NP_001350618
1123:NP_001305762
1119:NP_001276342
1116:
1085:NM_001286575
1081:NM_001286573
1078:
1060:NM_001395165
1056:NM_001395164
1052:NM_001395163
1048:NM_001395162
1044:NM_001395161
1040:NM_001395160
1037:
1030:NM_001363689
1026:NM_001318833
1014:NM_001289413
993:
974:
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858:
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535:spermatocyte
423:
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143:External IDs
74:
18:
3683:PDB gallery
3351:Behavioral
3262:Barbiturate
3257:Amphetamine
3035:Pornography
3030:Intercourse
2964:Amphetamine
2930:disorders:
2185:Oncogenesis
1465:lung cancer
1387:within the
754:methylation
703:nucleoplasm
687:p53 binding
382:35,133,028
369:35,117,445
281:31,897,687
268:31,879,759
121:Identifiers
3575:Allen Carr
3415:Drug rehab
3406:Treatment
3322:management
3318:Treatment
3252:Alcoholism
3233:Withdrawal
3203:Dependence
3121:Epigenetic
3073:mechanisms
3006:Financial
2999:Behavioral
2936:dependence
2191:(11): 76.
1517:, May 2017
1496:, May 2017
1471:References
1381:repressive
1337:histone H3
708:chromosome
427:(ortholog)
164:HomoloGene
3353:therapies
3242:Disorders
2944:Addiction
2932:addiction
2205:2157-9024
2069:Zoghbi HY
2021:: 37704.
1729:ignored (
1719:cite book
1455:, and in
1393:addiction
1288:July 2018
1162:NP_671493
1158:NP_665829
1131:NP_079532
1127:NP_006700
1093:NM_147151
1089:NM_145830
1022:NM_025256
1018:NM_006709
824:Orthologs
515:spermatid
172:GeneCards
3718:Category
3642:Category
3563:See also
3408:programs
3287:Nicotine
3277:Cannabis
3272:Caffeine
3211:Concepts
3071:Cellular
3015:Shopping
3010:Gambling
2984:Nicotine
2889:17085482
2846:17005678
2803:14294292
2795:16964243
2766:16344560
2722:16287849
2671:16189514
2633:15590646
2588:15269344
2535:15200951
2500:14656967
2449:12700765
2412:12130538
2369:34863978
2361:12004135
2316:11707778
2223:34775469
2166:27339988
2101:16189514
2053:27874088
1996:26551542
1940:21989194
1891:11513288
1883:25409693
1842:23643695
1711:26472529
1640:11316813
1513:–
1492:–
1453:leukemia
1437:KIAA0515
1433:interact
1371:G9a and
1363:Function
1353:H3K27me1
1228:Wikidata
803:Sources:
481:amygdala
3282:Cocaine
2969:Cocaine
2959:Alcohol
2880:1635145
2837:1617317
2757:1356129
2713:1291230
2679:4427026
2651:Bibcode
2624:2696276
2556:Bibcode
2457:2670859
2429:Bibcode
2341:Bibcode
2333:Science
2324:9510386
2287:2813433
2255:Bibcode
2214:8590690
2157:5507586
2136:Bibcode
2128:Science
2109:4427026
2081:Bibcode
2044:5118693
2023:Bibcode
1987:4661086
1931:3272277
1833:3766384
1702:4690450
1599:8457211
1590:1132354
1515:Ensembl
1494:Ensembl
1401:H3K9me2
1377:H3K9me2
1349:H3K9me2
1345:H3K9me1
1321:, is a
1274:Please
962:UniProt
891:Ensembl
830:Species
809:QuickGO
713:nucleus
457:putamen
402:pattern
260:6p21.33
160:2148922
128:Aliases
3292:Opioid
3248:Drugs
3174:HDAC10
2989:Opioid
2887:
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1758:8 June
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1417:spines
1341:lysine
1326:enzyme
1214:search
1212:PubMed
995:Q9Z148
976:Q96KQ7
879:110147
846:Entrez
573:BioGPS
152:604599
3184:SIRT2
3179:SIRT1
3169:HDAC9
3164:HDAC5
3159:HDAC4
3153:HDAC3
3146:HDAC2
3139:HDAC1
3112:NF-κB
3107:GluR2
3092:c-Fos
3086:ΔFosB
2799:S2CID
2675:S2CID
2453:S2CID
2365:S2CID
2320:S2CID
2105:S2CID
1887:S2CID
1459:, as
1435:with
1397:ΔFosB
1330:EHMT2
1315:EHMT2
860:10919
839:Mouse
834:Human
805:Amigo
425:Mouse
418:Human
365:Start
300:Mouse
264:Start
197:Human
176:EHMT2
168:48460
135:EHMT2
24:EHMT2
3701:2o8j
3320:and
3102:CREB
3097:Cdk5
2952:Drug
2934:and
2885:PMID
2842:PMID
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2718:PMID
2667:PMID
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2408:PMID
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2201:ISSN
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1992:PMID
1936:PMID
1879:PMID
1838:PMID
1786:2018
1760:2018
1731:help
1707:PMID
1687:ISBN
1636:PMID
1595:PMID
1415:and
1347:and
1333:gene
408:Bgee
356:Band
317:Chr.
255:Band
214:Chr.
148:OMIM
105:5JIN
101:5JHN
97:5JJ0
93:4NVQ
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81:3DM1
77:2O8J
58:RCSB
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3188:...
3127:G9a
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